CN105688171B - Feed additive for chicks and preparation method thereof - Google Patents

Abstract

The invention discloses a feed additive for chicks and a preparation method thereof, wherein the feed additive comprises the following raw material medicines: pinellia ternate, poria cocos, ginger, honey locust, perilla fruit, dried orange peel, mangnolia officinalis, semen brassicae, platycodon grandiflorum, nephelin cream, semen benincasae, perilla leaf, cacumen tamaricis, almond, inula flower, cynanchum glaucescens, chrysanthemum indicum, eucalyptus tenuifolia, centipeda minima, matsutake mushroom, watermelon peel, schizonepeta, parsley, divaricate saposhnikovia root and liquorice. The invention has the beneficial effects that: the feed additive has the curative effects of reducing phlegm, relieving cough and asthma, relieving exterior syndrome and dispelling cold, and has the advantages of obvious curative effect, low side effect, high cure rate, short course of treatment, difficult relapse and the like when being used for treating the wind-cold type cough and asthma of the chicken.

Description

Feed additive for chicks and preparation method thereof

The scheme is a divisional application, and the original application name is as follows: the application date of the original application is as follows: 2014-03-20, the application number of the original application is: 201410103548.9.

Technical Field

The invention relates to the technical field of feed additives, and particularly relates to a feed additive for chicks and a preparation method thereof.

Background

The chicken normally breathes 20-40 times per minute, and the asthma is caused when the breathing frequency is accelerated. Some are accompanied by mouth-opening breathing and wheezing. Chicken asthma is most easily heard when the flock is quiet at night. The chicken can breathe rapidly due to stress such as high temperature, stuffiness and the like, and one or more diseases can cause the chicken to asthma and have other respiratory symptoms, wherein some diseases are called respiratory syndrome (symptoms), or are directly called respiratory symptoms and respiratory diseases of the chicken.

The chicken cough and asthma pathogen has both bacteria and viruses, and some have mixed infection. The traditional veterinary medicine considers that six exogenous pathogenic factors affect the lung, phlegm and saliva block the trachea to cause cough and asthma, and then the pathogenic factors spread to the qi system to block the lung machine, so that the cough and asthma are relieved, the qi is reversed, and the breath is obstructed. The symptoms include fever, 1-2 ℃ rise of body temperature, thirst, mouth opening gasping, neck stretching and head raising, wheezing sound in breathing, and worse night, and the patients with chicken cough with bloody silk sputum, congestion and swelling of throat mucosa, pseudomembranous mantle coating and purple coronary beard. The sick chicken seriously faintly feel stubborn, even twitch and paralyzed till death.

The asthma is considered by Chinese veterinarian to be a disease which is mainly characterized clinically by dyspnea caused by external infection or internal injury, lung qi failing to disperse and descend, lung qi adverse rising or qi failing to control, and kidney failure. Ancient literature on asthma is also called "snuff", "shoulder rest", "upward", "adverse qi", "dyspnea" and the like. The interior Jing has more discussion about asthma. For example, in Ling Shu & Wu Yu Wu Shi (Ling Shu & Wu Yu Wu Shi): patients with lung diseases, wheeze and nose. "Su Wen & Tan Tong Lun" (Su Wen & Tan Tong Lun) says: "fatigue causes wheezing and sweating. "indicates that the pathogenesis of asthma is different from deficiency or excess due to external infection and internal injury. In addition, the "plain questions and Bi Lun" (plain questions and Bi Luns) cloud: for heart impediment, obstructed vessels and restlessness lead to the heart bulging downward and rapid upward and dyspnea. "Su Wen, Jing Mai Bing Lun" (plain questions, Jing Mai Bie Lun); "some tenesmus and terrorism, panting on the liver. "although it is mainly indicated for dyspnea, it also relates to the zang-fu organs. The asthma is caused by complicated causes, invasion of exogenous pathogenic factors, improper diet and the like, which all can cause the asthma, and the asthma is caused by lung qi loss and descending, lung qi upward reversal or failure of qi domination, and kidney failure to take in water. Exogenous pathogenic factors invade exogenous pathogenic wind-cold or wind-heat, and fail to disperse in time, and pathogenic factors are accumulated in the lung, obstructing the lung qi, and the lung qi cannot disperse and descend, so the adverse rising of the lung-qi causes asthma. If kidney yang is weakened, kidney failing to dominate water, water pathogen attacking upwards, dry lung attacking heart, lung qi adverse rising, heart yang failing to vibrate, it is also called as dyspnea, which is the condition of deficiency-middle energizer excess. The location of asthma, the main zang-organs are in the lung and kidney, and are related to the liver, spleen and heart. Because the lung governs qi, governs respiration, and joins skin and hair externally, and the interior is the canopy of five zang organs, if exogenous pathogenic factors attack the lung or its zang organs attack the qi, it can cause the lung qi to be obstructed, the lung fails to disperse and descend, and dyspnea are caused by adverse respiration, or the lung qi is weakened and qi is lost and dyspnea are caused. Kidney is the root of qi and governs qi's the lung's discharge and reception, so kidney qi is not fixed, qi fails to enter the original qi due to abnormal absorption and yin and yang are not connected, or qi goes against the lung surface to cause dyspnea. If the spleen is deficient in phlegm and turbid pathogenic fluid or the adverse rise of liver qi can also cause asthma, the liver-spleen disease affects the lung. The heart-qi failing to breathe normally occurs when the patient is taking a breath.

The pathological nature of asthma is of deficiency or excess type. Excessive asthma in the lung, manifested as exogenous pathogenic factors, turbid phlegm, adverse flow of qi due to stagnation of liver qi, and obstruction of pathogenic qi in the lung, which makes the lung disperse and descend unfavorably; deficient dyspnea is caused by deficiency of both lung and kidney, which leads to failure of the lung to control qi and failure of the kidney to receive qi due to deficiency of essence and qi and yin. Therefore, the basic pathogenesis of asthma is disorder of qi movement, i.e., excessive in the lung and deficient in the kidney. For complicated conditions, the patients may have both deficiency syndrome and excess syndrome. However, in different stages of the disease, there is a strong emphasis on the conversion between deficiency and excess or vice versa. If the lung disease is accompanied by the spleen and the son steals the mother's qi, the spleen qi is also deficient, the spleen deficiency fails to transport, the dampness accumulates to generate phlegm, which may invade the lung, the lung qi is obstructed, the qi and fluids are distributed, the blood circulation is disturbed, and phlegm turbidity and blood stasis may be formed, at which the pathogenesis is mainly excess of pathogenic factors or the excess of pathogenic factors and deficiency of vital qi are seen. If the prolonged period of time does not reach the kidney, the pathogenesis of the disease is the syndrome of kidney deficiency and lung excess with phlegm-stasis in the lung. If yang qi is deficient and water is absent, water will overflow and enter heart and lung, and the pathogenesis is that deficiency causes excess and deficiency-excess are seen together. The Chinese veterinarian can be classified into four types according to the cause and syndrome differentiation: wind-cold type cough: acute onset, respiratory distress, cough, watery nasal discharge, foam secretion in eyes, gurgling sound in trachea, eyelid swelling, intolerance of cold and crowding; cough and dyspnea due to phlegm-heat: the cough is dry and comfortable, the mouth is dry and hot, the cough is loud and the breath is urgent, the throat has phlegm and tinnitus, the neck is stretched, the mouth is opened to breathe, the exhaled breath is scorched, the nose is thick, blood mucus is often coughed in some cough, and the throat and the trachea are blocked by phlegm and saliva to cause suffocation and death. Green thin manure is discharged, and some lime water samples are discharged, so that the water intake is increased; cough and dyspnea due to summer-heat and dampness: summer heat is moderate, and long summer is rich in moisture. When the pathogenic summer-heat and dampness invades the chicken, the affected chicken presents mental depression, breath opening, cough or tracheal rale, anorexia, drinking water and pre-treating sharp increase, crop swelling, diarrhea, broiler growth stagnation and egg yield reduction of laying hens; cough with deficiency: it is usually not cured for a long time, but the sick chicken are weak and weak, have poor appetite, breathe too much and inhale less, move and asthma or cough, but have low and short sound.

In recent years, respiratory diseases of chickens are endemic in China, the general incidence rate is 30-40%, and the respiratory diseases are mainly manifested by dyspnea, cough, wheeze and the like. After the disease is infected, the chicks grow slowly or stop, the egg yield of the laying hens is greatly reduced, and some sick chicken groups die, so that serious harm is caused to the chicken industry, and great economic loss is caused. The causes of respiratory diseases of chickens are very complex, and pathogenic infections such as viruses, bacteria, mildews and the like are related to environmental factors such as unclean air, sudden air temperature and the like, so that great difficulty is brought to clinical diagnosis and prevention. The disease is mainly treated by vaccine prevention, chemical drugs, antibiotics and the like at present, and the effect is not ideal.

Disclosure of Invention

The invention aims to solve the technical problem of providing the chick feed additive with the curative effects of reducing phlegm, relieving cough and asthma, relieving exterior syndrome and dispelling cold, and the chick feed additive has the advantages of good curative effect, short treatment course and no toxic or side effect when being used for treating the chicken cough and asthma due to wind-cold.

In order to solve the technical problems, the invention provides a feed additive for chicks, which comprises the following raw material medicines: pinellia ternate, poria cocos, ginger, honey locust, perilla fruit, dried orange peel, mangnolia officinalis, semen brassicae, platycodon grandiflorum, nephelin cream, semen benincasae, perilla leaf, cacumen tamaricis, almond, inula flower, cynanchum glaucescens, chrysanthemum indicum, eucalyptus tenuifolia, centipeda minima, matsutake mushroom, watermelon peel, schizonepeta, parsley, divaricate saposhnikovia root and liquorice.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 10-20 parts of pinellia ternata, 15-25 parts of poria cocos, 10-23 parts of ginger, 10-20 parts of gleditsia sinensis lam, 10-18 parts of perilla fruit, 20-30 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 10-20 parts of semen brassicae, 10-19 parts of platycodon grandiflorum, 10-18 parts of cyanea extract, 10-20 parts of semen benincasae, 10-21 parts of perilla leaf, 10-20 parts of cacumen tamaricis, 10-20 parts of almond, 10-20 parts of inula flower, 10-18 parts of cynanchum glaucescens, 10-30 parts of chrysanthemum indicum, 10-25 parts of eucalyptus leptostachya, 10-20 parts of centipeda minima, 10-20 parts of matsutake, 10-19 parts of exocarpium citrulli, 10-24 parts of schizonepeta tenuifolia, 10-19 parts of jerusal pars, 10-20 parts of divaricate saposhnikovia root and 10-30 parts of liquorice.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 13-16 parts of pinellia ternata, 19-23 parts of poria cocos, 14-21 parts of ginger, 12-17 parts of gleditsia sinensis, 12-15 parts of perilla fruit, 23-28 parts of dried orange peel, 15-25 parts of mangnolia officinalis, 12-16 parts of semen brassicae, 13-19 parts of platycodon grandiflorum, 10-15 parts of cyanea extract, 14-20 parts of semen benincasae, 14-19 parts of perilla leaf, 12-18 parts of cacumen tamaricis, 13-17 parts of almond, 13-20 parts of inula flower, 13-18 parts of cynanchum glaucescens, 16-25 parts of chrysanthemum indicum, 13-21 parts of eucalyptus leptostachya, 13-20 parts of centipeda minima, 10-16 parts of matsutake, 10-14 parts of watermelon peel, 14-20 parts of schizonepeta, 13-19 parts of parsley, 13-19 parts of rhizoma pinelliae, rhizoma pinelliae, 13-18 parts of divaricate saposhnikovia root and 15-23 parts of liquorice.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 21 parts of poria cocos, 17 parts of ginger, 14 parts of honey locust, 14 parts of perillaseed, 25 parts of dried orange peel, 20 parts of mangnolia officinalis, 14 parts of white mustard seed, 16 parts of platycodon grandiflorum, 13 parts of cyanea, 16 parts of waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen tamaricis, 15 parts of almond, 17 parts of inula flower, 14 parts of cynanchum glaucescens, 21 parts of aster ageratoides, 16 parts of eucalyptus tenuifolia, 17 parts of centipeda minima, 13 parts of matsutake, 12 parts of watermelon peel, 17 parts of schizonepeta, 16 parts of parsley, 15 parts of divaricate saposhnikovia root and 17 parts of liquorice.

The feed additive preferably further comprises: herba Lespedezae Cuneatae, herba Tetragoniae Yunnanensis, rhizoma Dioscoreae, Ganoderma and fructus crataegi.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 10-20 parts of pinellia ternata, 15-25 parts of poria cocos, 10-23 parts of ginger, 10-20 parts of gleditsia sinensis lam, 10-18 parts of perilla fruit, 20-30 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 10-20 parts of semen brassicae, 10-19 parts of platycodon grandiflorum, 10-18 parts of cyanea extract, 10-20 parts of semen benincasae, 10-21 parts of perilla leaf, 10-20 parts of cacumen tamaricis, 10-20 parts of almond, 10-20 parts of inula flower, 10-18 parts of cynanchum glaucescens, 10-30 parts of chrysanthemum indicum, 10-25 parts of eucalyptus leptostachya, 10-20 parts of centipeda minima, 10-20 parts of matsutake, 10-19 parts of exocarpium citrulli, 10-24 parts of schizonepeta tenuifolia, 10-19 parts of jerusal pars, 10-20 parts of divaricate saposhnikovia root, 10-30 parts of liquorice, 10-20 parts of herba lespedezae, 10-20 parts of tetragonia, 15-25 parts of Chinese yam, 15-30 parts of lucid ganoderma and 10-15 parts of hawthorn.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 20 parts of poria cocos, 17 parts of ginger, 15 parts of gleditsia sinensis, 14 parts of perillaseed, 25 parts of dried orange peel, 18 parts of mangnolia officinalis, 15 parts of white mustard seed, 14 parts of platycodon grandiflorum, 14 parts of nephelinum paste, 15 parts of Chinese waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen cheiraeae, 15 parts of almond, 15 parts of inula flower, 14 parts of cynanchum glaucescens, 20 parts of chrysanthemum indicum, 17 parts of eucalyptus tenuifolia, 15 parts of centipeda minima, 15 parts of typhonium giganteum, 14 parts of watermelon peel, 17 parts of schizonepeta, 14 parts of parsley, 15 parts of divaricate saposhnikovia root, 20 parts of liquorice, 15 parts of herba lemanensis, 15 parts of armeniaca amara, 21 parts of Chinese yam, 21 parts of ganoderma lucidum and 12 parts of hawthorn.

In order to better achieve the above object, the present invention further provides a preparation method of the feed additive for chicks, wherein the preparation method comprises the following steps:

step one, putting all raw material medicines into a stirrer according to a certain proportion, stirring and mixing, then sending into a grinder for grinding, putting the ground traditional Chinese medicine composition into a multifunctional extraction tank, adding water which is 5 ~ 7 times of the mass of the traditional Chinese medicine composition, boiling for 2 ~ 4 hours, treating under the steam pressure of 0.6 ~ 1Mpa, and filtering to obtain a first filtrate and filter residue;

step two, adding water which is 5 ~ 7 times of the obtained filter residue into the obtained filter residue again, boiling for 2 ~ 4 hours, treating the filter residue under the steam pressure of 0.6Mpa ~ 1Mpa, and filtering to obtain a second filtrate and the filter residue;

and step three, combining the first filtrate and the second filtrate, concentrating to remove water to obtain dry paste, crushing by using an ultra-fine powder mill to obtain feed additive powder, wherein the powder is crushed to be less than 30 mu m.

The technical scheme provided by the embodiment of the invention has the following beneficial effects: the feed additive has the curative effects of reducing phlegm, relieving cough and asthma, relieving exterior syndrome and dispelling cold, and has the advantages of obvious curative effect, low side effect, high cure rate, short course of treatment, difficult relapse and the like when being used for treating the wind-cold type cough and asthma of the chicken.

Detailed Description

The embodiment of the invention provides a feed additive for chicks, which comprises the following raw material medicines: pinellia ternate, poria cocos, ginger, honey locust, perilla fruit, dried orange peel, magnolia officinalis, semen brassicae, platycodon grandiflorum, nephelinum paste, Chinese waxgourd seed, perilla leaf, cacumen cheiraeae, almond, inula flower, cynanchum glaucescens, chrysanthemum indicum, eucalyptus tenuifolia, centipeda minima, matsutake mushroom, watermelon peel, schizonepeta, parsley, divaricate saposhnikovia root and liquorice; preferably, the feed additive preferably further comprises: herba Lespedezae Cuneatae, herba Tetragoniae Yunnanensis, rhizoma Dioscoreae, Ganoderma and fructus crataegi.

The pharmacological characteristics of the raw medicinal materials are as follows:

pinellia ternata: pungent, warm, toxic; enters the lung, spleen and stomach meridians. Treatise on herb Property: "Xiaoyangsi", appetizing and invigorating spleen, stopping vomiting, removing phlegm fullness in chest, descending lung qi, and mainly treating cough. "(Rihuazi Ben Cao >): it is indicated for regurgitation, cholera, spasm of tendons, cold intestine and abdomen, and phlegm malaria. The pungent, warm, dry and toxic herbs with the actions of dispersing and warming, enter spleen and stomach and lung, and can move water and dampness, descend adverse qi and remove damp-phlegm from spleen and stomach. Water-damp removing can strengthen the spleen and self-eliminate phlegm and saliva, and adverse qi descending can relieve stomach harmony and vomiting, so it is a good herb for drying dampness and resolving phlegm, checking adverse qi and relieving vomiting, relieving stuffiness and resolving masses. It is used for treating excessive phlegm due to spleen damp-phlegm, cough with dyspnea, and dizziness, palpitation, insomnia due to damp-phlegm invasion, and also can be used for treating wind-phlegm, headache, limb numbness, hemiplegia, facial distortion, etc.

Tuckahoe, poria cocos: sweet, bland and mild. They enter heart, lung, spleen and kidney meridians. The functions are as follows: a diuretic; dampness-excreting and diuresis-inducing herbs. The method of medication administration: poria, a holy drug that is bland in property and beneficial to the orifices, sweet in flavor and capable of supporting yang and removing dampness, is also used. Sweet and neutral in flavor, tonifying yang, invigorating spleen, expelling water, promoting the production of body fluid and guiding qi. Modern researches show that Poria has the function of enhancing immunity and can regulate immunity in many ways. The tuckahoe has obvious inhibiting effect on staphylococcus aureus and proteus.

Ginger: the rhizoma Zingiberis recens refers to root tuber of Zingiber plant, and is also called Zijiang, rhizoma Zingiberis recens, fresh rhizoma Zingiberis recens, or old rhizoma Zingiberis recens. The special gingerol has warm property, can stimulate gastrointestinal mucosa, cause gastrointestinal congestion and enhance digestive ability, and can effectively treat abdominal distension, abdominal pain, diarrhea, vomiting and the like caused by excessive cold and cool food. After eating the ginger, people can feel hot because the ginger can expand blood vessels, accelerate blood circulation and promote pores on the bodies to open, so that redundant hot tapes can be removed, and pathogenic bacteria and cold air in the bodies can be brought out together. When people eat cold and cool objects, are drenched or stay in an air-conditioned room for a long time, various discomforts caused by the cold weight of the body can be eliminated in time by eating the ginger.

And (3) gleditschia horrida: pungent and warm; enter lung and liver meridians. Compendium of materia Medica: "Zao jiao Ci thorn treats wind and kills parasites, and its action is the same as pod, but its sharpness directly reaches the diseased part, which is different ear. Contains flavone glycoside, phenol and amino acid. The flavonoids are fustin (3, 7, 3, 4-tetrahydroxydihydroflavone), fisetin (3, 7, 3, 4-tetrahydroxyflavone), and colorless anthocyanin. In vivo experiment shows that it has inhibitory activity on turbid mouse sarcoma-180. The decoction can be used for inhibiting Staphylococcus aureus and Catalpa by punching holes on plate; the inhibition rate of 60g/kg of water infusion agent to the sarcoma-180 by intragastric administration is 32.8%. The Chinese honey locust is a drastic and drastic product for dissipating, does not have hardness, does not break, does not have phlegm, can open and close stagnation, is used for treating the phlegm retention syndrome, and can be used for emergency treatment. When the ulcer has protruded, it is broken by the Chinese honeylocust to replace the knife when the ulcer is not broken, so that the ulcer is very powerful.

And (3) Perilla seed: pungent and warm. It enters lung and large intestine meridians. The book of materia Medica: suzi is very quick in dispersing qi, can clear and relieve the upper and lower qi, has the effective function of relieving asthma and phlegm, can relieve constipation and remove wind-cold-dampness arthralgia. It is not suitable for patients with chest fullness due to qi deficiency, or combined with tonics. "(Rihuazi Ben Cao >): the Chinese herbal medicine has the effects of regulating middle energizer, tonifying five internal organs, descending qi, stopping cholera, vomiting and regurgitation, tonifying deficiency and fatigue, building up body, facilitating urination and defecation, breaking knots, eliminating five septa, relieving cough, moistening heart and chest and eliminating phlegm qi. Descending qi and eliminating phlegm, relieving cough and asthma, moistening the intestines and relaxing bowels. Can be used for treating phlegm stagnation and adverse flow of qi, cough and asthma, and constipation due to intestinal dryness. When the feed containing perilla oil is used for feeding chicken, the plasma cholesterol level of the chicken can be reduced, the feed has an inhibiting effect on proteus, aspergillus niger, penicillium and mould in nature, and the degreased ethanol extract has antiseptic and antioxidant effects.

Dried orange peel: bitter, pungent and warm. It enters lung and spleen meridians. Has the functions of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm. Warm can move qi, pungent can disperse, bitter can drain water. In terms of lung, pungent and dispersing lung qi, bitter and purging lung qi, warming and resolving cold qi, and treating cough and dyspnea with excessive phlegm and qi stagnation; the orange peel with its white inside removed is called Juhong, which is bitter and pungent, so it is mainly used for eliminating dampness and resolving phlegm in clinic, especially for phlegm accumulation in lung, such as Juhong pill. Ju Lu has the actions of moving qi of meridians and collaterals and removing phlegm-dampness from meridians and collaterals, so it is often combined with other prescriptions when clinically used for numbness of limbs due to qi stagnation and phlegm obstruction. The tangerine seed has the functions of resolving masses, relieving pain, eliminating dampness and reducing phlegm, so the tangerine seed is clinically used for treating hernia pain, damp -caused arthralgia and lumbago and the like. Orange leaves are green in color and have the effect of regulating liver qi, so that the orange leaves are often used in the formula when clinically used for hypochondriac pain and chest distress and breast pain. Magnolia officinalis: bitter, pungent and warm in nature; it enters spleen, stomach and large intestine meridians. The functions are as follows: move qi and remove food retention, dry dampness and remove fullness, check adverse rise of qi and relieve dyspnea. Cortex Magnolia officinalis and its volatile oil have bitter taste and taste stimulating effect, and are reflective to promote secretion of saliva and gastric juice and gastrointestinal peristalsis, and have effects of invigorating stomach and promoting digestion. In vitro experiments prove that the magnolia officinalis decoction has antibacterial effects on gram-positive bacteria such as staphylococcus, hemolytic streptococcus, pneumococcus and bordetella pertussis and gram-negative bacteria such as bacillus anthracis, dysentery, typhoid bacillus, paratyphoid bacillus, vibrio cholerae, escherichia coli, proteus and bacillus subtilis. It has antibacterial effect on Staphylococcus albus and Bacillus subtilis.

White mustard seed: pungent, warm and non-toxic. Enters the meridians of liver, spleen, lung, stomach, heart and uterus. Rihuazi Bencao: for wind-toxin swelling and paralysis, vinegar is ground into Fu. The paste is applied after blood stasis is removed, lumbago and kidney cold are removed, ginger is ground and slightly warmed. Heart pain is caused by drinking wine and vinegar. "compendium of materia Medica": sinapis Albae can enter lung and warm and disperse, so it has the actions of benefiting qi and eliminating phlegm, warming spleen and stomach and promoting appetite, relieving pain and swelling, and removing nausea. It has the functions of cooling air, calming five internal organs, expelling phlegm from diaphragm, eliminating phlegm, eliminating malaria, relieving asthma, promoting resuscitation and improving eyesight, and removing blood stasis and relieving pain. It can dissipate energy and descend, can tonify energy and ascend, and help tonics, especially excel in recovering work. Mustard powder is used as a flavoring agent to increase salivary secretion and amylase activity and reduce heart volume and heart rate.

Balloon flower: bitter in taste, pungent and neutral in nature. It enters lung meridian. Has effects in dispersing lung qi, eliminating phlegm, relieving sore throat, expelling pus, benefiting viscera, invigorating qi and blood, and nourishing qi. Can be used for treating cough with excessive phlegm, sore throat, lung abscess, purulent vomiting, chest fullness, hypochondriac pain, dysentery, abdominal pain, aphtha of the mouth and tongue, conjunctival congestion, swelling and pain, and dysuria. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation. The book Jing (Ben) is characterized in that: "mainly treat chest and hypochondriac pain such as knife prick, abdominal fullness, borygmus and claustrophobia, and palpitations and palpitation". Rihuazi materia Medica (Rihuazi materia Medica) is recorded as follows: 'the next qi can stop cholera and twitch, distending pain in the heart and abdomen, tonify five consumptions, nourish qi, eliminate pathogenic factors and keep warm, tonify deficiency and eliminate phlegm, break symptoms, nourish blood and discharge pus, tonify internal leakage and pharyngitis'. Modern pharmacological research shows that the platycodon root has the effects of eliminating phlegm and relieving cough; reducing blood sugar; inhibiting gastric secretion and resisting ulcer; anti-inflammatory effects; tranquilizing, analgesic and antipyretic effects.

Xianetian ointment: sweet in taste; and (4) temperature. It enters spleen meridian. The functional indications are as follows: strengthening the spleen and stomach; replenishing qi and blood; moisten dryness and resolve phlegm. The principal deficiency is thin; stroke is partially abolished; phlegm-fluid retention and mass retention; skin with phlegm nodule.

White gourd seeds: light smell, slightly sweet taste. For cough due to phlegm-heat, lung abscess, intestinal abscess, gonorrhea, edema, beriberi and hemorrhoid, Zha nose and face liquor is prepared. The Chinese waxgourd seed is extracted with water and dialyzed to obtain dialyzate as the mitogen for B cell, which has the activity of clone B cell activator and adjuvant activity, and can increase the number of plaque-forming cells and promote immunity. 4 components are separated and purified from the waxgourd seeds, and the waxgourd seed extract has the function of inhibiting the activity of trypsin.

Perilla leaf: warm in nature and pungent in flavor, and has the effects of relieving exterior syndrome, dispelling cold, regulating qi-flowing and harmonizing ying. Is suitable for treating common cold, fever, cough, asthma, and abdominal distention. The whole plant of perilla has high nutritive value, low sugar, high fiber, high carotene, high mineral elements, etc. The volatile oil contains perillaldehyde, perillyl alcohol, menthone, menthol, eugenol, and threenone. The content of the antisenilide SOD in per milligram of folium Perillae is up to 106.2 micrograms. The research shows that each part of the perilla has good anticancer effect, particularly the effect in the leaves is stronger, and the oleanolic acid is a strong natural anticancer agent, has the effect of preventing tumors, and has the effects of diminishing inflammation, calming, strengthening the heart, promoting urination, enhancing the immunity, reducing the blood fat and resisting the growth of cancer cells. The perilla can sweat and dispel cold to relieve exterior pathogens, can promote qi circulation to relieve epigastric distention, relieve depression and arrest vomiting, so the perilla is suitable for treating wind-cold exterior syndrome with chest distress and vomiting symptoms; or the symptoms of qi stagnation without exterior symptoms, and can also be used for dredging.

And 3, cacumen Tamaricis: sweet, pungent and neutral. It enters heart, lung and stomach meridians. The functional indications are as follows: disperse wind, relieve exterior syndrome, promote eruption. Can be used for treating measles without adequate eruption and rheumatalgia.

Almond: bitter and slightly warm; has little toxicity. The miscellaneous records of famous physicians: apricot kernel, collected in May. The two kernels kill people and can poison dogs. Raw jin shan chuang gu. "Shen nong Ben Cao Jing: "cough with adverse rise of qi, thunder and ringing, throat impediment, descending of qi, breast-producing golden sore, and cold heart rushing to a pig". "treatise on drug Property: it is indicated for abdominal obstruction, sweating and warm diseases. Treating heart-downward urgency, fullness and pain, relieving heart-abdominal vexation, and treating cough due to lung-qi, dyspnea with rapid and short breath. Decoct radix asparagi to moisten the heart and lung. Can be used as soup with cheese to nourish and moisten voice. The cold air is cooled immediately. To relieve cough and dyspnea, moisten intestines to relieve constipation. The book Ben Cao Jing Ji Zhu: "get good fire. Astragalus root, scutellaria root, pueraria root. Is specially named as Zingiber mioga. Bitter apricot kernel, semen Armeniacae amarum, with the effects of warming lung and relaxing bowel, is only suitable for excess syndromes such as wind pathogen and intestinal dryness. For yin deficiency and stagnated fire, it should not be taken orally for a long time. Such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegm, and the like, are forbidden to be taken by single medicine for a long time. The almond is eaten correctly, so that the effects of promoting the production of body fluid to quench thirst, moistening the lung to relieve asthma, lubricating the intestines to relieve constipation and reducing intestinal cancer can be achieved.

And (3) inula flower: salty, warm, slightly toxic; enter lung, liver and stomach meridians. It has the actions of resolving phlegm, descending qi, softening hard masses and promoting the flow of water. The book Jing: "predominate qi accumulation, hypochondriac fullness and palpitations. Remove water, remove cold and heat in the five zang organs, tonify the middle-jiao and descend qi. "treatise on drug Property: mainly governing hypochondriac qi, and treating edema due to cold and heat in the lower part, mainly treating bladder retention, removing the large abdomen, stimulating the appetite, and stopping vomiting without eating in the adverse direction. It is used to treat phlegm accumulation in chest, fullness in hypochondrium, cough and asthma, singultus, saliva such as resina gargarizans, epigastric fullness , belching, and edema of large abdomen. Chlorogenic acid has sensitization effect on human, and when dust of plant containing chlorogenic acid is inhaled (such as in coffee maker), asthma and dermatitis can occur, but after ingestion, the dust can be changed into non-allergenic substances through the action of small intestine secretion, so that the allergen is preferably tested by intradermal method rather than oral method. Supplement to the Yanyi of Ben Cao (supplement to the Yan Yi of materia Medica): it should not be taken for patients with asthenia, and is good for large intestine. "

White anterior: pungent, bitter and slightly warm; it enters lung meridian. The book Tang Ben Cao (herbal of Tang Dynasty): "Baiqiang, leaves like willow or lilac daphne flower bud, Miao Gao Ching, Shengzhou Gutilao. White root, better than Xixin, and sweet in flavor. It is usually drunk in wine and mainly ascends qi. It is not in the near future. The one with sprawl in the past is bitter in flavor and not genuine. ". original source of origin: bai Qian is slightly warmer than Bai Wei and slightly more neutral than Xi xi. It is indicated for apoplexy due to lung obstruction, not for salty cold of Bai Wei, but for dryness-heat of lung and stomach, it is not like pungent-flowing of Xixin, so it is indicated for sinking cold of kidney and liver. Direct qi downward and resolve phlegm, stop cough. Cough with profuse sputum, asthma. It is slightly warm but not dry, so it is good at dispelling phlegm and directing lung qi downward to relieve cough and dyspnea. It is indicated for cold and heat, external contraction and internal injury, new cough and chronic cough.

Chrysanthemum of the lower county: bitter and cold. The functional indications are as follows: clear heat and promote diuresis, remove toxicity and relieve swelling. Can be used for treating common cold, hyperpyrexia, bronchitis, pharyngolaryngitis, tonsillitis, and icterohepatitis; it is externally used for carbuncle, furuncle, sore and ulcer, and snake bite.

Eucalyptus tenuifolius: pungent, slightly bitter and warm. The functional indications are as follows: diminishing inflammation, sterilizing, eliminating phlegm, relieving cough, astringing and killing parasite. Can be used for preventing influenza and Japanese encephalitis. Can be used for preventing and treating malaria, enteritis, diarrhea, dysentery, skin ulcer, carbuncle, sore, red swelling, erysipelas, mastitis, wound infection, tinea, and neurodermatitis. It can also be used for treating leptospirosis, tracheitis, cough, maggot, and mosquito.

Centipeda minima: it has effects in expelling pathogenic wind and cold, relieving nasal obstruction, relieving cough, removing toxic materials, and relieving itching. The book materia medica summary of the invention cloud: shihutuo, Jiu Qiao, also can be used for relieving stuffy nose. Its flavor is pungent and drastic, its qi is pungent and smoked, its property is ascending and dispersing, it can dredge the lung channel, go up to the head, so it mainly means snore clam phlegm dyspnea, dyspnea and obstruction, nasal obstruction and nasal hemorrhoid, swelling and stuffiness are unfavorable, remove nebula in eyes, and cold pathogen in head, wind and brain pain, all get the pungent and ascending and dispersing function. Cough and asthma relieving effects: the volatile oil and ethanol extractive solution have antitussive, expectorant, and antiasthmatic effects. The volatile oil and ethanol extractive solution have some effects of relieving cough, eliminating phlegm, and relieving asthma, and the precipitate has no significant effect of relieving cough and eliminating phlegm. In vitro experiments show that the decoction has an inhibitory effect on mycobacterium tuberculosis. The whole herb extract has obvious inhibition effect on beta-hydroxy-beta-methylglutaric acid (HMG) coenzyme A, calcium channel blocker and cholecystokinin.

A Tai mushroom: slightly salty, warm. The functional indications are as follows: catch wind, dispel cold, relax tendons and activate collaterals. Can be used for treating lumbago, skelalgia, numbness of limbs, and discomfort of tendons and collaterals.

Watermelon peel: sweet, bland and cold. Enter heart and stomach meridians. The main functions are clearing away heat and relieving summer-heat, purging heat and relieving restlessness and promoting urination. Can be used for treating summer heat, polydipsia, scanty and brownish urine, sore throat, aphtha of the mouth and tongue, edema, etc.

Herba schizonepetae: pungent, slightly bitter and slightly damp in nature; enter lung and liver meridians. Rihuazi Bencao: benefiting the five internal organs, promoting digestion, descending qi and sobering up. As dish, the tea is decocted to treat the wind of head and sweating; the fermented soybean juice is decocted for treating sudden typhoid fever. "compendium" (compendium): to disperse wind-heat, clear head and eyes, relieve sore throat and eliminate sores and swelling. It is indicated for stiff neck, blackish flower in eyes, sores, lingering blood, hematemesis, epistaxis, bleeding, bloody dysentery, metrorrhagia, and hemorrhoids and fistula. The main symptoms are cold fever, headache, eye itching, cough, swollen and sore throat, measles, carbuncle and swelling, scabies and postpartum anemic fainting. Can be used for treating common cold, headache, measles, rubella, and initial stage of pyocutaneous disease. Stir-baked into charcoal is indicated for hematochezia, metrorrhagia and metrostaxis and postpartum anemic fainting. The herba Schizonepetae decoction has strong antibacterial effect on Staphylococcus aureus and Bacillus diphtheriae. The typhoid mixed vaccine is used for heating the rabbits, and schizonepeta decoction or ethanol infusion is added for 2g/kg intragastric administration, so that weak antipyretic effect is found. The schizonepeta oil can lower the body temperature of normal rats; it also has sedative effect, and the action of catnip oil (0.5 ml/kg) is reduced when the stomach is irrigated to rabbits, and the muscles of limbs are slightly relaxed. The catmint oil can obviously prolong the incubation period of acetylcholine and histamine mixed liquor to guinea pigs to cause asthma, and reduce the number of animals generating convulsion; can also resist acetylcholine or histamine induced contraction of guinea pig airway smooth muscle; it also has the action of eliminating phlegm.

Parsley: sweet in taste; the nature is mild. The functional indications are as follows: dispelling pathogenic wind and relieving pain; reducing blood pressure. Treating common cold; headache; hypertension.

Wind prevention: pungent, sweet and slightly warm in nature; enter bladder meridian, lung meridian, spleen meridian and liver meridian. Rihuazi Bencao: for curing wind-heat of thirty-six directions, all the male consumptive diseases are inferior, the middle-jiao is tonified, the spirit is benefited, the wind is red, the tear is stopped, the paralysis is slow, the five internal organs are cleared, the guan pulse is relieved, the five internal diseases are damaged, the night sweat is weakened, the vexation and the body weight are weakened, the spirit is calmed, and the qi pulse is homogenized. "Changsha Yao Jie" (Changsha Yao Jie solution): activating meridians, expelling dampness, dredging joints, relieving pain, relaxing tendons and vessels, stretching spasm, activating limbs and joints, treating paralysis, arresting spontaneous perspiration, night sweat, and metrorrhagia. It has the functions of dispelling wind, relieving exterior syndrome, eliminating dampness, relieving pain, relieving spasm and relieving itching. Can be used for treating wind cold, headache, body pain, rheumatalgia, joint pain, abdominal pain, diarrhea, enteropathogenic wind, tetanus, rubella pruritus, and initial pyocutaneous disease. It is contraindicated for patients with yin and blood deficiency and febrile disease with stirring wind, and contraindicated for patients with spasm due to blood deficiency or headache due to wind pathogen.

Licorice root: sweet in nature and taste and mild in nature. Enter spleen, stomach and lung meridians. The book Jing (Ben) is characterized in that: the five internal organs and six external organs are mainly controlled by cold and heat pathogenic factors, the muscles and bones are strengthened, the muscles are grown, the strength is high, the golden sore is swollen, and the toxicity is removed. Human yin (not) treatise on drug properties, is recorded as: the medicine is mainly used for treating cold pain in the abdomen, treating fright epilepsy and eliminating abdominal distension; tonifying the five internal organs; preparing various medicine toxins; nourishing kidney qi and internal injury, and treating flaccidity; lumbago due to blood drop of housewife; deficiency with excessive heat; it is used in addition. Has effects in invigorating qi, strengthening middle warmer, relieving pain, moistening lung, relieving cough, clearing pathogenic fire, removing toxic substances, and harmonizing the drugs. It is mainly manifested as lassitude, poor appetite, emaciation, sallow complexion, palpitation, shortness of breath, abdominal pain, loose stool, spasm and pain of limbs, irritability, cough, asthma, sore throat, carbuncle, sore and swelling, infantile carbuncle, and drug and food poisoning. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature. The pharmacological discovery of western medicine shows that the licorice preparation has the functions of anti-inflammation and anti-allergy reflection, so the licorice preparation is mainly used as a demulcent in the clinical practice of western medicine. Relieving cough, eliminating phlegm, and treating pharyngalgia and laryngitis; the liquorice or glycyrrhetinic acid has the effect of the deoxycorticosterone and has good effect on the chronic adrenocortical insufficiency; the Glycyrrhrizae radix preparation has effects in promoting stomach mucus formation and secretion, prolonging epithelial cell life, and resisting inflammation, and can be used for treating chronic ulcer and duodenal ulcer; the flavone of Glycyrrhrizae radix has antiinflammatory, spasmolytic and antacid effects; licorice root is also one of the main raw materials of Rendan.

And (3) le Ma Hui: bitter and cold. The functional indications are as follows: clear lung-heat, resolve phlegm, relieve cough and remove toxicity. Can be used for treating chronic tracheitis, lung suppuration, cough with purulent blood; it is used externally to treat piles, eczema, rubella, furuncle, carbuncle, sore and ulcer.

New Zealand spinach: sweet; slightly pungent; the nature is mild. Entering the lung; liver; the large intestine channel. The functional indications are as follows: dispelling wind and clearing heat; detoxify and detumescence. Blood-shot eyes due to wind-heat; treating sore and swelling pain; enteritis; sepsis; a tumor.

Chinese yam: sweet in taste and neutral in nature, entering lung, spleen and kidney meridians; it has effects in invigorating spleen, tonifying lung, invigorating stomach, tonifying kidney, strengthening kidney, replenishing essence, improving hearing and eyesight, strengthening muscle and bone, tranquilizing mind, and prolonging life; it can be used for treating weakness of spleen and stomach, asthenia, anorexia, chronic diarrhea, dysentery, dryness of lung-qi, phlegm asthma, cough, deficiency of kidney-qi, soreness of waist and knees, asthenia, thirst, frequent micturition, spermatorrhea, premature ejaculation, leukorrhagia, red swelling of skin, and obesity. The compendium of materia medica summarizes the five major functions of tonifying kidney qi, strengthening spleen and stomach, stopping diarrhea, resolving phlegm and saliva, moistening skin. The rhizoma Dioscoreae porridge can be cooked with crystal sugar and administered for treating chronic diseases such as poor health, colitis, and kidney deficiency. Tonifying the spleen and stomach: can be used for treating weakness of spleen and stomach, diarrhea, tiredness, anorexia, and sweating due to asthenia. Benefiting lung and nourishing kidney: it is neither cold nor dry, and sweet in taste and moist in nature, and can be used for treating consumptive thirst, spermatorrhea, leukorrhagia, etc. due to lung and kidney deficiency. Is known as Shenxian medicine.

Ganoderma lucidum: the nature is sweet and neutral. It enters heart, lung, liver and kidney meridians. It can be used for treating consumptive disease, cough, asthma, insomnia, dyspepsia, and malignant tumor. Animal pharmacology shows that the experiment: ganoderma has effects of inhibiting nervous system, lowering blood pressure and enhancing heart contraction, eliminating phlegm, protecting liver, enhancing immunity, and resisting bacteria.

Hawthorn fruit: the hawthorn is a common product for treating dyspepsia, can increase the secretion of gastric digestive enzymes and promote digestion; has obvious inhibiting effect on dysentery bacillus, pseudomonas aeruginosa, staphylococcus aureus, etc.

The feed additive is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of pinellia ternata, 15-25 parts of poria cocos, 10-23 parts of ginger, 10-20 parts of gleditsia sinensis lam, 10-18 parts of perilla fruit, 20-30 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 10-20 parts of semen brassicae, 10-19 parts of platycodon grandiflorum, 10-18 parts of cyanea extract, 10-20 parts of semen benincasae, 10-21 parts of perilla leaf, 10-20 parts of cacumen tamaricis, 10-20 parts of almond, 10-20 parts of inula flower, 10-18 parts of cynanchum glaucescens, 10-30 parts of chrysanthemum indicum, 10-25 parts of eucalyptus leptostachya, 10-20 parts of centipeda minima, 10-20 parts of matsutake, 10-19 parts of exocarpium citrulli, 10-24 parts of schizonepeta tenuifolia, 10-19 parts of jerusal pars, 10-20 parts of divaricate saposhnikovia root and 10-30 parts of liquorice.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 13-16 parts of pinellia ternata, 19-23 parts of poria cocos, 14-21 parts of ginger, 12-17 parts of gleditsia sinensis, 12-15 parts of perilla fruit, 23-28 parts of dried orange peel, 15-25 parts of mangnolia officinalis, 12-16 parts of semen brassicae, 13-19 parts of platycodon grandiflorum, 10-15 parts of cyanea extract, 14-20 parts of semen benincasae, 14-19 parts of perilla leaf, 12-18 parts of cacumen tamaricis, 13-17 parts of almond, 13-20 parts of inula flower, 13-18 parts of cynanchum glaucescens, 16-25 parts of chrysanthemum indicum, 13-21 parts of eucalyptus leptostachya, 13-20 parts of centipeda minima, 10-16 parts of matsutake, 10-14 parts of watermelon peel, 14-20 parts of schizonepeta, 13-19 parts of parsley, 13-19 parts of rhizoma pinelliae, rhizoma pinelliae, 13-18 parts of divaricate saposhnikovia root and 15-23 parts of liquorice.

The feed additive can also be prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 21 parts of poria cocos, 17 parts of ginger, 14 parts of honey locust, 14 parts of perillaseed, 25 parts of dried orange peel, 20 parts of mangnolia officinalis, 14 parts of white mustard seed, 16 parts of platycodon grandiflorum, 13 parts of cyanea, 16 parts of waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen tamaricis, 15 parts of almond, 17 parts of inula flower, 14 parts of cynanchum glaucescens, 21 parts of aster ageratoides, 16 parts of eucalyptus tenuifolia, 17 parts of centipeda minima, 13 parts of matsutake, 12 parts of watermelon peel, 17 parts of schizonepeta, 16 parts of parsley, 15 parts of divaricate saposhnikovia root and 17 parts of liquorice.

The feed additive preferably further comprises: herba Lespedezae Cuneatae, herba Tetragoniae Yunnanensis, rhizoma Dioscoreae, Ganoderma and fructus crataegi.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 10-20 parts of pinellia ternata, 15-25 parts of poria cocos, 10-23 parts of ginger, 10-20 parts of gleditsia sinensis lam, 10-18 parts of perilla fruit, 20-30 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 10-20 parts of semen brassicae, 10-19 parts of platycodon grandiflorum, 10-18 parts of cyanea extract, 10-20 parts of semen benincasae, 10-21 parts of perilla leaf, 10-20 parts of cacumen tamaricis, 10-20 parts of almond, 10-20 parts of inula flower, 10-18 parts of cynanchum glaucescens, 10-30 parts of chrysanthemum indicum, 10-25 parts of eucalyptus leptostachya, 10-20 parts of centipeda minima, 10-20 parts of matsutake, 10-19 parts of exocarpium citrulli, 10-24 parts of schizonepeta tenuifolia, 10-19 parts of jerusal pars, 10-20 parts of divaricate saposhnikovia root, 10-30 parts of liquorice, 10-20 parts of herba lespedezae, 10-20 parts of tetragonia, 15-25 parts of Chinese yam, 15-30 parts of lucid ganoderma and 10-15 parts of hawthorn.

The feed additive is preferably prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 20 parts of poria cocos, 17 parts of ginger, 15 parts of gleditsia sinensis, 14 parts of perillaseed, 25 parts of dried orange peel, 18 parts of mangnolia officinalis, 15 parts of white mustard seed, 14 parts of platycodon grandiflorum, 14 parts of nephelinum paste, 15 parts of Chinese waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen cheiraeae, 15 parts of almond, 15 parts of inula flower, 14 parts of cynanchum glaucescens, 20 parts of chrysanthemum indicum, 17 parts of eucalyptus tenuifolia, 15 parts of centipeda minima, 15 parts of typhonium giganteum, 14 parts of watermelon peel, 17 parts of schizonepeta, 14 parts of parsley, 15 parts of divaricate saposhnikovia root, 20 parts of liquorice, 15 parts of herba lemanensis, 15 parts of armeniaca amara, 21 parts of Chinese yam, 21 parts of ganoderma lucidum and 12 parts of hawthorn.

The preparation method comprises the following steps:

step one, putting all raw material medicines into a stirrer according to a certain proportion, stirring and mixing, then sending into a grinder for grinding, putting the ground traditional Chinese medicine composition into a multifunctional extraction tank, adding water which is 5 ~ 7 times of the mass of the traditional Chinese medicine composition, boiling for 2 ~ 4 hours, treating under the steam pressure of 0.6 ~ 1Mpa, and filtering to obtain a first filtrate and filter residue;

step two, adding water which is 5 ~ 7 times of the obtained filter residue into the obtained filter residue again, boiling for 2 ~ 4 hours, treating the filter residue under the steam pressure of 0.6Mpa ~ 1Mpa, and filtering to obtain a second filtrate and the filter residue;

and step three, combining the first filtrate and the second filtrate, concentrating to remove water to obtain dry paste, crushing by using an ultra-fine powder mill to obtain feed additive powder, wherein the powder is crushed to be less than 30 mu m.

Example 1 feed additive 1

The embodiment of the invention provides a feed additive for chicks, which is prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 21 parts of poria cocos, 17 parts of ginger, 14 parts of honey locust, 14 parts of perillaseed, 25 parts of dried orange peel, 20 parts of mangnolia officinalis, 14 parts of white mustard seed, 16 parts of platycodon grandiflorum, 13 parts of cyanea, 16 parts of waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen tamaricis, 15 parts of almond, 17 parts of inula flower, 14 parts of cynanchum glaucescens, 21 parts of aster ageratoides, 16 parts of eucalyptus tenuifolia, 17 parts of centipeda minima, 13 parts of matsutake, 12 parts of watermelon peel, 17 parts of schizonepeta, 16 parts of parsley, 15 parts of divaricate saposhnikovia root and 17 parts of liquorice.

The preparation method comprises the following steps:

step one, putting all raw material medicines into a stirrer according to a certain proportion, stirring and mixing, then sending into a crusher for crushing, putting the crushed traditional Chinese medicine composition into a multifunctional extraction tank, adding water with the amount of 6 times of the mass of the composition, boiling for 3 hours under the steam pressure of 0.8Mpa, and filtering to obtain a first filtrate and filter residue;

secondly, adding the obtained filter residue into water with the mass being 6 times of that of the filter residue, boiling for 3 hours, treating the filter residue under the steam pressure of 0.8Mpa, and filtering to obtain second filtrate and filter residue;

and step three, combining the first filtrate and the second filtrate, concentrating to remove water to obtain dry paste, crushing by using an ultra-fine powder mill to obtain feed additive powder, wherein the powder is crushed to be less than 30 mu m.

Example 2 feed additive 2

The embodiment of the invention provides a feed additive for chicks, which is prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 20 parts of poria cocos, 17 parts of ginger, 15 parts of gleditsia sinensis, 14 parts of perillaseed, 25 parts of dried orange peel, 18 parts of mangnolia officinalis, 15 parts of white mustard seed, 14 parts of platycodon grandiflorum, 14 parts of nephelinum paste, 15 parts of Chinese waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen cheiraeae, 15 parts of almond, 15 parts of inula flower, 14 parts of cynanchum glaucescens, 20 parts of chrysanthemum indicum, 17 parts of eucalyptus tenuifolia, 15 parts of centipeda minima, 15 parts of typhonium giganteum, 14 parts of watermelon peel, 17 parts of schizonepeta, 14 parts of parsley, 15 parts of divaricate saposhnikovia root, 20 parts of liquorice, 15 parts of herba lemanensis, 15 parts of armeniaca amara, 21 parts of Chinese yam, 21 parts of ganoderma lucidum and 12 parts of hawthorn.

The preparation method comprises the following steps:

step one, putting all raw material medicines into a stirrer according to a certain proportion, stirring and mixing, then sending into a crusher for crushing, putting the crushed traditional Chinese medicine composition into a multifunctional extraction tank, adding water with the amount of 6 times of the mass of the composition, boiling for 3 hours under the steam pressure of 0.8Mpa, and filtering to obtain a first filtrate and filter residue;

secondly, adding the obtained filter residue into water with the mass being 6 times of that of the filter residue, boiling for 3 hours, treating the filter residue under the steam pressure of 0.8Mpa, and filtering to obtain second filtrate and filter residue;

and step three, combining the first filtrate and the second filtrate, concentrating to remove water to obtain dry paste, crushing by using an ultra-fine powder mill to obtain feed additive powder, wherein the powder is crushed to be less than 30 mu m.

Toxicity test

1. Cumulative toxicity test report

The feed additive of the invention in example 1 is used as a target, the dosage design is one period every 5 days, the dosage of each period is 0.10LD50, 0.15LD50, 0.22LD50, 0.34LD 50 and 0.50LD50, and the LD50 of the female and male mice of the sample is 5000m parts/k parts of BW (five dosages are 500, 750, 1100, 1700 and 2500m parts/k parts of BW). The weight of the composition is weighed once every 5 days, the dosage is adjusted, and the composition is orally gavaged according to the ratio of 0.1ml/10 parts BW. After 20 days, no mortality occurred in the animals, and at the end of the test, no mortality occurred in both female and male animals after 20 days of increasing dose administration to the subjects. The toxicity test was carried out in the same manner as described above with respect to the feed additive of example 2, and the results were the same as in example 1.

2. Acute toxicity test

An acute toxicity test is carried out by using 40 NIH mice, the SPF level, the weight of each half of a male mouse and a female mouse and the weight of 16-20 g. Mice were randomly divided into two groups of 20 mice each, control and dosing groups, fasted for 12 hours prior to the experiment; the feed additive prepared in example 1 of the present invention was dissolved in water (concentration of 6.58g crude drug/ml, highest concentration) and gavage was performed with a gavage volume of 5ml/kg (i.e., single administration dose of 32.9 crude drug/kg), the control group was administered with an equal amount of physiological saline 2 times a day with an interval of 6 hours, and after administration, the administration was continuously observed for 14 days, and the toxic reaction and death number of mice were recorded. The experimental results show that: compared with a control group, the mice have no obvious difference after administration, and the mice have normal general conditions, diet, drinking water and weight increase after continuous observation for 14 days in the experiment. Therefore, the feed additive disclosed by the embodiment 1 of the invention is low in acute toxicity and safe in clinical medication. The toxicity test was carried out in the same manner as described above with respect to the feed additive of example 2, and the results were the same as in example 1.

Comparative test

In 12 months in 2012, 1500 AA broilers at 21 days old bred by a special chicken-raising household in Taian City, Shandong were attacked, nearly one third of the chickens in two days of attack initially flowed nose, sneezed and had foam secretion in eyes, and then one or two days of whole chickens had cough, dyspnea, snore in trachea, and obviously reduced feed intake, poor spirit, unwilling to walk, and fear of cold and piling. Pathological dissection: mucus is in nasal cavity and trachea, air sac is thickened obviously, eyes are swollen, and gray yellow clot can be extruded. The cough and asthma of wind-cold type can be diagnosed according to the symptoms and pathological changes of the affected chicken.

600 sick chickens were selected and randomized into three groups, example group 1, example group 2 and control group. Example group 1 a conventional feed supplemented with the feed additive of example 1 of the present invention was used, the feed additive accounting for 5% of the total weight of the feed, for 3-5 days; example group 2 a conventional feed supplemented with the feed additive of example 2 of the present invention was used, the feed additive accounting for 7% of the total weight of the feed, for 3-5 days; the control group is treated by enrofloxacin and jingshhuba powder, wherein 55g of enrofloxacin and 40g of jingshhuba powder are added into each 1kg of feed for 3-5 days. The test is 21 days, the disease is treated according to the symptom improvement condition of different chickens, and after the total treatment is carried out for 5 days, the cure rate, the effective rate, the ineffective rate and the death rate of the sick chickens are counted. The results of the experiment are shown in tables 1 and 2.

Treatment criteria were: all symptoms disappear, and the appetite and spirit return to normal, so that the disease is cured; the cough relieving tea has the advantages of smooth breathing, unobvious snore in the trachea, obviously improved cough and asthma symptoms, basically recovered appetite and spirit, and effectiveness; all symptoms were unchanged, even dead, and were not effective; wherein the effective rate is the percentage of the sum of healing and effective rates in the total number.

Table 1 effect after 5 days of total treatment is shown in% by comparison

Group of	Total number of	Recovery method	Is effective	Invalidation	High efficiency	Mortality rate
							Example set 1	200	153	39	8	96%	2%
Example group 2	200	162	32	6	97%	1.5%
							Control group	200	129	25	46	77%	11.5%

TABLE 2 recovery and effective chicken in 5 days of treatment and time comparison of each experimental group%

Group of	Healing and effective sum	Day 1	Day 3	Day 5
					Example set 1	182	37（20.3%）	124（68.1%）	21（11.5%）
Example group 2	194	42（21.6%）	134（69.1%）	18（9.3%）
					Control group	154	18（11.7%）	87（56.5%）	49（31.8%）

From the data in tables 1 and 2, it can be seen that: the feed additive has the advantages of quick response, high effective rate, definite curative effect, high safety and no toxic or side effect; after five days of treatment, the feed additive is continuously used for treating the effective chickens for 1 to 3 days, the effective chickens of the example group 1 and the example group 2 are all cured, and the chickens cured by the example group 1 and the example group 2 are observed continuously for a few days later, so that the feed intake of the chickens cured is higher than that of the chickens in the control group; after the experiment is finished, the chickens are fed in groups until the chickens are out of the column at the age of 42 days, and the results are counted, wherein the recurrence rates of the chickens cured within five days in example group 1 and example group 2 are respectively as follows: 6.5% and 5.0%, while the rate of relapse was 36.4% in the control group of chickens cured within five days.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (2)

1. The feed additive for the chicks is characterized by being prepared from the following raw medicinal materials in parts by weight: 10-20 parts of pinellia ternata, 15-25 parts of poria cocos, 10-23 parts of ginger, 10-20 parts of gleditsia sinensis lam, 10-18 parts of perilla fruit, 20-30 parts of dried orange peel, 10-25 parts of mangnolia officinalis, 10-20 parts of semen brassicae, 10-19 parts of platycodon grandiflorum, 10-18 parts of cyanea extract, 10-20 parts of semen benincasae, 10-21 parts of perilla leaf, 10-20 parts of cacumen tamaricis, 10-20 parts of almond, 10-20 parts of inula flower, 10-18 parts of cynanchum glaucescens, 10-30 parts of chrysanthemum indicum, 10-25 parts of eucalyptus leptostachya, 10-20 parts of centipeda minima, 10-20 parts of matsutake, 10-19 parts of exocarpium citrulli, 10-24 parts of schizonepeta tenuifolia, 10-19 parts of jerusal pars, 10-20 parts of divaricate saposhnikovia root, 10-30 parts of liquorice, 10-20 parts of herba lespedezae, 10-20 parts of tetragonia, 15-25 parts of Chinese yam, 15-30 parts of lucid ganoderma and 10-15 parts of hawthorn;

the preparation method of the feed additive comprises the following steps:

step one, putting all raw material medicines into a stirrer according to a certain proportion, stirring and mixing, then sending into a grinder for grinding, putting the ground traditional Chinese medicine composition into a multifunctional extraction tank, adding water which is 5 ~ 7 times of the mass of the traditional Chinese medicine composition, boiling for 2 ~ 4 hours, treating under the steam pressure of 0.6 ~ 1Mpa, and filtering to obtain a first filtrate and filter residue;

step two, adding water which is 5 ~ 7 times of the obtained filter residue into the obtained filter residue again, boiling for 2 ~ 4 hours, treating the filter residue under the steam pressure of 0.6Mpa ~ 1Mpa, and filtering to obtain a second filtrate and the filter residue;

and step three, combining the first filtrate and the second filtrate, concentrating to remove water to obtain dry paste, crushing by using an ultra-fine powder mill to obtain feed additive powder, wherein the powder is crushed to be less than 30 mu m.

2. The chick feed additive according to claim 1, wherein the chick feed additive is prepared from the following raw medicinal materials in parts by weight: 15 parts of pinellia ternate, 20 parts of poria cocos, 17 parts of ginger, 15 parts of gleditsia sinensis, 14 parts of perillaseed, 25 parts of dried orange peel, 18 parts of mangnolia officinalis, 15 parts of white mustard seed, 14 parts of platycodon grandiflorum, 14 parts of nephelinum paste, 15 parts of Chinese waxgourd seed, 16 parts of perilla leaf, 15 parts of cacumen cheiraeae, 15 parts of almond, 15 parts of inula flower, 14 parts of cynanchum glaucescens, 20 parts of chrysanthemum indicum, 17 parts of eucalyptus tenuifolia, 15 parts of centipeda minima, 15 parts of typhonium giganteum, 14 parts of watermelon peel, 17 parts of schizonepeta, 14 parts of parsley, 15 parts of divaricate saposhnikovia root, 20 parts of liquorice, 15 parts of herba lemanensis, 15 parts of armeniaca amara, 21 parts of Chinese yam, 21 parts of ganoderma lucidum and 12 parts of hawthorn.