CN105557695A - Active ingredient composition - Google Patents
Active ingredient composition Download PDFInfo
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- CN105557695A CN105557695A CN201410546500.5A CN201410546500A CN105557695A CN 105557695 A CN105557695 A CN 105557695A CN 201410546500 A CN201410546500 A CN 201410546500A CN 105557695 A CN105557695 A CN 105557695A
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- Prior art keywords
- active ingredient
- dithianon
- isoprothiolane
- bactericidal composition
- ingredient compositions
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- 239000000203 mixture Substances 0.000 title claims abstract 31
- 239000004480 active ingredient Substances 0.000 title claims abstract 16
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract 16
- 239000005764 Dithianon Substances 0.000 claims abstract 9
- PYZSVQVRHDXQSL-UHFFFAOYSA-N dithianon Chemical compound S1C(C#N)=C(C#N)SC2=C1C(=O)C1=CC=CC=C1C2=O PYZSVQVRHDXQSL-UHFFFAOYSA-N 0.000 claims abstract 9
- UFHLMYOGRXOCSL-UHFFFAOYSA-N isoprothiolane Chemical compound CC(C)OC(=O)C(C(=O)OC(C)C)=C1SCCS1 UFHLMYOGRXOCSL-UHFFFAOYSA-N 0.000 claims abstract 9
- 201000010099 disease Diseases 0.000 claims abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 3
- 230000002265 prevention Effects 0.000 claims abstract 2
- 244000038559 crop plants Species 0.000 claims 2
- 239000000375 suspending agent Substances 0.000 claims 2
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000004562 water dispersible granule Substances 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the agricultural field, in particular to an active ingredient composition, and further relates to a bactericidal composition containing isoprothiolane and dithianon and application of the bactericidal composition. The active ingredient composition contains the active ingredients including isoprothiolane and dithianon, wherein the weight ratio of isoprothiolane to dithianon is 100:1-1:100. The invention further relates to the bactericidal composition containing the active ingredient composition and an auxiliary and/or a carrier which are/is acceptable in agriculture and the application of the bactericidal composition in prevention or control over agricultural diseases.
Description
Technical field
The present invention relates to agriculture field, be specifically related to a kind of active ingredient compositions.The invention still further relates to a kind of bactericidal composition and the application thereof that contain Isoprothiolane and dithianon.
Background technology
The control of agricultural disease is be concerned about the most and important problem in agricultural production always.The whole Growing season of crop nearly all can be subject to the invasion and attack of various disease.
Isoprothiolane (Isoprothiolane, CasRN.50512-35-1) is a kind of efficient systemic fungicide, and sterling is white crystals, fusing point 54 ~ 54.5 DEG C.In 20 DEG C of water, solvability is 48mg/L, is soluble in the organic solvents such as acetone, benzene, toluene, chloroform, dimethyl formamide, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, n-hexane.Isoprothiolane by each site absorption of crop, and can be accumulated to leaf portion tissue, thus plays drug effect, resistance of rainwater washing against, can be used for the centering crop pests such as control rice blast, rice sheath blight disease, culm rot and bacterial leaf-blight.
Dithianon (Dithianon, CasRN.3347-22-6) sterling is tan crystals, fusing point 225 DEG C.Be insoluble in water and most organic solvent.Dithianon has multiaction mechanism, by react with sulfur-containing group and interference cell is breathed and suppressed a series of fungal enzyme, finally causes disease dead, while the good prolection of tool, also has certain therapeutic activity.Can be used for various crop fruit tree and comprise a kind of fruit, such as apple, pear, etc. and drupe as apple, pears, peach, apricot, cherry, oranges and tangerines, grape etc., prevent and treat most crop and fruit diseases as scab, mildew disease, leaf spot, rust, anthracnose, shot hole, downy mildew, brown rot etc.
CN103734141A discloses a kind of Isoprothiolane and the composite agricultural chemicals suspension agent of own azoles alcohol, it comprises Isoprothiolane, own azoles alcohol, surfactant, ethylene glycol, attapulgite, cetanol, the pyridine of acetic acid chloroethene and water, described agricultural chemicals suspension agent, suspensibility is high, has strong Uptake and translocation effect.
CN103518723A discloses a kind of composition pesticide containing dithianon and Isoprothiolane, is mainly used in the fungal diseases such as control rice blast, effectively can delays the drug-fast generation of pathogen and development.
CN101755759A discloses a kind of bactericidal composition containing dithianon and Fluoxastrobin, wherein the percentage by weight of dithianon and Fluoxastrobin is 5 ~ 60: 40 ~ 1, described composition, for preventing and treating the multiple diseases on vegetables, is especially suitable for control vegetables anthracnose, downy mildew, powdery mildew.
CN103168782A discloses a kind of bactericidal composition containing dithianon and triazole class compounds, the weight ratio of the two is 5 ~ 78 ︰ 2 ~ 60, and described composition is mainly used in preventing and treating anthracnose, spot defoliation, scab, leaf spot, downy mildew.
Because the present environmental requirement to bactericide and economic requirement continue to improve, such as to the requirement of activity profile, toxicity, selectivity, rate of application, residue composition and favourable preparation feasibility, in addition owing to may have problems in such as drug resistance, in crop health, therefore, exploitation is better than the new bactericide of existing bactericide is in some aspects lasting task.
Summary of the invention
The object of the invention is to provide a kind of active ingredient compositions for above-mentioned weak point, to harmful fungoid and bacterium, there is good effect and solve the agricultural methods of problem and the composition of depressant dose rate and/or enhanced activity spectrum and/or drug resistance management.
The present inventor have passed through long-term research, find by Isoprothiolane and dithianon composite, can effectively prevent and treat various crop disease, Synergistic.Based on this discovery, inventor completes the present invention.
When the activity of two kinds or more compounds exceed be used alone time compound active time just there occurs synergistic function.
A kind of active ingredient compositions of the present invention takes following technical scheme to realize:
Therefore, one aspect of the present invention provides a kind of active ingredient compositions, and described active ingredient compositions contains Isoprothiolane and dithianon.
In aforesaid active principles in combination thing, the weight ratio of described Isoprothiolane and dithianon is 100:1 to 1:100, especially preferably 50:1 to 1:50, preferred 1:20-20:1, more preferably 1:10-10:1, and more preferably the scope of 1:5-5:1 is interior obtains synergistic function.
The present invention on the other hand provides a kind of bactericidal composition, and wherein said composition comprises active ingredient compositions described above, and agriculturally acceptable auxiliary agent and/or carrier.
Preferably, in above-mentioned a kind of bactericidal composition, the weight content of described active ingredient compositions in described bactericidal composition is 1wt.% to 80wt.%, preferably 5wt.% to 60wt.%, more preferably 10wt.% to 50wt.%.
Above-mentioned a kind of bactericidal composition is prepared into agriculturally acceptable any formulation, is wherein preferably prepared into suspending agent, suspended emulsion, seed coat agent, wetting powder, water dispersible granules, microcapsule suspending agent, coated granule, extrudes granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet etc.
Above-mentioned formulation is this area regular dosage form, its preparation method is well known to those skilled in the art, be prepared into agricultural agent used by above-mentioned various formulation and/or carrier and consumption thereof and be similarly well-known to those skilled in the art, these all can see such as " formulations of pesticide process technology " (Liu Bulin edits, the second edition).Auxiliary agent used and/or carrier such as include but not limited to solvent, cosolvent, emulsifier, dispersant, wetting agent, cyst material, adhesive, film forming agent, disintegrant, thickener, antifreezing agent, stabilizing agent, pH adjusting agent, warning colouration, filler and/or carrier etc.Those skilled in the art can select one or more auxiliary agents wherein and/or carrier.
Such as, when being prepared into suspending agent, following components by weight percent can be comprised: active component 1-80%, wetting agent 2-15%, dispersant 2-15%, thickener 1-5%, antifreezing agent 1-5%, defoamer 0.1-2%, water surplus;
When being prepared into suspended emulsion, following components by weight percent can be comprised: active component 1-80%, solvent 1-30%, emulsifier 2-15%, wetting agent 2-15%, dispersant 2-10%, thickener 1-5%, antifreezing agent 1-5%, defoamer 0.1-2%, water surplus;
When being prepared into wetting powder, following components by weight percent can be comprised: active component 1-80%, wetting agent 2-15%, dispersant 2-15%, filler surplus;
When being prepared into water dispersible granules, following components by weight percent can be comprised: active component 1-80%, wetting agent 2-15%, dispersant 2-15%, disintegrant 1-6%, adhesive 1-5%, filler surplus.
Wherein, in above-mentioned formula, described solvent can be selected: one or more in benzene,toluene,xylene, acetone, dimethyl formamide, dimethyl sulfoxide (DMSO), chloroform, carrene, cyclohexane, cyclohexanone, 1-METHYLPYRROLIDONE, methyl alcohol, ethanol, propyl alcohol, isopropyl alcohol, butanols, isobutanol, cyclohexanol, Propylene Glycol ether, ethohexadiol ether, benzinum, acetonitrile, paraffin, tetrahydronaphthalene, isophorone, soybean oil, cottonseed wet goods;
Described cosolvent can be selected: one or more in methyl alcohol, ethanol, isopropyl alcohol, n-butanol etc.;
Described emulsifier can be selected: lauryl sodium sulfate, neopelex, calcium dodecyl benzene sulfonate, thermally coupled distillation columns amine salt, castor oil polyoxyethylene ether phosphate amine salt, triphen ethyl phenol polyoxy ether phosphate amine salt, Polyoxyethylene fatty acid amides, Fixanol, alkyl isoquinolinium salt, dialkylmorpholinum salts, oleamide sulfonate, diisopropyl naphthalene sulfonate, lignosulfonates, naphthalenesulfonate formaldehyde condensation compound, styryl phenyl APEO, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, polyoxyethylene nonylphenol ether, fatty alcohol-polyoxyethylene ether, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene block polymer, alkyl phenol formaldehyde resin polyoxyethylene ether, Polyoxyethylene Sorbitol Fatty Acid Esters, sorbitan monostearate, sorbitan monostearate APEO, one or more in polyoxypropylene glycol mono fatty acid ester etc.,
Described dispersant can be selected: lignosulfonates, to hydroxyphenyl sodium lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylnaphthalene sulfonate, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, dodecyl trimethyl ammonium salt, alkyl dimethyl benzyl ammonium salt, two polyoxyethylene lauryl ether phosphate, styrene-maleic acid salt copolymer, aliphatic alcohol polyoxyvinethene phosphate, polyoxyethylene nonylphenol ether, glycerine fatty acid APEO, polyoxyethylene alkylaryl ether, polyoxyethylene lanolin alcohol, Polyoxyethylene Sorbitan acid esters, polyoxyethylene glyceryl mono fatty acid ester, one or more in alkylolamides and polyoxyethylene alkyl amine etc.,
Described wetting agent can be selected: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, isooctanol Disodium sulfosuccinate, oleoyl methyl sodium taurocholate, polyoxyethylene lauryl ether carboxylic acid sodium, sodium N-lauroyl sarcosinate, N-sodium lauroyl glutamate, dioctyl sulfosuccinate, polyoxyethylene alkylaryl ether phosphate ester salt, trisiloxanes APEO, triphenoethyl benzene phenol polyethenoxy ether, castor oil polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, alkylphenol-polyethenoxy gathers base ether formaldehyde condensation products, alkylphenol-polyethenoxy base ether phosphate, polyoxyethylene fatty acid ester, higher fatty acid ester, one or more in sorbitan aliphatic ester etc.,
Described adhesive can be selected: one or more in starch, polyvinylpyrrolidone, carboxymethyl cellulose, carboxyethyl cellulose, gelatin, gum Arabic, xanthans etc.;
Described film forming agent can be selected: one or more in polyvinyl alcohol, polyvinyl acetate, polyacrylamide, carboxymethyl cellulose, hydroxypropyl cellulose, gum Arabic, gelatin, xanthans, starch etc.;
Described disintegrant can be selected: one or more in urea, sodium sulphate, calcium sulphate, sodium bicarbonate, ammonium sulfate, magnesium chloride, sodium chloride etc.;
Described thickener can be selected: one or more in gum Arabic, xanthans, gelatin, polyvinyl alcohol, aluminium-magnesium silicate, sodium carboxymethylcellulose etc.;
Described defoamer can be selected: one or more in butylphosphoric acid ester, phosphoric acid isobutyl ester, n-octanol, silicone etc.;
Described antifreezing agent can be selected: be selected from ethylene glycol, propane diols, glycerine etc. one or more;
Described stabilizing agent can be selected: one or more in the soybean oil based trimethylene diamine of triphenyl phosphite, N-, dialkyl group succinate sulfonate, epoxychloropropane, butyl glycidyl ether etc.;
Described warning colouration can be selected: basic rhodamine, alkaline purple 10, alkalescence are purple 49, one or more in CI 45430, acid red 52, azogeramine 4, acid blue 9, acid yellow 23, alkali red 1:1 0, alkali red 1:1 08;
Described preservative can be selected: one or more in benzoic acid, Sodium Benzoate etc.;
Described pH adjusting agent can be selected: one or more in hydrochloric acid, calgon, sodium citrate, sodium bicarbonate, sodium hydroxide, hydrogen-oxygen agent, triethanolamine etc.;
Described filler and/or carrier can be selected: one or more in attapulgite, diatomite, kaolin, white carbon, bentonite, montmorillonite, calcium carbonate, zeolite, acid clay, carclazyte, pyrophyllite, talcum, calcite etc.
The present invention provides aforesaid active principles in combination thing or bactericidal composition for preventing or control the purposes of agricultural disease on the other hand.
The present invention also provides a kind of prevention or controls the method for agricultural disease, aforesaid active principles in combination thing or bactericidal composition is acted on the propagating materials of target useful plant, pathogenic bacteria or its environment, target useful plant.
Wherein, the target useful plant that inventive compound composition or bactericidal composition are suitable for includes but not limited to: paddy rice, wheat, corn, barley, rye, oat, Chinese sorghum, cotton, soybean, red bean, Kidney bean, peanut, buckwheat, beet, rape, sunflower, sugarcane, tobacco, eggplant, tomato, Chinese prickly ash, potato, custard squash, cucumber, pumpkin, watermelon, wax gourd, pumpkin, radish, root-mustard, Chinese cabbage, wild cabbage, leaf mustard, broccoli, cauliflower, burdock, garland chrysanthemum, jerusalem artichoke, romaine lettuce, shallot, onion, garlic, asparagus, carrot, caraway, celery, spinach, pea, Swiss chard, rape etc.The agricultural disease fungal pathogens that inventive compound composition or bactericidal composition are suitable for preventing and treating includes but not limited to:
Mastigomycotina fungi, the fungies such as such as knee Pseudomonas (Plasmodiophora), joint Chytridium (Physoderma), Saprolegnia (Saprolegnia), Achyla (Achlya), pythium (Pythium), Phytophthora (Phytophthora), Peronospora (Peronospora), Pseudoperonospora (Pseudoperonospora), Plasmopara (Plasmopara), Bremia (Bremia), Sclerospora (Sclerospora);
Zygomycotina fungi, the fungies such as such as rhizopus (Rhizopus), mucor (Mucor), Absidia (Absidia), Choanephora (Choanephora);
Ascomycotina fungi, such as Exoascus (Taphrina), Eurotiale (Eurotiales), aspergillus (Aspergillus), Penicillium (Penicillium), Blumeria (Blumeria), Sphaerotheca (Sphaerotheca), Podosphaera (Podosphaera, Erysiphe (Erysiphe), Microsphaera (Microsphaera), Uncinula (Uncinula), Phyllactinia (Phyllactinia), long beak shell belongs to (Ceratocystis), Gibberella (Gibberella), Valsa (Valsa), mycosphaerella (Mycosphaerella), ball Cuo Pseudomonas (Guignardia), Venturia (Venturia), chain sclerotinia sclerotiorum belongs to (Monilinia, Invisible element is Monilia), the fungies such as Sclerotinia (Sclerotinia),
Basidiomycotina fungi, such as Puccinia (Puccinia), glue Rust (Gymnosporangium), grid Rust (Melampsora), Phakopsora (Phakopsora), Ustilago (Ustilago), Tilletia (Tilletia), axle Ustilago (Sphacelotheca), belong to (Septobasidium), Exobasidium (Exobasidium) every load ear, lead fungi of dying belongs to the fungi such as (Thanatephorus), Armillaria (Armillaria);
Deuteromycotina fungi, such as Rhizoctonia (Rhizoctonia), sclerotium (Sclerotium), Monilia (Monilia), powder spore belongs to (Oidium), Botrytis (Botrytis), Ramularia (Ramularia), Pyricularia Sacc. (Pyricularia), Penicillium (Penicillium), aspergillus (Aspergillus), Verticillium (Verticillium, Cercospora (Cercospora), Alternaria, Cladosporium (Cladosporium), Fusicladium (Fusicladium), Drechslera (Drechslera), Bipolaris (Bipolaris), the diseases such as prominent navel Helminthosporium (Exserohilum).
Concrete, inventive compound composition or bactericidal composition are suitable for the concrete plant disease of preventing and treating and disease fungus includes but not limited to:
Rice disease: rice blast (grey pears spore (Pyriculariagrisea)), long compacted spore leaf spot (palace portion cochliobolus (Cochliobolusmiyabeanus)), banded sclerotial blight (Rhizoctonia solani Kuhn (Rhizoctoniasolani)) and bakanae disease (gibberella fujikuroi (Gibberellafujikuroi));
Barley, wheat, oat and rye disease: powdery mildew (standing grain powdery mildew (Blumeriagraminis)), head blight (F.graminearum schw (Fusariumgraminearum), oat sickle spore (F.avenacerum), machete sickle spore (F.culmorum), F.asiatricum, avenge rotten microtorr bacterium (Microdochiumnivale)), rust (bar shaped handle rest fungus (Pucciniastriiformis), puccinia graminis (P.graminis), wheat leaf rust germ (P.recondite), barley handle rest fungus (P.hordei)), snow blight (Typhulasp., Micronectriellanivalis), loose kernel smut (Ustilagotritici), bunt (Tilletia caries (Tilletiacaries)), eye spot (wheat Phyllostachys pubescens (Pseudocercosporellaherpotrichoides)), barley leaf blotch (rye beak spore (Rhynchosporiumsecalis)), wheat moire disease (wheat leaf blight bacterium (Septoriatritici)), glume blight (clever withered ball chamber bacterium (Leptosphaerianodorum)) and net blotch (PyrenophorateresDrechsler),
Maize diseases: the corn northern leaf blight (the prominent compacted spore bacterium (Exserohilumturcicum) of navel), corn southern leaf blight (Fusarium oxysporum (Bipolarismaydis)), corn rust (Puccina sorghi (Pucciniasorghi));
Tomato disease: early blight (rope Lan Shi rod method (Alternariasolani)), leaf mold (cladosporium fulvum (Cladosporiumfulvum)), late blight (phytophthora infestans (Phytophthorainfestans)), gray leaf spot (eggplant crawl handle mould (
stemphyliumsolani));
Cucumber disease: gray mold (Botrytis cinerea (Botrytiscinerea)), cucumber downy mildew (Pseudoperonospora Cuba artificial downy mildew (
pseudoperonosporacubensis)), powdery mildew of cucumber (monofilament shell powdery mildew (Sphaerothecafuliginea)), cucumber anthracnose (Curcurbitaceae thorn dish spore bacterium (
colletotrichumorbiculare));
Cotton disease: Fusariumsp wilt disease (Fusarium oxysporum (Fusariumoxysporum)), damping off (Rhizoctonia solani Kuhn (Rhizoctonia solani Kuhn (Rhizoctoniasolani)), verticillium wilt (dahlia wheel branch spore (Verticilliumdahlia));
Rape disease: stalk break (sclerotinite (Sclerotiniasclerotiorum)), black spot (black spot of cabbage rod method (Alternariabrassicae)), powdery mildew (Erysiphecichoracearum), balck shank (Leptosphaeriamaculans);
Eggplant disease: brown spot (brown line Phomopsis (Phomopsisvexans)) and powdery mildew (Erysiphecichoracearum);
Brassicaceous vegetable disease: interlinkage bag belongs to leaf spot (Alternariajaponica), Leucoplakia (overgrown with weeds bluish white pinta bacterium (Cercosporellabrassicae)), club root (plasmodiophora brassicae (Plasmodiophorabrassicae)) and downy mildew (Peronospora parasitic (Peronosporaparasitica));
Shallot disease: rust (green onion handle rest fungus (Pucciniaallii));
Beans disease: purple seed pinta (Kikuchi tail spore (Cercosporakikuchii), scab circle spore belongs to shot hole (Elsinoeglycines), pod blight and cane blight (Diaporthephaseolorumvar.sojae), rust (Phakopsorapachyrhizi), stem rot (soybean phytophthora (Phytophthorasojae)), gray mold (Botrytis cinerea (Botrytiscinerea), stalk break (Sclerotiniasclerotiorum),
Kidney bean disease: gray mold (Botrytis cinerea (Botrytiscinerea), stalk break (Sclerotiniasclerotiorum), anthracnose (Colletotrichumlindemthianum);
Peanut disease: leaf spot (ball seat tail spore bacterium (Cercosporapersonata)), brown leaf spot (peanut tail spore bacterium (Cercosporaarachidicola)) and southern blight (Sclerotium rolfsii (Sclerotiumrolfsii));
Beet disease: Cercospora leaf spot (beet tail spore (Cercosporabeticola)), leaf blight (Thanatephoruscucumeris), root rot (Aphanomycescochlioides);
Pea disease: powdery mildew (pea powdery mildew (Erysiphepisi));
Potato disease: early blight (rope Lan Shi rod method (Alternariasolani)), late blight (phytophthora infestans (Phytophthorainfestans)), pink rot (Phytophthoraerythroseptica), powdery scab (Spongosporasubterraneanf.sp.subterranea) and rhizoctonia disease (Rhizoctoniasolani);
Tobacco diseases: brown spot (long handle rod method (Alternarialongipes)), powdery mildew (two spore powdery mildews (Erysiphecichoracearum)), anthracnose (Colletotrichumtabacum), downy mildew (peronospora tabacina (Peronosporatabacina)) and late blight (Phytophthoranicotianae).
Term " propagating materials of target useful plant " is interpreted as referring to all plant parts having fertility, such as seed, fruit, stem tuber or kernel or plant cutting.
Reactive compound Isoprothiolane and dithianon can be used simultaneously, or use respectively, or sequential application, and order during separate administration is on the nothing impact usually of the result of control.
Active ingredient compositions of the present invention or bactericidal composition are used it by usual manner, such as carry out watering, spray, atomizing, broadcast sowing, dust, and as solution, the water solube powder of process seed, the water solube powder of process earth of the process powder of dry seed, dry mixing powder, moist seed dressing, wet-mixing kind, slurries seed dressing, process seed, or by formation shell etc.
When using active ingredient compositions of the present invention or bactericidal composition,
During-usual process plant parts, the rate of application of active ingredient compositions is generally 0.1 to 10000g/ha, is preferably 10 to 1000g/ha;
During seed dressing, the rate of application of active ingredient compositions is 0.001 to 50g/kg seed, is preferably 0.01 to 10g/kg seed;
-for soil treatment: the rate of application of active ingredient compositions is generally 0.1-10000g/ha, preferred 1-5000g/ha.
Above-mentioned dosage is only general exemplary dose, and actual those skilled in the art can according to actual conditions and needs when using, especially according to pending plant or the character of crop and the seriousness adjustment rate of application of germ.
A kind of bactericidal composition of the present invention, has good effect to harmful fungoid and bacterium and solves agricultural methods and the composition of the problem of depressant dose rate and/or enhanced activity spectrum and/or drug resistance management.
A kind of bactericidal composition of the present invention by Isoprothiolane and dithianon composite, can effectively prevent and treat various crop disease, there is Synergistic.When the activity of two kinds or more compounds exceed be used alone time compound active time just there occurs synergistic function.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described, but does not limit the invention to these embodiments.One skilled in the art would recognize that all alternatives, improvement project and the equivalents that present invention encompasses and may comprise in Claims scope.
(1) example of formulations
In following example of formulations, unless otherwise indicated, described percentage is all weight percentage.
embodiment 110% Isoprothiolane+50% dithianon water-dispersion granule
Formula consists of: Isoprothiolane 10%, dithianon 50%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 10%, trisiloxanes APEO 5%, ammonium sulfate 5%, gum Arabic 5%, bentonite surplus;
Preparation method is: the above-mentioned each component taking formula ratio respectively, and mixed, granulation, obtained water dispersible granules.
embodiment 225% Isoprothiolane+5% dithianon water-dispersion granule
Formula consists of: Isoprothiolane 25%, dithianon 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, castor oil polyoxyethylene ether 8%, ammonium sulfate 5%, xanthans 5%, kaolin surplus;
Preparation method is: the above-mentioned each component taking formula ratio respectively, and mixed, granulation, obtained water dispersible granules.
embodiment 320% Isoprothiolane+2% dithianon suspending agent
Formula consists of: Isoprothiolane 20%, dithianon 2%, to hydroxyphenyl sodium lignin sulfonate 9%, triphenoethyl benzene phenol polyethenoxy ether 5%, gum Arabic 5%, ethylene glycol 5%, silicone 0.5%, water surplus;
Preparation method is: the above-mentioned each component taking formula ratio, by ultramicro grinding method, and obtained suspending agent.
embodiment 42% Isoprothiolane+20% dithianon suspending agent
Formula consists of: Isoprothiolane 2%, dithianon 20%, polyoxyethylene glyceryl mono fatty acid ester 9%, oleoyl methyl sodium taurocholate 7%, gum Arabic 5%, ethylene glycol 5%, silicone 0.5%, water surplus;
Preparation method is: the above-mentioned each component taking formula ratio, by ultramicro grinding method, and obtained suspending agent.
embodiment 540% Isoprothiolane+2% dithianon wetting powder
Formula consists of: Isoprothiolane 40%, dithianon 2%, polyoxyethylene alkyl amine 12%, alkylphenol-polyethenoxy gather base ether formaldehyde condensation products 6%, kaolin surplus;
Preparation method is: the above-mentioned each component taking formula ratio, and is mixed, grinds, pulverizes, obtained wetting powder.
embodiment 62% Isoprothiolane+40% dithianon wetting powder
Formula consists of: Isoprothiolane 2%, dithianon 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, polyoxyethylene alkylaryl ether phosphate 8%, kaolin surplus;
Preparation method is: the above-mentioned each component taking formula ratio, and is mixed, grinds, pulverizes, obtained wetting powder.
embodiment 710% Isoprothiolane+0.1% dithianon suspended emulsion
Formula consists of: Isoprothiolane 10%, dithianon 0.1%, dimethyl sulfoxide (DMSO) 8%, neopelex 6%, dodecyl trimethyl ammonium salt 4%, fatty alcohol-polyoxyethylene ether 5%, gum Arabic 3%, glycerine 4%, n-octanol 0.5%, water surplus;
Preparation method is: preparation method is: the Isoprothiolane of formula ratio, solvent, emulsifier, antifreezing agent, thickener, defoamer and suitable quantity of water are mixed, obtain aqueous emulsion; The dithianon of formula ratio, dispersant, wetting agent and suitable quantity of water mixed and carries out sand milling, obtaining suspension; The water of above-mentioned aqueous emulsion, suspension and surplus is mixed, stirs, obtain suspended emulsion.
embodiment 80.1% Isoprothiolane+10% dithianon suspended emulsion
Formula consists of: Isoprothiolane 0.1%, dithianon 10%, acetone 1%, neopelex 4%, polyoxyethylene nonylphenol ether 6%, N-sodium lauroyl glutamate 4%, gum Arabic 5%, glycerine 4%, n-octanol 0.5%, water surplus;
Preparation method is: preparation method is: the Isoprothiolane of formula ratio, solvent, emulsifier, antifreezing agent, thickener, defoamer and suitable quantity of water are mixed, obtain aqueous emulsion; The dithianon of formula ratio, dispersant, wetting agent and suitable quantity of water mixed and carries out sand milling, obtaining suspension; The water of above-mentioned aqueous emulsion, suspension and surplus is mixed, stirs, obtain suspended emulsion.
embodiment 91% Isoprothiolane+50% dithianon microcapsule suspension-suspendinagent agent
By poly methylene poly phenyl poly isocyanate (PAPI), Isoprothiolane and SOLVESSO
tM200 oil phases formed add containing ATLOX
tMin the aqueous solution of 4913, form emulsion.Then heat and be incubated 50
ocatalyst reaction is added 2 hours under C.The microcapsules of Isoprothiolane is obtained after cooling.
ATLOX
tM4913, dispersant LFH, defoamer, urea, dithianon and water mix in proportion, and through sand milling, are prepared into suspending agent.
The microcapsules of the Isoprothiolane obtained is added in the aqueous suspension agent of dithianon, stirs and obtain 2% Isoprothiolane+50% dithianon microcapsule suspension-suspendinagent agent.
embodiment 1050% Isoprothiolane+1% dithianon suspension seed-coating agent
Above-mentioned each component is mixed in proportion, and through sand milling, is prepared into suspension seed-coating agent.
embodiment 11 active ingredient compositions
Isoprothiolane 20%
Dithianon 80%
Above-mentioned active component is mixed in proportion.
Above embodiment proportioning is weight per distribution ratio.
(2) biological test
1, rice blast fungus test
For examination disease fungus: Pyricularia oryzae (grey pears spore (Pyriculariagrisea))
Test method: adopt growth rate method to measure medicament to the virulence of disease fungus.Be specially, medicament is made into the mother liquor of 1000mg/L, then get appropriate mix according to table 1 predetermined ratio and use 2% Tween 80 solution 5 concentration gradients, then be added in the PDA medium of 45-50 DEG C, mix and pour in the culture dish of sterilizing, form the medium plane of band poison after cooling, clear water is blank, and each concentration repeats 3 times.Afterwards, by pathogen spore suspension (concentration about 1 × 10
6individual) 5 μ l instill in above-mentioned each medium plane, culture dish are placed in 25 DEG C, cultivate 96 hours in the incubator of humidity 90%.Then, take out culture dish, measure colony diameter, and calculate the Developing restraint rate of each chemicals treatment to germ by following formula, and obtain the EC of each process to pathogen
50.
Then, according to the EC of the abundant method of Sun Yun by each process of mensuration
50be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical toxicity index (TTI), by the co-toxicity coefficient (CTC) of following formulae discovery mixture, the results are shown in following table 1.
=
If co-toxicity coefficient is greater than 120, show there is synergistic effect; Co-toxicity coefficient is less than 80, is indicated as antagonism; Co-toxicity coefficient, between 100-120, is indicated as summation action.
table 1 Isoprothiolane and the composite Toxicity Determination result to Pyricularia oryzae of dithianon
The data of table 1 are not difficult to find out, Isoprothiolane and dithianon composite after, in 100:1 to 1:100 scope, all show synergy.
2, bacterium of downy mildew of cucumber test
For examination disease fungus: bacterium of downy mildew of cucumber (
pseudoperonosporacubensis)
Test method: adopt growth rate method to measure medicament to the virulence of disease fungus.Be specially, medicament is made into the mother liquor of 1000mg/L, then get appropriate mix according to table 2 predetermined ratio and use 2% Tween 80 solution 5 concentration gradients, then be added in the PDA medium of 45-50 DEG C, mix and pour in the culture dish of sterilizing, form the medium plane of band poison after cooling, clear water is blank, and each concentration repeats 3 times.Afterwards, by pathogen spore suspension (concentration about 1 × 10
6individual) 5 μ l instill in above-mentioned each medium plane, culture dish are placed in 25 DEG C, cultivate 96 hours in the incubator of humidity 90%.Then, take out culture dish, measure colony diameter, and calculate the Developing restraint rate of each chemicals treatment to germ by following formula, and obtain the EC of each process to pathogen
50.Then, according to the EC of the abundant method of Sun Yun by each process of mensuration
50be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical toxicity index (TTI), by the co-toxicity coefficient (CTC) of following formulae discovery mixture, the results are shown in following table 2(computational methods the same).
table 2 Isoprothiolane and the composite Toxicity Determination result to Pseudoperonospora cubensis of dithianon
The data of table 1 are not difficult to find out, Isoprothiolane and dithianon composite after, in 100:1 to 1:100 scope, all show synergy.
(3) field control effectiveness test
The mensuration present composition and single dose are to the field efficacy of cucumber anthracnose.Plot area 50 square metres, repeats for 4 times.Dispenser process adopts random five point samplings to investigate after 7 days, the results are shown in following table 3.
Disease scale standard is as follows:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 15% of whole leaf area;
5 grades: lesion area accounts for 16% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
Preventive effect computational methods are:
Table 3 result show, Isoprothiolane and dithianon composite after, relative to each single dose, the preventive effect to cucumber anthracnose can be significantly improved.
A kind of bactericidal composition of the present invention is described by specific embodiment.But above-mentioned example is only to further explanation of the present invention, is not limitation of the invention, by the scheme simply adjusted by such scheme and then obtain, does not depart from spirit of the present invention, be all deemed to be included within scope of the present invention.
Claims (12)
1. an active ingredient compositions, is characterized in that containing Isoprothiolane and dithianon, and the weight ratio of described Isoprothiolane and dithianon is 100:1 to 1:100.
2. active ingredient compositions according to claim 1, is characterized in that, the weight ratio of described Isoprothiolane and dithianon is 50:1 to 1:50.
3. active ingredient compositions according to claim 1, is characterized in that, the weight ratio of described Isoprothiolane and dithianon is 20:1 to 1:20.
4. active ingredient compositions according to claim 1, is characterized in that, the weight ratio of described Isoprothiolane and dithianon is 10:1 to 1:10.
5. active ingredient compositions according to claim 1, is characterized in that, the weight ratio of described Isoprothiolane and dithianon is 5:1 to 1:5.
6. a bactericidal composition, is characterized in that, described bactericidal composition comprises active ingredient compositions according to claim 1, and agriculturally acceptable auxiliary agent and/or carrier.
7. a kind of bactericidal composition according to claim 6, is characterized in that, the weight content of described active ingredient compositions in described bactericidal composition is 1wt.% to 80wt.%.
8. a kind of bactericidal composition according to claim 6, is characterized in that, the weight content of described active ingredient compositions in described bactericidal composition is 5wt.% to 60wt.%.
9. a kind of bactericidal composition according to claim 6, is characterized in that, the weight content of described active ingredient compositions in a described bactericidal composition is 10wt.% to 50wt.%.
10. a kind of bactericidal composition according to claim 6, it is characterized in that, described bactericidal composition is prepared into agriculturally acceptable suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wetting powder, suspension seed-coating agent, granule, microcapsule suspending agent.
The active ingredient compositions of 11. claims 1 or the bactericidal composition of claim 6 are for preventing or control the purposes of agricultural disease.
12. 1 kinds of preventions or control the methods of agricultural disease, act on the propagating materials of target useful plant, pathogenic bacteria or its environment, target useful plant by active ingredient compositions according to claim 1 or bactericidal composition according to claim 6.
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| CN109258637A (en) * | 2018-10-17 | 2019-01-25 | 四川省兰月科技有限公司 | Sterilize the composition pesticide of control shoot |
| CN109561675A (en) * | 2016-07-11 | 2019-04-02 | 科思创有限公司 | With the method for Aquo-composition processing seed and the thus seed that handles |
| CN109661175A (en) * | 2016-07-11 | 2019-04-19 | 科思创有限公司 | For handling the Aquo-composition of seed, with the seed of its processing and the method for handling seed |
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| CN1668193A (en) * | 2002-07-18 | 2005-09-14 | 巴斯福股份公司 | Fungicidal mixtures |
| CN1668198A (en) * | 2002-07-18 | 2005-09-14 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101795566A (en) * | 2007-09-07 | 2010-08-04 | 巴斯夫欧洲公司 | Co-crystals of pyrimethanil and dithianon |
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2014
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| CN1668193A (en) * | 2002-07-18 | 2005-09-14 | 巴斯福股份公司 | Fungicidal mixtures |
| CN1668198A (en) * | 2002-07-18 | 2005-09-14 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101795566A (en) * | 2007-09-07 | 2010-08-04 | 巴斯夫欧洲公司 | Co-crystals of pyrimethanil and dithianon |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109561675A (en) * | 2016-07-11 | 2019-04-02 | 科思创有限公司 | With the method for Aquo-composition processing seed and the thus seed that handles |
| CN109661175A (en) * | 2016-07-11 | 2019-04-19 | 科思创有限公司 | For handling the Aquo-composition of seed, with the seed of its processing and the method for handling seed |
| CN109258637A (en) * | 2018-10-17 | 2019-01-25 | 四川省兰月科技有限公司 | Sterilize the composition pesticide of control shoot |
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