CN105726343B - A kind of preparation method for the small water molecule cluster TMW promoting cosmetic active - Google Patents
A kind of preparation method for the small water molecule cluster TMW promoting cosmetic active Download PDFInfo
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- CN105726343B CN105726343B CN201610100851.2A CN201610100851A CN105726343B CN 105726343 B CN105726343 B CN 105726343B CN 201610100851 A CN201610100851 A CN 201610100851A CN 105726343 B CN105726343 B CN 105726343B
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- 230000001737 promoting effect Effects 0.000 title claims abstract description 25
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to the preparation methods of small water molecule cluster TMW for promoting cosmetic active a kind of, and it includes following steps: (1) liquid water freezing being prepared into ice；(2) in a vacuum, using laser splash ice, the plasma comprising small water molecule cluster TMW is generated.The small water molecule cluster TMW activity prepared using method of the present invention is high, can be improved cosmetic active.
Description
Technical field
The present invention relates to cosmetic fields, more particularly it relates to a kind of small water molecule for promoting cosmetic active
The preparation method of cluster TMW.
Background technique
Hydrone contains an oxygen atom and two hydrogen atoms, and there is only intramolecular hydrogen atoms in liquid water and solid water
Covalent bond between oxygen atom, and there are intermolecular interaction, this intermolecular interaction is by a water
The hydrogen bond that the oxygen atom in hydrogen atom and another hydrone in molecule is formed, this intermolecular force are also known as model moral
Hua Li.In liquid water, usually got up with several hydrones by Hydrogenbond；But in solid water, that is, inside ice,
Hydrone is interconnected in a wider context with hydrogen bond, forms the crystal of loose rule.X-ray is studies have shown that ice has four sides
The crystal structure of body, the tetrahedral lattice are that five hydrones are formed by intermolecular hydrogen bonding, and crystals are orderly aligned,
With fixed gap.After ice-out Cheng Shui, the hydrogen bond and regular crystal structure of a large amount of rules are broken, tetrahedron is made
Lattice structure turns to scattered molecular radical, so liquid water ordered arrangement no longer as ice, but form unordered knot
Structure.
Studies have shown that between hydrone by hydrogen bond formed small water molecule cluster after, dissolving power, penetration, metabolism power and
Emulsifying capacity is enhanced, to have certain activation.It can be improved in cosmetics using small water molecule cluster
The activity of cosmetics.Currently, traditional small water molecule cluster (abbreviation of TMW, Tiny Molecular Water) for preparing is adopted more
With electromagnetic method, Mechanical Method, supercritical ultrasonics technology, far infrared collimation method, function ceramics method, information model method etc., these methods are prepared small
Hydrone liveness is low, and these methods are mostly used liquid water to prepare, and generated small water molecule is unordered chaotic structure, not only
The activity of small water molecule itself cannot be improved, can not be used to be promoted the activity of cosmetics.
Therefore it is highly desirable to a kind of method that can prepare high activity and regular small water molecule cluster, makes small water
Molecular cluster is able to ascend the activity of cosmetics.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of small water molecule cluster (TMW) of promotion cosmetic active
Preparation method, the small water molecule cluster (TMW) have very high activity, can be used to be promoted the activity of cosmetics.
One aspect of the present invention is related to a kind of preparation method of small water molecule cluster (TMW) for promoting cosmetic active,
It comprises the steps of:
(1) liquid water freezing is prepared into ice；
(2) under vacuum conditions, it using laser splash ice, generates small water molecule cluster (TMW), the small water molecule cluster
It (TMW) is plasma state.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, liquid water is selected from one or more of following substance: distilled water, deionized water, mineral in the step (1)
Matter water, tap water.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, liquid water is deionized water in the step (1).
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the mineral water includes one or more of following metallic element: iron, potassium, magnesium, aluminium, zinc, silver, sodium,
Titanium.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the vacuum degree of vacuum condition is 2 × 10 in the step (2)-1Pa~8 × 10-3Pa。
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the optical maser wavelength in the step (2) for sputtering is 266nm, 355nm, 532nm, one in 1064nm
Kind.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the optical maser wavelength for sputtering is 1064nm.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the laser energy for sputtering is 10~50mJ.
Another aspect of the present invention relates to a kind of cosmetics, the toiletry bag prepares small containing method of the present invention
Water molecule cluster (TMW).
Another aspect of the present invention relates to a kind of preparation methods of cosmetics comprising the steps of: cosmetics are placed in magnetic
In, under constant stirring, the small water molecule cluster that the preparation method of small water molecule cluster of the present invention (TMW) is obtained
(TMW) it deposits in cosmetics.
In one embodiment, in a kind of preparation method of cosmetics of the present invention, the magnetic induction in the magnetic field
Intensity is 0.003~0.8T, and frequency is 5~50 kHz.
The above-mentioned of the application and other features, aspects and advantages are more readily understood with reference to following detailed description.
Detailed description of the invention
Fig. 1 shows prepare small water molecule cluster (TMW) and contain the schematic diagram of small water molecule cluster (TMW) cosmetics.
The wherein explanation of appended drawing reference:
1- inert gas；2- valve；3- stainless steel pipes；4- quartz glass window；5- laser；6- reaction chamber；7- sample
Slot；8- liquid nitrogen；9- stainless steel pipes；10- blender；11- receiving chamber；The magnetic field 12-.
Specific embodiment
The contents of the present invention can be more easily to understand with reference to the detailed description and embodiment of a specific embodiment of the invention.?
A large amount of terms can be referred in following description and claims, these terms are defined as following meanings.
In present specification and claims, range restriction can be combined and/or be exchanged, if without in addition saying
Bright, these ranges include all subranges contained therebetween.Word "comprising" be not intended to exclude other, additive, component, integer
Or step.Approximate term in specification and claims is used to modify quantity, and it is specific to indicate that the present invention is not limited to this
Quantity further includes the acceptable modified part without will lead to the change of dependency basis this function close with the quantity.?
In certain examples, approximate term likely corresponds to the precision of the instrument of measurement numerical value.
In the present invention, the term " TMW " refers to that the English of small water molecule cluster is explained.
The first aspect of the invention is related to a kind of preparation side of small water molecule cluster (TMW) for promoting cosmetic active
Method, which is characterized in that comprise the steps of:
(1) liquid water freezing is prepared into ice；
(2) under vacuum conditions, it using laser splash ice, generates small water molecule cluster (TMW), the small water molecule cluster
It (TMW) is plasma state.
Liquid water is frozen into ice first.Then, as shown in Figure 1, ice is placed in the sample cell 7 in reaction chamber 6, sample
The liquid nitrogen 8 of slot 7 freezes, and maintains the temperature at -75 DEG C hereinafter, vacuumizing；The upside of reaction chamber 6 is equipped with quartz glass window 4, thoroughly
Optical range can achieve 200nm, so that 5 light beam of laser is irradiated to ice surface by quartz glass window 4, laser splash can generate small
Water molecule cluster (TMW), small water molecule cluster (TMW) is plasmoid, in sputtering process, adjusts and swashs every 10min
Light optical path changes laser spot position.
The sputtering, which refers to, bombards the surface of solids with the particle of certain energy (ion, photon or neutral atom, molecule), makes
The atom or molecule of solid near surface obtain sufficiently large energy and finally escape the surface of solids.Sputtering can only be in certain vacuum
It is carried out under state.
Water is cosmetics and the indispensable substance of skin, using the method for pulsed laser deposition, by height collimation, high-energy
Pulse laser focusing on ice crystal, in ice crystal hydrone absorb pulsed laser energy, generate plasma, plasma
In include cation, the small water molecule cluster and electronics of anion and neutrality；Also, swash when portion of water absorbs pulse
After light energy, Electron absorption energy on the molecular orbit of water forms the small water molecule of excitation state from ground state transition to excitation state
Cluster (TMW).The small water molecule cluster activity that this method generates is higher, and size distribution is uniform.Each hydrone is logical in ice
The ordered arrangement that hydrogen bond forms orientation is crossed, when it is liquid water that ice melts naturally, a large amount of hydrogen bonds are broken, and ice crystal turns to unordered
The liquid water of arrangement, the distance between hydrone change, and fix unlike in ice crystal, certain hydrones can enter
In other lattice.In the present invention, the surface of ice is splashed to using superlaser, directly generation small water molecule cluster etc. from
Daughter, formed small water molecule cluster size are more uniform.
The step of being prepared into ice using liquid water of the present invention, can use well known by persons skilled in the art various
Technology, such as slice ice machine, plate ice machine, tube ice machine, shell ice machine, particle ice maker etc..
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, liquid water is selected from one or more of following substance: distilled water, deionized water, mineral in the step (1)
Matter water, tap water.
The distilled water that the present invention uses meets " Pharmacopoeia of People's Republic of China (2000 editions) " purified water " " standard.For this
Method known to those skilled in the art preparation, such as distillation machine can be used in the distilled water of invention.It can be used for the present invention
Distilled water be also commercially available.
In one embodiment, it is preferable that a kind of small water molecule cluster for promoting cosmetic active of the present invention
(TMW) in preparation method, liquid water is deionized water in the step (1).Deionized water is to remove completely or incompletely
The water of ionic species.Small water molecule cluster (TMW) purity is high formed using deionized water, will not in the plasma of formation
By the adverse effect of other impurities.
It can be commercially available for deionized water of the invention, meet the regulation of International Organization for standardization ISO/TC 147.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the mineral water includes one or more of following metallic element: iron, potassium, magnesium, aluminium, zinc, silver, sodium,
Titanium.
To the advantageous mineral matter element of skin in the mineral water, by high energy pulse laser splash, mineral matter element
It can obtain or lose one and electronically form gaseous mineral ion, and form ion cluster with the hydrone of surrounding, each
Metal ion can combine 1 or more hydrone, wherein partial moisture passes through H atom or oxygen atom and metal center
Coordination forms endothecium structure, and other hydrones are connected by the effect of hydrogen bond and the hydrone of internal layer, forms layer structure.
Mineral matter element micro in this way can be in the form of ionic state close to skin, and passes through electrostatic attraction and hydrone and phosphatide
The affinity interaction of bilayer is by percutaneous absorption.The hydrophilic group of the phospholipid bilayer of cell membrane surface is outside, and has one
The metal ion of fixed charge, water molecule coordination enters cell interior more easily by cell membrane.
It is prepared for mineral water of the invention using technology well known by persons skilled in the art, such as with city tap-water
It for raw water, is processed using sublimate, adds minerals, mineral water is obtained after sterilization processing.Added micro mine
Substance is that cosmetic active can be improved, and strengthens the mineral matter element of skin regeneration function, can be chosen according to cosmetics,
Such as calcium abundant and magnesium have skin of releiving, and increase the effect of elasticity of skin and toughness, silver element has antibacterial and anti-oxidant
The effect of etc..
Waterworks is come from for tap water of the invention, is met " national Drinking Water related sanitary standard ", it is described
The microbiological indicator of tap water, toxicological parameters, sensory properties and general chemical index, radioactive indicator etc. meet national mark
It is quasi-.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the vacuum degree of vacuum condition is 2 × 10 in the step (2)-1Pa~8 × 10-3Pa。
In one embodiment, it is preferable that a kind of small water molecule cluster for promoting cosmetic active of the present invention
(TMW) in preparation method, the vacuum degree of vacuum condition is 2 × 10 in the step (2)-2Pa。
It is commercially available mechanical pump and molecular pump for generating vacuum equipment of the invention.The mechanical pump is mechanically
To by the equipment that pumping container is evacuated and obtains vacuum, it is mechanical to be selected from reciprocating machine pump, stator formula mechanical pump and rotary vane type
One of pump, the attainable ultimate pressure of institute is 1Pa~0.01Pa.The molecular pump is using high-speed rotating rotor dynamic
Amount is transferred to gas molecule, is allowed to obtain directed velocity, to be compressed, to be driven to the one kind taken away for prime after exhaust outlet true
Sky pump, limiting pressure is up to 10-9Pa.It preferably, is turbomolecular pump for molecular pump of the invention.The molecular pump needs to be equipped with
Mechanical pump as fore pump uses.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, the optical maser wavelength in the step (2) for sputtering is 266nm, 355nm, 532nm, one of 1064nm.
It is not particularly limited for laser of the invention, can be gas laser, solid state laser, liquid laser
One of device, semiconductor laser and free electron laser.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, it is preferable that the laser is Nd:YAG laser, and the laser is by operation material, pumping source and resonance
Chamber three parts composition, operation material are mixed with a certain amount of neodymium ion (Nd3+) yttrium-aluminium-garnet (YAG) crystal.The Nd:YAG
The wavelength for the laser that laser can export includes 266nm, 355nm, 1064nm, 532nm；Laser energy is 10~800mJ, light
Beam diameter is 8mm, beam divergence angle < 0.8,1~20ns of pulse width.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, it is further preferred that the optical maser wavelength that Nd:YAG laser used in method of the present invention generates is
1064nm, laser energy are 10~50mJ.
Different material has selectivity to the laser of different wave length and the laser absorption of different-energy, in order to make laser
The water molecule cluster of sputtering has suitable size, and the hydrone for controlling excitation state absorbs the photon energy of specific wavelength,
So that in energy after intermolecular transfer, optimum efficiency is played to cosmetic active is promoted, it need to wavelength, energy to laser
Density is adjusted.On the other hand, human body different tissues also have selectivity to the absorption of the light of different wave length, swash by difference
The cosmetic active of light processing is different, can be also different by the energy of skin histology selective absorbing, is effective solution skin
Problem, promotes skin metabolism, and inventor's discovery finds the obtained cosmetic effect of above-mentioned laser conditions through overtesting
It is splendid.
In one embodiment, a kind of small water molecule cluster (TMW) promoting cosmetic active of the present invention
In preparation method, it is further preferred that the laser energy for sputtering is 20mJ.
In the case where the other parameters such as beam diameter, beam divergence angle, pulse width, optical maser wavelength are constant, according to need
When laser energy being adjusted, the surface of the energy affect laser splash of laser to liquid water and it is internal when, the energy of laser
Metric density and sputter temperature, and the size of the small water molecule cluster that finally generates, cluster institute are electrically charged, cluster institute band energy,
The electronic state of excitation state so the small water molecule cluster of different activities can be generated, and then influences the raising journey to cosmetic active
Degree, the present inventor through experiments, it was found that, when laser energy be 20mJ when, gained small water molecule cluster (TMW) is to cosmetic active
It is best to promote effect.
The second aspect of the present invention is related to a kind of cosmetics, and the toiletry bag prepares small containing method of the present invention
Water molecule cluster (TMW).
The cosmetics can be the cosmetics of various forms well known by persons skilled in the art, include and be not limited to water
Agent, lotion, face cream, eye cream, mildy wash, facial mask, BB frost, consummate liquid, suncream, sun water, acne water, lotion for pimples, face cleaning water,
Face cleaning dew, essential oil, shampoo.The aqua be transparent liquid class cosmetics, include and be not limited to moisture retention water, toner, astringent lotion,
Smoothing toner.The lotion, face cream are liquid frost class cosmetics.The mildy wash, face cleaning water, face cleaning dew refer generally to by oil phase thing,
The liquiform product that the ingredients such as aqueous-phase material, surfactant, moisturizer, nutritional agents are constituted, including but not limited to facial cleanser, face cleaning
Cream, clean skin liquid.The facial mask is a kind of carrier of face beautifying health keeping product, including but not limited to mud paste type, tear-pull, gel-type, wet
Paper handkerchief type facial mask.The BB frost refers to Blemish Balm, and effect includes but is not limited to concealing, adjusts the colour of skin, is sun-proof, careful hair
Hole.The consummate liquid refers to the high nutrient comprising concentration, including but not limited to Essence, essence dew, essence facial mask, essence
The forms such as injection, " Jinghuasu " essence capsule.The suncream is to be added to obstruct or absorb the sun-screening agent of ultraviolet light and prevent to reach
Skin is by the cosmetics of tanned sunburn.The acne water is the liquid treat with acne.The lotion for pimples is tool
There is the liquid for the treatment of acne function.The essential oil is to pass through steam distillation from the flower of plant, leaf, stem, root or fruit
Method, extrusion, cold-maceration or solvent extraction method refine the volatile flavor of extraction.The shampoo is to clean and maintain hair
With the product of skin.
The third aspect of the present invention is related to a kind of preparation method of cosmetics comprising the steps of: cosmetics are placed in magnetic
In, under constant stirring, the small water molecule cluster that the preparation method of small water molecule cluster of the present invention (TMW) is obtained
(TMW) it deposits in cosmetics.
After the deposition refers to that the substance carried by moving medium reaches suitable place, sent out since condition changes
The effect of raw precipitating, the process of accumulation.
As shown in Figure 1, opening the valve 2 on stainless steel pipes 3 after generating small water molecule cluster plasma, passing through
Stainless steel pipes 3 are passed through inert gas 1 into reaction chamber 6, and inert gas 1 has the movement velocity of orientation, and carries small water
Molecular cluster forms plasma molecular beam, and the various particles inside molecular beam do high-speed motion, and intert-gas atoms draw
Enter, the collision that appropriateness occurs inside molecular beam can be made cooling, in front during laser splash, partial moisture is swashed by high-energy
Light 5, which is broken up, becomes isolated atom or atomic group, and atom or atomic group are ionized to as negative ions, and collision is cooling to weigh their
It is newly combined into the small water molecule cluster of high activity, molecular beam is moved along the direction of inert gas, by second stainless steel tube
Road 9 enters in receiving chamber 11, deposits in cosmetics.Receiving chamber is in the magnetic field 12 with some strength, and is used
Blender 10 is stirred continuously cosmetics, cosmetics is mixed with small water molecule cluster using magnetization technology, whole flow process is according to change
Cosmetic dosage is different, and the duration is different.
The inert gas is selected from one of helium, argon gas.
In magnetic field, the molecular motion track of active constituent is constantly twisted in polar water molecules and cosmetics, hydrone
Weaker effect between active ingredient molecule in cosmetics is interrupted, and stronger active force preserves, and is formed by small water molecule
The cosmetic actives molecules that cluster is surrounded.Finally, small water molecule cluster (TMW) is connected to active group contained in cosmetics
Together, this connection includes covalent bond, hydrogen bond, Van der Waals force, electrostatic attraction, is partially in the molecule of excitation state by relaxation mistake
Journey realizes intermolecular energy transmission, so that the effective component contained in cosmetics is in low-lying excitation state, but is wherein in
The molecular moiety of the effective component of low-lying excitation state can have positive charge, can partially have negative electrical charge, and whole cosmetics
Belong to neutral substance, stable state is in cosmetics service life.
The relaxation process refers to that a macroscopic equilibrium system becomes due to the variation of ambient enviroment or by extraneous effect
For nonequilibrium condition, this system is transitioned into the process of new equilibrium state from nonequilibrium condition again.Relaxation process be substantially be
In system microcosmic particle due to interaction positive energy exchange, finally reach the process of Stable distritation.
Skin is divided into epidermis, corium and subcutaneous tissue three parts, epidermis skin play barrier action；Corium is skin
Essence and epidermis complete skin function jointly；Subcutaneous tissue plays supporting role to corium and epidermis.Under normal circumstances, it uses
Cosmetics work just for epidermis, epidermis plays barrier action to skin, and it is cutin respectively that epidermal structure is divided into five layers again
Layer, stratum granulosum, has spinous layer, basal layer at hyaline layer.The water content of keratoderma is in a certain range, and skin just can be smooth, soft
Soft high resilience keeps skin to be in good state, it is considered that and it is in the best state 10% or more, it is easy for doing lower than 10%
It is dry, coarse.Intercellular lipid has apparent bilayer structure, i.e. lipophilic group is inside, and hydrophilic radical is outside, forms water rouge
Alternate interlayer structure, cell membrane are also made of the phospholipid bilayer for being inlaid with protein, and have certain charge.It is this
Structure makes biomembrane have half penetrating and selective permeation property, and the absorption for being conducive to certain small molecule nutriments is seeped
Thoroughly, on the other hand, it combines portion of water and the latter is fixed up, these hydrones are exactly so-called combination water,
It will not be lost in the case where very dry.Moisture of skin is lost, and will lead to dry skin, furfur etc..Lipid barrier
Exception can reduce the moisture preserving function of skin, the growth and differentiation for also directly affecting corneocyte are adjusted, and influence to be good for
Health cuticula is formed.
After the small water molecule cluster (TMW) that method of the present invention is prepared is mixed in magnetic field with cosmetics,
In cosmetics on the one hand bioactive molecule is surrounded by active small water molecule cluster (TMW), the hydrophilic group parent with phospholipid bilayer
It is higher with property and stronger with the electrostatic interaction of the phospholipid bilayer with certain charge, on the other hand also in low-lying excitation
State improves skin to the content of the absorption efficiency of the cosmetic active factor and the combination water of epidermis.
There is no particular limitation for device for generating magnetic field needed for the present invention, can be commercially available magnetic field generator,
It can be the magnetic field by the way that alternating current to be passed through to electromagnetic coil formation.The effect in magnetic field is to make cosmetics and little Shui using magnetic field
Molecular cluster (TMW) mixing.
It is mechanical stirring for stirring means of the invention, used blender is well known by persons skilled in the art stirs
Mix device, such as flat paddle agitator, propeller stirrer, turbine agitator, anchor agitator, squirrel-cage blender, planet
Formula blender etc..
In one embodiment, in a kind of preparation method of cosmetics of the present invention, the magnetic induction in the magnetic field
Intensity is 0.003~0.8T, and frequency is 5~50 kHz.
In one embodiment, it is preferable that, in a kind of preparation method of cosmetics of the present invention, the magnetic field
Magnetic induction intensity be 0.05T, frequency be 20 kHz.
Cosmetics are placed in magnetic field, magnetic field will affect the mobile side of bioactive molecule and small water molecule cluster in cosmetics
To and speed, and influence intermolecular energy transfer process, the activity of the gained cosmetics finally influenced.On the other hand, magnetic field and
Electric field can be converted mutually, and the effect that the cell membrane of bacterium receives strong electric field can generate violent concussion, exceed cell membrane
Plasticity range bacterium can be crushed, so the effect of sterilization can be played.The inventors discovered that the magnetic induction when magnetic field is strong
When degree is 0.05T, when frequency is 20kHz, gained cosmetic active is best.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following embodiment is only used
In the invention will be further described, it should not be understood as limiting the scope of the invention, professional and technical personnel in the field
The some nonessential modifications and adaptations made according to the content of aforementioned present invention, still fall within protection scope of the present invention.
The equipment and sample used:
Mechanical pump: twin-stage high speed direct connection structure piece vacuum pump is bought from Beijing Midwest Co., model 2XZ-4B.
Molecular pump: turbomolecular pump is bought from East and West instrument (Beijing) Technology Co., Ltd., model F-100/110.
Laser: Nd:YAG laser is bought from Han Yu Science and Technology Ltd., model LPY600/700.
Magnetic field generator: purchase exchanges high-intensity magnetic field generating system from Qingdao Zhong Yuhuantai magnetoelectricity Science and Technology Ltd..
Blender: it buys from VELP company of Italy, DLH overhead type stirrer.
Not aqueous cosmetics lotion: choosing the usual ingredients for being used to prepare lotion as follows, by weight: microcrystalline wax 1,
Beeswax 2, lanolin 2, atoleine 20, isotriacontane 10, Span-83 4, polyoxyethylene (20) dehydration mountain
Pears alcohol monoleate 1, propylene glycol 7.Not aqueous emulsion is prepared into using the technology of conventional homogenizer.
Deionized water；Tap water；Mineral water containing following metallic element: iron, potassium, magnesium, aluminium, zinc, silver, sodium, titanium, respectively
0.01μg/ml。
Embodiment 1
Deionized water is prepared into ice using plate ice machine.
In the reaction chamber, 150cm is placed in sample cell3Ice, sample room liquid nitrogen refrigerating maintains the temperature at -75 DEG C
Below.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, is vacuumized, is made in reaction chamber using mechanical pump and molecular pump
Vacuum degree reaches 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water molecule cluster, laser wave produced by laser
A length of 1064nm, laser energy 20mJ；The valve for opening pipeline between gas bomb and reaction chamber, by stainless steel pipes to
It is passed through inert gas in reaction chamber, opens the blender in magnetic field generator and receiving chamber, the magnetic induction intensity in magnetic field is set
0.05T, frequency 20kHz, agitator speed 50rpm, whole flow process continued 1 hour, every 10 minutes adjusting laser positions
Once.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 2
Deionized water is prepared into ice using plate ice machine.In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-1Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 3
Deionized water is prepared into ice using plate ice machine.In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 8 × 10-3Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 4
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 50mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field, frequency 20kHz, agitator speed 50rpm are set, whole flow process continues 0.6
Hour, it is primary every 8 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 5
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 10mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 6
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 355nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 7
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 532nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 8
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.8T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 9
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.003T in magnetic field is set, and frequency 20kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 10
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 50kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 11
Deionized water is prepared into ice using plate ice machine；In the reaction chamber, 150cm is placed in sample cell3Ice, sample
Room liquid nitrogen refrigerating, maintains the temperature at -75 DEG C or less.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, utilizes machinery
Pump and molecular pump vacuumize, and vacuum degree in reaction chamber is made to reach 2 × 10-2Pa.Laser is opened, laser splash is carried out and generates small water
Molecular cluster, optical maser wavelength produced by laser are 1064nm, laser energy 20mJ；It opens between gas bomb and reaction chamber
The valve of pipeline is passed through inert gas into reaction chamber by stainless steel pipes, opens stirring in magnetic field generator and receiving chamber
Device is mixed, the magnetic induction intensity 0.05T in magnetic field is set, and frequency 5kHz, agitator speed 50rpm, it is small that whole flow process continues 1
When, it is primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Embodiment 12
Take the mineral water containing following metallic element: each 0.01 μ g/ml of iron, potassium, magnesium, aluminium, zinc, silver, sodium, titanium；It uses
The mineral water is prepared into ice by plate ice machine.Prepare small water molecule cluster by 1 the method for embodiment, and be free of aquation adornment
The mixing of product lotion.Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine
20, isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7,
Small water molecule cluster (TMW) 53.
Embodiment 13
Tap water is taken, is prepared into ice using plate ice machine, small water molecule cluster is prepared using 1 the method for embodiment, and with
Aqueous cosmetics lotion does not mix.Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin
2, atoleine 20, isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate
1, propylene glycol 7, small water molecule cluster (TMW) 53.
Comparative example 1
The usual ingredients for preparing cosmetic emulsion as follows are chosen, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2,
Atoleine 20, isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1,
Propylene glycol 7, light water 53.Common cosmetic emulsion is prepared into using the technology of conventional homogenizer.
Comparative example 2
Deionized water is prepared into ice using plate ice machine.
In the reaction chamber, 150cm is placed in sample cell3Ice, sample room liquid nitrogen refrigerating maintains the temperature at -75 DEG C
Below.It is put into 100mL not aqueous cosmetics lotion in receiving chamber, reaction chamber is under normal pressure.Laser is opened, laser is carried out
Sputtering generates small water molecule cluster, and optical maser wavelength produced by laser is 1064nm, laser energy 20mJ；Open gas bomb
The valve of pipeline between reaction chamber is passed through inert gas into reaction chamber by stainless steel pipes, open magnetic field generator and
The magnetic induction intensity 0.05T in magnetic field, frequency 20kHz, agitator speed 50rpm is arranged, entirely in blender in receiving chamber
Process continues 1 hour, primary every 10 minutes adjusting laser positions.
Lotion as following formula is finally obtained, in parts by weight: microcrystalline wax 1, beeswax 2, lanolin 2, atoleine 20,
Isotriacontane 10, Span-83 4, polyoxyethylene (20) sorbitan monooleate 1, propylene glycol 7, small water
Molecular cluster (TMW) 53.
Test method
(1) test small water molecule cluster is measured and is added to the anti-reflection coefficient of active constituent in cosmetics with the following method
The efficiency that the cosmetics of small water molecule cluster (TMW) are absorbed by the skin, characterization small water molecule cluster (TMW) are effective to cosmetics
The saturating effect of the rush of active constituent.
Promote substance: small water molecule cluster (TMW)
Model ingredient in cosmetics: isotriacontane
What the Transdermal absorption instrument produced using Tianjin silicon new science and technology Co., Ltd and Aglient company were produced
Agilent1100 high performance liquid chromatograph tests nude mice animal skin.
The nude mice of 10 week old is taken, 20 ± 9g of weight, male, 9, the neck that breaks is put to death, and isolates xiphoid-process lower abdomen skin, carefully
Subcutaneous tissue and fat are rejected, is sandwiched in glass slide after being cleaned with sterile saline, is stored in -20 DEG C -- 30 DEG C of Low-temperature Ice
It is spare in case, because every piece of skin is variant, as far as possible with the skin of abdomen of a nude mice.
Experimental group:, promoting 1 group of substance migration light water, sample sets by 1 group of control group, promotees substance migration institute of the present invention
State the small water molecule cluster (TMW) of method preparation.
Experimental method: taking isolated skin to be fixed among diffusion cell, area 0.825cm2, make stratum corneum side to supply pool,
It is added in supply pool a certain amount of supply solution (being filtered with 0.45um miillpore filter), 5ml acceptable solution is added in acceptance pool, expands
Dissipating pond water bath with thermostatic control water temperature is 36 ± 0.5 DEG C (cell revolving speed: 500r/min), and stirrer is added in diffusion cell, the speed that weighs stirring.
Start timing after sample-adding 15min, respectively at 0h, 1h, 2h, 4h, 6h, 8h, 12h, samples 1ml for 24 hours, and supplement immediately
Equivalent acceptable solution makes acceptable solution remain at 5ml capacity, after sample is filtered with miillpore filter, with HPLC testing index ingredient
Content.And correction drug concentration C is calculated as followsnInfiltration capacity Q, stable state transmission rates Js, infiltration system are accumulated in school, unit area
Number P.
CThe school n=CN is surveyed+0.2/5∑Cp
Wherein CThe school n: calibration model constituent concentration；Cn: actually measured model constituent concentration；
∑ Cp: each the sum of measurement concentration for sampling preceding each point；
Q=CThe school n×V/A
It is mapped with the Q of different time to time t, the straight line portion slope of the figure is stable state transmission rates Js.
P=Js/C0
Wherein P: infiltration coefficient；A: diffusion cell cross-sectional area；V: acceptable solution volume in acceptance pool；C0: for examination in supply pool
Model constituent concentration.
Anti-reflection coefficient=P sample sets/P control group
Assay chromatographic condition:
Chromatographic column: using octadecylsilane chemically bonded silica as filler, HYPERSIL C18Column (4.6 × 300mm, 5 μ)；Flowing
Phase: for methanol-water (85: 15)；Flow velocity: 1mlmin-1；Detection wavelength: 270nm；Sample volume: 10 μ l.
Test result
Under the experiment condition, the addition of small water molecule cluster (TMW) can promote the skin of cosmetic actives to absorb.
Compared with the control group, sample sets can increase the infiltration rate and Percutaneous permeability of the ingredient.
(2) moistening effect
Healthy volunteer 100 are chosen, men and women is fifty-fifty, and the age 20~60 years old, no serious systemic disease was lacked without immune
Fall into or autoimmune disease, no active anaphylactia, to skin-care cosmetics without severe allergy history, it is one month nearly in not
Once hormone medicine or immunosuppressor were used, does not participate in other clinical tests, does not smear the external preparations such as any cosmetics,
Original rule of life is kept in experimentation.
All subjects are tested, moisture content and water loss amount after skin was using lotion 6 hours are averaged.
Skin water and state are tested using moisture of skin measuring instrument Corneometer CM825, is surveyed through skin moisture loss
Measure the water loss amount of instrument Tewameter TM300 test skin.
(3) whitening effect
Healthy volunteer 100 are chosen, men and women is fifty-fifty, and the age 20~60 years old, no serious systemic disease was lacked without immune
Fall into or autoimmune disease, no active anaphylactia, to skin-care cosmetics without severe allergy history, it is one month nearly in not
Once hormone medicine or immunosuppressor were used, does not participate in other clinical tests, does not smear the external preparations such as any cosmetics,
Original rule of life is kept in experimentation.Test subject's skin use lotion 2 months after skin complexion L value variation and
The variation of melanin value H carries out whitening effect assessment.
Skin complexion measurement: the skin color tester produced using Courage+Khazaka (CK) company of Germany
Colorimeter CL400 measures the measurement of target area skin complexion L value, passes through the change of skin L value before and after measurement product use
Change to assess influence of the product to the bright degree of skin.△ L value is bigger, and whitening effect is better.
The measurement of dermal melanin: the dermal melanin and blood produced using Courage+Khazaka (CK) company of Germany
Red pigment measuring instrument MX18 measures melanin value H in skin, and target area dermal melanin measures 5 times, takes its average value, pass through measurement
Dermal melanin numerical value changes to assess the skin whitening efficacy of the product before and after product use.△ H value is smaller, whitening effect
Better.
Test result is shown in Table 1
Table 1
From the above data, it can be seen that preparing small water molecule cluster (TMW), Neng Gouming using method of the present invention
It is aobvious to improve cosmetic active, small water molecule cluster (TMW) to effective component in cosmetics have it is apparent promote permeability energy, and with not
Cosmetics containing small water molecule cluster (TMW) are compared, moisturizing, moisturizing and the beauty of the cosmetics containing small water molecule cluster (TMW)
White effect is obviously improved.
Above-described embodiment is merely illustrative, and is used to explain the present invention the feature and application mode of the method, can not
For limiting the present invention, the attached claims are intended to the range as wide as possible for requiring to be contemplated that, such as in claim
Used in the variant of term "comprising" and its meaning of one's words theoretically also include different expression ways, such as, but not limited to " its
Group becomes ".Embodiment as described herein is only the possible embodiment in part.Therefore, appended claims of the invention is not
It is limited by the example.Some numberical ranges used also include subrange in the claims, these
Variation in range should also be construed to be covered by the attached claims in the conceived case.
Claims (5)
1. a kind of preparation method for the small water molecule cluster TMW for promoting cosmetic active, which is characterized in that comprise the steps of:
(1) liquid water freezing is prepared into ice；
(2) under vacuum conditions, using laser splash ice, small water molecule cluster TMW is generated, the small water molecule cluster TMW is
Plasma state；
The liquid water is mineral water；
The vacuum degree of vacuum condition is 2 × 10 in the step (2)-1Pa~8 × 10-3Pa；The optical maser wavelength for sputtering
For 1064nm；The laser energy for sputtering is 20mJ.
2. the preparation method of small water molecule cluster TMW for promoting cosmetic active according to claim 1 a kind of, feature
It is, the mineral water includes one or more of following metallic element: iron, potassium, magnesium, aluminium, zinc, silver, sodium, titanium.
3. a kind of cosmetics, which is characterized in that the small water molecule group comprising the described in any item method preparations of claim 1~2
Cluster TMW.
4. a kind of preparation method of cosmetics, which is characterized in that comprise the steps of: and cosmetics are placed in magnetic field, continuous
Under stirring, the small water molecule cluster TMW of the described in any item method preparations of claim 1~2 is deposited in cosmetics.
5. a kind of preparation method of cosmetics according to claim 4, which is characterized in that the magnetic induction intensity in the magnetic field
For 0.003~0.8T, frequency is 5~50kHz.
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| US20030035846A1 (en) * | 2000-06-08 | 2003-02-20 | Toshimitsu Hattori | Water having a superior ability to disperse oil and fats |
| EP1365994A1 (en) * | 2001-02-01 | 2003-12-03 | Indevex AB | A method and an apparatus for energizing fluids |
| JP2002035761A (en) * | 2001-05-21 | 2002-02-05 | Toshimitsu Hattori | Water excellent in dispersibility of oils and fats |
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| US9907896B2 (en) * | 2013-06-21 | 2018-03-06 | Taipei Medical University | Apparatus and process for preparation of small water cluster and small molecular cluster water prepared therefrom |
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