CN105796675A - 一种清热颗粒及其制备方法 - Google Patents
一种清热颗粒及其制备方法 Download PDFInfo
- Publication number
- CN105796675A CN105796675A CN201610212263.8A CN201610212263A CN105796675A CN 105796675 A CN105796675 A CN 105796675A CN 201610212263 A CN201610212263 A CN 201610212263A CN 105796675 A CN105796675 A CN 105796675A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- heat
- granule
- clearing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明提供一种清热颗粒及其制备方法，清热颗粒的主要原料按重量份计包括：黄连25‑28份、大黄15‑20份、黄芩15‑18份、防风10‑12份、荆芥8‑10份、紫苏叶7‑10份、连翘7‑9份、大青叶6‑9份、桔梗5‑8份、附子2‑5份。本发明的生产工艺简单，有效成分的提取率高，清热降火效果显著，市场前景极大。
Description
技术领域
本发明属于医药技术领域，具体涉及一种清热颗粒及其制备方法。
背景技术
黄连，性寒，清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。酒黄连善清上焦火热。用于目赤，口疮。姜黄连清胃和胃止呕。用于寒热互结，湿热中阻，痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和，呕吐吞酸。
大黄，性寒，具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒等功效。
黄芩，味苦、性寒，有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。黄芩的临床抗菌性比黄连好，而且不产生抗药性。
附子，又名乌头或附片，中药中“回阳救逆第一品”。功能主治：回阳救逆、 补火助阳，散寒止痛。治阴盛格阳，大汗亡阳，吐利厥逆，心腹冷痛，脾泄冷痢，脚气水肿小儿慢惊，风寒湿痹，踒躄拘挛，阳萎宫冷，阴疽疮漏及一切沉寒痼冷之疾。《神农本草经》记载：主治风寒咳逆邪气，温中，除寒湿，治手足折伤，拘挛、膝痛不能行走，破肿块坚硬、血瘕、金属损伤疮伤。附子味辛，性大热，有毒，温里散寒、助阳行水、补火、止痛和局麻等功效。
清热药的药性寒凉，主要用于热病高热、痢疾、痈肿疮毒、以及目赤肿痛、咽喉肿痛等呈现各种里热证候、即是《内经》所说“热者寒之”的意义。本发明采用性大热的附子辅助黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗进行清热治疗，效果显著；附子与黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗进行协同作用，清热效果较黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗配合使用时，显著得多。
目前市售的清热颗粒均采用传统的制备工艺提取其挥发油，即水蒸汽蒸馏法，这种制备工艺存在很多弊端，其提取率低，不能将某些高沸点，低挥发度的成分全部提取出来，而且长时间处于高温状态下，药物的挥发性成分容易逸散，某些易热解的物质或化学不稳定性成分也易被破坏，药材的有效成分损失巨大，严重影响了药物的疗效。传统的水煎煮提取也是在高温下进行，使药材的部分有效成分因长时间受热而被破坏，而且提取率低，对药物的疗效也有很大的影响。本发明采用高压提取法，在低温下对中药的有效成分进行提取，避免了有效成分因长时间受热而被破坏，本发明的制备工艺简单高效，市场前景极大。
发明内容
本发明的目的在于提供一种清热颗粒及其制备方法，依据本发明的配方生产出来是清热颗粒疗效显著，本发明同时还提供一种低温下制备清热颗粒的方法，避免了有效成分因长时间受热而被破坏，本发明的制备工艺简单高效，市场前景极大。
为实现上述目的，本发明采用如下技术方案：
一种清热颗粒，其主要原料按重量份计包括：黄连25-28份、大黄15-20份、黄芩15-18份、防风10-12份、荆芥8-10份、紫苏叶7-10份、连翘7-9份、大青叶6-9份、桔梗5-8份、附子2-5份。
所述清热颗粒的具体制备方法如下：
（1）将黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗、附子粉碎成30-50目粗粉，加粗粉总重量6-8倍的水，超高压提取1-3次，压力为100-300MPa，每次保压5-10分钟，合并提取液，过滤，减压浓缩至50℃时相对密度为1.30～1.33的清膏；
（2）向步骤(1)得到的清膏中加入蔗糖和糊精适量，制成颗粒，干燥后即得。
所述步骤（1）中水提取的温度为60-80℃。
具体实施方式
为了使本发明所述的内容更加便于理解，下面结合具体实施方式对本发明所述的技术方案做进一步的说明，但是本发明不仅限于此。
实施例
1
一种清热颗粒，其主要原料按重量份计包括：黄连25份、大黄15份、黄芩15份、防风10份、荆芥8份、紫苏叶7份、连翘7份、大青叶6份、桔梗5份、附子2份。
所述清热颗粒的具体制备方法如下：
（1）将黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗、附子粉碎成30目粗粉，加粗粉总重量6倍的水，超高压提取1次，压力为100MPa，每次保压5分钟，合并提取液，过滤，减压浓缩至50℃时相对密度为1.30的清膏；
（2）向步骤(1)得到的清膏中加入蔗糖和糊精适量，制成颗粒，干燥后即得。
所述步骤（1）中水提取的温度为60℃。
实施例
2
一种清热颗粒，其主要原料按重量份计包括：黄连26份、大黄18份、黄芩16份、防风11份、荆芥9份、紫苏叶9份、连翘8份、大青叶7份、桔梗6份、附子3份。
所述清热颗粒的具体制备方法如下：
（1）将黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗、附子粉碎成40目粗粉，加粗粉总重量7倍的水，超高压提取2次，压力为200MPa，每次保压8分钟，合并提取液，过滤，减压浓缩至50℃时相对密度为1.31的清膏；
（2）向步骤(1)得到的清膏中加入蔗糖和糊精适量，制成颗粒，干燥后即得。
所述步骤（1）中水提取的温度为70℃。
实施例
3
一种清热颗粒，其主要原料按重量份计包括：黄连28份、大黄20份、黄芩18份、防风12份、荆芥10份、紫苏叶10份、连翘9份、大青叶9份、桔梗8份、附子5份。
所述清热颗粒的具体制备方法如下：
（1）将黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗、附子粉碎成50目粗粉，加粗粉总重量8倍的水，超高压提取3次，压力为300MPa，每次保压10分钟，合并提取液，过滤，减压浓缩至50℃时相对密度为1.33的清膏；
（2）向步骤(1)得到的清膏中加入蔗糖和糊精适量，制成颗粒，干燥后即得。
所述步骤（1）中水提取的温度为80℃。
以上所述仅为本发明的较佳实施例，凡依本发明申请专利范围所做的均等变化与修饰，皆应属本发明的涵盖范围。
Claims (3)
1.一种清热颗粒，其特征在于，所述清热颗粒的主要原料按重量份计包括：黄连25-28份、大黄15-20份、黄芩15-18份、防风10-12份、荆芥8-10份、紫苏叶7-10份、连翘7-9份、大青叶6-9份、桔梗5-8份、附子2-5份。
2.根据权利要求1所述的清热颗粒，其特征在于，所述清热颗粒的具体制备方法如下：
(1)将黄连、大黄、黄芩、防风、荆芥、紫苏叶、连翘、大青叶、桔梗、附子粉碎成30-50目粗粉，加粗粉总重量6-8倍的水，超高压提取1-3次，压力为100-300MPa，每次保压5-10分钟，合并提取液，过滤，减压浓缩至50℃时相对密度为1.30～1.33的清膏；
(2)向步骤(1)得到的清膏中加入蔗糖和糊精适量，制成颗粒，干燥后即得。
3.根据权利要求2所述的清热颗粒的制备方法，其特征在于，所述步骤（1）中水提取的温度为60-80℃。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610212263.8A CN105796675A (zh) | 2016-04-07 | 2016-04-07 | 一种清热颗粒及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610212263.8A CN105796675A (zh) | 2016-04-07 | 2016-04-07 | 一种清热颗粒及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105796675A true CN105796675A (zh) | 2016-07-27 |
Family
ID=56459657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610212263.8A Pending CN105796675A (zh) | 2016-04-07 | 2016-04-07 | 一种清热颗粒及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105796675A (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939430A (zh) * | 2005-09-30 | 2007-04-04 | 江西本草天工科技有限责任公司 | 一清分散片 |
| CN101264200A (zh) * | 2008-02-27 | 2008-09-17 | 李浪辉 | 一种四季感冒丸及其制备方法 |
| CN102961658A (zh) * | 2012-12-05 | 2013-03-13 | 江苏老蚕坊蚕桑生物科技开发有限公司 | 一种清热解毒膏 |
| CN104800382A (zh) * | 2015-04-16 | 2015-07-29 | 广东联康药业有限公司 | 一种用于治疗感冒的中药组合物及其制备方法和应用 |
-
2016
- 2016-04-07 CN CN201610212263.8A patent/CN105796675A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939430A (zh) * | 2005-09-30 | 2007-04-04 | 江西本草天工科技有限责任公司 | 一清分散片 |
| CN101264200A (zh) * | 2008-02-27 | 2008-09-17 | 李浪辉 | 一种四季感冒丸及其制备方法 |
| CN102961658A (zh) * | 2012-12-05 | 2013-03-13 | 江苏老蚕坊蚕桑生物科技开发有限公司 | 一种清热解毒膏 |
| CN104800382A (zh) * | 2015-04-16 | 2015-07-29 | 广东联康药业有限公司 | 一种用于治疗感冒的中药组合物及其制备方法和应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jiang et al. | Post-infectious cough of different syndromes treated by traditional Chinese medicines: a review | |
| CN103006872B (zh) | 一种治疗感冒的中药制剂 | |
| CN102349962B (zh) | 一种治疗疖肿的外用中药 | |
| CN103784584A (zh) | 治疗脸皮肤炎的中草药 | |
| CN103110705A (zh) | 一种治疗小儿风寒感冒的中药组合物及其制备方法 | |
| CN101011556A (zh) | 一种治疗闭经的中药制备方法 | |
| CN103860955A (zh) | 一种治疗人乳头瘤病毒感染中药组合物及其制备方法 | |
| CN105796675A (zh) | 一种清热颗粒及其制备方法 | |
| CN103386064A (zh) | 一种中药贴剂 | |
| CN105616641A (zh) | 一种治疗梅毒感染的中药制剂及其制备方法 | |
| CN104083521A (zh) | 治疗吐血的中药制剂 | |
| CN104435951A (zh) | 一种抗缺氧中药 | |
| CN105106527B (zh) | 一种中药组合物及其制备方法与制药应用 | |
| CN103520594B (zh) | 治疗湿热内蕴证型粉刺病的中药 | |
| CN102327440A (zh) | 治疗流注的中草药 | |
| CN102327381A (zh) | 治疗痄腮的中草药 | |
| CN110279823B (zh) | 一种治疗登革热的中药组合物及其制备方法 | |
| CN106177107A (zh) | 一种治疗鼻炎的药物 | |
| CN105031397A (zh) | 一种治疗肺炎的中药及其制备方法 | |
| CN104043071A (zh) | 治疗心背彻痛的中药制剂 | |
| CN105434874A (zh) | 一种治疗毛囊炎的药物及其制备方法 | |
| CN103877518A (zh) | 一种治疗支气管炎的中药 | |
| CN103989953A (zh) | 一种治疗小儿麻痹症的中药组合物 | |
| CN104083649A (zh) | 治疗肩周炎的中药制剂 | |
| CN103736013A (zh) | 一种治疗肺结核的中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160727 |