[go: up one dir, main page]

CN105622562B - 一种治疗心脑血管疾病的药物组合物 - Google Patents

一种治疗心脑血管疾病的药物组合物 Download PDF

Info

Publication number
CN105622562B
CN105622562B CN201610114417.XA CN201610114417A CN105622562B CN 105622562 B CN105622562 B CN 105622562B CN 201610114417 A CN201610114417 A CN 201610114417A CN 105622562 B CN105622562 B CN 105622562B
Authority
CN
China
Prior art keywords
pharmaceutical composition
cerebrovascular disease
compound
group
treating cardiovascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201610114417.XA
Other languages
English (en)
Other versions
CN105622562A (zh
Inventor
张田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dongguan Asia Pharmaceutical Technology Co ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610114417.XA priority Critical patent/CN105622562B/zh
Publication of CN105622562A publication Critical patent/CN105622562A/zh
Application granted granted Critical
Publication of CN105622562B publication Critical patent/CN105622562B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明涉及一种治疗心脑血管疾病的药物组合物，所述药物组合物包含有效量的化合物和药学上可接受的载体，所述化合物具有下列结构：

Description

一种治疗心脑血管疾病的药物组合物
技术领域
本发明涉及医药领域，具体的说，本发明涉及一种治疗心脑血管疾病的药物组合物。
背景技术
心脑血管意外是一种严重威胁人类，特别是50岁以上中老年人健康的常见病，即使应用最先进、完善的治疗手段，仍可有50％以上的脑血管意外幸存者生活不能完全自理。全世界每年死于心脑血管疾病的人数高达1500万人，居各种死因首位。心脑血管疾病己成为人类死亡病因最高的头号杀手，也是人们健康的“无声凶煞”。心脑血管疾病主要原因就是血管壁平滑肌细胞非正常代谢造成的，血管组织和人体的其他组织在一定周期内完成新陈代谢的过程，但是由于新的细胞组织不能正常的形成，使血管壁本身存在“缺陷”因此就容易产生炎症血管收缩不畅，就像是一条破烂不堪的旧管道，随时都有阻塞或破裂的可能。
发明内容
本发明的目的在于提供一种治疗心脑血管疾病的药物组合物。
为了实现本发明的目的，本发明提供一种治疗心脑血管疾病的化合物，该化合物具有下列结构：
本发明还提供一种治疗心脑血管疾病的药物组合物，所述药物组合物包含有效量的化合物和药学上可接受的载体，所述化合物具有下列结构：
优选地，所述药学上可接受的载体为稀释剂、崩解剂、粘合剂、润滑剂、稳定剂或矫正剂。
优选地，所述稀释剂为糖衍生物、淀粉衍生物或纤维素衍生物。
优选地，所述稀释剂为乳糖。
优选地，所述药物组合物为散剂、微粒剂、颗粒剂、胶囊剂或片剂。
本发明还提供化合物在制备治疗心脑血管疾病的药物中的用途，该化合物具有下列结构：
本发明的化合物对于心脑血管疾病的效果显著，可以开发成临床上有效的新的药物组合物。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
目标化合物：
实验例
选取清洁级SD大鼠120只，体重180-220g，雌雄各半，将大鼠适应性喂养7天后，尾静脉取血，检测血脂水平，排除非健康实验动物对实验结果的影响，并根据体重、性别将大鼠随机分为4组后分笼饲养，分别为正常组、模型组、阳性药组、目标化合物组，每组30只。除了正常组给予普通饲料喂养外，其余各组大鼠首先给予维生素D370万IU/kg，3天内灌胃(正常组给予同等体积的生理盐水)，然后饲以高脂饲料(重量％)：胆固醇1％、丙基硫氧嘧啶0.61％，牛胆酸钠0.35％，猪油5％，基础饲料93.04％，饲养8周，以造成血脂异常动物模型。
造模后第3天开始给药，各组给药量如下：阳性药组，阿托伐他汀溶液0.09mg/ml，给予灌胃1mL/100g体重；目标化合物组，0.02g的目标化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重。1次/日，连续给药20d。
各组的大鼠用25％乌拉坦3ml/kg腹腔注射麻醉，30分钟后，将各组大鼠分别背部固定，剖开腹腔，腹主动脉取血5m1做血脂指标。腹主动脉取血5m1，离心机5000转/min离心10min，制备血清。采用天冬氨酸转氨酶(AST)活性检测试剂盒(Sigma-Aldrich)检测AST。
结果见下表。
组别 AST(U/L)
正常组 81.36±6.52
模型组 253.51±12.51
阳性药组 193.72±9.69
目标化合物组 216.52±11.06
与正常组比较，模型组及各治疗组AST含量均显著升高；与模型组比较，治疗后AST含量明显下降，说明均具有治疗效果。

Claims (1)

1.化合物在制备降低AST含量的药物中的用途，其特征在于，该化合物具有下列结构：
CN201610114417.XA 2016-03-01 2016-03-01 一种治疗心脑血管疾病的药物组合物 Active CN105622562B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610114417.XA CN105622562B (zh) 2016-03-01 2016-03-01 一种治疗心脑血管疾病的药物组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610114417.XA CN105622562B (zh) 2016-03-01 2016-03-01 一种治疗心脑血管疾病的药物组合物

Publications (2)

Publication Number Publication Date
CN105622562A CN105622562A (zh) 2016-06-01
CN105622562B true CN105622562B (zh) 2017-12-29

Family

ID=56037946

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610114417.XA Active CN105622562B (zh) 2016-03-01 2016-03-01 一种治疗心脑血管疾病的药物组合物

Country Status (1)

Country Link
CN (1) CN105622562B (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101475552A (zh) * 2009-02-09 2009-07-08 沈阳药科大学 羟基黄酮衍生物及其抗血小板聚集的用途
CN102285951A (zh) * 2011-09-13 2011-12-21 辽宁亿灵科创生物医药科技有限公司 木犀草素衍生物及其预防和治疗心血管疾病的用途
CN103408525A (zh) * 2013-08-13 2013-11-27 商洛学院 一种黄酮类化合物的合成方法及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101475552A (zh) * 2009-02-09 2009-07-08 沈阳药科大学 羟基黄酮衍生物及其抗血小板聚集的用途
CN102285951A (zh) * 2011-09-13 2011-12-21 辽宁亿灵科创生物医药科技有限公司 木犀草素衍生物及其预防和治疗心血管疾病的用途
CN103408525A (zh) * 2013-08-13 2013-11-27 商洛学院 一种黄酮类化合物的合成方法及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities;Wen Luo 等;《Bioorganic & Medicinal Chemistry》;20151218;第24卷;672-680 *

Also Published As

Publication number Publication date
CN105622562A (zh) 2016-06-01

Similar Documents

Publication Publication Date Title
AU2020202719B2 (en) Administration of tasimelteon under fasted conditions
CN105324114B (zh) 虾青素抗炎增效组合
WO2018019048A1 (zh) 含有叶黄素/叶黄素酯的组合物及其应用
WO2010081259A1 (zh) 含岩藻黄素提取物的组合物
KR20130041902A (ko) 성인 폴리글루코산체병（ａｐｂｄ）의 치료를 위한 트리헵타노인 식이
CN104667283B (zh) 一种治疗血脂异常和动脉粥样硬化的复方药物组合
CN110996933A (zh) 用于帕金森病的预防性和/或支持性治疗处理的药剂
KR101859166B1 (ko) 인삼이 함유된 한약재 추출물을 유효성분으로 함유하는 숙취 해소용 조성물
CN105622562B (zh) 一种治疗心脑血管疾病的药物组合物
CN105233288A (zh) 一种治疗或预防肥胖型高血压的药物组合物及其用途
CN104114165A (zh) 用于治疗憩室病的方法和组合物
WO2020020317A1 (zh) 二甲双胍复配组合物及其应用
CN104523693A (zh) 一种包含绿原酸的抗真菌复方制剂及其应用
US20230293477A1 (en) Method of treatment
CN106822123A (zh) 一种治疗心脑血管疾病的药物组合物
WO2011100668A4 (en) Methods and compositions of civamide to treat diseases of the intestines
CN105503723A (zh) 一种治疗冠心病的药物组合物
Masopust et al. Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease
TWI735658B (zh) 用於減少代謝症候群之組合物及其應用
CN105348217A (zh) 一种治疗高血脂的药物组合物
CN105616420A (zh) 一种降血脂的药物组合物
WO2023178840A1 (zh) 一种基于维生素k2提高老年人生命质量的药物组合物及其制备方法与应用
WO2025050793A1 (zh) 用于预防、改善及/或治疗肌肉疾病或肌肉失调的组合
CN107814823A (zh) 一种治疗糖尿病的化合物及其应用
Drake-Holland et al. The Effects of Felodipine on Left Ventricular Function in β-Blocked Patients

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Zhang Tian

Inventor before: Zhang Hongye

CB03 Change of inventor or designer information
TA01 Transfer of patent application right

Effective date of registration: 20171122

Address after: Qinyuan road 523000 Guangdong Songshan Lake City in Dongguan province the Great Wall family building 503 room 4

Applicant after: Zhang Tian

Address before: 052160 Yangzi Road, Shijiazhuang economic and Technological Development Zone, Shijiazhuang, Hebei Province, No. 88

Applicant before: Zhang Hongye

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20230717

Address after: No. 9, Hongmei Avenue, Hongmei Town, Dongguan, Guangdong 523000

Patentee after: Dongguan Asia Pharmaceutical Technology Co.,Ltd.

Address before: 523000 room 503, building 4, Changcheng family, Qinyuan Road, Songshan Lake, Dongguan City, Guangdong Province

Patentee before: Zhang Tian

TR01 Transfer of patent right