CN105708998A - Traditional Chinese medicine composition for preventing and treating chicken coccidiosis and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating chicken coccidiosis and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention provides a traditional Chinese medicine composition for preventing and treating chicken coccidiosis and application thereof and belongs to the technical field of traditional Chinese medicine veterinary drugs. According to the technical scheme, the traditional Chinese medicine composition for preventing and treating chicken coccidiosis is prepared from, by weight, 5-15 parts of radix dichroa, 1-4 parts of betel nuts, 1-5 parts of herba andrographitis, 0.5-5 parts of radix sanguisorbae, 0.5-5 parts of milkvetch roots, 1-5 parts of folium isatidis, 0.5-5 parts of echinacea purpurea and 0.5-5 parts of liquorice roots. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is convenient to use, easy to absorb, remarkable in coccidium resisting effect and reliable in effect; the traditional Chinese medicine composition is in a powder form, is convenient to prepare, store and use, and can be applied and popularized on a large scale; medicinal material resources are rich, and cost is low; a chicken coccidiosis resisting pure traditional Chinese medicine feed additive with a strict technological standard and quality standard is prepared, a good prevention and treatment effect is achieved, the quality of meat and eggs can be improved, and export of the meat and the eggs for earning foreign exchange is promoted.
Description
Technical field
The invention belongs to herbal medicine technical field, be specifically related to a kind of Chinese medicine composition for preventing and treating chicken coccidiosis and application thereof.
Background technology
Just there is Eimeria species in the place having chicken, and chicken coccidiosis is the formidable enemy of poultry husbandry, and its sickness rate is 50 ~ 70%, mortality rate 20 ~ 80%.In various fowl disease, the incidence rate of coccidiosis is the highest, accounts for 1/6 ~ 1/5, and according to statistics, the loss caused because of chicken coccidiosis is often only up to 2,000,000,000 dollars in the whole world, China every year for the expense of anticoccidial drug up to 6～1,800,000,000 yuan.For this, the preventing and treating of chicken coccidiosis is caused the great attention of domestic and international veterinary scientific worker.
The medicine preventing and treating chicken coccidiosis at present has vaccine, Western medicine and herbal medicine three major types, three has prevention effect in various degree, but also all there is more technical problem, at present, to the preventing and treating of this disease still based on chemical synthetic drug and antibiotic, but this situation has made people create worry: first is drug resistance problems, for instance glycamide, nequinate list less than 6 months just because drug resistance is eliminated；Robenidine has also only used within 2 years, just face drug resistance problems at America & Canada；It is known as the ionophore anticoccidial drug monensin never producing drug resistance also because drug resistance problems is extruded market；The highest another ionophore anticoccidial drug Maduramicin in present market share has also created drug resistance.Second is drug residue problem, along with coccidiostat prolonged application for many years, even abuses abuse, curative effect reduces year by year, consumption increases year by year, and Drug resistance worm strain is constantly formed, and has drug residue hidden danger more serious, meat, egg food are constituted a threat to safely, even serious harm human health, feeds continuously such as Robenidine and makes meat, egg produce abnormal flavour, it is impossible to be edible, furazolidone and Maduramicin toxicity are too big, also have the poisoning case etc. that two kinds of medicines often occur in veterinary clinic practice.Some developed countries are more and more highlyer fixed to the chemicals residue criterion of the product such as meat, egg, and formulate regulation and strictly limit or forbid the use as additive of the chemical coccidiostas thing.As the residual quantity of the medicines such as China conventional chemical coccidiostas gram ball powder, Amprolium, sulfanilamide, furazolidone is limited to below 0.1ppm by Japan, this is tantamount to announce that these medicines can not use in the chicken group of outlet Japan, causes I Shandong, Jilin, Guangdong etc. to export to the broiler of Japan and suffers tremendous economic loss because residual exceeds standard.
For overcoming above-mentioned drawback, the research of Chinese medicine class coccidiosis compositions becomes emphasis and the focus of this area, but constitute at formula and and methods for using them exists following defect, because formula is not rigorous, curative effect is not good enough, direct for herbal medicine powder spice is fed by application process, having delayed the sick chicken absorption rate to effective ingredient, prevention effect is unsatisfactory.Therefore, the medicine of preventing and treating chicken coccidiosis being carried out technological innovation is the only way solving the problems referred to above.
Summary of the invention
For solving the technical problem that existing anti-chicken coccidiosis class curative effect of medication is not good enough, side effect is big, the present invention provides a kind of Chinese medicine composition for preventing and treating chicken coccidiosis, adopt and rationally select Chinese medicine medicines the technical scheme with science ratio compatibility, prove through practice test for several times, prevention and the treatment of chicken coccidiosis are all had good result by said composition, and safe and reliable, it is applied to preparation for preventing and treating the medicine of chicken coccidiosis, having great potential for the feed additive or feedstuff preventing and treating chicken coccidiosis.
The technical solution used in the present invention is, a kind of Chinese medicine composition for preventing and treating chicken coccidiosis, including the raw material of following ratio of weight and number: Radix Dichroae 5～15 parts, Semen Arecae 1～4 part, Herba Andrographis 1～5 part, Radix Sanguisorbae 0.5～5 part, the Radix Astragali 0.5～5 part, Folium Isatidis 1～5 part, Echinacea 0.5～5 part and 0.5～5 part of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition includes the raw material of following ratio of weight and number: Radix Dichroae 8～10 parts, Semen Arecae 1～4 part, Herba Andrographis 2～3 parts, Radix Sanguisorbae 1～3 part, the Radix Astragali 1～2 part, Folium Isatidis 2～3 parts, Echinacea 1～3 part and 1～2 part of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition dosage form is powder.
The present invention also provides for the application in preparing the medicine for preventing and treating chicken coccidiosis of the above-mentioned Chinese medicine composition and the application in the feed additive prepared for preventing and treating chicken coccidiosis or feedstuff.
In technique scheme, for preventing and treating the Chinese medicine composition of chicken coccidiosis for designed by theory of Chinese medical science, including Radix Dichroae, Semen Arecae, Herba Andrographis, Radix Sanguisorbae, the Radix Astragali, Folium Isatidis, Echinacea, Radix Glycyrrhizae eight taste herbal raw material, Radix Dichroae: acrid in the mouth, cold, bitter, poisonous, enter lung, the heart, Liver Channel, have the effect treating phlegm retention, malaria in the heart；Semen Arecae: there is the effect of " parasite killing, removing mass, sending down the abnormal ascending QI row are stagnant, row aquation wet "；Herba Andrographis: have antipyretic, antiinflammatory action, for multi-infection disease, toxicity is low；Radix Sanguisorbae: cold in nature, bitter in the mouth is sour, nontoxic, return liver, lung, kidney and large intestine channel, have cooling blood for hemostasis, heat-clearing and toxic substances removing, the clear yin nourishing of training, detumescence effect such as sore；The Radix Astragali: nature and flavor are sweet, warm, enters spleen, lung meridian, has replenishing QI to invigorate the spleen soil, rises effects such as lifting yang-energy, strengthening superficial resistance to stop perspiration, holder skin ulcer granulation promoting, diuretic；Folium Isatidis: bitter in the mouth, cold in nature, returns liver, the heart, harmonization of the stomach spleen channel, has the effect of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing；Echinacea: containing various active composition, there is the effect strengthening immunity；Radix Glycyrrhizae: nature and flavor are sweet, flat, enters 12 warps, has a heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of the blending property of medicine, and can spleen invigorating and in, relieving spasm to stop pain.Radix Dichroae in side, Semen Arecae are the principal agent of anthelmintic parasite killing；Herba Andrographis, Folium Isatidis and Radix Sanguisorbae are accessory drugs；The Radix Astragali, Echinacea replenishing QI to invigorate the spleen, enhancing immunity, for adjuvant drug；Radix Glycyrrhizae spleen invigorating and in, coordinating the actions of various ingredients in a prescription, for making medicine；Above-mentioned each medicine share, and cooperation is mutually improved, and common performance is attacked long-pending parasite killing, circulation of qi promoting spleen invigorating, improved immune effect.Above-mentioned eight Chinese medicine compositions can be made into powder through common process, is conveniently entrained in daily grain of chicken edible.
The present invention also provides for the application in preparing the medicine for preventing and treating chicken coccidiosis of the above-mentioned Chinese medicine composition and the application in the feed additive prepared for preventing and treating chicken coccidiosis or feedstuff.
Technique scheme is adopted to provide the benefit that: the Chinese medicine composition of (1) present invention is easy to use, easily absorbed, anticoccidial effect is notable, effect is reliable；(2) in the technical scheme improved further, it is preferable that powder type, it is simple to make storage and use, it is possible to large scale application is high；Herb resource enriches, and cost is low；Make the chicken pure Chinese medicine feed additive of coccidiosis possessing strict technology standard and quality standard, have well prevention and therapeutic effect, and meat egg quality can be improved, be beneficial to the foreign exchange earning of meat egg.
Detailed description of the invention
Chinese medicine composition and the application thereof for preventing and treating chicken coccidiosis of the present invention are described below by way of specific embodiment.
The present invention provides a kind of Chinese medicine composition for preventing and treating chicken coccidiosis, its raw material includes Radix Dichroae, Semen Arecae, Herba Andrographis, Radix Sanguisorbae, the Radix Astragali, Folium Isatidis, Echinacea and Radix Glycyrrhizae, it is through experimental study gained formula many times, its quality proportioning example such as table 1 below:
The Chinese medicine composition proportioning example (ratio of weight and number number ratio) of chicken coccidiosis prevented and treated by table 1
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Radix Dichroae | 5 | 8 | 8 | 10 | 10 | 15 |
| Semen Arecae | 1 | 2 | 2 | 4 | 4 | 3 |
| Herba Andrographis | 1 | 1 | 3 | 3 | 2 | 5 |
| Radix Sanguisorbae | 0.5 | 1 | 1 | 2 | 3 | 5 |
| The Radix Astragali | 0.5 | 1 | 2 | 3 | 3 | 5 |
| Folium Isatidis | 1 | 2 | 2 | 2 | 5 | 3 2 --> |
| Echinacea | 0.5 | 1 | 2 | 2 | 3 | 5 |
| Radix Glycyrrhizae | 0.5 | 1 | 1 | 2 | 3 | 5 |
Above-described embodiment is the compatibility example of the present invention, but is not used in the restriction present invention, and above-mentioned Chinese medicine composition is that the effect of its preventing and treating chicken coccidiosis is notable through scientific compatibility, and the remarkable result of Chinese medicine composition provided by the present invention is described below by way of concrete test.
Test the curative effect of the Chinese medicine composition preventing and treating chicken coccidiosis of 1 various dose
After the ground pulverizing of Chinese medicine composition of compatibility shown in embodiment 3, by 24 mesh sieves, obtaining the powder (can pass through 65 mesh sieves≤40%) of anti-chicken coccidiosis, the anti-ball of called after dissipates common flour；Above-mentioned powder makes ultrafine powder by 200-400 mesh sieve further, the anti-ball powder ultramicro powder of called after, is added in proportion in complete feed respectively, is mixed evenly, and carries out following prevention experiment and Experiment on therapy.
Part I: prophylactic tria
240 brown laying hen public affairs young birds of Luo Man are randomly divided into 8 groups, and often group 30, is numbered 1-8.1-3 group 3d before infecting coccidian oocyst starts to feed the complete feed adding the anti-ball powder ultramicro powder of 0.5wt.%, 1wt.%, 1.5wt.% respectively, 4-6 group 3d before infecting coccidian oocyst starts to feed the complete feed adding the scattered common flour of the anti-ball of 1wt.%, 1.5wt.%, 3wt.% respectively (it is contemplated that common flour effect will be generally less than superfine powder, it is identical with there being two groups in superfine powder content that common flour content in feedstuff is set, and is provided with one group that adds a large amount of 3wt.% further)；Set 7 groups, 8 groups as a control group simultaneously, 7 groups are not administered group for infection and (infect coccidian oocyst with 1-6 group simultaneously, infect 3d before coccidian oocyst to start to feed complete feed), 8 groups be not administered group (without infecting coccidian oocyst, feed common complete feed) for not infecting.Above-mentioned coccidian oocyst is Eimeria Tenella egg capsule, and the infective dose of every chicken is 1.0 × 105Individual.Each organize equal free choice feeding, fully drink water, medication one week (namely infect coccidian oocyst after 4 days), observing effect, respectively organize the survival rate of test chicken, body weight increase rate, pathological changes value, egg capsule value and anticoccidial index (ACI) result in Table 2.
Part II: therapeutic test
240 brown laying hen public affairs young birds of Luo Man are randomly divided into 8 groups, and often group 30, is numbered 9-16.9-15 group chickling infects Eimeria Tenella egg capsule 1.0 × 10 respectively5Individual/only, 16th group is not infected, when there is coccidiosis symptom in chickling, 9-11 group feeds the complete feed adding the anti-ball powder ultramicro powder of 0.5wt.%, 1wt.%, 1.5wt.% respectively, 11-14 group feeds the complete feed adding the scattered common flour of the anti-ball of 1wt.%, 1.5wt.%, 3wt.% respectively, and the 15th, 16 groups feed complete feed respectively.The equal free choice feeding of each group, fully drinks water, one week observing effect of medication, and each group survival rate of test chicken, body weight increase rate, pathological changes value, egg capsule value and anticoccidial index (ACI) result are in Table 3.
During above-mentioned observing effect, the drug effect criterion of institute's reference is as follows:
Survival rate (%)=(in group internal memory live chickens number/group test chicken sum) × 100%；
Body weight increase rate (%)=(medication group or morbidity are not administered group average weight gain/blank group average weight gain) × 100%；
Pathological changes value and lesion score, caecum lesion is scored by standard by the scoring criteria of Johnson and Reid, and the group average lesion of pathological changes value=often scores × 10, and way of specifically scoring is: when both sides caecum lesion is inconsistent, is as the criterion with serious side, 0 point, without naked eyes pathological changes；+ 1 point, caecum wall has the blood stasis point that minimal amount is dispersed in, and intestinal wall does not thicken, and content is normal；+ 2 points, pathological changes quantity is more, and the obvious band blood of cecal content, caecum wall thickening, content is normal；+ 3 points, cecal content volume blood or have caecum core (blood clot or the caseous Banana Type block of canescence), caecum wall is plump substantially, and in caecum, manure content is few；+ 4 points, because being full of a large amount of blood or intestinal core and caecum enlargement, containing excrement slag or without excrement slag in intestinal core；Dead chicken also remembers+4 points.
Egg capsule value is calculated as egg sac number (OPG) value according to cecal content, calculating egg capsule than number, convert egg capsule value by field, angle clearing method, egg capsule is than number=medication group or does not fall ill and is not administered group egg sac number/morbidity and is not administered group egg sac number × 100%, when egg capsule is 0～1% than number, egg capsule value is 0；When egg capsule is 2%～25% than number, egg capsule value is 5；When egg capsule is 26%～50% than number, egg capsule value is 10；When egg capsule is 51%～75% than number, egg capsule value is 20；When egg capsule is 76%～100% than number, egg capsule value is 40.
Anticoccidial Index A CI=(body weight increase rate+survival rate)-(pathological changes value+egg capsule value), works as ACI > 180, effect assessment is that curative effect is outstanding；ACI is 160-180, and curative effect is good；ACI is 120-160, and curative effect is medium；ACI < 120, weak curative effect.
The effect of table 2 various dose Chinese medicine composition prevention chicken coccidiosis
The effect of table 3 various dose traditional Chinese medicine composition for treating chicken coccidiosis
From above table 2, table 3, the coccidiosis symptom of the 7th group, the 15th group experimental group chicken is the most serious, Chinese medicine composition provided by the invention is notable to prevention and the therapeutic effect of chicken coccidiosis, ratio infects the survival rate not being administered group and body weight increase rate improves nearly 40%, during prevention, the addition to add 0.5wt.% in feedstuff is best, with addition the best of 1wt.% during medicine for treatment, and the prevention effect of superfine powder is better than common flour in every respect.
The superfine powder testing 2 Chinese medicine compositions of the present invention studies the gaining effect to broiler
The Chinese medicine composition of compatibility shown in embodiment 3 is ground, then passes through 200-400 mesh sieve, obtain anti-ball powder ultramicro powder, carry out following test.
300 white plumage broiler chicken of health 1 age in days, it is randomly divided into test group A and matched group B, each 150, the body weight of chicken is often organized when measuring and record 1 age in days, then test group A adds the anti-ball powder ultramicro powder of 1wt.% in chicken feed, matched group B feeds identical chicken feed, without anti-ball powder ultramicro powder, raise in cages, strict broiler chicken method for breeding routinely manages under the same conditions, carry out routine immunization simultaneously, test period is for continuing 42d, respectively the 21st, the TBW often organizing chicken is weighed under fasted conditions when 42 days, and calculate every broiler at 1-21 days, the average daily gain in 22-42 days two stages, average daily gain (g/ sky)=(end weighs a starting weight)/interval natural law, result is shown in table 4 below,
The impact of table 4 anti-ball powder ultramicro powder dialogue plumage broiler chicken weightening finish
As can be seen from the table, the initial weight difference of each group not notable (P>0.05), the 1-21 age in days experimental stage, test group is increase compared with matched group, and daily gain improves 3.2%, significant difference (P<0.05)；22-42 age in days experimental stage test group increase compared with matched group, daily gain improves 5.9%, difference extremely notable (P < 0.01), illustrates that broiler is had obvious gaining effect by the anti-ball powder ultramicro powder that the Chinese medicine composition of the present invention is made.
The superfine powder testing 3 Chinese medicine compositions of the present invention studies the impact of laying eggs on laying hen
Ground by the Chinese medicine composition of compatibility shown in embodiment 4, mistake 200-400 mesh sieve makes anti-ball powder ultramicro powder, carries out following test.
300 160 healthy ages in days are in the brown laying hen of Luo Man of laying period, it is randomly divided into test group C and matched group D, test group C feeds the laying period feedstuff adding the anti-ball powder ultramicro powder of 1wt.%, and matched group D feeds common laying period feedstuff, without anti-ball powder ultramicro powder, management under strict feeding method of laying chicken equal conditions routinely, raise in cages, free choice feeding and drinking-water, test period 60d, the egg production that accurate recording is often organized and weight of laying eggs, result is shown in table 5 below.
The impact on the brown laying rate of laying hen of Luo Man of the table 5 anti-ball powder ultramicro powder
| Group | Group number | Per day laying rate (%) | Average egg weight (g) |
| Test group | C | 94 | 62.1 |
| Matched group | D | 86 | 58.8 |
No matter from laying rate or average egg weight, test group C is apparently higher than matched group D, and wherein laying rate improves 8%, and average egg weight improves 5.6%, illustrates that anti-ball powder ultramicro powder can improve the laying rate of laying hen, increases egg size.
Test 4 is with the impact on chicken immune function of the superfine powder of Chinese medicine composition shown in embodiment 4
Before test, test is carried out stool examination with chicken by continuous 2d, after confirming that non-ball worm infects, with reference to the method for Suo Xun, 90 20 age in days tests are selected to weigh, number by only empty stomach morning with chicken, it is randomly divided into I, II, III 3 groups, often group 30, the group that local directed complete set bodyweight difference is bigger so that each group average weight is roughly equal, packet situation is as follows: the Ith group, for infecting administration group, feeds and add the superfine powder of Chinese medicine composition shown in 1wt.% embodiment 4 on the basis of normal feedstuff；IIth group is not administered group for infecting, feeds normal feedstuff；IIIth group is not administered group for not infecting, feeds normal feedstuff.Within 1st day, determine dose to the Ith group of administration by above-mentioned setting；2nd day morning, except the IIIth group, other two groups every chickling oral vaccination E.tenella Sporulated Oocysts 1 × 105Individual.Respectively at infect before (first day, i.e. 20 age in days) and infect after the 7th, 14,21 days (namely 27 ages in days, 34 ages in days, 41 ages in days), often group takes 5 every time, to chicken Culling heart blood (totally 4 times), takes requirement blood when being not added with anticoagulant, room temperature stands 1h, 2000r/min is centrifuged 10min, separates serum, and-20 DEG C save backup, for measuring serum immune globulin, result is in Table 6.
When 42 age in days, measure the peripheral T lymphocyte value often organizing chicken, assay method is, often group randomly draws 5 chickens, wing venous blood collection 1 dripping becomes blood smear, every chicken is cooked 2 blood sheets, and α-naphthylacetate enzyme process (acid-α-naphthylacetateesterase, ANAE) direct smear staining obtains corresponding ANAE+The lymphocytic percentage rate of T, result is in Table 7.
When 42 age in days, measure the Immune Organs Index often organizing chicken, assay method is, often group extracts 5 chickens, slaughter after weighing exactly with electronic balance, win thymus, spleen and fabricius bursa, pick most fat and other tissue, blot surface liquid and claim fresh weight with electronic balance again, with reference to following computing formula Computation immunity shoot formation, thymus index=thymus fresh weight/chicken body weight；Index and spleen index=spleen fresh weight/chicken body weight；Bursal index=fabricius bursa fresh weight/chicken body weight；Result is in Table 8.
Table 6IgG determination of immunoglobulin result (g L-1)
| Group | Group number | 20 ages in days | 27 ages in days | 34 ages in days | 41 ages in days |
| Infect administration group | Ⅰ | 4.31±0.82 | 4.41±0.89 | 5.86±1.09 | 5.21±0.68 |
| Infect and be not administered group | Ⅱ | 4.34±1.01 | 4.54±0.88 | 5.81±0.84 | 5.41±0.76 |
| Do not infect and be not administered group | Ⅲ | 4.35±0.77 | 4.33±0.62 | 4.35±0.79 | 4.21±0.73 |
As seen from the data in Table 6, infection administration group and infection are not administered the IgG antibody of group and gradually rise after infecting the 7th day, until all keeping higher level on the 21st day, are not administered group higher than not infecting, wherein within the 14th day, peak, illustrate that coccidium infection can cause the immunne response of chicken body；Infect the IgG content trend of administration group for gradually rising and continuing for some time, illustrate that anti-ball powder ultramicro powder group has the effect improving body's immunity.
Table 7 peripheral blood ANAE+The change (%) of T lymphocyte number
| Group | Group number | T lymphocyte number change (%) |
| Infect administration group | Ⅰ | 52.4 |
| Infect and be not administered group | Ⅱ | 45.4 |
| Do not infect and be not administered group | Ⅲ | 47.3 |
As can be seen from Table 7, infect the periphery blood T lymphocyte number of administration group apparently higher than other two groups, significant difference (P < 0.05), illustrates that the Chinese medicine composition superfine powder of the present invention can strengthen T lymphocyte number in chicken peripheral blood, has the effect strengthening chicken body immunity function.
The measurement result of table 8 Immune Organs Index
| Group | Group number | Thymus index | Index and spleen index | Bursal index 6--> |
| Infect administration group | Ⅰ | 0.184±0.04 | 0.163±0.02 | 0.211±0.02 |
| Infect and be not administered group | Ⅱ | 0.158±0.02 | 0.153±0.03 | 0.176±0.01 |
| Do not infect and be not administered group | Ⅲ | 0.163±0.02 | 0.140±0.01 | 0.187±0.02 |
Table 8 data show, when 42 age in days, the Immune Organs Index of infection administration group is all higher than infecting not being administered to organize and do not infect and is not administered group, and difference extremely notable (P < 0.01) illustrates that the Chinese medicine composition superfine powder of the present invention can promote the growth of immune organs of chicken treated.
Test the toxicity test of 5 Chinese medicine composition superfine powder
Start to raise when 1 age in days, for examination after 1 week, during test, carry out newcastle, infections bursal disease and fowl pox vaccine immunity by normal immune programme for children.Selecting 80 chickling during 1 week old from 100 chickling, be randomly divided into E, F, G, H group, often group 20, weighs respectively, raises in cages, and E, F, G group is test group, and H group is blank group.From 2 week old, the feedstuff of E, F, G group chicken is pressed 1wt.%, 5wt.%, 10wt.% respectively and adds the Chinese medicine composition superfine powder shown in embodiment 4, when all chicken free choice feedings, observe every day each group of chicken activity, search for food, drink water, health status etc., weigh weekly 1 time, record food consumption situation.Take a blood sample when 8 week old, carry out hematology and Biochemical Indices In Serum measures, during 8 week old off-test, all experimental animals are cutd open inspection, carry out pathological examination weigh its heart, liver, spleen, stomach.
Experimental result: during test, each organize chicken activity, search for food, drinking-water etc. all normal, health status is all good.Cuing open seizure test chicken after off-test, each internal organs do not find macroscopic pathological change, and concrete indices measurement result is in Table 9～11.
Test chicken Gain weight respectively organized by table 9
Test chicken hematological indices measurement result respectively organized by table 10
Test chicken blood parameters measurement result respectively organized by table 11
Visible according to table 9-11 data, hematology, Biochemical Indices In Serum mensuration all do not find the Novel presentation relevant with medicine, illustrate superfine powder that the Chinese medicine composition of the present invention makes to the toxicity of chicken almost without, it was shown that this Chinese medicine composition safety non-toxic, it is possible to further apply clinical trial.
Test the clinical verification of 6 Chinese medicine composition superfine powder
1. prophylactic tria
2013, Handan plant environment is poor, coccidiosis recurrent exerbation, choose the prophylactic tria that 1000 blue brown laying hens in sea investigate the Chinese medicine composition of the present invention as test chicken, be randomly divided into test group and matched group, each 500, test group feedstuff adds Chinese medicine composition superfine powder shown in 0.5wt.% embodiment 4, matched group is without any medicine, and other conditions are identical, observes prevention disease event and application effect.
On June 25th, 2013, the unexpected popular morbidity of coccidiosis of this plant, according to epidemic characteristic, clinical symptoms performance, cut open inspection pathological change and microscopy result, find that feeding the blue brown laying hen in 500 seas of test group adding 0.5wt.% anti-ball powder ultramicro powder is all uninfected by morbidity, and the infected coccidiosis of matched group 60%, prevention disease result of the test shows, anti-ball powder ultramicro powder is obvious to prevention chicken coccidiosis effect, prevention rate reaches 100%, improve 40% than matched group, greatly reduce to the economic loss of plant.
2. therapeutic test
On May 16th, 2013, the brown laying hen sudden onset of Shijiazhuang plant Luo Man, according to epidemic characteristic, clinical symptoms performance, cut open inspection pathological change and microscopy result, just diagnosis is coccidiosis.Select 1800 model cases for therapeutic test, disease chicken is randomly divided into three groups, often group 600, test group feeds the feedstuff containing the anti-ball powder ultramicro powder of 1wt.%, drug control group feeds the feedstuff of the commercially available diclazuril pre-mixing agent containing 1wt.%, and without any medicine in the feedstuff of blank group, administrated method is mixes interpolation feed in feedstuff by medicine, all the other feeding methods are all identical with under management condition, observe the clinical symptoms of its disease, pathological change and mortality rate.
It was found that test group continuous use 5 days, in 600 test chickens except dead 12, other chickens are all cured, transference cure, search for food normal, and mortality rate is 2%, cure rate 98%；By the drug control group of diclazuril pre-mixing agent, after medication 3 days, symptom alleviates, but death occurs, the 4th day symptom of medication disappears substantially, but extremely indivedual chicken also has and has loose bowels or just shape is not whole, sick chicken transference cure after medication 5 days, recover feed intake, always having 48 chicken deaths, mortality rate is 8%, and cure rate is 92%；600 chickens of blank group, dead 120 of untreated when 5 days, 20 days dead 358 of untreated, mortality rate reaches 59.7%, exceeds 6% than the cure rate of current medicine, exceed 38% than not medication group when the Chinese medicine composition superfine powder of the present invention is for treating chicken coccidiosis.
As fully visible, the Chinese medicine composition of the present invention is good to the prevention effect of chicken coccidiosis, prevention effective percentage and cure rate all reach more than 98%, more excellent than the effect of drugs of anti-chicken coccidiosis conventional at present, and toxicity is little, the immunologic function of chicken body and meat egg yield and quality can also be effectively improved, in preparation for preventing and treating in the medicine of chicken coccidiosis and in preparation for preventing and treating the feed additive of chicken coccidiosis or specially there are great potentiality in the application in effect feedstuff etc., aquaculture industry will be brought good economic well-being of workers and staff, reduce accidental loss.
Claims (10)
1. the Chinese medicine composition being used for preventing and treating chicken coccidiosis, it is characterized in that, including the raw material of following ratio of weight and number: Radix Dichroae 5～15 parts, Semen Arecae 1～4 part, Herba Andrographis 1～5 part, Radix Sanguisorbae 0.5～5 part, the Radix Astragali 0.5～5 part, Folium Isatidis 1～5 part, Echinacea 0.5～5 part and 0.5～5 part of Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1, it is characterised in that: described Chinese medicine composition includes the raw material of following ratio of weight and number: Radix Dichroae 8～10 parts, Semen Arecae 1～4 part, Herba Andrographis 2～3 parts, Radix Sanguisorbae 1～3 part, the Radix Astragali 1～2 part, Folium Isatidis 2～3 parts, Echinacea 1～3 part and 1～2 part of Radix Glycyrrhizae.
3. Chinese medicine composition according to claim 1 and 2, it is characterised in that: the consumption that makes when described Chinese medicine composition is for preventing chicken coccidiosis is the 0.1-0.7wt.% accounting for normal feedstuff.
4. Chinese medicine composition according to claim 3, it is characterised in that: the consumption that makes when described Chinese medicine composition is for preventing chicken coccidiosis is the 0.5wt.% accounting for normal feedstuff.
5. Chinese medicine composition according to claim 1 and 2, it is characterised in that: the consumption that makes when described Chinese medicine composition is for treating chicken coccidiosis is the 0.8-1.5wt.% accounting for normal feedstuff.
6. Chinese medicine composition according to claim 5, it is characterised in that: the consumption that makes when described Chinese medicine composition is for treating chicken coccidiosis is the 1.0wt.% accounting for normal feedstuff.
7. Chinese medicine composition according to claim 1, it is characterised in that: described Chinese medicine composition dosage form is powder.
8. the Chinese medicine composition according to claim 1 or 7, it is characterised in that: described Chinese medicine composition is size-reduced, cross 200-400 mesh sieve after be mixed evenly, powder.
9. the application in preparing the medicine for preventing and treating chicken coccidiosis of the Chinese medicine composition described in claim 1.
10. the Chinese medicine composition described in claim 1 is used for preventing and treating the application in the feed additive of chicken coccidiosis or feedstuff in preparation.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308235A (en) * | 2017-06-27 | 2017-11-03 | 齐全农牧集团股份有限公司 | A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis |
| CN107865250A (en) * | 2017-12-15 | 2018-04-03 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing and treating chicken coccidiasis and preparation method thereof |
| CN108853197A (en) * | 2017-12-04 | 2018-11-23 | 南京农业大学 | It is a kind of for preventing and treating the pharmaceutical composition of chicken coccidiasis |
| CN110100950A (en) * | 2019-06-19 | 2019-08-09 | 山东省农业科学院家禽研究所 | A kind of composite feed additive of substitute antibiotics prevention and treatment chicken coccidiasis |
-
2016
- 2016-03-22 CN CN201610163671.9A patent/CN105708998A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| <中医堂>编委会: "《食物药效全典》", 30 April 2015 * |
| 胡功政等: "《家禽常用药物及其合理使用》", 30 September 2010, 河南科学技术出版社 * |
| 郑继方等: "《常用兽医临床新用》", 31 March 2007, 金盾出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308235A (en) * | 2017-06-27 | 2017-11-03 | 齐全农牧集团股份有限公司 | A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis |
| CN108853197A (en) * | 2017-12-04 | 2018-11-23 | 南京农业大学 | It is a kind of for preventing and treating the pharmaceutical composition of chicken coccidiasis |
| CN107865250A (en) * | 2017-12-15 | 2018-04-03 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing and treating chicken coccidiasis and preparation method thereof |
| CN110100950A (en) * | 2019-06-19 | 2019-08-09 | 山东省农业科学院家禽研究所 | A kind of composite feed additive of substitute antibiotics prevention and treatment chicken coccidiasis |
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