CN105412418A - Traditional Chinese medicine oral decoction for treating cerebrovascular disease - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating cerebrovascular disease, in particular to a traditional Chinese medicine oral decoction for treating cerebrovascular disease made from plant Chinese herbal medicine. It is characterized in that, the raw material medicine that makes active ingredient is according to the following parts by weight: papaya 5-10 grams, earthworm 10-40 grams, angelica 5-10 grams, salvia miltiorrhiza 15-30 grams, musk 0.1-3 grams, Sichuan Dome 5-10g, Leech 5-15g, Centipede 5-10g, Fangfeng 5-10g, Peach Kernel 5-10g, Safflower 5-10g, Millipeda 10-25g, Shichangpu 5-10g gram, 5-10 grams of silkworm, 5-10 grams of red peony root, 10-30 grams of kudzu root, 5-10 grams of cassia seed, 5-15 grams of Polygonum multiflorum, 5-20 grams of tangerine peel, all medicines are compatible to treat cerebrovascular disease, with Anticoagulant, thrombolysis, hemostasis, lipid-lowering, blood vessel expansion, microcirculation improvement and other two-way regulating functions, less side effects, low price, simple prescription, good curative effect.

Description

Oral decoction of traditional Chinese medicine for treating cerebrovascular disease

The invention relates to a medicine for treating cerebrovascular disease, in particular to a traditional Chinese medicine oral decoction for treating cerebrovascular disease made from plant Chinese herbal medicine.

Background technique

Cerebrovascular disease includes cardiovascular disease and cerebrovascular disease. It is due to the deposition of fat and cholesterol on the inner wall of arteries, accompanied by the formation of fibrous tissue and calcification, that is, arteriosclerosis. When this lesion develops to the coronary arteries of the heart, it will form coronary heart disease, including: angina pectoris, myocardial infarction and acute death; symptom. It is a common and frequently-occurring disease that endangers people's health, threatens life, and affects the labor force. Common cerebrovascular diseases can be roughly divided into ischemic stroke and hemorrhagic stroke. Hemorrhagic stroke includes cerebral hemorrhage and subarachnoid hemorrhage; ischemic stroke includes four diseases: cerebral thrombosis, cerebral embolism, lacunar infarction and transient ischemic attack. The annual incidence of cerebrovascular disease is an average of 1.4 million to 2 million people in the world. Orientals are higher than Westerners, especially in Eastern European countries and some countries of the former Soviet Union, ranking first. my country followed closely behind;

At present, the treatment of cerebrovascular diseases in my country generally adopts head acupuncture and drug therapy, but the head acupuncture treatment is often due to inaccurate selection of acupoints, inappropriate timing of treatment, different acupuncture techniques, time of acupuncture, frequency of acupuncture, and time of needle retention. , patients with different conditions, and other factors, the effect will be greatly affected. For patients with fainting needles, this treatment method cannot be implemented; Low, accompanied by side effects, long-term medication leads to adverse reactions in the body.

Contents of the invention

In order to overcome the deficiencies of the existing technology for treating cerebrovascular diseases, the present invention provides a traditional Chinese medicine oral decoction that is effective in curative effect, simple in method, small in side effects, and low in price. The two-way regulating function of thrombus, hemostasis, lipid lowering, expansion of blood vessels, and improvement of microcirculation.

The technical solution adopted by the present invention to solve the technical problems is: a traditional Chinese medicine oral decoction for the treatment of cerebrovascular disease, which is characterized in that, the crude drug made into active ingredients is as follows in parts by weight: 5-10 grams of papaya, ground Dragon 10-40g, Angelica 5-10g, Danshen 15-30g, Musk 0.1-3g, Chuanqiong 5-10g, Leech 5-15g, Centipede 5-10g, Fangfeng 5-10g, Peach Kernel 5-10 grams, 5-10 grams of safflower, 10-25 grams of Cassia Spatholobus, 5-10 grams of Shichangpu, 5-10 grams of silkworm, 5-10 grams of red peony, 10-30 grams of kudzu root, 5- 10 grams, Polygonum multiflorum 5-15 grams, Chenpi 5-20 grams.

Usage: decoct in water, patients can take it twice a day, for patients who are difficult to take traditional Chinese medicine, they can take a small amount and several times in divided doses.

pharmacological effect

Papaya: calms the liver and stomach, removes dampness and relaxes tendons. Control vomiting and diarrhea and tendons turning, arthralgia due to dampness, beriberi, edema, dysentery.

Earthworm: clearing away heat, calming liver, relieving asthma, dredging collaterals. Control high fever and mania, convulsions and convulsions, wind-heat headache, red eyes, hemiplegia due to stroke, wheezing, sore throat, joint pain, bleeding teeth, difficulty urinating, and scrofula. Gills, sores.

Angelica: enriches blood and harmonizes blood, regulates menstruation and relieves pain, moistens dryness and lubricates intestines. Treat irregular menstruation, amenorrhea, abdominal pain, lumps in the abdomen, metrorrhagia; blood deficiency headache, dizziness, impotence; dryness of the intestines, difficulty in defecation, severe diarrhea after redness; carbuncle sores, injuries from falls.

Salvia miltiorrhiza: promoting blood circulation and removing blood stasis, tranquilizing the mind, evacuating pus, relieving pain. Control angina pectoris, irregular menstruation, dysmenorrhea, amenorrhea, metrorrhagia, abdominal pain, accumulation, blood stasis abdominal pain, joint pain, palpitation with fear and insomnia, malignant sore and swelling.

Moschus: resuscitating, warding off dirty, dredging collaterals, dispelling blood stasis. Control apoplexy, syncope due to phlegm, convulsions and epilepsy, middle-evil and dysphoria, sudden pain in trusted subordinates, abdominal mass accumulation, bruises, carbuncle and swollen toxin.

Chuanqiong: promoting qi to relieve depression, treating wind and dampness, promoting blood circulation and relieving pain. Control wind-cold headache, dizziness, hypochondriac pain, abdominal pain, arthralgia due to cold, cramps, amenorrhea, dystocia, postpartum stasis block pain, carbuncle sore. For irregular menstruation, amenorrhea dysmenorrhea, abdominal pain in the abdomen, tingling pain in the chest and hypochondrium, tumbling and swelling pain, headache, rheumatic arthralgia.

Leech: dispelling blood, expelling blood stasis, stimulating menstrual flow. Treatment of blood accumulation, abdominal pain, accumulation, women's amenorrhea, tuberculosis due to dried blood, injury from falls, eye pain, clouding.

Centipede: expelling wind, arresting convulsions, attacking poison, dispelling stagnation. Treatment of stroke, convulsions, epilepsy, tetanus, whooping cough, scrofula, tuberculosis, accumulation of tumors, sores and swelling, wind ringworm, alopecia areata, hemorrhoids, and burns.

Anti-wind: release, expelling wind, eliminating dampness, relieving pain. Control exogenous wind-cold, headache, dizziness, stiff neck, wind-cold-damp arthralgia, arthralgia, extremity contracture, tetanus.

Peach kernel: dispelling blood and removing blood stasis, moistening dryness and smoothing intestines. Control amenorrhea, abdominal pain, febrile disease and blood accumulation, wind arthralgia, malaria, bruises, blood stasis, swelling and pain, dryness of blood and constipation.

Flos Carthami: promoting blood circulation to stimulate menstrual flow, removing blood stasis and relieving pain. Control amenorrhea, lumps in the abdomen, dystocia, stillbirth, postpartum lochia, pain due to blood stasis, carbuncle, injury from falls.

Spatholobus Spatholobus: invigorates blood circulation, relaxes muscles and tendons. Control waist and knee pain, numbness and paralysis, irregular menstruation.

Shichangpu: resuscitating, removing phlegm, regulating qi, promoting blood circulation, dispelling wind, and removing dampness. Treatment of epilepsy, syncope due to phlegm, febrile coma, forgetfulness, air-occlusion deafness, dysphoria, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle and swelling, traumatic injury.

Bombyx mori: expelling wind and relieving spasm, resolving phlegm and resolving stagnation, clearing heat and detoxifying, clearing away heat and dampness. Control heat cough, phlegm and dyspnea, hematemesis, metrorrhagia, belt, traumatic injury, rheumatic pain, sore.

Radix Paeoniae Rubra: promoting blood stasis, relieving pain, cooling blood, detumescence. Control amenorrhea due to stasis of blood, hernia mass accumulation, abdominal pain, hypochondriac pain, epistaxis, bloody dysentery, intestinal wind bleeding, conjunctival congestion, carbuncle.

Radix Puerariae: ascending yang and detoxifying muscles, clearing rash and relieving diarrhea, relieving restlessness and relieving temperature. Treatment of typhoid fever, warm headache, strong neck, restless heat and thirst, diarrhea, dysentery, impervious rash, high blood pressure, angina pectoris, deafness

Cassia seed: liver clearing, eyesight improving, diuresis, laxative. Treat wind-heat red eyes, green blindness, bird eyes, high blood pressure, hepatitis, liver cirrhosis, ascites, and habitual constipation.

Polygonum multiflorum: Tonifies the liver, nourishes the kidney, nourishes blood, and dispels wind. Treatment of liver and kidney yin deficiency, premature graying of hair and beard, blood deficiency, dizziness, weakness of the waist and knees, aching muscles and bones, nocturnal emission, metrorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, intestinal wind, and hemorrhoids. Radix Polygoni Multiflori nourishes liver and kidney, benefits essence and blood, black beard and hair, strengthens muscles and bones; used for vertigo and tinnitus, premature graying of beard and hair, soreness of waist and knees, numbness of limbs, neurasthenia, hyperlipidemia.

Tangerine peel: regulates qi and invigorates the spleen, regulates the middle, dries dampness, and reduces phlegm. Indications for abdominal fullness or pain due to stagnation of spleen and stomach Qi, and indigestion. Chest tightness, abdominal distension, loss of appetite and loose stool in damp turbidity resistance. Cough and asthma caused by phlegm damp blocking the lung.

The beneficial effect of the present invention is that after combining the above-mentioned medicines, it has two-way regulating functions such as anticoagulant, thrombolysis, hemostasis, lipid-lowering, expansion of blood vessels, and improvement of microcirculation in the treatment of cerebrovascular diseases, with few side effects and low price. The formula is simple and the curative effect is good.

Clinical Observation:

Clinical observations included 102 cases of cerebral thrombosis and stroke hemiplegia, including 60 males and 42 females, aged 45-76 years, with an average age of 56-12 (X+S). Patients with cerebral thrombosis (with hemiplegia) who were admitted to the hospital were randomly divided into treatment group and control group according to the sequence. Patient's physical examination CT diagnosis after admission, state of mind, comprehensive functional treatment results are recorded in the observation table, the treatment group takes the oral decoction of the pharmaceutical composition of the present invention, and the matched group uses Lemai Granules, and the curative effect score is issued according to the " Guidelines for Clinical Research of New Drugs of Traditional Chinese Medicine".

The comparison between the curative effect of clinical treatment and the control group is as follows:

The results of clinical observation show that: the oral decoction of traditional Chinese medicine of the present invention has a good curative effect in the recovery period of apoplexy (cerebral thrombosis) of qi deficiency and blood stasis type, and its total effective rate for symptoms and diseases is 98.6%, and the oral decoction can significantly improve the patient's Clinical symptoms can also be improved by CT to a certain extent, and no obvious adverse reactions were found during the observation process.

Animal acute toxicity experiments show that the maximum tolerated dose of this product by mice is >355g/Kg body weight, which is equivalent to about 75 times the equivalent dose of human clinical body surface, and equivalent to about 680 times the equivalent dose of human clinical body weight; The long-term toxicity test showed that: the product 40g/Kg body weight was fed to rats continuously for ten weeks, and it had no effect on the general situation, hematology, blood biochemical indicators, important organ tissues, organ coefficients and histopathological examination of the rats. Abnormal, indicating that the product is safe for oral clinical application at the recommended human dose.

Case example

Zhang, male, 55 years old. Visited on October 2, 2011. The patient felt dizzy three days before seeing a doctor, failed to attract my attention, still insisted on working, and finally fainted at the work post. After being sent to the emergency room, it was found that the patient's mind was not clear, and the right upper and lower limbs were paralyzed. He planned to take the decoction of the invention, one dose a day. After 15 days, the lower limbs began to move, and the upper limbs could be lifted. With the support of family members, he could walk indoors for a short time. Afterwards, continue to take medicinal decoction of the present invention, after 2 months, limb activity function returns to normal fully, consolidates the course for the treatment of one month, follows up a case by regular visits to and does not recur so far.

Li, female, 60 years old. In March 2010, he went to see a doctor. Obese body, often feeling dizzy. When seeing a doctor, the mouth and eyes were crooked, Sheqiang was speechless, the corners of the eyes were tearing, the corners of the mouth were drooling, and the hands and feet were numb and weak. After taking the oral decoction of the present invention for 2 courses of treatment, the corners of the mouth are straightened, and the speech is clear, but still feels dizzy. Consolidation therapy has been given for 3 courses of treatment, and no recurrence has been followed up so far.

detailed description

In order to better understand and implement the present invention, the present invention will be further described below in conjunction with specific examples.

Specific embodiment 1

Weigh 5 grams of papaya, 10 grams of earthworm, 5 grams of angelica, 15 grams of salvia, 0.1 grams of musk, 5 grams of Chuanqiong, 5 grams of leeches, 5 grams of centipedes, 5 grams of wind, 5 grams of peach kernels, 5 grams of safflower, chicken 10 grams of Rhododendron vine, 5 grams of Shichangpu, 5 grams of silkworm, 5 grams of red peony root, 10 grams of kudzu root, 5 grams of cassia seed, 5 grams of Polygonum multiflorum, 5 grams of tangerine peel, wash and dry, soak, decoct. Take it twice, and for patients who are difficult to take traditional Chinese medicine, you can take it in small amounts and multiple times.

Specific embodiment 2

Weigh 5-10 grams of papaya, 10-40 grams of earthworm, 5-10 grams of angelica, 15-30 grams of salvia miltiorrhiza, 0.1-3 grams of musk, 5-10 grams of Chuanqiong, 5-15 grams of leeches, and 5-10 grams of centipedes. gram, 5-10 grams of Fangfeng, 5-10 grams of peach kernel, 5-10 grams of safflower, 10-25 grams of Caulis Spatholobus, 5-10 grams of Shichangpu, 5-10 grams of silkworm, 5-10 grams of red peony, 10-30 grams of kudzu root, 5-10 grams of cassia seed, 5-15 grams of Polygonum multiflorum, 5-20 grams of tangerine peel, wash and dry, soak and decoct. Patients can take it twice a day. For patients who are difficult to take traditional Chinese medicine, you can A small amount of multiple servings.

Specific embodiment 3

Weigh 10 grams of papaya, 40 grams of earthworm, 10 grams of angelica, 30 grams of salvia, 3 grams of musk, 10 grams of Chuanqiong, 15 grams of leech, 10 grams of centipede, 10 grams of wind, 10 grams of peach kernel, 10 grams of safflower, chicken Blood vine 25 grams, Shichangpu 10 grams, silkworm 10 grams, red peony root 10 grams, kudzu root 30 grams, cassia seeds 10 grams, Polygonum multiflorum 15 grams, tangerine peel 20 grams, wash and dry, soak, decoct, patients can divide in one day Take it twice, and for patients who are difficult to take traditional Chinese medicine, you can take it in small amounts and multiple times.

Wash the medicine with water, then soak it in cold water for 20-30 minutes, so that the medicine is completely soaked in water to facilitate the dissolution of active ingredients, and then put the medicine in a casserole, ceramic or crock pot (iron pots are not allowed) and aluminum pot), add water 5-10 times as much as the drug. Or about 2-3 cm higher than the medicine surface. When decocting for the first time, heat it to about 100°C with high heat, then switch to low heat and simmer for 20 minutes, pour the medicinal soup into a container, and decoct for the second time. , but the time can be slightly shorter. After the decoction, mix the two decoctions together and take it. The total amount is 300-500 ml. The patient can take it twice a day. A small amount of multiple servings.

Claims (2)

1. treat a Chinese herbal oral decoction for cerebrovascular, it is characterized in that, the crude drug making effective ingredient by following weight parts is: Fructus Chaenomelis 5-10 gram, Pheretima 10-40 gram, Radix Angelicae Sinensis 5-10 gram, Radix Salviae Miltiorrhizae 15-30 gram, Moschus 0.1-3 gram, Rhizoma Chuanxiong 5-10 gram, Hirudo 5-15 gram, Scolopendra 5-10 gram, Radix Saposhnikoviae 5-10 gram, Semen Persicae 5-10 gram, Flos Carthami 5-10 gram, Caulis Spatholobi 10-25 gram, Rhizoma Acori Graminei 5-10 gram, Bombyx Batryticatus 5-10 gram, Radix Paeoniae Rubra 5-10 gram, Radix Puerariae 10-30 gram, Semen Cassiae 5-10 gram, Radix Polygoni Multiflori 5-15 gram, Pericarpium Citri Reticulatae 5-20 gram.

2. according to claims 1, treat the Chinese herbal oral decoction of cerebrovascular, it is characterized in that, the crude drug making effective ingredient by following weight parts is: Fructus Chaenomelis 8 grams, Pheretima 25 grams, Radix Angelicae Sinensis 8 grams, Radix Salviae Miltiorrhizae 25 grams, 1 gram, Moschus, Rhizoma Chuanxiong 8 grams, Hirudo 10 grams, Scolopendra 8 grams, Radix Saposhnikoviae 8 grams, 8 grams, Semen Persicae, 8 grams, Flos Carthami, Caulis Spatholobi 17 grams, Rhizoma Acori Graminei 8 grams, Bombyx Batryticatus 8 grams, Radix Paeoniae Rubra 8 grams, Radix Puerariae 20 grams, Semen Cassiae 8 grams, Radix Polygoni Multiflori 10 grams, Pericarpium Citri Reticulatae 15 grams.