CN105687788A - Pharmaceutical composition capable of softening blood vessels and application thereof - Google Patents

Abstract

A pharmaceutical composition for softening blood vessels. The raw materials of the pharmaceutical composition are composed of mountain plant leaves, salvia miltiorrhiza, scorpion, pangolin, achyranthes bidentata, notopterygium, Atractylodes macrocephala, Tribulus terrestris, Panax notoginseng, capillary, Morus alba, chicken Composition of blood vine, uncaria, safflower, fragrant chrysanthemum, poria cocos, snow lotus, Eucommia leaves, angelica, chuanxiong, tangerine peel, knotweed, earthworm, purslane, ginkgo leaves, kudzu root, cassia seed, hawthorn, gastrodia elata. The compatibility of the pharmaceutical composition is in line with the principle of "junchenzuoshi" of traditional Chinese medicine, with prominent focus, comprehensive and reasonable. Oral medicine can regulate viscera function, reduce blood fat, soften blood vessels, make blood thin, increase blood flow vitality, and soften blood vessels. The effect is obvious, and the raw material Rich, simple preparation process, no toxic and side effects, low price, and good application prospects in softening blood vessels, treating and preventing "three highs", especially hyperlipidemia.

Description

A pharmaceutical composition for softening blood vessels and its application

technical field

The invention belongs to the technical field of medicine and relates to a traditional Chinese medicine composition, in particular to a medicinal composition for softening blood vessels and an application thereof.

Background technique

Due to the increasingly developed economy and the continuous improvement of modern people's living standards, people love to enjoy too much, and do not pay attention to their own lifestyle, behavior habits, and eating habits, which cause diseases. Fast-paced social life and fierce competition work pressure have caused serious threats to the physical and mental health of modern people, coupled with long-term unreasonable diet, that is: refined grains completely replace coarse grains, a large number of three highs (high heat, high protein, High fat), three excess (more preservatives, more flavor enhancers, more hormones) food intake and the accumulation of pesticides and fertilizers in the food residues in the body, coupled with air and water pollution and less exercise, obesity And diabetes has become a disease of the rich and the rich. About what are the three highs According to statistics, among the top ten causes of death in China, the mortality rate related to metabolic diseases is as high as 35.7%, and the number of deaths related to the "three highs" also accounts for 27% of the total death toll. "Three highs" refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia. Hyperlipidemia can cause vascular embolism; high blood pressure can cause cerebral hemorrhage and cerebrovascular rupture; high blood sugar can cause diabetes. Often accompanied by obesity. They are "diseases of wealth" derived from modern society, and they may exist independently or be related to each other. For example, people with diabetes are likely to suffer from high blood pressure or hyperlipidemia at the same time, and hyperlipidemia is the main factor in the formation and development of arteriosclerosis. The poor elasticity of blood vessels in patients with arteriosclerosis aggravates the increase in blood pressure, so the "three highs" are formed in the later stage ". The World Health Organization once clearly stated that the first line of defense to prevent cardiovascular disease is to reduce and control the "three highs". Many diabetics are accompanied by hyperlipidemia, so people usually call diabetes and hyperlipidemia sister diseases, and think that hyperlipidemia is a secondary disease of diabetes. According to statistics, about 40% of diabetic patients have lipid metabolism disorders. It is characterized by increased triglycerides and decreased high-density lipoproteins.

Hyperlipidemia is a systemic disease. A large number of research data show that hyperlipidemia is an independent and important risk factor for stroke, coronary heart disease, myocardial infarction, and sudden cardiac death. In addition, hyperlipidemia is also an important risk factor for hypertension, impaired glucose tolerance, and diabetes. Hyperlipidemia can also lead to fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, fundus hemorrhage, blindness, peripheral vascular disease, claudication, hyperuricemia.

In the past 20 years, people's food consumption and dietary structure have undergone great changes. The most significant effect brought about by this is that the incidence of hyperlipidemia continues to increase, and the age gradually appears younger. Urban white-collar workers have a fast pace of life, high work pressure, irregular diet, and lack of exercise. About 40% of them have hyperlipidemia. According to statistics, the number of patients with hyperlipidemia in my country has reached 160 million. Experts estimate that among adults over the age of 30 in the country, the incidence of hyperlipidemia is about 10%-20%, and the number of patients with hyperlipidemia is as high as 90 million. According to the survey, 2.5 million to 3 million people die of cardiovascular disease in my country every year, and this type of disease has become the main cause of death that endangers the health of urban and rural populations in my country. Speaking of cardiovascular disease, many people know that it is related to high blood pressure, but in fact, there is a hidden and more powerful "killer" hidden in our body that always threatens our blood vessel health, which is hyperlipidemia. Experts pointed out that dyslipidemia is one of the important risk factors for cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction and ischemic stroke.

In recent years, the occurrence of "senile diseases" among young people has increased year by year. Arteriosclerotic cardiovascular and cerebrovascular diseases occur gradually, and are mostly related to unhealthy lifestyles, accumulation of toxins in the body, and environmental pollution that leads to blood viscosity and coagulation. Stress in life and work, smoking, alcoholism, overnutrition, blood viscosity, and abnormalities in the blood Normal ingredients (toxins), etc., seriously exceed the standard, forming arteriosclerosis, vascular inflammation, and early thrombosis. In the middle stage, the blood lesion stage, adolescents and even infants, in the middle stage, vascular disease becomes the blood flow change stage, which can occur in young and middle-aged people. In the late stage, in the stage of organ damage or the failure stage of life (onset stage), the vascular obstruction is severe, and more than 50% lead to cardiovascular and cerebrovascular diseases, and peripheral blood vessels develop and form severe hypertension, and severe cases are life-threatening.

Arteriosclerosis and blood viscosity are the source of all diseases. The resulting arteriosclerosis, hyperviscosity, heart disease, myocardial infarction, cerebral infarction, stroke, hypertension, diabetes, tumors, etc. are gradually increasing. High blood viscosity causes three highs, high blood viscosity causes hyperlipidemia, high blood viscosity causes high blood pressure, and high blood viscosity accelerates diabetes complications. Western medicine is currently unsatisfactory in the treatment of arteriosclerosis and blood viscosity, and the price is high, and it is usually accompanied by serious side effects, which seriously affect the patient's health. Traditional Chinese medicine has unique advantages in the treatment of such chronic diseases due to its small side effects , but there is currently no effective prescription for softening blood vessels.

Contents of the invention

The invention aims at the deficiencies in the prior art, and provides a pharmaceutical composition for softening blood vessels and its application. The pharmaceutical composition has simple process, low cost, no side effects, and has remarkable curative effect in softening blood vessels.

Above-mentioned purpose of the present invention is achieved by following technical scheme:

A pharmaceutical composition for softening blood vessels. The raw materials of the pharmaceutical composition are composed of mountain plant leaves, salvia miltiorrhiza, scorpion, pangolin, achyranthes bidentata, notopterygium, Atractylodes macrocephala, Tribulus terrestris, Panax notoginseng, capillary, Morus alba, chicken Composition of blood vine, uncaria, safflower, fragrant chrysanthemum, poria cocos, snow lotus, Eucommia leaves, angelica, chuanxiong, tangerine peel, knotweed, earthworm, purslane, ginkgo leaves, kudzu root, cassia seed, hawthorn, gastrodia elata.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 12-20 parts of mountain plant leaves, 10-16 parts of scorpion, 3-8 parts of angelica, and 5-12 parts of pangolin , 12-17 parts of Achyranthes bidentata, 7-12 parts of Salvia miltiorrhiza, 4-9 parts of safflower, 15-20 parts of Atractylodes macrocephala, 10-15 parts of Tribulus terrestris, 8-12 parts of capillary, 2-5 parts of mulberry bark, notopterygium 3-7 parts, 11-14 parts of Caulis Spatholobus, 9-15 parts of Uncaria, 3-6 parts of Chuanxiong, 8-13 parts of Fragrant Chrysanthemum, 3-5 parts of Snow Lotus, 1-3 parts of Eucommia Leaf, 5-10 parts of Chenpi 5-10 parts of panax notoginseng, 13-16 parts of knotweed, 3-10 parts of earthworm, 8-13 parts of purslane, 3-5 parts of ginkgo biloba, 1-3 parts of poria cocos, 5-10 parts of kudzu root, cassia seed 3-6 parts, 8-13 parts of Hawthorn, 3-5 parts of Gastrodia elata.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 12 parts of mountain plant leaves, 16 parts of scorpion, 3 parts of angelica, 12 parts of pangolin, 12 parts of Achyranthes bidentata, 10 parts of salvia miltiorrhiza 9 parts of safflower, 15 parts of Atractylodes macrocephala, 15 parts of Tribulus terrestris, 8 parts of capillary, 5 parts of Morus alba, 3 parts of Notopterygium, 14 parts of Caulis Spatholobus, 9 parts of Uncaria, 6 parts of Chuanxiong, 8 parts of Xiangju , 5 parts of snow lotus, 1 part of eucommia leaf, 10 parts of tangerine peel, 5 parts of notoginseng, 16 parts of knotweed, 10 parts of earthworm, 8 parts of purslane, 5 parts of ginkgo leaf, 1 part of poria cocos, 10 parts of kudzu root, 6 parts of cassia seed , 8 parts of Hawthorn, 3 parts of Gastrodia elata.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 20 parts of mountain plant leaves, 10 parts of scorpion, 8 parts of angelica, 5 parts of pangolin, 17 parts of Achyranthes bidentata, 12 parts of salvia miltiorrhiza 4 parts of safflower, 20 parts of Atractylodes macrocephala, 10 parts of Tribulus terrestris, 12 parts of capillary, 2 parts of Morus alba, 7 parts of notopterygium, 11 parts of Caulis Spatholobus, 15 parts of Uncaria, 3 parts of Chuanxiong, 13 parts of fragrant chrysanthemum , 3 parts of snow lotus, 3 parts of Eucommia leaves, 5 parts of tangerine peel, 10 parts of Panax notoginseng, 13 parts of knotweed, 3 parts of earthworm, 13 parts of purslane, 3 parts of ginkgo biloba, 3 parts of poria cocos, 5 parts of kudzu root, 4 parts of cassia seed , Hawthorn 10 parts, Gastrodia elata 4 parts.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 13 parts of mountain plant leaves, 11 parts of scorpion, 4 parts of angelica, 6 parts of pangolin, 13 parts of Achyranthes bidentata, 7 parts of salvia miltiorrhiza 5 parts of safflower, 18 parts of Atractylodes macrocephala, 11 parts of Tribulus terrestris, 9 parts of capillary, 4 parts of Morus alba, 6 parts of notopterygium, 12 parts of Caulis Spatholobus, 13 parts of Uncaria, 4 parts of Chuanxiong, 9 parts of fragrant chrysanthemum , 4 parts of snow lotus, 2 parts of Eucommia leaves, 6 parts of tangerine peel, 6 parts of Panax notoginseng, 14 parts of knotweed, 5 parts of earthworm, 10 parts of purslane, 4 parts of ginkgo biloba, 2 parts of poria cocos, 6 parts of kudzu root, 5 parts of cassia seed , 12 parts of Hawthorn, 3 parts of Gastrodia elata.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 17 parts of mountain plant leaves, 15 parts of scorpion, 7 parts of angelica, 11 parts of pangolin, 16 parts of Achyranthes bidentata, 8 parts of salvia miltiorrhiza 8 parts of safflower, 16 parts of Atractylodes macrocephala, 14 parts of Tribulus terrestris, 11 parts of capillary, 3 parts of Morus alba, 5 parts of notopterygium, 13 parts of Caulis Spatholobus, 14 parts of Uncaria, 5 parts of Chuanxiong, 12 parts of fragrant chrysanthemum , 3 parts of snow lotus, 1 part of eucommia leaf, 10 parts of tangerine peel, 9 parts of notoginseng, 13 parts of knotweed, 7 parts of earthworm, 11 parts of purslane, 3 parts of ginkgo leaf, 1 part of poria cocos, 10 parts of kudzu root, 4 parts of cassia seed , Hawthorn 11 parts, Gastrodia elata 4 parts.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 15 parts of mountain plant leaves, 12 parts of scorpion, 5 parts of angelica, 9 parts of pangolin, 15 parts of Achyranthes bidentata, 9 parts of salvia miltiorrhiza 7 parts of safflower, 19 parts of Atractylodes macrocephala, 13 parts of Tribulus terrestris, 10 parts of capillary, 4 parts of Morus alba, 4 parts of notopterygium, 11 parts of Caulis Spatholobus, 11 parts of Uncaria, 5 parts of Chuanxiong, and 10 parts of fragrant chrysanthemum , 5 parts of snow lotus, 3 parts of Eucommia leaves, 8 parts of tangerine peel, 8 parts of notoginseng, 14 parts of knotweed, 9 parts of earthworm, 12 parts of purslane, 5 parts of ginkgo leaf, 3 parts of poria cocos, 8 parts of kudzu root, 6 parts of cassia seed , Hawthorn 9 parts, Gastrodia elata 5 parts.

In a preferred embodiment, the composition and parts by weight of raw materials for making the pharmaceutical composition are: 19 parts of mountain plant leaves, 14 parts of scorpion, 6 parts of angelica, 7 parts of pangolin, 14 parts of Achyranthes bidentata, 9 parts of salvia miltiorrhiza 6 parts of safflower, 17 parts of Atractylodes macrocephala, 13 parts of Tribulus terrestris, 10 parts of capillary, 4 parts of Morus alba, 4 parts of notopterygium, 11 parts of Caulis Spatholobus, 11 parts of Uncaria, 5 parts of Chuanxiong, and 10 parts of fragrant chrysanthemum , 5 parts of snow lotus, 3 parts of Eucommia leaves, 8 parts of tangerine peel, 8 parts of Panax notoginseng, 14 parts of knotweed, 4 parts of earthworm, 9 parts of purslane, 5 parts of ginkgo leaf, 3 parts of poria cocos, 8 parts of kudzu root, 3 parts of cassia seed , 8 parts of Hawthorn, 5 parts of Gastrodia elata.

In a preferred embodiment, the traditional Chinese medicine composition is prepared according to the following method:

(1) Get each medical material of the weight component in the arbitrary described pharmaceutical composition of claim 2-8, add 5-10 times the amount of ethanol and soak in 1-2 hour, heat extraction 2 times, each 1-2 hour , remove the supernatant, combine the extracts, filter through 100-120 mesh, and then ultra-filter through an ultra-filtration column with a cut-off molecular weight of 5000-10000. Concentrate to a paste, let it stand for later use;

(2) Put the dregs extracted by ethanol into 10 times the amount of water, then put it into an extraction tank and heat and boil for 1 hour, filter, and the filtrate is standby; add water to the filter residue, heat for the second time, boil for 45 minutes, filter, and the filtrate is standby;

(3) Combine the two filtrates in step (2), filter with gauze, add 50-60% ethanol to the residue, continue leaching for 2 hours at 60°C-70°C, stir once every 10min, filter with gauze, and combine leaching liquid, concentrated into a paste;

(4) The paste obtained by concentrating step (1) and the paste obtained by step (3) are recovered under reduced pressure to ethanol and concentrated to a concentration of 0.6-0.7g crude drug/mL. After suction filtration, the relative The density is about 1.0-1.1 at 20°C; centrifuge at a speed of 3000r/min; spray dry at 60°C-80°C to obtain a dry extract;

(5) Grinding the dry extract prepared in step (4), adding an appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and sizing to obtain granules; or the step (4) ) dried and crushed dry extract to make a powder; or crush the dry extract obtained in step (4), add an appropriate amount of micropowder silica gel and α-galactose to mix, use ethanol as a wetting agent, and granulate, Drying, granulation, packing into capsules to obtain capsules; or crushing the dry extract prepared in step (4), adding appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and granulation, Tablets are prepared; or an appropriate amount of sucrose and essence are added to the centrifuged concentrate obtained in the above step (4), mixed, sterilized, and filled to obtain a liquid medicine.

The present invention also relates to an application of the pharmaceutical composition in medicine for softening blood vessels.

The pharmaceutical composition for softening blood vessels provided by the present invention uses common Chinese herbal medicines as raw materials to fully exert the medicinal properties of each component:

The total flavonoids contained in the leaves of the mountain plants have a wide range of pharmacological effects, especially beneficial to the cardiovascular system. Experimental studies have shown that the total flavonoids of mountain plant leaves have the functions of lowering blood pressure, reducing peripheral vascular resistance, expanding coronary arteries, increasing coronary flow, reducing myocardial oxygen consumption, strengthening the heart, increasing cardiac output, anti-myocardial ischemia, anti-platelet aggregation, Improving blood rheology, eliminating oxygen free radicals, detoxifying and reducing blood pressure, enhancing hypoxia tolerance and diuretic and other pharmacological effects. It is safe and effective to prevent and treat angina pectoris of coronary heart disease, hypertension, arrhythmia, hyperlipidemia, atherosclerosis, etc., and is worthy of popularization and application. Shanzhiye is very rich in resources in various parts of our country, especially in the western region, and has high development value.

Danshen, bitter, slightly cold. GUIXIN, Liver Channel. Dispelling blood stasis and relieving pain, promoting blood circulation to stimulate menstrual flow, clearing away heart-fire and relieving restlessness. For irregular menstruation, amenorrhea dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, heat arthralgia pain, sore swelling and pain, vexation and insomnia. It is used for sternocostal and hypochondriac pain, rheumatic arthralgia, lumps in the abdomen, swelling and pain of sores, pain from falls, irregular menstruation, amenorrhea dysmenorrhea, postpartum stasis and pain, etc. It is effective in treating sternocostal pain, lumps in the abdomen, irregular menstruation and amenorrhea. "Compendium" contains: Danshen, according to "Furen Ming Theory", Siwu Decoction can be used to treat women's diseases, regardless of prenatal and postpartum, and the amount of menstrual fluid, but Danshen powder is the same, and the indications are the same. Salvia miltiorrhiza can break old blood, replenish new blood, give birth to a fetus, stop stillbirth, stop stagnation in metrorrhagia, and regulate meridians. Tanshinone, the main component of Danshen, has the effects of dilating blood vessels, improving circulation, and relieving intravascular coagulation. It has the effect of promoting blood circulation and promoting blood circulation in the liver, which is beneficial to liver cell regeneration.

Scorpion has a long history of edible and medicinal use. The main medicinal ingredient of the scorpion is scorpion toxin. According to "Compendium of Materia Medica" and "Chinese Pharmacopoeia", the scorpion has the functions of "expelling wind and spasm, reducing inflammation and attacking poison, dredging collaterals and relieving pain"; , skin diseases, cardiovascular and cerebrovascular diseases, inflammation, hepatitis B, tumors and other diseases. Scorpion is also a high-end delicacy, rich in nutrition, and has the functions of preventing and curing diseases, enhancing immunity and anti-aging.

Pangolin, the part used as medicine, the scales of pangolin, efficacy and action: promoting blood circulation and dispelling stagnation; promoting menstrual flow and releasing breast milk; eliminating carbuncle and ulcer. Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Milk retention; Carbuncle; Scrofula. For amenorrhea lump in the abdomen, milk barrier, carbuncle sore, joint arthralgia, numbness and spasm.

Radix Achyranthes Radix: bitter in the mouth, sour; Property flat, return liver; Kidney meridian, has liver and kidney invigorating; Strengthening muscles and bones; Promoting blood circulation to stimulate menstrual flow; Causing fire (blood) descending; The effect of inducing diuresis to treat stranguria, mainly cures soreness of the waist and knees; Atrophy of the lower limbs; Amenorrhea due to stagnation of blood; dysmenorrhea; postpartum blood stasis and abdominal pain; lump in the abdomen; retained clothes; hot stranguria; bloody stranguria; bruises;

Notopterygium, pungent in taste; bitter; warm in nature. Expelling exterior cold; expelling rheumatism; sharpening joints; relieving pain. Main exogenous cold; headache without sweat; Feng Shui edema; sore swelling. For impotence and nocturnal emission, enuresis and frequent urination, cold pain in the waist and knees, asthma due to kidney deficiency, diarrhea at dawn; external use for treating vitiligo and alopecia areata. Relieve the exterior and dispel cold, expelling wind and dampness, relieving pain.

Atractylodes macrocephala bitter in the mouth, sweet, warm. Return spleen, stomach warp. Cure mainly invigorating the spleen and replenishing qi, drying dampness and diuresis, antiperspirant, antiabortive. For insufficiency of the spleen, lack of food, abdominal distension and diarrhea, dizziness and palpitation due to phlegm and retention, edema, spontaneous sweating, restless fetal movement. Atractylodes macrocephala has cytotoxic effect on tumor cells, can reduce the proliferation rate of tumor cells, reduce the invasiveness of tumor tissues, and improve the body's anti-tumor response ability. Atractylodes macrocephala volatile oil has inhibitory effect on Ehrlich ascites carcinoma, lymphosarcoma ascites type, esophageal carcinoma (Ecal09), sarcoma 180, etc. in mice. Effect of intraperitoneal injection of atractyloid B on sarcoma in mice. There is also a significant inhibitory effect. "On the Nature of Medicine" contains it: Jun, sweet in the mouth, pungent, nontoxic. Can control strong wind numbness, dysentery due to dysentery for many years, confidant's distending pain, breaks away food, whets the appetite, removes phlegm and salivation, removes cold and heat, and stops diarrhea. The main face is radiant, calms the face, and removes blackness. Control water swelling and fullness, vomiting and nausea, cold pain in the abdomen, vomiting and diarrhea, and cold dysentery due to stomach qi deficiency.

Tribulus terrestris is the ripe fruit of Tribulus terrestris L, an annual or perennial herb of Tribulus terrestris L, which is bitter, pungent, flat, and enters the Liver Channel. Suppressing liver and relieving stagnation, expelling wind and improving eyesight. For liver yang dizziness headache, liver depression hypochondriac pain, wind-heat headache, conjunctival congestion and swelling pain, skin itching embolism.

Radix Notoginseng: Radix Notoginseng is sweet in nature, slightly bitter in taste, warm in nature, and returns to the liver and stomach meridians. Its roots and rhizomes are used as medicine. It is a precious Chinese herbal medicine. It can stop bleeding, remove blood stasis, reduce swelling and relieve pain when used raw. It has good hemostatic effect and significant hematopoietic function; it can strengthen and improve coronary microcirculation. Sanqi has a long history of being used as medicine. Therefore, there is a saying that "gold is not exchanged". Notoginseng "slightly sweet and bitter, similar to the taste of ginseng." "Anyone who is injured by a stick and bruised and dripping with blood should stop immediately after chewing, and the bruise will disappear. If you receive a stick, take a dose first. , two coins, the blood does not rush to the heart, it is especially suitable to be taken after the stick, and it is also good to take after giving birth. Generally speaking, this medicine has a warm temperature, sweet and slightly bitter taste, and it is divided into Yangming and Jueyin blood, so it can cure all blood diseases." . "Materia Medica Seeking Truth" records: "Sanqi, the world only knows its function to stop bleeding and relieve pain. They don't know that pain is caused by blood stasis, and blood stops due to application. The smell of Sanqi is bitter and warm, and it can differentiate blood stasis in the blood." Panax notoginseng can increase coronary blood flow, slow down heart rate, reduce myocardial oxygen consumption, increase myocardial oxygen tolerance, improve microcirculation, and relieve smooth muscle spasm.

Yinchen: bitter, pungent, slightly cold in nature. Return spleen, stomach, liver, gall bladder channel. Functions and indications: clearing damp-heat, reducing jaundice. For jaundice oliguria, eczema itching; infectious jaundice hepatitis. "The Classic": main rheumatism, cold and heat evil, heat knot jaundice. "Bie Lu": control the yellowing of the whole body, difficulty in urination, remove head heat, and remove phlegm. "Supplements to Materia Medica": clear joints, remove stagnant heat, and use it for typhoid fever. "Yi Lin Zhuan Yao": strengthening the kidney, drying the spleen and dampness, removing stagnation, and relieving fever. "Materia Medica Zaixin": Purging fire, calming the liver, resolving phlegm, relieving cough and sweating, promoting dampness, reducing swelling, and treating sores and fires.

Morus alba L. is the root bark of the Moraceae plant Morusalba L. Mainly produced in Anhui, Henan, Zhejiang, Jiangsu, Hunan and other places. Efficacy: Xiefei relieves asthma, promotes water to reduce swelling. For lung-heat cough and asthma, facial edema, dysuria embolism. "On the Properties of Medicine": make, flat. It can cure the fullness of the lungs and asthma, water vapor edema, main injury, diuresis, eliminate water vapor, exhaustion and heat headache, deficiency of internal tonic. "Rihuazi Materia Medica": Warming, regulating the middle, lowering the breath. Eliminates phlegm and quenches thirst, sharpens the large and small intestines, whets the appetite, eats food, kills abdominal insects, stops cholera vomiting and diarrhea.

Spatholobus Spatholobus, bitter in nature, sweet, warm. Return liver, kidney meridian, enrich blood, invigorate blood circulation, dredging collaterals. For irregular menstruation, blood deficiency and chlorosis, numbness and paralysis, rheumatic arthralgia, promoting blood circulation and relaxing tendons; nourishing blood and regulating menstruation, "Compendium of Materia Medica Supplements" contains that it can treat numbness of hands and feet; limb paralysis; rheumatic arthralgia; women have irregular menstruation; dysmenorrhea . External use is a good gynecological medicine for promoting blood circulation and removing stasis.

Uncaria, sweet in taste, cool in nature. Go into liver, heart channel. Can clear away heat and calm the liver, calm wind and calm convulsions. It is mainly used to treat children with convulsions and epilepsy, adults with high blood pressure, dizziness and dizziness, and women with eclampsia. Its pharmacological effects have sedative and antihypertensive effects.

Safflower is warm in nature and pungent in taste. Functions and indications apply to promoting blood circulation, dispelling blood stasis and relieving pain. For amenorrhea, dysmenorrhea, lochia, lumps in the abdomen, bruises. "Materia Medica Huiyan": Safflower, the medicine for breaking blood, promoting blood circulation, harmonizing blood, and regulating blood. The main fetal birth is caused by various diseases and blood, or blood troubles and blood dizziness, dizziness and silence; or lochia grabs the heart, umbilical abdominal colic; card, non-safflower cannot be cured. If postpartum haemorrhage, mouth shut up and finger pricking; or evil enters the blood chamber, delirium and madness; All such as amenorrhea with cold and heat, or expired abdominal pain with purple and black dripping, or injury with qi and blood stasis, or sores with itching and swollen ulcers are all symptoms of disharmony between qi and blood, and non-safflower cannot Tune in, safflower promote blood circulation and stimulate menstruation, reduce swelling and relieve pain, have the effects of inhibiting thrombosis, anti-inflammation, and pain relief, have the effect of constricting blood vessels by eliminating adrenaline and norepinephrine, and have the effect of "tongli meridian".

Fragrant Chrysanthemum: Alpine Fragrant Chrysanthemum, or Kunlun Snow Chrysanthemum, can effectively lower blood fat, soften blood vessels, remove garbage in the body, achieve body fluid balance, increase cardiac output, increase myocardial oxygen supply, and protect normal physiological functions of ischemic myocardium. Heart disease, hyperlipidemia, and diabetes have special curative effects.

Poria cocos is sweet, light, and flat in nature. When used as medicine, it has the functions of diuresis and dampness, spleen and stomach, and calming the mind. Modern medical research: Poria cocos can enhance the immune function of the body, and Poria cocos polysaccharide has obvious anti-tumor and liver-protecting effects. Poria cocos is sweet and flat in nature and flavor, and enters the heart, lung and spleen meridians. It has the effects of eliminating dampness and diuresis, invigorating the spleen and stomach, calming the mind and calming the nerves. It can cure dysuria, edema and fullness, phlegm retention and cough, vomiting, nausea, diarrhea, spermatorrhea, stranguria, palpitations, and amnesia. The diuresis of Poria cocos is achieved by invigorating the functions of the spleen and lungs, which is different from other traditional Chinese medicines that directly diuresis. For spleen deficiency diarrhea, taking Poria cocos can not only strengthen the spleen, but also ooze dampness. For diarrhea and leukorrhea caused by spleen deficiency, Poria cocos has the effect of taking care of both specimens and is often compatible with Codonopsis pilosula, Atractylodes macrocephala, and Chinese yam. It can be used as an adjuvant medicine for invigorating the lung and spleen and treating qi deficiency.

Saussurea: Saussurea has physiologically active active ingredients. Among them, umbelliferone has obvious antibacterial, antihypertensive, sedative, and antispasmodic effects; it has wind-dispelling, anti-inflammatory, pain-relieving, expectorant, and anti-tumor effects, and can inhibit the growth of cancer cells. It is clinically used to treat cancer, especially with Breast cancer has a certain effect, and it also has a certain effect on skin cancer, leukemia and He Jin's disease. Specific effect on acute attack of gout.

Eucommia ulmoides leaves are the dried leaves of Eucommia ulmoides Oliv. Harvest in summer and autumn when the branches and leaves are lush, and dry in the sun or at low temperature. Slightly pungent, warm. Return liver, kidney channel. Functions and indications: nourish liver and kidney, strengthen muscles and bones. For insufficiency of liver and kidney, dizziness, soreness of waist and knees, flaccidity of muscles and bones. The effects on the cardiovascular system and the heart: Eucommia leaf decoction and alcohol precipitation solution 0.2g can significantly increase the coronary blood flow in isolated guinea pig hearts. Intravenous injection of 20g/kg in rabbits has no antagonistic effect on ST-segment elevation and T wave changes caused by intravenous isoproterenol. Antihypertensive effect After intravenous injection of Eucommia leaf water decoction 0.4g/kg in anesthetized dogs and cats, blood pressure drops rapidly and gradually rises after maintaining for 5 minutes; when intravenous injection of doses above 1g/kg, blood pressure drops significantly and can be maintained for a long time. Alcohol extract also has antihypertensive effect, but the antihypertensive range and maintenance time are worse than water decoction. The antihypertensive tests of anesthetized dogs and cats have all proved that repeated intravenous administration of Eucommia leaf water decoction and alcohol extract in a short period of time can produce tachyphylaxis, and the antihypertensive effect cannot even appear after continuous administration of 3-4 times. The water decoction of Eucommia leaves and the 6g/kg intravenous injection of 65% ethanol extract can both cause a significant drop in blood pressure in rabbits. The aqueous solution, alcohol solution, ether solution and purified components of Eucommia leaves, such as sugars, alkaloids, aucubin, and chlorogenic acid, are administered intravenously to rabbits, all of which have different degrees of antihypertensive effects.

Angelica is sweet and heavy in taste, so it can nourish blood, and its qi is light and pungent, so it can also promote blood, tonic has movement, and tonic has tonic. It is the qi medicine in the blood and the holy medicine in the blood. If it is supplemented with supplements, it will be supplemented, so it can nourish and nourish blood, nourish qi and generate essence, calm the five internal organs, strengthen the body, and benefit the mind. It is suitable for all diseases of physical deficiency. It can relieve pain and relieve constipation, benefit muscles and bones, and treat spasms, paralysis, dryness, astringency and other syndromes. For those who are deficient and unable to understand the exterior, add Chai, Ge, Ma, Gui and other agents, which can greatly dissipate the exterior and defend heat, but for those who do not restrain the exterior, add rhubarb and the like, which can also strengthen the exterior. However, its qi is pungent and moves, so those who want it to be quiet should avoid it, those with slippery nature and good behavior, and those who have loose stools should avoid it. For those with excessive fire in yin, angelica can move blood, which is not suitable. For those with deficiency of yang in yin, angelica can nourish blood, which is indispensable.

Rhizoma Chuanxiong, pungent, warm. Go into liver, gallbladder meridian. Promoting qi to relieve depression, eliminating wind and dampness, promoting blood circulation and relieving pain. Control wind-cold headache, dizziness, hypochondriac pain, abdominal pain, arthralgia due to cold, cramps, amenorrhea, dystocia, postpartum stasis block pain, carbuncle sore. For irregular menstruation, amenorrhea dysmenorrhea, abdominal pain in the abdomen, tingling pain in the chest and hypochondrium, tumbling and swelling pain, headache, rheumatic arthralgia. "The Classic" contains it: the main apoplexy into the brain headache, cold arthralgia, spasm emergency, metal wounds, women with blood closed and childless. "Bie Lu" contains it: "In addition to the cold movement in the brain, the wind coming and going upstream on the face, tears coming out of the eyes, excessive tears and saliva, sudden drunkenness, all kinds of cold air, hard pain in the heart and abdomen, evil in the heart, sudden swelling and pain, threat of wind Pain, warming the middle and internal cold." It is a good medicine for promoting qi and removing blood stasis.

Tangerine peel is warm in nature, pungent in taste and bitter in taste. Go into spleen channel, stomach channel, lung channel. Regulates qi and invigorates the spleen, regulates the middle, dries dampness, and resolves phlegm. Indications for abdominal fullness or pain due to stagnation of spleen and stomach Qi, and indigestion. Chest tightness, abdominal distension, loss of appetite and loose stool in damp turbidity resistance. Cough and asthma caused by phlegm damp blocking the lung. It is used for fullness in the chest cavity, vomiting and diarrhea due to lack of food, and cough with excessive phlegm. "Compendium of Materia Medica": It's the best and always take the power of chess to regulate qi and dry dampness. If it is used with tonic, it will be tonic, if it is used with laxative, it will relieve, if it is used with ascending medicine, it will be raised, and if it is used with descending medicine, it will be lowered. The spleen is the mother of vital qi, and the lungs are the key to absorbing qi. Therefore, orange peel is the key to the division of qi in the two meridians, but it can be used to nourish, reduce, and ascend. "Daily Materia Medica": It can disperse and relieve diarrhea, warm and nourish, eliminate diaphragmatic qi, reduce phlegm and salivation, harmonize spleen and relieve cough, and relieve five stranguria.

Polygonum cuspidatum slightly bitter, slightly cold. Return liver, gallbladder, lung meridian. It has the functions of clearing heat and detoxifying, promoting gallbladder and reducing jaundice, dispelling wind and dampness, dissipating blood stasis and relieving pain, relieving cough and reducing phlegm. Cure mainly joint arthralgia, damp-heat jaundice, amenorrhea, lump in the abdomen, cough with profuse phlegm, water and fire burns, injury from falls, carbuncle and sore. Pregnant women use with caution.

Earthworm: salty in taste and cold in nature, returns to the Liver, Spleen, and Bladder Meridians, clears away heat and relieves wind, dredges collaterals, relieves asthma and promotes diuresis. Modern pharmacological research shows that earthworm has analgesic, anticonvulsant, antipyretic, antihypertensive, antithrombotic, and antitumor effects.

Purslane diuresis reduces swelling and lowers blood pressure. Purslane contains a large amount of potassium salt, which has a good diuresis and swelling effect; potassium ions can also directly act on the blood vessel wall to expand the blood vessel wall and prevent the arterial wall from thickening, thereby lowering blood pressure. The medicinal function is to clear away heat and detoxify, cool blood and stop bleeding. Because it is rich in norepinephrine, it can promote the secretion of insulin by the pancreas, regulate the process of glucose metabolism in the human body, reduce blood sugar concentration, and keep blood sugar constant, so it has a certain therapeutic effect on diabetes. In addition, it also contains a kind of unsaturated fatty acid called 3-W, which can inhibit the production of cholesterol and triglyceride, and has a protective effect on cardiovascular. "Compendium of Materia Medica": "Scatter blood and reduce swelling, sharpen intestines and smooth tires, detoxify and relieve stranguria, and treat postpartum sweating."

Ginkgo biloba: functions and indications: relieving asthma, promoting blood circulation and removing blood stasis, relieving pain, used for cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipidemia.

Radix Puerariae, sweet in taste, pungent, cool in nature. Go into spleen, stomach warp. It has the effects of promoting yang and relieving muscles, penetrating rash and stopping diarrhea, eliminating restlessness and stopping temperature. It is used for typhoid fever, warm-heat headache and strong neck, dysphoria and thirst, diarrhea, dysentery, impervious rash, high blood pressure, angina pectoris, and deafness. It is clinically used to treat stiff neck pain in hypertension, angina pectoris in coronary heart disease, and also has hypoglycemic effect.

Cassia is the mature seed of the leguminous plant Cassia, also known as Cassia. "Shen Nong's Materia Medica" records that cassia seed is sweet, bitter and slightly cold, and belongs to the three meridians of liver, gallbladder and kidney. etc. In recent years, it has been used clinically for the treatment of hypertension. Semen Cassiae contains anthracene glycosides, which can be decomposed to produce emodin, emodin methyl ether, rhein, chrysophanol and glucose. Experiments have proved that Semen Cassiae has the functions of lowering blood pressure, lowering blood fat, and antibacterial effects, and has certain curative effect in treating hyperlipidemia. In addition to medicinal ingredients, cassia seeds also contain a variety of vitamins and rich amino acids, carbohydrates and so on.

Hawthorn: sex, slightly warm. Taste, sweet, sour. Go into spleen, stomach, liver channel. This product is good at dispelling stagnation of qi, eliminating indigestion and accumulation; it circulates qi and blood, promotes blood circulation and removes blood stasis, and has good curative effect on treating hyperlipidemia and hypertension; it can lower blood fat, resist atherosclerosis, and lower serum cholesterol and triglycerides; it can also expand coronary arteries, increase coronary flow, protect myocardial ischemia and hypoxia, strengthen the heart, lower blood pressure and resist arrhythmia; remove blood stasis without hurting new blood, open up depression without hurting righteousness, Its nature is especially peaceful.

Gastrodia elata: sex, flat. taste, sweet. Mainly enters the Liver Channel. This product relieves wind and spasm, calms liver-yang, dispels wind and dredges collaterals. It is an important medicine for treating dizziness and headache; it is also a good product for numbness of limbs, paralysis of hands and feet, rheumatic arthralgia, and spasm of muscles and bones.

The theory of traditional Chinese medicine believes that the "three highs" are mainly caused by the imbalance of yin and yang in the functions of the heart, liver, and kidneys, plus the invasion of external evils such as wind, heat, and poison, and the interaction of phlegm and blood stasis in the human body, as well as various factors. caused by mutual influence. Therefore, it is an effective way to treat the "three highs" by calming the liver and suppressing yang, regulating qi and promoting blood circulation, nourishing yin and nourishing kidney, clearing heat and removing blood stasis. An ideal drug should be able to reverse its pathological process while softening blood vessels, prevent and prevent complications, and should have no obvious toxic and side effects. The present invention is based on the above-mentioned theory and is developed by integrating various Chinese herbal medicines. The present invention can quickly promote blood circulation and remove blood stasis, dredge meridians and activate collaterals, be used for hyperlipidemia, reduce blood viscosity, soften blood vessels, and regulate blood lipids, and has unique curative effects for treating and preventing "three highs".

The compatibility of the pharmaceutical composition for softening blood vessels of the present invention conforms to the principle of "junchenzuoshi" of traditional Chinese medicine, with prominent focus and comprehensive rationality. Oral medicine can regulate visceral functions, reduce blood lipids, soften blood vessels, make blood thinner, increase blood flow vitality, and soften blood vessels The invention has obvious effects, abundant raw materials, simple preparation process, no toxic and side effects, and low price, and has good application prospects in softening blood vessels, treating and preventing "three highs", especially hyperlipidemia.

detailed description

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments. Apparently, the described embodiments are part, but not all, of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention. Unless otherwise specified, the percentage of ethanol in the present invention is volume percentage, and v/v represents the volume ratio of the solution.

Example 1:

A pharmaceutical composition for softening blood vessels of the present invention, the following Chinese medicine raw materials are taken: 12 grams of mountain plant leaves, 16 grams of scorpion, 3 grams of angelica, 12 grams of pangolin, 12 grams of Achyranthes bidentata, 10 grams of salvia miltiorrhiza, 9 grams of safflower , 15 grams of Atractylodes macrocephala, 15 grams of Tribulus terrestris, 8 grams of capillary, 5 grams of Morus alba, 3 grams of Qianghuo, 14 grams of Caulis Spatholobus, 9 grams of Uncaria, 6 grams of Chuanxiong, 8 grams of fragrant chrysanthemum, 5 grams of Saussurea ulmoides, Eucommia 1 gram of leaves, 10 grams of tangerine peel, 5 grams of Panax notoginseng, 16 grams of Polygonum cuspidatum, 10 grams of earthworm, 8 grams of purslane, 5 grams of ginkgo leaf, 1 gram of poria cocos, 10 grams of kudzu root, 6 grams of cassia seed, 8 grams of hawthorn, Gastrodia elata 3 grams.

Example 2:

A pharmaceutical composition for softening blood vessels of the present invention, the following traditional Chinese medicine raw materials are taken: 20 grams of mountain plant leaves, 10 grams of scorpion, 8 grams of angelica, 5 grams of pangolin, 17 grams of Achyranthes bidentata, 12 grams of salvia miltiorrhiza, 4 grams of safflower , 20 grams of Atractylodes macrocephala, 10 grams of Tribulus terrestris, 12 grams of capillary, 2 grams of Morus alba, 7 grams of Qianghuo, 11 grams of Caulis Spatholobus, 15 grams of Uncaria, 3 grams of Chuanxiong, 13 grams of fragrant chrysanthemum, 3 grams of Saussurea ulmoides, Eucommia 3 grams of leaves, 5 grams of tangerine peel, 10 grams of Panax notoginseng, 13 grams of Polygonum cuspidatum, 3 grams of earthworm, 13 grams of purslane, 3 grams of ginkgo biloba, 3 grams of Poria cocos, 5 grams of kudzu root, 4 grams of cassia seed, 10 grams of hawthorn, Gastrodia elata 4 grams.

Example 3:

A pharmaceutical composition for softening blood vessels of the present invention, the following Chinese medicine raw materials are taken: 13 grams of mountain plant leaves, 11 grams of scorpion, 4 grams of angelica, 6 grams of pangolin, 13 grams of Achyranthes bidentata, 7 grams of salvia miltiorrhiza, 5 grams of safflower , 18 grams of Atractylodes macrocephala, 11 grams of Tribulus terrestris, 9 grams of capillary, 4 grams of Morus alba, 6 grams of notopterygium, 12 grams of Caulis Spatholobus, 13 grams of Uncaria, 4 grams of Chuanxiong, 9 grams of fragrant chrysanthemum, 4 grams of snow lotus, Eucommia 2 grams of leaves, 6 grams of tangerine peel, 6 grams of Panax notoginseng, 14 grams of Polygonum cuspidatum, 5 grams of earthworm, 10 grams of purslane, 4 grams of ginkgo biloba leaves, 2 grams of Poria cocos, 6 grams of kudzu root, 5 grams of cassia seed, 12 grams of hawthorn, Gastrodia elata 3 grams.

Example 4:

A pharmaceutical composition for softening blood vessels of the present invention, the following traditional Chinese medicine raw materials are taken: 17 grams of mountain plant leaves, 15 grams of scorpion, 7 grams of angelica, 11 grams of pangolin, 16 grams of Achyranthes bidentata, 8 grams of salvia miltiorrhiza, and 8 grams of safflower , 16 grams of Atractylodes macrocephala, 14 grams of Tribulus terrestris, 11 grams of capillary, 3 grams of Morus alba, 5 grams of notopterygium, 13 grams of Caulis Spatholobus, 14 grams of Uncaria, 5 grams of Chuanxiong, 12 grams of fragrant chrysanthemum, 3 grams of snow lotus, Eucommia 1 gram of leaves, 10 grams of tangerine peel, 9 grams of Panax notoginseng, 13 grams of Polygonum cuspidatum, 7 grams of earthworm, 11 grams of purslane, 3 grams of ginkgo leaf, 1 gram of poria cocos, 10 grams of kudzu root, 4 grams of cassia seed, 11 grams of hawthorn, Gastrodia elata 4 grams.

Example 5:

A pharmaceutical composition for softening blood vessels of the present invention, the following Chinese medicine raw materials are taken: 15 grams of mountain plant leaves, 12 grams of scorpion, 5 grams of angelica, 9 grams of pangolin, 15 grams of Achyranthes bidentata, 9 grams of salvia miltiorrhiza, 7 grams of safflower , 19 grams of Atractylodes macrocephala, 13 grams of Tribulus terrestris, 10 grams of capillary, 4 grams of Morus alba, 4 grams of Qianghuo, 11 grams of Caulis Spatholobus, 11 grams of Uncaria, 5 grams of Chuanxiong, 10 grams of fragrant chrysanthemum, 5 grams of Saussurea ulmoides, Eucommia 3 grams of leaves, 8 grams of tangerine peel, 8 grams of Panax notoginseng, 14 grams of Polygonum cuspidatum, 9 grams of earthworm, 12 grams of purslane, 5 grams of ginkgo leaf, 3 grams of poria cocos, 8 grams of kudzu root, 6 grams of cassia seed, 9 grams of hawthorn, Gastrodia elata 5 grams.

Embodiment 6:

A pharmaceutical composition for softening blood vessels of the present invention, the following traditional Chinese medicine raw materials are taken: 19 grams of mountain plant leaves, 14 grams of scorpion, 6 grams of angelica, 7 grams of pangolin, 14 grams of Achyranthes bidentata, 9 grams of salvia miltiorrhiza, 6 grams of safflower , 17 grams of Atractylodes macrocephala, 13 grams of Tribulus terrestris, 10 grams of capillary, 4 grams of Morus alba, 4 grams of Qianghuo, 11 grams of Caulis Spatholobus, 11 grams of Uncaria, 5 grams of Chuanxiong, 10 grams of fragrant chrysanthemum, 5 grams of Saussurea ulmoides, Eucommia 3 grams of leaves, 8 grams of tangerine peel, 8 grams of Panax notoginseng, 14 grams of knotweed, 4 grams of earthworm, 9 grams of purslane, 5 grams of ginkgo leaves, 3 grams of poria cocos, 8 grams of kudzu root, 3 grams of cassia seed, 8 grams of hawthorn, Gastrodia elata 5 grams.

Wherein, the preparation method of the described Chinese medicine composition of embodiment 1-6 is:

(1) Get each medicinal material of the weight component in the Chinese medicine composition described in any one of embodiments 1-6, add 5-10 times the amount of ethanol and soak for 1-2 hours, heat and extract 2 times, each 1-2 hours , remove the supernatant, combine the extracts, filter through 100-120 mesh, and then ultra-filter through an ultra-filtration column with a cut-off molecular weight of 5000-10000. Concentrate to a paste, let it stand for later use;

(2) Put the dregs extracted by ethanol into 10 times the amount of water, then put it into an extraction tank and heat and boil for 1 hour, filter, and the filtrate is standby; add water to the filter residue, heat for the second time, boil for 45 minutes, filter, and the filtrate is standby;

(3) Combine the two filtrates in step (2), filter with gauze, add 50-60% ethanol to the residue, continue leaching for 2 hours at 60°C-70°C, stir once every 10min, filter with gauze, and combine leaching liquid, concentrated into a paste;

(4) The paste obtained by concentrating step (1) and the paste obtained by step (3) are recovered under reduced pressure to ethanol and concentrated to a concentration of 0.6-0.7g crude drug/mL. After suction filtration, the relative The density is about 1.0-1.1 at 20°C; centrifuge at a speed of 3000r/min; spray dry at 60°C-80°C to obtain a dry extract;

(5) Grinding the dry extract prepared in step (4), adding an appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and sizing to obtain granules; or the step (4) ) dried and crushed dry extract to make a powder; or crush the dry extract obtained in step (4), add an appropriate amount of micropowder silica gel and α-galactose to mix, use ethanol as a wetting agent, and granulate, Drying, granulation, packing into capsules to obtain capsules; or crushing the dry extract prepared in step (4), adding appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and granulation, Tablets are prepared; or an appropriate amount of sucrose and essence are added to the centrifuged concentrate obtained in the above step (4), mixed, sterilized, and filled to obtain a liquid medicine.

Acute Toxicity Test

method one:

Test materials: 40 Kunming mice, weighing 22-25g. Medicine: the medicinal liquid prepared in Example 3 of the present invention, containing 0.0365mg/ml.

method:

Calculation of LD50: Using the modified Cole's method, the mice were randomly divided into 4 groups, 10 in each group, and the medicinal solution prepared in Example 3 of the present invention was dissolved in distilled water to make the maximum concentration, and given according to the maximum allowable capacity of the mice. The given dosage is 18, 14.4, 11.5, 9.2, 7.4 (g.kg-1) in sequence according to the crude drug amount, and after the animal is fasted (without water) for 18 hours, it is divided into two doses in one day (half an hour apart). ), 0.5ml each time, and observe the death of the animals.

Test results: in the LD50 calculation, when the mice were administered with the maximum allowable concentration and the maximum allowable capacity (18g/Kg.d), no death of the mice was seen, that is, the LD50 was not measured, and only the maximum tolerated dose could be obtained. After 14 days of observation, none of the mice died, no abnormalities were found in the main organs, and no other obvious abnormalities were found. On the 14th day, some mice were sacrificed and autopsied, and no abnormalities were found in the main organs. That is, the dosage equivalent to 300 times of the clinical dose was selected, and no adverse reaction occurred, indicating that the acute toxicity was extremely small, and the MTD was greater than 18g/Kg.d.

Six-month long-term toxicity test: During the administration period, the body weight was weighed once a week, and the food intake was weighed every day. No dead or dying animals were found. The results showed that the mice had smooth coats, and their behaviors, gland secretions, breathing, and feces were normal. Pathological examination indicated that there were no obvious drug-induced pathological changes in various organs.

Clinical justification:

In order to verify the effect of the pharmaceutical composition of the present invention, from October 2012 to May 2014, 180 patients with hyperlipidemia were randomly selected in the outpatient department, aged 45 to 68 (55±10.41) years old, 88 male patients and 92 female patients . The history of hyperlipidemia ranged from 3 to 16 (8.92±3.21) years, and there was no significant difference in weight, height, exercise, diet, etc., P>0.05, including 90 patients with stage 1 hypertension, 65 patients with stage 2 hypertension, and 65 patients with stage 3 hypertension. 25 patients with blood pressure. They were randomly divided into treatment group and control group, 90 cases each.

ECG and laboratory tests:

After admission, blood pressure (BP), electrocardiogram (ECG), glycosylated hemoglobin (Hbaic%), triglyceride (TG), low-density lipoprotein (LDLC), high-density lipoprotein (fHDL), etc. were routinely checked.

treat

The control group received routine treatment, such as Xinkeshu Tablets, Jiangzhiling Tablets and other conventional drugs, and active exercise.

The treatment group used the tablet of Example 3 for treatment, two tablets each time, 2-3 times a day, 10 days as a course of treatment, 2-4 courses of continuous treatment, without adding other treatment methods of traditional Chinese medicine or western medicine.

Efficacy criteria

Cure: all the symptoms disappeared; the main physical and chemical indicators were normal.

Significantly effective: all symptoms or main symptoms are eliminated; physical and chemical detection indicators are basically normal.

Effective: the main symptoms basically disappeared; the main physical and chemical detection indicators improved.

Invalid: The main physical and chemical detection indicators have no change from before treatment.

result:

The curative effect comparison results of the two groups of cases after treatment are as follows:

Comparison of clinical curative effect between two groups of patients (case %)

group Number of cases cure markedly effective efficient invalid always valid therapy group 90 27 (30%) 54 (60%) 6 (6.7%) 3 (3.3%) 87 (96.7%) control group 90 4 (4.4%) 27 (30%) 11 (12.2%) 48 (53.3%) 42 (46.7%)

Comparison of clinical efficacy between the two groups: the total effective rate was 96.7% in the treatment group and 46.7% in the control group, and the difference between the two groups was statistically significant (P<0.05). The treatment group was better than the control group. It can be seen that the medicine prepared in the preferred embodiment of the present invention can safely and effectively soften blood vessels, and the effective rate is significantly higher than that of the control group.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be Modifications are made to the technical solutions described in the foregoing embodiments, or equivalent replacements are made to some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. the pharmaceutical composition of a vessel softening, it is characterised in that: the crude drug of described pharmaceutical composition is made up of crataegus pin natifida var. Major leaf, Radix Salviae Miltiorrhizae, Scorpio, Squama Manis, Radix Achyranthis Bidentatae, Rhizoma Et Radix Notopterygii, the Rhizoma Atractylodis Macrocephalae, Fructus Atriplicis Sibiricae, Radix Notoginseng, Herba Artemisiae Scopariae, Cortex Mori, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, Folium Crossostephii Chinensis, Poria, Herba Saussureae Involueratae, Folium Eucommiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Rhizoma Polygoni Cuspidati, Pheretima, Herba Portulacae, Folium Ginkgo, Radix Puerariae, Semen Cassiae, Fructus Crataegi, Rhizoma Gastrodiae。

2. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: crataegus pin natifida var. Major leaf 12-20 part, Scorpio 10-16 part, Radix Angelicae Sinensis 3-8 part, Squama Manis 5-12 part, Radix Achyranthis Bidentatae 12-17 part, Radix Salviae Miltiorrhizae 7-12 part, Flos Carthami 4-9 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Fructus Atriplicis Sibiricae 10-15 part, Herba Artemisiae Scopariae 8-12 part, Cortex Mori 2-5 part, Rhizoma Et Radix Notopterygii 3-7 part, Caulis Spatholobi 11-14 part, Ramulus Uncariae Cum Uncis 9-15 part, Rhizoma Chuanxiong 3-6 part, Folium Crossostephii Chinensis 8-13 part, Herba Saussureae Involueratae 3-5 part, Folium Eucommiae 1-3 part, Pericarpium Citri Reticulatae 5-10 part, Radix Notoginseng 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Pheretima 3-10 part, Herba Portulacae 8-13 part, Folium Ginkgo 3-5 part, Poria 1-3 part, Radix Puerariae 5-10 part, Semen Cassiae 3-6 part, Fructus Crataegi 8-13 part, Rhizoma Gastrodiae 3-5 part。

3. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 12 parts of crataegus pin natifida var. Major leaf, Scorpio 16 parts, Radix Angelicae Sinensis 3 parts, Squama Manis 12 parts, Radix Achyranthis Bidentatae 12 parts, Radix Salviae Miltiorrhizae 10 parts, 9 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Atriplicis Sibiricae 15 parts, Herba Artemisiae Scopariae 8 parts, Cortex Mori 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Caulis Spatholobi 14 parts, Ramulus Uncariae Cum Uncis 9 parts, Rhizoma Chuanxiong 6 parts, Folium Crossostephii Chinensis 8 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 1 part, Pericarpium Citri Reticulatae 10 parts, Radix Notoginseng 5 parts, Rhizoma Polygoni Cuspidati 16 parts, Pheretima 10 parts, Herba Portulacae 8 parts, Folium Ginkgo 5 parts, 1 part of Poria, Radix Puerariae 10 parts, Semen Cassiae 6 parts, Fructus Crataegi 8 parts, 3 parts of Rhizoma Gastrodiae。

4. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 20 parts of crataegus pin natifida var. Major leaf, Scorpio 10 parts, Radix Angelicae Sinensis 8 parts, Squama Manis 5 parts, Radix Achyranthis Bidentatae 17 parts, Radix Salviae Miltiorrhizae 12 parts, 4 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Atriplicis Sibiricae 10 parts, Herba Artemisiae Scopariae 12 parts, Cortex Mori 2 parts, Rhizoma Et Radix Notopterygii 7 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 15 parts, Rhizoma Chuanxiong 3 parts, Folium Crossostephii Chinensis 13 parts, Herba Saussureae Involueratae 3 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 5 parts, Radix Notoginseng 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Pheretima 3 parts, Herba Portulacae 13 parts, Folium Ginkgo 3 parts, 3 parts of Poria, Radix Puerariae 5 parts, Semen Cassiae 4 parts, Fructus Crataegi 10 parts, 4 parts of Rhizoma Gastrodiae。

5. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 13 parts of crataegus pin natifida var. Major leaf, Scorpio 11 parts, Radix Angelicae Sinensis 4 parts, Squama Manis 6 parts, Radix Achyranthis Bidentatae 13 parts, Radix Salviae Miltiorrhizae 7 parts, 5 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 18 parts, Fructus Atriplicis Sibiricae 11 parts, Herba Artemisiae Scopariae 9 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 6 parts, Caulis Spatholobi 12 parts, Ramulus Uncariae Cum Uncis 13 parts, Rhizoma Chuanxiong 4 parts, Folium Crossostephii Chinensis 9 parts, Herba Saussureae Involueratae 4 parts, Folium Eucommiae 2 parts, Pericarpium Citri Reticulatae 6 parts, Radix Notoginseng 6 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 5 parts, Herba Portulacae 10 parts, Folium Ginkgo 4 parts, 2 parts of Poria, Radix Puerariae 6 parts, Semen Cassiae 5 parts, Fructus Crataegi 12 parts, 3 parts of Rhizoma Gastrodiae。

6. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 17 parts of crataegus pin natifida var. Major leaf, Scorpio 15 parts, Radix Angelicae Sinensis 7 parts, Squama Manis 11 parts, Radix Achyranthis Bidentatae 16 parts, Radix Salviae Miltiorrhizae 8 parts, 8 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 16 parts, Fructus Atriplicis Sibiricae 14 parts, Herba Artemisiae Scopariae 11 parts, Cortex Mori 3 parts, Rhizoma Et Radix Notopterygii 5 parts, Caulis Spatholobi 13 parts, Ramulus Uncariae Cum Uncis 14 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 12 parts, Herba Saussureae Involueratae 3 parts, Folium Eucommiae 1 part, Pericarpium Citri Reticulatae 10 parts, Radix Notoginseng 9 parts, Rhizoma Polygoni Cuspidati 13 parts, Pheretima 7 parts, Herba Portulacae 11 parts, Folium Ginkgo 3 parts, 1 part of Poria, Radix Puerariae 10 parts, Semen Cassiae 4 parts, Fructus Crataegi 11 parts, 4 parts of Rhizoma Gastrodiae。

7. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 15 parts of crataegus pin natifida var. Major leaf, Scorpio 12 parts, Radix Angelicae Sinensis 5 parts, Squama Manis 9 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 9 parts, 7 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 19 parts, Fructus Atriplicis Sibiricae 13 parts, Herba Artemisiae Scopariae 10 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 11 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 10 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 9 parts, Herba Portulacae 12 parts, Folium Ginkgo 5 parts, 3 parts of Poria, Radix Puerariae 8 parts, Semen Cassiae 6 parts, Fructus Crataegi 9 parts, 5 parts of Rhizoma Gastrodiae。

8. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 19 parts of crataegus pin natifida var. Major leaf, Scorpio 14 parts, Radix Angelicae Sinensis 6 parts, Squama Manis 7 parts, Radix Achyranthis Bidentatae 14 parts, Radix Salviae Miltiorrhizae 9 parts, 6 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 17 parts, Fructus Atriplicis Sibiricae 13 parts, Herba Artemisiae Scopariae 10 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 11 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 10 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 4 parts, Herba Portulacae 9 parts, Folium Ginkgo 5 parts, 3 parts of Poria, Radix Puerariae 8 parts, Semen Cassiae 3 parts, Fructus Crataegi 8 parts, 5 parts of Rhizoma Gastrodiae。

9. the pharmaceutical composition according to the arbitrary described vessel softening of claim 3-8, it is characterised in that: described Chinese medicine composition is prepared in following manner:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is taken, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, united extraction liquid, 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use；

(2) being put in 10 times amount water by the medicinal residues that ethanol extraction is crossed, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby；

(3) 2 filtrates in step (2) being combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, is condensed into pasty state；

(4) the pastel decompression recycling ethanol that step (1) paste that obtains of concentration and step (3) obtained to be concentrated into liquor strength be 0.6-0.7g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.0-1.1 when 20 DEG C；It is centrifuged under the rotating speed of 3000r/min；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(5) dry extract that step (4) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, granule can be prepared；Or the dry extract that step (4) prepares be dry, pulverize, make powder；Or dry extract step (4) prepared is pulverized, add appropriate micropowder silica gel, α-galactose mixing, with ethanol for wetting agent, granulate, dry, granulate, encapsulated, prepare capsule；Or dry extract step (4) prepared is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, tabletting, prepare tablet；Or to above-mentioned steps (4) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, prepare medicinal liquid agent。

10. the application in vessel softening medicine of the pharmaceutical composition of the vessel softening as described in as arbitrary in claim 1-9。