CN105662439B - It is exclusively used in mouse arterial blood sample acquisition device - Google Patents
It is exclusively used in mouse arterial blood sample acquisition device Download PDFInfo
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- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
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Abstract
本发明涉及一种专用于鼠动脉血样采集装置，包括血样抽取装置、穿刺部件以及针座套，穿刺部件设于针座套上，针座套与血样抽取装置连接，穿刺部件为细软导管。使用时将小鼠全身麻醉后，固定在鼠板上；使得颈总动脉分离并露出，在颈总动脉剪一与血管呈30‑45℃角的向心切口；将细软导管由切口向心脏方向插入动脉内，抽取所需量的动脉血。上述采血装置采用细软管穿插血管，不会穿透动脉壁，操作安全、简单方便，而且细软导管便于保留固定在实验动物身体上，方便反复采集动脉血。
The invention relates to a blood sample collection device specially used for mouse arteries, comprising a blood sample extraction device, a puncturing part and a needle seat cover. When using, the mice were under general anesthesia, and then fixed on the mouse plate; the common carotid artery was separated and exposed, and a centripetal incision was cut in the common carotid artery at an angle of 30-45 °C with the blood vessel; the thin soft catheter was directed from the incision to the heart. Insert the artery and draw the desired amount of arterial blood. The above-mentioned blood collection device adopts a thin flexible tube to penetrate the blood vessel, which will not penetrate the arterial wall, and is safe, simple and convenient to operate, and the thin flexible catheter is convenient to be retained and fixed on the body of the experimental animal, so as to facilitate the repeated collection of arterial blood.
Description
Technical field
The present invention relates to be exclusively used in mouse arterial blood sample acquisition device.
Background technique
Mouse has become at present in biomedical research to be studied most in widely used experimental animal and the world today
Detailed mammalian laboratory animals, be usually used in science of heredity and genetic disease, oncology, communicable disease, drug, immunology,
The research in the fields such as endocrine system disease, geratology.With being on the rise for global climate problem, correlative study confirms that atmosphere is dirty
Dye is close with the morbidity of respiratory disease, cardiovascular disease, and internal authority magazine JAMA in 2012 confirms that air pollution is painstaking effort
One risks and assumptions of pipe disease, therefore the research in terms of respiratory tract, angiocarpy is also more and more.It is copied with mouse
The animal models such as chronic bronchopneumonia, acute pulmonary edema, bronchial asthma, chronic pulmonary hypertension, pulmonary fibrosis, which become, to be ground
Study carefully the basis of respiratory disease mechanism.We are in the experiment for carrying out Respiratory Tract of Mice disease model, it is often necessary to adopt to mouse
Collect arterial blood and carries out arterial blood gas analysis.
Look back related literatures, we acquire rat aorta blood for blood gas analysis at present, it is most of be all by from
Break arteria coeliaca, then quick suction blood or detachment mouse right common carotid artery, or is pierced and lived with 1ml syringe needle
Body mouse heart aspirates arterial blood, or opens brooch thorn right ventricle blood sampling.The shortcomings that three kinds of methods: 1, for direct detachment or
Person's needle pierces arteria coeliaca and acquires artery method: mouse peritoneal artery is located at abdominal cavity rear, and position is deeper, need to sufficiently expose mouse abdomen
Chamber elapses intestinal tube, manifests posterior wall of abdomen, removes retroperitoneal adipose tissue, just visible abdominal aorta, so big wound behaviour
Make, will affect the respiratory function of mouse, and then influence the accuracy of rat aorta vim and vigour；Blood is quickly aspirated after detachment arteria coeliaca
Liquid, arterial blood are directly contacted with air, be will have a direct impact on the important vim and vigour such as partial pressure of oxygen, blood oxygen saturation, carbon dioxide partial pressure and are referred to
Target accuracy.2, puncture intravital mouse heart to syringe and adopt arterial blood disadvantage: 1. mouse heart is small, and heart rate 470-480 times/
Min, Culling heart blood is relatively difficult, and technical requirements are high, and mouse death rate is higher in operating process, is not suitable for having strictly arterial blood
It is required that experimental study；2. it cannot be guaranteed that it is entirely arterial blood that institute is collected, because the direction of inserting needle or operational issue can also adopt
Arteriovenous mixes blood out, and it is obviously abnormal to will cause art pO2 and oxygen saturation.3, split brooch pierces right ventricle: if opening chest
Primary dead blood sampling, one opens thoracic cavity, has completely cut through the respiratory function of mouse, before not acquiring arterial blood, arterial blood gas
Significant change can occur for index of correlation, influence the accuracy of experimental data.
To sum up, there are many deficiencies for the method that existing mouse arterial blood is used, while being used for the acquisition of mouse arterial blood sample
Carried out using conventional syringe, since mouse heart, artery etc. are smaller, technical requirements are high, in operating process mouse death rate compared with
The problems such as high.
Summary of the invention
Objects of the present invention: to overcome defect of the existing technology, the present invention provides a kind of blood specimen collection operation letter
Just, safety, small on mouse influence, blood sample interference is few, and testing result is accurately exclusively used in mouse arterial blood sample acquisition device.
To achieve the above object, the present invention provides the following technical scheme that
One kind being exclusively used in mouse arterial blood sample acquisition device, including blood sample draw-out device, lancet and means and needle stand set, punctures
Component is put on set on needle stand, and needle stand set is connect with blood sample draw-out device, it is characterised in that: the lancet and means are led for jewelry, expensive clothing and other valuables
Pipe.
Arterial blood sample acquisition device application method of the invention is notch to be formed on blood vessel, then soft conduit edge is cut
Mouth puncture into it is intravascular, can by blood sample draw-out device blood was collected operation.Traditional puncture of steel needles is substituted using soft conduit,
Due to the flexibility of soft conduit, blood vessel will not be penetrated in puncture process, guarantee that the stability of experimental animal (avoids mouse
It is dead), operation is more easy, and technical requirements are low, reduces the operating time；And soft conduit is fixed on experimental animal convenient for retaining
It is convenient to acquire arterial blood repeatedly on body.
Preferably, the blood sample draw-out device is the vacuum type blood sample draw-out device with vacuum degree.
Under above structure, blood sample draw-out device has vacuum degree, arterial blood sample ingress of air can be reduced to the greatest extent, to improve
Collected arterial blood sample degree of purity improves testing result accuracy.
Preferably, the blood sample draw-out device includes pipeline switching control valve, forevacuum aspirating syringe and blood drawing note
Emitter, the pipeline switching control valve include valve body, have the first pipe fitting, the second pipe fitting, third pipe fitting, valve on valve body
The spool that control pipe fitting is connected two-by-two is equipped in the valve chamber of body, spool is connected with the operating parts for driving the switching of its position, described
Blood-drawing syringe is removably inserted on the first pipe fitting, and forevacuum aspirating syringe is installed on the second pipe fitting,
The jewelry, expensive clothing and other valuables conduit is connected on third pipe fitting through needle stand set.
The blood sample draw-out device working principle of above structure are as follows: spool controls the first pipe fitting and is connected with the second pipe fitting,
It is connected between forevacuum aspirating syringe and blood-drawing syringe, using forevacuum aspirating syringe by blood-drawing syringe and pipeline
In switching control valve respective air aspirate, so that blood-drawing syringe be in forevacuum state, back valve core control the first pipe fitting with
The conducting of third pipe fitting can be drawn blood by blood-drawing syringe and soft conduit；Due to blood-drawing syringe and accordingly
Air in pipeline switching control valve is extracted out to form forevacuum by forevacuum aspirating syringe, so as to lower air to arterial blood
The influence of sample improves the degree of purity of sample, improves testing result accuracy.And since the arterial pressure of mouse is limited, adopt
It is extracted with arterial blood of the syringe to experimental animal, is aspirated by external force, it is reliable that blood sample extracts acquisition；And it injects
After device acquires blood sample, it is also more convenient that blood sample is placed in the operation on detection device in the later period.
Preferably, the spool includes the insert body that rotary dynamic seal is matched in valve chamber, and the is equipped in insert body
One duct, the second duct and third duct, the first duct, the second duct and third duct Single port are to run through insert body
The outer aperture on surface, the first duct, the second duct and third duct another port converge inside insert body and mutual connection,
Also there is the sealing surface that can block a wherein pipe fitting, sealing surface, the first duct, the second duct on the circumferential surface of the insert body
It is evenly distributed with third duct.
Under said structure design, by corresponding two pipe fittings being connected in needs in the outer aperture in two of them duct when operation
Locate, at the corresponding remaining pipe fitting of sealing surface, to realize control two of them pipe fitting connection, structure is simple, operation side
Just；And spool can be driven to the second pipe fitting, third pipe fitting conduction position, so that the present apparatus is in common blood sampling operation
Formula expands use scope, it can be achieved that double syringe is used in combination.
Preferably, first pipe fitting and third pipe fitting are located on same linear position, and the second pipe fitting is positioned at the
Between one pipe fitting and third pipe fitting.
Under said structure design, when operating the closing face closure third pipe fitting and the second pipe fitting of spool, position
Adjacent, operating distance is short, easy to operate.
Preferably, the operating parts includes the central part of corresponding insert body rotation center, central part laterally corresponding closing
The toggle arm in face, toggle arm radially extend.
Under said structure design, operating parts structure is simple, and toggle arm can indicate valve body closed position, and can be convenient for behaviour
Make.
Preferably, the soft conduit is connected with needle stand set, and needle stand is covered to be cooperated with the socket of third pipe fitting, outside needle stand set
Wall has been laterally extended interlocking lug, and the outer movable sleeve of third pipe fitting is equipped with lock tube, and third pipe fitting, which is equipped with, prevents lock tube from skidding off
Backstop convex ribs, backstop convex ribs and lock tube limit along third pipe fitting length direction backstop, and lock tube inner hole wall is equipped with spiral
Lock convex ribs, spiral locking convex ribs and interlocking lug backstop interlocking.
Under said structure design, soft conduit is detachably connected using needle stand set with pipeline switching control valve, when connection, general
Needle stand set is socketed on third pipe fitting, lock tube is operated, so that the spiral locking convex ribs in lock tube are affixed on interlocking lug, rotation lock
Set is engaged so that interlocking lug is screwed in locking convex ribs, thus reach by needle stand set locking on third pipe fitting, detachable,
Lock tube is reversely rotated, the locking covered to needle stand is released, needle stand set can be extracted；Guarantee that soft conduit is fixed reliable and detachable
It is easy to operate, it stays convenient for soft conduit on experimental animal.
Preferably, the needle stand, which is put on, is equipped with a pair in interlocking lug positioned opposite, and the lock tube inner hole wall is equipped with
Two spiral locking convex ribs, two spiral locking convex ribs distribute alternately, and form two helicla flutes, interlocking between two spiral locking convex ribs
Lug and two helicla flutes, which correspond, to be cooperated.
Under said structure design, two o'clock locking, the locking of needle stand pipe more firm stable are realized, and lock in double helix
Convex ribs design is lower to form two helicla flutes, and interlocking lug screws in two helicla flutes, and two spiral locking convex ribs are realized to interlocking lug
Both direction backstop locking on third pipe fitting length direction, the fixation of needle stand pipe are more solid and reliable.
Preferably, solid-state anticoagulation agent is placed in the channel of the needle stand set.
Under said structure design, solid-state anticoagulation agent can effectively prevent blood coagulation, and solid-state anticoagulation agent is put in needle stand set,
The blood sample extracted can be made to contact with anti-coagulants as early as possible, guarantee that the sample of blood drawing reaches technical requirements；On the other hand, solid-state
The placement location of anti-coagulants rationally, conveniently, will not impact the operation of other components, as blood sample draw-out device vacuumizes
Operation.
The invention will be further described below in conjunction with the accompanying drawings.
Detailed description of the invention
Fig. 1 is exclusively used in mouse arterial blood sample acquisition device structural schematic diagram for the specific embodiment of the invention one；
The spool and the structural representation after valve body decomposition that Fig. 2 is the pipeline switching control valve of the specific embodiment of the invention one
Figure；
Fig. 3 is the third pipe fitting and needle stand set cooperation schematic diagram of the specific embodiment of the invention one；
Fig. 4 is specific embodiment of the invention needle stand set (the soft conduit of band) schematic diagram of internal structure；
Fig. 5 is to be exclusively used in mouse arterial blood sample acquisition device structural schematic diagram in the specific embodiment of the invention two.
Specific embodiment
Referring to attached drawing 1 to attached drawing 4, one kind disclosed by the invention is exclusively used in mouse arterial blood sample acquisition device, including blood sample is taken out
Device 1, lancet and means 2 and needle stand set 21 are taken, lancet and means 2 are set on needle stand set 21, needle stand set 21 and blood sample draw-out device 1
Connection, the lancet and means 2 are soft conduit.PE pipe can be used in soft conduit, and application method is as follows, first by mouse systemic fiber crops
After liquor-saturated, it is fixed on mouse plate；Right side of mice skin of neck is cut off, separation separates sternohyoideus and chest along breastbone papillary muscle leading edge
Connective tissue between bone first shape flesh, the visible arteria carotis communis in scarlet beating by the tracheae of right side；Separation is always moved with row neck
The nerve of arteries and veins, isolates the arteria carotis communis of certain length (about 1cm) therewith, and it is spare that two silk threads are worn under it；What is isolated
The distal end of arteria carotis communis, in the proximal part of arteria carotis communis, is clamped artery with artery clamp, in two with silk thread by artery ligation
Between person, another spare silk thread is knotted, mouse plate is moved on into disecting microscope workbench in the following, in the knot close to distal end
Zha Chu cuts a centripetal notch with blood vessel in the 45 DEG C of angles 30-；The soft conduit 2 of blood-taking device is inserted from notch to heart direction
Enter intra-arterial, ligatured and fixed with spare silk thread, opens artery clamp, extract the desired amount of arterial blood, set blood sampling after extraction
Standby interior arterial blood seals blood sample immediately.It is small in the notch of mouse neck for the method for the past correlation acquisition arterial blood, it is right
Mouse is traumatic stress and to be influenced respiratory function small, and the blood sample of acquisition is pure arterial blood, and venous blood is avoided to be mixed into reality
The influence of result is tested, experimental data can be more accurately obtained, be punctured and inserted from arteriotomy using soft conduit in blood sampling apparatus
Enter artery, energy good match arteria carotis communis will not penetrate arterial wall, guarantee the security and stability of experimental animal, and operate letter
Just, technical requirements are low, and whole operation process only needs 3 to 4 minutes, shorten the time；And soft conduit is fixed on reality convenient for retaining
It tests on animal bodies, it is convenient to acquire arterial blood repeatedly.Conventional syringe Direct perforantes artery is avoided, and rat aorta is thinner, directly
It is punctured with syringe and enters artery, be easy to penetrate artery, thus cause animal blood loss dead, the poor problem of stability.
The blood sample draw-out device 1 is the vacuum type blood sample draw-out device with vacuum degree.Blood sample draw-out device has true
Reciprocal of duty cycle can reduce arterial blood sample ingress of air to the greatest extent, to improve collected arterial blood sample degree of purity, it is quasi- to improve testing result
True property.Structure as shown in Figure 5 can be used in it, cooperates double needle design using vacuum tube 91, wherein a syringe needle 92 is steel needle, just
In the soft rubber stopper 93 for being pierced into needle blank pipe, another head is the soft conduit 2, realizes blood drawing by the vacuum degree in vacuum tube,
But since the arterial pressure of mouse is small, there are stability and blood volume to be difficult to guarantee for the vacuum hemospasia of vacuum tube.Therefore it uses and such as divides into
Meter:
The blood sample draw-out device 1 includes pipeline switching control valve 11, forevacuum aspirating syringe 12 and blood drawing injection
Device 13, the pipeline switching control valve 11 include valve body 111, have the first pipe fitting 111, the second pipe fitting on valve body 110
112, third pipe fitting 113, the interior spool 114 for being equipped with control pipe fitting and being connected two-by-two of the valve chamber of valve body 110, spool 114 connect
There is the operating parts 115 for driving the switching of its position, the blood-drawing syringe 13 is removably inserted into the first pipe fitting 111
On, forevacuum aspirating syringe 12 is installed on the second pipe fitting 112, and forevacuum aspirating syringe 12 can be with the second pipe fitting
112 be detachable, or it is integrally formed, consider accessory processing, storage, ease of use etc., it is preferred to use detachably set
Meter, the jewelry, expensive clothing and other valuables conduit 2 are connected on third pipe fitting 113 through needle stand set 21, and needle stand set 21 can be fixedly connected with soft conduit 2
One is inseparable, and it is separable that plug connection can also be used.Blood sample draw-out device working principle are as follows: first pipe of the control of spool 114
Connector 111 and the second pipe fitting 112 are connected, and are connected between forevacuum aspirating syringe 12 and blood-drawing syringe 13, using pre- true
Empty aspirating syringe 12 aspirates respective air in blood-drawing syringe 13 and pipeline switching control valve 11, makes blood-drawing syringe 13
In forevacuum state, back valve core 114 control the first pipe fitting 111 and third pipe fitting 113 is connected, blood drawing note can be passed through
Emitter 13 and soft conduit 2 are drawn blood；Since the air in blood-drawing syringe and corresponding pipeline switching control valve is pre-
Vacuum suction syringe is extracted out to form forevacuum, so as to lower influence of the air to arterial blood sample, improves the pure of sample
Degree improves testing result accuracy.And since the arterial pressure of mouse is limited, using syringe to the arterial blood of experimental animal
It is extracted, is aspirated by external force, it is reliable that blood sample extracts acquisition.
Preferably, the spool 114 includes that rotary dynamic seal is matched with the insert body in valve chamber, is equipped in insert body
First duct 1141, the second duct 1142 and third duct 1143, the first duct 1141, the second duct 1142 and third duct
1143 Single ports are the outer aperture for running through insert body surface, the first duct 1141, the second duct 1142 and third duct
1143 another port converge inside insert body and mutual connection, and also having on the circumferential surface of the insert body can block wherein
The sealing surface of one pipe fitting, sealing surface, the first duct 1141, the second duct 1142 and third duct 1143 are evenly distributed.Institute
It states the first pipe fitting 111 to be located on same linear position with third pipe fitting 113, the second pipe fitting 112 is located at the first pipe fitting
Between 111 and third pipe fitting 113.Corresponding two pipes being connected in needs in the outer aperture in two of them duct are connect in operation
At head, at the corresponding remaining pipe fitting of sealing surface, to realize control two of them pipe fitting connection, structure is simple, operation
It is convenient；And spool can be driven to the second pipe fitting, third pipe fitting conduction position, so that the present apparatus is in common blood sampling operation
Formula expands use scope, it can be achieved that double syringe is used in combination.It is connect in the closing face closure third pipe fitting of operation spool and the second pipe
When head, position is adjacent, and operating distance is short, easy to operate.To guarantee that spool position switching is reliable in place, valve body and spool it
Between be equipped with shift structure, shift structure includes circumferentially distributed positioning protrusion and matched positioning groove, convex
It rises in insertion positioning groove and realizes that gear determines；Preferred positioning groove is set on spool, and positioning protrusion is set in valve body.
Certainly as the feasible scheme of the present invention, spool can longitudinally-moving cooperation in the valve chamber of valve body, two are set on spool
The channel that road is independently distributed along longitudinal direction, upper channel have a mouth of corresponding first pipe fitting and the second pipe fitting, and lower channel has pair
The mouth of the first pipe fitting and third pipe fitting is answered, there are two positions for spool tool, when vacuumizing, corresponding first pipe fitting of upper channel
It with the second pipe fitting position, switches it on, realizes vacuum pumping；Spool is pressed later, so that corresponding first pipe of lower channel connects
Head and third pipe fitting, switch it on, and realize blood drawing procedures.It can also be that two ducts are set on spool, two duct Single ports are
The outer aperture of spool face is penetrated through, two duct another port converge at connection in spool, i.e. two ducts form a folding shape channel,
Spool screws in valve body, outer apertures the first pipe fittings of correspondence of folding two of shape channel and third pipe fitting, and switches to pair
Answer the first pipe fitting and third pipe fitting.
For convenient for operating with, the operating parts 115 includes the central part 1151 of corresponding insert body rotation center, center
1151 side of portion is radially extended to the toggle arm 1152 for corresponding to sealing surface, toggle arm 1152.The central part of operating parts 115 is additionally provided with
The second instruction unit for corresponding to first instruction unit 1153 in outer aperture on the first duct 1141, corresponding to outer aperture on the second duct 1142
1154, on corresponding third duct 1143 outer aperture third instruction unit 1155, the first instruction unit 1153, the second instruction unit 1154,
Third instruction unit 1155 and toggle arm 1152 are spacedly distributed.Operating parts structure is simple, and toggle arm can indicate valve body close stance
It sets, and can be convenient for operation.
Wherein, needle stand set 21 can be integrally formed with blood sample draw-out device 1, can also be fixedly connected it is integrally inseparable,
It can cooperate for detachable.It is easy to use, the needle stand set 21 and the socket cooperation of third pipe fitting 113, the outer wall of needle stand set 21
It is laterally extended interlocking lug 211, the outer movable sleeve of third pipe fitting 113 is equipped with lock tube 14, and third pipe fitting 113 is equipped with and prevents
The backstop convex ribs 1131 that lock tube 14 skids off, backstop convex ribs 1131 and lock tube 14 are limited along 113 length direction backstop of third pipe fitting
Position, 14 inner hole wall of lock tube are equipped with spiral locking convex ribs 141, spiral locking convex ribs 141 and 211 backstop interlocking of interlocking lug.Carefully
Flexible conduit is detachably connected using needle stand set with pipeline switching control valve, and when connection, needle stand set is socketed on third pipe fitting,
Lock tube is operated, so that the spiral locking convex ribs in lock tube are affixed on interlocking lug, rotates lock tube, so that interlocking lug screws in and locking
Convex ribs occlusion, to reach by needle stand set locking on third pipe fitting, detachable reversely rotates lock tube, releases to needle stand set
Locking, needle stand set can be extracted；Guarantee that soft conduit is fixed reliable and detachable easy to operate, convenient for soft conduit stay in
On experimental animal.
Further, it is in interlocking lug 211a, 211b positioned opposite, the lock tube that the needle stand set 21, which is equipped with a pair of,
14 inner hole walls are equipped with two spiral locking convex ribs 141a, 141b, and two spiral locking convex ribs distribute alternately, and two spiral lockings are convex
Two helicla flute 142a, 142b, interlocking lug 211a, 211b and two helicla flute 142a, 142b are formed between muscle 141a, 141b one by one
Corresponding matching.It realizes two o'clock locking, the locking of needle stand pipe more firm stable, and is formed under double helix locking convex ribs design
Two helicla flutes, interlocking lug screw in two helicla flutes, and two spiral locking convex ribs are realized to interlocking lug third pipe fitting length
Both direction backstop locking on direction, the fixation of needle stand pipe are more solid and reliable.It is equipped with anti-sliding burr in lock tube outer surface, is convenient for
Rotation process lock tube.
Whether blood coagulation is to influence a key factor of Results of Blood-gas to arterial blood sample, to improve Results of Blood-gas
Accuracy, using anti-coagulants, such as heparin sodium.It is used to guarantee effect and being preferably applicable in equipment of the invention, in the needle
Solid-state anticoagulation agent 3 is placed in the channel of cover for seat 21.Solid-state anticoagulation agent is put in needle stand set, can make the blood extracted as early as possible
Sample is contacted with anti-coagulants, guarantees that the sample of blood drawing reaches technical requirements；On the other hand, solid-state anticoagulation agent placement location rationally,
It is convenient, the operation of other components will not be impacted, such as blood sample draw-out device vacuum pumping.
Claims (5)
1. one kind is exclusively used in mouse arterial blood sample acquisition device, including blood sample draw-out device, lancet and means and needle stand set, puncture portion
Part is put on set on needle stand, and needle stand set is connect with blood sample draw-out device, it is characterised in that: and the lancet and means are soft conduit,
The blood sample draw-out device includes pipeline switching control valve, forevacuum aspirating syringe and blood-drawing syringe, and the pipeline is cut
Changing control valve includes valve body, has the first pipe fitting, the second pipe fitting, third pipe fitting on valve body, is equipped in the valve chamber of valve body
The spool that control pipe fitting is connected two-by-two, is equipped with shift structure, shift structure includes circumferentially distributed between valve body and spool
Positioning protrusion and matched positioning groove, spool are connected with the operating parts for driving the switching of its position, the blood drawing injection
Device is removably inserted on the first pipe fitting, and forevacuum aspirating syringe is installed on the second pipe fitting, the jewelry, expensive clothing and other valuables
Conduit is connected on third pipe fitting through needle stand set, and the needle stand set cooperates with the socket of third pipe fitting, and the outer wall of needle stand set is horizontal
To being extended with interlocking lug, the outer movable sleeve of third pipe fitting is equipped with lock tube, third pipe fitting be equipped with prevent lock tube from skidding off only
It keeps off convex ribs, backstop convex ribs and lock tube to limit along third pipe fitting length direction backstop, lock tube inner hole wall is equipped with spiral locking
Convex ribs, spiral locking convex ribs and interlocking lug backstop interlocking, it is in interlocking lug positioned opposite that the needle stand, which puts on and is equipped with a pair of,
The lock tube inner hole wall is equipped with two spiral locking convex ribs, and two spiral locking convex ribs distribute alternately, two spiral locking convex ribs
Between form two helicla flutes, interlocking lug and two helicla flutes correspond and cooperate.
2. being exclusively used in mouse arterial blood sample acquisition device according to claim 1, it is characterised in that: the spool includes that rotation is dynamic
The insert body being matched in valve chamber is sealed, is equipped with the first duct, the second duct and third duct, the first hole in insert body
Road, the second duct and third duct Single port are the outer aperture for running through insert body surface, the first duct, the second duct and
Three ducts another port converge inside insert body and mutual connection, it can be blocked by also having on the circumferential surface of the insert body
In a pipe fitting sealing surface, sealing surface, the first duct, the second duct and third duct are evenly distributed.
3. being exclusively used in mouse arterial blood sample acquisition device according to claim 2, it is characterised in that: first pipe fitting and
Three pipe fittings are located on same linear position, and the second pipe fitting is between the first pipe fitting and third pipe fitting.
4. being exclusively used in mouse arterial blood sample acquisition device according to Claims 2 or 3, it is characterised in that: the operating parts includes
The central part of corresponding insert body rotation center, central part laterally correspond to the toggle arm of sealing surface, and toggle arm radially extends.
5. being exclusively used in mouse arterial blood sample acquisition device described according to claim 1 or 2 or 3, it is characterised in that: the needle stand set
Solid-state anticoagulation agent is placed in channel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610156259.4A CN105662439B (en) | 2016-03-18 | 2016-03-18 | It is exclusively used in mouse arterial blood sample acquisition device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610156259.4A CN105662439B (en) | 2016-03-18 | 2016-03-18 | It is exclusively used in mouse arterial blood sample acquisition device |
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| Publication Number | Publication Date |
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| CN105662439A CN105662439A (en) | 2016-06-15 |
| CN105662439B true CN105662439B (en) | 2019-01-18 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3634528B1 (en) | 2017-06-07 | 2023-06-07 | Shifamed Holdings, LLC | Intravascular fluid movement devices, systems, and methods of use |
| US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| WO2019152875A1 (en) | 2018-02-01 | 2019-08-08 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
| US12161857B2 (en) | 2018-07-31 | 2024-12-10 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| EP3860675A4 (en) | 2018-10-05 | 2022-07-13 | Shifamed Holdings, LLC | Intravascular blood pumps and methods of use |
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| CN105662439A (en) | 2016-06-15 |
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