CN105794815B - A kind of bactericidal composition and its application containing isopyrazam and thiophanate-methyl - Google Patents
A kind of bactericidal composition and its application containing isopyrazam and thiophanate-methyl Download PDFInfo
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- CN105794815B CN105794815B CN201610266939.1A CN201610266939A CN105794815B CN 105794815 B CN105794815 B CN 105794815B CN 201610266939 A CN201610266939 A CN 201610266939A CN 105794815 B CN105794815 B CN 105794815B
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- Prior art keywords
- thiophanate
- methyl
- isopyrazam
- bactericidal composition
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- 239000005799 Isopyrazam Substances 0.000 title claims abstract description 68
- XTDZGXBTXBEZDN-UHFFFAOYSA-N 3-(difluoromethyl)-N-(9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-1-methylpyrazole-4-carboxamide Chemical compound CC(C)C1C2CCC1C1=C2C=CC=C1NC(=O)C1=CN(C)N=C1C(F)F XTDZGXBTXBEZDN-UHFFFAOYSA-N 0.000 title claims abstract description 66
- 239000005842 Thiophanate-methyl Substances 0.000 title claims abstract description 56
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 20
- 230000002265 prevention Effects 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 10
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000000375 suspending agent Substances 0.000 claims description 8
- 239000006185 dispersion Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000575 pesticide Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 241000223218 Fusarium Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 241000209140 Triticum Species 0.000 abstract description 14
- 235000021307 Triticum Nutrition 0.000 abstract description 14
- 208000031888 Mycoses Diseases 0.000 abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 206010039509 Scab Diseases 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 7
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 235000013339 cereals Nutrition 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 230000003111 delayed effect Effects 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 27
- 238000000034 method Methods 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 14
- 239000003921 oil Substances 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 229920000056 polyoxyethylene ether Polymers 0.000 description 11
- 229940051841 polyoxyethylene ether Drugs 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 description 10
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 239000004530 micro-emulsion Substances 0.000 description 9
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 239000004563 wettable powder Substances 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- -1 amido benzene sulfonic acid sodium salt Chemical compound 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- YFNCATAIYKQPOO-UHFFFAOYSA-N thiophanate Chemical compound CCOC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OCC YFNCATAIYKQPOO-UHFFFAOYSA-N 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 244000299507 Gossypium hirsutum Species 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 241000223195 Fusarium graminearum Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 150000003851 azoles Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- BVTGSQDXCBEQQI-UHFFFAOYSA-N naphthalene;1h-pyrazole Chemical compound C=1C=NNC=1.C1=CC=CC2=CC=CC=C21 BVTGSQDXCBEQQI-UHFFFAOYSA-N 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing isopyrazam and thiophanate-methyl and its applications.The bactericidal composition is using isopyrazam and thiophanate-methyl as principle active component, and wherein the mass ratio of isopyrazam and thiophanate-methyl is 1~70：1~50.The bactericidal composition can be applied to prevention Cereal, fruit tree, vegetable disease, has higher synergistic function, overcomes and delayed the resistance to the action of a drug of germ, and sterilization speed is fast, the lasting period is long, reduces application cost, and control effect is substantially better than the use of its single dose.The present invention can be used for preventing the fungal disease on crops, it is particularly possible to which, for preventing the fungal diseases such as wheat rust, wheat scab, effect is better than single dose use.
Description
Technical field：
The present invention relates to a kind of bactericidal composition and application thereof, it is especially a kind of using isopyrazam and thiophanate-methyl as
The bactericidal composition of main active and its application.
Background technology
Isopyrazam (Isopyrazam), molecular formula：C20H23F2N3O, chemical name：3- difluoromethyl -1- methyl-N-
【1,2,3 ,-tetrahydrochysene=9- (1- Methylethyls)-Isosorbide-5-Nitrae-methanonaphthalen-5- bases】- 1H- pyrazole-4-carboxamides.
Isopyrazam is pyrazoles series bactericidal agent, is the absorbability that a kind of new spectrum, protection and therapeutic activity have concurrently
Fungicide.
Thiophanate-methyl (Thiophanate-methyl), molecular formula：C12H14N4O4S2, chemical name：1,2- bis--(3-
Methoxycarbonyl group -2- ghiourea groups) benzene.Structural formula：
Thiophanate-methyl is wide spectrum systemic fungicide, can prevent Cereal, cotton, water fruits and vegetables turf and other crops
Various diseases, such as wheat, barley and highland barley head blight, disease in cotton seedling stage, wheat rust, fruit diseases etc..
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with the change of pattern of farming, melon fruits and vegetables etc.
Industrial crops cultivated area progressively expands, and disease occurrence degree, generation quantity increase, and difficulty increases in prevention；Separately
On the one hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the control effect of single dose is had a greatly reduced quality, plant
Disease control is faced with significant challenge.
The content of the invention：
The purpose of the present invention is be directed to above-mentioned technical problem provide a kind of applied widely, at low cost, effect it is good containing pyrrole
The plant bactericidal composition of azoles naphthalene bacterium amine and thiophanate-methyl.
Cause answering on fungal disease in prevention plant epiphyte it is a still further object of the present invention to provide the bactericidal composition
With the especially purposes on prevention wheat rust, the fungal diseases such as wheat scab.
The purpose of the present invention is be achieved through the following technical solutions：
A kind of bactericidal composition containing isopyrazam and thiophanate-methyl, the bactericidal composition is with isopyrazam and first
Base thiophanate is principle active component, and wherein the mass ratio of isopyrazam and thiophanate-methyl is 1~70：1~50, wherein killing
Effective ingredient is present in enhancing effective amount in composition in bacteria composition.
The mass ratio of the bactericidal composition, wherein isopyrazam and thiophanate-methyl is preferably 1~20：1~30,
Further preferably 1~10：1~20, it is still more preferably 1~5：1~6.
Isopyrazam and the preferred mass of thiophanate-methyl proportioning or：70：1、50：1、30：1、20：1、10：
1、5：1、2.5：1、1：1、1：2、1：4、1：6、1：10、1：20、1：30、1：50.
In the compositions of the present invention, the mass percentage that both isopyrazam and thiophanate-methyl account for composition is 2
~80%.It is preferred that 5~70%.
The bactericidal composition, wherein being helped using isopyrazam and thiophanate-methyl as principle active component with known
Agent and excipient are re-dubbed any one dosage form allowed on pesticide.These known auxiliary agents, excipients have dispersant, diffusion
Agent, antifoaming agent, wetting agent, disintegrant etc. may be employed calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene ether, benzylphenol and gather
Ethylene oxide ether, phenethyl phenol polyethenoxy ether, fatty alcohol polyoxyethylene ether and its similar products, aliphatic amine polyoxyethylene ether, fat
Fat acid ethylene oxide adduct, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, Nonyl pheno
Ether, TWEEN Series, fatty alcohol polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphorous
One or more of hydrochlorate, lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, quaternary etc. combination, figuration
Agent includes cyclohexanone, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propylene glycol), deionized water.More than auxiliary agent, excipient
And other auxiliary materials can be applied alone or be used in combination.
The bactericidal composition, dosage form are missible oil, wettable powder, suspending agent, aqueous emulsion or water dispersion granule.
Application of the above-mentioned bactericidal composition on prevention fungal diseases of plants drug is prepared.Especially in prevention cereal
Application in terms of class, fruit tree, vegetable crop disease has remarkable result.
Above-mentioned application, the fungal diseases of plants are at least one of wheat rust, wheat scab.
The characteristics of bactericidal composition of the present invention：
1st, the isopyrazam and thiophanate-methyl used in the present invention, the mechanism of action is different, and mutual mixture will not generate low
It touches, can be synergistic, dosage is reduced, reduces cost.
2nd, the present composition scope of application increase, suitable for prevention Cereal, fruit tree, vegetables refractory fungal disease,
Particularly preventing wheat rust, wheat scab etc. has significant effect.Bactericidal composition of the present invention is to sac fungus, load
Bacterium, Fungi Imperfecti and Oomycete fungal disease have good control effect；And inhibit pest or fungi to unitary agent (pyrazole naphthalene
Bacterium amine and thiophanate-methyl are any) drug-fast generation.Bactericidal composition of the present invention can generate higher synergistic function,
And the dosage of the amount ratio independent reactive compound of the mixture substantially reduces, i.e., the activity of mixture is more than independent component
Activity.
Beneficial effects of the present invention compared with prior art：(1) compared with single dose, said composition antagonism fungal disease is such as
The fungal diseases such as powdery mildew of cucumber, wheat rust, wheat scab have apparent synergistic function, overcome and have delayed anti-medicine
Property, expand prevention spectrum, hence it is evident that improve control effect；(2) prevention recruitment, drug cost are reduced；(3) alternative routine and easily production
The pesticide of raw resistance；(4) compared with single dose, production and application cost reduces；(5) the drug-fast generation of fungi, effect are inhibited
It is used apparently higher than its single dose.
Specific embodiment
The invention will be further described with reference to embodiments, and the preparation method of dosage form is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Indoor biometrics are tested：
Indoors using mycelial growth rate method, EC of the different agents to bacterial strain is measured50Value, using co-toxicity coefficient calculating side
Method calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, circular is as follows：
EC (is generally selected as standard agent using a certain single dose in mixture50Junior), it is calculated：
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
The toxicity index of the toxicity index of theoretical toxicity index=A single doses × A single doses proportion+B single doses in mixture
× B single doses proportion in mixture
Survey the EC of toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：Mixture has synergetic when CTC is more than 120, and CTC exists when being less than 80 for antagonism, CTC
It is summation action between 80-120.
According to active ingredient isopyrazam (A)：Thiophanate-methyl (B) quality proportioning is：80：1、70：1、50：1、30：
1、20：1、10：1、5：1、2.5：1、1：1、1：2、1：4、1：6、1：10、1：20、1：30、1：50、1：60 are tested, and measure it
To the co-toxicity coefficient of fusarium graminearum (FusaHum graminearum Sehw.).
Table 1：Isopyrazam+thiophanate-methyl different ratio is to the indoor biometrics result of wheat scab
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 13.16% isopyrazam EC | Y=2.939+2.598X | 6.215 | - |
| 70% thiophanate-methyl WP | Y=2.743+3.620X | 4.201 | - |
| A:B=80:1 | Y=2.887+2.358X | 7.873 | 78.48 |
| A:B=70:1 | Y=4.126+1.526X | 3.741 | 165.02 |
| A:B=50:1 | Y=4.316+0.987X | 4.934 | 124.78 |
| A:B=30:1 | Y=3.640+2.056X | 4.584 | 133.52 |
| A:B=20:1 | Y=3.280+3.112X | 3.571 | 170.18 |
| A:B=10:1 | Y=3.557+2.598X | 3.592 | 165.82 |
| A:B=5:1 | Y=3.372+3.201X | 3.225 | 178.45 |
| A:B=2.5:1 | Y=3.875+2.563X | 2.747 | 199.01 |
| A:B=1:1 | Y=3.844+2.635X | 2.747 | 182.45 |
| A:B=1:2 | Y=3.779+3.052X | 2.512 | 187.49 |
| A:B=1:4 | Y=4.320+1.547X | 2.752 | 163.25 |
| A:B=1:6 | Y=4.483+1.252X | 2.588 | 170.18 |
| A:B=1:10 | Y=3.223+3.625X | 3.091 | 140.05 |
| A:B=1:20 | Y=3.263+4.001X | 2.717 | 157.04 |
| A:B=1:30 | Y=3.523+3.687X | 2.516 | 168.72 |
| A:B=1:50 | Y=4.025+2.034X | 3.015 | 140.21 |
| A:B=1:60 | Y=3.655+2.023X | 4.623 | 91.36 |
Field control effectiveness test：
The pesticidal preparations prevention wheat scab disease experiment made from above-described embodiment.
1st, test process：This test medicine dosage sets three concentration for the treatment of, comparison medicine respectively according to the difference of each ingredient
Agent is pesticide single dose 13.16% isopyrazam EC and 70% thiophanate-methyl WP and blank clean water experiment respectively.
2nd, each plot area of test method is 66.7m2, it is repeated 3 times；Investigation drug effect side after investigating and prevent before dispenser
Method is：5 points of grab sample in test process area carry out severity Scaling according to national field trial relevant criterion, calculate preventive effect.
Result of the test is shown in Table 2：
2 field test effect of table
By indoor biometrics and field efficacy, the result shows that, isopyrazam has apparent with thiophanate-methyl composition
Synergistic function, the control effect of composition is excellent, and control effect is better than single dose kind, has application in agricultural is applied
Value.
Two kinds of reactive compounds can be processed into any one dosage form of permission, illustrate two kinds below with specific embodiment
The preparation that active ingredient is processed into, but the preparation that can process of the two kinds of active components be not limited only to it is set forth below.
Embodiment 1：15% isopyrazam thiophanate-methyl wettable powder (1:2)
By isopyrazam 5g, thiophanate-methyl 10g, detergent LS (to methoxyl group aliphatic acid amido benzene sulfonic acid sodium salt) 2g,
Dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin add to 100g mixtures and carry out air-flow crushing, are made
Active ingredient mass percent is 15% isopyrazam thiophanate-methyl wettable powder.
Embodiment 2：15% isopyrazam thiophanate-methyl wettable powder (1:4)
By isopyrazam 3g, thiophanate-methyl 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g,
Kaolin adds to 100g mixtures and carries out air-flow crushing, and it is 15% isopyrazam methyl that active ingredient mass percent, which is made,
Thiophanate wettable powder.
Embodiment 3：14% isopyrazam thiophanate-methyl wettable powder (1:6)
By isopyrazam 2g, thiophanate-methyl 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g,
Kaolin adds to 100g mixtures and carries out air-flow crushing, and it is 14% isopyrazam methyl that active ingredient mass percent, which is made,
Thiophanate wettable powder.
Embodiment 4：20% isopyrazam thiophanate-methyl suspending agent (1:1)
Weigh 10g isopyrazams, 10g thiophanate-methyls, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate
4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g, in sand mill with water
Effective ingredient percent is made under effect as 20% isopyrazam thiophanate-methyl suspending agent.
Embodiment 5：55% isopyrazam thiophanate-methyl aqueous emulsion (1:10)
Weigh 5g isopyrazams, 50g thiophanate-methyls, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g,
Alkylphenol polyoxyethylene ether 1g, solvent naphtha 13g, adds water to 100g.The method that more than raw material is routinely prepared to aqueous emulsion is put into
Mixing kettle high speed mixes, and effective ingredient percent is made as 55% isopyrazam thiophanate-methyl aqueous emulsion.
Embodiment 6：42% isopyrazam methyl sulfur bacterium missible oil (1:20)
Weigh 2g isopyrazams, 40g thiophanate-methyls, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether
5g, solvent naphtha to 100g.More than raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil, active ingredient matter is made
Amount percentage is 42% isopyrazam methyl sulfur bacterium missible oil.
Embodiment 7：70% isopyrazam methyl sulfur bacterium missible oil (2.5:1)
Weigh 50g isopyrazams, 20g thiophanate-methyls, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether
2g, castor oil polyoxyethylene ether 2g, solvent naphtha to 100g.In the method input mixing kettle that more than raw material is routinely prepared to missible oil
Effective ingredient percent is made as 70% isopyrazam methyl sulfur bacterium missible oil in mixing.
Embodiment 8：18% isopyrazam thiophanate-methyl water dispersion granule (5：1)
Weigh 15g isopyrazams, 3g thiophanate-methyls, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate
5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complement to 100g, and more than raw material is formed with imitating by water dispersible granular agent method
Ingredient percent is 17% isopyrazam thiophanate-methyl water dispersion granule.
Embodiment 9：11% isopyrazam methyl sulfur bacterium missible oil (10:1)
Weigh 10g isopyrazams, 1g thiophanate-methyls, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether
7g, solvent naphtha to 100g.More than raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil, active ingredient matter is made
Amount percentage is 11% isopyrazam methyl sulfur bacterium missible oil.
Embodiment 10：31.5% isopyrazam thiophanate-methyl microemulsion (20:1)
Weigh 30g isopyrazams, 1.5g thiophanate-methyls, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyoxyethylene
Ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.By more than raw material routinely
It prepares and is mixed in the method input mixing kettle of microemulsion, effective ingredient percent is made as 31.5% isopyrazam first
Base thiophanate microemulsion.
Embodiment 11：31% isopyrazam methyl sulfur bacterium missible oil (30:1)
Weigh 30g isopyrazams, 1g thiophanate-methyls, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether
4g, solvent naphtha to 100g.More than raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil, active ingredient matter is made
Amount percentage is 31% isopyrazam methyl sulfur bacterium missible oil.
Embodiment 12：51% isopyrazam thiophanate-methyl suspending agent (50:1)
Weigh 50g isopyrazams, 1g thiophanate-methyls, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate
4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g, in sand mill with water
Effective ingredient percent is made under effect as 51% isopyrazam thiophanate-methyl suspending agent.
Embodiment 13：32% isopyrazam thiophanate-methyl microemulsion (1:15)
Weigh 2g isopyrazams, 30g thiophanate-methyls, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether
Phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.More than raw material is routinely matched somebody with somebody
It is mixed in the method input mixing kettle of microemulsion processed, effective ingredient percent is made as 32% isopyrazam methyl sulphur
Bacterium spirit microemulsion.
Embodiment 14：6% isopyrazam thiophanate-methyl aqueous emulsion (1:5)
Weigh 1g isopyrazams, 5g thiophanate-methyls, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkane
Base phenol polyethenoxy ether 1g, solvent naphtha 13g add water to 100g.The method input that more than raw material is routinely prepared to aqueous emulsion is mixed
The mixing of kettle high speed is closed, effective ingredient percent is made as 6% isopyrazam thiophanate-methyl aqueous emulsion.
Embodiment 15：62% isopyrazam thiophanate-methyl microemulsion (1:30)
Weigh 2g isopyrazams, 60g thiophanate-methyls, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether
Phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.More than raw material is routinely matched somebody with somebody
It is mixed in the method input mixing kettle of microemulsion processed, effective ingredient percent is made as 62% isopyrazam methyl sulphur
Bacterium spirit microemulsion.
Embodiment 16：51% isopyrazam thiophanate-methyl suspending agent (1:50)
Weigh 1g isopyrazams, 50g thiophanate-methyls, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate
4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g, in sand mill with water
Effective ingredient percent is made under effect as 51% isopyrazam thiophanate-methyl suspending agent.
Embodiment 17：7% isopyrazam thiophanate-methyl water dispersion granule (1：2.5)
Weigh 2g isopyrazams, 5g thiophanate-methyls, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g,
Polyvinyl alcohol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, and more than raw material is made by water dispersible granular agent method
Active ingredient mass percent is 7% isopyrazam thiophanate-methyl water dispersion granule.
Claims (8)
1. a kind of bactericidal composition containing isopyrazam and thiophanate-methyl answering on prevention gibberella saubinetii medicine is prepared
With, it is characterised in that the bactericidal composition using isopyrazam and thiophanate-methyl as active ingredient, wherein isopyrazam with
The mass ratio of thiophanate-methyl is 1~70：1~50.
2. application according to claim 1, it is characterised in that the mass ratio of the isopyrazam and thiophanate-methyl is 1
~20：1~30.
3. application according to claim 2, it is characterised in that the mass ratio of the isopyrazam and thiophanate-methyl is 1
~10：1~20.
4. application according to claim 3, it is characterised in that the mass ratio of the isopyrazam and thiophanate-methyl is 1
~5：1~6.
5. application according to claim 1, it is characterised in that both the isopyrazam and thiophanate-methyl account for group
The mass percentage for closing object is 2-80%.
6. application according to claim 5, it is characterised in that both the isopyrazam and thiophanate-methyl account for group
The mass percentage for closing object is 5-70%.
7. application according to claim 1, it is characterised in that using isopyrazam and thiophanate-methyl as it is main effectively into
Divide and insecticides adjuvant, excipients are configured to any one dosage form allowed on pesticide.
8. application according to claim 7, it is characterised in that the dosage form is missible oil, suspending agent, aqueous emulsion, wettable
Pulvis or water dispersion granule.
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| CN101677558A (en) * | 2007-04-25 | 2010-03-24 | 先正达参股股份有限公司 | fungicidal compositions |
| EP2366289A1 (en) * | 2010-03-18 | 2011-09-21 | Basf Se | Synergistic fungicidal mixtures |
| CN105230642A (en) * | 2014-07-11 | 2016-01-13 | 深圳诺普信农化股份有限公司 | Bactericidal composition containing isopyrazam and application thereof |
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|---|---|---|---|---|
| CN101677558A (en) * | 2007-04-25 | 2010-03-24 | 先正达参股股份有限公司 | fungicidal compositions |
| EP2366289A1 (en) * | 2010-03-18 | 2011-09-21 | Basf Se | Synergistic fungicidal mixtures |
| CN105230642A (en) * | 2014-07-11 | 2016-01-13 | 深圳诺普信农化股份有限公司 | Bactericidal composition containing isopyrazam and application thereof |
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