CN105796063A - Tumor detection device - Google Patents
Tumor detection device Download PDFInfo
- Publication number
- CN105796063A CN105796063A CN201610313917.6A CN201610313917A CN105796063A CN 105796063 A CN105796063 A CN 105796063A CN 201610313917 A CN201610313917 A CN 201610313917A CN 105796063 A CN105796063 A CN 105796063A
- Authority
- CN
- China
- Prior art keywords
- laser
- unit
- tumor detection
- detection devices
- flux density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 53
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 47
- 230000008878 coupling Effects 0.000 claims abstract description 26
- 238000010168 coupling process Methods 0.000 claims abstract description 26
- 238000005859 coupling reaction Methods 0.000 claims abstract description 26
- 238000012937 correction Methods 0.000 claims abstract description 21
- 238000002604 ultrasonography Methods 0.000 claims description 55
- 230000004907 flux Effects 0.000 claims description 43
- 239000013536 elastomeric material Substances 0.000 claims description 30
- 239000000463 material Substances 0.000 claims description 25
- 238000012545 processing Methods 0.000 claims description 7
- 239000003575 carbonaceous material Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000007769 metal material Substances 0.000 claims description 3
- 239000013307 optical fiber Substances 0.000 claims description 3
- 239000004065 semiconductor Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 abstract description 3
- 239000013013 elastic material Substances 0.000 abstract 3
- 230000008859 change Effects 0.000 description 7
- 210000004881 tumor cell Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 230000010748 Photoabsorption Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000010895 photoacoustic effect Methods 0.000 description 1
- 238000004867 photoacoustic spectroscopy Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
- A61B8/085—Clinical applications involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Signal Processing (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Power Engineering (AREA)
- Artificial Intelligence (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
The invention discloses a tumor detection device and a correction method thereof, belonging to the technical field of medical equipment. The tumor detection device comprises a laser generating unit used for generating high-frequency pulse laser, a light beam coupling unit used for dividing laser beams generated by the laser generating unit into two paths, i.e., a first path of laser and a second path of laser, a correction unit comprising a standard thermal elastic material used for receiving the first path of laser, and an ultrasonic testing unit used for detecting the standard thermal elastic material and an ultrasonic wave generated by a tissue to be detected. The correction unit is used for receiving an ultrasonic pressure produced by the first path of laser, and the flow density of the first path of laser is obtained according to a value of the ultrasonic pressure and parameters of the standard thermal elastic material; the flow density of the second path of laser is obtained according to a proportional relation between the first path of laser and the second path of laser, so that the ultrasonic pressure of the tissue to be detected is further obtained. The tumor detection device solves the technical problem that the existing device is low in detection accuracy.
Description
Technical field
The invention belongs to medical instruments field, particularly to a kind of tumor detection devices.
Background technology
Malignant tumor is that treatment difficulty is relatively big at present, threatens the disease of human life.But if finding in early days and treating in time, it is possible to be greatly improved the survival rate of patient.The early diagnosis of tumor includes imaging diagnosis such as: photoacoustic imaging, Photoacoustic tomography, optoacoustic spectroscopy microscope imaging etc., wherein, photoacoustic imaging is a kind of lossless medical imaging techniques, it is based on optoacoustic effect, the short-pulse laser (optical signal) using nanosecond order irradiates biological tissue, after biological tissue absorbs short-pulse laser, cause quick thermal-elastic expansion to produce mechanical wave, thus produce ultrasound wave (photoacoustic signal).Ultrasonic detector receives the ultrasound wave produced and carries out back projection by certain algorithm, and the light in namely being organized absorbs distribution.Therefore, when the material different with identical ray energy, various different materials can produce the ultrasound wave with different pressure value.Medical research shows: cancer patient has Partial tumors cell early stage and enters blood system, tumor cell is subject to can change into heat energy by luminous energy after the laser of specific band irradiates, sending the ultrasound wave of a kind of specific wavelength during tumor cell expanded by heating, hyperacoustic frequency that this hyperacoustic frequency sends with Normocellular expanded by heating is different.Therefore, by detecting that the circulating tumor cell entered in blood becomes a key means of cancer early discovery.
But, the many materials constituting human body have low light energy absorption coefficient, compared with the blood of high-light-energy absorptance, the pressure value of the sound wave that the skin histology of low light energy absorption coefficient produces is less, thus, the ultrasound wave pressure values carrying out blood again producing after laser emission through skin is less, the minor variations of the easy input value of testing result and be a greater impact.And detect again after vein sampling dyeing in vitro, sampling dyeing course often affects cell physiological environment in vivo, and its testing result is often not accurate enough.Therefore, as how human body is object of study, carrying out at body, in real time detection tumor cell is an extremely urgent problem.
Summary of the invention
For this, the technical problem to be solved is in that the problem that existing tumor detection devices detection accuracy is not high, it is provided that the tumor detection devices that a kind of accuracy in detection is higher.
For solving above-mentioned technical problem, a kind of tumor detection devices of the present invention, including, laser generating unit, it is used for producing high-frequency pulsed lasers；Light beam coupling unit, described light beam coupling unit is used for the laser beam that described laser generating unit produces is divided into two-way, respectively first via laser and the second road laser；Correction unit, described correction unit includes the standard hot elastomeric material for receiving described first via laser；And ultrasonic detecting unit, the ultrasound wave that described ultrasonic detecting unit produces for examination criteria thermoelastic material and tissue to be detected.
Further, above-mentioned tumor detection devices also includes control unit, described control unit for selecting the pulse width of described laser beam according to tissue property to be detected, and described tissue to be detected produces the ultrasound wave with different pressure values according to the pulse width of different laser beams.
Further, in above-mentioned tumor detection devices, described control unit is additionally operable to control described laser generating unit and produces the laser beam of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, parameter according to several times ultrasound wave pressure and standard hot elastomeric material draws the flux density of several first via laser, and the flux density of several the first laser being averaged draws the flow of the first final laser.
Further, in above-mentioned tumor detection devices, described high-frequency pulsed lasers is equally divided into two-way by described light beam coupling unit, and the flux density of described first via laser and the second road laser is equal.
Further, above-mentioned tumor detection devices also includes signal processing unit and display unit, and described signal processing unit is for being converted to the signal of telecommunication by described ultrasound wave pressure values and generating ultrasonography, and described display unit is used for showing described ultrasonography.
Further, in above-mentioned tumor detection devices, described light beam coupling unit and described correction unit are packaged into integrative-structure, and described laser generating unit is connected by optical fiber with described light beam coupling unit.
Further, in above-mentioned tumor detection devices, described standard hot elastomeric material is metal material, semi-conducting material, carbon-based material or polymeric material, and described standard hot elastomeric material is shaped to membrane structure.
Present invention simultaneously discloses the bearing calibration of a kind of tumor detection devices, it includes above-mentioned tumor detection devices, described laser generating unit produces high-frequency pulsed lasers, first via laser and the second road laser it is divided into through light beam coupling unit, correction unit accepts described first via laser, described ultrasonic detecting unit detects the ultrasound wave that described standard hot elastomeric material produces, and the flux density of described first via laser is drawn according to the parameter of described ultrasound wave pressure values and standard hot elastomeric material, and the flux density of the second road laser is drawn according to the proportionate relationship between first via laser and the second road laser.
In the bearing calibration of above-mentioned tumor detection devices, the flux density of described first via laser and the second road laser is equal.
In the bearing calibration of above-mentioned tumor detection devices, described control unit controls described high-frequency pulsed lasers and produces the laser of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, draw the flux density of several first via laser according to several times ultrasound wave pressure, the flux density of several first via laser being averaged draws the flux density of final first via laser.
The technique scheme of the present invention has the advantage that compared to existing technology
(1) due to the laser intensity of existing laser generator outgoing owing to the factors such as error of dispatching from the factory there will be certain deviation, therefore, the parameter of the ultrasound wave pressure values derivation tissue to be detected produced according to laser generator product Calibration of Laser density and tissue to be detected has relatively large deviation；The tumor detection devices of the present invention includes a correction unit, and correction unit includes the standard hot elastomeric material for receiving first via laser；Make part of laser beam irradiate known standard hot elastomeric material, according to the ultrasound wave pressure values that standard spy's elastomeric material produces, calculate the laser intensity of laser beam；Due to the high-light-energy photo absorption performance of thermoelastic material, the ultrasound wave pressure of its generation is higher, it is possible to relatively accurately draw the flux density of first via laser, and draws the flux density of the second road laser according to the relation of first via laser and the second road laser；Improve the detection accuracy of tumor detection devices.
(2) in order to improve detection accuracy further, described control unit is additionally operable to control described laser generating unit and produces the laser beam of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, parameter according to several times ultrasound wave pressure and standard hot elastomeric material draws the flux density of several first via laser, and the flux density of several the first laser being averaged draws the flux density of the first final laser.The flux density being made first via laser by the above-mentioned mode averaged is more accurate.
(3) described light beam coupling unit and described correction unit are packaged into integrative-structure, both are packaged in one can ensure that the light end that of described light beam coupling unit mates with thermoelastic material during fabrication preferably, avoid both split manufactures, error during installation causes the problem that the ratio of the lighting area of first via laser and the lighting area of the second road laser is inconsistent with setting ratio, further ensures detection accuracy.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiments of the invention and in conjunction with accompanying drawing, the present invention is further detailed explanation, wherein
Fig. 1 is the systematic schematic diagram of the tumor detection devices of the present invention；
Fig. 2 is the flow chart of the tumor detection devices generation ultrasonography method of the present invention.
In figure, accompanying drawing labelling is expressed as:
10-control unit, 20-laser generating unit, 30-light beam coupling unit, 301-first via laser, 302-the second road laser, 40-corrects unit, 50-ultrasonic detecting unit, 60-signal processing unit, 70-display unit, 80-tissue to be detected.
Detailed description of the invention
Below in conjunction with accompanying drawing, technical scheme is clearly and completely described, it is clear that described embodiment is a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under not making creative work premise, broadly fall into the scope of protection of the invention.
In describing the invention, it should be noted that, orientation or the position relationship of the instruction such as term " " center ", " on ", D score, "left", "right", " vertically ", " level ", " interior ", " outward " be based on orientation shown in the drawings or position relationship; be for only for ease of the description present invention and simplifying and describe; rather than instruction or imply indication device or element must have specific orientation, with specific azimuth configuration and operation, be therefore not considered as limiting the invention.Additionally, term " first ", " second ", " the 3rd " are only for descriptive purposes, and it is not intended that indicate or hint relative importance.
In describing the invention, it is necessary to explanation, unless otherwise clearly defined and limited, term " installation ", " being connected ", " connection " should be interpreted broadly, for instance, it is possible to it is fixing connection, it is also possible to be removably connect, or connect integratedly；Can be mechanically connected, it is also possible to be electrical connection；Can be joined directly together, it is also possible to be indirectly connected to by intermediary, it is possible to be the connection of two element internals.For the ordinary skill in the art, it is possible to concrete condition understands above-mentioned term concrete meaning in the present invention.
As long as just can be combined with each other additionally, technical characteristic involved in invention described below difference embodiment does not constitute conflict each other.
The tumor detection devices of the present invention is for by using induced with laser ultrasound wave determines whether define tumor in the patient.When having the laser beam irradiation of flux density I material to be detected, material to be detected can absorb heat energy H, as shown in following equalities 1:
Equation 1:HQUOTE
Here, R represents the material to be detected reflection coefficient under specific wavelength of light, and μ represents the material to be detected absorptance under specific wavelength of light, and z represents the distance along the direction vertical relative to the surface of laser with material surface to be detected.
Additionally, as shown in equation 2, material place to be detected can the change of occurrence temperature T, and due to the change of temperature T, as illustrated by equation 3, the volume V of material to be detected can also change.
Equation 2:QUOTE
Equation 3:QUOTE
Here, k represents heat conductivity, and C represents heat propagation speed, and ρ represents the density of material to be detected, CpRepresenting the specific heat of material to be detected, β represents the corresponding hot coefficient relative to volumetric expansion.
As a result, as shown in following equalities 4, material volume to be detected change produces the sound wave with pressure P.
Equation 4:QUOTE
Here, vsRepresent the speed of sound wave.By above-mentioned equation 1-equation 4 it can be seen that induced with laser sound wave is generated as the energy of laser beam, by material to be detected and tissue resorption to be detected, and change into pressure.
Namely the present invention utilizes above-mentioned laser excitation ultrasonic wave principle to propose.It is illustrated in figure 1 the tumor detection devices of the present invention, including, laser generating unit 20, light beam coupling unit 30, correction unit and ultrasonic detecting unit 50.
Wherein, laser generating unit 20 is used for producing high-frequency pulsed lasers, and described light beam coupling unit 30 is used for the laser beam that described laser generating unit produces is divided into two-way, respectively first via laser 301 and the second road laser 302；Described correction unit 40 includes the standard hot elastomeric material for receiving described first via laser；The ultrasound wave that described ultrasonic detecting unit 50 produces for examination criteria thermoelastic material and tissue to be detected 80.
Owing to the laser intensity I of laser generating unit 20 outgoing there will be certain deviation due to the factors such as error of dispatching from the factory, the present invention is by increasing a correction unit 40, part of laser beam is made to irradiate known standard hot elastomeric material, according to the ultrasound wave pressure values that standard spy's elastomeric material produces, calculate the laser intensity of laser beam；Due to the high-light-energy photo absorption performance of thermoelastic material, the ultrasound wave pressure of its generation is higher, it is possible to relatively accurately draw the flux density of first via laser, and draws the flux density of the second road laser according to the relation of first via laser and the second road laser；Improve the detection accuracy of tumor detection devices.
The ultrasound wave pressure values produced due to the laser of different pulse widths is different, and experiments show that the pulse width of laser beam is more little, and the pressure value of induced with laser sound wave is more big, it is preferred that the pulse width of laser beam can be nanosecond or picosecond；Present invention additionally comprises control unit 10, it can select the pulse width of described laser beam according to tissue property to be detected, and described tissue 80 to be detected produces the ultrasound wave with different pressure values according to the pulse width of different laser beams.
In order to improve detection accuracy further, described control unit 10 is additionally operable to control described laser generating unit 20 and produces the laser beam of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, parameter according to several times ultrasound wave pressure and standard hot elastomeric material draws the flux density of several first via laser 301, and the flux density of several the first laser 301 being averaged draws the flux density of the first final laser.
As a kind of embodiment, described high-frequency pulsed lasers is equally divided into two-way by described light beam coupling unit 30, this mode can at the lighting area manufacturing Absent measures light beam coupling unit 30, the flux density making the described first via laser 301 by light beam coupling unit and the second road laser 302 is equal, it is to avoid the deviation that middle conversion link causes.
As the mode that another kind can be implemented, due to the low light energy absorption performance of the tissue to be detected of human body, it is also possible to control light beam coupling unit 30 and make the flux density flux density more than first via laser 301 of the second road laser 302, it is preferable that be set to integral multiple.Avoid the problem that middle conversion causes median error bigger.
The tumor detection devices of the present invention also includes signal processing unit 60 and display unit 70, and described signal processing unit 60 is for being converted to the signal of telecommunication by described ultrasound wave pressure values and generating ultrasonography, and described display unit 70 is used for showing described ultrasonography.
Described light beam coupling unit 30 is packaged into integrative-structure with described correction unit 40, both are packaged in one can ensure the lighting area of first via laser 301 and the second road laser 302 in described light beam coupling unit 30 during fabrication preferably, avoid both split manufactures, the error caused when installing, further ensures detection accuracy.
Described laser generating unit 20 is connected by optical fiber with described light beam coupling unit 30.Described standard hot elastomeric material is metal material, semi-conducting material, carbon-based material or polymeric material, and is formed as membrane structure.Such as, thermoelastic material is by metals such as Cr, Au, Al, or CNT or silicon are formed.
The present embodiment also discloses the bearing calibration of above-mentioned tumor detection devices, as in figure 2 it is shown, it comprises the following steps:
S100: described laser generating unit produces high-frequency pulsed lasers, is divided into first via laser and the second road laser through light beam coupling unit；
S110: correction unit accepts described first via laser, described ultrasonic detecting unit detects the ultrasound wave pressure that described standard hot elastomeric material produces, and the flux density of described first via laser is drawn according to the parameter of described ultrasound wave pressure values and standard hot elastomeric material
S120: draw the flux density of the second road laser after correction according to the proportionate relationship between first via laser and the second road laser.
Owing to the laser intensity of laser generating unit outgoing there will be certain deviation due to the factors such as error of dispatching from the factory, the present invention, by increasing the mode of a correction unit, draws the laser intensity of laser beam；Due to the high-light-energy photo absorption performance of thermoelastic material, the ultrasound wave pressure of its generation is higher, it is possible to relatively accurately draw the flux density of first via laser, and draws the flux density of the second road laser according to the relation of first via laser and the second road laser；Improve the detection accuracy of tumor detection devices.
As one preferred embodiment, described laser beam is equally divided into two-way by the beam coupler of above-mentioned tumor detection devices, and the flux density of first via laser and the second road laser is equal, decreases middle scaling step；Further increase detection accuracy.
Further, in order to obtain the flux density of first via laser 301 more accurately；Described control unit 10 controls described high-frequency pulsed lasers and produces the laser of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, draw the flux density of several first via laser 301 according to several times ultrasound wave pressure, the flux density of several the first laser 301 being averaged draws the flux density of final first via laser 301.
It is further comprising the steps of on the basis of above-mentioned bearing calibration that the tumor detection devices of the present invention generates ultrasonography method, as in figure 2 it is shown,
S130: tissue to be detected accepts the second road laser 302 and irradiates, and produces the second ultrasound wave；
S140: according to the flux density of the second road laser 302 and the second ultrasound wave, forms ultrasonography.
The character of tissue to be detected is drawn according to ultrasonography, the ultrasound wave of a kind of specific wavelength is formed due to tumor cell Stimulated Light after irradiating, this hyperacoustic frequency is different with Normocellular hyperacoustic frequency, it is possible to judge whether that having tumor cell exists exactly.
Obviously, above-described embodiment is only for clearly demonstrating example, and is not the restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also cannot all of embodiment be given exhaustive.And the apparent change thus extended out or variation are still among the protection domain of the invention.
Claims (10)
1. a tumor detection devices, it is characterised in that: include, laser generating unit, be used for producing high-frequency pulsed lasers；Light beam coupling unit, described light beam coupling unit is used for the laser beam that described laser generating unit produces is divided into two-way, respectively first via laser and the second road laser；Correction unit, described correction unit includes the standard hot elastomeric material for receiving described first via laser；And ultrasonic detecting unit, the ultrasound wave that described ultrasonic detecting unit produces for examination criteria thermoelastic material and tissue to be detected.
2. tumor detection devices according to claim 1, it is characterized in that: also include control unit, described control unit for selecting the pulse width of described laser beam according to tissue property to be detected, and described tissue to be detected produces the ultrasound wave with different pressure values according to the pulse width of different laser beams.
3. tumor detection devices according to claim 1, it is characterized in that: described control unit is additionally operable to control described laser generating unit and produces the laser beam of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, parameter according to several times ultrasound wave pressure and standard hot elastomeric material draws the flux density of several first via laser, and the flux density of several the first laser being averaged draws the flow of the first final laser.
4. tumor detection devices according to claim 1, it is characterised in that: described high-frequency pulsed lasers is equally divided into two-way by described light beam coupling unit, and the flux density of described first via laser and the second road laser is equal.
5. tumor detection devices according to claim 1, it is characterized in that: also include signal processing unit and display unit, described signal processing unit is for being converted to the signal of telecommunication by described ultrasound wave pressure values and generating ultrasonography, and described display unit is used for showing described ultrasonography.
6. tumor detection devices according to claim 1, it is characterised in that: described light beam coupling unit and described correction unit are packaged into integrative-structure, and described laser generating unit is connected by optical fiber with described light beam coupling unit.
7. tumor detection devices according to claim 1, it is characterised in that: described standard hot elastomeric material is metal material, semi-conducting material, carbon-based material or polymeric material, and described standard hot elastomeric material is shaped to membrane structure.
8. the bearing calibration of a tumor detection devices, it is characterized in that: it includes the tumor detection devices described in claim 1, described laser generating unit produces high-frequency pulsed lasers, first via laser and the second road laser it is divided into through light beam coupling unit, correction unit accepts described first via laser, described ultrasonic detecting unit detects the ultrasound wave that described standard hot elastomeric material produces, and the flux density of described first via laser is drawn according to the parameter of described ultrasound wave pressure values and standard hot elastomeric material, and the flux density of the second road laser is drawn according to the proportionate relationship between first via laser and the second road laser.
9. the bearing calibration of tumor detection devices according to claim 8, it is characterised in that: the flux density of described first via laser and the second road laser is equal.
10. the bearing calibration of tumor detection devices according to claim 8, it is characterized in that: described control unit controls described high-frequency pulsed lasers and produces the laser of several times difference pulse width, described standard hot elastomeric material produces the ultrasound wave with different pressure values according to the pulse width of different laser beams, draw the flux density of several first via laser according to several times ultrasound wave pressure, the flux density of several first via laser being averaged draws the flux density of final first via laser.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610313917.6A CN105796063B (en) | 2016-05-13 | 2016-05-13 | Tumor detection devices |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610313917.6A CN105796063B (en) | 2016-05-13 | 2016-05-13 | Tumor detection devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105796063A true CN105796063A (en) | 2016-07-27 |
| CN105796063B CN105796063B (en) | 2018-10-02 |
Family
ID=56456683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610313917.6A Active CN105796063B (en) | 2016-05-13 | 2016-05-13 | Tumor detection devices |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105796063B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107692968A (en) * | 2017-09-26 | 2018-02-16 | 李铭 | A kind of tumor detection devices |
| CN112274113A (en) * | 2020-11-25 | 2021-01-29 | 广东普洛宇飞生物科技有限公司 | Photoacoustic cell detection device and cell detection method |
| CN113081043A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Ultrasonic imaging detector |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1862247A (en) * | 2006-05-30 | 2006-11-15 | 华南师范大学 | Multi-channel electronic parallel scanning photoacoustic real-time tomo graphic-imaging method and apparatus thereof |
| CN102596049A (en) * | 2009-10-29 | 2012-07-18 | 佳能株式会社 | Photo-acoustic device |
| US20130237799A1 (en) * | 2012-03-09 | 2013-09-12 | Canon Kabushiki Kaisha | Object information acquiring apparatus and calibration device |
| US20130276542A1 (en) * | 2011-11-02 | 2013-10-24 | Seno Medical Instrument, Inc. | Light output calibration in an optoacoustic system |
| CN104135936A (en) * | 2012-02-13 | 2014-11-05 | 富士胶片株式会社 | Photoacoustic visualization method and device |
| CN105310720A (en) * | 2014-08-04 | 2016-02-10 | 佳能株式会社 | Object information acquiring apparatus |
-
2016
- 2016-05-13 CN CN201610313917.6A patent/CN105796063B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1862247A (en) * | 2006-05-30 | 2006-11-15 | 华南师范大学 | Multi-channel electronic parallel scanning photoacoustic real-time tomo graphic-imaging method and apparatus thereof |
| CN102596049A (en) * | 2009-10-29 | 2012-07-18 | 佳能株式会社 | Photo-acoustic device |
| US20130276542A1 (en) * | 2011-11-02 | 2013-10-24 | Seno Medical Instrument, Inc. | Light output calibration in an optoacoustic system |
| CN104135936A (en) * | 2012-02-13 | 2014-11-05 | 富士胶片株式会社 | Photoacoustic visualization method and device |
| US20130237799A1 (en) * | 2012-03-09 | 2013-09-12 | Canon Kabushiki Kaisha | Object information acquiring apparatus and calibration device |
| CN105310720A (en) * | 2014-08-04 | 2016-02-10 | 佳能株式会社 | Object information acquiring apparatus |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107692968A (en) * | 2017-09-26 | 2018-02-16 | 李铭 | A kind of tumor detection devices |
| CN112274113A (en) * | 2020-11-25 | 2021-01-29 | 广东普洛宇飞生物科技有限公司 | Photoacoustic cell detection device and cell detection method |
| CN113081043A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Ultrasonic imaging detector |
| CN113081043B (en) * | 2021-04-12 | 2022-07-05 | 北京航空航天大学 | Ultrasonic imaging detector |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105796063B (en) | 2018-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2494923B1 (en) | Photo-acoustic device | |
| Manohar et al. | Photoacoustics: a historical review | |
| Daoudi et al. | Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging | |
| Estrada et al. | Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution | |
| Shah et al. | Photoacoustic imaging and temperature measurement for photothermal cancer therapy | |
| Xi et al. | Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging | |
| JP5349839B2 (en) | Biological information imaging device | |
| Wang et al. | Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector | |
| CN105050485B (en) | Compact lasers and efficient pulse delivery for photoacoustic imaging | |
| Li et al. | Time-domain terahertz optoacoustics: manipulable water sensing and dampening | |
| EP2319415A1 (en) | Device for processing photo acoustic information relating to living body and method for processing photo acoustic information relating to living body | |
| Ke et al. | Photoacoustic thermography of tissue | |
| US8654613B2 (en) | Measuring apparatus | |
| Payne et al. | Optoacoustic tomography using time-resolved interferometric detection of surface displacement | |
| JP2011229735A (en) | Measuring apparatus | |
| JP5773578B2 (en) | SUBJECT INFORMATION ACQUISITION DEVICE, CONTROL METHOD AND PROGRAM FOR SUBJECT INFORMATION ACQUISITION DEVICE | |
| CN105796063A (en) | Tumor detection device | |
| JP2013078463A (en) | Acoustic wave acquiring apparatus | |
| Shintate et al. | Development of optical resolution photoacoustic microscopy with sub-micron lateral resolution for visualization of cells and their structures | |
| US20150182123A1 (en) | Object information acquiring apparatus and control method for the object information acquiring apparatus | |
| Patterson et al. | Optoacoustic characterization of prostate cancer in an in vivo transgenic murine model | |
| CN116392079A (en) | Ultrasonic array patch and wearable photoacoustic/ultrasonic imaging system based on patch | |
| JP6049780B2 (en) | Photoacoustic device | |
| Xu et al. | Investigation of a diffuse optical measurements-assisted quantitative photoacoustic tomographic method in reflection geometry | |
| Erfanzadeh et al. | Improvement and evaluation of a low-cost laser diode photoacoustic microscopy system for ovarian tissue imaging |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210209 Address after: 102600 Room 403, unit 1, 15th floor, changfengyuan, Huangcun Town, Daxing District, Beijing Patentee after: Du Lihong Address before: Affiliated Hospital of Jining Medical College, 89 Guhuai Road, Rencheng District, Jining City, Shandong Province 272000 Patentee before: Li Ruidong |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211221 Address after: 274000 east of Taiwan East Road and north of Hongze Road, Heze City, Shandong Province Patentee after: Heze Runquan Chemical Co.,Ltd. Address before: 102600 Room 403, unit 1, 15th floor, changfengyuan, Huangcun Town, Daxing District, Beijing Patentee before: Du Lihong |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220121 Address after: 264209 room 1203, No. 666-1, Keji Road, torch high tech Industrial Development Zone, Weihai City, Shandong Province Patentee after: Weihai Tianxin Medical Instrument Co.,Ltd. Address before: 274000 east of Taiwan East Road and north of Hongze Road, Heze City, Shandong Province Patentee before: Heze Runquan Chemical Co.,Ltd. |