CN105854068A - Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof - Google Patents
Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof Download PDFInfo
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- CN105854068A CN105854068A CN201510029654.1A CN201510029654A CN105854068A CN 105854068 A CN105854068 A CN 105854068A CN 201510029654 A CN201510029654 A CN 201510029654A CN 105854068 A CN105854068 A CN 105854068A
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- sodium alginate
- chinese medicine
- berberine
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- electrostatic spinning
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 63
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 63
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 63
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 229940093265 berberine Drugs 0.000 title claims abstract description 29
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000002121 nanofiber Substances 0.000 title claims abstract description 22
- 230000003115 biocidal effect Effects 0.000 title abstract description 8
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 30
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 29
- 206010059866 Drug resistance Diseases 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 34
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 34
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 34
- 229940068984 polyvinyl alcohol Drugs 0.000 claims description 34
- 239000004615 ingredient Substances 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000009987 spinning Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 238000007872 degassing Methods 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000004113 cell culture Methods 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 23
- 239000000203 mixture Substances 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 239000012567 medical material Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- AEMOLEFTQBMNLQ-AZLKCVHYSA-N (2r,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-AZLKCVHYSA-N 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- -1 ammonia polysaccharide Chemical class 0.000 description 1
- 229920001448 anionic polyelectrolyte Polymers 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Artificial Filaments (AREA)
Abstract
The invention discloses a sodium alginate nanofiber surgical dressing containing a traditional Chinese medicine antibiotic component berberine. The sodium alginate nanofiber surgical dressing is prepared by sodium alginate, polyving akohol and the traditional Chinese medicine antibiotic component berberine by an electrostatic spinning method; wherein the proportion of a sodium alginate solution to a polyving akohol solution in an electrostatic spinning solution is 4:6-5:5, and content of berberine accounts for 3-6wt% of that of sodium alginate and polyving akohol. Due to no addition of harmful substances such as a strong non-polar solution during a preparation method of the surgical dressing, the used berberine is safe and harmless, bacteria cannot generate drug resistance, the sodium alginate nanofiber surgical dressing containing the traditional Chinese medicine antibiotic component berberine has the advantages of safe and reliable usage and high efficiency bacterinertness, and has escherichia coli antibacterial rate being 92.9-97.1%.
Description
Technical field
The invention belongs to polymeric material field, particularly relate to a kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial composition and preparation method thereof.
Background technology
Sodium alginate is a kind of natural polysaccharide mostling come from algae, is mainly made up of Isosorbide-5-Nitrae-beta-D-mannuronic acid (M unit) and α-L-guluronic acid (G unit), similar to the protein-polysaccharide composition in human body cell epimatrix；Sodium alginate also has that source is wide, good biocompatibility, have the good characteristics such as controlled biological degradability and nonhazardous and will not cause antigen-reactive；These characteristics make it have huge application potential in medical dressing field.
The main component proteoglycan (Fructus Vitis viniferae ammonia polysaccharide (GAG)) of the natural extracellular matrix in tissue and fibrin all have nanostructured composition；Research shows that nanostructured medical material contributes to cell adhesion and propagation, and function is higher than micro-meter scale, and therefore, nanofiber has higher value in medical dressing field；The main method preparing nanofiber at present is electrostatic spinning；But owing to sodium alginate is a kind of anionic polyelectrolyte, its strand is in aqueous in rigidity and there is vermiform to extend, and pure sodium alginate Static Spinning is extremely difficult.
Wound infection is the key factor affecting wound healing, is also the major reason causing patient wound the most dead；Accordingly, as good medical dressing, should have preferable anti-microbial property；Conventional medical dressing, in order to obtain anti-microbial property, is usually and adds a certain amount of antibiotic in medical dressing, or have the metal ion such as nanometer silver etc. of anti-microbial property；But, if using antibiotic pathogenic bacteria can be made to morph and produce drug resistance for a long time, metallic, also due to major part is all heavy metal, has potential hazard to human organ during use.
Summary of the invention
The invention aims to solve above-mentioned technical problem and provide a kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine；This material is prepared from by electrostatic spinning means by sodium alginate, polyvinyl alcohol and Chinese medicine antibacterial ingredient berberine.In its blend spinning liquid, the ratio of sodium alginate soln and poly-vinyl alcohol solution is 4:6-5:5, the content of Chinese medicine antibacterial ingredient berberine is sodium alginate and the 3wt%-6wt% of polyvinyl alcohol quality, final prepare containing Chinese medicine antibacterial composition sodium alginate nano fiber medical dressing colibacillary bacteriostasis rate is reached 92.9%-97.1%.
The present invention takes techniques below scheme for achieving the above object: prepares the sodium alginate soln of certain mass mark and poly-vinyl alcohol solution and is mixed and added into the NaCl of surfactant TX-100 and 0.5wt% of 0.5wt%-2wt% with the ratio of 4:6-5:5 and mixs homogeneously with agitator stirring 2h, then adds the Chinese medicine antibacterial ingredient berberine of the 3wt%-6wt% of sodium alginate, polyvinyl alcohol quality and stirs 6h and be prepared as spinning liquid；Inject in needle tubing after the spinning liquid of mix homogeneously is stood froth breaking 24h, utilize electrostatic spinning apparatus carry out electrostatic spinning and prepare the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial composition.
The concrete preparation method of the present invention is:
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 4:6-5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 0.5wt%-2wt% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 3wt%-6wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 12-25kV, and the distance of shower nozzle to receptor is 5-20cm, and flow is 0.1-1.5ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine can be collected on the receiver.
Advantages of the present invention is: polyvinyl alcohol is a kind of water-soluble macromolecule polymer nontoxic, degradable, has preferable chain entanglement degree at aqueous solution, can be prepared by electrostatic spinning, is a kind of conventional medical material；TX-100 is a kind of nontoxic nonionic type surfactant by U.S. FDA certification, by by sodium alginate and polyvinyl alcohol, under the effect of TX-100 and NaCl, the electrostatic spinning of sodium alginate is achieved under conditions of with deionized water as solvent, and improve the ratio of sodium alginate soln to 50%, the feature that the sodium alginate nano fiber dressing of preparation has environmental protection, nontoxic and sodium alginate content is high；Chinese medicine antibacterial ingredient berberine is the plant essence extracted from natural Chinese medicinal herb, not only there is preferable antibiotic property, and compared with antibiotic and metal ion antibacterial agent, both antibacterial will not have been made to produce drug resistance, also human body will not be caused potential hazard, the sodium alginate nano fiber medical dressing that berberine is mixed in sodium alginate/poly-vinyl alcohol solution preparation is not respectively provided with high-efficiency antimicrobial, and safety.
Detailed description of the invention
Embodiment
1
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 4:6, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 0.5wt%% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 3wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 16kV, and the distance of shower nozzle to receptor is 18cm, and flow is 0.8ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing 3wt% Chinese medicine antibacterial ingredient berberine can be collected on the receiver；It is 92.9% to colibacillary bacteriostasis rate.
Embodiment
2
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 1.5wt%% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 4wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 18kV, and the distance of shower nozzle to receptor is 20cm, and flow is 0.8ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing 4wt% Chinese medicine antibacterial ingredient berberine can be collected on the receiver；It is 94.3% to colibacillary bacteriostasis rate.
Embodiment
3
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%.
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C.
(3) preparation of electrostatic spinning liquid: with the ratio of 5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction TX-100 and 0.5wt% as 1.5wt%% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 5wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution.
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus, regulation voltage is 20kV, and the distance of shower nozzle to receptor is 20cm, and flow is 0.8ml/h；Open device for spinning, the sodium alginate nano fiber medical dressing containing 4wt% Chinese medicine antibacterial ingredient berberine can be collected on the receiver；It is 97.1% to colibacillary bacteriostasis rate.
Claims (4)
1. the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine, it is characterised in that this material is prepared from by electrostatic spinning means by sodium alginate, polyvinyl alcohol and Chinese medicine antibacterial ingredient berberine.
A kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine the most according to claim 1, it is characterised in that electrostatic spinning is prepared detailed process and is:
(1) preparation of sodium alginate soln: sodium alginate is dissolved in deionized water and stirs 2h at normal temperatures and prepare the sodium alginate soln that mass fraction is 3wt%；
(2) preparation of poly-vinyl alcohol solution: it is the poly-vinyl alcohol solution of 10wt% that a certain amount of polyvinyl alcohol is dissolved in deionized water stirring 4h acquisition mass fraction under conditions of 90 DEG C；
(3) preparation of electrostatic spinning liquid: with the ratio of 4:6-5:5, the poly-vinyl alcohol solution of the sodium alginate soln of 3wt% and 10wt% being mixed NaCl stirring 2h that is mixed and that add the mass fraction surfactant as 0.5wt%-2wt% and 0.5wt% and mixs homogeneously, the Chinese medicine antibacterial ingredient berberine stirring 6h the discontinuous degassing that then add the 3wt%-6wt% of sodium alginate, polyvinyl alcohol quality obtain electrostatic spinning solution；
(4) preparation of nano fibrous membrane: injected by electrostatic spinning solution in the needle tubing of electrostatic spinning apparatus (as shown in Figure 1), regulation voltage is 12-25kV, and the distance of shower nozzle to receptor is 5-20cm, and flow is 0.1-1.5ml/h；
Open device for spinning, the sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine can be collected on the receiver.
A kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine the most according to claim 2, it is characterized in that, surfactant used is TX-100, it it is a kind of nonionic surfactant by U.S. FDA certification, there is nontoxic feature, be widely used in the fields such as cell cultivation.
A kind of sodium alginate nano fiber medical dressing containing Chinese medicine antibacterial ingredient berberine the most according to claim 2, it is characterized in that, Chinese medicine antibacterial ingredient berberine used is a kind of plant essence extracted from Chinese herbal medicine, there is nontoxic feature, and antibacterial will not be made to produce drug resistance, it is a kind of efficiently antibacterial of safety.
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| CN201510029654.1A CN105854068A (en) | 2015-01-21 | 2015-01-21 | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof |
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| CN201510029654.1A CN105854068A (en) | 2015-01-21 | 2015-01-21 | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof |
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| CN201510029654.1A Pending CN105854068A (en) | 2015-01-21 | 2015-01-21 | Sodium alginate nanofiber surgical dressing containing traditional Chinese medicine antibiotic component berberine and preparation method thereof |
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Cited By (11)
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| CN106581730A (en) * | 2016-11-24 | 2017-04-26 | 阜阳市汇康医疗器械有限公司 | Antimicrobial deodorant medical cotton swab containing neem oil |
| CN108283727A (en) * | 2018-03-26 | 2018-07-17 | 广东工业大学 | A kind of nanofiber dressing and preparation method thereof |
| CN108686253A (en) * | 2018-06-21 | 2018-10-23 | 东莞市联洲知识产权运营管理有限公司 | A kind of preparation method of high-efficiency antimicrobial medical dressing |
| CN108939136A (en) * | 2018-08-20 | 2018-12-07 | 重庆医科大学附属永川医院 | A kind of dressing and preparation method thereof for nose filling hemostasis |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| CN110241514A (en) * | 2019-04-25 | 2019-09-17 | 扬州纪元纺织有限公司 | A kind of chitosan filament non-woven fabrics and plant-source antibacterial nanofiber composite material and preparation method thereof |
| CN114306710A (en) * | 2021-12-30 | 2022-04-12 | 佛山市中医院 | Medical dressing and preparation method thereof |
| CN115212338A (en) * | 2022-07-12 | 2022-10-21 | 成都大学 | Polycaprolactone-xanthan gum-berberine composite biological membrane and preparation method and application thereof |
| CN117258030A (en) * | 2023-11-20 | 2023-12-22 | 苏州恒星医用材料有限公司 | Calotropis gigantea fiber-based hydrogel dressing, and preparation method and application thereof |
| CN118806981A (en) * | 2024-09-18 | 2024-10-22 | 山东理工大学 | Preparation method and application of traditional Chinese medicine quantum dot antibacterial hydrogel dressing |
| CN118806982A (en) * | 2024-09-18 | 2024-10-22 | 山东理工大学 | A pH-responsive antibacterial hydrogel dressing, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106581730A (en) * | 2016-11-24 | 2017-04-26 | 阜阳市汇康医疗器械有限公司 | Antimicrobial deodorant medical cotton swab containing neem oil |
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| CN108939136B (en) * | 2018-08-20 | 2020-12-22 | 重庆医科大学附属永川医院 | A kind of dressing for nose filling and hemostasis and preparation method thereof |
| CN108939136A (en) * | 2018-08-20 | 2018-12-07 | 重庆医科大学附属永川医院 | A kind of dressing and preparation method thereof for nose filling hemostasis |
| CN110124094A (en) * | 2019-04-19 | 2019-08-16 | 青岛大学 | A kind of Chinese herbal medicine based micro-nano fibre antibacterial dressing be prepared in situ and application method |
| CN110241514A (en) * | 2019-04-25 | 2019-09-17 | 扬州纪元纺织有限公司 | A kind of chitosan filament non-woven fabrics and plant-source antibacterial nanofiber composite material and preparation method thereof |
| CN114306710A (en) * | 2021-12-30 | 2022-04-12 | 佛山市中医院 | Medical dressing and preparation method thereof |
| CN115212338A (en) * | 2022-07-12 | 2022-10-21 | 成都大学 | Polycaprolactone-xanthan gum-berberine composite biological membrane and preparation method and application thereof |
| CN117258030A (en) * | 2023-11-20 | 2023-12-22 | 苏州恒星医用材料有限公司 | Calotropis gigantea fiber-based hydrogel dressing, and preparation method and application thereof |
| CN117258030B (en) * | 2023-11-20 | 2024-02-13 | 苏州恒星医用材料有限公司 | Calotropis gigantea fiber-based hydrogel dressing, and preparation method and application thereof |
| CN118806981A (en) * | 2024-09-18 | 2024-10-22 | 山东理工大学 | Preparation method and application of traditional Chinese medicine quantum dot antibacterial hydrogel dressing |
| CN118806982A (en) * | 2024-09-18 | 2024-10-22 | 山东理工大学 | A pH-responsive antibacterial hydrogel dressing, preparation method and application thereof |
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Application publication date: 20160817 |