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CN105687446A - 一种智能中药退热贴的制备方法 - Google Patents

一种智能中药退热贴的制备方法 Download PDF

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CN105687446A
CN105687446A CN201610250052.3A CN201610250052A CN105687446A CN 105687446 A CN105687446 A CN 105687446A CN 201610250052 A CN201610250052 A CN 201610250052A CN 105687446 A CN105687446 A CN 105687446A
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刘彬
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Abstract

本发明涉及一种智能中药退热贴的制备方法，热敷贴由背衬层、凝胶层和网隔膜组成，网隔膜和背衬层分别位于凝胶层的上层和下层，背衬层是无纺布，网隔膜是PET膜、PC胶片或PC膜，凝胶层由蒸馏水、高分子物质、保湿剂、中药提取液、天然清凉剂和吸热剂按照一定比例混合而成。本发明将保湿剂、中药提取液、天然清凉剂、吸热剂负载于高分子凝胶中，从而达到降温退热，补脑安神的效果，本发明无毒、无副作用，物理加药物降温，补脑安神退热效果明显。

Description

一种智能中药退热贴的制备方法
技术领域
本发明涉及一种智能中药退热贴的制备方法。
背景技术
目前市场上的退热产品主要为退烧药和退热贴，退烧药分内服和外用两种，对于婴幼儿应尽量避免药物的服用，而外用退烧药效果又不是很明显，目前退热贴市场主流为水凝胶退热贴，水凝胶退热贴主要以水凝胶为主，有的采用水凝胶加辅助材料，辅助材料为清凉剂、中药和保湿剂，通过水凝胶中所含大量的水分蒸发带走热量，辅助材料延缓水分的蒸发，增加时效性，中药辅助治疗，达到持续退热的目的。
缺陷在于不能根据人体发烧时温度的变化随时进行温度的调节，时效性相对也短，未能达到令人满意效果。
发明内容
本发明所要解决的技术问题是，提供一种智能中药退热贴的制备方法。所制备的退热贴能够根据人体发烧的程度自动调节温度，并辅以中药治疗，疗效好。
为了解决上述技术问题，本发明采用以下技术方案：
一种智能中药退热贴的制备方法，其特征在于按照以下步骤进行：
1）、将高分子物质和蒸馏水按照质量比3～15:85～97分别加入到搅拌釜中，加热至60～98℃，搅拌至完全溶解，产物称为产品A；
2）、将产品A降温至35～50℃，加入一定质量比的保湿剂、中药提取液、天然清凉剂和吸热剂，搅拌均匀；产品A、保湿剂、中药提取液、天然清凉剂和吸热剂的质量比为40～80:0.5～5:1～10:0.5～5:30～90；
3）、冷却至室温，得水凝胶；
4）、用水凝胶在背衬层上涂布，涂层厚度为0.25mm～1mm，剪切得药敷贴半成品；
5）、在药敷贴上压上网隔膜，得到智能中药退热贴；
所述高分子物质是聚丙烯酰胺、聚丙烯酸钠、海藻酸钠和明胶中的一种或任意比例的两种以上；
所述保湿剂是丙三醇、丙二醇和山梨醇中的一种或任意比例的两种以上；
所述中药提取液是五味子提取液、龙眼肉提取液、大枣提取液、柏子仁提取液、莲子提取液、茯苓提取液、防风提取液、大青叶提取液、四季青提取液、板蓝根提取液和连翘提取液提取液按照质量比5:5:3:6:7:10:2:3:6:9:1的组合物；
所述天然清凉剂是薄荷油和薄荷醇中的一种或任意比例的两种；
所述吸热剂是硝酸铵、氯化铵、硝酸钾和尿素中的一种或任意比例的两种以上。
所述背衬层是无纺布。
所述网隔膜是PET膜、PC胶片或PC膜。
步骤1）中，高分子物质和蒸馏水按照质量比9:91，高分子物质是聚丙烯酰胺和明胶按照质量比3:6复配，加热至85℃；
步骤2）中，降温至35℃，产品A、保湿剂、中药提取液、天然清凉剂和吸热剂的质量比为42:3:9:2:44，其中保湿剂是丙三醇和丙二醇按照质量比1:2复配，天然清凉剂是薄荷油和薄荷醇按照质量比1:1复配，吸热剂是尿素和硝酸钾按照质量比17:27复配；
步骤4）中，涂层厚度为0.5mm。
本发明具有以下有益技术效果：
1、吸热剂是一种溶解于水中吸收热量的物质，吸热剂的溶解度随温度的变化而变化，温度越高溶解度越大，吸收热量越多，温度低则溶解度小，吸收热量也少，药敷贴在使用时，接触到人体，利用人体的温度使药敷贴中水凝胶温度升高，从而加大了吸热剂在水凝胶中的溶解度，促进了吸热剂的溶解，吸热剂在溶解过程中吸收热量从而降低了药敷贴的温度，更进一步减缓水分的挥发，提高了药敷贴的时效性。
2、由于吸热剂吸收热量多少跟温度有关，当使用本发明产品时，人体发烧温度发生变化，会影响到药敷贴的温度，从而影响到吸热剂在水凝胶中的溶解度，因此吸热剂吸收的热量也在变化，药敷贴就会根据人体体温变化调节自身温度，从而达到一定的智能化。
3、本发明加入中药成分，起到安神补脑的效果，有助于睡眠，减少儿童的哭闹，保护儿童大脑。
具体实施方式
下面结合具体实例进一步说明本发明。
实施例1
将明胶和蒸馏水按照质量比8:92加入搅拌釜中，加热至85℃，搅拌至完全溶解，为产品A，降温至45℃为半凝胶状态，加入丙三醇、中药提取液、薄荷油和尿素，搅拌均匀，产品A、丙三醇、中药提取液、薄荷油和尿素的质量比为40:0.5:2:0.5:57，迅速冷却至室温，使之快速成为凝胶状态,用水凝胶在无纺布上涂布，涂层厚度为0.3mm，剪切得药敷贴半成品,在药敷贴上压上PET膜，包装得到药敷贴成品。
实施例2
将聚丙烯酰胺、明胶和蒸馏水按照质量比3:6:91加入搅拌釜中，加热至85℃，搅拌至完全溶解，产物称为产品A，降温至35℃，加入丙三醇、丙二醇、中药提取液、薄荷油、薄荷醇、尿素和硝酸钾，搅拌均匀，产品A、丙三醇、丙二醇、中药提取液、薄荷油、薄荷醇、尿素和硝酸钾的质量比为42:1:2:9:1:1:19:25，冷却至室温，使之成为凝胶状态,用水凝胶在无纺布上涂布，涂层厚度为0.5mm，剪切得药敷贴半成品,在药敷贴上压上PC膜，包装得到药敷贴成品。
实施例3
将聚丙烯酸钠、海藻酸钠、明胶和蒸馏水按照质量比5:1:4:90加入搅拌釜中，加热至85℃，搅拌至完全溶解，为产品A，降温至45℃为半凝胶状态，加入丙三醇、中药提取液、薄荷醇和尿素，搅拌均匀，产品A、丙三醇、中药提取液、薄荷醇和尿素的质量比为48:4:8:2:38，迅速冷却至室温，使之快速成为凝胶状态,用水凝胶在无纺布上涂布，涂层厚度为0.8mm，剪切得药敷贴半成品,在药敷贴上压上PC胶片，包装得到药敷贴成品。
实施例4
将聚丙烯酸钠、明胶和蒸馏水按照质量比7:4:89加入搅拌釜中，加热至82℃，搅拌至完全溶解，为产品A，降温至40℃为半凝胶状态，加入丙二醇、山梨醇、丙三醇、中药提取液、薄荷油和氯化铵，搅拌均匀，产品A、丙二醇、山梨醇、丙三醇、中药提取液、薄荷油和氯化铵的质量比为40:2:2:1:7:4:44，迅速冷却至室温，使之快速成为凝胶状态,用水凝胶在无纺布上涂布，涂层厚度为1mm，剪切得药敷贴半成品,在药敷贴上压上PC膜，包装得到药敷贴成品。
下面结合实验数据进一步说明本发明有益效果：
1一般资料
发明人于2014年8月至2016年3月间共收集450例儿童发烧，年纪在刚出生到6周岁之间，针对普通药敷贴（除未加吸热剂和中药提取液外，其它制作方法与实施例2相同）、实施例1、实施例2、实施例3、实施例4做效果比较。
1.2实验方法
将实验样品贴于患者额头。
1.3实验设计
将450例分别进行了5种药敷贴实验，每组90人。
2实验结果
普通药敷贴（除未加吸热剂和中药提取液外，其它制作方法与实施例2相同）调查满意度为65.4%；实施例1调查满意度为77.8%；实施例2调查满意度为89.5%；实施例3调查满意度为83.4%；实施例4调查满意度为82.7%。
3满意标准
贴上后儿童不哭闹，安静入睡，持续时间长，退热效果明显。
4讨论
发烧可能由多种原因引起，本发明对普通感冒引起的发烧有明显的效果，建议宝宝在发烧不超过38.5情况下，尽量采用物理降温，避免药物对宝宝的伤害，让发烧的儿童多睡觉，减少儿童的发烧带来的痛苦，并提高儿童自身的免疫力；如果持续高烧建议去当地医院就诊，以免耽误治疗。本发明对温度感应变化敏感，为了达到最佳效果，应保存在阴凉处，避免阳光照射。

Claims (4)

1.一种智能中药退热贴的制备方法，其特征在于按照以下步骤进行：
1）、将高分子物质和蒸馏水按照质量比3～15:85～97分别加入到搅拌釜中，加热至60～98℃，搅拌至完全溶解，产物称为产品A；
2）、将产品A降温至35～50℃，加入一定质量比的保湿剂、中药提取液、天然清凉剂和吸热剂，搅拌均匀；产品A、保湿剂、中药提取液、天然清凉剂和吸热剂的质量比为40～80:0.5～5:1～10:0.5～5:30～90；
3）、冷却至室温，得水凝胶；
4）、用水凝胶在背衬层上涂布，涂层厚度为0.25mm～1mm，剪切得药敷贴半成品；
5）、在药敷贴上压上网隔膜，得到智能中药退热贴；
所述高分子物质是聚丙烯酰胺、聚丙烯酸钠、海藻酸钠和明胶中的一种或任意比例的两种以上；
所述保湿剂是丙三醇、丙二醇和山梨醇中的一种或任意比例的两种以上；
所述中药提取液是五味子提取液、龙眼肉提取液、大枣提取液、柏子仁提取液、莲子提取液、茯苓提取液、防风提取液、大青叶提取液、四季青提取液、板蓝根提取液和连翘提取液提取液按照质量比5:5:3:6:7:10:2:3:6:9:1的组合物；
所述天然清凉剂是薄荷油和薄荷醇中的一种或任意比例的两种；
所述吸热剂是硝酸铵、氯化铵、硝酸钾和尿素中的一种或任意比例的两种以上。
2.如权利要求1所述的智能中药退热贴的制备方法，其特征在于：所述背衬层是无纺布。
3.如权利要求1所述的智能中药退热贴的制备方法，其特征在于：所述网隔膜是PET膜、PC胶片或PC膜。
4.如权利要求1所述的智能中药退热贴的制备方法，其特征在于：步骤1）中，高分子物质和蒸馏水按照质量比9:91，高分子物质是聚丙烯酰胺和明胶按照质量比3:6复配，加热至85℃；
步骤2）中，降温至35℃，产品A、保湿剂、中药提取液、天然清凉剂和吸热剂的质量比为42:3:9:2:44，其中保湿剂是丙三醇和丙二醇按照质量比1:2复配，天然清凉剂是薄荷油和薄荷醇按照质量比1:1复配，吸热剂是尿素和硝酸钾按照质量比17:27复配；
步骤4）中，涂层厚度为0.5mm。
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