CN105495153B - A kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e - Google Patents
A kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e Download PDFInfo
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Abstract
The present invention relates to a kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e, it is characterised in that contain phycocyanin and ginkgo biloba p.e containing it, weight ratio is phycocyanin：Ginkgo biloba p.e=1~10:1~10, it proves that the Halth-care composition has the antioxidant activity better than single extract by pharmacological experiment study, can be used as the antioxidant health-care product for effectively improving function of human body.
Description
Technical field
The present invention relates to food, health products and pharmaceutical fields.
Background technology
Health products are the food for having specific healthcare function, being only suitable for specific crowd, but not for the purpose for the treatment of disease, are protected
The function of strong product includes：Immunological regulation adjusts blood fat, adjusts blood glucose, anti-aging, improve memory, promote lead discharging, adjust blood
Pressure, improve sleep, anti-mutation, it is antifatigue, improve osteoporosis, improve alimentary anemia, improve gastrointestinal function etc..But it is existing
Health products arranged in pairs or groups science not to the utmost due to its component, therefore it is improving human body totality function, anti-oxidant, antifatigue etc. to also have
It waits further increasing.
The oxidation of biomolecule is the process of a free radical mediated, and it is many unfavorable that it can cause food and biosystem
Influence.In aerobic organ, with the relevant free free radical of a variety of diseases such as artery sclerosis, cancer can inevitably with
The process of oxygen metabolism and generate.In vivo, antioxidation plays important function in terms of maintaining body health.It is logical
Normal antioxidant (free radical scavenger) provides electronics to free radical keeps asymmetric electronic stability pairs of.In this case,
Although antioxidant itself becomes free radical, which is typically stable, and can be converted by all means it is non-from
By base.Therefore, it is always the research hotspot of biochemical nutrition to find safe antioxidant to inhibit the generation of peroxide.
The chemical syntheses such as BHT, TBHQ antioxidant is due to good antioxidant effect and suitable price, being widely used in always
Food, pharmaceuticals industry.But with the continuous improvement of human living standards, people are to the green pure natural anti-oxidation from nature
The demand of agent is constantly soaring.
Phycocyanin is one of chromoprotein rare from a kind of nature isolated in spirulina, and not only color is fresh
It is gorgeous, and be a kind of protein full of nutrition in itself, amino acid composition is complete, it is necessary to which amino acid content is high.
Phycocyanin has anticancer, promotes cell substitution, conserves ovary, promoting the work(such as synthesis elastin in human body
Effect.Phycocyanin may also help in adjusting, synthesized human is metabolized required a variety of important enzymes, to inhibiting the growth of cancer cell
Play an important roll with synthesis elastin in the regeneration of promotion human body cell, maintenance ovary, promotion human body, while phycocyanin tune
Human immune system is saved, function of immune system is enhanced, resistance of the human body to disease is improved, promotes cell activity, is removed internal
Free radical improves ovarian function, promotes human body Fast back-projection algorithm elastin.
Ginkgo biloba p.e be using the leaf of ginkgo Ginkgo biloba L. as raw material, using solvent appropriate, extraction
A kind of product of active ingredient enrichment.Using ginkgo biloba p.e as various preparations made of raw material, it is widely used in drug, health care
The fields such as product, food additives, functional beverage, cosmetics.
Ginkgo biloba p.e can promote the cycle of brain and body limbs simultaneously, inhibit platelet activating factor (PAF), drop
Low platelet is assembled, and protection nerve cell is injury-free, which plays the role of auxiliary treatment for the patient of apoplexy.In addition to suppression
Outside thrombocyte adhesiveness processed, ginkgo biloba extract can also adjust antiotasis and elastic force, promote the big blood vessel (artery) in the circulatory system
With the cycle efficieny compared with thin vessels (capillary)；Ginkgo biloba p.e may be in brain, eyeball retina and cardiovascular system
In can play anti-oxidation characteristics.Its antioxidation in brain and central nervous system potentially contributes to prevent from leading because of the age
The cerebral function of cause declines.Brain and central nervous system are particularly vulnerable to free radical attack.Free radical causes brain damage wide
The influence factor of the general a variety of diseases for being considered to cause to come with aging, wherein even including Alzheimer's disease；Ginkgo leaf carries
It takes object to promote cerebral blood flow and has fabulous tonic effect to nervous system.Include hundreds of secondary scientific research cards of patients up to ten thousand
The effect of real ginkgo biloba p.e, is to the problems including cerebral blood flow is insufficient and the intelelectual deterioration of gerontal patient
Effect.Ginkgo has good effect to the possibility symptom of many agings, such as：Anxiety and melancholy, are difficult to concentrate memory impairment
Attention, dexterity declines, intelligence declines, dizziness, headache tinnitus (ring in ear), macula retinae portion degeneration (adult's blindness
Most common reason), inner ear disturbance (its can cause part become deaf), end cycle it is bad etc..
Invention content
The purpose of the present invention is to provide a kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e, passes through medicine
Reason improves antioxidant activity it is demonstrated experimentally that phycocyanin can act synergistically with ginkgo biloba p.e compatibility, and it is blue to play algae
The strengthen immunity of albumen, the clearing and activating the channels and collaterals of antifatigue effect and ginkgo biloba p.e, the function of promoting blood circulation.To
Integrally-regulated function of human body improves health quality.
The technical scheme is that：
A kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e is extracted containing phycocyanin and ginkgo leaf
Object, weight ratio are phycocyanin：Ginkgo biloba p.e=1~10:1~10, or be 1-10 parts of phycocyanin in parts by weight
With 10-1 parts of ginkgo biloba p.e.Preferably weight ratio is：Phycocyanin：Ginkgo biloba p.e=1:1 or phycocyanin：Silver
Apricot leaf extract=1:2 or phycocyanin：Ginkgo biloba p.e=2:1.
Antioxidant health-care product of the present invention, wherein the content of the total Content of Flavone Glycosides from Ginkgo biloba Extract alcohol glycosides is with weight
Meter no less than 20%.
Antioxidant health-care product of the present invention further contains food and pharmaceutically acceptable auxiliary material, additive
And/or excipient.
The antioxidant health-care product of the present invention has higher antioxidant activity, can strengthen immunity, antifatigue, promoting menstruation work
Network promotes blood circulation.
Description of the drawings
Fig. 1 is that the cell viability between different experiments group compares.
Specific implementation mode
To more fully understand the essence of the present invention, it is described below by better embodiment of the present invention, in detail
Illustrate the present invention but does not limit the present invention.
The material and reagent used in following embodiment removes specified otherwise, is common commercially available.
Embodiment 1：Medicine preparation
Phycocyanin (lot number：20131201, with nitrogen content be calculated as 25%), ginkgo biloba p.e (lot number：20131103,
Using total flavonoids content be calculated as 31%) manufacturer as Shenzhen Haiwang Pharmaceutical Co., Ltd.
The content of phycocyanin is measured according to n2 method (2010 editions second methods of annex IX L of Chinese Pharmacopoeia).
The content of total Content of Flavone Glycosides from Ginkgo biloba Extract alcohol glycosides is shone total under 2010 editions ginkgo biloba p.e items of Chinese Pharmacopoeia
The content assaying method of flavonol glycosides measures.
Phycocyanin, ginkgo biloba p.e are directly prepared into following composition according to a certain ratio.
Composition 1：Phycocyanin is 1 with ginkgo biloba p.e weight ratio:1；
Composition 2：Phycocyanin is 2 with ginkgo biloba p.e weight ratio:1；
Composition 3：Phycocyanin is 1 with ginkgo biloba p.e weight ratio:2；
Embodiment 2：H2O2Cause preparation and the drug-treated of pancreas islet RI N-m model of cell apoptosis
Cell is with every hole 105The density of/mL is inoculated in 96 well culture plates, 37 DEG C, volume fraction 5%CO2, saturated humidity
Under the conditions of overnight incubation keep cell completely adherent.Blank group, model group (H are set respectively2O2), ginkgo biloba p.e group (30 μ g/ml；
60 μ g/ml), phycocyanin group (30 μ g/ml；60 μ g/ml), ginkgo leaf and phycocyanin mixture group, every group of at least 6 holes.Medicine
Object is in 37 DEG C, after incubating 10h in advance, adds the H of final concentration of 500 μm of ol/L2O2Continue to cultivate 6h, then MTT methods is utilized to measure
Cell viability.At least 3 repeated experiments.It the results are shown in Table 1 and Fig. 1：
Cell viability between the different groups of table 1. compares (Mean ± S.D., n=4)
Experimental data shows that ginkgo biloba p.e all has different degrees of antioxidation with phycocyanin, passes through respectively
The cell for crossing extract pre-administration can cell death caused by different degrees of resistance peroxide.Ginkgo biloba p.e is anti-oxidant
Effect is slightly above phycocyanin.
After ginkgo biloba p.e matches in varing proportions with phycocyanin, antioxidation increases substantially, such as will be respective
After closing use with 30 μ g/ml, cell viability is significantly higher than respectively with the adduction of 30 μ g/ml effects.It will be respectively with 60 μ g/ml's
After concentration is used in combination, cell viability is significantly higher than respectively with the adduction of 60 μ g/ml effects.By two kinds of compounds with different
After ratio mixing, respectively inhibition peroxide causes the ability of cell death equally to add higher than what corresponding respectively concentration acted on respectively
With.
Result above prompts, and ginkgo leaf extraction, in antioxidation, may act on no way with phycocyanin
Diameter or no action site, there are synergistic effects for the two use in conjunction, and the two use in conjunction effect is better than exclusive use effect.
It is prepared by 3 tablet of embodiment
Starch, microcrystalline cellulose, lactose will will be added in the 1 of weight ratio part of phycocyanin, 1 part of ginkgo biloba p.e
The one or more of equal auxiliary materials, mixing are pelletized, and are dried, sieving, tabletting, every weight 0.2-0.5g, the present invention tablet.
It is prepared by 4 oral solution of embodiment
It will be dissolved in water in 1 part of phycocyanin of weight ratio, 2 parts of ginkgo biloba p.es, simple syrup, nipalgin be added
Ester, benzoic acid, it is filling in coloured glass bottle after mixing, the present invention oral solution.
It is prepared by 5 capsule of embodiment
Starch, microcrystalline cellulose, lactose will will be added in the 1 of weight ratio part of phycocyanin, 1 part of ginkgo biloba p.e
The one or more of equal auxiliary materials, mixing are pelletized, and are dried, and sieving is encapsulated, every capsule 's content weight 0.2-0.5g, i.e. cost
The capsule of invention.
The above detailed description of the present invention is not intended to limit the present invention, and those skilled in the art can make according to the present invention
Various changes and variants should all belong to the scope of the present invention without departing from the spirit of the present invention.
Claims (6)
1. a kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e, it is characterised in that：By phycocyanin and ginkgo
Leaf extract is made, and weight ratio is phycocyanin：Ginkgo biloba p.e=1~2:1~2.
2. antioxidant health-care product as described in claim 1, it is characterised in that the total Content of Flavone Glycosides from Ginkgo biloba Extract alcohol glycosides
Content is no less than 20% by weight.
3. antioxidant health-care product as described in claim 1, it is characterised in that consisting of：Phycocyanin by weight：Ginkgo
Leaf extract=1:1.
4. antioxidant health-care product as described in claim 1, it is characterised in that consisting of：Phycocyanin by weight：Ginkgo
Leaf extract=1:2.
5. antioxidant health-care product as described in claim 1, it is characterised in that consisting of：Phycocyanin by weight：Ginkgo
Leaf extract=2:1.
6. such as Claims 1 to 5 any one of them antioxidant health-care product, it is characterised in that further containing food or pharmaceutically
Acceptable auxiliary material, additive and/or excipient.
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| CN109497483A (en) * | 2018-01-26 | 2019-03-22 | 中国科学院烟台海岸带研究所 | One kind is containing phycocyanin and pine pollen composition and its preparation and application |
| CN109329934A (en) * | 2018-12-10 | 2019-02-15 | 丽江程海湖天然螺旋藻生产基地有限公司 | A kind of ginkgo spiral algae sheet of strengthen immunity and preparation method thereof |
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| CN101433574A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Composition with function for alleviating eyestrain and preparation method thereof |
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| CN101856374A (en) * | 2010-06-11 | 2010-10-13 | 青岛农业大学 | an anti-aging composition |
| CN103992402A (en) * | 2014-04-30 | 2014-08-20 | 中国药科大学 | Preparation method of high-purity phycocyanin |
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| CN1593562A (en) * | 2004-07-05 | 2005-03-16 | 深圳海王药业有限公司 | Ginkgo leaf extract composition |
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| CN101433574A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Composition with function for alleviating eyestrain and preparation method thereof |
| CN101703536A (en) * | 2009-07-22 | 2010-05-12 | 青岛农业大学 | Antitumor medicament with combination of spirulina polysaccharide and ginkgo-leaf effective components |
| CN101856374A (en) * | 2010-06-11 | 2010-10-13 | 青岛农业大学 | an anti-aging composition |
| CN103992402A (en) * | 2014-04-30 | 2014-08-20 | 中国药科大学 | Preparation method of high-purity phycocyanin |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023156066A1 (en) * | 2022-02-17 | 2023-08-24 | The Boots Company Plc | Antioxidant compositions |
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