CN105536207B - Pre-adaptive training method based on high-low oxygen combination - Google Patents

Abstract

The invention discloses a pre-adaptation training method based on the combination of high and low oxygen, which is characterized in that the training method is based on the output of the pre-adaptation training system and the gas with different oxygen concentrations is inhaled by the user at different durations and frequencies to stimulate A protective substance in the user's body. The method of the invention provides a safe and effective training means for the trainees. As a means different from traditional medicines, the ability of the body to withstand hypoxia or hypoxia can be improved through alternating high and low oxygen pre-adaptation training. The tolerance of cardiomyocytes to ischemia and hypoxia is improved; the endogenous protective substances produced by training can produce neuroprotection and prevent the occurrence of severe ischemic stroke; in addition, the endogenous protective substances can also protect the kidneys , intestinal and lungs and other vital organs have a protective effect.

Description

A pre-adaptation training method based on the combination of high and low oxygen

technical field

The present invention relates to a pre-adaptation training method based on the combination of high and low oxygen, in particular to a training method based on the continuous monitoring of important vital signs of the human body and performing high-intensity and intelligent control of the combined stimulation of hypoxia and hyperxia on the human body .

Background technique

Hypoxia and ischemia will lead to various reactions in the body, such as the damage response of metabolic, functional and morphological disorders caused by tissue hypoxia and the compensatory response of the body to tolerance to hypoxia.

Injury reaction refers to the injury reaction of the body due to insufficient compensation caused by severe or rapid hypoxia, such as pulmonary edema and cerebral edema.

Compensatory response refers to the protective compensatory response of the body caused by mild or slow hypoxia caused by life on the plateau, polar expeditions, human diseases and human aging; long-term hypoxic environment will lead to excessive compensatory response of the body, while Excessive compensatory responses will induce changes in the function and structure of multiple systems in the body, causing various diseases, such as high-altitude heart disease.

Hypoxia is also a factor for the decline of plateau exercise ability, but due to the human body's adaptability to the environment, people who have lived in high-altitude areas for a long time have more obvious anti-hypoxic ability than those who live in low-altitude areas, which shows that the human body's physiological compensation Ability can be improved through appropriate scientific training.

CN 202430001 U discloses a hypoxic generator device system, which is mainly used for athletes to simulate plateau hypoxic environment tolerance training. The design concept of the device is to only provide training environments with different hypoxic concentrations to improve the hypoxic tolerance of trainers Ability, thereby improving the sports performance of the trainers and the adaptability to the polar environment.

In view of the fact that the above training device and method are only used for the training of physiological compensatory ability, and there is no related training method for the improvement of the body's own adaptability under the condition of hypoxia and ischemia, the present invention is proposed.

Contents of the invention

The main purpose of the present invention is to propose a pre-adaptation training method based on the combination of high and low oxygen. This training method uses the environment of simulating the alternate stimulation of high oxygen and low oxygen at different concentrations, and monitors and monitors physiological parameters while training. Feedback ensures the safety of personnel.

After long-term clinical research, it has been found that repeated, multiple, and sufficiently strong hypoxic stimulation to organisms can not only improve the trainee's hypoxic tolerance, but also induce the body to produce endogenous protective substances (such as hypoxia) inducer, adenosine, bradykinin, nitric oxide and vascular growth factor, etc.), this endogenous protective substance can reduce the damage to the body caused by long-term hypoxia and severe hypoxia; Alternate oxygen and hypoxic stimulation training can improve the body's tolerance to acute ischemia/hypoxia, thereby producing a protective effect on important organs such as the heart, brain, and kidney.

The purpose of the present invention can be achieved in the following ways:

A pre-adaptation training method based on the combination of high and low oxygen. This training method is based on the output of the pre-adaptation training system. Gases with different oxygen concentrations are inhaled by users at different durations and frequencies to improve the body's resistance to acute ischemia/hypoxia. tolerance.

The pre-adaptation training mentioned in the present invention refers to training in advance to stimulate endogenous protective substances, enhance the tolerance to hypoxia, and prevent the loss of major organs of the human body caused by hypoxia that may occur subsequently.

Endogenous protective substances stimulated by training currently mainly include: nitric oxide, bradykinin, endogenous opioids, hypoxia-inducible factor, capsaicin, adenosine, endocannabinoids, and erythrocyte-stimulating Epogen (EPO), etc. The above-mentioned pre-adaptation training method includes the following steps:

Store the training program in the pre-adaptation training system;

Input user information into the pre-adaptation training system;

Select the training program according to the input user information; start the high and low oxygen alternate breathing training and monitor the user's real-time physiological parameter values;

If abnormality is detected in the real-time physiological parameters of the user during the training process, the training will be terminated immediately, and if the real-time physiological parameters of the monitored user are normal, the training will continue;

After the training, detect the content of the target substance in the blood and compare it with the detected value before the training;

When the content of any target substance in the blood reaches the predetermined standard or the cumulative number of training days reaches 180 days, the training ends.

In the above pre-adaptation training method, the training program includes the concentration of oxygen in the gas inhaled by the user, the duration of inhaling the gas, and the alternating frequency of inhaling gases with different oxygen concentrations

In the above-mentioned pre-adaptation training method, the selection of training programs includes determining how many sets of training programs to execute, and the execution mode and times of each training program.

In the above pre-adaptation training method, the high and low oxygen alternate breathing training means that the training system alternately outputs gas with an oxygen concentration of 9-19%, 19-23% or 23-93% for the user to inhale.

In the above pre-adaptation training method, the concentration range of oxygen in the gas inhaled by the user is 9-19%, 19-23% or 23-93%; the duration of the gas inhalation is 3-10min, and the alternating frequency is 1 -5 times.

In the above pre-adaptation training method, the real-time physiological parameters include electrocardiogram, blood pressure, cerebral oxygen saturation, blood oxygen saturation and respiratory rate.

In the above pre-adaptation training method, the user information includes the user's basic information and the user's physiological parameter values before training, the user's basic information includes at least the user's height and weight information; the physiological parameters include ECG, blood pressure, brain oxygen Saturation, blood oxygen saturation and respiratory rate.

In the above-mentioned pre-adaptation training method, the target substances in the blood include nitric oxide, bradykinin, endogenous opioids, hypoxia-inducible factor, capsaicin, adenosine, endogenous cannabinoids and erythrocyte-stimulating Epogen (EPO); when the content of any target substance in the blood reaches the predetermined standard or the cumulative number of training days reaches 180 days, the training ends, which means that when the content of any target substance increases by more than 10% or there is no target substance The content has increased by more than 10%, but it has been trained for 180 days. If any situation occurs, the training will end.

In the above-mentioned pre-adaptation training method, the pre-adaptation training system includes:

The central processing unit, based on the pre-stored training program, sends control instructions to the high and low oxygen generating device, and establishes data communication with the remote network data platform and the physiological parameter monitoring unit;

The high and low oxygen generating device receives the control instructions from the central processing unit and alternately outputs high concentration oxygen or low concentration oxygen;

The physiological parameter monitoring unit is used to collect the physiological parameters of the user in the current state in real time;

The remote network data platform, based on the preset standard range of physiological parameters, compares and analyzes the collected physiological parameters of the user in the current state;

Wherein, the central processing unit includes:

The storage module is used to store standard training programs or custom training programs;

GSM communication module, used to establish data communication with the remote network data platform;

The first Bluetooth communication module is used for the physiological parameter monitoring unit to establish data communication and receive the user's physiological parameters in the current state of the user;

The command sending module sends control commands to the high and low oxygen generating device based on the training program or the comparison and analysis results of the remote network data platform;

Human-machine interface for man-machine interaction; and

An alarm module that provides alarm prompts based on the comparison results of physiological parameters on the remote network data platform;

Wherein, the physiological parameters include: ECG data, blood pressure data, cerebral oxygen saturation data, blood oxygen saturation data and respiratory state data;

Wherein, the remote network data platform includes:

The basic information entry module saves the basic user information entered by the central processing unit;

The ECG data management unit is used to obtain and save the ECG data during the user training process;

The blood oxygen saturation data management unit is used to obtain and save the blood oxygen saturation value of the user at a certain training moment;

The brain oxygen saturation data management unit is used to obtain and save the brain oxygen saturation data of the user at a certain training moment;

A blood pressure data management unit for acquiring and saving the user's blood pressure data; and

Respiratory rate management unit for acquiring and saving the respiration rate of the user during training; and

The alarm and alert data setting module is used to set the normal range threshold of physiological parameters;

The comparison module compares the real-time physiological parameters transmitted by the central processing unit based on the threshold value of the normal range of the physiological parameters, and obtains a comparison result;

Wherein, the high and low oxygen generating device includes:

air inlet;

Oxygen production module, is used for producing oxygen; What produce in the present invention is the oxygen that oxygen content is 93%;

Nitrogen-making module is used to produce nitrogen; what produced in the present invention is the nitrogen that nitrogen content is 97%

The first mass flow controller adjusts the flow of oxygen generated by the oxygen generating module based on a preset flow value or an external control command;

The second mass flow controller adjusts the flow of nitrogen generated by the nitrogen generating module based on a preset flow value or an external control command;

Gas mixing unit; mix the oxygen generated by the oxygen generating module and the nitrogen generated by the nitrogen generating module into a mixed gas with different high and low oxygen concentrations that meets the training requirements; and

air outlet;

Further, the high and low oxygen generating device also includes a gas generator controller for controlling the gas flow;

The gas generator controller includes

A data communication module for establishing data communication with the central processing unit;

A comparative analysis module for comparing the concentration and flow of oxygen output by the current oxygen generation module or the pressure, flow, and oxygen concentration of the mixed gas output by the current high and low oxygen generating device with the preset standard value; and

Based on the comparison result, a control signal sending module that sends a control signal.

The beneficial effects of the present invention are as follows:

The high and low oxygen combined pre-adaptation training method provided by the present invention provides a safe and effective training method for trainees. As a means different from traditional medicines, the high and low oxygen combined pre-adaptation training can improve the body's endurance. Hypoxic or hypoxic capacity. The tolerance of cardiomyocytes to ischemia and hypoxia is improved; the endogenous protective substances produced by training can produce neuroprotection and prevent the occurrence of severe ischemic stroke; in addition, the endogenous protective substances can also protect the kidneys , intestines and lungs and other vital organs have a protective effect.

Description of drawings

The specific implementation manners of the present invention will be further described in detail below in conjunction with the accompanying drawings.

Fig. 1 is a schematic diagram of the high and low oxygen alternating pre-adaptation training system;

Fig. 2 is a schematic diagram of the pre-adaptation training process;

Fig. 3 is a schematic diagram of a high and low oxygen generating device;

Fig. 4a is the structural representation of oxygen production module;

Fig. 4b is a schematic structural diagram of an oxygen generating module;

Fig. 4c is a schematic structural diagram of an oxygen generating module;

Fig. 5 is a schematic diagram of a remote network data platform.

Following are the reference signs of the present invention:

Central processing unit 1; high and low oxygen generation device 2; physiological parameter monitoring unit 3; remote network data platform 4; respiratory mask 5; man-machine interface 6; GSM communication module 7; first bluetooth communication module 8; respiratory state detection module 9; Blood oxygen saturation detection module 10; Brain oxygen saturation detection module 11; Blood pressure detection module 12; ECG detection module 13; First air filter 14; Oxygen making module 15; Mass flow controller 17; first check valve 18; first oxygen concentration sensor 19; first flow sensor 20; second air filter 21; nitrogen making module 22; second fine air filter 23; second mass flow control Device 24; second one-way valve 25; gas generator controller 26; primary gas mixer 27; secondary gas mixer 28; mixed gas pressure regulating valve 29; pressure sensor 30; second oxygen concentration sensor 31; Two flow sensors 32; two-position three-way valve 33; flow regulator 34; heating humidifier 35; air compressor 36; first adsorber 37; three-way 38; second adsorber 39; rotary separation valve 40; Synchronous motor 41; Controller 42; The first rotary valve 43; The second rotary valve 44; The third rotary valve 45; The fourth rotary valve 46; Air outlet 47; Air inlet 48; Basic information input module 50; Determination module 51; ECG data management unit 52; blood oxygen saturation data management unit 53; brain oxygen saturation data management unit 54; blood pressure data management unit 55; respiratory rate management unit 56; storage module 57; comparison module 58; A pressure sensor 59 ; a second Bluetooth communication module 60 ; a user 61 ; an alarm module 62 ; and an instruction sending module 63 .

detailed description

In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments and accompanying drawings. Similar parts in the figures are denoted by the same reference numerals. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

The training in the present invention refers to the high and low oxygen alternating combined stimulation process for improving the ability of qualified trainees to resist hypoxia.

Hypoxia is: refers to the range of oxygen concentration between 9% and 19%.

Hyperoxia: refers to the range of oxygen concentration between 23% and 93%.

The user in the embodiment of the present invention is a trainee receiving training.

Example 1

A high and low oxygen generating device.

As shown in Fig. 3, a kind of high and low oxygen generation device, this device comprises air inlet 48, oxygen making module 15, nitrogen making module 22, first mass flow controller 17, second mass flow controller 24, gas mixing unit and outlet Air port 47; the air enters the oxygen generator module 15 and the nitrogen generator module 22 respectively after passing through the air inlet; a part of the air is processed by the oxygen generator module 15 to output oxygen with an oxygen concentration of 93%, and the other part of the air is output after being processed by the nitrogen generator module 22 The nitrogen concentration is 97% nitrogen; the 93% oxygen that is flow controlled by the first mass flow controller 17 is mixed with the 97% nitrogen that is flow controlled by the second mass flow controller 24 in the gas mixing unit to form a mixture containing The mixed gas with different concentrations of oxygen is output, and the mixed gas is finally output to external equipment or users through the gas outlet 47 .

In order to make the pressure of the output mixed gas meet the requirements of training, it is necessary to adjust and control the pressure and flow of the mixed gas containing different concentrations of oxygen output by the gas mixing unit. A mixed gas pressure regulating valve 29 and a flow regulating valve 34 are provided to ensure that the pressure and flow of the mixed gas output by the high and low oxygen generating device meet the training requirements. For example, the flow rate of the output gas is adjusted from 1L/min to 5L/min for the user to breathe. In this program, in order to prevent emergencies such as hypoxia caused by the user’s inability to adapt to alternate oxygen inhalation and hypoxia caused by abnormal oxygen concentration supply during the training process, there is further set between the mixed gas pressure regulating valve 29 and the flow regulating valve 34. The two-position three-way valve 33, the outlet of the two-position three-way valve 33 is connected to the air outlet 47 through the flow regulator 34, the first air inlet of the two-position three-way valve is connected to the mixed gas pressure regulating valve 29, the two-position three-way The second air inlet of the valve 33 is directly connected with the oxygen generator module 15; under normal circumstances, the ventilation position of the two-position three-way valve 33 is adjusted to the first air inlet, and the mixed gas passes through the flow regulator 34 and the air outlet 47 connected, under abnormal circumstances, the ventilation position of the two-position three-way valve 33 is adjusted to the second air inlet, and 93% of the oxygen output by the oxygen-making module is directly connected with the air outlet 47 through the flow regulator 34 to provide the user with 93% oxygen.

In the normal training process, in order to further ensure that the device outputs a stable quality mixed gas, in this solution, a pressure sensor 30 and a second oxygen concentration sensor 31 are sequentially arranged between the mixed gas pressure regulating valve 29 and the two-position three-way valve 33 and the second flow sensor 32; the pressure, oxygen concentration and flow of the mixed gas output by the mixed gas pressure regulating valve 29 can be collected in real time through the above sensor, and the oxygen generating device can use the collected current The pressure, oxygen concentration and flow of the mixed gas are compared with the preset training indicators, and the output mixed gas is adjusted appropriately according to the comparison results. In order to ensure that the difference between the oxygen concentration in the final actual output mixed gas and the oxygen concentration set for training is kept within the range of plus or minus 5%.

In order to improve the breathing comfort of the user, a heated humidifier 35 is further provided between the two-position three-way valve 33 and the air outlet 47 in this solution, and the heated humidifier 35 is used to heat and humidify the mixed gas, so that The final output mixture is more suitable for breathing training.

In order to improve the accuracy and controllability of the device output, the device further includes a gas generator control unit for automatically controlling the gas output of the device; the gas generator controller control unit includes a data communication module for receiving external data , a comparative analysis module for comparing the pressure, flow rate, and oxygen concentration value of the current output gas with the standard value, and a control signal sending module for sending a control signal based on the comparison result; the data communication module receives the required output gas sent by an external device Standard index values such as pressure, flow rate, oxygen concentration, etc., and current values such as pressure, flow rate, oxygen concentration, etc. Perform comparative analysis to obtain the difference between the current value and the index value, and the control signal sending module generates the first control signal, the second control signal and the third control signal according to the difference, respectively controlling the first mass flow controller 17, the second Two mass flow controllers 24 and a mixer pressure regulating valve 29 keep the difference between the oxygen concentration in the mixed gas output by the oxygen generating device and the oxygen concentration required for training within the range of plus or minus 5%. In this solution, the oxygen generator control unit is a gas generator controller 26 .

When the oxygen concentration and flow output of the oxygen generating device are abnormal, assist the gas generator controller 26 to detect whether the oxygen generation module 15 is abnormal, and control the start of the first mass flow controller 17 and the second mass flow controller 24 For this purpose, an auxiliary detection unit of the oxygen generation module is provided between the oxygen generation module 15 and the gas generator controller 26 , and the auxiliary detection unit of the oxygen generation module includes a first oxygen concentration sensor 19 and a first flow sensor 20 . The gas generator controller 26 sets the first mass flow rate according to the oxygen concentration and flow rate output by the oxygen generator module 15 measured by the first oxygen concentration sensor 19 and the first flow sensor 20, and the oxygen concentration set value sent from the external device controller 17 and the initial flow value of the second mass flow controller 24, and when the oxygen concentration and flow of the final output gas do not meet the set value, the first oxygen concentration sensor 19 and the first flow sensor 20 can assist the gas The generator controller 26 detects whether the oxygen concentration and flow are abnormal due to the abnormality of the oxygen generating module 15 .

In order to ensure the cleanliness of the air passing into the device, the first air filter 14 and the second air filter 21 are respectively added between the oxygen making module 15 and the nitrogen making module 22 and the air inlet 48, so as to pass into the air. primary filtration. In this solution, in order to make the output gases of the oxygen generator module 15 and the nitrogen generator module 22 more pure, a first fine air filter 16 and a second fine air filter 23 are provided at the output ends of the oxygen generator module 15 and the nitrogen generator module 22 respectively. Through the above-mentioned design, when producing oxygen and nitrogen, the air is initially filtered first, and then the pre-filtered air is passed into the oxygen production module 15 and the nitrogen production module 22, and then the first fine air filter 16 and the second fine air filter are used to The filter 23 fine-filtrates 93% of the oxygen and 97% of the nitrogen produced respectively to obtain higher quality oxygen and nitrogen for preparation of subsequent mixed gases. In this solution, in order to prevent oxygen and nitrogen from generating gas backflow when entering the gas mixing unit and causing danger, between the first mass flow controller 17 and the gas mixing unit and between the second mass flow controller 24 and the gas mixing unit The first one-way valve 18 and the second one-way valve 25 are provided to ensure the one-way check when the gas is mixed and prevent the phenomenon of gas backflow. In order to make the gas mix more evenly and the mixed quality and pressure reach the predetermined value, the gas mixing unit of this device adopts a two-stage gas mixer; 93% of oxygen and 97% of nitrogen pass through the primary gas mixer 27 and the secondary gas The mixer 28 mixes, so that the index of the mixed gas reaches a predetermined value, so as to meet the needs of the user for high-low alternating training.

As shown in Figure 4, the oxygen generation module 15 and the nitrogen generation module 22 in this device adopt the existing skarstrom double molecular sieve tower structure.

The operating principle of the high and low oxygen generating device described in the present invention is as follows:

The air is passed into the device through the air inlet 48, a part of the air is initially filtered by the first air filter 14 and then sent to the oxygen generation module 15, and the other part of the air is sent to the nitrogen generation module 22 after the second air filter 21 is initially filtered. The oxygen production module 15 outputs oxygen with a concentration of 93% and a flow rate of 10L/M; the nitrogen production module 22 outputs nitrogen with a concentration of 97% and a flow rate of 10L/M; Enter the first mass flow controller 17, while the first oxygen concentration sensor 19 and the first flow sensor 20 measure the actual concentration and flow of the oxygen output by the oxygen making module 15 in real time, and the measurement results are sent to the gas generator controller 26; The nitrogen gas output by the nitrogen making module 22 is finely filtered by the second fine air filter 23 and sent to the second mass flow controller 24; the gas generator controller 26 is based on the oxygen concentration measured by the first oxygen concentration sensor 19 and the first flow sensor 20 and flow, and the oxygen concentration setting value sent from the external equipment to set the initial flow value of the first mass flow controller 17 and the second mass flow controller 24, and complete the training program with a specific oxygen concentration mixed Preliminary preparation of gas; the 93% oxygen produced by the oxygen production module is adjusted to a suitable flow rate by the first mass flow controller 17, and then sent to the gas mixing unit through the first one-way valve 18, and the 97% nitrogen produced by the nitrogen production module After utilizing the second mass flow controller 24 to adjust to a suitable flow rate, it is sent to the gas mixing unit through the second one-way valve 25; 93% of the oxygen and 97% of the nitrogen pass through the primary gas mixer 27 and the secondary mixer 28 successively Mix to form a mixed gas with a pressure of 70-100KPa; after the pressure is adjusted by the mixed gas pressure regulating valve 29, the high-pressure mixed gas passes through the two-position three-way valve 33, the flow regulator 34 and the heating humidifier 35 in sequence to form a mixture that meets the training requirements. The mixed gas is output from the gas outlet 47 to external equipment or users. During the mixed gas output process, the pressure sensor 30, the second oxygen concentration sensor 31 and the second flow sensor 32 are used to measure the mixed gas pressure, the oxygen concentration in the mixed gas and the mixed gas flow rate of the mixed gas after pressure regulation, and the The measured value is fed back to the gas generator controller 26, so that the gas generator controller 26 fine-tunes the flow of the first mass flow controller 17 and the second mass flow controller 24, and the oxygen in the output mixed gas is fine-tuned. The difference between the concentration and the oxygen concentration set for training was kept within plus or minus 5%. When the physiological index of the user is abnormal, the central processing unit sends an instruction to stop nitrogen production to the gas generator controller 26 according to the abnormal physiological parameters, and the gas generator controller 26 stops the work of the nitrogen generating module 22 after receiving the instruction. Control the two-position three-way valve 33 to switch from the connection position of the first air inlet to the connection position of the second air inlet to directly provide the user with 93% oxygen to relieve abnormal conditions. In the present invention, the oxygen production module 15 and the nitrogen production module 22 all adopt the existing skarstrom double molecular sieve tower structure, that is, the pressure swing adsorption PSA air separation technology is used to realize oxygen production and nitrogen production. As the raw material gas, the difference in "adsorption" performance of molecular sieves to different gas molecules under pressurized conditions is used to separate the gas mixture; the molecular sieves used in the nitrogen production module are carbon molecular sieves, and the adsorption capacity of oxygen under pressurized conditions is higher than that of nitrogen in the air. , carbon dioxide, moisture and other air components are high, absorb oxygen, carbon dioxide, moisture, etc. in the raw material gas, and produce nitrogen; the molecular sieve used in the oxygen production module is zeolite molecular sieve, which has high adsorption capacity for nitrogen, and absorbs nitrogen, carbon dioxide, moisture, etc. under pressurized conditions , producing oxygen.

Except for the different molecular sieves used, the working principle and structure of the two modules of nitrogen generation and oxygen generation are the same.

The structure and working principle of the oxygen production module are shown in Figure 4a. The skarstrom double molecular sieve tower structure is adopted. The working process is as follows: the air enters the air compressor 36 after being filtered by the first air filter 14, and the compressed air passes through the rotary separation valve 40 Enter the first adsorber 37 or the second adsorber 39 for adsorption separation, and the gas generator controller 26 controls the rotary separation valve 40 to change the adsorption cycle and distribute the flow direction of intake air and exhaust gas to realize oxygen production.

Taking a cycle in the working process of the oxygen generating module 15 as an example, as shown in Figure 4b, the compressed air enters the first adsorber 37, at this time the first rotary valve 43 and the second rotary valve 44 are opened, and the third rotary valve 45, the second rotary valve The four rotary valves 46 are closed, the nitrogen in the air is absorbed into the molecular sieve in the first adsorber 37, the oxygen flows out through the tee 38 at the top of the first adsorber 37, and part of it is used to blow back the second adsorber in the desorption state 39, the other part is output through the fine sieve of the first fine air filter 16; before the molecular sieve in the first adsorber 37 reaches the critical state of adsorption saturation, the controller 42 receives the instruction of the gas generator controller and turns the first rotary valve 43, The second rotary valve 44 is closed, and the third rotary valve 45 and the fourth rotary valve 46 are opened. As shown in FIG. Decompression desorption, desorption gas (nitrogen-enriched) is discharged through the third rotary valve 45. The working process of the second adsorber 39 is exactly the same as that of the first adsorber 37, and the two work alternately to complete the continuous production of oxygen. The working process of the nitrogen generating module and the oxygen generating module are exactly the same, the only difference is that the molecular sieves in the third adsorber and the fourth adsorber in the nitrogen generating module are carbon molecular sieves.

In the present invention, the gas generator controller 26 adopts the STM32F103 type embedded microprocessor, and the corresponding control voltage is sent to the first mass flow controller 17 and the second mass flow controller 24 by the D/A converter in the STM32F103, In order to achieve flow control.

Example 2

A pre-adaptation training system based on the combination of high and low oxygen.

A pre-adaptation training system based on the combination of high and low oxygen, the system includes a central processing unit 1, an oxygen generating device 2, a physiological parameter monitoring unit 3 and a remote network data platform 4.

The remote network data platform 4 includes a basic information input module 50, an alarm warning line data setting module 51, an ECG data management unit 52, a blood oxygen saturation data management unit 53, a cerebral oxygen saturation data management unit 54, and a blood pressure data management unit 55 , a respiratory frequency management unit 56 , and a comparison module 58 .

The basic information entry module 50 saves the user basic information entered by the central processing unit, and the basic information includes name, age, gender, height, weight, blood pressure, heart rate, past medical history, etc. at the beginning of training.

The normal range of physiological parameters is as follows: the normal range of pulse oxygen saturation is greater than or equal to 90%, the normal range of cerebral oxygen saturation is 58-82%, the normal range of heart rate is 60-101 beats/min, and the normal range of blood pressure is 90% of systolic blood pressure. -140mmHg, diastolic blood pressure 60-9-mmHg, respiratory rate normal range is 16-20 breaths/min.

The electrocardiographic data management unit 52 is used to obtain and save the electrocardiographic data in the user's training process, and echo the electrocardiographic waveform according to the electrocardiographic data, and describe the change trend curve of the heart rate according to the time axis; Query the analysis indicators such as ECG data, ECG waveform and heart rate change trend. The ECG data management unit includes an ECG data acquisition module for obtaining the user's current ECG data; an ECG query module for querying analysis indicators such as current ECG data, ECG waveforms, and heart rate trends; The warning line data setting module 51 pre-sets the ECG normal range threshold, and is an analysis module for analyzing and comparing the current ECG data.

The blood oxygen saturation data management unit 53 is used to obtain and save the blood oxygen saturation value of the user at a certain training moment, and query the data according to the needs of the user. The blood oxygen saturation data management unit 53 includes a blood oxygen saturation data acquisition module for obtaining the user's current blood oxygen saturation data; a blood oxygen saturation data acquisition module for querying the blood oxygen saturation value at a certain training treatment moment A degree query module; an analysis module for analyzing and comparing the current blood oxygen saturation data based on the blood oxygen saturation normal range threshold preset by the alarm warning line data setting module 51.

The brain oxygen saturation data management unit 54 is used to obtain and save the brain oxygen saturation data of the user at a certain training moment, and describe the change trend of the brain oxygen saturation over time according to the brain oxygen saturation data; The current brain oxygen saturation data needs to be queried. The cerebral oxygen saturation data management unit includes a cerebral oxygen saturation data acquisition module for obtaining the current cerebral oxygen saturation data of the user; an ECG query module for querying the current cerebral oxygen saturation data; The setting module 51 pre-sets the threshold value of the normal range of the cerebral oxygen saturation, and is an analysis module for analyzing and comparing the current cerebral oxygen saturation data.

The blood pressure data management unit 55 is used to obtain and save the user's blood pressure data, and describe it according to the change trend of the blood pressure data; the user can query the current blood pressure data as needed. The blood pressure data management unit includes a blood pressure data acquisition module for obtaining the current blood pressure data of trainees; a blood pressure data query module for querying the current blood pressure data; Threshold, an analysis module that analyzes and compares current blood pressure data.

The respiratory frequency management unit 56 is used to obtain and save the respiratory frequency during the training process of the user, and perform trend analysis according to the respiratory frequency, and display the respiratory waveform; the user can query the current respiratory frequency as required. The respiratory frequency management unit 56 includes a respiratory frequency acquisition module for obtaining the current respiratory frequency of the user; a respiratory frequency query module for querying the current respiratory frequency; the respiratory frequency preset by the alarm warning data setting module 51 is normal Range threshold, an analysis module for analyzing and comparing the current respiratory rate.

The alarm warning line data setting module 51 is used to set the normal range threshold of physiological parameters.

Comparison module 58, based on the preset normal range threshold of ECG, blood oxygen saturation, normal range threshold of cerebral oxygen saturation, normal blood pressure threshold and normal respiratory rate threshold set by alarm setting module 51, for the current The detected ECG data, blood oxygen saturation data, cerebral oxygen saturation data, blood pressure data and respiration data are analyzed and compared, and if they exceed the normal range, an alarm will be sent to the central processing unit 1 through images or sounds.

The central processing unit 1 in this system includes a human-computer interaction interface 6 for man-machine interaction, a GSM communication module 7 for establishing data communication with a remote network data platform, and a first bluetooth for receiving user physiological parameter data. The communication module 8, the storage module 57 for storing the set training program, and the alarm module 62 for alarming based on the physiological parameter comparison results of the remote network data platform. The central processing unit 1 establishes data communication with the remote network data platform 4 through the GSM communication module 7, and performs operations such as reading of pre-stored training programs, setting of personalized programs, and query of physiological parameter data through the human-computer interaction interface 6; The processing unit 1 sends a control command to the gas generator controller 26 in the oxygen generator 2 through the serial port based on the read pre-stored training program or custom program in the storage module 57, and the control command includes oxygen concentration and a certain oxygen concentration. Concentration duration, etc., the oxygen generating device 2 outputs oxygen-containing mixed gas based on the control command; during the user's high and low oxygen alternate training process, the first Bluetooth communication module 8 in the central processing unit 1 will obtain the physiological parameter monitoring unit in real time 3 sends the user's current physiological parameter data, and sends the data to the remote network data platform 4 for analysis and storage. The user can use the human-computer interaction interface 6 in the central processing unit 1 to query the user's current physiological parameter data acquired by the central processing unit 1 or the analysis results of the remote network data platform to know the current physiological condition of the user. The gas generator controller 26 can also obtain the state of the user's breathing gas through the first bluetooth communication module 8 in the central processing unit 1, such as when the user uses the breathing mask to supply oxygen, the user's breathing rate, the breathing mask state (air leakage or falling off) ), to maintain and adjust the training system in time.

The structure, composition and working principle of the oxygen generator 2 are as described in Example 1.

The physiological parameter monitoring unit in this system is used to monitor the current physiological parameters of the user. The physiological parameter monitoring unit includes a respiratory state detection module 9, a blood oxygen saturation detection module 10, a cerebral oxygen saturation detection module 11, a blood pressure detection module 12, an electrocardiogram detection module 13 and a second Bluetooth communication module 60; One or more monitoring instruments capable of monitoring the above physiological parameters. All the above abnormal alarm prompt information of physiological parameters will also be sent to the user's contact mobile phone by the remote network data platform.

The working principle of a pre-adaptation training system based on the combination of high and low oxygen is as follows:

Central processing unit 1 establishes data communication with remote network data platform 4 through GSM communication module 7, and during training, central processing unit 1 sends physiological parameters to remote network data platform 4 through GSM communication module 7; The obtained training program sends a control instruction to the gas generator controller 26 in the oxygen generator 2 through the serial port, the control instruction includes the oxygen concentration and the duration of the oxygen concentration, and the oxygen generator 2 alternately outputs the high and low oxygen content based on the control instruction Different gases; and use the breathing mask to provide the user with alternating high and low oxygen gas. During the high-low oxygen alternating training process, the user uses the blood oxygen saturation, brain oxygen saturation, blood pressure, ECG and respiration detection modules in the physiological parameter monitoring unit 3 to collect the user's current physiological parameter data in real time, and transmits the data through Bluetooth The communication module 60 sends the physiological parameter data to the first bluetooth communication module 8 of the central processing unit 1; the first bluetooth communication module 8 in the central processing unit 1 can obtain the current physiological parameter data of the user in real time, and send the data to The remote network data platform 4 performs analysis, and the data analyzed by the remote network data platform 4 can analyze the user's current physiological parameter data and the remote network data platform through the human-computer interaction interface 6 in the central processing unit 1 according to the needs of the user The results are queried to know the current physiological state, and the oxygen generating device 2 is adjusted according to the current physiological state to realize the cyclic operation of the training system. The first Bluetooth communication module 8 in the central processing unit 1 can also know the state when the user inhales oxygen that is arranged on the breathing pressure sensor 59 on the breathing mask through the gas generator controller 26, for example, when the user uses the breathing mask to inhale oxygen, The user's breathing rate, the status of the breathing mask (air leakage or falling off), and timely maintenance and adjustment of the training system. During the alternating high and low oxygen training process, if abnormalities in physiological parameters are found, based on the comparison results of the remote network data platform 4, the alarm module in the central processing unit 1 sends out an alarm, and through the human-computer interaction interface 6 in the central processing unit 1 The alarm information is displayed, and at the same time, the central processing unit sends an emergency control command to the oxygen generator, and the oxygen generator stops nitrogen production according to the emergency control command, and directly provides the produced gas containing high-concentration oxygen to the user, thereby realizing the emergency capability of the system .

Example 3

A pre-adaptation training method based on the combination of high and low oxygen

This training method is based on the gas with different oxygen concentration output by the pre-adaptation training system, which is inhaled by the user at different durations and frequencies to improve the body's tolerance to acute ischemia/hypoxia.

The pre-adaptation training method based on high and low oxygen combination of the present invention comprises the following steps:

Store the training program in the pre-adaptation training system;

Input user information into the pre-adaptation training system;

Select the training program according to the input user information; start the high and low oxygen alternate breathing training and monitor the user's real-time physiological parameter values;

If abnormality is detected in the real-time physiological parameters of the user during the training process, the training will be terminated immediately, and if the real-time physiological parameters of the monitored user are normal, the training will continue;

After the training, detect the content of the target substance in the blood and compare it with the detected value before the training;

When the content of any target substance in the blood reaches the predetermined standard or the cumulative number of training days reaches 180 days, the training ends.

Specifically include the following steps:

Before applying the pre-adaptation training system based on the combination of high and low oxygen to start training, several sets of training programs need to be pre-stored in the training system. The training programs pre-stored in the central processing unit are shown in Table 1:

Scheme number oxygen concentration duration oxygen concentration duration oxygen concentration duration oxygen concentration duration 1 19% 5min twenty one% 5min 19% 10min twenty one% 5min 2 17% 5min twenty one% 5min 17% 10min twenty one% 5min 3 15% 5min twenty one% 5min 15% 10min twenty one% 5min 4 12% 3min 30% 1min 12% 5min 30% 1min 5 12% 5min 40% 1min 12% 10min 40% 1min

Table 1

The first set of training programs, specifically, in the hypoxic range, set the first low-concentration oxygen, such as the oxygen content is 19%, continue to supply oxygen for a period of time, such as 5 minutes of oxygen supply, after the low-concentration oxygen supply stops , restore normal concentration of oxygen supply, such as oxygen content is 21%, continue to supply oxygen for the same time, such as 5 minutes, and then provide the first low concentration of oxygen, such as oxygen content is 19%, continue to supply oxygen for the same time, For example, after 10 minutes, after the low-concentration oxygen supply stops, restore the normal concentration of oxygen supply. If the oxygen content is 21%, continue the oxygen supply for the same time, such as 5 minutes; this is the first training program; the first training program During the process, the physiological parameter monitoring system monitors the trainee's ECG, blood pressure, brain oxygen and blood oxygen data in real time, and transmits the collected data to the central processing unit through the Bluetooth communication module, and the central processing unit then transmits the received physiological parameters The data is transmitted to the remote network data platform through the GSM communication module. The remote network data platform compares the received physiological parameters with the stored normal physiological parameter value ranges. If the comparison result is normal, the training will continue;

The content of the second set of training programs is as follows: within the hypoxic range, set the second lowest concentration of oxygen, such as oxygen content of 17%, continue to supply oxygen for a period of time, such as 5 minutes of oxygen supply, after the oxygen supply of low concentration oxygen stops, Restore normal concentration of oxygen, such as oxygen content of 21%, continue to supply oxygen for the same time, such as 5 minutes, and then provide the second lowest concentration of oxygen, such as oxygen content of 17%, continue to supply oxygen for the same time, such as After 10 minutes, after the low-concentration oxygen supply stops, restore the normal concentration of oxygen supply, such as oxygen content of 21%, and continue the oxygen supply for the same time, such as 5 minutes; this is the second training program; During the process, the physiological parameter monitor monitors the trainee's ECG, blood pressure, brain oxygen and blood oxygen data in real time, and transmits the collected data to the central processing unit through the Bluetooth communication module, and the central processing unit then transmits the received physiological parameter data The data is transmitted to the remote network data platform through the GSM communication module, and the received physiological parameters are compared with the stored normal physiological parameter value ranges. If the comparison result is normal, the training will continue;

The third set of training plan, the content of the plan is as follows: within the hypoxic range, set the third lowest concentration of oxygen, such as the oxygen content is 15%, continue to supply oxygen for a period of time, such as 5 minutes of oxygen supply, stop the oxygen supply of low concentration oxygen After that, restore normal concentration of oxygen supply, such as oxygen content is 21%, continue to supply oxygen for the same time, such as 5 minutes, and then provide the third low concentration of oxygen, such as oxygen content is 15%, continue to supply oxygen for the same time , such as 10 minutes, after the low-concentration oxygen supply stops, restore the normal concentration of oxygen supply, such as 21% oxygen, continue the oxygen supply for the same time, such as 5 minutes; this is the third set of training programs; in the third set of training During the process of the program, the physiological parameter monitor monitors the trainee's ECG, blood pressure, brain oxygen and blood oxygen data in real time, and transmits the collected data to the central processing unit through the Bluetooth communication module, and the central processing unit then transmits the received physiological parameters The parameter data is transmitted to the remote network data platform through the GSM communication module, and the received physiological parameters are compared with the stored normal physiological parameter value ranges. If the comparison result is normal, the training will continue;

The fourth set of training plan, the content of the plan is as follows: within the hypoxic range, set the fourth lowest concentration of oxygen, such as oxygen content is 12%, continue to supply oxygen for a period of time, such as oxygen supply for 3 minutes, stop the low concentration oxygen supply Finally, supply high-concentration oxygen, such as the oxygen content is 30%, continue to supply oxygen for a period of time, such as 1 minute, and then provide the fourth low-concentration oxygen, such as oxygen content is 12%, continue to supply oxygen for a period of time, such as 5 Minutes, after the low-concentration oxygen supply stops, supply high-concentration oxygen, such as 30% oxygen content, and continue to supply oxygen for a period of time, such as 1 minute; this is the fourth training program; during the fourth training program , The physiological parameter monitor monitors the trainee's ECG, blood pressure, brain oxygen and blood oxygen data in real time, and transmits the collected data to the central processing unit through the Bluetooth communication module, and the central processing unit then transmits the received physiological parameter data through GSM communication The module transmits data to the remote network data platform, and the central processing unit 1 compares the received physiological parameters with the stored normal physiological parameter value ranges, and if the comparison result is normal, the training continues;

The fifth set of training plan, the specific content of the plan is as follows: within the hypoxic range, set the fifth lowest concentration of oxygen, such as the oxygen content is 12%, continue to supply oxygen for a period of time, such as 5 minutes of oxygen supply, stop the oxygen supply of low concentration oxygen Finally, supply high-concentration oxygen, such as oxygen content is 40%, continue to supply oxygen for a period of time, such as 1 minute, and then provide the fifth low-concentration oxygen, such as oxygen content is 12%, continue to supply oxygen for a period of time, such as 10 Minutes, after the low-concentration oxygen supply stops, supply high-concentration oxygen, such as 40% oxygen content, and continue to supply oxygen for a period of time, such as 1 minute; this is the fifth training program; during the fifth training program , The physiological parameter monitor monitors the trainee's ECG, blood pressure, brain oxygen and blood oxygen data in real time, and transmits the collected data to the central processing unit through the Bluetooth communication module, and the central processing unit then transmits the received physiological parameter data through GSM communication The module is transmitted to the remote network data platform, and the central processing unit 1 compares the received physiological parameters with the stored normal physiological parameter value ranges, and if the comparison result is normal, the training continues;

First, the basic user information is collected, and the collected basic user information is input into the training system through the human-computer interaction interface of the central processing unit for storage. Specifically, the central processing unit transmits the collected data to the remote network data platform through the GSM communication module. The information input module is stored; the user's basic information includes the user's name, age, gender, height and weight, and the body mass index can be obtained through the user's basic information, body mass index = weight (kg)/height square ( ^m2 ), body mass index The normal range is 18.5--24.99. After the user's basic information is entered, the user's physiological parameters are measured. The physiological parameters include ECG, blood pressure, respiratory rate, cerebral oxygen saturation and blood oxygen saturation data. The range is ECG 60-101 times/min, blood pressure systolic pressure 90-140mmHg, diastolic blood pressure 60-90mmHg, cerebral oxygen saturation 58%-82%, blood oxygen saturation greater than or equal to 90%, respiratory rate 16-20 times/ min.

For users who participate in training, before the training begins, the blood of nitric oxide, bradykinin, endogenous opioids, hypoxia-inducible factor, capsaicin, adenosine, endogenous cannabis To detect the content of hormones (such as N-arachidonic acid aminoethanol (anandamine) and 2-arachidonic acid glycerol (2-AG)), erythropoietin (EPO) and so on, so as to judge the effect of training at the end of training .

Users whose body mass index or physiological parameters are not in the normal range can also carry out training, just pay attention to the arrangement of the training program and observe the changes of physiological parameters during training to ensure the safety of users. The principle of training is step-by-step. A set of programs is executed every day, and the training is performed 3 times. During the 3 training sessions, the training is continuous. Each program is trained continuously for 10 days. After training, if the user's various physiological parameters are within the normal range, then Carry out the training of the next set of programs. The next set of programs will be trained continuously for 10 days, and the training program will be trained 3 times a day. During the training process, pay attention to observing the user's physiological parameter values. Train for 10 days until the scheduled training is completed;

The implementation of the specific training program is classified as follows:

For users with normal body mass index and pre-training physiological parameters, you can directly start training from the third set of programs, and then proceed to the training of the fourth and fifth sets of programs,

For users whose brain oxygen saturation is greater than 75%, you can directly start training from the fourth set of programs, and then execute the fifth set of training programs;

For hypertensive users, before the training starts, use drugs to control their blood pressure within the normal range, and then start from the second program, and then train the second, third, fourth, and fifth programs in sequence;

Except for the users who have the following conditions and the aforementioned users who do not need to start training from the first set of plans, the rest of the users will start from the first set of plans and execute the second set, the third set, the fourth set, and the fifth set of plans in sequence;

When the user has the following conditions, the user cannot participate in the training:

1. Cerebral oxygen saturation is less than 58%;

2. When the body mass index is greater than 28 or less than 18.5;

2. The blood pressure of hypertensive patients is still beyond the normal range after drug control;

3. When the blood oxygen saturation is less than 90%;

4. Patients with arrhythmia and heart disease;

5. Pregnant women, those who are preparing for pregnancy or breastfeeding, those who are unconscious, those who cannot take care of themselves are prohibited from training, mental illness, severe liver and kidney damage, cerebral hemorrhage, cervical spondylosis or dizziness symptoms caused by non-ischemic lesions, and tumor expectations Users who have survived for less than 2 years, are taking drugs in the research period or participating in other research experiments, and users with vascular ischemic diseases of the extremities.

After completing the 5 sets of training programs, carry out the 6th or 7th training program according to the user's various physiological parameters, and conduct blood tests on the users who have completed the 5 sets of training programs to analyze the nitric oxide and slowing down in the blood. Kinins, endogenous opioids, hypoxia-inducible factor, capsaicin, adenosine, endocannabinoids (such as N-arachidonic acid aminoethanol (anandamine) and 2-arachidonic acid glycerol (2 -AG)), erythropoietin (EPO) and other contents have significant changes, and any significant increase of any of these components reveals the improvement of the body's ability to withstand hypoxia. If there is no significant change in the above test results, a new round of repeated training of the first 5 programs will be carried out until any of the above blood components is improved (more than 10%).

After completing the training of the above 5 programs, in order to further consolidate the training results, you can choose to carry out the training of the 6th or 7th program according to the value of the brain oxygen saturation.

If the cerebral oxygen saturation is greater than 78%, the specific content of the plan is as follows: within the hypoxic range, set the sixth lowest concentration of oxygen, such as oxygen content of 12%, continue to supply oxygen for a period of time, such as 5 minutes of oxygen supply, low concentration After the oxygen supply stops, supply high-concentration oxygen, such as the oxygen content is 30%, continue to supply oxygen for a period of time, such as 1 minute, and then provide the sixth low-concentration oxygen, such as oxygen content is 12%, continue to supply oxygen for a period of time Time, such as 10 minutes, after the low-concentration oxygen supply stops, supply high-concentration oxygen, such as 30% oxygen, and continue to supply oxygen for a period of time, such as 1 minute; this is the sixth set of training programs, which continue every day The training was carried out 3 times for 20 consecutive days.

When the cerebral oxygen saturation is greater than 58% and less than 78%, the specific content of the plan is as follows: within the hypoxic range, set the seventh lowest concentration of oxygen, such as the oxygen content is 13%, continue to supply oxygen for a period of time, such as 5 minutes of oxygen supply, After the oxygen supply of low-concentration oxygen is stopped, supply high-concentration oxygen, such as the oxygen content is 40%, continue to supply oxygen for a period of time, such as 1 minute, and then provide the sixth low-concentration oxygen, such as oxygen content is 13%, continue to supply Oxygen for a period of time, such as 10 minutes, after the low-concentration oxygen supply stops, supply high-concentration oxygen, such as 40% oxygen, and continue to supply oxygen for a period of time, such as 1 minute; this is the seventh set of training programs. Continuous training was carried out 3 times a day for 20 consecutive days.

Apparently, the above-mentioned embodiments of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those of ordinary skill in the art can also make It is not possible to exhaustively list all the implementation methods here, and all obvious changes or changes derived from the technical solutions of the present invention are still within the scope of protection of the present invention.

Claims (10)

1. A pre-adaptation training method based on the combination of high and low oxygen, characterized in that the training method is based on the gas with different oxygen concentrations output by the pre-adaptation training system, which is inhaled by users with different durations and frequencies, so as to improve the body's ability to Acute ischemia/hypoxia tolerance, the pre-adaptation training system includes: The central processing unit (1), based on the pre-stored training program, sends control instructions to the high and low oxygen generating device (2), and establishes data communication with the remote network data platform (4) and the physiological parameter monitoring unit (3); The high and low oxygen generating device (2) receives control instructions from the central processing unit (1), and alternately outputs high-concentration oxygen or low-concentration oxygen; Physiological parameter monitoring unit (3), used to collect the physiological parameters of the user in the current state in real time; The remote network data platform (4) compares and analyzes the collected physiological parameters of the user in the current state based on the preset standard range of physiological parameters. 2. pre-adaptation training method according to claim 1, is characterized in that: described pre-adaptation training method comprises the steps: Store the training program in the pre-adaptation training system; Input user information into the pre-adaptation training system; Select the training program according to the input user information; start the high and low oxygen alternate breathing training and monitor the user's real-time physiological parameter values; If abnormality is detected in the real-time physiological parameters of the user during the training process, the training will be terminated immediately, and if the real-time physiological parameters of the monitored user are normal, the training will continue; After the training, detect the content of the target substance in the blood and compare it with the detected value before the training; When the content of any target substance in the blood reaches the predetermined standard or the cumulative number of training days reaches 180 days, the training ends. 3. The training method according to claim 2, wherein the training program includes the concentration of oxygen in the gas inhaled by the user, the duration of inhaling the gas, and the alternating frequency of inhaling gases with different oxygen concentrations. 4. The training method according to claim 2, characterized in that: said selection of training programs includes determining how many sets of training programs to execute, the manner and times of execution of each training program. 5. The training method according to claim 2, characterized in that: the high and low oxygen alternate breathing training means that the training system alternately outputs the gas supply with an oxygen concentration of 9-19%, 19-23% or 23-93%. User inhales. 6. The training method according to claim 3, characterized in that: the concentration range of oxygen in the gas inhaled by the user is 9-19%, 19-23% or 23-93%; the duration of the inhaled gas is 3-10min, the alternating frequency of inhaling gases with different oxygen concentrations is 1-5 times. 7. The training method according to claim 2, wherein the real-time physiological parameters include electrocardiogram, blood pressure, cerebral oxygen saturation, blood oxygen saturation and respiratory rate. 8. The training method according to claim 2, characterized in that: the user information includes the user's basic information and the physiological parameter values before the user's training, and the user's basic information includes at least the user's height and weight information; Parameters include ECG, blood pressure, cerebral oxygen saturation, blood oxygen saturation, and respiratory rate. 9. The training method according to claim 8, characterized in that: the targets in the blood include nitric oxide, bradykinin, endogenous opioids, hypoxia-inducible factor, capsaicin, adenosine , endogenous cannabinoids and erythropoietin; said when the content of any target substance in the blood reaches a predetermined standard refers to when the content of any target substance in the blood increases by more than 10%. 10. The pre-adaptation training method according to claim 1, characterized in that: the central processing unit (1) includes: A storage module (57), used for storing standard training programs or customized training programs; GSM communication module (7), used to establish data communication with the remote network data platform; The first Bluetooth communication module (8), used for the physiological parameter monitoring unit to establish data communication, and receive the user's physiological parameters in the current state of the user; The command sending module (63), based on the training program or the comparison and analysis results of the remote network data platform, sends control commands to the high and low oxygen generating device; Human-machine interface (6) for man-machine interaction; and An alarm module (62) for alarming and prompting based on the physiological parameter comparison results of the remote network data platform; Wherein, the physiological parameters include: ECG data, blood pressure data, cerebral oxygen saturation data, blood oxygen saturation data and respiratory state data; Wherein, the remote network data platform 4 includes: The basic information entry module (50), which saves the basic user information entered by the central processing unit; ECG data management unit (52), used to acquire and save ECG data during user training; Blood oxygen saturation data management unit (53), used to obtain and save the blood oxygen saturation value of the user at a certain training moment; A brain oxygen saturation data management unit (54), used to acquire and save the brain oxygen saturation data of the user at a certain training moment; A blood pressure data management unit (55), used to acquire and save the user's blood pressure data; and A respiratory rate management unit (56), used for obtaining and saving the respiratory rate during the training process of the user; and An alarm and alert data setting module (51), which sets the normal range threshold of physiological parameters; The comparison module (58), based on the normal range threshold of the physiological parameters, compares the real-time physiological parameters transmitted by the central processing unit to obtain a comparison result; Wherein, the high and low oxygen generating device (2) includes: air inlet (48); Oxygen production module (15), used for producing oxygen; Nitrogen production module (22), used for producing nitrogen; The first mass flow controller (17) adjusts the flow of oxygen generated by the oxygen generating module based on a preset flow value or an external control command; The second mass flow controller (24) adjusts the flow rate of nitrogen generated by the nitrogen generating module based on a preset flow value or an external control command; Gas mixing unit; mix the oxygen generated by the oxygen generating module and the nitrogen generated by the nitrogen generating module into a mixed gas with different high and low oxygen concentrations that meets the training requirements; and Air outlet (47); Further, the high and low oxygen generating device also includes a gas generator controller (26) for controlling gas flow; The gas generator controller (26) includes A data communication module for establishing data communication with the central processing unit 1; A comparative analysis module for comparing the concentration and flow of oxygen output by the current oxygen generation module or the pressure, flow, and oxygen concentration of the mixed gas output by the current high and low oxygen generating device with the preset standard value; and Based on the comparison result, a control signal sending module that sends a control signal.