CN105435366A - Implanted neural adjustment and control system - Google Patents
Implanted neural adjustment and control system Download PDFInfo
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- CN105435366A CN105435366A CN201510970895.6A CN201510970895A CN105435366A CN 105435366 A CN105435366 A CN 105435366A CN 201510970895 A CN201510970895 A CN 201510970895A CN 105435366 A CN105435366 A CN 105435366A
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- 230000001537 neural effect Effects 0.000 title abstract description 9
- 238000011282 treatment Methods 0.000 claims abstract description 24
- 238000001467 acupuncture Methods 0.000 claims abstract description 23
- 238000007920 subcutaneous administration Methods 0.000 claims abstract description 17
- 210000005036 nerve Anatomy 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 12
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000008589 Obesity Diseases 0.000 claims abstract description 6
- 235000020824 obesity Nutrition 0.000 claims abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 5
- 238000002513 implantation Methods 0.000 claims abstract description 3
- 239000000523 sample Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 230000007661 gastrointestinal function Effects 0.000 claims description 4
- 210000001178 neural stem cell Anatomy 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000007383 nerve stimulation Effects 0.000 abstract description 3
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000007794 irritation Effects 0.000 description 5
- 230000004007 neuromodulation Effects 0.000 description 5
- 230000005611 electricity Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000008035 Back Pain Diseases 0.000 description 2
- 208000014540 Functional gastrointestinal disease Diseases 0.000 description 2
- 208000016097 disease of metabolism Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000003195 fascia Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000034347 Faecal incontinence Diseases 0.000 description 1
- 206010052105 Gastrointestinal hypomotility Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 201000005081 Intestinal Pseudo-Obstruction Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 208000019804 backache Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
- 239000003629 gastrointestinal hormone Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 210000001617 median nerve Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 210000004345 peroneal nerve Anatomy 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0504—Subcutaneous electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/002—Using electric currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0507—Electrodes for the digestive system
- A61N1/0509—Stomach and intestinal electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
- A61N1/36085—Eating disorders or obesity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/02—Radiation therapy using microwaves
- A61N5/022—Apparatus adapted for a specific treatment
- A61N5/025—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2205/00—Devices for specific parts of the body
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- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Rehabilitation Therapy (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Obesity (AREA)
- Developmental Disabilities (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Finger-Pressure Massage (AREA)
Abstract
The invention discloses an implanted neural adjustment and control system. The implanted neural adjustment and control system is used for the treatment of gastrointestinal tract functional diseases, obesity and diabetes. The implanted neural adjustment and control system includes electrodes which are buried at specific subcutaneous acupoints and a stimulator; the electrodes include one or more needle-shaped electrodes; the electrodes are arranged at preset acupuncture and moxibustion points through subcutaneous implantation; and the electrodes are connected with the stimulator, so that electric waves can be passed to stimulate a body tissue. The implanted neural adjustment and control system of the invention has a nerve stimulation or nerve adjustment and control function. With the implanted neural adjustment and control system adopted, traditional acupuncture can be fundamentally improved. According to the implanted neural adjustment and control system, the electrodes are buried under skin chronically through using a minimally invasive technique, and are connected with the stimulator, and stimulation parameters can be adjusted specifically, and the situation that the electro-acupuncture therapy parameters are unknown can be changed; the treatment course of a patient can be extended to a daily course, and treatment can be carried out by two times to three times per day, and the patient can be treated at home, so that the patient does not need to go to a hospital and a clinic, and great conveniences can be provided.
Description
Technical field
The present invention relates to a kind of neuromodulation system based on subcutaneous implant electrode, specifically a kind of implantable nerve regulator control system.
Background technology
Acupuncture or acusector are used for the treatment of anxiety neurosis for a long time always, lumbago and backache, hypertension and osteoarthritis.Current medical domain, acupuncture is used for the treatment of gastrointestinal function disease and obesity by people more and more.Traditional acupuncture be fine needle is thrust subcutaneous specific acupuncture point by body surface and in addition maneuver to treat relevant disease.Acusector is one of method of acupuncture and moxibustion therapy, and it is electricity irritation in addition on traditional acupuncture.Clinically, the parameter of electroacupuncture stimulation is very fuzzy, and doctor depends primarily on the Bearing degree of patient, lacks uniformity.More importantly, the treatment of traditional acupuncture or acusector is temporary, treatments period patient usually go weekly hospital or clinic 2-3 time even less, treatment has just been interrupted at every turn after leaving doctor, and go hospital or clinic treatment to affect the daily life of working clan patient, these all hamper therapeutic effect.
Summary of the invention
The object of the present invention is to provide a kind of implantable nerve regulator control system, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of implantable nerve regulator control system, for the treatment of gastrointestinal function disease, obesity and diabetes, comprise the electrode and stimulator that are embedded in subcutaneous particular acupoint, electrode is made up of one or more pin sample shape electrode, electrode is imbedded at through subcutaneous the acupoint preset, Electrode connection stimulator, transmits electric wave to stimulate bodily tissue.
As the further scheme of the present invention: described electrode is by wired or wireless connection stimulator.
As the present invention's further scheme: described stimulator is external pulse generator.
As the present invention's further scheme: described stimulator is an external instrument, the electrode implanted is stimulated by remote microwave wireless transmit, stimulator comprises an implantation type wireless accepter, and radio receiver receives the signal being placed in the radio transmitter outside subject and sending.
As the present invention's further scheme: described stimulator is stimulated by Neural stem cell or microwave thermal, Neural stem cell is by embedding probe in vivo or realized by external magnetic field direct effect, the microwave that external instrument produces or magnetic field heating imbedded electrode thus produce thermostimulation to acupuncture point surrounding body tissue.
Compared with prior art, the invention has the beneficial effects as follows: the effect with nerve stimulation or neuromodulation, fundamentally improve traditional acupuncture, by less invasive techniques, electrode " chronic " is embedded in subcutaneous and connects small-sized stimulator, stimulus parameter can specifically regulate, and changes the present situation that current electronic acupuncture and moxibustion therapeutic parameter is not clear; The treatment easily extensible course for the treatment of of patient is carry out every day, 2-3 time on the one, and patient can be in treatment voluntarily, avoids hospital clinic of hurrying back and forth, provides great convenience.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
In the embodiment of the present invention, a kind of implantable nerve regulator control system, for the treatment of gastrointestinal function disease, obesity and diabetes, comprise the electrode and stimulator that are embedded in subcutaneous particular acupoint, electrode is made up of one or more pin sample shape electrode, electrode is imbedded at through subcutaneous the acupoint preset, by wired or wireless connection stimulator thus transmit electric wave to stimulate bodily tissue, subcutaneous acupoint stimulation or the regulation and control of title underlying nerve can promote that human body discharges some specific gastrointestinal hormone, thus are conducive to the treatment of relevant disease.Described stimulator is external pulse generator.
Electrode will be permanently embedded in subcutaneous chronically, describedly chronicly refer to that electrode will be stored in subcutaneous a couple of days, several weeks or several months, describedly permanently refer to that required treatment time will electrode will be saved more than 1 year more than 1 year, the embedding of electrode depends on specific acupuncture point or meridians, and foundation institute controls disease and determines, embedding position will in subcutaneous, under for example electrode is placed in skin corium and epidermal area, in subcutaneous tissue, or electrode will be positioned on fascia or under fascia, specifically depending on controlled disease, in addition, if muscular irritation is needed for treatment preferentially, so electrode will be embedded in belly of muscle place, as previous elaboration, the distribution of human acupoint moves towards very consistent with nerve, therefore, electrode buries the position of putting can fix on specific nerve containing a certain acupuncture point or meridians or plexus nervorum, in some cases, it will be 1 that electrode buries the degree of depth of putting, 2, 3, 4, 5, 6, 7, 8, 9 or 10 millimeters are not etc., depending on acupuncture point.
The neuromodulation system related in patent of the present invention will be relevant to disease specific.The system for the treatment of metabolic disease will be made up of following; Electrode is embedded in as tsu san li near acupuncture point, Liangmen, Tianshu, the middle part of gastric cavity and/or close first, and electrode is connected with embedded type signal generator and then produces the signal of telecommunication; Metabolic disease comprises diabetes or obesity, and electricity irritation will reduce patient's level of postprandial blood sugar and/or increase insulin sensitivity; Some application will be used for the treatment of functional gastrointestinal disease, and this system comprises: imbedded electrode is positioned at tsu san li, Liangmen, Tianshu, the middle part of gastric cavity and/or close unit, and electrode is connected with embedded type signal generator and then produces the signal of telecommunication; Functional gastrointestinal disease comprises esophageal reflux disease, functional dyspepsia, chronic small intestinal pseudo-obstruction, and diarrhoea, constipation, irritable bowel syndrome or fecal incontinence, in some cases, special acupuncture point is tsu san li and/or interior pass.
The electric wire of electrode will pass through from subcutaneous and be connected with stimulated in vitro device.Stimulated in vitro device by being embedded in the subcutaneous suitable position of human body chronically, as abdominal part.In some cases, stimulator can be embedded in acupuncture point place.Electricity irritation uses onboard clock and program by electrode, or uses external switching device, such as magnetic switch.Electricity irritation can be one pole, will as other end electrode at this situation embedded type pulse generator; Also can be bipolar, two electrodes are placed in Different Acupoint thus form loop in the case.If use multiple electrode in Different Acupoint, patent of the present invention also can use multichannel to stimulate.Stimulus parameter will need depending on disease specific treatment, and permission is adjusted all kinds of parameter by this neural regulator control system, as ripple is wide, and stimulation time, stimulus intensity, like this.
Stimulated in vitro utensil in patent of the present invention has the function be coupled with imbedded electrode by the boost pulse that self produces, thus electric current is passed to acupuncture point.In addition, stimulated in vitro device also can produce magnetic field or microwave signal and be sent to embedding stimulating electrode.Then heating electrode is transmitted thermostimulation to uniform temperature by microwave or magnetic field.
Patent of the present invention fundamentally improves traditional acupuncture, by less invasive techniques, electrode " chronic " is embedded in subcutaneous and connects small-sized stimulator, stimulus parameter can specifically regulate, change the present situation that current electronic acupuncture and moxibustion therapeutic parameter is not clear, use patent of the present invention, the treatment easily extensible course for the treatment of of patient is carry out every day, 2-3 time on the one, patient can be in treatment voluntarily, avoids hospital clinic of hurrying back and forth, provides great convenience.
The present invention is called the theoretical foundation that " neuromodulation " has it, about 361 acupoints are positioned at each passages through which vital energy circulates of whole body altogether, these passages through which vital energy circulates are understood from anatomy, associate specific internal organs or other position of health, research shows, the distribution of acupoint is neural out of shape consistent with health, and such as important cave tsu san li is positioned on deep peroneal nerve, and interior pass is positioned on median nerve.Therefore according to the degree of depth of imbedded electrode, patent of the present invention has the effect of nerve stimulation or neuromodulation.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. an implantable nerve regulator control system, it is characterized in that, for the treatment of gastrointestinal function disease, obesity and diabetes, comprise the electrode and stimulator that are embedded in subcutaneous particular acupoint, electrode is made up of one or more pin sample shape electrode, electrode is imbedded at through subcutaneous the acupoint preset, Electrode connection stimulator, transmits electric wave to stimulate bodily tissue.
2. implantable nerve regulator control system according to claim 1, is characterized in that, described electrode is by wired or wireless connection stimulator.
3. implantable nerve regulator control system according to claim 1 and 2, is characterized in that, described stimulator is external pulse generator.
4. implantable nerve regulator control system according to claim 1, it is characterized in that, described stimulator is an external instrument, the electrode implanted is stimulated by remote microwave wireless transmit, stimulator comprises an implantation type wireless accepter, and radio receiver receives the signal being placed in the radio transmitter outside subject and sending.
5. implantable nerve regulator control system according to claim 1, it is characterized in that, it is characterized in that, described stimulator is stimulated by Neural stem cell or microwave thermal, Neural stem cell is by embedding probe in vivo or realized by external magnetic field direct effect, the microwave that external instrument produces or magnetic field heating imbedded electrode thus produce thermostimulation to acupuncture point surrounding body tissue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510970895.6A CN105435366A (en) | 2015-12-21 | 2015-12-21 | Implanted neural adjustment and control system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510970895.6A CN105435366A (en) | 2015-12-21 | 2015-12-21 | Implanted neural adjustment and control system |
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| CN105435366A true CN105435366A (en) | 2016-03-30 |
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| CN201510970895.6A Pending CN105435366A (en) | 2015-12-21 | 2015-12-21 | Implanted neural adjustment and control system |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030078642A1 (en) * | 1999-12-09 | 2003-04-24 | James Malaney | Implantable electro-acupuncture device |
| CN1745857A (en) * | 2005-10-28 | 2006-03-15 | 清华大学 | An implantable electrical nerve impulse stimulation system |
| CN1876200A (en) * | 2006-07-07 | 2006-12-13 | 清华大学 | Implant type electronic acupuncture and moxibustion therapeutic device |
| CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
-
2015
- 2015-12-21 CN CN201510970895.6A patent/CN105435366A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030078642A1 (en) * | 1999-12-09 | 2003-04-24 | James Malaney | Implantable electro-acupuncture device |
| CN1745857A (en) * | 2005-10-28 | 2006-03-15 | 清华大学 | An implantable electrical nerve impulse stimulation system |
| CN1876200A (en) * | 2006-07-07 | 2006-12-13 | 清华大学 | Implant type electronic acupuncture and moxibustion therapeutic device |
| CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
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Effective date of registration: 20170705 Address after: 05, 210000 floor, Metro technology building, 69 Olympic Sports Avenue, Jianye District, Jiangsu, Nanjing Applicant after: Nanjing Shi Dewei Medical Technology Co Ltd Address before: 1, 315800 building, No. 491, West West Road, Beilun District, Zhejiang, Ningbo province -23 Applicant before: NINGBO BETH TRANSLATIONAL MEDICINE RESEARCH CENTER CO., LTD. |
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Application publication date: 20160330 |