CN105372803A - Depth of field-increasing microscopic optical system - Google Patents
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Abstract
The invention discloses a depth of field-increasing microscopic optical system comprising a sample stage used for placing samples, a lighting system and a light source which are disposed below the sample stage, a microscopic objective disposed above the sample stage, a tube lens disposed above the microscopic objective, a splitting prism disposed between the microscopic objective and the tube lens or above the tube lens, and at least two imaging elements disposed on the imaging side of the splitting prism, wherein the imaging elements differ in back focal length. According to the invention, the splitting prism is added on the basis of a traditional microscopic optical system, the location of a taken object plant is changed by changing the back focal length of the optical system, and therefore, object planes taken by different imaging elements are in different positions. Under the condition of not affecting the imaging quality, the depth of field is increased, and a high-resolution image of a living body sample or fluid sample can be taken in real time.
Description
Technical field
The present invention relates to optical technical field, particularly relate to a kind of micro optical system increasing the depth of field.
Background technology
In the development process of optical microscope, its function from strength to strength, but due in micro optical system, the enlargement ratio of microcobjective is higher, numerical aperture is larger, and its depth of field is less, and small out of focus will cause track rejection, so in microscopical practical application, the field depth tool expanding imaging system while the image quality keeping imaging system is of great significance.In micro-imaging field now, be more in the research of being carried out improving the microscopic system depth of field by scanning imagery.But scanning imagery method needs system to consume the plenty of time on scanning calculates, and can only be applied in the observation of static sample, cannot observe biopsy sample or fluid sample.In the practical application of fluid cell micro-imaging, need to carry out captured in real-time to cell while meeting the requirement of certain depth of field.
Therefore, prior art has yet to be improved and developed.
Summary of the invention
In view of above-mentioned the deficiencies in the prior art, the object of the present invention is to provide a kind of micro optical system increasing the depth of field, be intended to solve the problem that existing micro optical system cannot ensure image quality and extended depth of field scope simultaneously.
Technical scheme of the present invention is as follows:
Increase a micro optical system for the depth of field, wherein, comprising:
For placing the sample stage of sample;
Be positioned at the illuminator below sample stage and light source;
Be positioned at the microcobjective above sample stage;
Be positioned at the Guan Jing above microcobjective;
Between microcobjective and Guan Jing or the Amici prism be positioned at above Guan Jing;
At least 2 image-forming components being positioned at Amici prism imaging surface, each image-forming component has different rear cut-off distances.
The micro optical system of the described increase depth of field, wherein, described Amici prism and Guan Jingjun are set to 1, Amici prism is positioned at above Guan Jing, described image-forming component is 2, one of them image-forming component is positioned at standard image planes, and the distance of object plane and standard object plane captured by another image-forming component is a depth of field.
The micro optical system of the described increase depth of field, wherein, described Amici prism is set to 1, and described Amici prism is positioned at above microcobjective; Described Guan Jing is set to 2, and one of them Guan Jing is positioned at above Amici prism, and another Guan Jing is positioned at the side of point light direction of Amici prism; Described image-forming component is 2, and one of them image-forming component is positioned at standard image planes, and the distance of object plane and standard object plane captured by another image-forming component is a depth of field.
The micro optical system of the described increase depth of field, wherein, described Amici prism is set to 2, and is arranged side by side along illuminator light direction and is all arranged on above microcobjective; Described image-forming component is set to 3, and one of them is positioned at standard image planes, and the distance of a captured object plane and standard object plane is a depth of field, and the distance of object plane captured by another and standard object plane is two depth of field.
The micro optical system of the described increase depth of field, wherein, the splitting ratio of described Amici prism is 50%:50%.
The micro optical system of the described increase depth of field, wherein, described Guan Jing comprises 1 cemented doublet and 1 meniscus lens.
The micro optical system of the described increase depth of field, wherein, the enlargement ratio of described micro optical system is 20 times.
The micro optical system of the described increase depth of field, wherein, described micro optical system also connects an image processing module, and for the image captured by different image-forming component being carried out synthesis process, the characteristic information extracted in each image is reconstructed.
The micro optical system of the described increase depth of field, wherein, described illuminator comprises collecting lens group and condenser group.
The micro optical system of the described increase depth of field, wherein, described image-forming component is CCD or CMOS photo-sensitive cell.
Beneficial effect: the present invention, on traditional micro optical system basis, adds Amici prism, changes captured object plane position by the mode changing optical system rear cut-off distance, and the object plane position captured by so different image-forming component is different.Present invention achieves and realize increasing the depth of field and the function of the high-definition picture of captured in real-time biopsy sample or fluid sample when not affecting image quality.
Accompanying drawing explanation
Fig. 1 is the principle schematic of micro optical system of the present invention.
Fig. 2 is the structural representation of micro optical system embodiment one of the present invention.
The cell image of Fig. 3 a to Fig. 3 c captured by embodiment one.
Fig. 4 is the structural representation of micro optical system embodiment two of the present invention.
Fig. 5 is the structural representation of micro optical system embodiment three of the present invention.
Embodiment
The invention provides a kind of micro optical system increasing the depth of field, for making object of the present invention, technical scheme and effect clearly, clearly, the present invention is described in more detail below.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
A kind of micro optical system increasing the depth of field provided by the present invention, it comprises:
For placing the sample stage of sample;
Be positioned at the illuminator below sample stage and light source; Described illuminator can be kohler's illumination, comprises collecting lens group and condenser group.Light source is positioned at below illuminator.
Be positioned at the microcobjective above sample stage;
Be positioned at the Guan Jing above microcobjective; Described Guan Jing comprises 1 cemented doublet and 1 meniscus lens.The enlargement ratio of described micro optical system is 20 times.Such as, the focal length of microcobjective is the focal length of 4.5mm, Guan Jing is 90mm, and enlargement ratio is pipe mirror focal length and the ratio of microcobjective focal length.
Between microcobjective and Guan Jing or the Amici prism be positioned at above Guan Jing; The splitting ratio of described Amici prism is preferably 50%:50%.
At least 2 image-forming components being positioned at Amici prism imaging surface, each image-forming component has different rear cut-off distances.Image-forming component can be CCD or CMOS photo-sensitive cell.
Microcobjective of the present invention is general microcobjective, and its emergent ray is class directional light, after increase Amici prism, by the light splitting of Amici prism, obtains at least 2 imaging surfaces, receives respectively with image-forming component.And different image-forming component has different rear cut-off distances at micro optical system, rear cut-off distance refers to the distance of the last one side of optical microscope system and imaging surface.
In optical microscope system, the object plane position that different image planes positions is corresponding different, the skew of image planes position can make the object plane of system actual photographed and theoretical object plane have a minor shifts amount.Through image procossing, captured image is merged again, the micro-image of all objects blur-free imaging in all image-forming components each actual object plane field depth corresponding respectively can be obtained, and improve the sharpness of image, thus increase the depth of field of microscopic system when not affecting image quality.
Fig. 1 is the principle schematic of micro optical system of the present invention.In figure, O is standard object plane, I is standard image planes, the side-play amount that dl is the actual image planes and standard image planes that are positioned at the image-forming component in I ' face, the actual object plane position of O ' captured by this image-forming component, ds is captured actual object plane position and the side-play amount of standard object plane.L is the rear cut-off distance difference of two image-forming components with maximum rear cut-off distance difference, and S is the maximum object plane side-play amount of its correspondence.
The vertical axle enlargement ratio β of micro optical system of the present invention is:
In formula, f'
guan Jing: pipe mirror focal length, f'
object lens: microcobjective focal length.
Corresponding relation between the axial enlargement ratio α and vertical axle enlargement ratio β of micro optical system is:
α＝β
2
According to above-mentioned formula, the corresponding relation between the side-play amount dl of actual image planes and standard image planes and the side-play amount ds of actual object plane and standard object plane is:
dl＝ds·α
Therefore the maximum object plane interval S captured by system is:
S＝L/α
Wherein, L: the difference with the rear cut-off distance of two image-forming components of maximum rear cut-off distance difference.
Before known light splitting, the depth of field DF of micro optical system is:
N in formula: micro optical system place spatial refractive index;
E: the picture dot size of image-forming component;
NA: numerical aperture;
M: overall amplification;
λ: optical wavelength.
Micro optical system of the present invention adds multiple image-forming component, multiple image planes are received, object plane corresponding to each image planes can blur-free imaging in field depth, therefore the depth of field of micro optical system of the present invention for there is minimum rear cut-off distance image-forming component corresponding to the rear depth of field of object plane to the distance of the depth of field before the object plane corresponding to the image-forming component with maximum rear cut-off distance, depth of field sum after the maximum object plane spacing namely captured by system and a front depth of field and.The depth of field of optical system is the front depth of field and rear depth of field sum again, therefore the actual depth of field DF ' of micro optical system of the present invention can be expressed as:
DF'＝DF+S
Multiple image-forming component can carry out the reception of image simultaneously, coordinates, reach good synchronism in practical operation with electrical equipment.Described micro optical system also connects an image processing module, and for the image captured by different image-forming component being carried out synthesis process, the characteristic information extracted in each image is reconstructed.Namely captured multiple image is merged, denoising, the process such as feature extraction and reconstruct, extract the advantageous information in each picture to greatest extent, reconstruct formation one width picture, reach the object increasing the depth of field, with reference to image processing techniques of the prior art, can repeat no more herein about this partial content.
In the present invention, microcobjective is general microcobjective, can change.Such as use has different enlargement ratio, numerical aperture, focal length, resolution and the isoparametric microcobjective of covering difference can make micro optical system of the present invention have the characteristics such as different enlargement ratio, numerical aperture, focal length, resolution and covering difference.
Below by specific embodiment, the present invention will be described in detail.
Specific embodiments of the invention one, as shown in Figure 2.Micro optical system specifically comprises: light source 1, illuminator 2, sample stage 3, microcobjective 4, pipe mirror 5, Amici prism 6 and image-forming component 7.Described Amici prism 6 and pipe mirror 5 are all set to 1, and Amici prism 6 is positioned at above pipe mirror 5, and described image-forming component 7 is 2, and one of them image-forming component is positioned at standard image planes, and the distance of object plane and standard object plane captured by another image-forming component is a depth of field.
Light source 1 is wherein positioned at below illuminator.Illuminator is kohler's illumination system, comprises collecting lens group 8 and is positioned at the condenser group 9 of collecting lens group 8 with top.Sample stage 3 is positioned at above illuminator 2, is used for placing sample.
Microcobjective 4 is positioned at above sample stage 3, and the focal length of microcobjective 4 is 4.5mm.Pipe mirror 5 is positioned at above microcobjective 4, and pipe mirror 5 comprises a cemented doublet and a meniscus lens, and the focal length of pipe mirror 5 is 90mm.The enlargement ratio of whole micro optical system is 20 times.The splitting ratio of Amici prism 6 is 50%:50%.
Two image-forming components are taken simultaneously, through the cooperation of electrical equipment, make the actual photographed interval of two image-forming components reach musec order.Again two captured width images are merged, denoising, feature extraction and reconstruction processing, image definition is significantly improved, sample standard deviation blur-free imaging in the field depth of the actual photographed object plane corresponding to two image-forming components, thus the increasing of the system depth of field is twice.
The cell image of Fig. 3 a to Fig. 3 c captured by the micro optical system of embodiment one.Wherein Fig. 3 a image that image obtains after image-fused-reconstruction captured by two image-forming components, Fig. 3 b is wherein image captured by an image-forming component, and Fig. 3 c is image captured by another image-forming component.Wherein, details 1 in Fig. 3 b, 2 can clearly differentiate, and details 3 cannot be differentiated.In Fig. 3 c, details 1,2 image blurs, details 3 can clearly be differentiated.It can thus be appreciated that details 1,2 and details 3 are in Different Plane, and not in a field depth.After the automated graphics process of present system, in Fig. 3 a obtained, details 1,2,3 all clear resolutions of energy, thus the known system depth of field of the present invention obviously increases.
Specific embodiments of the invention two, as shown in Figure 4.Micro optical system comprises equally: light source 1, illuminator 2, sample 3, microcobjective 4, Amici prism 5, pipe mirror 6 and image-forming component 7.
Described Amici prism 5 is set to 1, and described Amici prism 5 is positioned at above microcobjective 4; Described pipe mirror 6 is set to 2, and one of them pipe mirror 6 (the first pipe mirror) is positioned at above Amici prism 5, and another pipe mirror 6 (the second pipe mirror) is positioned at the side of point light direction of Amici prism 5; Described image-forming component 7 is 2, a top being positioned at the first pipe mirror, a side being positioned at the second pipe mirror.One of them image-forming component is positioned at standard image planes, and the distance of object plane and standard object plane captured by another image-forming component is a depth of field.
The imaging beam received is divided into two bundles by Amici prism 5, respectively through two pipe mirrors 6, is imaged on the receiving plane of two image-forming components 7.Two image-forming components 7 are taken simultaneously, through the cooperation of electrical equipment, make the actual photographed interval of two image-forming components 7 reach musec order.Again two captured width images are merged, denoising, feature extraction and reconstruction processing, image definition is significantly improved, sample standard deviation blur-free imaging in the field depth of the actual photographed object plane corresponding to two image-forming components 7, thus the increasing of the system depth of field is twice.
Outgoing beam due to microcobjective in micro optical system is class directional light, therefore is placed in by Amici prism between microcobjective 4 and pipe mirror 6 and does not almost affect image quality.Therefore, can on the basis of former micro optical system, without the need to redesigning pipe mirror structure, only need increase by 1 Amici prism, 5,1 pipe mirror 6 and 1 image-forming component 7 and just can reach the depth of field is expanded twice effect.The present embodiment can design processes simplified, realizes the depth of field expansion of any existing micro optical system.
Specific embodiments of the invention three, it is the micro optical system containing three tunnel light splitting.In the present embodiment, described Amici prism is set to 2, and is arranged side by side along illuminator light direction and is all arranged on above microcobjective; Described image-forming component is set to 3, as shown in Figure 5, one of them image-forming component S1 is positioned at standard image planes I1, object plane captured by an image-forming component S2 and the distance of standard object plane are a depth of field (its actual image planes are a corresponding depth of field with the distance of standard image planes I2), and object plane captured by another image-forming component S3 and the distance of standard object plane are two depth of field (its actual image planes are corresponding two depth of field with the distance of standard image planes I3).Make 3 image-forming components simultaneously to imaging samples in practical operation, then merge three width images, reconstruct, obtain piece image, now the depth of field of system is 3 times of the former optical system depth of field.
Micro optical system of the present invention according to required depth of field expanded scope determination light splitting optical path number, and can determine the difference of the rear cut-off distance between each image-forming component in the application according to formula.
Extended depth of field method by carrying out image co-registration after Amici prism light splitting again in the present invention is not only applicable to micro optical system, is equally applicable to other optical imaging systems such as telescopic system, illuminator, optical projection system.
The invention has the advantages that: Guan Jingjing group only needs three eyeglasses, structure is simple, and cost is low; Replaceable general object lens, set of system can meet the micro-imaging demand of different enlargement ratio, different resolution, different operating distance; Without the need to scanning, consuming time short, can captured in real-time be carried out; The obvious increase optical system depth of field; Do not affect microscopic system image quality; There is very high imaging definition.
Should be understood that, application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (10)
1. increase a micro optical system for the depth of field, it is characterized in that, comprising:
For placing the sample stage of sample;
Be positioned at the illuminator below sample stage and light source;
Be positioned at the microcobjective above sample stage;
Be positioned at the Guan Jing above microcobjective;
Between microcobjective and Guan Jing or the Amici prism be positioned at above Guan Jing;
At least 2 image-forming components being positioned at Amici prism imaging surface, each image-forming component has different rear cut-off distances.
2. the micro optical system of the increase depth of field according to claim 1, it is characterized in that, described Amici prism and Guan Jingjun are set to 1, Amici prism is positioned at above Guan Jing, described image-forming component is 2, one of them image-forming component is positioned at standard image planes, and the distance of object plane and standard object plane captured by another image-forming component is a depth of field.
3. the micro optical system of the increase depth of field according to claim 1, is characterized in that, described Amici prism is set to 1, and described Amici prism is positioned at above microcobjective; Described Guan Jing is set to 2, and one of them Guan Jing is positioned at above Amici prism, and another Guan Jing is positioned at the side of point light direction of Amici prism; Described image-forming component is 2, and one of them image-forming component is positioned at standard image planes, and the distance of object plane and standard object plane captured by another image-forming component is a depth of field.
4. the micro optical system of the increase depth of field according to claim 1, is characterized in that, described Amici prism is set to 2, and is arranged side by side along illuminator light direction and is all arranged on above microcobjective; Described image-forming component is set to 3, and one of them is positioned at standard image planes, and the distance of a captured object plane and standard object plane is a depth of field, and the distance of object plane captured by another and standard object plane is two depth of field.
5. the micro optical system of the increase depth of field according to claim 1, is characterized in that, the splitting ratio of described Amici prism is 50%:50%.
6. the micro optical system of the increase depth of field according to claim 1, is characterized in that, described Guan Jing comprises 1 cemented doublet and 1 meniscus lens.
7. the micro optical system of the increase depth of field according to claim 1, is characterized in that, the enlargement ratio of described micro optical system is 20 times.
8. the micro optical system of the increase depth of field according to claim 1, it is characterized in that, described micro optical system also connects an image processing module, and for the image captured by different image-forming component being carried out synthesis process, the characteristic information extracted in each image is reconstructed.
9. the micro optical system of the increase depth of field according to claim 1, is characterized in that, described illuminator comprises collecting lens group and condenser group.
10. the micro optical system of the increase depth of field according to claim 1, is characterized in that, described image-forming component is CCD or CMOS photo-sensitive cell.
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| CN109491176A (en) * | 2019-01-09 | 2019-03-19 | 凌云光技术集团有限责任公司 | Big depth field imaging system and method based on prismatic decomposition |
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Address after: 130103 No. 3333 livable Road, hi tech Development Zone, Jilin, Changchun Applicant after: Medical Polytron Technologies Inc Address before: 130103 No. 3333 livable Road, hi tech Development Zone, Jilin, Changchun Applicant before: Changchun Dirui Medical Technology Co., Ltd. |
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Application publication date: 20160302 |