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CN105795145A - Feed additive capable of reducing aggressivity of mixed groups of pigs and preparation method of feed additive - Google Patents

Feed additive capable of reducing aggressivity of mixed groups of pigs and preparation method of feed additive Download PDF

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Publication number
CN105795145A
CN105795145A CN201610216533.2A CN201610216533A CN105795145A CN 105795145 A CN105795145 A CN 105795145A CN 201610216533 A CN201610216533 A CN 201610216533A CN 105795145 A CN105795145 A CN 105795145A
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parts
feed additive
group
pig
radix
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Inventor
陈芳宁
周盛昌
肖丽萍
姜文
施建成
温庆琪
艾春香
吴有林
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Fujian Aonong Biological Technology Group Co Ltd
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Fujian Aonong Biological Technology Group Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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Abstract

The invention discloses a feed additive capable of reducing aggressivity of mixed groups of pigs. The feed additive is prepared from raw materials in parts by weight as follows: 9-20 parts of Chinese thorowax roots, 7-15 parts of nutgrass galingale rhizomes, 8-15 parts of rhizoma chuanxiong, 4-10 parts of bitter orange stir-fried with bran, 7-16 parts of red peony roots, 8-18 parts of dried orange peel stir-fried vinegar, 4-10 parts of radix glycyrrhizae preparata, 5-12 parts of mint, 6-15 parts of combined spicebush roots, 5-12 parts of hawthorn fruits, 1-5 parts of chrysanthemums, 3-12 parts of cape jasmine, 3-6 parts of szechwan Chinaberry fruits, 5-10 parts of baical skullcap roots, 2-4 parts of L-tryptophan and 0.5-1 part of vitamin B. The invention further discloses a preparation method. The feed additive can sooth the liver, regulate qi and promote blood circulation to relieve pain, has a good regulation function on tension guard, emotion depression, irritability and bellicosity caused by pig group mixing under different production demands, the number of injured and dead pigs due to mutual fight of the pig groups is effectively reduced, the occurrence rate of tail baiting behavior, allotriophagia and other bad behaviors is reduced, few side effects are caused, the preparation cost is lower, and the feed additive is suitable for popularization and application.

Description

A kind of reduction pig mixes aggressive feed additive of group and preparation method thereof
Technical field
The present invention relates to a kind of feed additive and preparation method thereof, refer in particular to a kind of reduction pig and mix group's aggressivity Feed additive and preparation method thereof.
Background technology
In intensive culture pig farm, in order to make full use of pig house space, carry out high-volume fattening, start one When taking turns the new breeding cycle and during transportation and pig driven lairage, it is necessary to pig is carried out mixed group.But, When brood swinery suddenly mixes group with unfamiliar pig, usually can occur mutually to fight and the aggressive behavior such as bait, right The economic benefit on pig farm and the welfare health of pig bring series of negative to affect.Pig one in centralization-breeding factory Life would generally be experienced and mix group for several times.Through report, the most brood swinery mutual short time attacks and fights for a long time Phenomenon often occur after mixed group, and often result in skin physical injury in various degree.Behavior of fighting occurs When close to slaughter weight, owing to attack both sides are from great, the trunk damage caused and fatigue can directly be led Cause decline and the economic loss of meat quality.It is in the body that the pig in all ages and classes stage is caused because accusing each other It is easily caused injured individual resistance and immunity degradation with psychic trauma.Fight in generating process, substantial amounts of body Action can increase the quantity of heat production of body and cause the reduction of efficiency of feed utilization, the result accused each other after simultaneously mixing group Also can form hierarchy, the feed intake of suppression part pig and rate of growth in swinery, make to grow between swinery individuality Diversity factor is gradually increased, and reduces swinery overall manufacturing performance on a large scale, pig farm is caused economic loss.
Generally in Compact Develop, typically in piglet is born latter 24 hours, it is cut at tooth and docking Reason, with the efficient aggressive behavior solved between swinery individuality and tail biting behavior.But, send out through long-term practice research Existing, cut tooth for piglet and docking exists many disadvantages, as a example by the latter, pigtail is an important composition portion of pig Point.First, the tail point cave that pigtail is most advanced and sophisticated is a critical function cave prevented and cured diseases in Chinese veterinarian's acupuncture and moxibustion therapy Position, it cures mainly the heatstroke of pig, flu, rheumatism, lung is yellow, eat less, suffer from abdominal pain, poisoning etc.;Secondly, pigtail exists In veterinary clinic diagnosis, there is important reference significance.When pig is in health status, its tail is vacillated now to the left, now to the right not Stop, otherwise, the flaccid tail of sick pig is sagging, stops swinging;According to whether there being loose stool to assist on pigtail sentence The gastrointestinal tract conditions of this pig disconnected;How many without hair or gross weight according to pigtail root hairiness, can be with in auxiliary judgment pig body Outer with or without parasite.Again, pigtail swings back and forth and can drive the mosquito fly horsefly biting rear-guard just to ensure pig Often search for food and have a rest the most infected, reducing the risk of cause of disease invasion pig body.It addition, outside the most protected sow of pigtail Pudendum and the effect of prompting pig growth performance.It is noted that through on a large scale, repeatedly repeatedly practise, Piglet is implemented biting behavior and causes open wound, thus increase pig streptococcicosis, Haemophilus parasuis and The infection morbidity probability of eperythrozoonosis, it is possible to further result in abuse and the drug residue index of antibiotic Rising.Therefore, before piglet 3 age in days to its implement docking cut tooth art, for solve pig aggressive behavior and Tail biting behavior is a method cured the symptoms, not the disease, and can bring a series of animal welfare issues.
Therefore, develop after a kind of feed additive relaxes reduction in the way of moderate notoxic side effect pig mixes group Aggressivity cuts tooth docking art with what the existing pig farm of replacement was implemented, is reducing pig farm operating cost, is increasing economic efficiency, The aspects such as the physically and mentally healthy degree of lifting swinery and welfare have important practical value and dissemination.
Summary of the invention
Offer one reduction pig is provided and mixes the aggressive feed additive of group and preparation thereof Method.
In order to achieve the above object, technical scheme is as follows:
A kind of reduction pig mixes the aggressive feed additive of group, the most formulated by following raw materials according: Radix Bupleuri 9-20 part, Rhizoma Cyperi 7-15 part, Rhizoma Chuanxiong 8-15 part, Fructus Aurantii (parched with bran) 4-10 part, Radix Paeoniae Rubra 7-16 part is old Skin (vinegar-fried) 8-18 part, Radix Glycyrrhizae Preparata 4-10 part, Herba Menthae 5-12 part, Radix Linderae 6-15 part, Fructus Crataegi 5-12 part, Flos Chrysanthemi 1-5 part, Fructus Gardeniae 3-12 part, Fructus Toosendan 3-6 part, Radix Scutellariae 5-10 part, L-Trp 2-4 part, dimension Raw element B120.5-1 part.
Preferably, a kind of reduction pig mixes the aggressive feed additive of group, and the weight portion of its raw material is: Radix Bupleuri 16 parts, Rhizoma Cyperi 11 parts, Rhizoma Chuanxiong 11 parts, Fructus Aurantii (parched with bran) 8 parts, Radix Paeoniae Rubra 12 parts, Pericarpium Citri Reticulatae (vinegar-fried) 15 parts, Radix Glycyrrhizae Preparata 7.5 parts, Herba Menthae 7 parts, the Radix Linderae 7 parts, Fructus Crataegi 8 parts, Flos Chrysanthemi 3 parts, Fructus Gardeniae 6 parts, Fructus Toosendan 4 parts, Radix Scutellariae 7 parts, L-Trp 2.5 parts,VitaminB120.6 part.
Described a kind of reduce pig and mix the preparation method of the aggressive feed additive of group and comprise the steps:
Step one, stir-baked Fructus Aurantii in bran: the Fructus Aurantii after cutting, to there being cigarette, is put into smoked therewith in pot stir-fry by hot pot cooked wheat bran Being buff to Fructus Aurantii surface, the sieve that takes the dish out of the pot removes Testa Tritici, cools stand-by;
Step 2, vinegar-fried Pericarpium Citri Reticulatae: Pericarpium Citri Reticulatae vinegar is soaked about 10min, places into fried dry in hot pot, cool Stand-by;
Step 3, weighs Chinese medicinal components: Radix Bupleuri, Rhizoma Chuanxiong and Herba Menthae;It is dried and pulverized 100 mesh sieves, so After carry out supercritical carbon dioxide cyclic countercurrent extraction and separation, by collect gained extract stand-by;
Step 4, weighs Chinese medicinal components: Rhizoma Cyperi, Radix Paeoniae Rubra, the Fructus Aurantii of step one gained, step 2 gained old Skin, Flos Chrysanthemi, Radix Scutellariae, Radix Glycyrrhizae Preparata, Fructus Crataegi, the Radix Linderae, Fructus Gardeniae and Fructus Toosendan are dried in 65 DEG C of baking ovens, super Crushing of Ultrafine crosses 100 mesh sieves, and the medicated powder stirred is stand-by;
Step 5, uniformly mixes the extract of step 3 with the medicated powder of step 4, and lyophilization obtains lyophilized powder, Stand-by;
Step 6, weighs L-Trp and vitamin B12
Step 7, uniformly mixes the lyophilized powder of step 5 with each component of step 6, obtains the feedstuff of the present invention Additive.
Wherein, the optimum condition of the extraction process used by step 3 is extracting pressure 35MPa, extraction temperature 45 DEG C, extraction time 2h, CO2Flow 8L/h.
Below each component in prescription of the present invention is described in detail.
Radix Bupleuri: bitter in the mouth, cold nature;Return liver, gallbladder meridian.There are reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, the merit of ascending up spleen-Qi and Yang Effect.It is usually used in cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis etc..Literary composition The data of offering shows, people cures and also do not dredges with bupleurum powder for relieving liver-qi plus-minus side treatment stagnation of liver-QI on clinical medicine, depressed, Drowsiness anorexia, unhappy anxiety, rattiness, and the depression that defines clinically and obsession.
Rhizoma Cyperi: acrid in the mouth, micro-hardship, micro-sweet, property is put down;Return liver, spleen, tri-jiao channel.There is dispersing the stagnated live-QI to relieve the stagnation of QI, width of regulating the flow of vital energy In effect.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, and distension aches Pain etc..
Rhizoma Chuanxiong: acrid in the mouth, warm in nature;Enter liver, gallbladder meridian.Having activating QI to alleviate the depression, method wind-dryness is wet, effect of promoting blood circulation and stopping pain. Being usually used in menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia. Documents and materials show, Rhizoma Chuanxiong has obvious sedation to central nervous system, when a small amount of Rhizoma Chuanxiong volatile oil is a small amount of Activity to animal brain is inhibited, and to medulla oblongata respiratory center, vasomotor center and spinal reflex Maincenter has excitation.
Fructus Aurantii (parched with bran): bitter in the mouth, pungent, sour, warm in nature;Return spleen, stomach warp.There are regulating the flow of QI to ease the stomach, the stagnant relieving distension of row Effect.Coerce the stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion for breast, stop in phlegm retention, gastroptosis, proctoptosis, sub-official De-.
Radix Paeoniae Rubra: bitter in the mouth, cold nature;Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.Seek for thermal man Blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass is suffered from abdominal pain, is fallen and flutter damage Wound, carbuncle skin infection.
Pericarpium Citri Reticulatae (vinegar-fried): bitter in the mouth, pungent, warm in nature;Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the merit of drying dampness to eliminate phlegm Effect.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Radix Glycyrrhizae Preparata: sweet in the mouth, property is put down;GUIXIN, spleen, lung, stomach warp.There is spleen reinforcing stomach function regulating, effect of Yiqi and vein recovery. For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Herba Menthae: acrid in the mouth, cool in nature;Enter lung, Liver Channel.There is dispelling wind and heat pathogens, the clear profit head, sore-throat relieving rash, soothing the liver Effect of circulation of qi promoting.Cure mainly affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, Urticaria, epidemic febrile disease is from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
The Radix Linderae: acrid in the mouth, warm in nature;Return lung, spleen, kidney, bladder warp.There are promoting the circulation of QI to relieve pain, effect of warming kidney for dispelling cold. For QI stagnated by cold, chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold abdomen Bitterly.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature;Return spleen, stomach, Liver Channel.There are promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, change turbid Effect of blood fat reducing.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate Twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.
Flos Chrysanthemi: bitter in the mouth, sweet, cold nature;Return lung, Liver Channel.There are scattered wind heat clearing away, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing Effect.Cure mainly anemopyretic cold, epidemic febrile disease from the beginning of, dizziness due to hyperactivity of liver-YANG, liver-wind excess syndrome, conjunctival congestion is dim-sighted, sore and toxic.
Fructus Gardeniae: bitter in the mouth, cold in nature.Enter the heart, liver, lung, stomach warp.There are pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing heat from blood solution Effect of poison.Cure mainly calentura vexed, liver-fire conjunctival congestion, headache, damp and hot yellow infantile malnutrition, stranguria, dysentery hematuria, dispute Raw skin ulcer, sore swollen toxin, sprain and swell and ache.
Fructus Toosendan: bitter in the mouth, cold in nature;Return liver, small intestinal, bladder warp.Soothing the liver expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing. For pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation.
Radix Scutellariae: bitter in the mouth, cold in nature;Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is a heat clearing and damp drying, eliminating fire and detoxication, Hemostasis, antiabortive effect.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, lung-heat Cough, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Tryptophan: research both at home and abroad shows, strengthens the horizontal proportion of tryptophan, except significantly improving in daily ration Outside daily gain, also it is remarkably improved hypothalamus 5-hydroxy tryptamine level, substantially reduces pig to environment (department companion and pig house Cloth glove) the investigatory reaction activity time, reduce the Observation on Specificity of Blood-sucking of pig, reduce the tail biting of pig and the generation of pica, Reduce the persistent period accused each other of pig, to a certain degree reduce mixed group pig and fight behavior or severity.
VB12: also known as cobalamine, it is that nervous function perfects indispensable vitamin, participates in nervous tissue The formation of middle a kind of lipoprotein, has maintenance nervous system health, the sedation of impatience of releiving.Can be right The new mixed dysphoric emotion of group pig and attack emotion have certain regulation and control effect.
In inventive formulation, the mutual compatibility of each component has depressed liver-energy dispersing and QI regulating, the effect of promoting blood circulation and stopping pain, and effectively regulation is also Improve pig depressed emotion after mixed group, the state that irritability is belligerent, the negative reaction nervous to new mixed group's pig irritability and The anxiety separated with sow after wean and depressive emotion have good effect, can be improved new mixed by ordinary meal The pattern of getting along of group pig, can reduce the most bloodthirsty to a certain extent, tail biting, and male servant stings, and does not stop to yelp and pica Deng misconduct, and pig accuses each other the occurrence frequency of behavior, attacks persistent period and severity of fighting, Struggle against and the injured or quantity of dead individuals because of mutually male servant in reducing in swinery, can avoid or reduce use and cut tooth docking Processing mode reduces tail biting behavior and aggressive behavior, and in the centralization-breeding factory production of pig is greatly improved Performance and animal welfare.And this invention toxic and side effects is little, drug residue free, cost is relatively low, only before new mixed group Two weeks after supplies, and is suitable for popularization and application.
After using such scheme, the invention have the advantages that
One, the new mixed group pig emotion restless of regulation;
Two, the incidence rate of the behavior of fighting of new mixed group pig, persistent period and intensity are greatly reduced;
Three, docking art is substituted with the tail biting behavior of pig in solution pig farm, the production performance of raising pig and animal welfare.
Detailed description of the invention
The each ingredients weight parts of each embodiment such as table 1
Table 1
Embodiment one Embodiment two Embodiment three Embodiment four
Recipe ingredient Weight portion Weight portion Weight portion Weight portion
Radix Bupleuri 9 12 16 20
Rhizoma Cyperi 7 9 11 15
Rhizoma Chuanxiong 8 10 11 15
Fructus Aurantii (parched with bran) 4 6 8 10
Radix Paeoniae Rubra 7 9 12 16
Pericarpium Citri Reticulatae (vinegar-fried) 8 11 15 18
Radix Glycyrrhizae Preparata 4 6 7.5 10
Herba Menthae 5 8 10 12
The Radix Linderae 6 8 11 15
Fructus Crataegi 5 7 8 10
Flos Chrysanthemi 1 2 3 5
Fructus Gardeniae 3 5 9 12
Fructus Toosendan 3 4 5 6
Radix Scutellariae 5 7 8 10
L-Trp 2 3 3.5 4
Vitamin B12 0.5 0.7 0.8 1
This reduction pig mixes the preparation method of the aggressive feed additive of group and comprises the steps:
One, stir-baked Fructus Aurantii in bran: the Fructus Aurantii after cutting, to there being cigarette, is put into smoked therewith in pot stir-fry to trifoliate orange by hot pot cooked wheat bran Shell surface is buff, and the sieve that takes the dish out of the pot removes Testa Tritici, cools stand-by;
Two, vinegar-fried Pericarpium Citri Reticulatae: Pericarpium Citri Reticulatae vinegar is soaked about 10min, places into fried dry in hot pot, cool stand-by
Three, Chinese medicinal components is weighed: Radix Bupleuri, Rhizoma Chuanxiong, Herba Menthae;It is dried and pulverized 100 mesh sieves, then enter Row supercritical carbon dioxide cyclic countercurrent extraction and separation, extractant condition used: extracting pressure 35MPa, Extraction temperature 45 DEG C, extraction time 2h, CO2Flow 8L/h, by stand-by for the extract collecting gained;
Four, weighing Chinese medicinal components: Rhizoma Cyperi, Radix Paeoniae Rubra, Fructus Aurantii (by step one gained), Pericarpium Citri Reticulatae is (by step 2 Gained), Flos Chrysanthemi, Radix Scutellariae, Radix Glycyrrhizae Preparata, Fructus Crataegi, the Radix Linderae, Fructus Gardeniae, Fructus Toosendan dries in 65 DEG C of baking ovens, Micronizing crosses 100 mesh sieves, stirs stand-by;
Five, uniformly being mixed with the medicated powder of step 4 by the extract of step 3, lyophilization obtains lyophilized powder, treats With;
Six, L-Trp is weighed, VB12
Seven, uniformly being mixed with each component of step 6 by the lyophilized powder of step 5, the feedstuff obtaining the present invention adds Agent.
Using effect is tested
1, pilot project and standard:
(1) performance test: include average daily gain, average daily ingestion amount and feedstuff-meat ratio.
(2) mensuration of Determination of cortisol in blood plasma
Hydrocortisone, has another name called hydrocortisone, is the main component of glucocorticoid.When occur negatively stress emotion, During such as lather, nervous indignation, the rising immediately that the Determination of cortisol in blood or saliva is reactive.Therefore Can judge whether pig is in negative emotions state by the content of detection hydrocortisone.
(3) skin injury
The height of attack level in swinery can be judged according to pig skin surface degree of impairment.Judgment criteria such as following table Shown in (being shown in Table 2).
The standards of grading of table 2 pig physical injury degree
2, experimental basis Diet Formula and trophic level
Table 3 experimental basis Diet Formula and trophic level
Note: vitamin and microelement mixture includes: Cu 150mg, Fe 150mg, Zn 180mg, Mn 50mg, Co 0.3mg, Se 0.3mg、I 0.3mg、VA 6500U、VD3 1750U、VE 20U、VK3 3.5mg、VB1 2.8mg、VB2 6.2mg、 Nicotinic acid 33mg, pantothenic acid 18mg, VB63.5mg, folic acid 0.85mg, biotin 0.06mg, VB12 35mg。
3, experiment
Test site: intensive scale kind pig farm, Fujian;
Test period: 28 days;
Subjects: what 1 monthly age that each condition is close was not carried out cutting tooth docking art does not turns group Duroc piglet 20;
Test method:
These 20 piglets are randomly divided into four groups, often group 5.Early stage sow respective with it and brood piglet Common raising, feeds common commercially available piglet diet (being shown in Table three), after the laundering period of one week, and respectively will be every Group pig is mixed group feeding and is supported, and adds the embodiment one, two, three and four in the present invention respectively in its basal diet. Additive capacity is 2Kg/ ton, feeds 21 continuously.Within first week after mixed group, put down with within the 3rd week, recording this week respectively The weight values that all increases day by day and average daily ingestion amount, and in the first weekend and the 3rd the morning at weekend 10:00 gather saliva, from Use radioimmunoassay method Determination of cortisol after the heart, check simultaneously and record the skin injury feelings of each group of piglet Condition, marks with reference to evaluation criterion to often organizing all pigs.
Result of the test:
Table 4 preliminary experiment each embodiment application effectiveness indicator changes
Note: same list same letter represents that difference is not notable (P>0.05), with string mark difference letter representation significant difference (P<0.05).
From table 4 result, the average daily progression rate of embodiment three groups is significantly higher than other each embodiment groups (P<0.05);The feedstuff-meat ratio of embodiment three groups simultaneously, salivary cortisol content rate of descent and skin injury degree Scoring is all substantially less than other each embodiment groups (P < 0.05).And embodiment one group and embodiment two groups are at material Meat ratio, salivary cortisol content and these several indexs of skin injury degree are without significant difference (P > 0.05);Implement There were significant differences (P < 0.05), in negative in the index of rate of body weight gain and meat feed ratio with embodiment three groups for example four groups Pass relation (P < 0.05).Therefore illustrating, embodiment one and two slows down new mixed group's anxiety feelings preventing aggressive behavior Thread aspect is not sufficiently effective, though embodiment four has the strongest tranquillizing and allaying excitement effect, but other health indicators is produced pair and makees With, and embodiment three is put up the best performance in medication effect, therefore selects the formula of embodiment three to carry out next step real Test.
4, embodiment three effect and conventional treatment method comparative experiments
Test site: intensive scale kind pig farm, Fujian;
Test period: 35 days;
Subjects: 1 monthly age that each condition is close does not turns group Duroc piglet 30, wherein 10 3 Once doing before age in days and cut tooth docking operation, other 20 then retain canine tooth and tail;
Detection method:
The piglet that these 20 retain canine tooth and tail is randomly divided into two groups, often group 10, with other 10 Head once did piglet three the detection groups of composition cutting tooth docking art: process group is to carry out before 3 ages in days cutting tooth docking The piglet of process, test group (adding the embodiment of the present invention three formula in daily ration), blank group.Early stage with Its respective sow and brood piglet are raised jointly, feed common commercially available piglet diet (being shown in Table three), Jing Guoyi After the laundering period in week, will often organize pig and mix group feeding respectively and support, process group and the commercially available common piglet base of control group fed Plinth daily ration, is added with the embodiment of the present invention three formulation product, additive in the common piglet basal diet of test group Amount is 2Kg/ ton, feeds 21 continuously.Record average daily gain this week value the previous day in mixed group to adopt with average day Appetite, and gather saliva with detection 10:00 in morning day, use radioimmunoassay method Determination of cortisol after being centrifuged, Check simultaneously and record the skin injury situation of each group of piglet, comment with reference to evaluation criterion often organizing all pigs Point.In latter first week, second week, within the 3rd week, search for food with average day with 4th week record average daily gain this week value Amount, and in per 10:00 collection in the morning at weekend saliva, after being centrifuged, use radioimmunoassay method Determination of cortisol, Check simultaneously and record the skin injury situation of each group of piglet, comment with reference to evaluation criterion often organizing all pigs Point.
The change of each Testing index of table 5
Note:a,b,cRepresenting that colleague's data difference is notable (P<0.05), colleague's same letter represents that difference is not notable (P>0.05).
From table 5 result, for production performance index changes, the initial weight of first three group of mixed group is without significantly Difference (P > 0.05), in first week on-test, each index of production performance of three groups is the most all without significance difference Different (P > 0.05).But from the beginning of second week, the feed intake of test group is significantly higher than process group and matched group (P < 0.05), and in test group pig feed intake difference value to be substantially less than the feed intake of process group and matched group poor Different value (P < 0.05);When the 3rd week, the weightening finish amplitude of test group is significantly higher than process group and matched group (P < 0.05), In test group, the individual variation of pig weightening finish is also significantly lower than process group and matched group weightening finish difference (P < 0.05), Meanwhile, the feedstuff-meat ratio of test group compares process group and matched group is significantly reduced (P < 0.05);And test group Pig end be heavily significantly higher than process group and matched group (P < 0.05), and between individuality weight differences value significantly less than Another two groups (P < 0.05).
For the detection of Determination of cortisol in saliva, the initial salivary cortisol content and first of mixed first three group of group The salivary cortisol content in week, all without significant difference (P > 0.05), starts the average saliva of test group from second week Determination of cortisol is substantially less than process group and matched group, and after the 3rd week, the salivary cortisol content of matched group is notable Higher than process group and test group.It is significantly reduced pig anxiety fear emotion after illustrating to add additive of the present invention Sedation effect.
Table 5 data are 0 (having no any injury response) it is also shown that mix the scoring of group's first three groups pig physical injury, And first Wednesday group Injury score difference notable (P > 0.05);During second week, matched group physical injury degree It is significantly higher than process group and test group (P < 0.05);But started off-test, test group pig from the 3rd week Physical injury degree is substantially less than process group and matched group (P < 0.05), and this physical injury of two groups scoring nothing Significant difference (P > 0.05).
In general, data show that additive of the present invention can significantly reduce new mixed group's pig aggressivity, attack strength and Frequency, significantly alleviates and prevents pig physical injury degree;Dispersing the stagnated live-QI to relieve the stagnation of QI, tranquillizing and allaying excitement, skin in saliva Matter alcohol content is greatly lowered the emotion of the impatient irritability showing newly to mix group's pig and obtains effectively easing up and dredging;Cause The conflict fighting for food generation substantially reduces so that feed intake equilibrium individual in swinery increases, weightening finish amplitude increase, Individual variation value reduces;The more important thing is, additive of the present invention can the growth performance of excellent pig and feed conversion rate. Utilize additive of the present invention can effectively make up tradition pig farm used cut tooth docking art to pig bring negative Impact, and on the basis of lower-cost, effectively improve pig production performance and disease resistance, commercially There is considerable application prospect.

Claims (6)

1. a reduction pig mixes the aggressive feed additive of group, it is characterised in that: by following raw materials according by weight Part is formulated: Radix Bupleuri 9-20 part, Rhizoma Cyperi 7-15 part, Rhizoma Chuanxiong 8-15 part, and stir-baked Fructus Aurantii in bran 4-10 part is red Chinese herbaceous peony 7-16 part, vinegar-fried Pericarpium Citri Reticulatae 8-18 part, Radix Glycyrrhizae Preparata 4-10 part, Herba Menthae 5-12 part, Radix Linderae 6-15 part, mountain Short, bristly hair or beard 5-12 part, Flos Chrysanthemi 1-5 part, Fructus Gardeniae 3-12 part, Fructus Toosendan 3-6 part, Radix Scutellariae 5-10 part, L-Trp 2-4 part, vitamin B120.5-1 part.
2. a kind of reduction pig as claimed in claim 1 mixes the aggressive feed additive of group, it is characterised in that: The weight portion of raw material is: Radix Bupleuri 16 parts, Rhizoma Cyperi 11 parts, Rhizoma Chuanxiong 11 parts, stir-baked Fructus Aurantii in bran 8 parts, Radix Paeoniae Rubra 12 Part, vinegar-fried Pericarpium Citri Reticulatae 15 parts, Radix Glycyrrhizae Preparata 7.5 parts, Herba Menthae 7 parts, the Radix Linderae 7 parts, Fructus Crataegi 8 parts, Flos Chrysanthemi 3 Part, Fructus Gardeniae 6 parts, Fructus Toosendan 4 parts, Radix Scutellariae 7 parts, L-Trp 2.5 parts,VitaminB120.6 part.
3. a kind of reduction pig as claimed in claim 1 mixes the aggressive feed additive of group, it is characterised in that: Preparation method comprises the steps:
Step one, stir-baked Fructus Aurantii in bran: take Fructus Aurantii, to fry to complexion changed deep according to parched with bran method, the sieve that takes the dish out of the pot removes Testa Tritici, cools and treats With;
Step 2, vinegar-fried Pericarpium Citri Reticulatae: take Pericarpium Citri Reticulatae, fry to complexion changed deep according to vinegar-fried method, cool stand-by;
Step 3, weighs Chinese medicinal components: Radix Bupleuri, Rhizoma Chuanxiong and Herba Menthae;It is dried and pulverized 100 mesh sieves, so After carry out supercritical carbon dioxide cyclic countercurrent extraction and separation, by collect gained extract stand-by;
Step 4, weighs Chinese medicinal components: Rhizoma Cyperi, Radix Paeoniae Rubra, the Fructus Aurantii of step one gained, step 2 gained old Skin, Flos Chrysanthemi, Radix Scutellariae, Radix Glycyrrhizae Preparata, Fructus Crataegi, the Radix Linderae, Fructus Gardeniae and Fructus Toosendan are dried in 65 DEG C of baking ovens, super Crushing of Ultrafine crosses 100 mesh sieves, and the medicated powder stirred is stand-by;
Step 5, uniformly mixes the extract of step 3 with the medicated powder of step 4, and lyophilization obtains lyophilized powder, Stand-by;
Step 6, weighs L-Trp and vitamin B12
Step 7, uniformly mixes the lyophilized powder of step 5 with each component of step 6, obtains feed additive.
4. a kind of reduction pig as claimed in claim 3 mixes the aggressive feed additive of group, it is characterised in that: Parched with bran method used by step one stir-baked Fructus Aurantii in bran is: the Fructus Aurantii after cutting puts into smoked therewith in pot stir-fry to Fructus Aurantii surface In buff, the sieve that takes the dish out of the pot removes Testa Tritici, cools stand-by.
5. a kind of reduction pig as claimed in claim 3 mixes the aggressive feed additive of group, it is characterised in that: Vinegar-fried method used by the vinegar-fried Pericarpium Citri Reticulatae of step 2 is: Pericarpium Citri Reticulatae vinegar is soaked 10min ± 2min, places in hot pot Fried dry, cools stand-by.
6. a kind of reduction pig as claimed in claim 3 mixes the aggressive feed additive of group, it is characterised in that: Step 3 extractant condition is: extracting pressure 35MPa, extraction temperature 45 DEG C, extraction time 2h, CO2 Flow 8L/h.
CN201610216533.2A 2016-04-08 2016-04-08 Feed additive capable of reducing aggressivity of mixed groups of pigs and preparation method of feed additive Pending CN105795145A (en)

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