CN105433985A - Vascular endothelial function evaluation and detection system and method based on FMD - Google Patents
Vascular endothelial function evaluation and detection system and method based on FMD Download PDFInfo
- Publication number
- CN105433985A CN105433985A CN201510955386.6A CN201510955386A CN105433985A CN 105433985 A CN105433985 A CN 105433985A CN 201510955386 A CN201510955386 A CN 201510955386A CN 105433985 A CN105433985 A CN 105433985A
- Authority
- CN
- China
- Prior art keywords
- finger tip
- blood volume
- pulsation wave
- volume pulsation
- brachial artery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003845 vascular endothelial function Effects 0.000 title claims abstract description 61
- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000001514 detection method Methods 0.000 title claims abstract description 32
- 238000011156 evaluation Methods 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 claims abstract description 132
- 239000008280 blood Substances 0.000 claims abstract description 132
- 210000002302 brachial artery Anatomy 0.000 claims abstract description 80
- 230000017531 blood circulation Effects 0.000 claims abstract description 17
- 230000000903 blocking effect Effects 0.000 claims abstract description 13
- 230000010349 pulsation Effects 0.000 claims description 123
- 230000008859 change Effects 0.000 claims description 23
- 230000006870 function Effects 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 9
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 7
- 229910052744 lithium Inorganic materials 0.000 claims description 7
- 230000004872 arterial blood pressure Effects 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 6
- 230000008753 endothelial function Effects 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- YGLMVCVJLXREAK-MTVMDMGHSA-N 1,1-dimethyl-3-[(1S,2R,6R,7S,8R)-8-tricyclo[5.2.1.02,6]decanyl]urea Chemical compound C([C@H]12)CC[C@@H]1[C@@H]1C[C@@H](NC(=O)N(C)C)[C@H]2C1 YGLMVCVJLXREAK-MTVMDMGHSA-N 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 210000004204 blood vessel Anatomy 0.000 description 8
- 230000036772 blood pressure Effects 0.000 description 5
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 210000003038 endothelium Anatomy 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000008694 endothelial dysfunction Effects 0.000 description 2
- 210000003989 endothelium vascular Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000005428 wave function Effects 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010022562 Intermittent claudication Diseases 0.000 description 1
- 206010069384 Ischaemic nephropathy Diseases 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical class [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000004219 arterial function Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000021156 intermittent vascular claudication Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/02—Measuring pulse or heart rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The invention provides a vascular endothelial function evaluation and detection system and method based on the FMD. The blood volume pulse wave of a left fingertip and the blood volume pulse wave of a right fingertip are collected through a left fingertip blood volume pulse wave detector (81) and a right fingertip blood volume pulse wave detector (82) respectively. Pressurization is conducted on the brachial artery of a left arm or a right arm through a brachial artery pressurization cuff (9) so that blood circulation of the left arm or the right arm can be blocked. A host (4) calculates the vascular endothelial function situation index according to the changes of the left fingertip blood volume pulse wave area and the right fingertip blood volume pulse wave area before and after pressurization blocking of the brachial artery, the vascular endothelial function can be comprehensively evaluated, the blocking time of the brachial artery is shortened, and the system production cost is reduced.
Description
Technical field
The present invention relates to field of medical device, particularly relate to a kind of vascular endothelial function based on FMD assessment detection system and method.
Background technology
Blood circulation of human body system is the systematic entirety be made up of heart and blood vessel, blood vessel endothelium system is one of maximum Functional tissue of human body, normal smooth and blood flow unimpeded significant for maintaining blood vessel wall of the complete and vascular endothelial function of blood vessel endothelium.Normal blood vessel endothelium mainly has barrier function, acceptance and transmission of information function and secretory function.Clinical research shows no matter cardiovascular disease or peripheral blood vessel, and both common traits are vascular endothelium dysfunction.As apoplexy, myocardial infarction, ischemic nephropathy and intermittent claudication etc. have common pathologic basis, i.e. vascular endothelium dysfunction.
Cardiovascular disease group of people at high risk is carried out to the earlier detection of vascular endothelial function, note abnormalities, take some countermeasures in early days, prevention and retarding cardiovascular diseases are developed, there is very important meaning.Flow-mediated (FlowMediatedDilation, FMD) method is adopted usually to the detection of vascular endothelial function, also known as ultrasonic FMD method at present.Brachial artery is not only the position of Measure blood pressure, is also one important " window " detecting systemic arterial function.The common step of flow-mediated method is: first brachial artery position pressurization is blocked 5 ~ 10 minutes to brachial artery; Rapid release pressure afterwards, high speed blood flow is made to impact size Wall of Artery, high speed blood flow promotes the release of vascular relaxing factor (NO) to the shear force effect of blood vessel wall, and utilize accurate color ultrasound to observe the degrees of expansion of whole process medium vessels, and evaluate vascular endothelial function according to the degrees of expansion (rate of change of blood vessel diameter) of blood vessel.Ultrasonic FMD method evaluates the most frequently used non-invasive methods of vascular endothelial function, and its testing result is construed to be the golden index evaluating vascular endothelial function.But there is the shortcoming being difficult to overcome in ultrasonic FMD method, mainly need well-trained operator, dynamics, external environment and oneself state etc. that pressurization cuff tangent plane and probe press all can have an impact to result, and the cost of device therefor is very high, the flow-mediated parameter detected is the rate of change of brachial artery blood vessel diameter, its sensitivity lower (being no more than 71%).
For this reason, prior art proposes again the PAT method (PeripheralArteryTonometry) measuring the rate of change blocking finger tip tension force pulse wave amplitude before and after brachial artery flow on the basis of FMD method, when this rate of change and critical point higher than 1.68 time endothelial function normal.Compare with ultrasonic FMD method, its advantage is, simple and efficient to handle, and sensitivity brings up to 82%, can be used for early screening diagnosis vascular endothelial function.But PAT method still has weak point, mainly when information gathering, blocking brachial artery overlong time causes experimenter not easily to accept, and critical point only relies on the rate of change of finger tip tension force pulse wave amplitude to obtain, miss other effective ingredient of pulse wave, therefore more fully can't evaluate vascular endothelial function.
Summary of the invention
A kind of vascular endothelial function based on FMD is the object of the present invention is to provide to assess detection system and method, can comprehensive assessment vascular endothelial function, shorten brachial artery Xining, reduce system production cost.
For achieving the above object, the invention provides a kind of vascular endothelial function based on FMD assessment detection system, comprising: main frame, the display be connected with shown main frame, the left finger tip blood volume pulsation wave detector be connected with described main frame, right finger tip blood volume pulsation wave detector and brachial artery pressurize cuff;
Described left finger tip blood volume pulsation wave detector and right finger tip blood volume pulsation wave detector are respectively used to the blood volume pulsation wave gathering left finger tip and right finger tip;
Described display is for showing left finger tip blood volume pulsation wave and right finger tip blood volume pulsation wave and showing testing process and result;
Described brachial artery pressurization cuff is used for carrying out its blood flow of pressurization blocking-up to the brachial artery of left arm or right arm;
Described main frame is used for blocking the front and back change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area according to brachial artery pressurization, calculates vascular endothelial function status score.
The mainframe box that described main frame comprises main frame slave case and is connected with main frame slave case;
Described main frame slave case is electrically connected display, keyboard and Mus mark;
Described main frame slave case is provided with several display lamp, line voltmeter and several button;
Described mainframe box is provided with function socket and cuff socket, described mainframe box is electrically connected by this function socket and described left finger tip blood volume pulsation wave detector and right finger tip blood volume pulsation wave detector, is connected by this cuff socket and the described brachial artery cuff that pressurizes.
The brachial artery pressure processing module be provided with the second microprocessor in described main frame, being electrically connected with described second microprocessor and the display lamp driver module be electrically connected with described second microprocessor;
Described function socket and the second microprocessor are electrically connected;
Described brachial artery pressure processing module is connected by cuff socket and the described brachial artery cuff that pressurizes;
Described display lamp driver module and described several display lamp are electrically connected;
Described second microprocessor is also electrically connected industrial computer, and described industrial computer is electrically connected display screen and USB interface;
Described second microprocessor and industrial computer are all electrically connected lithium battery, and described lithium battery is electrically connected power source protective module.
Described left finger tip blood volume pulsation wave detector and right finger tip blood volume pulsation wave detector include: finger tip pulse transducer, the rc low pass filter be electrically connected with described finger tip pulse transducer, the follower be electrically connected with described rc low pass filter, the preamplifier be electrically connected with described follower, the active band-pass filter be electrically connected with described preamplifier, the digital-control amplifier be electrically connected with described active band-pass filter, the first impedance be electrically connected with described digital-control amplifier, and second impedance that with described digital-control amplifier be electrically connected in parallel with described first impedance, the reference power supply be electrically connected with described first and second impedances, and the first microprocessor to be electrically connected with described digital-control amplifier.
The present invention also provides a kind of vascular endothelial function based on FMD to assess detection method, comprises the steps:
Step 1, provide one based on the endothelial function assessment detection system of FMD, comprising: main frame, the display be connected with shown main frame, the left finger tip blood volume pulsation wave detector be connected with described main frame, right finger tip blood volume pulsation wave detector and brachial artery pressurize cuff;
Described left finger tip blood volume pulsation wave detector and right finger tip blood volume pulsation wave detector are connected to the left finger tip of experimenter and right finger tip respectively, and the cuff that pressurizeed by brachial artery is close to skin and is tied up brachial artery place in any side, the left and right of experimenter;
Step 2, startup main frame, the blood volume pulsation wave of the display described left finger tip of display and right finger tip;
Start to measure after the stable display of blood volume pulsation wave of step 3, described left finger tip and right finger tip, the left finger tip respectively in the fixing duration of collection one and the blood volume pulsation wave of right finger tip;
Step 4, constantly pressurize until after blocking brachial artery blood flow to brachial artery pressurization cuff, continue pressurization one fixation pressure value, block duration by the brachial artery of setting and keep brachial artery blocking-up;
Step 5, brachial artery block duration to be terminated, and brachial artery pressurization cuff is decompressed to zero, starts flow-mediated process;
Step 6, gather the left finger tip of fixing duration identical with step 3 and the blood volume pulsation wave of right finger tip respectively;
Step 7, carry out date processing to the blood volume pulsation wave of left finger tip and right finger tip, the change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area before and after blocking according to brachial artery pressurization, calculate vascular endothelial function status score.
Fixing duration in described step 3 and step 6 is 40 seconds.
The brachial artery Xining of the setting in described step 4 is 2 ~ 3 minutes.
Described step 7 comprises:
Step 71, utilize Fourier formula that the blood volume pulsation wave of left finger tip and right finger tip is resolved into several harmonic component, each harmonic component has the harmonic component amplitude of a correspondence and the frequencies of harmonic components of a correspondence;
Left finger tip in fixing duration in fixing duration in step 72, respectively selected step 3 in left finger tip and right finger tip blood volume pulsation wave and step 6 and the blood volume pulsation wave of right finger tip, calculate the meansigma methods of the area representated by low frequency component of each selected blood volume pulsation wave;
For the blood volume pulsation wave that each is selected, the mean value calculation process of the representative area of its blood volume pulsation wave low frequency component is:
Select 5 points adjacent with the frequencies of harmonic components of 0.5Hz, 1.0Hz, 1.5Hz and 2.0Hz respectively, amount to 20 points, the harmonic component of these 20 some correspondences is low frequency component, obtain the amplitude of the low frequency component of these 20 some correspondences, these 20 points are all positioned at fixing duration corresponding to this selected blood volume pulsation wave;
Calculate the area representated by each low frequency component, formula is:
σ
n＝A
n×Δt，
Wherein, Δ t=1ms, n be more than or equal to 1 and be less than or equal to 20 positive integer, A
nfor the amplitude of n-th that chooses described in step 2 corresponding low frequency component, σ
narea representated by low frequency component corresponding to choose described in step 2 n-th;
Calculate the meansigma methods of the area representated by low frequency component of this section of selected blood volume pulsation wave, formula is;
Wherein, the meansigma methods of the area of f representated by the low frequency component of this section of blood volume pulsation wave;
Step 73, calculating vascular endothelial function status score, formula is:
Q＝(fb×fc)/(fa×fd)
Wherein, Q is vascular endothelial function status score; Fa, fc are respectively the meansigma methods of the area representated by low frequency component of left finger tip and the right finger tip blood volume pulsation wave gathered in step 3; Fb, fd are respectively the meansigma methods of the area representated by low frequency component of left finger tip and the right finger tip blood volume pulsation wave gathered in step 6.
Beneficial effect of the present invention: the invention provides a kind of vascular endothelial function based on FMD assessment detection system and method, the blood volume pulsation wave of left finger tip and right finger tip is gathered respectively by left finger tip blood volume pulsation wave detector and right finger tip blood volume pulsation wave detector, the brachial artery of brachial artery pressurization cuff to left arm or right arm carries out its blood flow of pressurization blocking-up, the change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area before and after described main frame blocks according to brachial artery pressurization, calculate vascular endothelial function status score, can comprehensive assessment vascular endothelial function, shorten brachial artery Xining, reduction system production cost.
In order to further understand feature of the present invention and technology contents, refer to following detailed description for the present invention and accompanying drawing, but accompanying drawing only provides reference and explanation use, is not used for being limited the present invention.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, by the specific embodiment of the present invention describe in detail, will make technical scheme of the present invention and other beneficial effect apparent.
In accompanying drawing,
Fig. 1 is the structural representation of the vascular endothelial function based on FMD of the present invention assessment detection system;
Fig. 2 is the system module figure of the vascular endothelial function based on FMD of the present invention assessment detection system;
Fig. 3 is the schematic diagram of finger tip blood volume pulsation wave detector in the vascular endothelial function based on FMD of the present invention assessment detection system;
Fig. 4 is the schematic diagram of the main frame in the vascular endothelial function based on FMD of the present invention assessment detection system;
Fig. 5 is the schematic diagram of the power supply in the vascular endothelial function based on FMD of the present invention assessment detection system;
Fig. 6 is the flow chart of the vascular endothelial function based on FMD of the present invention assessment detection method.
Detailed description of the invention
For further setting forth the technological means and effect thereof that the present invention takes, be described in detail below in conjunction with the preferred embodiments of the present invention and accompanying drawing thereof.
Refer to Fig. 1 and Fig. 2, the invention provides a kind of vascular endothelial function based on FMD assessment detection system, comprising: main frame 4, the display 1 be connected with shown main frame 4, the left finger tip blood volume pulsation wave detector 81 be connected with described main frame 4, right finger tip blood volume pulsation wave detector 82 and brachial artery pressurize cuff 9;
Described left finger tip blood volume pulsation wave detector 81 and right finger tip blood volume pulsation wave detector 82 are respectively used to the blood volume pulsation wave gathering left finger tip and right finger tip;
Described display 1 is for showing left finger tip blood volume pulsation wave and right finger tip blood volume pulsation wave and showing testing process and result;
Described brachial artery pressurization cuff 9 blocks its blood flow for carrying out pressurization to the brachial artery of left arm or right arm;
Described main frame 4, for blocking the front and back change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area according to brachial artery pressurization, calculates vascular endothelial function status score.
Concrete, the mainframe box 42 that described main frame 4 comprises main frame slave case 41 and is connected with main frame slave case 41; Described main frame slave case 41 is electrically connected display 1, keyboard 31 and mouse 32; Described main frame slave case 41 is provided with several display lamp 411, line voltmeter 412 and several button 412; Described mainframe box 42 is provided with function socket 422 and cuff socket 423, described mainframe box 42 is electrically connected by this function socket 422 and described left finger tip blood volume pulsation wave detector 81 and right finger tip blood volume pulsation wave detector 82, is connected by this cuff socket 423 and the described brachial artery cuff 9 that pressurizes.
Further, below described display screen 1, be provided with display/panel bracket 2, in described display/panel bracket 2, be provided with VGA cable and power cable passage; Described display screen 1 is electrically connected by this VGA cable passage and main frame slave case 41; The shift knob of described feed cable in several button 412 is electrically connected lithium battery 102.
Concrete, the brachial artery pressure processing module 425 refer to Fig. 4 and Fig. 5, be provided with the second microprocessor 424 in described main frame 4, being electrically connected with described second microprocessor 424 and the display lamp driver module 426 be electrically connected with described second microprocessor 424; Described function socket 422 and the second microprocessor 424 are electrically connected; Described brachial artery pressure processing module 424 is connected by cuff socket 423 and the described brachial artery cuff 9 that pressurizes; Described display lamp driver module 426 is electrically connected with described several display lamp 411; Described second microprocessor 424 is also electrically connected industrial computer 100, and described industrial computer 100 is electrically connected display screen 1 and usb 1 01; Described second microprocessor 424 and industrial computer 100 shift knob all in several button 412 is electrically connected lithium battery 102; described lithium battery 102 is electrically connected power source protective module 103, is powered to described main frame 4, industrial computer 100 and display 1 by this lithium ion battery 102.
Concrete, refer to Fig. 3, described left finger tip blood volume pulsation wave detector 81 and right finger tip blood volume pulsation wave detector 82 include: finger tip pulse transducer 811, the rc low pass filter 812 be electrically connected with described finger tip pulse transducer 811, the follower 813 be electrically connected with described rc low pass filter 812, the preamplifier 814 be electrically connected with described follower 813, the active band-pass filter 815 be electrically connected with described preamplifier 814, the digital-control amplifier 819 be electrically connected with described active band-pass filter 815, the first impedance 817 be electrically connected with described digital-control amplifier 819, and second impedance 818 that with described digital-control amplifier 819 be electrically connected in parallel with described first impedance 817, with described first and second impedances 818, 817 reference power supplies 816 be electrically connected, and the first microprocessor 820 to be electrically connected with described digital-control amplifier 819.Further, described active band-pass filter 815 electricity connection function socket 422, makes main frame 4 be electrically connected with described left finger tip blood volume pulsation wave detector 81 and right finger tip blood volume pulsation wave detector 82.Preferably, the model of described follower 813 is LT1112, and the model of described band filter 815 is RC4558, and the voltage of described reference power supply 816 is 1.5V.
Further, the described vascular endothelial function based on FMD assessment detection system also comprise be electrically connected with described main frame 4 printer 5, for place printer 5 chassis bracket 6, be installed on wheel 7 below described chassis bracket 6.
It is worth mentioning that, the present invention proposes one because of blood flow and changes the characteristic quantity F value being changed to basis of the pulse waveform area caused, and defines its value and be:
F＝(Vm－VD)/(VS－VD)
Or Vm=VD+Q (VS-VD)
In formula,
Vm is mean blood flow, equals the meansigma methods of blood flow in a cardiac cycle, and f (t) is pulse wave function,
for pulse waveform area, VS, VD are respectively peak value blood flow and residual blood volume, and the area covered between pulse waveform area and VS and VD, T is cardiac cycle.
Refer to Fig. 6, the present invention also provides a kind of vascular endothelial function based on FMD to assess detection method, comprises the steps:
Step 1, provide one based on the vascular endothelial function assessment detection system of FMD, comprising: main frame 4, the display 1 be connected with shown main frame 4, the left finger tip blood volume pulsation wave detector 81 be connected with described main frame 4, right finger tip blood volume pulsation wave detector 82 and brachial artery pressurize cuff 9;
Described left finger tip blood volume pulsation wave detector 81 and right finger tip blood volume pulsation wave detector 82 are connected to the left finger tip of experimenter and right finger tip respectively, and the cuff 9 that pressurizeed by brachial artery is close to skin and is tied up brachial artery place in any side, the left and right of experimenter;
Concrete, described brachial artery pressurization cuff 9 routinely Measure blood pressure method ties up the brachial artery place of any side of left and right arm in experimenter, and described general measure blood pressure method is the method adopting the blood pressure measuring comprising cuff to take blood pressure.Further, this step 1 can also comprise input experimenter's data and set up experimenter's archives.
Step 2, startup main frame 4, display 1 shows the blood volume pulsation wave of described left finger tip and right finger tip;
Start to measure after the stable display of blood volume pulsation wave of step 3, described left finger tip and right finger tip, the left finger tip respectively in the fixing duration of collection one and the blood volume pulsation wave of right finger tip;
Step 4, to brachial artery pressurization cuff 9 constantly pressurization until after blocking brachial artery blood flow, continue pressurization one fixation pressure value, block duration by the brachial artery of setting and keep brachial artery to block.
Concrete, the fixation pressure value continuing pressurization is 50 millimetress of mercury.
Step 5, brachial artery block duration and arrive, and brachial artery pressurization cuff 9 is decompressed to zero, starts flow-mediated process.
Concrete, it is 2 ~ 3 minutes that described brachial artery blocks duration, is preferably 3 minutes, blocks duration, effectively reduce brachial artery and block duration, more easily accepted by experimenter compared to the brachial artery of at least 5 minutes in prior art.
Step 6, gather the left finger tip of fixing duration identical with step 3 and the blood volume pulsation wave of right finger tip respectively.
Concrete, the fixing duration in described step 3 and step 6 is 40 seconds.The time period at two fixing duration places can be selected in the region of not obviously interference.
Step 7, date processing is carried out to the blood volume pulsation wave of described left finger tip and right finger tip, the change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area before and after blocking according to brachial artery pressurization, calculate vascular endothelial function status score.
Concrete, described step 7 comprises:
Step 71, utilize Fourier formula that the blood volume pulsation wave of left finger tip and right finger tip is resolved into several harmonic component, each harmonic component has the harmonic component amplitude of a correspondence and the frequencies of harmonic components of a correspondence;
Left finger tip in fixing duration in fixing duration in step 72, respectively selected step 3 in left finger tip and right finger tip blood volume pulsation wave and step 6 and the blood volume pulsation wave of right finger tip, calculate the meansigma methods of the area representated by low frequency component of each selected blood volume pulsation wave;
For the blood volume pulsation wave that each is selected, the mean value calculation process of the representative area of its blood volume pulsation wave low frequency component is:
Select 5 points adjacent with the frequencies of harmonic components of 0.5Hz, 1.0Hz, 1.5Hz and 2.0Hz respectively, amount to 20 points, the harmonic component of these 20 some correspondences is low frequency component, obtain the amplitude of the low frequency component of these 20 some correspondences, these 20 points are all positioned at fixing duration corresponding to this selected blood volume pulsation wave;
Calculate the area representated by each low frequency component, formula is:
σ
n＝A
n×Δt，
Wherein, Δ t=1ms, n be more than or equal to 1 and be less than or equal to 20 positive integer, A
nfor the amplitude of n-th that chooses described in step 2 corresponding low frequency component, σ
narea representated by low frequency component corresponding to choose described in step 2 n-th;
Calculate the meansigma methods of the area representated by low frequency component of this section of selected blood volume pulsation wave, formula is:
Wherein, the meansigma methods of the area of f representated by the low frequency component of this section of blood volume pulsation wave;
Step 73, calculating vascular endothelial function status score, formula is:
Q＝(fb×fc)/(fa×fd)
Wherein, Q is vascular endothelial function status score; Fa, fc are respectively the meansigma methods of the area representated by low frequency component of left finger tip and the right finger tip blood volume pulsation wave gathered in step 3; Fb, fd are respectively the meansigma methods of the area representated by low frequency component of left finger tip and the right finger tip blood volume pulsation wave gathered in step 6.Further, the computing formula of above-mentioned vascular endothelial function status score eliminates the impact of the many factors such as system, nerve, breathing, autonomous or external interference, thus obtains the actual value of endothelial function.
It is worth mentioning that, the procedure declaration blood volume pulsation wave utilizing Fourier formula by left finger tip and right finger tip in described step 71 being resolved into several harmonic component is as follows:
First low pass is done to blood volume pulsation wave, active band leads to pretreatment, remove baseline drift and even up bottom blood volume pulsation wave, utilize the wavelet transformation technique giving prominence to low frequency component to simplify computational process;
Then, Fourier analysis is done to blood volume pulsation wave function f (t);
Fourier formula according to periodic function has:
Wherein, T is cardiac cycle,
for DC component (i.e. residual blood volume); a
1cos Ω t+b
1sin Ω t is fundametal compoment, a
ncos Ω t+b
nsinn Ω t is nth harmonic component, n > 1;
Further,
Finally, the computing formula of the amplitude An of nth harmonic component is:
The frequency of nth harmonic component is: n Ω/2 π.
Said process completes by arranging Fourier analysis program in main frame 4, the blood volume pulsation wave of left finger tip and right finger tip is resolved into several harmonic component by this Fourier analysis program, and set up the data base of this harmonic component amplitude and frequencies of harmonic components, be kept in main frame 4;
It is worth mentioning that, can vascular endothelial function be assessed by the concrete numerical value of this vascular endothelial function status score Q, wherein:
As Q > 1.38, vascular endothelial function is normal;
As 1.10 < Q < 1.35, there is latent lesion in vascular endothelial function;
As Q < 1.05, vascular endothelial function is badly damaged.
In addition, can several functions be further expanded according to the present invention, comprise: measure cardiovascular quality factor, observe state aroused in interest, QI and blood state, autonomic nerve state, observation store the many kinds of parameters such as pulse wave.
In sum, the invention provides a kind of vascular endothelial function based on FMD assessment detection system and method, the blood volume pulsation wave of left finger tip and right finger tip is gathered respectively by left finger tip blood volume pulsation wave detector and right finger tip blood volume pulsation wave detector, the brachial artery of brachial artery pressurization cuff to left arm or right arm carries out its blood flow of pressurization blocking-up, the change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area before and after described main frame blocks according to brachial artery pressurization, calculate vascular endothelial function status score, can comprehensive assessment vascular endothelial function, shorten brachial artery Xining, reduction system production cost.
The above, for the person of ordinary skill of the art, can make other various corresponding change and distortion according to technical scheme of the present invention and technical conceive, and all these change and be out of shape the protection domain that all should belong to the claims in the present invention.
Claims (9)
1. the assessment of the vascular endothelial function based on a FMD detection system, it is characterized in that, comprising: main frame (4), the display (1) be connected with shown main frame (4), left finger tip blood volume pulsation wave detector (81) be connected with described main frame (4), right finger tip blood volume pulsation wave detector (82) and brachial artery pressurize cuff (9);
Described left finger tip blood volume pulsation wave detector (81) and right finger tip blood volume pulsation wave detector (82) are respectively used to the blood volume pulsation wave gathering left finger tip and right finger tip;
Described display (1) is for showing left finger tip blood volume pulsation wave and right finger tip blood volume pulsation wave and showing testing process and result;
Described brachial artery pressurization cuff (9) blocks its blood flow for carrying out pressurization to the brachial artery of left arm or right arm;
Described main frame (4), for blocking the front and back change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area according to brachial artery pressurization, calculates vascular endothelial function status score.
2. as claimed in claim 1 based on the vascular endothelial function assessment detection system of FMD, it is characterized in that, the mainframe box (42) that described main frame (4) comprises main frame slave case (41) and is connected with main frame slave case (41);
Described main frame slave case (41) is electrically connected display (1), keyboard (31) and mouse (32);
Described main frame slave case (41) is provided with several display lamp (411), line voltmeter (412) and several button (412);
Described mainframe box (42) is provided with function socket (422) and cuff socket (423), described mainframe box (42) is electrically connected by this function socket (422) and described left finger tip blood volume pulsation wave detector (81) and right finger tip blood volume pulsation wave detector (82), is connected by this cuff socket (423) and the described brachial artery cuff (9) that pressurizes.
3. as claimed in claim 2 based on the vascular endothelial function assessment detection system of FMD, the brachial artery pressure processing module (425) it is characterized in that, be provided with the second microprocessor (424) in described main frame (4), being electrically connected with described second microprocessor (424) and the display lamp driver module (426) be electrically connected with described second microprocessor (424);
Described function socket (422) and the second microprocessor (424) are electrically connected;
Described brachial artery pressure processing module (425) is connected by cuff socket (423) and the described brachial artery cuff (9) that pressurizes;
Described display lamp driver module (426) and described several display lamp (411) are electrically connected.
4. as claimed in claim 3 based on the vascular endothelial function assessment detection system of FMD, it is characterized in that, described second microprocessor (424) is also electrically connected industrial computer (100), and described industrial computer (100) is electrically connected display screen (1) and USB interface (101);
Described second microprocessor (424) and industrial computer (100) are all electrically connected lithium battery (102), and described lithium battery (102) is electrically connected power source protective module (103).
5. as claimed in claim 3 based on the vascular endothelial function assessment detection system of FMD, it is characterized in that, described left finger tip blood volume pulsation wave detector (81) and right finger tip blood volume pulsation wave detector (82) include: finger tip pulse transducer (811), the rc low pass filter (812) be electrically connected with described finger tip pulse transducer (811), the follower (813) be electrically connected with described rc low pass filter (812), the preamplifier (814) be electrically connected with described follower (813), the active band-pass filter (815) be electrically connected with described preamplifier (814), the digital-control amplifier (819) be electrically connected with described active band-pass filter (815), the first impedance (817) be electrically connected with described digital-control amplifier (819), and second impedance (818) that with described digital-control amplifier (819) be electrically connected in parallel with described first impedance (817), with described first and second impedances (817, 818) reference power supply (816) be electrically connected, and the first microprocessor (820) to be electrically connected with described digital-control amplifier (819).
6., based on a vascular endothelial function assessment detection method of FMD, it is characterized in that, comprise the steps:
Step 1, provide one based on the endothelial function assessment detection system of FMD, comprising: main frame (4), the display (1) be connected with shown main frame (4), left finger tip blood volume pulsation wave detector (81) be connected with described main frame (4), right finger tip blood volume pulsation wave detector (82) and brachial artery pressurize cuff (9);
Described left finger tip blood volume pulsation wave detector (81) and right finger tip blood volume pulsation wave detector (82) are connected to respectively left hand finger tip and the right hand finger tip of experimenter, the cuff (9) that pressurizeed by brachial artery is close to skin and is tied up brachial artery place in any side, the left and right of experimenter;
Step 2, startup main frame (4), display (1) shows the blood volume pulsation wave of described left finger tip and right finger tip;
Start to measure after the stable display of blood volume pulsation wave of step 3, described left finger tip and right finger tip, gather the fixing left finger tip of duration and a blood volume pulsation wave for right finger tip respectively;
Step 4, to brachial artery pressurization cuff (9) constantly pressurization until after blocking brachial artery blood flow, continue pressurization one fixation pressure value, block duration by the brachial artery of setting and keep brachial artery to block;
Step 5, brachial artery block duration to be terminated, and brachial artery pressurization cuff (9) is decompressed to zero, starts flow-mediated process;
Step 6, gather the left finger tip of fixing duration identical with step 3 and the blood volume pulsation wave of right finger tip respectively;
Step 7, carry out date processing to the blood volume pulsation wave of left finger tip and right finger tip, the change of left finger tip blood volume pulsation wave area and the change of right finger tip blood volume pulsation wave area before and after blocking according to brachial artery pressurization, calculate vascular endothelial function status score.
7. as claimed in claim 6 based on the vascular endothelial function assessment detection method of FMD, it is characterized in that, the fixing duration in described step 3 and step 6 is 40 seconds.
8., as claimed in claim 6 based on the vascular endothelial function assessment detection method of FMD, it is characterized in that, it is 2 ~ 3 minutes that the brachial artery of the setting in described step 4 blocks duration.
9., as claimed in claim 6 based on the vascular endothelial function assessment detection method of FMD, it is characterized in that, described step 7 comprises:
Step 71, utilize Fourier formula that the blood volume pulsation wave of left finger tip and right finger tip is resolved into several harmonic component, each harmonic component has the harmonic component amplitude of a correspondence and the frequencies of harmonic components of a correspondence;
Left finger tip in fixing duration in fixing duration in step 72, respectively selected step 3 in left finger tip and right finger tip blood volume pulsation wave and step 6 and the blood volume pulsation wave of right finger tip, calculate the meansigma methods of the area representated by low frequency component of each selected blood volume pulsation wave;
For the blood volume pulsation wave that each is selected, the mean value calculation process of the representative area of its blood volume pulsation wave low frequency component is:
Select 5 points adjacent with the frequencies of harmonic components of 0.5Hz, 1.0Hz, 1.5Hz and 2.0Hz respectively, amount to 20 points, the harmonic component of these 20 some correspondences is low frequency component, obtain the amplitude of the low frequency component of these 20 some correspondences, these 20 points are all positioned at fixing duration corresponding to this selected blood volume pulsation wave;
Calculate the area representated by each low frequency component, formula is:
σ
n＝A
n×Δt，
Wherein, Δ t=1ms, n be more than or equal to 1 and be less than or equal to 20 positive integer, A
nfor the amplitude of n-th that chooses described in step 2 corresponding low frequency component, σ
narea representated by low frequency component corresponding to choose described in step 2 n-th;
Calculate the meansigma methods of the area representated by low frequency component of this section of selected blood volume pulsation wave, formula is:
Wherein, the meansigma methods of the area of f representated by the low frequency component of this section of blood volume pulsation wave;
Step 73, calculating vascular endothelial function status score, formula is:
Q＝(fb×fc)/(fa×fd)
Wherein, Q is vascular endothelial function status score; Fa, fc are respectively the meansigma methods of the area representated by low frequency component of left finger tip and the right finger tip blood volume pulsation wave gathered in step 3; Fb, fd are respectively the meansigma methods of the area representated by low frequency component of left finger tip and the right finger tip blood volume pulsation wave gathered in step 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510955386.6A CN105433985A (en) | 2015-12-17 | 2015-12-17 | Vascular endothelial function evaluation and detection system and method based on FMD |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510955386.6A CN105433985A (en) | 2015-12-17 | 2015-12-17 | Vascular endothelial function evaluation and detection system and method based on FMD |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105433985A true CN105433985A (en) | 2016-03-30 |
Family
ID=55544942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510955386.6A Pending CN105433985A (en) | 2015-12-17 | 2015-12-17 | Vascular endothelial function evaluation and detection system and method based on FMD |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105433985A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105852910A (en) * | 2016-04-18 | 2016-08-17 | 何宗彦 | Equipment and method for detecting vascular endothelial functions by Doppler ultrasonography |
| CN110236490A (en) * | 2019-05-05 | 2019-09-17 | 广东省医疗器械研究所 | A kind of noninvasive function of vascular endothelium diagnostic equipment and its implementation |
| CN113951846A (en) * | 2021-12-17 | 2022-01-21 | 北京麦邦光电仪器有限公司 | Pulse wave signal processing method and device and readable storage medium |
| CN116687360A (en) * | 2023-07-28 | 2023-09-05 | 中国科学院合肥物质科学研究院 | Vascular endothelial function assessment method and system based on index fusion |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121798A (en) * | 1994-08-16 | 1996-05-08 | 北京工业大学 | Cardiovascular function dynamic parameter testing analysis method and apparatus |
| US20080081963A1 (en) * | 2006-09-29 | 2008-04-03 | Endothelix, Inc. | Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress |
| US20100081941A1 (en) * | 2006-03-22 | 2010-04-01 | Endothelix, Inc. | Cardiovascular health station methods and apparatus |
| CN102551688A (en) * | 2012-01-31 | 2012-07-11 | 成怀畅 | Endothelial cell function screening and diagnosing apparatus |
| CN102743165A (en) * | 2012-07-31 | 2012-10-24 | 刘常春 | Blood in vivo liquidity measuring device based on photoelectric volume pulse wave |
| CN205251573U (en) * | 2015-12-17 | 2016-05-25 | 深圳前海圣晔尔医疗电子生物科技有限公司 | Endothelial function aassessment detecting system based on FMD |
-
2015
- 2015-12-17 CN CN201510955386.6A patent/CN105433985A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121798A (en) * | 1994-08-16 | 1996-05-08 | 北京工业大学 | Cardiovascular function dynamic parameter testing analysis method and apparatus |
| US20100081941A1 (en) * | 2006-03-22 | 2010-04-01 | Endothelix, Inc. | Cardiovascular health station methods and apparatus |
| US20080081963A1 (en) * | 2006-09-29 | 2008-04-03 | Endothelix, Inc. | Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress |
| CN102551688A (en) * | 2012-01-31 | 2012-07-11 | 成怀畅 | Endothelial cell function screening and diagnosing apparatus |
| CN102743165A (en) * | 2012-07-31 | 2012-10-24 | 刘常春 | Blood in vivo liquidity measuring device based on photoelectric volume pulse wave |
| CN205251573U (en) * | 2015-12-17 | 2016-05-25 | 深圳前海圣晔尔医疗电子生物科技有限公司 | Endothelial function aassessment detecting system based on FMD |
Non-Patent Citations (2)
| Title |
|---|
| 于鹏飞: "基于Windows CE的内皮功能诊断仪软硬件平台设计", 《吉林大学硕士学位论文》 * |
| 罗志昌 等: ""脉搏波波形特征信息的研究"", 《北京工业大学学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105852910A (en) * | 2016-04-18 | 2016-08-17 | 何宗彦 | Equipment and method for detecting vascular endothelial functions by Doppler ultrasonography |
| CN110236490A (en) * | 2019-05-05 | 2019-09-17 | 广东省医疗器械研究所 | A kind of noninvasive function of vascular endothelium diagnostic equipment and its implementation |
| CN113951846A (en) * | 2021-12-17 | 2022-01-21 | 北京麦邦光电仪器有限公司 | Pulse wave signal processing method and device and readable storage medium |
| CN116687360A (en) * | 2023-07-28 | 2023-09-05 | 中国科学院合肥物质科学研究院 | Vascular endothelial function assessment method and system based on index fusion |
| CN116687360B (en) * | 2023-07-28 | 2023-10-24 | 中国科学院合肥物质科学研究院 | Vascular endothelial function assessment method and system based on index fusion |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Huotari et al. | Photoplethysmography and its detailed pulse waveform analysis for arterial stiffness | |
| KR20170087855A (en) | Automated diagnosis based at least in part on pulse waveforms | |
| CN103989463B (en) | A kind of radial artery pulse wave detection system based on fingertip pulse wave and method | |
| CN205251573U (en) | Endothelial function aassessment detecting system based on FMD | |
| CN105433985A (en) | Vascular endothelial function evaluation and detection system and method based on FMD | |
| Narayanan et al. | Cardiac Disorder Diagnosis Through Nadi (Pulse) Using Piezoelectric Sensors | |
| CN110840405A (en) | Manufacturing method of flexible array sensor and pulse condition detection system based on flexible array sensor | |
| CN104856647B (en) | Hemodynamics measuring apparatus and hemodynamics measuring method | |
| CN104000573A (en) | Body surface two point pulse wave based central arterial pulse monitoring system and method | |
| CN102197996A (en) | A Method for Obtaining Aortic Pulse Wave Velocity Using Radial Artery Pulse Wave | |
| Conoci et al. | Live demonstration of portable systems based on silicon sensors for the monitoring of physiological parameters of driver drowsiness and pulse wave velocity | |
| Kalange et al. | Nadi Parikshan Yantra and analysis of radial pulse | |
| Li et al. | The correlation study of Cun, Guan and Chi position based on wrist pulse characteristics | |
| CN106821308A (en) | The method and apparatus of contraction movement assessment under a kind of skeletal muscle stimulating | |
| Tejaswini et al. | Detection and prediction of osteoporosis using impulse response technique and artificial neural network | |
| Selvan et al. | Nadi Aridhal: A pulse based automated diagnostic system | |
| CN102551688A (en) | Endothelial cell function screening and diagnosing apparatus | |
| CN103340626B (en) | Device for evaluating human body four-limb edema based on biological impedance and use method thereof | |
| Miah et al. | Low cost computer based heart rate monitoring system using fingertip and microphone port | |
| TWI516247B (en) | Method for analyzing emotional physiological signals of depressive tendency for home care | |
| CN206950180U (en) | A kind of multi-functional blood oxygen stethoscope | |
| RU118534U1 (en) | DEVICE FOR ASSESSING ARTERIAL FUNCTION | |
| CN102138864B (en) | Monitoring and evaluating method and monitoring and evaluating device of acupuncture treatment effect | |
| CN205144602U (en) | Human energy consumption monitoring devices and bracelet thereof | |
| Shete et al. | Pulse diagnosis based automated diagnostic system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160330 |