CN1054288C - Plaster for treating cancer pain - Google Patents

Abstract

The plaster for treating cancer pain adopts Chinese herbal medicines such as frankincense, myrrh, short-pedicel aconite root, kusnezoff monkshood root, raw arisaema tuber, raw pinellia tuber, borneol, natural bezoar, musk and the like as raw materials to prepare the plaster, can realize the effects of dredging collaterals, activating blood circulation, clearing heat, removing toxicity, promoting blood circulation, relieving swelling, softening nodes and dissipating hard mass, has good pain relieving effect, the effective rate can reach 96 percent, the effective rate for liver cancer patients can reach 100 percent, and has no toxic or side effect.

Description

The plaster of applying ointment or plaster of treatment cancer pain

The invention belongs to a kind of Chinese medicine lotion for external use medicine for the treatment of cancer pain.

Cancer pain is one of serious symptoms of cancer patient, aspect external therapy of Chinese herb, main adapted toxicity is than acute Semen Strychni, Venenum Bufonis, Rhizoma Arisaematis, living river bird, Realgar etc., use wider external application analgesic that " toad venom plaster ", " ruyi jinhuang powder, ruyi jinhuang san " (Radix Trichosanthis, Realgar, Myrrha, skin pin etc.), " analgesia detumescence ointment " (Venenum Bufonis, Semen Strychni, river bird, Rhizoma Arisaematis etc.) etc. are arranged at present, the effective percentage of these plaster and has stimulation to skin when using generally about 70～90%.

The external of the treatment cancer pain that the present invention aims to provide a kind of good analgesic effect of easing pain, has no side effect, effective percentage the is high plaster of applying ointment or plaster.

For achieving the above object, this plaster adopts following material composition and weight proportion (wherein b is Unit Weight part):

Olibanum 5～8b Myrrha 5～8b Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5～8b

Radix Aconiti Kusnezoffii 2～4b Rhizoma Arisaematis 5～8b Rhizoma Pinelliae 5～8b

Borneolum Syntheticum 5～8b natural Calculus Bovis 1～3b Moschus 1～3b

Above-mentioned raw materials is processed into the application plaster pharmaceutically dosage form.

Manufacture method is Olibanum, Myrrha, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae to be broken into granule put into and soak 7～15 days in the oil cauldron; put again and heat parch in the iron pan; treat with soaking oil it to be exploded withered removing slag after the drug particles drying; with being smelt the Cheng Zhuwei degree that drips again after the oil filtration; at last temperature is controlled at and adds Calculus Bovis, Moschus, Borneolum Syntheticum about 80 ℃ and stir evenly, after the cooled and solidified ointment is spread out on black cloth or the scytoblastema plaster.

During use plaster heated launch after, apply ointment or plaster at sore place, be suitable for treating various cancer pain at late stage.Particularly best to the hepatocarcinoma pain analgesic effect.

The traditional Chinese medical science is thought " stagnation of QI and blood may bring about pain ", so traditional therapy is all based on blood circulation promoting and blood stasis dispelling, it is considered herein that cancer pain is that multiple factor forms, therefore this pain is all relevant with " malicious, evil, strongly fragrant, stagnant ", has determined that executing of " collateral dredging being invigorated blood circulation, heat-clearing and toxic substances removing, promoting blood circulation and detumescence, soft junction loose hardly " control principle.Olibanum in the above-mentioned prescription, Myrrha have the effect of promoting blood circulation and stopping pain, cooling blood and relieving pain; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae, Moschus, Borneolum Syntheticum can be removed the poison heresy, pain relieving is had one's ideas straightened out; Calculus Bovis is heat-clearing and toxic substances removing, endogenous wind stopping pain relieving class medicine; it has cooling blood and relieving pain, strengthens the effect of blood circulation promoting and dispersing pathogen accumulation; Moschus is the product that blood circulation promoting and dispersing pathogen accumulation, pain relieving are had one's ideas straightened out, and its property of walking to scurry is very strong, can have an effect at painful area rapidly; being used of said medicine can be played significant analgesic effect.

This medicine heated directly spreads on the painful area body surface, can produce analgesic effect in general ten minutes, exchanges cards containing all personal details and become sworn brothers once in 3～5 days, after the pain relief, pastes 3～5 times again, can consolidate curative effect.

This medicine is made clinical observation on the therapeutic effect to 300 routine patients, by WHO fixed curative effect grade scale statistics, effective percentage reaches 96%, and is particularly more outstanding to the liver cancer patient effect, up to 100%.Be two parts of clinical observation statistical tables below.

Table one 300 routine cancer pain classification curative effect table curative effect pain degrees amount to

I level II level III level IV level disappear 87 42 10 7 159 (52%) alleviate 38 33 40 21 132 (44%) unchanged 01247 (2.3%) aggravation 12205 (1.7%) subtotals 126 (42%) 78 (26%) 54 (18%) 42 (14%) 300 (100%)

More than show statistical result, with total effective 288 people of " subsides of Du Shi cancer pain " treatment pain at different levels, total effective rate 96%, the pain rank is lower, and analgesic effect is more obviously.Cancer pain classification observation of curative effect table

Table two 300 routine cancer pain classification curative effect table curative effect cancer classifications amount to

Other cancer of liver cancer lung cancer cancer of the stomach osteocarcinoma lymph cancer disappears 115 18 18 140 156, (52%) alleviates 101 99841 132, (44%) unchanged 0006107, (2.3%) aggravation 0013015, (1.7%) subtotal 216, (72%) 27, (9%) 28, (9.4%) 18, (6%) 9, (3%) 2, (0.6%) 300, (100%)

This plaster is made skin anaphylactic test through Shanxi Medical College Institute of Basic Medical Sciences to Cavia porcellus, and conclusion is that Cavia porcellus is not had irritated effect.To also finding no any side effect and untoward reaction in 300 routine patients' the clinical trial.

Analgesic effect of the present invention is definite, and pain relieving is fast, and total effective rate can reach 96%, can reach 100% to the liver cancer patient effective percentage, evident in efficacyly is higher than current domesticly with the subject treatment level, easy to use, has no side effect.

The embodiment explanation:

Embodiment one, and the raw materials used and every dose of proportioning of this example is:

Olibanum 7g Myrrha 6g Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 7g

Radix Aconiti Kusnezoffii 3g Rhizoma Arisaematis 7g Rhizoma Pinelliae 7g Borneolum Syntheticum 7g

Natural Calculus Bovis 2g Moschus 2g

Embodiment two, and this routine used base stock and every dose of proportioning are:

Olibanum 5g Myrrha 5g Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5g Radix Aconiti Kusnezoffii 2g

Rhizoma Arisaematis 5g Rhizoma Pinelliae 5g Borneolum Syntheticum 5g natural Calculus Bovis 1g

Moschus 1g Radix Notoginseng 5g Semen Strychni 2g Piper longum 5g

Wherein add Radix Notoginseng have invigorate blood circulation, the effect of cooling blood and relieving pain, the effect that Semen Strychni, Piper longum have detoxification heresy, pain relieving to have one's ideas straightened out, they can further play the effect that promotes and strengthen drug effect.

Embodiment three, and this routine used base stock and every dose of proportioning are:

Olibanum 8g Myrrha 8g Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 8g Radix Aconiti Kusnezoffii 4g

Rhizoma Arisaematis 8g Rhizoma Pinelliae 8g Borneolum Syntheticum 8g natural Calculus Bovis 3g

Moschus 3g Radix Notoginseng 8g Semen Strychni 4g Piper longum 8g

Its processing technology is:

1, gets material by above-mentioned prescription, Radix Notoginseng, Olibanum, Myrrha, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, the Rhizoma Pinelliae, Piper longum are cleaned, dried with clear water, break into the soybean grain size particles with disintegrating machine, broken medicine drained the oil soaked 7～15 days in the pot, every dose of medicinal oil 1500g soaks, Oleum sesami 1000g wherein, one-level Oleum Verniciae fordii 5008.

2, will be placed on the medicine that oil immersion was steeped in the iron pan with 250 ℃ of heating parches, treat the drug particles drying after, it is fried withered with about 300 ℃ in slow fire to put into the oil that soaks it, behind the elimination medicinal residues oil is boiled (400 ℃) and is smelt the Cheng Zhuwei degree that drips.

3, temperature is controlled at 80 ℃, adds fine ground Calculus Bovis, Moschus, Borneolum Syntheticum, stir, be cooled to and solidify.

4, above-mentioned ointment is spread out on the black cloth plaster, the heavy 10g of every subsides medicine.

Usage: with plaster heat launch after, apply ointment or plaster at painful area.Whenever force on and to apply ointment or plaster 5～10 days.

Claims (2)

1, the plaster of applying ointment or plaster of treatment cancer pain is characterized in that: being applied to the raw materials used and weight proportion of ointment on fabricbase or the scytoblastema is:

Olibanum 5～8b Myrrha 5～8b Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5～8b

Radix Aconiti Kusnezoffii 2～4b Rhizoma Arisaematis 5～8b Rhizoma Pinelliae 5～8b

Borneolum Syntheticum 5～8b natural Calculus Bovis 1～3b Moschus 1～3b

Wherein b is Unit Weight part,

Above-mentioned raw materials is processed into the application plaster pharmaceutically dosage form.

2, plaster as claimed in claim 1 is characterized in that: being applied to the raw materials used and weight proportion of every dose on plaster on fabricbase or the scytoblastema is:

Olibanum 7g Myrrha 7g Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 7g

Radix Aconiti Kusnezoffii 3g Rhizoma Arisaematis 7g Rhizoma Pinelliae 7g Borneolum Syntheticum 7g

Natural Calculus Bovis 2g Moschus 2g.