CN105498073A - Degradable implantation catheter carrying drug particles - Google Patents

Abstract

The invention discloses a degradable implanted catheter carrying specific drug particles (iodine-125 seed source and slow-release drug particles such as fluorouracil sustained-release agent particles, etc.), including a catheter body for containing drug particles and a catheter body. The spacer used to separate the drugs, the degradable implant catheter carrying drug particles of the present invention can be filled with a sufficient amount of anti-tumor drugs and implanted into the tumor site of the patient together with the drugs, by making the anti-tumor The drug particles can reach the predetermined distribution in the tumor, do not enter the blood vessel and be washed away, and can still maintain the predetermined distribution in the tumor body fluid and necrotic cavity. When the tumor shrinks after the catheter is degraded, the implanted drug particles can follow the tumor accordingly. Change the site without leaving it outside the treatment site.

Description

Degradable implantable catheter carrying drug particles

technical field

The invention relates to the medical field, in particular to a degradable implant catheter carrying drug particles.

Background technique

Local placement of antineoplastic drugs can better overcome the defects of low local dose, poor effect and high systemic toxicity of traditional solid tumor treatment. However, the drug is placed directly on the tumor tissue and distributed according to the plan, which is not only difficult to operate, but also requires frequent implantation operations, which takes a long time and increases the risk of trauma and treatment.

Therefore, there is a need for a degradable implant catheter carrying drug particles, which is used to accommodate anti-tumor drugs, and then implanted with anti-tumor drugs into the patient's tumor site, and a sufficient amount of Anti-tumor drugs and realize the reasonable distribution of drug particles to achieve the best therapeutic effect. The degradability helps to realize that the drug particles can gradually accumulate with the tumor as the tumor shrinks, and will not enter the surrounding tissue.

Contents of the invention

In view of this, the object of the present invention is to provide a degradable implant catheter carrying drug particles, which can be filled with a sufficient amount of anti-tumor drugs and implanted into the patient's tumor cells together with the drugs, through the slow release of anti-tumor drugs Achieve long-term treatment and save treatment costs.

The degradable implantable catheter carrying drug particles of the present invention comprises a catheter body for containing drugs and a spacer block arranged in the catheter body for separating the drugs.

Further, both the catheter body and the spacer are made of degradable materials.

Further, the inner diameter of the catheter body is 0.9-1.0mm, and the wall thickness is 0.08-0.12mm.

Further, the side wall of the conduit body is provided with at least one side hole or the opening of the side wall of the conduit body is formed into a C-shaped tube structure.

Further, the distance between the side holes along the length of the catheter body is 10-20mm.

Further, one end of the catheter body is closed, and the other end is in the shape of a bell mouth, and the closed end is flat, pointed, round and may be bifurcated.

Further, the degradable material is bioerodible or biodegradable metal, alloy or polymer.

Further, the degradable material is magnesium, iron, magnesium-based alloy, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer, polyamide, polyester, polyester amide, polyanhydride, polyorthoester, poly Phosphazenes, pseudopolyamino acids, polyglycerol-sebacate, polycaprolactone, polycaprolactone derivatives, aminoalcohol-based polyesteramides, polyoctanediol citrate, hydrogels or curable bioresorbable elastomers.

The beneficial effects of the present invention are: the degradable implant catheter carrying drug particles of the present invention can be loaded with a sufficient amount of anti-tumor drugs and implanted into the patient's tumor cells together with the drug through the degradable implant catheter carrying drug particles Long-term treatment can be achieved through the slow release of anti-tumor drugs, saving treatment costs.

Description of drawings

Fig. 1 is a structural schematic diagram of the present invention.

detailed description

Fig. 1 is a schematic structural diagram of the present invention; as shown in the figure: the degradable implantable catheter carrying drug particles in this embodiment includes a catheter body 2 for containing a drug 1 and a catheter body 2 for dispensing the drug 1 Spacer blocks 3 spaced apart; the catheter body 2 is a flexible tubular structure with a certain hardness, and the drug 1 can be released from the nozzle at the end of the catheter body 2, and holes can also be processed on the side wall of the catheter body 2 to make the drug 1 The purpose of the present invention can be achieved by being released from the hole; the length and interval of the spacer block 3 can be reasonably set according to the diseased part, and then the medicine 1 can be made to correspond to the diseased part after the catheter body 2 is implanted into the human body, which can reasonably Administer 1 dose of the drug and ensure the therapeutic effect.

In this embodiment, the catheter body 2 and the spacer 3 are made of degradable materials; the catheter body 2 and the spacer 3 can be gradually absorbed by the human body after implantation, which simplifies the treatment process and reduces damage to the human body.

In this embodiment, the inner diameter of the catheter body 2 is 0.9-1.0mm, and the wall thickness is 0.08-0.12mm; the tube diameter is small and the wall thickness is thin, which is suitable for implantation through a puncture needle, which is conducive to degradation and absorption; it can be used to accommodate diameters Cylindrical drug particles of about 0.8mm are delivered through a puncture needle to ensure the ideal distribution of therapeutic drugs.

In this embodiment, at least one side hole 4 is provided on the side wall of the catheter body 2 or the opening of the side wall of the catheter body 2 is formed into a C-shaped tube structure; that is, one to several side holes 4 are opened on the side wall of the catheter body 2 Part of the side wall of the catheter body 2 is cut off to form a C-shaped tube structure, and the size and density of the side holes 4 are reasonably set according to the absorbability of the drug 1, or the width of the side opening of the C-shaped tube is reasonably set according to the absorbability of the drug 1, and one of the side holes 4 It is located at the bottom of the catheter body 2, so that the air is removed when the drug 1 is filled, so that the drug can be filled and released gradually to act on the diseased part. The radial direction gradually becomes larger from the inside to the outside, which can better control the release duration of the drug 1, increase the area of action at the same time, and improve the therapeutic effect; the side holes 4 corresponding to the catheter body 2 except the lowest end are provided with seals on the side holes 4. The diaphragm at the outer end of part of the side hole 4, the diaphragm is integrally formed with the catheter body 2 and the diaphragm is flat with the outer surface of the catheter body 2, and the diaphragm is made of bioerodible or biodegradable metal, alloy or polymer , the side hole 4 can be sealed by the diaphragm to prevent the drug 1 from spilling before implantation, so the drug 1 can be powder or liquid, and the diaphragm is set to make the outer surface of the catheter body 2 smooth, which is convenient for implantation. The rear membrane is preferentially degraded, so that the side hole 4 is opened to realize the release of the drug 1 .

In this embodiment, the distance between the side holes 4 along the length of the catheter body 2 is 10-20 mm; the drug 1 can directly act on the patient's position, improve the therapeutic effect, reduce the dosage of the drug, and reduce the side effects of the drug.

In this embodiment, one end of the catheter body 2 is closed, and the other end is in the shape of a bell mouth. The closed end is flat, pointed, round and can be bifurcated; Setting the closed end in a bifurcated shape can increase the area of action of the drug 1, and at the same time use the bifurcated structure to effectively position the catheter body 2 to avoid displacement of the catheter body 2 and ensure the therapeutic effect.

In this embodiment, the degradable material is a bioerodible or biodegradable metal, alloy or polymer; the catheter body 2 can be gradually absorbed by the human body after implantation, which simplifies the treatment process and reduces damage to the human body.

In this embodiment, the degradable material is magnesium, iron, magnesium-based alloy, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer, polyamide, polyester, polyester amide, polyanhydride, polyorthoacid Esters, polyphosphazenes, pseudopolyamino acids, polyglyceryl-sebacate, polycaprolactone, polycaprolactone derivatives, aminoalcohol-based polyesteramides, polyoctanediol citrate, hydrogels or curable bioresorbable elastomers; PC-based polymers require additional crosslinkers such as lysine diisocyanate or 2,2-bis(ε-caprolactone-4-yl)propane for elasticity Body properties, copolymers, mixtures and combinations of the above materials can also be used, the components of the hydrogel include corn starch 4.5-4.7, acrylic acid 21.4-22.5, acrylamide 9-9.5, ammonium persulfate 3.2- 4.5, calcium carbonate 4.5-4.7, sodium hydroxide 9.5-9.9, water balance, that is, except corn starch, acrylic acid, acrylamide, ammonium persulfate, calcium carbonate, and sodium hydroxide, the rest is water; when preparing hydrogel , first dissolve sodium hydroxide in water, and add acrylic acid for pretreatment; then add cornstarch, acrylamide and calcium carbonate in turn, stir and heat for reaction, add initiator to carry out graft polymerization reaction; then the liquid after reaction Pour it into a mold and dry it at a constant temperature; it has the advantages of simple process, non-toxic product, fast biodegradation speed and wide application.

Finally, it is noted that the above embodiments are only used to illustrate the technical solutions of the present invention without limitation. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be carried out Modifications or equivalent replacements without departing from the spirit and scope of the technical solution of the present invention shall be covered by the claims of the present invention.

Claims (8)

1. carry a degradable implantation catheter for drug particle, it is characterized in that: comprise catheter body for holding medicine and be located in catheter body for by spacer block spaced apart for medicine.

2. the degradable implantation catheter carrying drug particle according to claim 1, is characterized in that: described catheter body and spacer block are made by degradation material.

3. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: the internal diameter of described catheter body is 0.9 ~ 1.0mm, and wall thickness is 0.08 ~ 0.12mm.

4. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: described catheter body sidewall arranges at least one side opening or catheter body sidewall opening is formed C type tubular construction.

5. the degradable implantation catheter carrying drug particle according to claim 4, is characterized in that: described side opening along catheter body length to spacing be 10 ~ 20mm.

6. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: one end of described catheter body is closed, and the other end is bell mouth shape, and its blind end is tack, tip, round end and can be forked.

7. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: described degradation material for separating or biodegradable metal, alloy or polymer in biological erosion.

8. the degradable implantation catheter carrying drug particle according to claim 2, is characterized in that: described degradation material be magnesium, ferrum, magnesium base alloy, polylactic acid, polyglycolic acid, polylactic-co-glycolic acid, polyamide, polyester, polyesteramide, polyanhydride, poe, polyphosphazene, false polyamino acid, polyglycereol-sebacate, polycaprolactone, polycaprolactone derivatives, based on amino alcohol polyesteramide, poly-octane glycol citrate, hydrogel or curable biology can resorbent elastomers.