CN105662514A - Fast ligator for small animal coronary artery - Google Patents

Abstract

The invention discloses a rapid ligation device for small animal coronary arteries, which comprises a fixing frame, a positioning outer bracket fixed around the heart, a positioning pointer and a ligation mechanism, and the positioning outer bracket, the positioning pointer and the ligation mechanism are respectively sleeved on the fixing frame in sequence , the positioning pointer is connected to the ligation mechanism and can move synchronously along the fixed frame; the positioning outer support includes a first positioning arm and a second positioning arm with adjustable relative positions for determining the position of the heart, for connecting the first positioning The first flexible part of the arm and the second positioning arm, the end of the positioning pointer is located at the highest point of the beating heart; the ligation mechanism includes a first ligation handle and a second ligation handle for ligation, for connecting the first ligation handle and The second flexible part of the second ligation handle; the upper end of the first ligation handle is provided with a ligation needle, and the upper end of the second ligation handle is provided with a needle slot; when the barb-shaped needle tip pierces the heart wall, it cooperates with the opposite needle slot.

Description

Small Animal Coronary Rapid Ligator

technical field

The invention relates to a rapid ligator for small animal coronary arteries.

Background technique

The incidence of coronary atherosclerotic heart disease is increasing year by year, and it has become one of the important diseases that threaten human health. The study of coronary heart disease has also become a hotspot at present, and the animal model of myocardial ischemia with coronary artery ligation is the basis of this kind of research. However, the myocardial ischemia model of coronary artery ligation has high requirements for the operator, especially when the coronary artery is ligated, novices often cannot find the coronary artery, and the success rate of ligation is low.

At present, the main method of coronary artery ligation is: manual ligation by the experimenter, that is, the experimenter uses traditional surgical methods to observe the direction of the coronary artery, and then uses a needle holder, tweezers and needle thread to perform manual ligation. Because the heart is always in a beating state, it is difficult for the operator to accurately grasp the timing of the needle, which often results in the operator not knowing when to start. In addition, after the needle thread passes through the heart wall, it cannot be pulled out quickly, so the ligation needle often stays on the heart, and then falls away with the beating of the heart, resulting in ligation failure. If ligated violently, it is easy to penetrate the ventricular wall, rupture the heart, and cause the death of the animal.

To sum up, the establishment of the traditional myocardial ischemia model currently has the problems of difficult operation, inconsistent coronary artery positioning and ligation range, and the ligation needle is easy to stay in the heart, resulting in ligation failure.

Contents of the invention

In order to overcome the existing problems in the establishment of myocardial ischemia models, such as difficult operation, inconsistent coronary artery positioning and ligation range, ligation needles are easy to indwell in the heart and cause ligation failure, etc., the present invention provides a rapid coronary ligation device for small animals.

The technical scheme adopted in the present invention is:

The rapid ligation device for coronary arteries for small animals is characterized in that it includes a fixing frame, a positioning outer bracket fixed around the heart, a positioning pointer, and a ligation mechanism, and the positioning outer bracket, the positioning pointer, and the ligation mechanism are respectively sleeved on the On the fixed frame, the positioning pointer is connected with the ligation mechanism and can move synchronously along the fixed frame;

The positioning outer bracket includes a first positioning arm and a second positioning arm whose relative positions are adjustable for determining the position of the heart, and a first flexible member for connecting the first positioning arm and the second positioning arm. The two ends of a flexible member reversely bypass the fixed frame to form a first ring set on the fixed frame, and the lower ends of the first positioning arm and the second positioning arm are connected with the two ends of the first flexible member respectively. connect;

The positioning pointer points to the middle part of the conus pulmonary artery and the left atrial appendage, and the end of the positioning pointer is located at the highest point of the beating heart;

The ligation mechanism includes a first ligation handle and a second ligation handle for ligation, a second flexible member for connecting the first ligation handle and the second ligation handle, and the two ends of the second flexible member are reversed Bypassing the fixing frame to form a set of second loops set on the fixing frame, the lower ends of the first ligation handle and the second ligation handle are respectively connected to the two ends of the second flexible member; the first ligation handle The upper end of the handle is provided with a ligation needle, and the upper end of the second ligation handle is provided with a needle groove; the top of the ligation needle has a barbed needle point, and the bottom of the needle groove has a glue for fixing the barbed needle point. When the barb-shaped needle tip pierces the heart wall, it cooperates with the opposite needle groove.

The upper ends of the first positioning arm and the second positioning arm are respectively provided with a first upper arc-shaped groove and a second upper arc-shaped groove with the same shape for positioning the heart position, and the first upper arc-shaped groove and the second upper arc-shaped groove The notches of the two upper arc-shaped grooves are opposite, and the shape of the notches matches the shape of the outer periphery of the heart; on the first positioning arm below the first upper arc-shaped groove, and below the second upper arc-shaped groove The second positioning arm is respectively provided with a first lower arc-shaped groove and a second lower arc-shaped groove with the same shape for positioning the heart position; the size of the first upper arc-shaped groove is larger than that of the first lower arc-shaped groove size.

A fan-shaped adjustment slot for adjusting the relative position between the first positioning arm and the second positioning arm is provided between the first positioning arm and the second positioning arm, and one end of the fan-shaped adjustment slot is fixed On the first positioning arm, the other end is detachably fixed on the second positioning arm by a screw, and the position between the first positioning arm and the second positioning arm is adjusted by changing the position of the screw in the fan-shaped adjustment slot. relative position.

A hollow circle is provided behind the ligature needle to prevent the ligature needle from retreating and to fix the ligature needle.

There is a cylindrical magnetic collar around the needle groove, and an rubber ring for fixing the barbed needle point is arranged at the bottom.

The fixing bracket is a column bracket.

The first ligation handle and the second ligation handle are respectively provided with anti-slip sleeves.

When in use, fix the positioning external bracket for coronary artery ligation around the heart, adjust the first positioning arm and the second positioning arm through the fan-shaped fixing slot according to the size of the heart, and adjust the positioning pointer to an appropriate position. When the heart beats and touches the positioning pointer , press the first and second ligation handles inward, and then tie the knot; after the ligation is completed, loosen the fan-shaped fixing groove and take out the ligation device.

In the establishment of animal models of myocardial ischemia, especially the ligation of the left anterior descending coronary artery, the invention can quickly and accurately ligate the coronary artery, and solve the problem that the ligation needle remains in the heart during the manual ligation process.

The beneficial effects of the present invention are reflected in:

1. Solve the problem that the ligation needle stays in the heart during coronary ligation, and solve the difficulties that cause the heart to bleed and rupture, lead to animal death, increase the cost of the experiment, and affect the progress of the experiment.

2. Solve the problem of accurately grasping the needle point (the time point when the ligation starts) in coronary artery ligation modeling; it can quickly determine the ligation position, determine the ligation depth and accurately determine the ligation start time.

3. Reduce the problem of inconsistent ligation depth and range caused by manual ligation.

4. The operation is simple, the success rate is high, and the trauma is small.

5. It can effectively reduce human operation errors, and does not require the operator to have skilled surgical skills. It is suitable for novices and beginners.

Description of drawings

Figure 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is an overall 3D side view of the present invention.

Fig. 3 is a schematic diagram of the structure of the positioning outer bracket of the present invention.

Fig. 4 is a schematic structural view of the ligation mechanism of the present invention.

Fig. 5 is a schematic diagram of the structure of the ligature needle of the present invention.

Fig. 6 is a schematic diagram of the structure of the positioning pointer in the present invention.

detailed description

Referring to Fig. 1 to Fig. 6, the rapid coronary ligation device for small animals includes a fixation frame 1, a positioning outer support 2 fixed around the heart, a positioning pointer 3 and a ligation mechanism 4, and the positioning outer support 2, positioning pointer 3 and The ligation mechanism 4 is respectively sleeved on the fixed frame 1 in turn, and the positioning pointer 3 is connected with the ligation mechanism 4 and can move synchronously along the fixed frame 1;

The positioning outer bracket 2 includes a first positioning arm 21 and a second positioning arm 22 that are adjustable in relative position for determining the position of the heart, and a first flexible member for connecting the first positioning arm 21 and the second positioning arm 22 23, the two ends of the first flexible member 23 reversely bypass the fixed frame to form a first ring set on the fixed frame, the lower ends of the first positioning arm 21 and the second positioning arm 22 respectively connected to both ends of the first flexible member 23;

The positioning pointer 3 points to the middle part of the conus pulmonary artery and the left atrial appendage, and the end of the positioning pointer 3 is located at the highest point of the beating heart;

The ligation mechanism 4 includes a first ligation handle 41 and a second ligation handle 42 for ligation, a second flexible member 43 for connecting the first ligation handle 41 and the second ligation handle 42, the second flexible The two ends of the member 43 go around the fixed frame in reverse to form a second ring set on the fixed frame. The lower ends of the first ligation handle 41 and the second ligation handle 42 are connected with the second flexible member 43 The two ends are connected; the upper end of the first ligation handle 41 is provided with a ligation needle 411, and the upper end of the second ligation handle 42 is provided with a needle groove 421; the top of the ligation needle 411 has a barbed needle point 4111 , the bottom of the needle groove 421 has an rubber ring for fixing the barb-shaped needle point, and cooperates with the opposite needle groove 421 when the barb-shaped needle point 4111 pierces the heart wall.

The upper ends of the first positioning arm 21 and the second positioning arm 22 are respectively provided with a first upper arc-shaped groove 211 and a second upper arc-shaped groove 221 for positioning the position of the heart. The notches of the arc-shaped groove 211 and the second upper arc-shaped groove 221 are opposite, and the shape of the notch matches the shape of the outer periphery of the heart; on the first positioning arm below the first upper arc-shaped groove, the first positioning arm The second positioning arm below the two upper arc-shaped grooves is respectively provided with a first lower arc-shaped groove 212 and a second lower arc-shaped groove 222 of the same shape for positioning the heart position; the size of the first upper arc-shaped groove greater than the size of the first lower arc groove.

Between the first positioning arm 21 and the second positioning arm 22, a fan-shaped adjustment slot 5 for adjusting the relative position between the first positioning arm and the second positioning arm is provided, and the fan-shaped adjustment slot 5 One end is fixed on the first positioning arm 21, and the other end is detachably fixed on the second positioning arm 22 by a screw, and the first positioning arm and the positioning arm are adjusted by changing the position of the screw in the fan-shaped adjustment groove. The relative position between the second positioning arms.

The back of the ligation needle 411 is provided with a hollow circle 4112 for preventing the ligation needle from retreating and fixing the ligation needle.

The needle groove 43 is surrounded by a cylindrical magnetic collar, and the bottom is provided with an rubber ring for fixing the barbed needle point.

The fixed frame 1 is a cylindrical support.

The first ligation handle 41 and the second ligation handle 42 are respectively provided with anti-slip sleeves 44 .

When in use, fix the positioning external bracket for coronary artery ligation around the heart, adjust the first positioning arm and the second positioning arm through the fan-shaped fixing slot according to the size of the heart, and adjust the positioning pointer to an appropriate position. When the heart beats and touches the positioning pointer , press the first and second ligation handles inward, and then tie the knot; after the ligation is completed, loosen the fan-shaped fixing groove and take out the ligation device.

The content described in the embodiments of this specification is only an enumeration of the implementation forms of the inventive concept. The protection scope of the present invention should not be regarded as limited to the specific forms stated in the embodiments. Equivalent technical means that a person can think of based on the concept of the present invention.

Claims (7)

1. The small animal rapid coronary artery ligation device is characterized in that: it comprises a fixing frame, a positioning external support fixed around the heart, a positioning pointer and a ligation mechanism, and the positioning external support, the positioning pointer and the ligation mechanism are respectively sleeved on the On the fixed frame, the positioning pointer is connected to the ligation mechanism and can move synchronously along the fixed frame; The positioning outer bracket includes a first positioning arm and a second positioning arm whose relative positions are adjustable for determining the position of the heart, and a first flexible member for connecting the first positioning arm and the second positioning arm. The two ends of a flexible member reversely bypass the fixed frame to form a first ring set on the fixed frame, and the lower ends of the first positioning arm and the second positioning arm are connected with the two ends of the first flexible member respectively. connect; The positioning pointer points to the middle part of the conus pulmonary artery and the left atrial appendage, and the end of the positioning pointer is located at the highest point of the beating heart; The ligation mechanism includes a first ligation handle and a second ligation handle for ligation, a second flexible member for connecting the first ligation handle and the second ligation handle, and the two ends of the second flexible member are reversed Bypassing the fixing frame to form a set of second loops set on the fixing frame, the lower ends of the first ligation handle and the second ligation handle are respectively connected to the two ends of the second flexible member; the first ligation handle The upper end of the handle is provided with a ligation needle, and the upper end of the second ligation handle is provided with a needle groove; the top of the ligation needle has a barbed needle point, and the bottom of the needle groove has a glue for fixing the barbed needle point. When the barb-shaped needle tip pierces the heart wall, it cooperates with the opposite needle groove. 2. The rapid coronary ligator for small animals according to claim 1, characterized in that: the upper ends of the first positioning arm and the second positioning arm are respectively provided with a first upper arc with the same shape for positioning the heart position shaped groove and the second upper arc-shaped groove, the notches of the first upper arc-shaped groove and the second upper arc-shaped groove are opposite, and the shape of the notch matches the shape of the outer periphery of the heart; the first upper arc-shaped groove The first positioning arm below the arc-shaped groove and the second positioning arm below the second upper arc-shaped groove are respectively provided with a first lower arc-shaped groove and a second lower arc-shaped groove with the same shape for locating the position of the heart. Groove; the size of the first upper arc-shaped groove is larger than the size of the first lower arc-shaped groove. 3. The rapid coronary ligator for small animals as claimed in claim 2, characterized in that: between the first positioning arm and the second positioning arm, there is a device for adjusting the first positioning arm and the second positioning arm. The relative position of the fan-shaped adjustment slot between the arms, one end of the fan-shaped adjustment slot is fixed on the first positioning arm, and the other end is detachably fixed on the second positioning arm by a screw. Change the position of the screw in the fan-shaped adjustment slot to adjust the relative position between the first positioning arm and the second positioning arm. 4 . The rapid coronary ligator for small animals according to claim 3 , wherein a hollow circle for preventing the ligating needle from retreating and fixing the ligating needle is provided behind the ligating needle. 5 . 5 . The rapid coronary ligator for small animals according to claim 4 , wherein a cylindrical magnetic collar is provided around the needle slot, and an apron for fixing the barb-shaped needle tip is provided at the bottom. 6 . The rapid coronary ligator for small animals according to claim 5 , wherein the fixing bracket is a cylindrical bracket. 7 . 7 . The rapid coronary ligator for small animals according to claim 6 , wherein anti-slip sleeves are respectively provided on the first ligation handle and the second ligation handle. 8 .