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CN105456538A - Drug for treating osteoporosis - Google Patents

Drug for treating osteoporosis Download PDF

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Publication number
CN105456538A
CN105456538A CN201510969130.0A CN201510969130A CN105456538A CN 105456538 A CN105456538 A CN 105456538A CN 201510969130 A CN201510969130 A CN 201510969130A CN 105456538 A CN105456538 A CN 105456538A
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parts
radix
drug
rhizoma
root
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刘增亮
毕妍娜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The invention relates to the field of pharmaceutical formulation, in particular to a drug for treating osteoporosis. The drug is characterized by being prepared from the following crude drugs in parts by weight: 5 to 9 parts of herba epimedii, 4 to 7 parts of aralia elata, 4 to 8 parts of lycopodium clavatum, 4 to 7 parts of uncaria rhynchophylla, 4 to 8 parts of radix dipsaci, 5 to 8 parts of root of Yunnan glorybower, 6 to 9 parts of woodfordia fruticosa, 6 to 9 parts of woodlouse, 7 to 9 parts of rhizoma drynariae, 6 to 9 parts of citrus chirocarpus, 2 to 5 parts of notopterygium root, 6 to 9 parts of trichosanthes palmata, 2 to 5 parts of the seed of Chinese dodder, 4 to 6 parts of root of sandhill tylophora, 2 to 4 parts of pine mushroom, 4 to 6 parts of asarum sieboldii, 2 to 4 parts of radices ligustici sinensis and 7 to 9 parts of semen boitae. The crude drugs are soaked by using water, and after decoction, the residuals are removed to obtain filter liquor. The drug provided by the invention has the efficacy of nourishing liver and kidney, and strengthening tendons and bones, traditional Chinese medicinal materials with different properties are adopted, and scientific combination is performed, so that an ideal curative effect can be realized, the drug can directly reach lesions, and is short in cure time, and the relapse is not liable to occur.

Description

Treat osteoporotic medicine
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically one treats osteoporotic medicine.
Background technology
As everyone knows, osteoporosis is the common a kind of bone metabolism disease of old people, and there is trend in advance at the current age, has become one of international public health problem.Its pathogenesis is always also very not clear and definite, and the change be commonly considered as because of factors such as hormone regulating and controlling (estrogen, parathyroid hormone, calcitonin and activated vitamin D), nutritional status (calcium, phosphorus, protein and fat etc.), physical factor (motion, daylight), immunologic function and heredity is closely related.Show human endocrine Developmental and Metabolic Disorder, the bone amount minimizing of skeleton, bone fine structure destroy, and bone biomechanical property declines, with the disease of bones quality and quantity.Osteoporotic site of pathological change is that human body axial bone and long bone of limbs are key, and maximum harm is fracture, and most common sympton is pain, common with lumbago and backache, accounts for 70%-80%.Osteoporotic fracture has a very long preclinical phase before occurring, period the most outstanding performance is exactly osteodynia, comprise back and extremities joint ache, weak etc., pain spreads along spinal column to both sides, pain relief when dorsal position or seat, stretch after upright or standing for a long time, sitting time the pain increased, pain relief in the daytime, night and early morning increase the weight of when waking up, and bend over, muscular movement, cough, stool increase the weight of when exerting oneself.
The Western medicine of current protect against osteoporosis mainly contains estrogen, calcitonin, diphosphate, Calcium and vitamin D class etc.Wherein estrogen is longer for medicine time, and may cause breast carcinoma and carcinoma of endometrium, prolonged application toxic and side effects is larger simultaneously.Calcitonin has certain curative effect to osteoporosis, but expensive, is difficult to for extensive patients accepts.
Summary of the invention
Object of the present invention is exactly to overcome existing technical deficiency, one is provided to treat osteoporotic medicine, there is nourishing the liver and kidney, effect of bone and muscle strengthening, adopts the Chinese crude drug of different properties, has carried out scientific compatibility, desirable therapeutic effect can be reached, the through focus of energy, healing time is short, not easily recurs after healing.
The technical scheme that the present invention solves the problems of the technologies described above employing is: one treats osteoporotic medicine, it is characterized in that being made up of the crude drug of following weight portion: Herba Epimedii 5 ~ 9, thorn fossilia dentis mastodi 4 ~ 7, Herba Lycopodii 4 ~ 8, Ramulus Uncariae Cum Uncis 4 ~ 7, Radix Dipsaci 4 ~ 8, Radix clerodendri yunnanensis 5 ~ 8, Flos Woodfordiae Fruticosae 6 ~ 9, Eupolyphaga Seu Steleophaga 6 ~ 9, Rhizoma Drynariae 7 ~ 9, Fructus Citri Sarcodactylis 6 ~ 9, Rhizoma Et Radix Notopterygii 2 ~ 5, Radix Stephaniae Cepharanthae 6 ~ 9, Semen Cuscutae 2 ~ 5, Radix Tylophorae arenicolae 4 ~ 6, armillaria Matsutake 2 ~ 4, Herba Asari 4 ~ 6, Rhizoma Ligustici 2 ~ 4, Semen Platycladi 7 ~ 9, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.
The invention has the beneficial effects as follows to have nourishing the liver and kidney, effect of bone and muscle strengthening, adopt the Chinese crude drug of different properties, carried out scientific compatibility, can reach desirable therapeutic effect, focus of going directly, healing time is short, not easily recurs after healing.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Herba Epimedii, thorn fossilia dentis mastodi, Herba Lycopodii, Ramulus Uncariae Cum Uncis, Radix Dipsaci, Radix clerodendri yunnanensis, Flos Woodfordiae Fruticosae, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Fructus Citri Sarcodactylis, Rhizoma Et Radix Notopterygii, Radix Stephaniae Cepharanthae, Semen Cuscutae, Radix Tylophorae arenicolae, armillaria Matsutake, Herba Asari, Rhizoma Ligustici, Semen Platycladi is adopted to be that raw material is prepared from.The every pair of its component (weight portion) is Herba Epimedii 7, thorn fossilia dentis mastodi 6, Herba Lycopodii 6, Ramulus Uncariae Cum Uncis 5, Radix Dipsaci 6, Radix clerodendri yunnanensis 6, Flos Woodfordiae Fruticosae 7, Eupolyphaga Seu Steleophaga 7, Rhizoma Drynariae 8, Fructus Citri Sarcodactylis 7, Rhizoma Et Radix Notopterygii 4, Radix Stephaniae Cepharanthae 8, Semen Cuscutae 3, Radix Tylophorae arenicolae 5, armillaria Matsutake 3, Herba Asari 5, Rhizoma Ligustici 3, Semen Platycladi 8.Get above-mentioned 18 taste raw materials, gross weight is 180 grams, add water 800 ~ 900 milliliters and at room temperature soak 5 ~ 6 hours, slow fire decocted to 60 ~ 80 minutes, filtrate about 150 milliliters of removing slag to obtain, and medicinal residues add water 200 ~ 300ml again, decoct 20 ~ 30 minutes, to remove slag to obtain filtrate 50 ~ 70 milliliters, altogether the medicine juice of about 200 ~ 220 milliliters, i.e. obtained decoction of the present invention.Load in sterile glass vials, seal bottle cap is for subsequent use, and every day 1 dose point 2 times is oral, sooner or later respectively once, and each (medicine) being taken before meal 100 ~ 110 milliliters.
Herba Epimedii of the present invention cures mainly impotence and premature ejaculation, pain in the low back and legs, numb limbs and tense tendons, promotes bone growth, prevention of osteoporosis; Ramulus Uncariae Cum Uncis has heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion effect; The vital energy benefiting and the kidney invigorating of thorn fossilia dentis mastodi, expelling wind and removing dampness, promoting blood circulation and stopping pain.The main deficiency of vital energy is weak, impotence due to deficiency of the kidney, rheumatoid bone bi-syndrome, weakness of the waist and knees, traumatic injury, fracture; Herba Lycopodii relaxing muscles and tendons to promote blood circulation, invigorating qi and dredging collateral reducing swelling and alleviating pain, controls traumatic injury; Radix Dipsaci tonifying liver, bone and muscle strengthening, determines meridians, and only in warp, (muscles and bones) is ached; Radix clerodendri yunnanensis expelling wind and activating blood circulation, detumescence, blood pressure lowering.Treating rheumatic arthritis, lumbago and skelalgia; Flos Woodfordiae Fruticosae is restrained, and controls dysentery, menoxenia, hemorrhoid; Eupolyphaga Seu Steleophaga has removing blood stasis, effect of reunion of fractured tendons and bones.For traumatic injury, the injury of tendon and muscle is fractured, blood stasis amenorrhea, and postpartum stagnation is suffered from abdominal pain, addiction abdominal mass mass in the abdomen; Rhizoma Drynariae the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; Fructus Citri Sarcodactylis has activating QI to eliminate phlegm, the multiple medicinal functions such as cough-relieving relieving distension, the liver soothing and the spleen invigorating stomach function regulating; Rhizoma Et Radix Notopterygii fall apart exterior cold wind-damp dispelling profit joint.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; Radix Stephaniae Cepharanthae heat-clearing and toxic substances removing, cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.For acute hepatitis, bacillary dysentery, internal hemorrhage, traumatic injury; Semen Cuscutae cures mainly lumbago tinnitus, and impotence and seminal emission is quenched one's thirst, sterile, enuresis incontinence, stranguria with turbid discharge leukorrhagia, and the head is dim; Radix Tylophorae arenicolae enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood; Armillaria Matsutake relaxing muscles and tendons and activating QI and blood in the collateral activating QI to eliminate phlegm dampness removing is not turbid.Main lumbago and skelalgia numb hand and foot grain does not relax; Herba Asari induces sweat cold expelling, and wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention; Rhizoma Ligustici is used for exterior syndrome due to wind-cold, top, mountain peak pain, rheumatic arthralgia; Semen Platycladi has tranquilizing by nourishing the heart, loosening bowel to relieve constipation, effect of hidroschesis.For deficiency of YIN-blood, fidgets due to deficiency is had a sleepless night, severe palpitation, dryness of the intestine constipation, night sweat due to yin deficiency.
The each raw material of the present invention also can the embodiment that mixes of ratio (weight portion) listed by according to the form below realize.Its processing technique is identical with embodiment 1.
The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:
Diagnostic criteria is with reference to " diagnostic criteria of primary osteoporosis for Chinese people (trying) ", according to international diagnostic criteria, simultaneously in conjunction with Chinese feature, according to bone density lower than agnate, same to sex, deduct two standard deviations (-2.0SD) with position Healthy People peak bone mass bone amount meansigma methods, osteoporosis can be diagnosed as.
Treatment group: take embodiment one medicament, every day 1 dose point 2 times is oral, sooner or later each once, each (medicine) being taken before meal 100 ~ 110 milliliters 1 month is a course for the treatment of.
Matched group: oral alfacalcidol soft capsule 0.5 μ g (2), 1 time on the one; Oral calcium gluconate oral administration solution one time 1,3 times on the one; Oral clodronic acid disodium, 1.6g/ day, takes at twice, entering diet front and rear 2 hours, takes between meal, within 1 month, is a course for the treatment of.
Osteoporosis efficacy assessment standard:
The observation of clinical cardinal symptom is with reference to Chinese's osteoporosis suggestion diagnostic criteria.
Effective: lumbar and back pain disappears substantially, functional activity is normal.
Effective: lumbar and back pain alleviates, functional activity is normal.
Invalid: lumbar and back pain does not alleviate, functional activity does not improve
Therapeutic outcome:
See table 1, as can be seen from Table 1, adopt treatment by Chinese herbs osteoporosis of the present invention, relative to matched group on therapeutic effect, there is significant improvement.
A table 1 liang group treats Clinical efficacy comparison example (%) after 2 months respectively
Group Number of cases Effective Effectively Invalid Total effective rate
Treatment group 50 43 6 1 98％
Matched group 50 38 7 5 90％
Model case: patient Hu, female, 61 years old, because lumbago is gone to a doctor, forgetful, tongue is thin, thready pulse without strength, with alopecia tooth pine, Hiccough and deaf, soreness of the waist and knees, through health check-up and kidney function test no abnormality seen, x-ray inspection shows: tubular bone cortex is thinning, pulp cavity broadens, bone trabecula decreased number, its gap is also broadening, is diagnosed as osteoporosis.Take embodiment one medicament, every day 1 dose point 2 times is oral, sooner or later each once, each (medicine) being taken before meal 100 ~ 110 milliliters, treat lumbar and back pain after 1 month and alleviate, functional activity is normal, and treat lumbar and back pain after 2 months and substantially disappear, functional activity is normal.

Claims (1)

1. the osteoporotic medicine for the treatment of, it is characterized in that being made up of the crude drug of following weight portion: Herba Epimedii 5 ~ 9, thorn fossilia dentis mastodi 4 ~ 7, Herba Lycopodii 4 ~ 8, Ramulus Uncariae Cum Uncis 4 ~ 7, Radix Dipsaci 4 ~ 8, Radix clerodendri yunnanensis 5 ~ 8, Flos Woodfordiae Fruticosae 6 ~ 9, Eupolyphaga Seu Steleophaga 6 ~ 9, Rhizoma Drynariae 7 ~ 9, Fructus Citri Sarcodactylis 6 ~ 9, Rhizoma Et Radix Notopterygii 2 ~ 5, Radix Stephaniae Cepharanthae 6 ~ 9, Semen Cuscutae 2 ~ 5, Radix Tylophorae arenicolae 4 ~ 6, armillaria Matsutake 2 ~ 4, Herba Asari 4 ~ 6, Rhizoma Ligustici 2 ~ 4, Semen Platycladi 7 ~ 9, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.
CN201510969130.0A 2015-12-14 2015-12-14 Drug for treating osteoporosis Pending CN105456538A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107349363A (en) * 2017-07-14 2017-11-17 庄乾东 A kind of Chinese medicine preparation for treating osteoporosis and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437984A (en) * 2003-01-27 2003-08-27 鲁南制药股份有限公司 Medicine for treating osteoporosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437984A (en) * 2003-01-27 2003-08-27 鲁南制药股份有限公司 Medicine for treating osteoporosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107349363A (en) * 2017-07-14 2017-11-17 庄乾东 A kind of Chinese medicine preparation for treating osteoporosis and preparation method thereof

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