CN105727104A - Medicine composition with effects of diminishing inflammation and relieving cough and method for preparing medicine composition - Google Patents
Medicine composition with effects of diminishing inflammation and relieving cough and method for preparing medicine composition Download PDFInfo
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- CN105727104A CN105727104A CN201610135695.3A CN201610135695A CN105727104A CN 105727104 A CN105727104 A CN 105727104A CN 201610135695 A CN201610135695 A CN 201610135695A CN 105727104 A CN105727104 A CN 105727104A
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- acid
- medicine composition
- pharmaceutical composition
- resin
- extraction
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Links
- 206010011224 Cough Diseases 0.000 title claims abstract description 26
- 239000000203 mixture Substances 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 13
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 9
- 239000003814 drug Substances 0.000 title abstract description 31
- 230000000694 effects Effects 0.000 title abstract description 15
- 230000003467 diminishing effect Effects 0.000 title abstract 2
- 230000004054 inflammatory process Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 95
- 239000000284 extract Substances 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 18
- 239000003960 organic solvent Substances 0.000 claims abstract description 11
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- 239000011347 resin Substances 0.000 claims description 46
- 229920005989 resin Polymers 0.000 claims description 46
- 238000000605 extraction Methods 0.000 claims description 42
- 239000000706 filtrate Substances 0.000 claims description 31
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 30
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 26
- 239000003480 eluent Substances 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 239000012567 medical material Substances 0.000 claims description 19
- 239000003513 alkali Substances 0.000 claims description 18
- 238000010828 elution Methods 0.000 claims description 16
- 239000006210 lotion Substances 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 15
- 235000012907 honey Nutrition 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 15
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 14
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 14
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 12
- 150000001450 anions Chemical class 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000004821 distillation Methods 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 125000002091 cationic group Chemical group 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 9
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 8
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 8
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 8
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 8
- 235000011477 liquorice Nutrition 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- 235000017550 sodium carbonate Nutrition 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 239000003957 anion exchange resin Substances 0.000 claims description 6
- 239000003729 cation exchange resin Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 229940023913 cation exchange resins Drugs 0.000 claims description 4
- 238000002481 ethanol extraction Methods 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 239000001530 fumaric acid Substances 0.000 claims description 4
- 235000011087 fumaric acid Nutrition 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 238000000638 solvent extraction Methods 0.000 claims description 4
- 150000003440 styrenes Chemical class 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- PFRGGOIBYLYVKM-UHFFFAOYSA-N 15alpha-hydroxylup-20(29)-en-3-one Natural products CC(=C)C1CCC2(C)CC(O)C3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C12 PFRGGOIBYLYVKM-UHFFFAOYSA-N 0.000 claims description 3
- SOKRNBGSNZXYIO-UHFFFAOYSA-N Resinone Natural products CC(=C)C1CCC2(C)C(O)CC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C12 SOKRNBGSNZXYIO-UHFFFAOYSA-N 0.000 claims description 3
- 239000002026 chloroform extract Substances 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- HBGPNLPABVUVKZ-POTXQNELSA-N (1r,3as,4s,5ar,5br,7r,7ar,11ar,11br,13as,13br)-4,7-dihydroxy-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1h-cyclopenta[a]chrysen-9-one Chemical compound C([C@@]12C)CC(=O)C(C)(C)[C@@H]1[C@H](O)C[C@]([C@]1(C)C[C@@H]3O)(C)[C@@H]2CC[C@H]1[C@@H]1[C@]3(C)CC[C@H]1C(=C)C HBGPNLPABVUVKZ-POTXQNELSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 2
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- 235000014655 lactic acid Nutrition 0.000 claims description 2
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- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 2
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- 239000002524 monosodium citrate Substances 0.000 claims description 2
- 235000011007 phosphoric acid Nutrition 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- 239000001508 potassium citrate Substances 0.000 claims description 2
- 229960002635 potassium citrate Drugs 0.000 claims description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- 235000011082 potassium citrates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N sec-butylidene Natural products CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 235000011083 sodium citrates Nutrition 0.000 claims description 2
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- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The invention relates to a medicine composition with effects of diminishing inflammation and relieving cough and a method for preparing the medicine composition. The medicine composition comprises, by weight, exocarpium citri grandis, radix stemonae, poria, rhizoma pinelliae, rhizoma cynanchi stauntonii, radix glycyrrhizae, semen armeniacae amarum and fructus schisandrae chinensis. The method for preparing the medicine composition includes distilling the exocarpium citri grandis and the semen armeniacae amarum by the aid of steam; extracting the radix glycyrrhizae and the rhizoma pinelliae by the aid of ethyl alcohol and then extracting the radix glycyrrhizae and the rhizoma pinelliae by the aid of organic solvents; extracting the honey-processed radix stemonae, the honey-processed poria, the honey-processed rhizoma cynanchi stauntonii and the honey-processed fructus schisandrae chinensis by the aid of water; combining extract to obtain the medicine composition. The medicine composition and the method have the advantages that effects of regulating qi-flowing for eliminating phlegm and moistening lungs for relieving the cough can be realized by the medicine composition, and the medicine composition is applicable to the cough, asthma and excessive phlegm due to turbid phlegm obstructing lungs; as observed clinically, definite curative effects are realized by the medicine composition for common cold, bronchitis and faucitis, and toxic and side effects are unfound.
Description
Technical field
The present invention relates to tcm field, be specifically related to pharmaceutical composition of a kind of inflammation-diminishing and cough-controlling and preparation method thereof.
Background technology
Expectorant is turbid stays in lung, and be jammed air flue, clinical with cough with asthma, uncomfortable in chest, abundant expectoration rale be main manifestations card.Be common in cough, breathe heavily, roar, pulmonary distension, lung abscess, and the disease such as the bronchitis of doctor trained in Western medicine, pneumonia.The origin cause of formation of turbid phlegm obstructing in the lung has inside and outside two kinds: endogenous cause of ill is relevant with spleen, as excessive in eating and drinking without temperance, overstrain impairing the spleen, or seven emotions, insufficiency of the spleen mistake all can be made to transport, it is impossible to ascending the clear and descending the turbid, stop gathering with bringing about the spread of body fluid, become expectorant turbid, upper general in lung, therefore have saying of " spleen being the source rising expectorant, the lung being the utensil for storing phlegm ".Exopathogenic factor is then violated lung by wind, heat, the pathogen such as dry, or wind and cold enters inner heat-transformation, and bright liquid becomes expectorant, forms expectorant heat and stops up and hinder in lung；Or the heresy of affection of exogenous wind-cold, send out in priming phlegm retention, become obstruction of the lung by cold-phlegm.
Juhong Tanke liquid is 2010 editions first disclosed compound recipes of the Pharmacopoeia of the People's Republic of China, the preparation method disclosing prescription composition and tablet, capsule.Disclosed extracting method is as follows:
Exocarpium Citri Grandis, the Radix Stemonae, Poria, the Rhizoma Pinelliae, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis etc. eight taste, Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate 80ml, the Six-elements such as medicinal residues and all the other Radixs Stemonae, boiling secondary, each 2 hours, collecting decoction, filter, it is the clear paste of 1.25-1.35 that filtrate is concentrated into relative density when 80 DEG C, adding ethanol makes alcohol content be 75%-80%, stand 24 hours, take supernatant, reclaim ethanol and to be concentrated into relative density when 80 DEG C be the clear paste of 1.18-1.20, with sucrose 400g, Mel 100g, sodium benzoate 3g, ethyl hydroxybenzoate 0.3g, it is stirred to dissolve, add above-mentioned distillate, mixing, filter, let cool, add essence and Mentholum is appropriate, add water to 1000ml, stir evenly, obtain.
Owing to the character of Chinese crude drug active component is different, as adopted said method first Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, medicinal residues the whole water extract-alcohol precipitation of all the other medical materials, last united extraction liquid makes oral liquid, owing to effective ingredient is without extracting completely, in use medicine fails to play whole effect, thus affecting drug effect.
Accordingly, it is desirable to provide a kind of active component extraction ratio that can improve medicine, with the preparation method improving pharmaceutical effectiveness.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for inflammation-diminishing and cough-controlling.
The preparation method that it is an object of the invention to provide a kind of pharmaceutical composition for inflammation-diminishing and cough-controlling.
Pharmaceutical composition for inflammation-diminishing and cough-controlling provided by the invention is made up of the composition of following weight portion: Exocarpium Citri Grandis 300 parts, the processed with honey Radix Stemonae 30 parts, 30 parts of Poria, Rhizoma Pinelliae Preparata 30 parts, Rhizoma Cynanchi Stauntonii 50 parts, 10 parts of Radix Glycyrrhizae, Semen Armeniacae Amarum 100 parts, Fructus Schisandrae Chinensis 20 parts, it is characterized in that, this pharmaceutical composition is prepared from by following methods:
1) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add ethanol extraction, extracting solution crosses neutral alumina, collects effluent, and effluent crosses cationic resin, wash post with water, discard water lotion, use 40%-90% ethanol elution, collecting eluent, resin anion (R.A.) crossed by eluent, washes post with water, discard water lotion, use 40%-90% ethanol elution, collect eluent, concentration, obtains extract A；
2) extracting liquorice, the Rhizoma Pinelliae add ethanol extraction, and extracting solution filters, and filtrate adds the mixing of 3-10% alkali liquor, stands, and filters, discarding precipitation, filtrate adds organic solvent extraction, collects aqueous alkali layer, and pH to 3-4 is adjusted in acid to add 2%, add organic solvent extraction, collect organic solvent layer, reclaim organic solvent, obtain extract B；
3) taking the processed with honey Radix Stemonae, after Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis soak, boil extraction, extracting solution filters, and filtrate concentrates, and obtains extract C；
4) united extraction thing A, B, C, dry, to obtain final product.
Preferably, described step 1) in alkali liquor be: in sodium hydroxide, potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, sodium citrate, potassium citrate, sodium sesquicarbonate, sodium dihydrogen citrate one or more.
Preferably, described step 1) in acid be: in citric acid, lactic acid, phosphoric acid, tartaric acid, malic acid, metatartaric acid, acetic acid, hydrochloric acid, adipic acid, fumaric acid one or more.
Preferably, described step 1) cationic resin is: in 732 strongly acidic styrene type cation exchange resins, 734 strongly acidic styrene type cation exchange resins, D254 macroporous strong basic quaternary ammonium cation exchanger resin, D-61 large hole strong acid styrene system cation exchange resin one or more.
Preferably, described step 1) in resin anion (R.A.) be: in 717 strong-basicity styrene series anion exchange resins, 711 strong-basicity styrene series I type anion exchange resin, D311 macroporous acrylic system weak basic anion exchange resin, D318 macroporous acrylic system weak acid anion exchanger resin one or more.
Preferably, described step 2) in organic solvent be: in ethyl acetate, chloroform, normal butane, dichloromethane or ether one or more.
The preparation method that the invention provides aforementioned pharmaceutical compositions, specifically includes following steps:
1) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add 8-10 times of medical material weight 50%-80% alcohol reflux 1-3 time, each 1-3 hour, united extraction liquid, extracting solution crosses neutral alumina, collect effluent, effluent crosses cationic resin, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 40%-90% ethanol elutions, collect eluent, eluent continued resin anion (R.A.), with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 40%-90% ethanol elutions, collect eluent, being concentrated into relative density when 60-80 DEG C is 1.1-1.2, obtain extract A；
2) extracting liquorice, Rhizoma Pinelliae 40%-90% alcohol heating reflux extract 1-3 time, the every time ethanol of addition medical material weight 6-10 times, each extraction time is 1-3 hour, filtering, merging filtrate, filtrate adds the sodium carbonate that concentration is 3-10%, stand, filter, discard precipitation, filtrate adds chloroform and extracts 3 times, collects aqueous alkali layer, and the hydrochloric acid that aqueous alkali layer adds 2% adjusts pH to 3-4, chloroform extracts, collect chloroform layer, reclaim chloroform, obtain extract B；
3) take the honey Radix Stemonae, Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis added the water soaking of medical material weight 6-10 times after 60 minutes, boiled extraction 1-3 time, and each 1-3 hour, united extraction liquid, filtration, it was 1.1-1.2 that filtrate is concentrated into relative density when 60-80 DEG C, obtains extract C；
4) united extraction thing A, B, C, vacuum drying, to obtain final product.
Present invention also offers the preparation containing aforementioned pharmaceutical compositions, said preparation is separately made by pharmaceutical composition or is made up of pharmaceutical composition and pharmaceutically acceptable carrier.
Present invention also offers the application in the medicine preparing inflammation-diminishing and cough-controlling of aforementioned pharmaceutical compositions or preparation.
Chinese medicine composition of the present invention is detected by inventor, find to use technical solution of the present invention to prepare gained Chinese medicine composition naringin, amygdaloside, glycyrrhizic acid, Rhizoma Pinelliae total acid content significantly high, compared with existing extraction process products obtained therefrom, both have notable difference, and testing result indicates the extraction of some effective ingredient in each component from the side and is better than prior art.Owing to every taste Chinese crude drug all contains many active component, at least not yet there is any a herb purely and simply to be analyzed and know all the components, different Chinese medicine combines when extracting with different extracting modes, due to influencing each other and acting between solvent, temperature and heterogeneity, extremely complex chemical reaction can be produced.Therefore, above-mentioned effective ingredient is a part for Chinese medicine extract active component, and the drug action impact for overall medicine is still not clear.We contrast different extracting mode quality in certain therapeutic use only by effect experiment at present, and the method that there is no changes from the change indicator of part effective ingredient to the curative effect judging compound Chinese patent medicine.Therefore, we observe, by actual animal pharmacodynamics test, the change that drug effect occurs after process reform, and the results show, sample prepared by technical solution of the present invention is really better than prior art and prepares sample.
One provided by the invention is treated colpitic pharmaceutical composition and is had the advantage that
1, the embodiment sample naringin prepared by technical solution of the present invention, amygdaloside, glycyrrhizic acid, Rhizoma Pinelliae total acid content are all remarkably higher than comparative example, experimental result prompting adopts naringin, amygdaloside, glycyrrhizic acid, Rhizoma Pinelliae total acid in the technology of the present invention extraction gained Chinese medicine composition compared with prior art, to extract more complete.
2, results of pharmacodynamic test shows: the embodiment sample prepared by technical solution of the present invention can extend mouse cough incubation period, reduces cough number of times in 3min, points out extractive technique scheme of the present invention to be better than prior art, it is possible to significantly improve the curative effect effect of antitussive.
3, not finding untoward reaction in clinical trial, safety detection, efficacy test do not find and test relevant new abnormal case.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
If no special instructions, the concentration of alcohol in the present invention is percent by volume.
Embodiment 1: scheme one is extracted
1) raw material is weighed by following deal: Exocarpium Citri Grandis 3kg, processed with honey Radix Stemonae 0.3kg, Poria 0.3kg, Rhizoma Pinelliae Preparata 0.3kg, Rhizoma Cynanchi Stauntonii 0.5kg, Radix Glycyrrhizae 0.1kg, Semen Armeniacae Amarum 1kg, Fructus Schisandrae Chinensis 0.2kg.
2) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add 10 times of medical material weight 50% alcohol reflux 1 time, extract 3 hours, filter, extracting solution crosses neutral alumina, collect effluent, effluent crosses 732 cationic resin, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 40% ethanol elutions, collect eluent, eluent continued 717 resin anion (R.A.)s, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 40% ethanol elutions, collect eluent, being concentrated into relative density when 60 DEG C is 1.1, obtain extract A；
3) extracting liquorice, the Rhizoma Pinelliae 40% alcohol heating reflux extract 1 time, add medical material weight 10 times ethanol, extraction time is 3 hours, filtering, filtrate adds the sodium carbonate that concentration is 3%, stands, filtering, discard precipitation, filtrate adds chloroform and extracts 3 times, collect aqueous alkali layer, the hydrochloric acid that aqueous alkali layer adds 2% adjusts pH to 3.0, and chloroform extracts, and collects chloroform layer, reclaim chloroform, obtain extract B；
4) take the honey Radix Stemonae, Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis added the water soaking of medical material weight 10 times after 60 minutes, boiled extraction 1 time, 3 hours, filtered, and it is 1.1 that filtrate is concentrated into relative density when 60-80 DEG C, obtains extract C；
4) united extraction thing A, B, C, vacuum drying, pulverize, add appropriate starch, carboxymethyl cellulose, microcrystalline Cellulose, granulate, dry, granulate, tabletting, coating, obtain tablet.
Embodiment 2:
1) raw material is weighed by following deal: Exocarpium Citri Grandis 3kg, processed with honey Radix Stemonae 0.3kg, Poria 0.3kg, Rhizoma Pinelliae Preparata 0.3kg, Rhizoma Cynanchi Stauntonii 0.5kg, Radix Glycyrrhizae 0.1kg, Semen Armeniacae Amarum 1kg, Fructus Schisandrae Chinensis 0.2kg.
2) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add 8-10 times of medical material weight 60% alcohol reflux 2 times, each 2 hours, united extraction liquid, extracting solution crosses neutral alumina, collect effluent, effluent crosses 734 cationic resin, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 60% ethanol elutions, collect eluent, eluent continued 711 resin anion (R.A.)s, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 60% ethanol elutions, collect eluent, being concentrated into relative density when 70 DEG C is 1.15, obtain extract A；
3) extracting liquorice, the Rhizoma Pinelliae 60% alcohol heating reflux extract 2 times, add the ethanol of medical material weight 8 times every time, each extraction time is 2 hours, filtering, merging filtrate, filtrate adds the sodium bicarbonate that concentration is 5%, stand, filter, discard precipitation, filtrate adds diethyl ether and extracts 3 times, collects aqueous alkali layer, and the citric acid that aqueous alkali layer adds 2% adjusts pH to 3.5, ether extracts, collect chloroform layer, reclaim chloroform, obtain extract B；
4) take the honey Radix Stemonae, Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis added the water soaking of medical material weight 8 times after 60 minutes, boiled extraction 2 times, each 2 hours, and united extraction liquid filters, and it is 1.15 that filtrate is concentrated into relative density when 70 DEG C, obtains extract C；
5) united extraction thing A, B, C, vacuum drying, pulverize, add appropriate starch, granulate, dry, granulate, encapsulated, obtain capsule.
Embodiment 3:
1) raw material is weighed by following deal: Exocarpium Citri Grandis 3kg, processed with honey Radix Stemonae 0.3kg, Poria 0.3kg, Rhizoma Pinelliae Preparata 0.3kg, Rhizoma Cynanchi Stauntonii 0.5kg, Radix Glycyrrhizae 0.1kg, Semen Armeniacae Amarum 1kg, Fructus Schisandrae Chinensis 0.2kg.
2) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add 8-10 times of medical material weight 75% alcohol reflux 3 times, extract 1 hour every time, united extraction liquid, extracting solution crosses neutral alumina, collect effluent, effluent crosses D254 cationic resin, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 75% ethanol elutions, collect eluent, eluent continued D311 resin anion (R.A.), with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 80% ethanol elutions, collect eluent, being concentrated into relative density when 75 DEG C is 1.2, obtain extract A；
3) extracting liquorice, the Rhizoma Pinelliae 80% alcohol heating reflux extract 3 times, add the ethanol of medical material weight 10 times every time, each extraction time is 1 hour, filtering, merging filtrate, filtrate adds the sodium carbonate that concentration is 8%, stand, filter, discard precipitation, filtrate adds extraction into ethyl acetate 3 times, collects aqueous alkali layer, and pH to 3.8 adjusted by the fumaric acid that aqueous alkali layer adds 2%, extraction into ethyl acetate, collect ethyl acetate layer, reclaim ethyl acetate, obtain extract B；
4) take the honey Radix Stemonae, Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis added the water soaking of medical material weight 10 times after 60 minutes, boiled extraction 3 times, each 1 hour, and united extraction liquid filters, and it is 1.2 that filtrate is concentrated into relative density when 75 DEG C, obtains extract C；
5) united extraction thing A, B, C, vacuum drying, pulverize, add appropriate starch, granulate, dry, granulate, subpackage, obtain granule.
Embodiment 4:
1) raw material is weighed by following deal: Exocarpium Citri Grandis 3kg, processed with honey Radix Stemonae 0.3kg, Poria 0.3kg, Rhizoma Pinelliae Preparata 0.3kg, Rhizoma Cynanchi Stauntonii 0.5kg, Radix Glycyrrhizae 0.1kg, Semen Armeniacae Amarum 1kg, Fructus Schisandrae Chinensis 0.2kg.
2) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add 10 times of medical material weight 90% alcohol reflux 3 times, extract 1 hour every time, united extraction liquid, extracting solution crosses neutral alumina, collect effluent, effluent crosses D-61 cationic resin, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 95% ethanol elutions, collect eluent, eluent continued D318 resin anion (R.A.), with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 90% ethanol elutions, collect eluent, being concentrated into relative density when 80 DEG C is 1.2, obtain extract A；
3) extracting liquorice, the Rhizoma Pinelliae 90% alcohol heating reflux extract 3 times, add the ethanol of medical material weight 10 times every time, each extraction time is 1 hour, filtering, merging filtrate, filtrate adds the sodium carbonate that concentration is 10%, stand, filter, discard precipitation, filtrate adds extraction into ethyl acetate 3 times, collects aqueous alkali layer, and pH to 4.0 adjusted by the fumaric acid that aqueous alkali layer adds 2%, extraction into ethyl acetate, collect ethyl acetate layer, reclaim ethyl acetate, obtain extract B；
4) take the honey Radix Stemonae, Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis added the water soaking of medical material weight 10 times after 60 minutes, boiled extraction 3 times, each 1 hour, and united extraction liquid filters, and it is 1.2 that filtrate is concentrated into relative density when 80 DEG C, obtains extract C；
5) united extraction thing A, B, C, mixing, add appropriate sucrose, purified water, potassium sorbate, fill, obtain oral liquid.
Comparative example 1:
Raw material is weighed: Exocarpium Citri Grandis 3kg, processed with honey Radix Stemonae 0.3kg, Poria 0.3kg, Rhizoma Pinelliae Preparata 0.3kg, Rhizoma Cynanchi Stauntonii 0.5kg, Radix Glycyrrhizae 0.1kg, Semen Armeniacae Amarum 1kg, Fructus Schisandrae Chinensis 0.2kg by following deal.
Above eight tastes, Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate 80ml, the Six-elements such as medicinal residues and all the other Radixs Stemonae, boiling secondary, each 2 hours, collecting decoction, filter, it is the clear paste of 1.25-1.35 that filtrate is concentrated into relative density when 80 DEG C, adding ethanol makes alcohol content be 75%-80%, stand 24 hours, take supernatant, reclaim ethanol and to be concentrated into relative density when 80 DEG C be the clear paste of 1.18-1.20, with sucrose 400g, Mel 100g, sodium benzoate 3g, ethyl hydroxybenzoate 0.3g, it is stirred to dissolve, add above-mentioned distillate, mixing, filter, let cool, add essence and Mentholum is appropriate, add water to 1000ml, stir evenly, obtain.
Experimental example 1: the comparison that different preparation method gained sample sizes measure
1 sample packet
Embodiment 4, comparative example 1.
2 contrast projects
Naringin, amygdaloside, glycyrrhizic acid, Rhizoma Pinelliae total acid content.
3 experimental results, in Table 1
The different preparation method gained sample size measurement result of table 1
Table 1 result shows: embodiment of the present invention sample naringin, amygdaloside, glycyrrhizic acid, Rhizoma Pinelliae total acid content are all remarkably higher than comparative example.Experimental result prompting adopts naringin, amygdaloside, glycyrrhizic acid, Rhizoma Pinelliae total acid in the technology of the present invention extraction gained Chinese medicine composition compared with prior art, to extract more complete.
Pharmacodynamics test
Ammonia is caused the impact of mouse cough
1 material
1.1 laboratory animal cleaning grade Male Kunming strain mice 50, weight 18～22g, Guangxi Medical University's animal center provide.Feeding environment: room temperature 20 23 DEG C, relative humidity 45%～6o%, cage tool peracetic acid soln is sterilized, and drinking water is scrubbing water.
1.2 medicines and reagent
Embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1；Ammonia (analytical pure).
2 methods
2.1 packets take Male Kunming strain mice 6O only with administration, are randomly divided into 6 groups, only often organize each 1O, often organize and give following medicine respectively by 0.2ml/10g gastric infusion, every day 1 time, continuous 7d:
Blank group: isometric(al) pure water
Embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1: be all equivalent to crude drug amount 4g/kg, be equivalent to 8 times of adult's quantity.
30min after 2.2 operation last administrations, is placed in each group of mice in inverted 500mL beaker respectively, inside puts a cotton balls, drawing ammonia with 1mL syringe, 0.2mL injects in cotton balls, is inverted rapidly beaker, in order to avoid gas leakage, observe and record cough number of times in mouse cough incubation period and 3min.
3 results are respectively organized cough number of times in mouse cough incubation period and 3min and are compared in Table 1.
Table 1 is respectively organized cough number of times in mouse cough incubation period and 3min and is compared (x ± s)
Note: compare with blank group, * P < 0.05, * * P < 0.01；Compare with comparative example 1 group, #P < 0.05.
From table 1, embodiment 1-4 and 1 group of comparative example compared with blank group, all can extend mouse cough incubation period (P < 0.05, P < 0.01), reduce cough number of times (P < 0.05, P < 0.01) in 3min；But embodiment 1-4 group significance simultaneously is better than comparative example 1 group.Point out extractive technique scheme of the present invention to be better than prior art, the curative effect effect of antitussive can be significantly improved.
4 conclusions
The present invention is Chinese medicine preparation, has activating QI to eliminate phlegm, effect of nourishing the lung to arrest cough, it is adaptable to the cough caused by turbid phlegm obstructing in the lung, asthma, abundant expectoration；Flu, bronchitis, pharyngolaryngitis, by clinical observation determined curative effect, non-invention toxicity, is a kind of new Chinese medicine being worthy to be popularized.And preparation method of the present invention is compared with prior art, curative effect has significant difference.
Although, above use generality explanation, detailed description of the invention and test, the present invention is described in detail, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (8)
1. the pharmaceutical composition of an inflammation-diminishing and cough-controlling, it is made up of the composition of following weight portion: Exocarpium Citri Grandis 300 parts, the processed with honey Radix Stemonae 30 parts, 30 parts of Poria, Rhizoma Pinelliae Preparata 30 parts, Rhizoma Cynanchi Stauntonii 50 parts, 10 parts of Radix Glycyrrhizae, Semen Armeniacae Amarum 100 parts, Fructus Schisandrae Chinensis 20 parts, it is characterized in that, this pharmaceutical composition is prepared from by following methods:
1) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add ethanol extraction, extracting solution crosses neutral alumina, collects effluent, and effluent crosses cationic resin, wash post with water, discard water lotion, use 40%-90% ethanol elution, collecting eluent, resin anion (R.A.) crossed by eluent, washes post with water, discard water lotion, use 40%-90% ethanol elution, collect eluent, concentration, obtains extract A；
2) extracting liquorice, the Rhizoma Pinelliae add ethanol extraction, and extracting solution filters, and filtrate adds the mixing of 3-10% alkali liquor, stands, and filters, discarding precipitation, filtrate adds organic solvent extraction, collects aqueous alkali layer, and pH to 3-4 is adjusted in acid to add 2%, add organic solvent extraction, collect organic solvent layer, reclaim organic solvent, obtain extract B；
3) taking the processed with honey Radix Stemonae, after Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis soak, boil extraction, extracting solution filters, and filtrate concentrates, and obtains extract C；
4) united extraction thing A, B, C, dry, to obtain final product.
2. pharmaceutical composition according to claim 1, it is characterized in that, in described step 1), alkali liquor is: in sodium hydroxide, potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, sodium citrate, potassium citrate, sodium sesquicarbonate, sodium dihydrogen citrate any one or several.
3. pharmaceutical composition according to claim 1, it is characterized in that, in described step 1) acid adding adjust pH, wherein acid is: in citric acid, lactic acid, phosphoric acid, tartaric acid, malic acid, metatartaric acid, acetic acid, hydrochloric acid, adipic acid, fumaric acid any one or several.
4. pharmaceutical composition according to claim 1, it is characterized in that, described step 1) cationic resin is: in 732 strongly acidic styrene type cation exchange resins, 734 strongly acidic styrene type cation exchange resins, D254 macroporous strong basic quaternary ammonium cation exchanger resin, D-61 large hole strong acid styrene system cation exchange resin any one or several.
5. pharmaceutical composition according to claim 1, it is characterized in that, in described step 1), resin anion (R.A.) is: in 717 strong-basicity styrene series anion exchange resins, 711 strong-basicity styrene series I type anion exchange resin, D311 macroporous acrylic system weak basic anion exchange resin, D318 macroporous acrylic system weak acid anion exchanger resin one or more.
6. pharmaceutical composition according to claim 1, it is characterised in that described step 2) in organic solvent be: in ethyl acetate, chloroform, normal butane, dichloromethane or ether any one or several.
7. pharmaceutical composition according to claim 1, it is characterised in that this pharmaceutical composition is prepared from by following steps:
1) Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect distillate, medicinal residues add 8-10 times of medical material weight 50%-80% alcohol reflux 1-3 time, each 1-3 hour, united extraction liquid, extracting solution crosses neutral alumina, collect effluent, effluent crosses cationic resin, with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 40%-90% ethanol elutions, collect eluent, eluent continued resin anion (R.A.), with the washing post of 2 times of weight resins, discard water lotion, continue with 2 times of weight resin 40%-90% ethanol elutions, collect eluent, being concentrated into relative density when 60-80 DEG C is 1.1-1.2, obtain extract A；
2) extracting liquorice, Rhizoma Pinelliae 40%-90% alcohol heating reflux extract 1-3 time, the every time ethanol of addition medical material weight 6-10 times, each extraction time is 1-3 hour, filtering, merging filtrate, filtrate adds the sodium carbonate that concentration is 3-10%, stand, filter, discard precipitation, filtrate adds chloroform and extracts 3 times, collects aqueous alkali layer, and the hydrochloric acid that aqueous alkali layer adds 2% adjusts pH to 3-4, chloroform extracts, collect chloroform layer, reclaim chloroform, obtain extract B；
3) take the honey Radix Stemonae, Poria, Rhizoma Cynanchi Stauntonii, Fructus Schisandrae Chinensis added the water soaking of medical material weight 6-10 times after 60 minutes, boiled extraction 1-3 time, and each 1-3 hour, united extraction liquid, filtration, it was 1.1-1.2 that filtrate is concentrated into relative density when 60-80 DEG C, obtains extract C；
4) united extraction thing A, B, C, vacuum drying, to obtain final product.
8. containing the preparation of pharmaceutical composition described in any one of claim 1-6, it is characterised in that said preparation pharmaceutical composition described in any one of claim 1-6 is separately made or is made up of pharmaceutical composition and pharmaceutically acceptable carrier.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107789556A (en) * | 2016-08-30 | 2018-03-13 | 北京盈科瑞创新医药股份有限公司 | A kind of Juhong Tanke Neulized inhalation pharmaceutical solutions and preparation method thereof |
| WO2023273558A1 (en) * | 2021-06-30 | 2023-01-05 | 广州白云山星群(药业)股份有限公司 | Use of exocarpium citri grandis productive cough extract in preparation of drug for inhibiting human coronavirus infection |
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| CN1559525A (en) * | 2004-02-25 | 2005-01-05 | 江苏康缘药业股份有限公司 | Red tangerine peel medicine for treating sputum cough and its preparation method |
| CN1775274A (en) * | 2005-02-07 | 2006-05-24 | 广东化州中药厂制药有限公司 | Cough-relieving sputum-resolving medicinal composition and preparing method |
| CN101181563A (en) * | 2006-06-16 | 2008-05-21 | 贵州益佰制药股份有限公司 | Chrysoidine productive cough preparations as well as preparation method and mass control method |
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| CN1559525A (en) * | 2004-02-25 | 2005-01-05 | 江苏康缘药业股份有限公司 | Red tangerine peel medicine for treating sputum cough and its preparation method |
| CN1775274A (en) * | 2005-02-07 | 2006-05-24 | 广东化州中药厂制药有限公司 | Cough-relieving sputum-resolving medicinal composition and preparing method |
| CN101181563A (en) * | 2006-06-16 | 2008-05-21 | 贵州益佰制药股份有限公司 | Chrysoidine productive cough preparations as well as preparation method and mass control method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107789556A (en) * | 2016-08-30 | 2018-03-13 | 北京盈科瑞创新医药股份有限公司 | A kind of Juhong Tanke Neulized inhalation pharmaceutical solutions and preparation method thereof |
| WO2023273558A1 (en) * | 2021-06-30 | 2023-01-05 | 广州白云山星群(药业)股份有限公司 | Use of exocarpium citri grandis productive cough extract in preparation of drug for inhibiting human coronavirus infection |
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