CN105475340A - Bactericidal composition containing silthiopham and metalaxyl and application thereof - Google Patents
Bactericidal composition containing silthiopham and metalaxyl and application thereof Download PDFInfo
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- CN105475340A CN105475340A CN201510996397.9A CN201510996397A CN105475340A CN 105475340 A CN105475340 A CN 105475340A CN 201510996397 A CN201510996397 A CN 201510996397A CN 105475340 A CN105475340 A CN 105475340A
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- Prior art keywords
- metalaxyl
- silthiopham
- bactericidal composition
- composition according
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- 239000005807 Metalaxyl Substances 0.000 title claims abstract description 84
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 title claims abstract description 84
- MXMXHPPIGKYTAR-UHFFFAOYSA-N silthiofam Chemical compound CC=1SC([Si](C)(C)C)=C(C(=O)NCC=C)C=1C MXMXHPPIGKYTAR-UHFFFAOYSA-N 0.000 title claims abstract description 84
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 31
- 208000031888 Mycoses Diseases 0.000 claims abstract description 11
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000000375 suspending agent Substances 0.000 claims description 8
- 238000009736 wetting Methods 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 239000006185 dispersion Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000003905 agrochemical Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 10
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 235000013311 vegetables Nutrition 0.000 abstract description 4
- 235000013339 cereals Nutrition 0.000 abstract description 3
- 239000000575 pesticide Substances 0.000 abstract description 2
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- -1 diffusant Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 14
- 239000003921 oil Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- 239000004530 micro-emulsion Substances 0.000 description 9
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 5
- 229920000056 polyoxyethylene ether Polymers 0.000 description 5
- 229940051841 polyoxyethylene ether Drugs 0.000 description 5
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- 241000233622 Phytophthora infestans Species 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 229910021653 sulphate ion Inorganic materials 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 241000233654 Oomycetes Species 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 1
- 241001163841 Albugo ipomoeae-panduratae Species 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 241000233647 Phytophthora nicotianae var. parasitica Species 0.000 description 1
- 241000233629 Phytophthora parasitica Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- DAUYIKBTMNZABP-UHFFFAOYSA-N thiophene-3-carboxamide Chemical compound NC(=O)C=1C=CSC=1 DAUYIKBTMNZABP-UHFFFAOYSA-N 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing silthiopham and metalaxyl and an application thereof. The bactericidal composition takes silthiopham and metalaxyl as the main active ingredients, wherein the mass ratio of silthiopham to metalaxyl is (1-70) to (1-50). The bactericidal composition can be applied to controlling cereal, fruit tree and vegetable diseases, especially can be used for controlling fungal diseases, such as wheat take-all, downy mildew and late blight, has higher synergistic effects, has the effects of overcoming and delaying the pesticide resistance of germs, is high in bactericidal speed, has long lasting period, has the effect of reducing the application cost and has obviously better control effects than other single agents.
Description
Technical field:
The present invention relates to a kind of bactericidal composition and uses thereof, especially a kind of be main active bactericidal composition and the application thereof of Silthiopham and metalaxyl.
Background technology
Silthiopham (Silthiopham), chemical name: N-pi-allyl-4,5-dimethyl-2-(TMS) thiophene-3-formamide.Silthiopham has good prolection, and the longevity of residure is long, all safer to crop, mammal and environment, has special efficacy to take-all.
Metalaxyl (Metalaxyl), molecular formula: C
15h
21nO
4, chemical name: N-(2-Methoxyacetyl)-N-(2,6-3,5-dimethylphenyl)-DL-alpha-aminopropanoate.Structural formula:
Metalaxyl is new and effective systemic fungicide.Can interior inspiration enter in plant, the general bactericide of water-soluble ratio be much higher.To the downy mildew in Oomycete and phytophthora, there is selectivity special efficacy, have good control efficiency to potato late blight, downy mildew of garpe, hop downy mildew, beet epidemic disease, white rust of colza, black shank etc.Also can be used for cotton damping off, the millet downy mildew, control efficiency is good.
The difficulty of prevention and cure of current phytopathogen is increasing, and on the one hand, along with the change of pattern of farming, the economic crops such as melon and fruit, vegetables cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under the medicament selection pressure continued, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention:
The object of the invention is the plant bactericidal composition containing Silthiopham and metalaxyl providing a kind of applied widely, cost low, effective for above-mentioned technical problem.
A further object of the invention is to provide this bactericidal composition and causes application on fungal disease at control plant epiphyte, is is especially preventing and treating the purposes on the fungal diseases such as take-all, downy mildew, late blight.
The object of the invention is to be achieved through the following technical solutions:
A kind of bactericidal composition containing Silthiopham and metalaxyl, this bactericidal composition with Silthiopham and metalaxyl for principle active component, wherein the mass ratio of Silthiopham and metalaxyl is 1 ~ 70:1 ~ 50, and wherein in bactericidal composition, effective ingredient is present in composition with enhancing effective amount.
Described bactericidal composition, wherein the mass ratio of Silthiopham and metalaxyl is preferably 1 ~ 50:1 ~ 20, more preferably 1 ~ 30:1 ~ 20, is further preferably 1 ~ 20:1 ~ 10.
The preferred mass proportioning of Silthiopham and metalaxyl also can be: 70:1,50:1,30:1,20:1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50.
In the compositions of the present invention, the mass percentage accounting for composition both Silthiopham and metalaxyl is 2 ~ 80%.Preferably 5 ~ 70%.
Described bactericidal composition, wherein with Silthiopham and metalaxyl for principle active component and known auxiliary agent and excipient are re-dubbed any one formulation that agricultural chemicals allows.These known auxiliary agents, excipients has dispersant, diffusant, defoamer, wetting agent, disintegrant etc., calcium dodecyl benzene sulfonate can be adopted, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, the rare block compound of polyoxyethylene polyoxy third, castor oil polyoxyethylene ether, polyoxyethylene nonylphenol ether, TWEEN Series, fatty alcohol-polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulphate, phosphate, phosphite, lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, one or more combinations in quaternary etc., excipient comprises cyclohexanone, dimethylbenzene, various solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can be alone or and use.
Described bactericidal composition, its formulation is missible oil, wetting powder, suspending agent, aqueous emulsion or water dispersion granule.
The application of above-mentioned bactericidal composition on preparation control fungal diseases of plants medicine.Especially in control Cereal, fruit tree, vegetable crop disease, application has remarkable result.
Above-mentioned application, described fungal diseases of plants is at least one in take-all, downy mildew, late blight.
The feature of bactericidal composition of the present invention:
1, the Silthiopham that the present invention is used and metalaxyl, mutual mixture can not produce conflict, can Synergistic, reduces dosage, reduces costs.
2, the present composition scope of application increases, and be applicable to the refractory fungal disease of preventing and treating Cereal, fruit tree, vegetables, particularly preventing and treating take-all, downy mildew, late blight etc. all has significant effect.Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; And suppress insect or fungi to the drug-fast generation of unitary agent (Silthiopham and metalaxyl arbitrary).Bactericidal composition of the present invention can produce higher synergistic function, and the consumption of the independent reactive compound of the amount ratio of this mixture reduces greatly, and namely the activity of mixture is greater than the activity of independent component.
Compared with prior art beneficial effect of the present invention: (1) is compared with single dose, said composition antagonism fungal disease such as the fungal diseases such as take-all, downy mildew, late blight have obvious synergistic function, overcome and delayed pesticide resistance, expanding prevention is composed, and significantly improves control efficiency; (2) control recruitment, drug cost is reduced; (3) alternative routine and the easy agricultural chemicals producing resistance; (4) compared with single dose, produce and use cost reduction; (5) the drug-fast generation of Antifungi, its successful uses higher than its single dose.
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method, and " % " of the present invention is mass percent.
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure different agents to the EC of bacterial strain
50value, adopt co-toxicity coefficient computational methods, calculate the co-toxicity coefficient (CTC) of mixture, determine the building performance of mixture, circular is as follows:
With single dose a certain in mixture for standard agent (selects EC usually
50junior), calculate:
Single dose toxicity index=standard agent EC
50/ certain single dose EC
50× 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When co-toxicity coefficient classification: CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80-120.
According to active ingredient Silthiopham (A): metalaxyl (B) quality proportioning is: 80:1,70:1,50:1,30:1,20:1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50,1:60 test, measure its co-toxicity coefficient to Phytophthora infestans germ (Phytophthorainfestans (Mont.) deBary).
Table 1: Silthiopham+metalaxyl different ratio is to the indoor biometrics result of Phytophthora infestans germ
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 12.5% Silthiopham SC | Y＝4.153+1.547X | 3.526 | - |
| 25% metalaxyl WP | Y＝4.438+2.302X | 1.754 | - |
| A:B＝80:1 | Y＝3.665+2.569X | 3.309 | 105.23 |
| A:B＝70:1 | Y＝4.406+1.334X | 2.786 | 124.78 |
| A:B＝50:1 | Y＝4.470+1.563X | 2.182 | 158.46 |
| A:B＝30:1 | Y＝4.094+2.254X | 2.522 | 135.42 |
| A:B＝20:1 | Y＝4.208+2.639X | 1.995 | 168.59 |
| A:B＝10:1 | Y＝4.723+1.096X | 1.790 | 180.40 |
| A:B＝5:1 | Y＝4.717+1.452X | 1.567 | 192.65 |
| A:B＝2.5:1 | Y＝4.429+2.069X | 1.887 | 145.01 |
| A:B＝1:1 | Y＝4.770+1.387X | 1.464 | 160.02 |
| A:B＝1:2 | Y＝4.825+2.993X | 1.144 | 184.14 |
| A:B＝1:4 | Y＝4.850+1.241X | 1.320 | 147.72 |
| A:B＝1:6 | Y＝4.625+2.654X | 1.384 | 136.56 |
| A:B＝1:10 | Y＝4.867+1.505X | 1.225 | 150.02 |
| A:B＝1:20 | Y＝4.639+2.489X | 1.396 | 128.75 |
| A:B＝1:30 | Y＝4.860+1.047X | 1.362 | 130.89 |
| A:B＝1:50 | Y＝5.001+2.632X | 0.999 | 177.28 |
| A:B＝1:60 | Y＝4.685+1.245X | 1.791 | 98.76 |
Field control effectiveness test:
With the pesticidal preparations control tomato late blight test that above-described embodiment is obtained.
1, test process: this test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, contrast medicament is agricultural chemicals single dose 12.5% Silthiopham SC and 25% metalaxyl WP and blank clean water experiment respectively.
2, each plot area of test method is 66.7m
2, repeat 3 times; Investigation drug effect method before dispenser after Investigation and Prevention is: random sampling 5 point in test treatment region, carries out severity Scaling, calculate preventive effect according to national field trial relevant criterion.Result of the test is in table 2:
Table 2 field test effect
Shown by indoor biometrics and field efficacy result, Silthiopham and metalaxyl composition have obvious synergistic function, and the control efficiency of composition is excellent, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Two kinds of reactive compounds can be processed into any one formulation of permission, with specific embodiment, the preparation that two kinds of active ingredients are processed into are described below, but the preparation that these two kinds of active components can be processed be not limited only to following listed by.
Embodiment 1:15% Silthiopham metalaxyl wetting powder (1:2)
By Silthiopham 5g, metalaxyl 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained active ingredient mass percent is 15% Silthiopham metalaxyl wetting powder.
Embodiment 2:15% Silthiopham metalaxyl wetting powder (1:4)
By Silthiopham 3g, metalaxyl 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained active ingredient mass percent is 15% Silthiopham metalaxyl wetting powder.
Embodiment 3:14% Silthiopham metalaxyl wetting powder (1:6)
By Silthiopham 2g, metalaxyl 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained active ingredient mass percent is 14% Silthiopham metalaxyl wetting powder.
Embodiment 4:20% Silthiopham Metalaxyl suspending agent (1:1)
Take 10g Silthiopham, 10g metalaxyl, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make active ingredient mass percent is 20% Silthiopham Metalaxyl suspending agent.
Embodiment 5:55% Silthiopham metalaxyl aqueous emulsion (1:10)
Take 5g Silthiopham, 50g metalaxyl, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making active ingredient mass percent is 55% Silthiopham metalaxyl aqueous emulsion.
Embodiment 6:42% Silthiopham metalaxyl missible oil (1:20)
Take 2g Silthiopham, 40g metalaxyl, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient mass percent is 42% Silthiopham metalaxyl missible oil.
Embodiment 7:70% Silthiopham metalaxyl missible oil (2.5:1)
Take 50g Silthiopham, 20g metalaxyl, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor oil polyoxyethylene ether 2g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient mass percent is 70% Silthiopham metalaxyl missible oil.
Embodiment 8:18% Silthiopham metalaxyl water dispersion granule (5:1)
Take 15g Silthiopham, 3g metalaxyl, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% Silthiopham metalaxyl water dispersion granule that above raw material is made active ingredient mass percent by water dispersible granular agent method.
Embodiment 9:11% Silthiopham metalaxyl missible oil (10:1)
Take 10g Silthiopham, 1g metalaxyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient mass percent is 11% Silthiopham metalaxyl missible oil.
Embodiment 10:31.5% Silthiopham metalaxyl microemulsion (20:1)
Take 30g Silthiopham, 1.5g metalaxyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient mass percent is 32% Silthiopham metalaxyl microemulsion.
Embodiment 11:31% Silthiopham metalaxyl missible oil (30:1)
Take 30g Silthiopham, 1g metalaxyl, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient mass percent is 31% Silthiopham metalaxyl missible oil.
Embodiment 12:51% Silthiopham Metalaxyl suspending agent (50:1)
Take 50g Silthiopham, 1g metalaxyl, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make active ingredient mass percent is 51% Silthiopham Metalaxyl suspending agent.
Embodiment 13:32% Silthiopham metalaxyl microemulsion (1:15)
Take 2g Silthiopham, 30g metalaxyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient mass percent is 32% Silthiopham metalaxyl microemulsion.
Embodiment 14:6% Silthiopham metalaxyl aqueous emulsion (1:5)
Take 1g Silthiopham, 5g metalaxyl, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making active ingredient mass percent is 6% Silthiopham metalaxyl aqueous emulsion.
Embodiment 15:62% Silthiopham metalaxyl microemulsion (1:30)
Take 2g Silthiopham, 60g metalaxyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient mass percent is 62% Silthiopham metalaxyl microemulsion.
Embodiment 16:51% Silthiopham Metalaxyl suspending agent (1:50)
Take 1g Silthiopham, 50g metalaxyl, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make active ingredient mass percent is 51% Silthiopham Metalaxyl suspending agent.
Embodiment 17:7% Silthiopham metalaxyl water dispersion granule (1:2.5)
Take 2g Silthiopham, 5g metalaxyl, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, and it is 7% Silthiopham metalaxyl water dispersion granule that above raw material is made active ingredient mass percent by water dispersible granular agent method.
Claims (10)
1., containing a bactericidal composition for Silthiopham and metalaxyl, it is characterized in that this bactericidal composition with Silthiopham and metalaxyl for principle active component, wherein the mass ratio of Silthiopham and metalaxyl is 1 ~ 70:1 ~ 50.
2. bactericidal composition according to claim 1, is characterized in that the mass ratio of described Silthiopham and metalaxyl is 1 ~ 50:1 ~ 20.
3. bactericidal composition according to claim 2, is characterized in that the mass ratio of described Silthiopham and metalaxyl is 1 ~ 30:1 ~ 20.
4. bactericidal composition according to claim 3, is characterized in that the mass ratio of described Silthiopham and metalaxyl is 1 ~ 20:1 ~ 10.
5. bactericidal composition according to claim 1, is characterized in that the mass percentage that both described Silthiopham and metalaxyl account for composition is 2-80%.
6. bactericidal composition according to claim 5, is characterized in that the mass percentage that both described Silthiopham and metalaxyl account for composition is 5-70%.
7. bactericidal composition according to claim 1, is characterized in that with Silthiopham and metalaxyl for principle active component and insecticides adjuvant, excipients are mixed with any one formulation that agricultural chemicals allows.
8. bactericidal composition according to claim 7, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder or water dispersion granule.
9. the application of bactericidal composition according to claim 1 on preparation control fungal diseases of plants medicine.
10. application according to claim 9, is characterized in that described fungal diseases of plants is at least one in take-all, downy mildew, late blight.
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| EP1023832A1 (en) * | 1999-01-29 | 2000-08-02 | American Cyanamid Company | Aqueous suspension concentrate |
| CN103651472A (en) * | 2012-09-14 | 2014-03-26 | 陕西美邦农药有限公司 | Bactericidal composition containing penthiopyrad |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1023832A1 (en) * | 1999-01-29 | 2000-08-02 | American Cyanamid Company | Aqueous suspension concentrate |
| CN103651472A (en) * | 2012-09-14 | 2014-03-26 | 陕西美邦农药有限公司 | Bactericidal composition containing penthiopyrad |
| CN105145584A (en) * | 2012-09-14 | 2015-12-16 | 陕西美邦农药有限公司 | Sterilization composition containing penthiopyrad |
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