CN105434529A - Radix scutellariae-rhizoma atractylodis macrocephalae cataplasm used for treating primary dysmenorrheal, and preparation method thereof - Google Patents
Radix scutellariae-rhizoma atractylodis macrocephalae cataplasm used for treating primary dysmenorrheal, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a radix scutellariae-rhizoma atractylodis macrocephalae cataplasm used for treating primary dysmenorrheal, and a preparation method thereof. The radix scutellariae-rhizoma atractylodis macrocephalae cataplasm comprises an anti-sticking layer, a drug-containing unguent body, and a back layer; the drug-containing unguent body is prepared from radix scutellariae extract, rhizoma atractylodis macrocephalae extract, and appropriate amounts of pharmaceutic adjuvants such as a cross-linking agent, a binding agent, an antioxidant, a pH adjusting agent; wherein the crude drug ratio of the radix scutellariae extract and the rhizoma atractylodis macrocephalae extract is controlled to be 1:1, and the radix scutellariae extract and the rhizoma atractylodis macrocephalae extract are obtained via supercritical CO2 extraction under 30 to 40MPa at 25 to 35 DEG C. Active component extraction ratio of the preparation method is high; medicinal material utilization ratio is high; application of organic solvent is avoided; the prepared radix scutellariae-rhizoma atractylodis macrocephalae cataplasm is high in drug loading capacity, excellent in stability, high in transdermal absorption ratio, excellent in curative effect, possesses no sensitization or irritation, and excellent patient compliance.
Description
Technical field
The present invention relates to a kind of Chinese medicine for external application, particularly a kind of a kind of reed mentioned in ancient books art cataplasma for the treatment of primary dysmenorrhea and preparation method thereof, belongs to medical art.
Background technology
Dysmenorrhea is one of large difficult disease of TCM Gynecology three, and the cause of disease is complicated, and treat thorny, it is an independently disease, and be again many gynopathic syndromes, its sickness rate is 30% ~ 80%.The traditional Chinese medical science think dysmenorrhea because of not outer feelings will hinder, daily life accidentally or six climate exopathogens cause harm, due to collaterals of the uterus QI and blood change before and after menstrual period sharply, be subject to pathological factor interference and occur the large class disease of deficiency and excess two.Modern medicine thinks that dysmenorrhea is because uterine contraction strengthens, and uterine blood flow reduces and causes uterus ischemia, thinks that dysmenorrhea is also relevant with the factor such as endocrine, the mental status, heredity simultaneously.
At present, clinical treatment dysmenorrhea can adopt Western medicine and Chinese medicine two kinds of modes, and Western medicine then adopts the hormone medicine ovulation inhibitions such as Injection of Megestrol Acetate sheet and suppresses inner membrance growth, weakens uterus activity and reaches therapeutic purposes, western medicine scheme is taken stopgap measures non-effecting a permanent cure, and there is the drawback of larger side effect; Chinese medicine then carries out corresponding compatibility according to disease, can reach the object for the treatment of both the principal and secondary aspects of a disease, and within several thousand, wide clinical application have accumulated abundant medication experience.
Academic dissertation " study of pharmacy of a kind of reed mentioned in ancient books art dysmenorrhea patch "; within 2009, disclose a kind of preparation method of a kind of reed mentioned in ancient books art cataplasma, after gelatin is fully swelling in suitable quantity of water, add 1% sodium polyacrylate, PVP K-30, glycerol and extractum; mixing; in 50 DEG C ~ 60 DEG C water-baths, heating makes melting, is slowly stirred to evenly, coats on non-woven fabrics backing while hot; thickness is about 0.5mm; place ripening, cover protecting film, put sealing in sealed bag and preserve.Wherein the mass ratio of 1% sodium polyacrylate, PVP K-30, gelatin, glycerol is 4:4:3:4, extractum is weight is the Radix Scutellariae of 1:1 and the dry gained of 70% ethanol percolation extract of the Rhizoma Atractylodis Macrocephalae 15 times amount, wherein the flow velocity of seepage pressure effects is 15mL/minKg, in cataplasma extractum weight be 1% sodium polyacrylate, PVP K-30, gelatin, glycerol four kinds of materials gross weight 25%.Prepared a kind of reed mentioned in ancient books art cataplasma has the advantage that release is fast and transdermal absorption factor is high.
But above-mentioned prior art also exists obvious shortcomings and deficiencies: one is that employing 70% ethanol percolate extraction prepared by extractum, extraction efficiency is low and extraction is incomplete; Two are flavones ingredients such as main active wogonin, baicalin in preparation is faintly acid, and part flavonoid active component is ionized into ionic condition, is difficult to Transdermal absorption; Three is lack antioxidant in formula, cannot overcome Rhizoma Atractylodis Macrocephalae volatile oil oxidative deformation.
Summary of the invention
The invention provides a kind of reed mentioned in ancient books art cataplasma of a kind of novel treatment primary dysmenorrhea and preparation method thereof, this preparation method extracts Radix Scutellariae and Rhizoma Atractylodis Macrocephalae active component is complete and efficiency is high, a kind of reed mentioned in ancient books art cataplasma Transdermal absorption utilizing the method to prepare is good, pain palliation efficacy is good, and stability is high, Rhizoma Atractylodis Macrocephalae volatile oil oxidation stain can be avoided.
Technical scheme of the present invention is: a kind of a kind of reed mentioned in ancient books art cataplasma for the treatment of primary dysmenorrhea, comprise ointment-containing body, described ointment-containing body is made up of Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract and pharmaceutic adjuvant, a kind of reed mentioned in ancient books art cataplasma ointment-containing body is become by following components in mass portion array: Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract 20 ~ 100 parts are (with Radix Scutellariae, Rhizoma Atractylodis Macrocephalae crude drug gauge), sodium sulfite 0.05 ~ 0.5 part, ethylenediaminetetraacetic acid, 0.08 ~ 0.8 part, citric acid 0.1 ~ 5 part, carbomer 1 ~ 10 part, sodium polyacrylate NP7002 ~ 8 part, glycerol 5 ~ 35 parts, Kaolin 1 ~ 5 part, dihydroxyaluminum aminoacetate 0.5 ~ 2 part, sorbitol 1 ~ 5 part, titanium dioxide 0.1 ~ 4 part, deionized water 30 ~ 70 parts, described Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract are obtained by following methods: crude drug amount is that the Radix Scutellariae of 1:1 and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 30 ~ 40MPa extracting pressure and 25 ~ 35 DEG C of temperature, extract is evaporated to thick paste, the content of dispersion often pasting a kind of reed mentioned in ancient books art cataplasma is the crude drug amount of 5 ~ 10 grams of Radix Scutellariaes and the Rhizoma Atractylodis Macrocephalae.Ointment-containing body preferred ingredient is Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract 80 parts (with Radix Scutellariae, Rhizoma Atractylodis Macrocephalae crude drug gauge), sodium sulfite 0.2 part, ethylenediaminetetraacetic acid 0.4 part, citric acid 3 parts, carbomer 6 parts, sodium polyacrylate NP7005 part, glycerol 20 parts, Kaolin 3 parts, dihydroxyaluminum aminoacetate 1.5 parts, sorbitol 3 parts, titanium dioxide 2 parts, deionized water 50 parts.
Treat a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea, the pH value of the ointment-containing body of described a kind of reed mentioned in ancient books art cataplasma is 4.5 ~ 6, and the ionization of active component wogonin, baicalin can be avoided or reduce to faintly acid, makes active component molecularly state, is conducive to Transdermal absorption.
Treat a preparation method for a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea, described preparation method comprises the following steps:
(1) take Radix Scutellariae 10 ~ 50 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 50 parts by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 30 ~ 40MPa extracting pressure and 25 ~ 35 DEG C of temperature, and extract is evaporated to thick paste;
(2) thick paste prepared by step (1) is dissolved in 30 ~ 70 parts of deionized waters, mix homogeneously;
(3) in step (2), sodium sulfite 0.05 ~ 0.5 part, ethylenediaminetetraacetic acid 0.08 ~ 0.8 part, citric acid 0.1 ~ 5 part, carbomer 1 ~ 10 part is added, mix homogeneously;
(4) taking sodium polyacrylate NP7002 ~ 8 part is by weight dissolved in 5 ~ 35 parts of glycerol;
(5) Kaolin 1 ~ 5 part, dihydroxyaluminum aminoacetate 0.5 ~ 2 part, sorbitol 1 ~ 5 part, titanium dioxide 0.1 ~ 4 part is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) joined in compositions prepared by step (3), place ripening 24h, coat on backing layer non-woven fabrics, add adherent layer lid polyethylene film, lucifuge ventilation is dried naturally, to obtain final product.
Treat a preparation method for a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea, the preferred extraction conditions of supercritical carbon dioxide extraction is pressure 35MPa, temperature 30 DEG C.
Treat a preparation method for a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea, extract is evaporated to thick paste, and the relative density of described thick paste is 1.0 ~ 1.1g/mL.
A kind of reed mentioned in ancient books art cataplasma ointment-containing body that the present invention treats primary dysmenorrhea is prepared from by Radix Scutellariae and the pharmaceutic adjuvant such as Rhizoma Atractylodis Macrocephalae supercritical carbon dioxide extraction thing and adhesive, wetting agent, cross-linking agent, filler, antioxidant, pH adjusting agent, prepared ointment-containing body and adherent layer, backing layer are prepared into complete a kind of reed mentioned in ancient books art cataplasma, a kind of reed mentioned in ancient books art cataplasma prepared by the present invention has that drug loading is large, good stability, transdermal absorption factor are high, good effect, without sensitization and irritating advantage, patient compliance is good.
Beneficial effect of the present invention is:
1, the present invention uses supercritical extraction to prepare Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract, and one is the content that improve active component wogonin, baicalin in extract, and extraction efficiency is high, and medical material utilization rate is high, and extract impurity is few; Two is avoid using the organic solvent extraction such as ethanol, and avoiding organic solvent residual causes skin irritation; Three is supercritical extraction energy-conserving and environment-protective, discharges without debirs.
2, the acidic materials such as sodium sulfite, citric acid are contained in cataplasma formula of the present invention, the ionization of the flavones ingredients such as main active wogonin, baicalin in Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract can be suppressed, promote the acid ingredient such as wogonin, baicalin Transdermal absorption.
3, contain antioxidant sodium sulfite in cataplasma formula of the present invention, to alleviate or to overcome the oxidative deformation of composition in Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract, ensure quality and the stability of preparation.
Detailed description of the invention
Can better understand the present invention for making those skilled in the art and can be implemented, below in conjunction with specific embodiment, the present invention is further elaborated.
One, embodiment of the present invention part
Embodiment 1
(1) Radix Scutellariae 10g, Rhizoma Atractylodis Macrocephalae 10g is taken by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 40MPa extracting pressure and 25 DEG C of temperature, extraction time is 2-3h (the preferred 3h of the present embodiment), extract is evaporated to thick paste, and thick paste relative density is 1.0g/mL (with density 1.0g/mL water for reference);
(2) thick paste prepared by step (1) is dissolved in 50g deionized water, mix homogeneously;
(3) in step (2), sodium sulfite 0.05g, ethylenediaminetetraacetic acid 0.2g, citric acid 2g, carbomer 4g is added, mix homogeneously;
(4) taking sodium polyacrylate NP7004g is by weight dissolved in 10g glycerol, and sodium polyacrylate NP700 is the sodium polyacrylate product that Japanese Showa company produces;
(5) Kaolin 1g, dihydroxyaluminum aminoacetate 1.5g, sorbitol 2g, titanium dioxide 1g is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) is joined in compositions prepared by step (3), after mix homogeneously, mastic pH value is 4.5 ~ 6 (the preferred pH=5.5 of the present embodiment), place ripening 18-24h (the preferred 24h of the present embodiment), coat on backing layer non-woven fabrics, add a cover adherent layer polyethylene film, lucifuge ventilation is dried naturally, obtains 4 subsides a kind of reed mentioned in ancient books art cataplasmas.
Embodiment 2
(1) take Radix Scutellariae 30g, Rhizoma Atractylodis Macrocephalae 30g by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 35MPa extracting pressure and 30 DEG C of temperature, and extraction time is 2h, and extract is evaporated to thick paste, and thick paste relative density is 1.05g/mL;
(2) thick paste prepared by step (1) is dissolved in 70g deionized water, mix homogeneously;
(3) in step (2), sodium sulfite 0.2g, ethylenediaminetetraacetic acid 0.8g, citric acid 0.1g, carbomer 6g is added, mix homogeneously;
(4) taking sodium polyacrylate NP7008g is by weight dissolved in 35g glycerol;
(5) Kaolin 5g, dihydroxyaluminum aminoacetate 1g, sorbitol 5g, titanium dioxide 1.5g is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) is joined in compositions prepared by step (3), after mix homogeneously, mastic pH value is 6, place ripening 20h, coat on backing layer non-woven fabrics, add a cover adherent layer polyethylene film, lucifuge ventilation is dried naturally, obtains 6 subsides a kind of reed mentioned in ancient books art cataplasmas.
Embodiment 3
(1) take Radix Scutellariae 50g, Rhizoma Atractylodis Macrocephalae 50g by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 35MPa extracting pressure and 35 DEG C of temperature, and extraction time is 2.5h, and extract is evaporated to thick paste, and thick paste relative density is 1.1g/mL;
(2) thick paste prepared by step (1) is dissolved in 30g deionized water, mix homogeneously;
(3) in step (2), sodium sulfite 0.5g, ethylenediaminetetraacetic acid 0.3g, citric acid 1g, carbomer 10g is added, mix homogeneously;
(4) taking sodium polyacrylate NP7005g is by weight dissolved in 25g glycerol;
(5) Kaolin 2g, dihydroxyaluminum aminoacetate 0.5g, sorbitol 3g, titanium dioxide 4g is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) is joined in compositions prepared by step (3), after mix homogeneously, mastic pH value is 5, place ripening 18h, coat on backing layer non-woven fabrics, add a cover adherent layer polyethylene film, lucifuge ventilation is dried naturally, obtains 10 subsides a kind of reed mentioned in ancient books art cataplasmas.
Embodiment 4
(1) take Radix Scutellariae 40g, Rhizoma Atractylodis Macrocephalae 40g by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 30MPa extracting pressure and 25 DEG C of temperature, and extraction time is 2h, and extract is evaporated to thick paste, and thick paste relative density is 1.06g/mL;
(2) thick paste prepared by step (1) is dissolved in 45g deionized water, mix homogeneously;
(3) in step (2), sodium sulfite 0.1g, ethylenediaminetetraacetic acid 0.08g, citric acid 5g, carbomer 1g is added, mix homogeneously;
(4) taking sodium polyacrylate NP7002g is by weight dissolved in 5g glycerol;
(5) Kaolin 2.5g, dihydroxyaluminum aminoacetate 2g, sorbitol 1g, titanium dioxide 0.1g is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) is joined in compositions prepared by step (3), after mix homogeneously, mastic pH value is 4.5, place ripening 20h, coat on backing layer non-woven fabrics, add a cover adherent layer polyethylene film, lucifuge ventilation is dried naturally, obtains 16 subsides a kind of reed mentioned in ancient books art cataplasmas.
Embodiment 5
(1) take Radix Scutellariae 40g, Rhizoma Atractylodis Macrocephalae 40g by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 30MPa extracting pressure and 30 DEG C of temperature, and extraction time is 3h, and extract is evaporated to thick paste, and thick paste relative density is 1.08g/mL;
(2) thick paste prepared by step (1) is dissolved in 50g deionized water, mix homogeneously;
(3) in step (2), sodium sulfite 0.2g, ethylenediaminetetraacetic acid 0.4g, citric acid 3g, carbomer 6g is added, mix homogeneously;
(4) taking sodium polyacrylate NP7005g is by weight dissolved in 20g glycerol;
(5) Kaolin 3g, dihydroxyaluminum aminoacetate 1.5g, sorbitol 3g, titanium dioxide 2g is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) is joined in compositions prepared by step (3), after mix homogeneously, mastic pH value is 5, place ripening 24h, coat on backing layer non-woven fabrics, add a cover adherent layer polyethylene film, lucifuge ventilation is dried naturally, obtains 10 subsides a kind of reed mentioned in ancient books art cataplasmas.
Two, comparative example's part
Comparative example 1 Radix Scutellariae and Rhizoma Atractylodis Macrocephalae alcohol reflux
Take Radix Scutellariae 40g, Rhizoma Atractylodis Macrocephalae 40g by weight, add 8 times amount 70% alcohol reflux 2 times, extract 1.5h, extract drying under reduced pressure obtains extractum at every turn.
Three, experimental sections
Experimental example 1 supercritical carbon dioxide extraction thing compares with alcohol reflux thing
Adopt high performance liquid chromatography to measure the content of baicalin and wogonin in embodiment 1 ~ 5 supercritical carbon dioxide extraction thing and comparative example 1 alcohol reflux thing respectively, to evaluate the rate of transform of 2 kinds of different extraction process active component, the results are shown in Table 1.
Table 1 embodiment 1 ~ 5 and comparative example 1 active component rate of transform result
In embodiment 1 ~ 5 wogonin extract the rate of transform for 44.7% ~ 47.1%, to extract the rate of transform be 55.1% ~ 58.2% to baicalin; And comparative example 1 wogonin extracts, and the rate of transform is 36.5%, the baicalin extraction rate of transform is 42.7%.It can thus be appreciated that supercritical carbon dioxide process comparatively alcohol reflux extracting process wogonin and the baicalin rate of transform all exceeds 10%, it is more complete that supercritical carbon dioxide process extracts active component, and the utilization rate of medical material is higher.
Meanwhile, supercritical CO 2 extraction technology receives cream rate, and comparatively alcohol reflux extracting process is low, and illustrate that in supercritical CO 2 extraction technology extract, non-active ingredient is few, in extract, impurity is few, of light color.
The in vitro penetrating absorption of experimental example 2 a kind of reed mentioned in ancient books art cataplasma
Isolated mouse penetrating absorption: get mice, fasting 24h before test, de-cervical vertebra is put to death, Mus hair is cut off with shears, dip depilatory depilation with Cotton Gossypii, warm water cleaning, by hair and residual depilatory, is dried, cut open from abdominal part, except decaptitating and extremity, peeling off whole skin, tearing interior fascia and subcutaneus adipose tissue etc. off, clean, for subsequent use.Get a kind of reed mentioned in ancient books art cataplasma, its ointment-containing body is about 1g, after precise, as sample in penetrating absorption.Adopt the Franz diffusion cell of improvement, diffusion cell receiving port diameter 3cm, area 7.012cm
2, receiving chamber's volume is 35.0ml, fills it up with normal saline in acceptance pool, guarantees bubble-free in reception tank.The Corium Mus prepared is fixed in acceptance pool, make skin depilatory towards upper, a kind of reed mentioned in ancient books art cataplasma is fixed on skin outer layer together with back lining materials, mastic is close to skin outer layer, Corium Mus internal layer is contacted completely with receiving liquid, and cut the unnecessary Corium Mus in side, transdermal test unit is in (37 ± 1) DEG C water bath heat preservation, open magnetic stirring bar to stir with the speed of 200r/min simultaneously, respectively at 2h, 4h, 8h, 12h takes out whole acceptable solution in acceptance pool, and adopt high performance liquid chromatography to carry out assay, add the fresh physiological saline of the pre-temperature of same volume to (37 ± 1) DEG C immediately simultaneously.
Result of the test: during 4h, baicalin skin permeation rate 13.4%, wogonin skin permeation rate is 21.4%.
Claims (6)
1. treat a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea, comprise ointment-containing body, it is characterized in that described ointment-containing body is made up of Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract and pharmaceutic adjuvant, described ointment-containing body is become by following components in mass portion array:
Described Radix Scutellariae and Rhizoma Atractylodis Macrocephalae extract are obtained by following methods: crude drug amount is that the Radix Scutellariae of 1:1 and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 30 ~ 40MPa extracting pressure and 25 ~ 35 DEG C of temperature, and extract is evaporated to thick paste.
2. a kind of a kind of reed mentioned in ancient books art cataplasma for the treatment of primary dysmenorrhea according to claim 1, is characterized in that: described a kind of reed mentioned in ancient books art cataplasma is become by following components in mass portion array:
3. a kind of a kind of reed mentioned in ancient books art cataplasma for the treatment of primary dysmenorrhea according to claim 1 and 2, is characterized in that: the pH value of the ointment-containing body of described a kind of reed mentioned in ancient books art cataplasma is 4.5 ~ 6.
4. treat a preparation method for a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea, it is characterized in that, described preparation method comprises the following steps:
(1) take Radix Scutellariae 10 ~ 50 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 50 parts by weight, Radix Scutellariae and the Rhizoma Atractylodis Macrocephalae adopt supercritical carbon dioxide extraction under 30 ~ 40MPa extracting pressure and 25 ~ 35 DEG C of temperature, and extract is evaporated to thick paste;
(2) thick paste prepared by step (1) is dissolved in 30 ~ 70 parts of deionized waters, mix homogeneously;
(3) in step (2), sodium sulfite 0.05 ~ 0.5 part, ethylenediaminetetraacetic acid 0.08 ~ 0.8 part, citric acid 0.1 ~ 5 part, carbomer 1 ~ 10 part is added, mix homogeneously;
(4) taking sodium polyacrylate NP7002 ~ 8 part is by weight dissolved in 5 ~ 35 parts of glycerol;
(5) Kaolin 1 ~ 5 part, dihydroxyaluminum aminoacetate 0.5 ~ 2 part, sorbitol 1 ~ 5 part, titanium dioxide 0.1 ~ 4 part is taken by weight, mix homogeneously;
(6) compositions prepared by step (5) is added in the compositions of step (4), mix homogeneously;
(7) compositions prepared by step (6) joined in compositions prepared by step (3), place ripening, coat on backing layer non-woven fabrics, add a cover adherent layer polyethylene film, lucifuge ventilation is dried naturally.
5. a kind of preparation method for the treatment of a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea according to claim 4, it is characterized in that: described extracting pressure is 35MPa, described temperature is 30 DEG C.
6. a kind of preparation method for the treatment of a kind of reed mentioned in ancient books art cataplasma of primary dysmenorrhea according to claim 4, is characterized in that the relative density of step (1) described thick paste is 1.0 ~ 1.1g/mL.
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