CN105663675B - A kind of application of Chinese medicine composition in the drug that preparation has antifatigue effect - Google Patents
A kind of application of Chinese medicine composition in the drug that preparation has antifatigue effect Download PDFInfo
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- CN105663675B CN105663675B CN201610056552.3A CN201610056552A CN105663675B CN 105663675 B CN105663675 B CN 105663675B CN 201610056552 A CN201610056552 A CN 201610056552A CN 105663675 B CN105663675 B CN 105663675B
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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Abstract
Present invention relates particularly to a kind of Chinese medicine composition with antifatigue effect and preparation method thereof and purposes.The bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows: donkey hide 800-1800 parts by weight, Radix Glycyrrhizae 27-41 parts by weight, Rhizoma Chuanxiong 6-16 parts by weight, Rehmannia glutinosa 0.5-6.5 parts by weight, Radix Angelicae Sinensis 9-20 parts by weight, Radix Paeoniae Alba 3-15 parts by weight, Poria cocos 0.5-6.5 parts by weight, prepared RHIZOMA PINELLIZE without adju-vant 0.5-6.5 parts by weight, glutinous rehmannia 0.5-6.5 parts by weight, prepared RHIZOMA CYPERI with vinegar 0.5-2.5 parts by weight, radix polygonati officinalis 0.5-6.5 parts by weight, root of Dahurain angelica 0.5-6.5 parts by weight, dried orange peel 0.5-2.5 parts by weight, Radix Ophiopogonis 0.5-6.5 parts by weight, Radix Astragali 1-10 parts by weight；The Chinese medicine composition fully considers the channel tropism and nature and flavor of each Chinese medicine, and the proportion for selecting each Chinese medicine mutual, so that each Chinese medicine is cooperated, collective effect, to play antifatigue effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation method thereof with antifatigue effect
With purposes.
Background technique
Fatigue is one and is related to the comprehensive physiology course of many Physiology and biochemistry factors, is that human body is mental or physical exertion
A kind of normal physiological phenomenon necessarily occurred when to certain phase, it both indicated the original ability to work of body it is temporary under
Drop, and may be the tendency that body develops to sick and wounded state.Human body feels fatigue, although unlike cancer, heart disease etc. are come
Gesture is swift and violent, directly and promptly causes death, but it has been seriously affected as a kind of stealthy killer for endangering modern's health
The work and life of people considerably increases sub-health population quantity.When human body is chronically under fatigue state, can produce not old
It first declines and burnout syndrome, excessive fatigue even can accelerate death.
Chinese patent literature CN1475229A discloses antifatigue compound Chinese medicine prescription, raw material include: Radix Glycyrrhizae, Rhizoma Chuanxiong,
Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, radix polygonati officinalis, dried orange peel, Radix Ophiopogonis, Radix Astragali etc..However, above-mentioned Chinese medicine composition the disadvantages of there are complicated composition, from
And it limits its application.
Therefore, study novel therapeutic effect is good, toxic side effect is small, composition simply with antifatigue effect drug have
It is significant.
Summary of the invention
Therefore, the present invention provide a kind of therapeutic effect is good, toxic side effect is small, composition simply have antifatigue effect in
Drug composition, and then preparation method and purposes are provided.
In order to solve the above technical problems, the present invention is achieved through the following technical solutions:
The present invention provides a kind of Chinese medicine composition, and the bulk pharmaceutical chemicals composition of the Chinese medicine composition includes:
Donkey hide 800-1800 parts by weight, Radix Glycyrrhizae 27-41 parts by weight, Rhizoma Chuanxiong 6-16 parts by weight, Rehmannia glutinosa 0.5-6.5 weight
Part, Radix Angelicae Sinensis 9-20 parts by weight, Radix Paeoniae Alba 3-15 parts by weight, Poria cocos 0.5-6.5 parts by weight, prepared RHIZOMA PINELLIZE without adju-vant 0.5-6.5 parts by weight, glutinous rehmannia
0.5-6.5 parts by weight, prepared RHIZOMA CYPERI with vinegar 0.5-2.5 parts by weight, radix polygonati officinalis 0.5-6.5 parts by weight, root of Dahurain angelica 0.5-6.5 parts by weight, dried orange peel
0.5-2.5 parts by weight, Radix Ophiopogonis 0.5-6.5 parts by weight, Radix Astragali 1-10 parts by weight.
Preferably, the above-mentioned Chinese medicine composition of the present invention, the bulk pharmaceutical chemicals of the Chinese medicine composition, which form, includes:
Donkey hide 1000-1600 parts by weight, Radix Glycyrrhizae 30-38 parts by weight, Rhizoma Chuanxiong 8-14 parts by weight, Rehmannia glutinosa 1-5 parts by weight, when
Return 11-18 parts by weight, Radix Paeoniae Alba 5-12 parts by weight, Poria cocos 1-5 parts by weight, prepared RHIZOMA PINELLIZE without adju-vant 1-5 parts by weight, glutinous rehmannia 1-5 parts by weight, vinegar fragrant
Attached 1-2 parts by weight, radix polygonati officinalis 1-5 parts by weight, root of Dahurain angelica 1-5 parts by weight, dried orange peel 1-2 parts by weight, Radix Ophiopogonis 1-5 parts by weight, Radix Astragali 3-8 weight
Measure part.
It is further preferred that the above-mentioned Chinese medicine composition of the present invention, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include:
1300 parts by weight of donkey hide, 35 parts by weight of Radix Glycyrrhizae, 12 parts by weight of Rhizoma Chuanxiong, 3 parts by weight of Rehmannia glutinosa, 15 parts by weight of Radix Angelicae Sinensis,
9 parts by weight of Radix Paeoniae Alba, 3 parts by weight of Poria cocos, 3 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 3 parts by weight of glutinous rehmannia, 2 parts by weight of prepared RHIZOMA CYPERI with vinegar, 3 parts by weight of radix polygonati officinalis,
3 parts by weight of the root of Dahurain angelica, 2 parts by weight of dried orange peel, 3 parts by weight of Radix Ophiopogonis, 6 parts by weight of Radix Astragali；Or
1200 parts by weight of donkey hide, 37 parts by weight of Radix Glycyrrhizae, 13 parts by weight of Rhizoma Chuanxiong, 4 parts by weight of Rehmannia glutinosa, 17 parts by weight of Radix Angelicae Sinensis,
11 parts by weight of Radix Paeoniae Alba, 4 parts by weight of Poria cocos, 4 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 4 parts by weight of glutinous rehmannia, 1 parts by weight of prepared RHIZOMA CYPERI with vinegar, 4 weight of radix polygonati officinalis
Part, 4 parts by weight of the root of Dahurain angelica, 1 parts by weight of dried orange peel, 4 parts by weight of Radix Ophiopogonis, 7 parts by weight of Radix Astragali；Or
1400 parts by weight of donkey hide, 36 parts by weight of Radix Glycyrrhizae, 11 parts by weight of Rhizoma Chuanxiong, 2 parts by weight of Rehmannia glutinosa, 13 parts by weight of Radix Angelicae Sinensis,
8 parts by weight of Radix Paeoniae Alba, 2 parts by weight of Poria cocos, 2 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 2 parts by weight of glutinous rehmannia, 1 parts by weight of prepared RHIZOMA CYPERI with vinegar, 2 parts by weight of radix polygonati officinalis,
2 parts by weight of the root of Dahurain angelica, 1 parts by weight of dried orange peel, 2 parts by weight of Radix Ophiopogonis, 5 parts by weight of Radix Astragali；Or
1600 parts by weight of donkey hide, 38 parts by weight of Radix Glycyrrhizae, 14 parts by weight of Rhizoma Chuanxiong, 5 parts by weight of Rehmannia glutinosa, 18 parts by weight of Radix Angelicae Sinensis,
12 parts by weight of Radix Paeoniae Alba, 5 parts by weight of Poria cocos, 4 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 5 parts by weight of glutinous rehmannia, 2 parts by weight of prepared RHIZOMA CYPERI with vinegar, 5 weight of radix polygonati officinalis
Part, 5 parts by weight of the root of Dahurain angelica, 2 parts by weight of dried orange peel, 5 parts by weight of Radix Ophiopogonis, 8 parts by weight of Radix Astragali；Or
It is 1000 parts by weight of donkey hide, 30 parts by weight of Radix Glycyrrhizae, 8 parts by weight of Rhizoma Chuanxiong, 1 parts by weight of Rehmannia glutinosa, 11 parts by weight of Radix Angelicae Sinensis, white
It is 5 parts by weight of Chinese herbaceous peony, 1 parts by weight of Poria cocos, 1 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 1 parts by weight of glutinous rehmannia, 1 parts by weight of prepared RHIZOMA CYPERI with vinegar, 1 parts by weight of radix polygonati officinalis, white
1 parts by weight of the root of Dahurian angelica, 1 parts by weight of dried orange peel, 1 parts by weight of Radix Ophiopogonis, 3 parts by weight of Radix Astragali.
The present invention also provides the preparation methods of above-mentioned Chinese medicine composition, comprising the following steps:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar,
Radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water at least 1 time, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos,
Prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, 2 are added every time
The water of~20 times of weight amounts extracts 0.5~20 hour, filtering, and merging filtrate is stood, and concentration obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction at least 1 time, is added every time
The water of 2~20 times of weight amounts extracts 0.5~30 hour, filtering, merging filtrate, and suitable alum is added, and stirring is uniformly mixed,
It stands, concentration obtains concentrate, spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
Preferably, the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprising the following steps:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar,
Radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 1~5 time, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, clear
The tuber of pinellia, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, be added 4 every time~
The water of 16 times of weight amounts extracts 0.5~10 hour, filtering, and merging filtrate is stood, and concentration obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, adds water refluxing extraction extracting in water 1~5 time,
The water that 2~15 times of weight amounts are added every time extracts 0.5~20 hour, filtering, and suitable alum is added in merging filtrate, stirs, is mixed
It closes uniformly, stands, concentration obtains concentrate, spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprising the following steps:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar,
Radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, clear half
Summer, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, be added 8~12 the 1st time
The water of times of weight amount extracts 1~5 hour, and the water of the 2nd 6~10 times of weight amounts of addition extracts 0.5~4 hour, the 3rd addition 6
The water of~10 times of weight amounts extracts 0.5~2 hour, filtering, and merging filtrate stands, supernatant A is concentrated into relatively close at 50 DEG C
Degree is 1.15-1.40, obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st addition 6
The water of~10 times of weight amounts extracts 12~18 hours, and the water of the 2nd 6~10 times of weight amounts of addition extracts 10~16 hours, filtering,
Suitable alum is added in merging filtrate, and stirring is uniformly mixed, and stands, supernatant B, which is concentrated into relative density at 50 DEG C, is
1.03-1.12 obtains concentrate, spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprising the following steps:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar,
Radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, clear half
Summer, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, be added 9~11 the 1st time
The water of times of weight amount extracts 2~4 hours, and the water of the 2nd 7~9 times of weight amounts of addition extracts 1~3 hour, the 3rd addition 7~9
The water of times of weight amount extracts 0.5~1.5 hour, filtering, and merging filtrate stands, supernatant A is concentrated into relative density at 50 DEG C
For 1.15-1.40, clear cream is obtained, it is spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st addition 7
The water of~9 times of weight amounts extracts 14~16 hours, and the water of the 2nd 7~9 times of weight amounts of addition extracts 12~14 hours, filters, and closes
And filtrate, suitable alum is added, stirring is uniformly mixed, and is stood, and it is 1.03- that supernatant B, which is concentrated into relative density at 50 DEG C,
1.12, concentrate is obtained, it is spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprising the following steps:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar,
Radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, clear half
Summer, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 10 weights of addition
The water of amount times amount extracts 3 hours, and the water of the 2nd 8 times of weight amounts of addition extracts 2 hours, and the water of the 3rd 8 times of weight amounts of addition mentions
It takes 1 hour, filters, merging filtrate, stand, it is 1.35 that supernatant A, which is concentrated into relative density at 50 DEG C, obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st addition 8
The water of times of weight amount extracts 15 hours, and the water of the 2nd 8 times of weight amounts of addition extracts 13 hours, filtering, merging filtrate, is added suitable
The alum of amount, stirring are uniformly mixed, and are stood, and it is 1.07-1.09 that supernatant B, which is concentrated into relative density at 50 DEG C, must be concentrated
Liquid, it is spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
In being prepared the present invention also provides the preparation for including above-mentioned Chinese medicine composition or including above-mentioned preparation method
The preparation of drug composition,
The Chinese medicine composition is added customary adjuvant and clinically acceptable tablet, capsule is made according to common process
Agent, powder, mixture, pill, jelly, paste, granule, solution, syrup, suppository, aerosol or injection.
The customary adjuvant are as follows: filler, disintegrating agent, lubricant, stabilizer, adhesive, sweetener, corrigent, anti-corrosion
Agent, matrix etc..Filler includes: dextrin, maltodextrin, starch, pregelatinized starch, lactose, mannitol, chitin, crystallite fibre
Tie up element, sucrose etc.；Disintegrating agent includes: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, crosslinked polyethylene pyrroles
Alkanone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose are received；Lubricant includes: magnesium stearate, dodecyl sulphate
Sodium, talcum powder, silica etc.；Stabilizer includes: polyvinylpyrrolidone, microcrystalline cellulose, sodium carboxymethylcellulose, seaweed
Sour sodium, sucrose, agar, xanthan gum, pectin, hydroxypropyl methyl cellulose etc.；Adhesive includes: starch slurry, honey, polyethylene pyrrole
Pyrrolidone, hydroxypropyl methyl cellulose etc.；Sweetener includes: white granulated sugar, rock sugar, sucrose, fructose, glucose, saccharin sodium, A Si
It is Ba Tian, stevioside, honey element, neotame, Sucralose, acesulfame potassium, xylitol, maltose, maltitol, hydroxyl isomaltulose, sweet
Reveal sugar alcohol etc.；Corrigent includes: various sweeteners and essence；Preservative includes: parabens, benzoic acid, sodium benzoate, sorb
Acid and the fixed, eucalyptus oil of its esters, benzalkonium bromide, acetic acid chloroethene etc.；Matrix includes: PEG6000, PEG4000, insect wax etc..
The Chinese medicine composition that is prepared the present invention also provides above-mentioned Chinese medicine composition, above-mentioned preparation method or among the above
Application of the preparation of drug composition in the drug that preparation has antifatigue effect.
Technical solution of the present invention has the advantages that
The present invention has the Chinese medicine composition of antifatigue effect, fully considers the channel tropism and nature and flavor of each Chinese medicine, and selects each
The mutual proportion of Chinese medicine makes each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", collective effect, thus
Play antifatigue effect.
Specific embodiment
Technical solution of the present invention will be clearly and completely described below, it is clear that described embodiment is this hair
Bright a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not having
Every other embodiment obtained under the premise of creative work is made, shall fall within the protection scope of the present invention.
Embodiment 1
The bulk pharmaceutical chemicals of the present embodiment Chinese medicine composition form
Donkey hide 1300g, Radix Glycyrrhizae 35g, Rhizoma Chuanxiong 12g, Rehmannia glutinosa 3g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 9g, Poria cocos 3g, prepared RHIZOMA PINELLIZE without adju-vant 3g,
Yellow 3g, prepared RHIZOMA CYPERI with vinegar 2g, radix polygonati officinalis 3g, root of Dahurain angelica 3g, dried orange peel 2g, Radix Ophiopogonis 3g, Radix Astragali 6g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, the glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, jade of selected weight are taken
Bamboo, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 10 times of weight of addition
The water of amount extracts 3 hours, and the water of the 2nd 8 times of weight amounts of addition extracts 2 hours, and it is small that the water of the 3rd 8 times of weight amounts of addition extracts 1
When, filtering, merging filtrate is stood, and it is 1.35 that supernatant A, which is concentrated into relative density at 50 DEG C, obtains clear cream, spare；
(2) donkey hide for taking selected weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 8 weight of addition
The water of amount extracts 15 hours again, and the water of the 2nd 8 times of weight amounts of addition extracts 13 hours, filters, merging filtrate, is added suitable
Alum, stirring are uniformly mixed, and are stood, and it is 1.07-1.09 that supernatant B, which is concentrated into relative density at 50 DEG C, obtains concentrate, standby
With；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
The present embodiment Chinese medicine composition is added customary adjuvant and jelly is made according to common process.
Embodiment 2
The bulk pharmaceutical chemicals of the present embodiment Chinese medicine composition form
Donkey hide 1200g, Radix Glycyrrhizae 37g, Rhizoma Chuanxiong 13g, Rehmannia glutinosa 4g, Radix Angelicae Sinensis 17g, Radix Paeoniae Alba 11g, Poria cocos 4g, prepared RHIZOMA PINELLIZE without adju-vant 4g,
Yellow 4g, prepared RHIZOMA CYPERI with vinegar 1g, radix polygonati officinalis 4g, root of Dahurain angelica 4g, dried orange peel 1g, Radix Ophiopogonis 4g, Radix Astragali 7g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, the glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, jade of selected weight are taken
Bamboo, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 9 times of weight of addition
The water of amount extracts 4 hours, and the water of the 2nd 9 times of weight amounts of addition extracts 1 hour, and the water of the 3rd 7 times of weight amounts of addition extracts
1.5 hours, filtering, merging filtrate was stood, and it is 1.15-1.35 that supernatant A, which is concentrated into relative density at 50 DEG C, obtains clear cream, standby
With；
(2) donkey hide for taking selected weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 7 weight of addition
The water of amount extracts 16 hours again, and the water of the 2nd 9 times of weight amounts of addition extracts 12 hours, filters, merging filtrate, is added suitable
Alum, stirring are uniformly mixed, and are stood, and it is 1.03-1.09 that supernatant B, which is concentrated into relative density at 50 DEG C, obtains concentrate, standby
With；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
The present embodiment Chinese medicine composition is added customary adjuvant and capsule is made according to common process.
Embodiment 3
The bulk pharmaceutical chemicals of the present embodiment Chinese medicine composition form
Donkey hide 1400g, Radix Glycyrrhizae 36g, Rhizoma Chuanxiong 11g, Rehmannia glutinosa 2g, Radix Angelicae Sinensis 13g, Radix Paeoniae Alba 8g, Poria cocos 2g, prepared RHIZOMA PINELLIZE without adju-vant 2g,
Yellow 2g, prepared RHIZOMA CYPERI with vinegar 1g, radix polygonati officinalis 2g, root of Dahurain angelica 2g, dried orange peel 1g, Radix Ophiopogonis 2g, Radix Astragali 5g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, the glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, jade of selected weight are taken
Bamboo, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 11 times of weight of addition
The water of amount extracts 2 hours, and the water of the 2nd 7 times of weight amounts of addition extracts 3 hours, and the water of the 3rd 9 times of weight amounts of addition extracts 0.5
Hour, filtering, merging filtrate is stood, and it is 1.35-1.40 that supernatant A, which is concentrated into relative density at 50 DEG C, obtains clear cream, spare；
(2) donkey hide for taking selected weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 9 weight of addition
The water of amount extracts 14 hours again, and the water of the 2nd 7 times of weight amounts of addition extracts 14 hours, filters, merging filtrate, is added suitable
Alum, stirring are uniformly mixed, and are stood, and it is 1.09-1.12 that supernatant B, which is concentrated into relative density at 50 DEG C, obtains concentrate, standby
With；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
The present embodiment Chinese medicine composition is added customary adjuvant and tablet is made according to common process.
Embodiment 4
The bulk pharmaceutical chemicals of the present embodiment Chinese medicine composition form
Donkey hide 1600g, Radix Glycyrrhizae 38g, Rhizoma Chuanxiong 14g, Rehmannia glutinosa 5g, Radix Angelicae Sinensis 18g, Radix Paeoniae Alba 12g, Poria cocos 5g, prepared RHIZOMA PINELLIZE without adju-vant 4g,
Yellow 5g, prepared RHIZOMA CYPERI with vinegar 2g, radix polygonati officinalis 5g, root of Dahurain angelica 5g, dried orange peel 2g, Radix Ophiopogonis 5g, Radix Astragali 8g；
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, the glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, jade of selected weight are taken
Bamboo, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 8 times of weight of addition
The water of amount extracts 5 hours, and the water of the 2nd 6 times of weight amounts of addition extracts 4 hours, and the water of the 3rd 6 times of weight amounts of addition extracts 2
Hour, filtering, merging filtrate is stood, and it is 1.35-1.40 that supernatant A, which is concentrated into relative density at 50 DEG C, obtains clear cream, standby
With；
(2) donkey hide for taking selected weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 10 weights of addition
The water of amount times amount extracts 12 hours, and the water of the 2nd 10 times of weight amounts of addition extracts 10 hours, filtering, merging filtrate, is added appropriate
Alum, stirring is uniformly mixed, stands, and it is 1.03-1.09 that supernatant B, which is concentrated at 50 DEG C relative density, obtain concentrate,
It is spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
The present embodiment Chinese medicine composition is added customary adjuvant and capsule is made according to common process.
Embodiment 5
The bulk pharmaceutical chemicals of the present embodiment Chinese medicine composition form
Donkey hide 1000g, Radix Glycyrrhizae 30g, Rhizoma Chuanxiong 8g, Rehmannia glutinosa 1g, Radix Angelicae Sinensis 11g, Radix Paeoniae Alba 5g, Poria cocos 1g, prepared RHIZOMA PINELLIZE without adju-vant 1g, glutinous rehmannia
1g, prepared RHIZOMA CYPERI with vinegar 1g, radix polygonati officinalis 1g, root of Dahurain angelica 1g, dried orange peel 1g, Radix Ophiopogonis 1g, Radix Astragali 3g.
The preparation method of the Chinese medicine composition, comprising the following steps:
(1) Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, the glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, jade of selected weight are taken
Bamboo, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 12 times of weight of addition
The water of amount extracts 1 hour, and the water of the 2nd 10 times of weight amounts of addition extracts 0.5 hour, and the water of the 3rd 10 times of weight amounts of addition mentions
It takes 0.5 hour, filters, merging filtrate, stand, it is 1.15-1.35 that supernatant A, which is concentrated into relative density at 50 DEG C, is obtained clearly
Cream, it is spare；
(2) donkey hide for taking selected weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 6 weight of addition
The water of amount extracts 18 hours again, and the water of the 2nd 6 times of weight amounts of addition extracts 16 hours, filters, merging filtrate, is added suitable
Alum, stirring are uniformly mixed, and are stood, and it is 1.09-1.12 that supernatant B, which is concentrated into relative density at 50 DEG C, obtains concentrate, standby
With；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
The present embodiment Chinese medicine composition is added customary adjuvant and tablet is made according to common process.
Experimental exampleThe research of present composition antifatigue effect
1, experiment purpose
It is tested by mice burden swimming, research the traditional chinese medicine composition of the invention exhausts the shadow of time to mice burden swimming power
It rings, its antifatigue effect of preliminary assessment.
2, experimental material
2.1 for reagent object
Experimental group: the Chinese medicine composition prepared with embodiment 1 is 2 times/day for reagent object.
Control group: Chinese angelica blood supplementing ball (JiLin ZiXin Pharmacy Co., Ltd's production, ingredient: Radix Angelicae Sinensis and Radix Astragali), 2 times/
It.
2.2 experimental animals and raising situation
(1) experimental animal
Mouse, SPF grades, half male and half female, weight 18g-22g is purchased from Beijing Vital River Experimental Animals Technology Co., Ltd..
Licensing number: SCXK (capital) 2012-0001, quality certification number: 11400700104838.
(2) rearing conditions
Experimental animal feeding is in Ordinary Animal Lab, and fluorescent lamp lighting, in the 12h light and shade period, free water, diet are warm
22 DEG C ± 2 DEG C of degree, blow 6 times -10 times/h.
2.4 experimental material
Europe Asia WB388 electronic timer: Europe Asia trade (Shanghai) Co., Ltd..
3, experimental method
3.1 dosage
Experimental group low dose group: dosage is 1.4g/kg/ days；
Experimental group middle dose group: dosage is 2.7g/kg/ days；
Experimental group high dose group: dosage is 5.4g/kg/ days；
Control group: dosage is 1.8g/kg/ days.
3.2 medication
Administration route is oral gastric infusion, and gastric infusion volume is 20mL/kg weight mouse.
3.3 drugs are prepared
After accurate weighing is for reagent object, appropriate amount of deionized water is added to be configured to required concentration.
3.4 experimental method
ICR mouse 60, half male and half female, after 18~22 grams of weight, adaptive feeding 5~7 days, be randomly divided into model group,
Experimental group low dose group, experimental group middle dose group, experimental group high dose group and control group.In experimental group low dose group, experimental group
Dosage group, experimental group high dose group and control group each group give relative medicine, and model group gives distilled water, administered volume 20mL/
10g, after successive administration 14 days, 0.5 hour after the last administration, the galvanized wire of 7% weight of mouse tail root load, set 50cm ×
It swims in the glass jar of 50cm × 50cm, depth of water 30cm in cylinder, 25 DEG C ± 1 DEG C of water temperature.With mouse under water 10 seconds cannot on
The time exhausted for swimming power is floated, its influence for exhausting the time to mice burden swimming power is studied.
4, statistical method
Experimental data is with " mean+SD" indicate.Data first carry out homogeneity test of variance.Variance is neat
One-Way ANOVA method is selected to carry out each comparison among groups；Heterogeneity of variance selects t ' to examine and carries out comparison among groups.
5, experimental result
Specific experiment the results are shown in Table 1.
Table 1 exhausts the influence of time to mice burden swimming power
Compared with model group:*P<0.05
As shown in Table 1, compared with model group, the weight bearing of control group, experimental group high dose group, experimental group low dose group mouse
Swimming power, which exhausts the time, can significantly improve mouse, there is significant difference (equal P < 0.05).This shows prepared by the embodiment of the present invention 1
Chinese medicine composition have certain antifatigue effect.
To sum up, the present invention has the Chinese medicine composition of antifatigue effect, fully considers the channel tropism and nature and flavor of each Chinese medicine, and select
The mutual proportion of each Chinese medicine is selected, so that each Chinese medicine is cooperated according to the compatibility relationship of " monarch, minister, help, make ", collective effect,
To play antifatigue effect.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (9)
1. a kind of application of Chinese medicine composition in the drug that preparation has antifatigue effect, which is characterized in that the Chinese medicine group
Close the bulk pharmaceutical chemicals composition of object are as follows:
Donkey hide 800-1800 parts by weight, Radix Glycyrrhizae 27-41 parts by weight, Rhizoma Chuanxiong 6-16 parts by weight, Rehmannia glutinosa 0.5-6.5 parts by weight, when
Return 9-20 parts by weight, Radix Paeoniae Alba 3-15 parts by weight, Poria cocos 0.5-6.5 parts by weight, prepared RHIZOMA PINELLIZE without adju-vant 0.5-6.5 parts by weight, glutinous rehmannia 0.5-6.5
Parts by weight, prepared RHIZOMA CYPERI with vinegar 0.5-2.5 parts by weight, radix polygonati officinalis 0.5-6.5 parts by weight, root of Dahurain angelica 0.5-6.5 parts by weight, dried orange peel 0.5-2.5 weight
Measure part, Radix Ophiopogonis 0.5-6.5 parts by weight, Radix Astragali 1-10 parts by weight.
2. application according to claim 1, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows:
Donkey hide 1000-1600 parts by weight, Radix Glycyrrhizae 30-38 parts by weight, Rhizoma Chuanxiong 8-14 parts by weight, Rehmannia glutinosa 1-5 parts by weight, Radix Angelicae Sinensis
11-18 parts by weight, Radix Paeoniae Alba 5-12 parts by weight, Poria cocos 1-5 parts by weight, prepared RHIZOMA PINELLIZE without adju-vant 1-5 parts by weight, glutinous rehmannia 1-5 parts by weight, prepared RHIZOMA CYPERI with vinegar
1-2 parts by weight, radix polygonati officinalis 1-5 parts by weight, root of Dahurain angelica 1-5 parts by weight, dried orange peel 1-2 parts by weight, Radix Ophiopogonis 1-5 parts by weight, Radix Astragali 3-8 weight
Part.
3. application according to claim 2, which is characterized in that the bulk pharmaceutical chemicals of the Chinese medicine composition form are as follows:
1300 parts by weight of donkey hide, 35 parts by weight of Radix Glycyrrhizae, 12 parts by weight of Rhizoma Chuanxiong, 3 parts by weight of Rehmannia glutinosa, 15 parts by weight of Radix Angelicae Sinensis, Radix Paeoniae Alba 9
Parts by weight, 3 parts by weight of Poria cocos, 3 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 3 parts by weight of glutinous rehmannia, 2 parts by weight of prepared RHIZOMA CYPERI with vinegar, 3 parts by weight of radix polygonati officinalis, the root of Dahurain angelica 3
Parts by weight, 2 parts by weight of dried orange peel, 3 parts by weight of Radix Ophiopogonis, 6 parts by weight of Radix Astragali；Or
1200 parts by weight of donkey hide, 37 parts by weight of Radix Glycyrrhizae, 13 parts by weight of Rhizoma Chuanxiong, 4 parts by weight of Rehmannia glutinosa, 17 parts by weight of Radix Angelicae Sinensis, Radix Paeoniae Alba
11 parts by weight, 4 parts by weight of Poria cocos, 4 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 4 parts by weight of glutinous rehmannia, 1 parts by weight of prepared RHIZOMA CYPERI with vinegar, 4 parts by weight of radix polygonati officinalis, the root of Dahurain angelica
4 parts by weight, 1 parts by weight of dried orange peel, 4 parts by weight of Radix Ophiopogonis, 7 parts by weight of Radix Astragali；Or
1400 parts by weight of donkey hide, 36 parts by weight of Radix Glycyrrhizae, 11 parts by weight of Rhizoma Chuanxiong, 2 parts by weight of Rehmannia glutinosa, 13 parts by weight of Radix Angelicae Sinensis, Radix Paeoniae Alba 8
Parts by weight, 2 parts by weight of Poria cocos, 2 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 2 parts by weight of glutinous rehmannia, 1 parts by weight of prepared RHIZOMA CYPERI with vinegar, 2 parts by weight of radix polygonati officinalis, the root of Dahurain angelica 2
Parts by weight, 1 parts by weight of dried orange peel, 2 parts by weight of Radix Ophiopogonis, 5 parts by weight of Radix Astragali；Or
1600 parts by weight of donkey hide, 38 parts by weight of Radix Glycyrrhizae, 14 parts by weight of Rhizoma Chuanxiong, 5 parts by weight of Rehmannia glutinosa, 18 parts by weight of Radix Angelicae Sinensis, Radix Paeoniae Alba
12 parts by weight, 5 parts by weight of Poria cocos, 4 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 5 parts by weight of glutinous rehmannia, 2 parts by weight of prepared RHIZOMA CYPERI with vinegar, 5 parts by weight of radix polygonati officinalis, the root of Dahurain angelica
5 parts by weight, 2 parts by weight of dried orange peel, 5 parts by weight of Radix Ophiopogonis, 8 parts by weight of Radix Astragali；Or
1000 parts by weight of donkey hide, 30 parts by weight of Radix Glycyrrhizae, 8 parts by weight of Rhizoma Chuanxiong, 1 parts by weight of Rehmannia glutinosa, 11 parts by weight of Radix Angelicae Sinensis, Radix Paeoniae Alba 5
Parts by weight, 1 parts by weight of Poria cocos, 1 parts by weight of prepared RHIZOMA PINELLIZE without adju-vant, 1 parts by weight of glutinous rehmannia, 1 parts by weight of prepared RHIZOMA CYPERI with vinegar, 1 parts by weight of radix polygonati officinalis, the root of Dahurain angelica 1
Parts by weight, 1 parts by weight of dried orange peel, 1 parts by weight of Radix Ophiopogonis, 3 parts by weight of Radix Astragali.
4. application according to claim 1, which is characterized in that the preparation method of the Chinese medicine composition, including following step
It is rapid:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis,
The root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water at least 1 time, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, clear half
Summer, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, 2~20 are added every time
The water of times of weight amount extracts 0.5~20 hour, filtering, and merging filtrate is stood, and concentration obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, adds water refluxing extraction at least 1 time, it is added 2 every time~
The water of 20 times of weight amounts extracts 0.5~30 hour, filtering, merging filtrate, and suitable alum is added, and stirring is uniformly mixed, quiet
It sets, is concentrated, obtains concentrate, it is spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
5. application according to claim 4, which is characterized in that the preparation method of the Chinese medicine composition, including following step
It is rapid:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis,
The root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 1~5 time, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, 4~16 weight are added every time
The water of amount extracts 0.5~10 hour again, filtering, and merging filtrate is stood, and is concentrated, is obtained clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, adds water refluxing extraction extracting in water 1~5 time, every time
The water that 2~15 times of weight amounts are added extracts 0.5~20 hour, filtering, merging filtrate, and suitable alum is added, and stirring, mixing are equal
It is even, it stands, concentration obtains concentrate, spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
6. application according to claim 5, which is characterized in that the preparation method of the Chinese medicine composition, including following step
It is rapid:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis,
The root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Huang, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 8~12 weight of addition
The water of amount extracts 1~5 hour again, and the water of the 2nd 6~10 times of weight amounts of addition extracts 0.5~4 hour, the 3rd addition 6~10
The water of times of weight amount extracts 0.5~2 hour, filtering, and merging filtrate is stood, and supernatant A, which is concentrated into relative density at 50 DEG C, is
1.15-1.40 obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 6~10 weights of addition
The water of amount times amount extracts 12~18 hours, and the water of the 2nd 6~10 times of weight amounts of addition extracts 10~16 hours, and filtering merges filter
Suitable alum is added in liquid, and stirring is uniformly mixed, and stands, and it is 1.03- that supernatant B, which is concentrated into relative density at 50 DEG C,
1.12, concentrate is obtained, it is spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
7. application according to claim 6, which is characterized in that the preparation method of the Chinese medicine composition, including following step
It is rapid:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis,
The root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Huang, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 9~11 weight of addition
The water of amount extracts 2~4 hours again, and the water of the 2nd 7~9 times of weight amounts of addition extracts 1~3 hour, the 3rd 7~9 weight of addition
The water of amount extracts 0.5~1.5 hour again, filtering, and merging filtrate is stood, and supernatant A, which is concentrated into relative density at 50 DEG C, is
1.15-1.40 obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 7~9 weights of addition
The water of amount times amount extracts 14~16 hours, and the water of the 2nd 7~9 times of weight amounts of addition extracts 12~14 hours, and filtering merges filter
Suitable alum is added in liquid, and stirring is uniformly mixed, and stands, and it is 1.03- that supernatant B, which is concentrated into relative density at 50 DEG C,
1.12, concentrate is obtained, it is spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
8. application according to claim 7, which is characterized in that the preparation method of the Chinese medicine composition, including following step
It is rapid:
(1) take the Radix Glycyrrhizaes of selected parts by weight, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant, glutinous rehmannia, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis,
The root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba, Poria cocos, prepared RHIZOMA PINELLIZE without adju-vant,
Huang, prepared RHIZOMA CYPERI with vinegar, radix polygonati officinalis, the root of Dahurain angelica, dried orange peel, Radix Ophiopogonis and Radix Astragali mixture total weight on the basis of, the 1st 10 times of weight amounts of addition
Water extract 3 hours, the water of the 2nd 8 times of weight amounts of addition extracts 2 hours, and the water of the 3rd 8 times of weight amounts of addition extracts 1 small
When, filtering, merging filtrate is stood, and it is 1.35 that supernatant A, which is concentrated into relative density at 50 DEG C, obtains clear cream, spare；
(2) donkey hide for taking selected parts by weight is soaked in water at least 48 hours, is added water refluxing extraction 2 times, the 1st 8 times of weight of addition
The water of amount extracts 15 hours, and the water of the 2nd 8 times of weight amounts of addition extracts 13 hours, filtering, and merging filtrate is added suitable white
Alum, stirring are uniformly mixed, and are stood, and it is 1.07-1.09 that supernatant B, which is concentrated into relative density at 50 DEG C, obtains concentrate, spare；
(3) concentrate is filtered, is heated to reflux, the clear cream is then added, mix, stir evenly to get.
9. application according to claim 1-8, which is characterized in that customary adjuvant is added in the Chinese medicine composition,
According to common process, clinically acceptable tablet, capsule, powder, mixture, pill, jelly, paste, granule, molten is made
Liquor, syrup, suppository, aerosol or injection.
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| CN102895587A (en) * | 2012-09-14 | 2013-01-30 | 山东福胶集团东阿镇阿胶有限公司 | Ginseng donkey-hide gelatin and preparation method thereof |
| CN105596729A (en) * | 2016-01-27 | 2016-05-25 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with anoxia resistance effect and preparation method and application thereof |
| CN105616960A (en) * | 2016-01-27 | 2016-06-01 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with anti-anemia effect as well as preparation method and application thereof |
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| CN102895587A (en) * | 2012-09-14 | 2013-01-30 | 山东福胶集团东阿镇阿胶有限公司 | Ginseng donkey-hide gelatin and preparation method thereof |
| CN105596729A (en) * | 2016-01-27 | 2016-05-25 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with anoxia resistance effect and preparation method and application thereof |
| CN105616960A (en) * | 2016-01-27 | 2016-06-01 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition with anti-anemia effect as well as preparation method and application thereof |
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| Title |
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| 阿胶口服液药理实验的初步探讨;邢富强等;《中药新药与临床药理》;19911115;第2卷;第34-36页 |
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