CN105770281A - 一种中西药结合治疗胆石症的组合药物 - Google Patents
一种中西药结合治疗胆石症的组合药物 Download PDFInfo
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Abstract
本发明涉及一种中西药结合治疗胆石症的组合药物，其包括中药组分和西药组分，其中，中药组分为：金钱草7～17g、川芎7～17g、枳实1～11g、大腹皮1～11g、薄雪火绒草4～14g、秦艽7～17g、翻白柴7～17g、青嵩1～11g、金铃子11～21g；西药组分为：熊去氧胆酸5～15g、冰醋酸1～11g。本发明由中西医结合配制，疗效稳定、标本兼治，西药组分中熊去氧胆酸、冰醋酸可针对胆石症做出快速的应对，快速解表缓解症状，中药组分方中诸药配伍、君臣协力、佐使共辅，旨在从根本上治疗胆石症为最终目的，同时能够逐步提高人体抗病能力，保护肝脏。
Description
技术领域
本发明涉及一种普外科药物，特别涉及一种中西药结合治疗胆石症的组合药物。
背景技术
胆石症是指胆道系统(包括胆囊和胆管)的任何部位发生结石的疾，主要症状为腹痛(胀痛或绞痛，剧痛)、恶心呕吐，畏寒、发热及黄疸，结石的种类和成分不完全相同，临床表现取决与结石是否引起但到感染、胆道梗阻及梗阻的部位和程度，胆石症是世界范围的常见病，我国也不例外。在自然人群中，胆石症的发病率达10％左右，国内尸检结果报告，胆石症的发生率为7％，女性患者多见，尤其是较肥胖的女性，男女之比约为1：2。对于胆石症目前尚缺少公认安全有效的治疗药物。其原因在于传统中药虽可根除疾病，但是起效缓慢，西药起效较快，但多为针对症状治疗，无法根除疾病，容易复发；而现有中西药物联用因为对选择药物种类的筛选不理想或用量配合妥当，均存在不同程度的药效抵消甚至药效拮抗。
发明内容
本发明要解决的技术问题是如何克服现有技术的上述缺陷，提供一种中西药结合治疗胆石症的组合药物。
为解决上述技术问题，本中西药结合治疗胆石症的组合药物，其特征是：包括中药组分和西药组分，其中，中药组分为：金钱草7～17g、川芎7～17g、枳实1～11g、大腹皮1～11g、薄雪火绒草4～14g、秦艽7～17g、翻白柴7～17g、青嵩1～11g、金铃子11～21g；西药组分为：熊去氧胆酸5～15g、冰醋酸1～11g；所述中药组分的制备方法为，按上述配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外三分之二量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；所述西药组分的制备方法为，按上述配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
作为优选配比范围，所述中药组分为：金钱草11～13g、川芎11～13g、枳实5～7g、大腹皮5～7g、薄雪火绒草8～10g、秦艽11～13g、翻白柴11～13g、青嵩5～7g、金铃子15～17g；所述西药组分为：熊去氧胆酸9～11g、冰醋酸5～7g。
作为优选配比，所述中药组分为：金钱草17g、川芎7g、枳实11g、大腹皮1g、薄雪火绒草14g、秦艽7g、翻白柴17g、青嵩11g、金铃子11g；所述西药组分为：熊去氧胆酸15g、冰醋酸1g。
作为优选配比，所述中药组分为：金钱草7g、川芎17g、枳实1g、大腹皮11g、薄雪火绒草4g、秦艽17g、翻白柴7g、青嵩1g、金铃子21g；所述西药组分为：熊去氧胆酸5g、冰醋酸11g。
作为进一步优选配比，金钱草13g、川芎11g、枳实7g、大腹皮5g、薄雪火绒草10g、秦艽11g、翻白柴13g、青嵩7g、金铃子15g；所述西药组分为：熊去氧胆酸11g、冰醋酸5g。
作为进一步优选配比，金钱草11g、川芎13g、枳实5g、大腹皮7g、薄雪火绒草8g、秦艽13g、翻白柴11g、青嵩5g、金铃子17g；所述西药组分为：熊去氧胆酸9g、冰醋酸7g。
作为优选配方量，金钱草12g、川芎12g、枳实6g、大腹皮6g、薄雪火绒草9g、秦艽12g、翻白柴12g、青嵩6g、金铃子16g；所述西药组分为：熊去氧胆酸10g、冰醋酸6g。
使用方法：
中西药均为早中晚每日三次，中药每次服用量为2g，西药每次服用量为0.5g，西药先服，40分钟后在服用中药
药理分析
金钱草：性微寒，味甘、咸；归肝、胆、肾、膀胱经；清热利湿，通淋，消肿；用于热淋、砂淋、尿涩作痛，黄疸尿赤，痈肿疔疮，毒蛇咬伤，肝胆结石，尿路结石。
川芎：味辛，性温；归肝、胆、心经；活血行气，祛风止痛。
枳实：味苦，性寒；归肝、胆经；泻肝胆实火，除下焦湿热。
大腹皮：味辛，性微温；归脾、胃、大肠、小肠经；归脾、胃经；用于湿阻气滞，脘腹胀闷，大便不爽，水肿胀满，脚气浮肿，小便不利。
薄雪火绒草：味微甘，性平；归膀胱、心、肺经；发汗解肌、温经通络。
秦艽：味辛、苦，性微寒；归胃、肝、胆经；袪风湿、舒筋络、清虚热、清湿热。
翻白柴：味苦、辛，性微寒；归脾、胃、肝、胆经；清利湿热，利胆退黄。
青嵩：味辛、苦，性温；归脾、大肠、三焦经；行气、止痛、健脾、消食，行气止痛、调中导滞。
金铃子：味辛、苦，性温；归心、肝、脾经；调气活血，定通，追毒的功效。
本发明一种中西药结合治疗胆石症的组合药物由中西医结合配制，疗效稳定、标本兼治，服用方便简单且无毒性副作用，安全可靠，西药组分中熊去氧胆酸、冰醋酸可针对胆石症做出快速的应对，快速解表缓解症状，中药组分以金钱草、川芎、枳实、大腹皮为君药；以薄雪火绒草、秦艽、翻白柴为臣药，以青嵩、金铃子为佐使药配制而成；方中诸药配伍、君臣协力、佐使共辅，旨在从根本上治疗胆石症为最终目的，同时能够逐步提高人体抗病能力，保护肝脏。
具体实施方式
实施例1：按金钱草17g、川芎7g、枳实11g、大腹皮1g、薄雪火绒草14g、秦艽7g、翻白柴17g、青嵩11g、金铃子11g的配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外二分之一量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；
按熊去氧胆酸15g、冰醋酸1g的配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
实施例2：按金钱草7g、川芎17g、枳实1g、大腹皮11g、薄雪火绒草4g、秦艽17g、翻白柴7g、青嵩1g、金铃子21g的配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外二分之一量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；
按熊去氧胆酸5g、冰醋酸11g的配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
实施例3：按金钱草13g、川芎11g、枳实7g、大腹皮5g、薄雪火绒草10g、秦艽11g、翻白柴13g、青嵩7g、金铃子15g的配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外二分之一量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；
按熊去氧胆酸5g、冰醋酸11g的配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
实施例4：按金钱草13g、川芎11g、枳实7g、大腹皮5g、薄雪火绒草10g、秦艽11g、翻白柴13g、青嵩7g、金铃子15g的配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外二分之一量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；
按熊去氧胆酸5g、冰醋酸11g的配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
实施例5：按金钱草13g、川芎11g、枳实7g、大腹皮5g、薄雪火绒草10g、秦艽11g、翻白柴13g、青嵩7g、金铃子15g的配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外二分之一量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；
按熊去氧胆酸5g、冰醋酸11g的配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
其中，实施例5制备的中西药结合治疗胆石症的组合药物汤剂E临床应用效果最佳，故为实施例5最佳实施例。
临床资料
对600例患者进行治疗观察，以证明本发明的药物对胆石症病患都有独到疗效，
| 胆石症病程 | 病例 | 治愈 | 显效 | 有效 | 无效 | 有效率 |
| 胆石症病程一周内 | 300 | 90 | 200 | 290 | 10 | 96.67％ |
| 胆石症病程一月内 | 300 | 60 | 190 | 250 | 50 | 83.33％ |
全部病例患者临床观察未见任何不良反应。
综上所述，本发明一种中西药结合治疗胆石症的组合药物是有效且安全的药物。
上述实施方式旨在举例说明本发明可为本领域专业技术人员实现或使用，对上述实施方式进行修改对本领域的专业技术人员来说将是显而易见的，故本发明包括但不限于上述实施方式，任何符合本权利要求书或说明书描述，符合与本文所公开的原理和新颖性、创造性特点的方法、工艺、产品，均落入本发明的保护范围之内。
Claims (7)
1.一种中西药结合治疗胆石症的组合药物，其特征是：包括中药组分和西药组分，其中，
中药组分为：金钱草7～17g、川芎7～17g、枳实1～11g、大腹皮1～11g、薄雪火绒草4～14g、秦艽7～17g、翻白柴7～17g、青嵩1～11g、金铃子11～21g；
西药组分为：熊去氧胆酸5～15g、冰醋酸1～11g；
所述中药组分的制备方法为，按上述配方量称取金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴，将二分之一量所取的金钱草、川芎、枳实、大腹皮煎汤，过滤汤汁作稀释剂，另外二分之一量的金钱草、川芎、枳实、大腹皮、薄雪火绒草、秦艽、翻白柴与其余组分混合，加入混合物30倍量的汤汁浸泡煎煮两次，每次半小时左右，合并两次的煎液过滤，并浓缩至膏状，在60～80℃条件下烘干，粉碎成细粉，用80％的乙醇做粘合剂制成20目颗粒，整粒后加入颗粒质量的1％的硬脂酸镁，干燥后磨粉制成粉末；
所述西药组分的制备方法为，按上述配方量称取熊去氧胆酸、冰醋酸，将二者混合后按常规湿法制粒压片方法制成片剂。
2.根据权利要求1所述的中西药结合治疗胆石症的组合药物，其特征是：所述中药组分为：金钱草11～13g、川芎11～13g、枳实5～7g、大腹皮5～7g、薄雪火绒草8～10g、秦艽11～13g、翻白柴11～13g、青嵩5～7g、金铃子15～17g；所述西药组分为：熊去氧胆酸9～11g、冰醋酸5～7g。
3.根据权利要求1所述的中西药结合治疗胆石症的组合药物，其特征是：所述中药组分为：金钱草17g、川芎7g、枳实11g、大腹皮1g、薄雪火绒草14g、秦艽7g、翻白柴17g、青嵩11g、金铃子11g；所述西药组分为：熊去氧胆酸15g、冰醋酸1g。
4.根据权利要求1所述的中西药结合治疗胆石症的组合药物，其特征是：所述中药组分为：金钱草7g、川芎17g、枳实1g、大腹皮11g、薄雪火绒草4g、秦艽17g、翻白柴7g、青嵩1g、金铃子21g；所述西药组分为：熊去氧胆酸5g、冰醋酸11g。
5.根据权利要求2所述的中西药结合治疗胆石症的组合药物，其特征是：所述中药组分为：金钱草13g、川芎11g、枳实7g、大腹皮5g、薄雪火绒草10g、秦艽11g、翻白柴13g、青嵩7g、金铃子15g；所述西药组分为：熊去氧胆酸11g、冰醋酸5g。
6.根据权利要求2所述的中西药结合治疗胆石症的组合药物，其特征是：所述中药组分为：金钱草11g、川芎13g、枳实5g、大腹皮7g、薄雪火绒草8g、秦艽13g、翻白柴11g、青嵩5g、金铃子17g；所述西药组分为：熊去氧胆酸9g、冰醋酸7g。
7.根据权利要求2所述的中西药结合治疗胆石症的组合药物，其特征是：所述中药组分为：金钱草12g、川芎12g、枳实6g、大腹皮6g、薄雪火绒草9g、秦艽12g、翻白柴12g、青嵩6g、金铃子16g；所述西药组分为：熊去氧胆酸10g、冰醋酸6g。
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