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CN105617019A - Effervescent granule composition containing dendrobium officinale ultrafine powder - Google Patents

Effervescent granule composition containing dendrobium officinale ultrafine powder Download PDF

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Publication number
CN105617019A
CN105617019A CN201510791200.8A CN201510791200A CN105617019A CN 105617019 A CN105617019 A CN 105617019A CN 201510791200 A CN201510791200 A CN 201510791200A CN 105617019 A CN105617019 A CN 105617019A
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Prior art keywords
acid
ultrafine powder
effervescent granule
dendrobium candidum
effervescent
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Chinese (zh)
Inventor
孙莺
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Beijing Heyuezhongkang Pharmaceutical Research And Development Co Ltd
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Beijing Heyuezhongkang Pharmaceutical Research And Development Co Ltd
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Priority to CN201510791200.8A priority Critical patent/CN105617019A/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract

The invention relates to an effervescent granule composition containing dendrobium officinale ultrafine powder and a preparation method of the effervescent granule composition as well as tablets containing the effervescent granule composition. The effervescent granule composition containing dendrobium officinale ultrafine powder comprises an acid-containing component and an air source component; effervescence occurs when the composition encounters water, so that the dispersing performance of the dendrobium officinale ultrafine powder in a medium is greatly improved, the absorption rate of effective constituents is improved, and the bioavailability is improved.

Description

Effervescent granule compositions containing dendrobium candidum ultrafine powder
Technical field
The present invention relates to food, functional food and medicine field, in particular to a kind of containing dendrobium candidum ultrafine powder can separately as or make functional food, medicine effervescent granule compositions and containing the medicine preparation of said composition.
Technical background
Herba Dendrobii (DendrobiumoffcinaleKimuraetMigo) is traditional rare Chinese medicine of China, and is written into " Chinese Pharmacopoeia " (version in 2010) as one of 5 kinds of medicinal dendrobiums. Herba Dendrobii is often used as medicine with fresh or dry stem, and multi-processing becomes dry product, and because the profile of dry product is quite commonly referred to as Herba Dendrobii like Herba Dendrobii extract.
China's Traditional Chinese medical theory is thought, Herba Dendrobii has the effects such as nourishing YIN and clearing away heat, reinforcing stomach reg fluid, slow down aging, is usually used in treatment or the conditioning of the symptom such as consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat. Modern study shows, Herba Dendrobii contains the superoxide dismutase (SOD) of greater activity, peroxidase (POD), catalase (CAT) isoreactivity chemical composition, has stronger oxidation resistance.
At present, Herba Dendrobii has been made into the form or the dosage form that are much convenient for people to use, such as capsule, tablet (element sheet, coated tablet, Film coated tablets), granule (electuary), powder, pill, sublimed preparation, teabag, tea-making, oral liquid, unguentum etc. But the utilization rate of its effective ingredient is but gone back and the expectation of people exists no small gap.
Improve the absorption rate of Chinese medicine as such in Herba Dendrobii or medicinal food materials, and prepare the convenient pharmaceutical dosage form used or functional food form, being always up the importance of modern Chinese medicine, health care and Nutritional studies, micronization technology is exactly the new technique of a kind of great potential therein. Modern study shows, a lot of plant medicinal active ingredients or nutritional labeling are primarily present in the Cytoplasm of its specific part cell, therefore, only could be absorbed after medicinal active ingredient or nutritional labeling dissolution cell wall and cell membrane. Generally there is due to medicinal plants comparatively hard cell wall, hinder effective dissolution of active component therein and nutritional labeling. The primary and foremost purpose of micronization technology seeks to break the cell wall of Chinese crude drug, is so conducive to the dissolution of effective ingredient therein, thus being absorbed and utilized by the body better. And ultramicronising technology breaks above-mentioned cell wall and cell membrane by the method for physical pulverization, improve absorbance, reduce and effectively make consumption, save medical material or food materials.
Modern analytical chemistry research shows, the main active of Herba Dendrobii is polysaccharide, and its content accounting is more than 20%, additionally, Herba Dendrobii is possibly together with the lot of traces such as stilbene class, alkaloid, aminoacid, trace element and the chemical composition being of value to health. Wall breaking technology is applied to Herba Dendrobii and can effectively facilitate above-mentioned active component and overflow from hard cell wall, improves the utilization rate of the Chinese medicine of this preciousness of Herba Dendrobii.
But, for Herba Dendrobii, only its breaking cellular wall can not be prepared satisfied application form, the main effective ingredient polysaccharide being primarily due to wherein to contain is water insoluble, in water, easily condense in bulk or become to stick with paste, and compact structure, it is difficult to it is scattered in water, hinder and take, reduce result of use.
Summary of the invention
How the present inventor prepares in research has high-absorbility and facilitates the various application forms containing ultramicronising Herba Dendrobii used in everyday, find during dosage form, although preparing the more traditional brewed or cooking method of obtained ultramicronising Herba Dendrobii as soaked according to breaking cellular wall physical pulverization method common at present, Baoshang, the utilization rate that can improve wherein active component to a certain extent such as grind, medicinal at equal dose, reinforced effects or reduce the consumption of material under equivalent efficacy in dietetic therapy, but in general, the effect of active component or nutritional labeling dissolution is not notable, especially main component activity mucopolysaccharide therein is still not readily dispersible in aqueous solution, but very easily formed densification agglomerate or flocculence material be attached to chamber wall, replace dissolving be not easy to desorb even across hot water repeatedly or cold water or hot cold water, dissolve or suspendible.
Additionally, the present inventor's comparative study micron physical is pulverized and the General Physics pulverization process impact on Herba Dendrobii antioxidation in vitro functional characteristic. Method is be respectively adopted antioxidation in vitro model 4 kinds different: hydroxyl radical free radical (OH), superoxide anion (O2-), nitrite ion (NO2-), DPPH check the oxidation resistance of dendrobium officinale powder. Result shows: dendrobium candidum ultrafine powder and common flour are to OH, O2-, NO2-, DPPH free radical be respectively provided with higher scavenging action, and clearance rate strengthens along with the increase of extracting solution mass concentration within the specific limits. But dendrobium candidum ultrafine powder is respectively provided with radical scavenging activity higher significantly relative to common flour in these 4 kinds of antioxidation in vitro models.
Hot water or warm water is added so that it dissolves or disperses being contained by above-mentioned dendrobium candidum ultrafine powder after common wall breaking technology wall breaking pulverization in the containers such as the cup of the materials such as porcelain used in everyday, rustless steel, glass, bowl and rushing, so that when drinking or swallow, it has been found that this is fairly cumbersome and is difficult to be properly done. Even if being repeatedly also difficult to water dissolution make the dendrobium candidum ultrafine powder in container be dissolved or dispersed in water, and owing to the gathering of wherein a large amount of polysaccharide is agglomerating, in bulk, also it is difficult to separate well the dendrobium candidum ultrafine powder of attached wall cohesion even with means such as knife and fork stirring, scrapings, causes the inconvenience of use and the waste of precious material.
In order to solve this application difficult problem caused because of intrinsic characteristic because of Herba Dendrobii, present inventor has performed systematic study, and achieve satisfied progress.
Dendrobium candidum ultrafine powder system is made effervescent granule compositions by the present invention, this granule includes acid source (A) and source of the gas (B) two parts, wherein acid source optional itself is nontoxic, after reaction also without the acid compound of noxious substance generation, especially organic acid, such as citric acid, tartaric acid, citric acid, fumaric acid, adipic acid, malic acid etc. Source of the gas is selected from any material nontoxic, that chance acid can decompose and produce gas, and available compound includes but not limited to sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate etc. The above-mentioned acid source in component A and the source of the gas in B component are pulverized accordingly all in accordance with needs, can be uniformly distributed in whole system. Component A and B component get final product initiating chamical reaction and discharge a certain amount of gas and cause effervescent effect when meeting water.
The effervescent granule compositions containing dendrobium candidum ultrafine powder obtained by the present invention shows good medium dispersion effect after contacting with water and effervescence occurs; make under consumption according to description of the present invention is determined; dendrobium candidum ultrafine powder is partly dissolved in a reservoir, part is suspended in the bubble in the water in container and in water layer with the form of fine particles or ultrafine dust, thus accomplishing substantially not attached wall or only a small amount of attached wall. Most of Herba Dendrobii to be taken disposable can be made when taking or drink to enter user oral cavity, thus farthest make use of material, decreasing waste, having promoted absorption, it is ensured that the performance of medicinal, nutrition or health-care effect.
Compositions containing dendrobium candidum ultrafine powder also can contain other active component, such as Semen Oroxyli, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, Radix Panacis Quinquefolii, Spica Prunellae, Semen Cassiae etc. The compound of they compositions has the specific aim that better keeps healthy, it is possible to for treatment or the physiological conditioning of different symptoms.
The invention also relates to prepare into preparation that is convenient and that use efficiently by above-mentioned dendrobium candidum ultrafine powder compositions, such as buccal tablet, effervescent tablet and oral cavity disintegration tablet. Heretofore described oral cavity disintegration tablet is the one of oral rapid solution drug-supplying system, this dosage form energy fater disintegration, when anhydrous and when not chewing saliva by means of patient also can realize good administration, be particularly suitable for old people and child and part disabled. Orally-disintegrating tablet is defined as " Tablet, OrallyDisintegrating " by FDA, and some professional magazines are referred to as " OrallyDisintergratingTablets, ODT ". Oral cavity disintegration tablet in the present invention meet " a kind of solid dosage forms containing medicine, when being placed on tongue can rapidly disintegrate, generally can several seconds��tens of seconds in complete. " definition.
In order to present disclosure is better described, the present invention is further detailed by we:
The present invention relates to a kind of effervescent granule compositions containing dendrobium candidum ultrafine powder, this effervescent granule compositions contains dendrobium candidum ultrafine powder, it is possibly together with at least one acid and at least one alkali that can produce gas, and the bronsted lowry acids and bases bronsted lowry wherein contained when this effervescent granule compositions meets water chemical reaction can occur and produces gas. Wherein said acid preferably organic acid, such as a kind in citric acid, tartaric acid, citric acid, fumaric acid, adipic acid, malic acid or the wherein combination of 2��3 kinds. The combination of in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, the calcium carbonate a kind or 2��3 kinds of wherein said alkali. Should containing effervescent granule compositions of dendrobium candidum ultrafine powder, the weight percentage of dendrobium candidum ultrafine powder therein preferably 3%��30%, preferred weight percentage is 5%��25%.
Above-mentioned composition, the alkali wherein contained and acid account for the weight percentage preferred acid about 2%��10% of whole effervescent granule compositions, alkali about 2%��10% respectively, and the equivalent of bronsted lowry acids and bases bronsted lowry is essentially identical.
In addition this effervescent granule compositions, it also can contain one or more in the dissolution dried object or wall breaking pulverization micropowder etc. of Semen Oroxyli, Flos Chrysanthemi, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Semen Cassiae.
A kind of method that the invention still further relates to effervescent granule compositions containing dendrobium candidum ultrafine powder, it is characterized in that its preparation is divided into step A and step B, wherein step A is the preparation granule containing dendrobium candidum ultrafine powder and acid, step B is the preparation granule containing dendrobium candidum ultrafine powder and alkali, after prepared by the granule of step A and step B, granule prepared by two steps ratio as required is packed and sealed, can be prepared by the effervescent granule compositions containing dendrobium candidum ultrafine powder.
Moreover, it relates to a kind of tablet, it contains the effervescent granule compositions of dendrobium candidum ultrafine powder of above-mentioned people one component, and this tablet can be, but not limited to be buccal tablet, effervescent tablet or oral cavity disintegration tablet.
Detailed description of the invention:
Specifically, the present invention contains the preparation of compositions of the superfine powder of Herba Dendrobii in two steps, to be fabricated to A group component and B group component respectively. Specifically include the part A containing acid and containing the part B of source of the gas, it is possible to part A and part B are packed respectively, it is also possible to by packaging together to part A and part B after the drying and when keeping the environment dried. Further, it is also possible to the part A and part B that are dried to certain standard are made tablet, such as buccal tablet or effervescent tablet etc.
With embodiment, its manufacturing process is described below.
Embodiment 1: prepare in a wet process and obtain the effervescent granule compositions containing Herba Dendrobii, Radix Panacis Quinquefolii superfine powder
Preparation method:
Preparation A group component:
Prepare dendrobium candidum ultrafine powder: rejected by foreign material in Herba Dendrobii and Radix Panacis Quinquefolii, through cleaning, drying, cutting, drying for standby. Above-mentioned material Roughpulverizer was pulverized 10 mesh sieves, then the raw material of coarse pulverization was carried out micronizing (FDV type ultrafine crusher, Taiwan You Qi company limited produces, lower same), obtained the super fine mixture of Herba Dendrobii and Radix Panacis Quinquefolii.
Granulate: the Herba Dendrobii of wall breaking pulverization and Radix Panacis Quinquefolii are proportionally added into appropriate lactose and lactic acid mixing, soft material made by the ethanol being added thereto to 90%, putting in trough type mixing machine, granulate through the 30 swing granules of purpose, the wet granular prepared is placed in convection oven and dries.
Granulate, screening: with upper strata 40 order, the vibration pelletizing machine of lower floor 80 order, by dried particle screening, was constructed to the granule of 40 order��80 mesh sieves.
In this way, component A is prepared.
Preparation B component:
Wall breaking pulverization: the foreign material in Herba Dendrobii and Radix Panacis Quinquefolii are rejected, through cleaning, drying, cutting, drying for standby. Above-mentioned material Roughpulverizer is pulverized 10 mesh sieves, then the raw material of coarse pulverization was carried out micronizing, obtain the super fine mixture of Herba Dendrobii and Radix Panacis Quinquefolii.
Granulate: the Herba Dendrobii of wall breaking pulverization and Radix Panacis Quinquefolii are proportionally added the mixing such as appropriate lactose and sodium bicarbonate; add 90% ethanol and make soft material; putting in trough type mixing machine, granulate through the oscillating granulator of 30 orders, the wet granular prepared is placed in convection oven and dries.
Granulate, screening: with upper strata 40 order, the vibration pelletizing machine of lower floor 80 order, by dried particle screening, was constructed to the granule of 40 order��80 mesh sieves.
As above, component B is prepared.
Packaging: mixed according to 1: 1 by said components A and component B, carry out pouch encapsulation, namely prepares compositions.
The effervescent granule compositions containing Herba Dendrobii and the superfine powder of Radix Panacis Quinquefolii prepared by embodiment 1 has the effect such as enhancing immunity, resisting fatigue.
Embodiment 2
The granule composite tabletting that component A in embodiment 1 and component B mixes with 1: 1 ratio is made tablet.
Embodiment 3: prepare and obtain the effervescent granule compositions of the superfine powder containing Herba Dendrobii, Semen Oroxyli, Flos Chrysanthemi in a wet process
Preparation method:
Prepared by component A:
Wall breaking pulverization: by Herba Dendrobii, Semen Oroxyli, Flos Chrysanthemi impurities removing, through cleaning, drying, cutting, drying for standby. Above-mentioned material Roughpulverizer is pulverized 10 mesh sieves, then the raw material of coarse pulverization was carried out micronizing, obtain the mixing ultra-micro powder containing Herba Dendrobii, Semen Oroxyli and Flos Chrysanthemi.
Granulate: press content ratio above by above-mentioned add lactose and lactic acid containing Herba Dendrobii, Semen Oroxyli, Flos Chrysanthemi ultra-micro powder, and mix homogeneously, soft material made by the ethanol being subsequently adding appropriate 90%, put in trough type mixing machine, granulating through the 30 swing granules of purpose, the wet granular prepared is placed in convection oven and dries.
Granulate, screening: with upper strata 40 order, the vibration pelletizing machine of lower floor 80 order, by dried particle screening, makes the granule between 40 order��80 orders, thus preparing component A.
Preparation B component:
Wall breaking pulverization: by Herba Dendrobii, Semen Oroxyli, Flos Chrysanthemi foreign material reject, through cleaning, drying, cutting, drying for standby. Above-mentioned material Roughpulverizer is pulverized 10 mesh sieves, then the raw material of coarse pulverization was carried out micronizing, obtain the ultra-micro powder mixture of Herba Dendrobii, Semen Oroxyli and Flos Chrysanthemi.
Granulate: the mixture of the above-mentioned ultra-micro powder containing Herba Dendrobii, Semen Oroxyli and Flos Chrysanthemi is proportionally added into appropriate lactose and sodium bicarbonate mixing, soft material made by the ethanol adding 90%, put in trough type mixing machine, granulating through the 30 swing granules of purpose, the wet granular prepared is placed in convection oven and dries.
Granulate, screening: with upper strata 40 order, the vibration pelletizing machine of lower floor 80 order, by dried particle screening, is made the granule between 40 order��80 orders, obtained component B.
Packaging: by component A and component B by 1: 1 mixing, carry out pouch encapsulation, namely prepares compositions.
Embodiment 3 compositions prepared containing compositions such as Herba Dendrobii has effects such as protecting throat sore throat relieving and looks improving and the skin nourishing.
Embodiment 4: the granule composite tabletting that the component A in embodiment 3 and component B mixes with 1: 1 ratio is made tablet.
Embodiment 5: prepare and obtain the effervescent granule compositions of the superfine powder containing Herba Dendrobii, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Flos Chrysanthemi, Semen Cassiae in a wet process
Preparation method:
Preparation A group component:
Wall breaking pulverization: by Herba Dendrobii, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Flos Chrysanthemi, Semen Cassiae foreign material reject, through cleaning, drying, cutting, drying for standby. Then by above-mentioned material according to crossing 10 mesh sieves with coarse powder pulverizer after pulverizing after proportioning mixing, then by the raw material of coarse pulverization through micronizing, the superfine powder mixture containing Herba Dendrobii, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Semen Cassiae is prepared.
Granulate: by wall breaking pulverization above prepare containing Herba Dendrobii, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Flos Chrysanthemi, Semen Cassiae superfine powder mixture be proportionally added into appropriate lactose and lactic acid mixing; soft material made by the ethanol adding 90%; put in trough type mixing machine; granulating through the oscillating granulator of 30 orders, the wet granular prepared is placed in convection oven and dries.
Granulate, screening: with upper strata 40 order, the vibration pelletizing machine of lower floor 80 order, by dried particle screening, is made the granule between 40 order��80 orders, namely obtained component A.
Preparation B group component:
Wall breaking pulverization: rejected by foreign material in Herba Dendrobii and Radix Panacis Quinquefolii, through cleaning, dry, cutting off, standby after drying; 10 mesh sieves are crossed after being pulverized by above-mentioned material Roughpulverizer; Then the raw material of coarse pulverization is carried out micronizing, obtain the mixture of active principles of Herba Dendrobii, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Flos Chrysanthemi, Semen Cassiae.
Granulate: the Herba Dendrobii of wall breaking pulverization and Radix Panacis Quinquefolii are proportionally added into appropriate lactose and sodium bicarbonate mixing; soft material made by the ethanol adding 90%; putting in trough type mixing machine, granulate through the oscillating granulator of 30 orders, the wet granular prepared is placed in convection oven and dries.
Granulate, screening: with upper strata 40 order, the vibration pelletizing machine of lower floor 80 order, by dried particle screening, makes granule between 40 order��80 orders.
Obtain component B.
Packaging: by component A and component B by 1: 1 mixing, carry out pouch encapsulation, namely prepares compositions.
The effervescent granule compositions containing compositions such as Herba Dendrobii obtained by embodiment 5 has effect of hypertension auxiliary treatment.
Embodiment 6: the granule composite tabletting that the component A in embodiment 5 and component B mixes with 1: 1 ratio is made tablet.
Embodiment 7: prepare with spray drying method and obtain the effervescent tablet containing Herba Dendrobii or buccal tablet
Spray drying parameters is arranged, air inducing: 25 DEG C-45 DEG C, heating: 45 DEG C-65 DEG C, compression 0.15-0.2MPa, flow velocity, 25-30 rev/min.
Inlet temperature is 46 DEG C, and leaving air temp is 28 DEG C, automatic 25 seconds steel gray cycles, the automatic 2 seconds steel gray time.
Spray drying parameters is arranged, air inducing: 25 DEG C-45 DEG C, heating: 45 DEG C-65 DEG C, compression 0.15-0.2MPa, flow velocity, 25-30 rev/min.
Inlet temperature is 46 DEG C, and leaving air temp is 28 DEG C, automatic 25 seconds steel gray cycles, the automatic 2 seconds steel gray time.
Spray-drying operation is convenient, and labor intensity is little, and automaticity is high, and efficiency is high, and speed is fast, and the time is short, and its product humidity is uniform, and end product is crisp granule, and dissolubility is good.
Preparation method: the granule sub-sieve that spray drying will be adopted in above-mentioned A, B component to prepare, it is 100% that precentagewise is added total amount sum, and granule, after being sufficiently stirred for mixing, is granulated after adding ethanol in proper amount and aqueous solution moistening, is pressed into the tablet of different size specification.
The Herba Dendrobii tablet finally given can be buccal tablet or effervescent tablet. Meeting saliva after buccal tablet entrance and change, mouthfeel is good, long shelf-life, is conducive to the human body overall absorption to Herba Dendrobii effective ingredient, is greatly improved the bioavailability of Herba Dendrobii. Effervescent tablet then can after entering water fater disintegration and dissolving or suspendible, be conducive to taking and absorption of human body. The above-mentioned tablet containing Herba Dendrobii micropowder can as medicine or coordinate other medicine drug combination to use.

Claims (10)

1. the effervescent granule compositions containing dendrobium candidum ultrafine powder, this effervescent granule compositions contains dendrobium candidum ultrafine powder, it is characterized in that, it is possibly together with at least one acid and at least one alkali that can produce gas, and the bronsted lowry acids and bases bronsted lowry wherein contained when this effervescent granule compositions meets water chemical reaction can occur and produces gas.
2. the effervescent granule compositions of claim 1, acid therein is organic acid.
3. the effervescent granule compositions of claim 2, the combination of in citric acid, tartaric acid, citric acid, fumaric acid, adipic acid, the malic acid a kind or wherein 2��3 kinds of acid therein.
4. the effervescent granule compositions of claim 1, the combination of in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, the calcium carbonate a kind or 2��3 kinds of alkali therein.
5. the effervescent granule compositions of claim 1, the weight percentage of dendrobium candidum ultrafine powder therein is 3%��30%.
6. the effervescent granule compositions of claim 5, the weight percentage of dendrobium candidum ultrafine powder therein is 5%��25%.
7. it is acid about 2%��10% that the effervescent granule compositions of any one of claim 1��6, the alkali wherein contained and acid account for the weight percentage of whole effervescent granule compositions respectively, alkali about 2%��10%, and the equivalent of bronsted lowry acids and bases bronsted lowry is essentially identical.
8. the effervescent granule compositions of any one of claim 1��6, it also can contain one or more in the dissolution dried object or wall breaking pulverization micropowder etc. of Semen Oroxyli, Flos Chrysanthemi, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Spica Prunellae, Semen Cassiae.
9. the method for the effervescent granule compositions containing dendrobium candidum ultrafine powder of any one preparing claim 1��8, it is characterized in that its preparation is divided into step A and step B, wherein step A is the preparation granule containing dendrobium candidum ultrafine powder and acid, step B is the preparation granule containing dendrobium candidum ultrafine powder and alkali, after prepared by the granule of step A and step B, granule prepared by two steps ratio as required is packed and sealed, can be prepared by the effervescent granule compositions containing dendrobium candidum ultrafine powder.
10. a tablet, it is characterised in that this tablet contains the effervescent granule compositions containing dendrobium candidum ultrafine powder of any one of claim 1��8, and this tablet can be the one in buccal tablet, effervescent tablet, oral cavity disintegration tablet.
CN201510791200.8A 2014-11-21 2015-11-18 Effervescent granule composition containing dendrobium officinale ultrafine powder Pending CN105617019A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108671148A (en) * 2018-05-02 2018-10-19 佛山科学技术学院 A kind of dendrobium candidum leaf effervescent and preparation method thereof
CN109380574A (en) * 2018-12-20 2019-02-26 神农架炎帝奇峰茶业集团有限公司 Dendrobium nobile chrysanthemum tea and preparation method thereof
CN109432303A (en) * 2018-11-29 2019-03-08 遵义医学院 A kind of effervescent tablet and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108671148A (en) * 2018-05-02 2018-10-19 佛山科学技术学院 A kind of dendrobium candidum leaf effervescent and preparation method thereof
CN109432303A (en) * 2018-11-29 2019-03-08 遵义医学院 A kind of effervescent tablet and preparation method thereof
CN109380574A (en) * 2018-12-20 2019-02-26 神农架炎帝奇峰茶业集团有限公司 Dendrobium nobile chrysanthemum tea and preparation method thereof

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Application publication date: 20160601