CN105327183A

CN105327183A - Medicine for treating bovine pulmonary emphysema and preparation method thereof

Info

Publication number: CN105327183A
Application number: CN201510878223.2A
Authority: CN
Inventors: 黄河; 李鑫
Original assignee: Shandong New Hope Liuhe Group Co Ltd
Current assignee: Shandong New Hope Liuhe Group Co Ltd
Priority date: 2015-12-04
Filing date: 2015-12-04
Publication date: 2016-02-17

Abstract

The invention discloses medicine for treating bovine pulmonary emphysema and a preparation method thereof. The medicine comprises the following raw herbal materials including radix cudramiae, buttonbush roots, astilbe chinensis, fructus aristolochiae, chrysopogon aciculatus, adenophora trachelioides maxim, cortex lycii radicis, ginkgo, flos farfarae, blackberry lily, indigo naturalis, tabasheer, sargentgloryvine stems, fomes officinalis ames, semen lepidii, inula flower, radix asteris, folium eriobotryae, folia perillae acutae, semen armeniacae amarae, schisandra chinensis, rhizoma anemarrhenae, ipomoea cairica, toricellia angulata, toosendan fruits, lumbricus, bignoniad roots, oldenlandia diffusa and humifuse euphorbia herbs. The medicine has the main effects of clearing away heat to eliminating phlegm, lowering the adverse flow of qi and relieving asthma, has the subsidiary effects of tonifying the spleen and nourishing yin, treats bovine pulmonary emphysema and can enhance the immunity, the curative effect is definite, the course of treatment is short, the curative effect is good, no drug resistance exists, no medicine residue exists, the cost is low, the price is low, the state of an illness can be effectively controlled, and relapse does not occur easily.

Description

One is used for the treatment of emophysematous medicine of cattle and preparation method thereof

Technical field

The present invention relates to field of veterinary, particularly relate to one and be used for the treatment of emophysematous medicine of cattle and preparation method thereof.

Background technology

Pulmonis Bovis seu Bubali edema due to disorder of QI is because alveolar is full of excess air and overdistension, makes the volumetric expansion of lung, breaks with alveolar wall.Common are alveolar emphysema and interstitial lung edema due to disorder of QI, is the most common a kind of clinical pathology change of milch cow pulmonary disease, clinical in dyspnea, expiration duration and firmly for feature.Divide acute and chronic two kinds.

The cause of disease

Emphysema are a kind of important infringements in typical interstitial pneumonia, parasitic pneumonia and the pulmonary edema that caused by acute allergic reaction.Its reason has following all: feedstuff flip-flop, after search for food in a large number grass, Radix Brassicae rapae, Caulis et Folium Brassicae capitatae, alfalfa and Brassica campestris L; Tryptophan of feeding changes heteroauxing in cud, and decarboxylation forms 3-methylindole, enters blood and presents toxic action to alveolar epithelial cells, can cause emphysema through rumenal mucosa absorption.Mew air is dirty, and the air of suction is often containing potentiality excitor substance; Feedstuff is mouldy, rotten, and too much containing dust, the little many pityrosporion ovales contained by it, Aspergillus fumigatus all can excite emphysema.The sick cattle that virus and bacterial disease cause toxenia to levy as escherichia coli mastitis has emphysema; Bovine epizootic fever cattle has emphysema.Traumatic reticulitis caused by metallic foreign body, then stabs lungs when causing pulmonary abscess, can cause emphysema.Some feedstuff toxin are poisoned lung, time as poisoning in cattle sweet potato melasma, have serious emphysema.Toxic gas, as the flue gas suction etc. of emerging when chlorine poisoning, metal solder, can cause emphysema.

Pathogeny

Pulmonary parenchyma supporting tissue and Elastic tissue overextension are the bases of alveolar overdistension.Various paathogenic factor directly acts on body, causes alveolar tissue and follows the string; Bronchospasm and bronchus and bronchiolitis make airway obstruction, but air still enters alveolar, accumulation cause alveolar to expand by passage therebetween, because alveolar elasticity reduces, is subject to the pressure of expanding gas and breaks.When alveolar is because compressibility atrophy and lung connective tissue are by air expansion, then cause interstitial lung edema due to disorder of QI, this is most commonly in cattle.Lung tissue elastic force reduces, alveolar ectasia, and will cause the accumulation of the complete and carbon dioxide of lung aerofluxus, add to blood capillary blood flow under emphysema tissue compression and slow down, therefore in lung, gas and extraneous exchange area reduce, and cause the aerobic deficiency of body.In order to meet the need of oxygen, under the adjustment of nervus centralis, causing vicarious respiration and deepening to accelerate, so just exacerbating the formation of chronic emphysema.During emphysema, due to Pulmonic thrombosis, cause that right ventricle is expanded, the storage of exhaustion and carbon dioxide is stayed, make disease cattle generation acidosis.

Clinical symptoms

Mild symptoms is paid attention to emphysema degree and determines.Can asymptomatic or only feel to breathe hard when cattle Niu Yundong in early days.Along with emphysema progress, dyspnea degree increases the weight of thereupon, even so that slightly movable rest completely time still feel and breathing hard.Trouble cattle feels weak, weight loss, loss of appetite, upper abdomen distension.With symptoms such as cough, expectorations, typical emphysema person's thorax anteroposterior diameter increases, and in barrel chest, respiratory movement weakens, vocal fremitus weakens, percussion hyperresonant note, and border of cardiac dullness reduces, and liver dullness circle moves down, respiratory murmur lowers, and sometimes can hear dry, moist rales, hear sounds is far low.

Acute emphysema break out, and sick cattle spirit is depressed, and poor appetite is to absolutely useless, shed tears, rhinorrhea is slurry property or purulence, uneasiness of standing, be reluctant sleepingly, visual mucosa cyanosis, body temperature majority is increased to 40.5 DEG C, flows out white foam thing in mouth, milk yield die-offs, heartbeat increases to 100-160 time per minute, and cardiac rhythm is uneven, muffled heart sounds.Classical symptom is dyspnea, and frequency of respiration is increased to 40-80 time per minute, and minority reaches more than 100 times, asthma, abdominal part is agitated, and expansion is opened in nostril, raise the head and stretch neck, hang one's tongue out in astonishment, tongue is mulberry, and chest percussion can be tympanitic resonance, auscultation of lung has friction sound and sound of vomiting sound, occur edema due to disorder of QI in both sides, back are subcutaneous, palpation is crepitation, and edema due to disorder of QI can spread to breast cervical region, shoulder and head.

Diagnosis

Can clarify a diagnosis according to medical history, health check-up, X-ray examination and lung function tests.X-ray inspection shows as thoracic cavity anteroposterior diameter and increases, breastbone prolapse, and retrosternal space is broadening, and diaphragm is low flat, and lung marking reduces, and lung field transmittance increases, vertical heart, pulmonary artery and Main Branches broadening, peripheral blood vessel is tiny.Lung function tests shows as residual gas, total lung capacity increases, residual gas/total lung capacity ratio increases, FEV1/FVC significantly reduces, diffusion lowers.

Treatment

Specific short be there is no to emphysema.Be secondary to the emphysema of infectious pneumonias, effectively treat primary lesion, with the recovery from illness of protopathy, emphysema will disappear usually voluntarily.Concrete Therapeutic Method: oxygen therapy when severe depletion of oxygen and threat to life time, should cure by oxygen therapy.Oxygen therapy speed should control to be advisable at 5-61/min, continues 3h, and when just curing by oxygen therapy, speed is first slow, is generally 3-41/min, after accelerate gradually.Diuresis emphysema are often with pulmonary edema, and for alleviating pulmonary edema, if body fluid conditions is good, can use furosemide, dosage is 5-1.0mg/kg or 25-50mg/45kg body weight, every day 1 or 2 intramuscular injection.Remove bronchospasm, alleviate dyspnea atropine 0.05mg/kg body weight, an intramuscular injection, every day twice.Antiinflammatory, antiallergic can use dexamethasone 10-20mg, and a muscle or intravenous injection, once a day, be used in conjunction 3d.Antiinflammatory, antibacterial, prevent secondary infection from can select broad-spectrum antibiotic therapy 5-7d.

There is its defect in the treatment of doctor trained in Western medicine, occurs more toxic and side effects, there is no special effective therapy at present to primary disease, and side effect is large, and therapeutic effect is undesirable.

Chinese medicine pulmonis Bovis seu Bubali edema due to disorder of QI energy Comprehensive Treatment, treating both the principal and secondary aspects of a disease, can strengthen its resistivity, the course for the treatment of is shorter, and curative effect is better, has no drug resistance, drug residue free, and cost price is cheap, can effective symptom management, not easily recurs after healing.

Summary of the invention

Technical problem to be solved by this invention is to provide one to be used for the treatment of the emophysematous medicine of cattle, can overcome the various defects of Chinese medicine of the prior art and Western medicine, have eliminate the phlegm based on heat clearing away, lowering the adverse-rising QI to subdue asthma, hold concurrently with the effect holding up spleen yin nourishing, its resistivity can be strengthened, and determined curative effect, the course for the treatment of is shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, and cost price is cheap, can effective symptom management, not easily recur after healing.

In order to realize foregoing invention object, the invention provides one and be used for the treatment of the emophysematous medicine of cattle, described medicine comprises following raw medicinal material: Radix Cudraniae, Radix Cephalanthi Occidentalis, Herba astilbes chinensis, Fructus Aristolochiae, Radix et Rhizoma Dispori Cantoniensis, Radix Adenophorae Trachelioidis, Cortex Lycii, Semen Ginkgo, Flos Farfarae, Rhizoma Belamcandae, Indigo Naturalis, Concretio Silicea Bambusae, Caulis Sargentodoxae, Fructificatio Fomitopsis Officinalis, Semen Lepidii (Semen Descurainiae), Flos Inulae, Radix Asteris, Folium Eriobotryae, Folium Perillae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, the Rhizoma Anemarrhenae, Radix seu Herba Tetrastigmatis Hypoglauci, Radix Ampelopsis delavayanae, Fructus Toosendan, Pheretima, Radix campsis, Herba Hedyotidis Diffusae and Herba Euphorbiae Humifusae.

In described medicine, the parts by weight of each raw medicinal material can be preferably: Radix Cudraniae 10-15 part, Radix Cephalanthi Occidentalis 16-25 part, Herba astilbes chinensis 11-18 part, Fructus Aristolochiae 15-24 part, Radix et Rhizoma Dispori Cantoniensis 23-28 part, Radix Adenophorae Trachelioidis 10-16 part, Cortex Lycii 17-26 part, Semen Ginkgo 8-13 part, Flos Farfarae 14-25 part, Rhizoma Belamcandae 10-16 part, Indigo Naturalis 20-26 part, Concretio Silicea Bambusae 10-18 part, Caulis Sargentodoxae 11-17 part, Fructificatio Fomitopsis Officinalis 20-26 part, Semen Lepidii (Semen Descurainiae) 11-18 part, Flos Inulae 15-25 part, Radix Asteris 16-28 part, Folium Eriobotryae 15-27 part, Folium Perillae 13-18 part, Semen Armeniacae Amarum 6-10 part, Fructus Schisandrae Chinensis 12-18 part, Rhizoma Anemarrhenae 20-26 part, Radix seu Herba Tetrastigmatis Hypoglauci 11-16 part, Radix Ampelopsis delavayanae 10-19 part, Fructus Toosendan 5-9 part, Pheretima 13-18 part, Radix campsis 20-25 part, Herba Hedyotidis Diffusae 15-22 part and Herba Euphorbiae Humifusae 20-26 part.

In described medicine, the parts by weight of each raw medicinal material also can be preferably: Radix Cudraniae 13 parts, Radix Cephalanthi Occidentalis 21 parts, Herba astilbes chinensis 15 parts, Fructus Aristolochiae 19 parts, Radix et Rhizoma Dispori Cantoniensis 25 parts, Radix Adenophorae Trachelioidis 13 parts, Cortex Lycii 21 parts, Semen Ginkgo 11 parts, Flos Farfarae 18 parts, Rhizoma Belamcandae 15 parts, Indigo Naturalis 22 parts, Concretio Silicea Bambusae 17 parts, Caulis Sargentodoxae 15 parts, Fructificatio Fomitopsis Officinalis 23 parts, Semen Lepidii (Semen Descurainiae) 16 parts, Flos Inulae 19 parts, Radix Asteris 23 parts, Folium Eriobotryae 25 parts, Folium Perillae 16 parts, Semen Armeniacae Amarum 8 parts, Fructus Schisandrae Chinensis 13 parts, the Rhizoma Anemarrhenae 21 parts, Radix seu Herba Tetrastigmatis Hypoglauci 12 parts, Radix Ampelopsis delavayanae 14 parts, Fructus Toosendan 7 parts, Pheretima 14 parts, Radix campsis 22 parts, Herba Hedyotidis Diffusae 18 parts and Herba Euphorbiae Humifusae 21 parts.

Preferably, described medicine also comprises the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Semen Alpiniae Katsumadai, Radix Et Rhizoma Nardostachyos and Radix Glycyrrhizae.

In described medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Cudraniae 10-15 part, Radix Cephalanthi Occidentalis 16-25 part, Herba astilbes chinensis 11-18 part, Fructus Aristolochiae 15-24 part, Radix et Rhizoma Dispori Cantoniensis 23-28 part, Radix Adenophorae Trachelioidis 10-16 part, Cortex Lycii 17-26 part, Semen Ginkgo 8-13 part, Flos Farfarae 14-25 part, Rhizoma Belamcandae 10-16 part, Indigo Naturalis 20-26 part, Concretio Silicea Bambusae 10-18 part, Caulis Sargentodoxae 11-17 part, Fructificatio Fomitopsis Officinalis 20-26 part, Semen Lepidii (Semen Descurainiae) 11-18 part, Flos Inulae 15-25 part, Radix Asteris 16-28 part, Folium Eriobotryae 15-27 part, Folium Perillae 13-18 part, Semen Armeniacae Amarum 6-10 part, Fructus Schisandrae Chinensis 12-18 part, Rhizoma Anemarrhenae 20-26 part, Radix seu Herba Tetrastigmatis Hypoglauci 11-16 part, Radix Ampelopsis delavayanae 10-19 part, Fructus Toosendan 5-9 part, Pheretima 13-18 part, Radix campsis 20-25 part, Herba Hedyotidis Diffusae 15-22 part, Herba Euphorbiae Humifusae 20-26 part, Rhizoma Atractylodis Macrocephalae 13-19 part, Fructus Amomi 10-18 part, Semen Alpiniae Katsumadai 15-22 part, Radix Et Rhizoma Nardostachyos 10-16 part and Radix Glycyrrhizae 15-28 part.

In described medicine, the parts by weight of each raw medicinal material also can be preferably: Radix Cudraniae 13 parts, Radix Cephalanthi Occidentalis 21 parts, Herba astilbes chinensis 15 parts, Fructus Aristolochiae 19 parts, Radix et Rhizoma Dispori Cantoniensis 25 parts, Radix Adenophorae Trachelioidis 13 parts, Cortex Lycii 21 parts, Semen Ginkgo 11 parts, Flos Farfarae 18 parts, Rhizoma Belamcandae 15 parts, Indigo Naturalis 22 parts, Concretio Silicea Bambusae 17 parts, Caulis Sargentodoxae 15 parts, Fructificatio Fomitopsis Officinalis 23 parts, Semen Lepidii (Semen Descurainiae) 16 parts, Flos Inulae 19 parts, Radix Asteris 23 parts, Folium Eriobotryae 25 parts, Folium Perillae 16 parts, Semen Armeniacae Amarum 8 parts, Fructus Schisandrae Chinensis 13 parts, the Rhizoma Anemarrhenae 21 parts, Radix seu Herba Tetrastigmatis Hypoglauci 12 parts, Radix Ampelopsis delavayanae 14 parts, Fructus Toosendan 7 parts, Pheretima 14 parts, Radix campsis 22 parts, Herba Hedyotidis Diffusae 18 parts, Herba Euphorbiae Humifusae 21 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Amomi 14 parts, Semen Alpiniae Katsumadai 19 parts, Radix Et Rhizoma Nardostachyos 13 parts and 23 parts, Radix Glycyrrhizae.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method being used for the treatment of the emophysematous medicine of cattle, and when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method being used for the treatment of the emophysematous medicine of cattle, and when the dosage form of described medicine is powder, its preparation method comprises the following steps:

The first step, Radix Cudraniae, Fructus Aristolochiae, Radix et Rhizoma Dispori Cantoniensis, Flos Farfarae, Concretio Silicea Bambusae, Caulis Sargentodoxae, Fructificatio Fomitopsis Officinalis, Semen Lepidii (Semen Descurainiae), Radix campsis and Herba Euphorbiae Humifusae are mixed in described ratio, with being the dissolve with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Cephalanthi Occidentalis, Radix Adenophorae Trachelioidis, Cortex Lycii, Rhizoma Belamcandae, Flos Inulae, Radix Asteris, Folium Eriobotryae and Folium Perillae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The beneficial effect that embodiment of the present invention technical scheme is brought is: medicine of the present invention eliminates the phlegm based on heat clearing away, lowering the adverse-rising QI to subdue asthma, hold concurrently to hold up spleen yin nourishing, treatment pulmonis Bovis seu Bubali edema due to disorder of QI, can strengthen its resistivity, and determined curative effect, the course for the treatment of is shorter, and curative effect is better, has no drug resistance, drug residue free, cost price is cheap, can effective symptom management, not easily recurs after healing.

Detailed description of the invention

Medicine of the present invention eliminates the phlegm based on heat clearing away, lowering the adverse-rising QI to subdue asthma, hold concurrently to hold up spleen yin nourishing, provide one and be used for the treatment of pulmonis Bovis seu Bubali edema due to disorder of QI medicine, comprise following raw medicinal material: Radix Cudraniae, Radix Cephalanthi Occidentalis, Herba astilbes chinensis, Fructus Aristolochiae, Radix et Rhizoma Dispori Cantoniensis, Radix Adenophorae Trachelioidis, Cortex Lycii, Semen Ginkgo, Flos Farfarae, Rhizoma Belamcandae, Indigo Naturalis, Concretio Silicea Bambusae, Caulis Sargentodoxae, Fructificatio Fomitopsis Officinalis, Semen Lepidii (Semen Descurainiae), Flos Inulae, Radix Asteris, Folium Eriobotryae, Folium Perillae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, the Rhizoma Anemarrhenae, Radix seu Herba Tetrastigmatis Hypoglauci, Radix Ampelopsis delavayanae, Fructus Toosendan, Pheretima, Radix campsis, Herba Hedyotidis Diffusae and Herba Euphorbiae Humifusae.Preferably, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Semen Alpiniae Katsumadai, Radix Et Rhizoma Nardostachyos and Radix Glycyrrhizae.

Wherein, Radix Cudraniae, Radix Cephalanthi Occidentalis, Herba astilbes chinensis, Fructus Aristolochiae, Radix et Rhizoma Dispori Cantoniensis, Radix Adenophorae Trachelioidis, Cortex Lycii, Semen Ginkgo, Flos Farfarae, Rhizoma Belamcandae, Indigo Naturalis, Concretio Silicea Bambusae, Caulis Sargentodoxae heat clearing away are eliminated the phlegm; Fructificatio Fomitopsis Officinalis, Semen Lepidii (Semen Descurainiae), Flos Inulae, Radix Asteris, Folium Eriobotryae, Folium Perillae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, Rhizoma Anemarrhenae lowering the adverse-rising QI to subdue asthma; Radix seu Herba Tetrastigmatis Hypoglauci, Radix Ampelopsis delavayanae, Fructus Toosendan, Pheretima, Radix campsis dredging collateral are invigorated blood circulation; Herba Hedyotidis Diffusae, Herba Euphorbiae Humifusae removing pathogenic heat from blood and toxic substance from the body; Semen Ginkgo, Flos Farfarae, Rhizoma Belamcandae, Indigo Naturalis, Folium Perillae, Semen Armeniacae Amarum dispersing and lowering lung-QI; Spleen yin nourishing held up by the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Semen Alpiniae Katsumadai, Radix Et Rhizoma Nardostachyos; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, invigorating the spleen and benefiting QI.Make a general survey of full side, compatibility is rigorous.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Radix Cudraniae: lightly seasoned; Micro-hardship; Cool in nature.Dispelling wind and removing obstruction in the collateral; Removing damp-heat; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Traumatic injury; Yellow cellulitis; Parotitis; Pulmonary tuberculosis; Gastric duodenal ulcer; Stranguria with turbid discharge; Distention of the abdomen caused by various parasites; Amenorrhea; Impairment caused by overstrain hemoptysis; Treatment carbuncle sore swells.

Radix Cephalanthi Occidentalis: another name water Yang Mei Jiang, Fructus Myricae rubrae tree root, Radix Gei japonici, Eight Diagrams wind, Huang are excellent.For the root of dicotyledon medicine Maguireothamnus speciosus buttonbush.Bitter; Cool.Return lung; Large intestine channel.Clearing away heat-damp and promoting diuresis; Dissipating blood stasis for subsidence of swelling.Main cold, fever; Cough; Laryngopharynx swelling and pain; Hepatitis; Urinary tract infection; Pelvic inflammatory disease; Orchitis; Rheumatic arthritis; Carbuncle; Traumatic injury.

Herba astilbes chinensis: call little Rhizoma Cimicifugae, art work, horse hair ginseng, mountain flower seven, Ah root eight, ferrum fire tongs, Ba Si-Ao Lu element, golden tail earthworm.For the herb of saxifragaceae plant Herba astilbes chinensis, large Herba astilbes chinensis.Cool; Bitter.Return lung meridian.Dispel the wind; Heat clearing away; Cough-relieving.Main anemopyretic cold; Head-body-pain; Cough.

Fructus Aristolochiae: bitter; Pungent; Cold.Return lung meridian.Lung heat clearing sending down the abnormal ascending QI; Relieving cough and asthma; Let out large intestine clearly.Main cough due to lung-heat; Expectorant stops up tachypnea; Chronic cough of deficiency lung; The hot hemorrhoidal bleeding of intestinal; Swelling and pain of hemorrhoid; Edema.

Radix et Rhizoma Dispori Cantoniensis: bitter in the mouth; Pungent; Cool in nature.Wind-damp dispelling; Relaxing muscles and tendons to promote blood circulation; Heat clearing away expelling phlegm for arresting cough.Main air arthralgia chiefly caused by damp pathogen is demonstrate,proved; Joint lumbago and skelalgia; Traumatic injury; Fracture; Asthenia; Osteopyrexia and fever; Pulmonary tuberculosis is spat blood; Cough due to lung-heat; Burn and scald.

Radix Adenophorae Trachelioidis: other name Ni, Di Ni, sweet Radix Platycodonis, native Radix Platycodonis, RADIX ADENOPHORAE, Mei Can, come into leaves Radix Adenophorae (Radix Glehniae).For the root of Campanulaceae Radix Adenophorae Trachelioidis, slender lobule Radix Adenophorae Trachelioidis.Sweet in the mouth; Cold in nature.Return lung; Spleen channel.Moistening the lung and resolving the phlegm; Heat-clearing and toxic substances removing.Main xeropulmonary cough; Laryngopharynx swelling and pain; Quench one's thirst; Furuncle carbuncle sore; Drug intoxication.

Cortex Lycii: cold in nature, sweet in the mouth; Enter lung, liver, kidney channel." not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat." " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, alternate attacks of chills and fever, allly sees blood disorder, epistaxis, cough blood, and cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine." removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Cure mainly hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition generates heat, and quench one's thirst, pulmonary cough is breathed heavily, and spits blood, epistaxis, hematuria.Modern times are used for the treatment of hypertension, flat wart, palmoplantar verruca, universal eczema, pulpitis pain etc.

Semen Ginkgo: ginkgo nut is commonly called as Semen Ginkgo.Property is put down, and sweet in the mouth is pained, slightly poisonous; Enter lung, kidney channel.Astringe the lung gas, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, in vain tumor wind.The ginkgolic acid contained in Semen Ginkgo, bilobol, the experiment proved that antibacterial and bactericidal action, can be used for treating respiratory tract infectious disease.Semen Ginkgo water logging agent has inhibitory action in various degree to various fungus, can antipruritic treatment tinea.Ginkgolic acid contained in Semen Ginkgo episperm and bilobol etc., have the effect of anti-mycobacterium tuberculosis.

Flos Farfarae: acrid in the mouth, warm in nature; Return lung meridian.Relieving cough and asthma, therapeutic method to keep the adverse QI flowing downwards expectorant." Japan hanako materia medica ": " relieving restlessness, benefit labor is bad, stopping coughing and removing phlegm, and pulmonary fistula is spitted blood, and palpitation with fear of having a guilty conscience, washes liver improving eyesight and apoplexy for profit cardiopulmonary, beneficial the five internal organs." " book on Chinese herbal medicine take advantage of refined half brave ": " Flos Farfarae with controlling cough with dyspnea, kindly breathing heavily, sore throat, because kidney is bitter dry and cold physique drink is cold, begin suitable by being attacked by pathogenic dampness in autumn person.Or burning hot punishment gold, or withering lung lobes with stuffy lung-QI, probably benefit disappears to sparkle and injures." preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.

Rhizoma Belamcandae: nature and flavor are bitter, cold.Enter lung, Liver Channel.There is heat-clearing and toxic substances removing, throat, expectorant saliva, treat pharynx and close, effect of eliminating carbuncle poison.Modern study shows, it has the effect of resisting pathogenic microbes, antiinflammatory.Rhizoma Belamcandae is for experiencing wind heat, or expectorant heat stops up the diseases such as the laryngopharynx swelling and pain caused by containing.Rhizoma Belamcandae is control the conventional medicine of laryngopharynx swelling and pain, can heat clearing away poison, detumescence pain, the fit applications such as normal and Fructus Arctii, Radix Platycodonis, Radix Glycyrrhizae; For accumulation and obstruction of sputum, Rhizoma Belamcandae clearing away lung-heat during the diseases such as cough and asthma and expectorant saliva, with controlling cough phlegm dyspnea, the fit applications such as normal and Herba Ephedrae, Radix Asteris, coltsfoot.

Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms are sent out for epidemic febrile disease, Indigo Naturalis, containing indigo, indirubin, has the antiviral effect of heat-clearing and toxic substances removing, sore, inhibited to cholera bacilli, Bacillus typhi, dysentery bacterium and fractionated viral.

Concretio Silicea Bambusae: sweet, cold; Enter the heart, liver, lung meridian." Japan hanako materia medica ": " control middle wind-phlegm stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." " Kaibao Bencao ": " main infantile convulsion sky hangs, and relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.

Caulis Sargentodoxae: have another name called Caulis Sargentodoxae.Bitter in the mouth, property is put down, and returns liver, large intestine channel, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery." Hunan medicine will ": " stimulate the menstrual flow and enrich blood, bone and muscle strengthening, anthelmintic.Control traumatic injury, rheumatalgia, bruise, stranguria with blood, bones and muscles pain, furuncle, filaricide.”

Fructificatio Fomitopsis Officinalis: another name fungus of larch.Mycophyta Polyporaceae shelf fungus belongs to bitter white hoof, is used as medicine with sporophore.Sweet, bitter, temperature.Warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, expelling wind and removing dampness, promoting blood circulation and detumescence, diuresis, antidotes against snake bite.For cough, asthma, stomachache, hyperchlorhydria, lithangiuria, nephritis, chronic rheumatic arthritis, pharyngolaryngitis, periodontitis, venom.

Semen Lepidii (Semen Descurainiae): another name fourth is gone through, suitable greatly, large room.For the seed of crucifer Semen Lepidii, qin leaf Semen Lepidii and descurainia sophia (l.) webb ex prantl.Pungent, bitter, Great Cold.Return lung, urinary bladder channel.Eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.

Flos Inulae: bitter in the mouth; Pungent; Salty; Tepor.Return lung; Stomach; Large intestine channel.Expectorant row water; Sending down the abnormal ascending QI preventing or arresting vomiting.Main cough with asthma expectorant glues; To tremble eructation; Feeling of stuffiness in chest hypochondriac pain.

Radix Asteris: pungent, bitter, temperature.Return lung meridian.Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.

Folium Eriobotryae: bitter, pungent; Cold.Return lung; The heart; Stomach warp.Clearing away lung-heat to relieve cough, regulating the stomach and sending down the abnormal ascending QI, quenches the thirst.Main lung-heat phlegmatic cough; Deficiency of YIN chronic cough; Hemoptysis; Epistaxis; Gastric heat is vomitted the sound of vomiting.

Folium Perillae: acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae Herb all has very high nutritive value, and it has low sugar, high microsteping, high carotene, high mineral element etc.Containing perillaldehyde, perilla alcohol, menthone, menthol, eugenol, ergomaketon etc. in volatile oil.

Semen Armeniacae Amarum: bitter, tepor.Return liver, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Be good at falling lung qi to relieving asthma, control breathing with cough of excess of the lung.Amygdalate toxicity comes from amygdalin and is hydrolyzed the hydrocyanic acid discharged, and this material can block the respiratory chain of cell, hinders the generation of ATP.Containing amygdaloside in Semen Armeniacae Amarum, amygdaloside can be hydrolyzed by the emulsin of enteric microorganism enzyme or the contained Semen pruni armeniacae of Semen Armeniacae Amarum itself in vivo, produces hydrocyanic acid and the benzaldehyde of trace, has inhibitory action, reach antitussive, antiasthmatic effect to respiratory center.The Semen Armeniacae Amarum bitter in the mouth therapeutic method to keep the adverse QI flowing downwards, and be rich in fatty oil.Fatty oil can improve the lubrication of intestinal contents to mucosa, therefore Semen Armeniacae Amarum has the function of loosening bowel to relieve constipation.

Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel, Tang etc. " Newly Revised Canon of Materia Medica " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, it is top grade to list in Sheng Nong's herbal classic the earliest, and herbal function is the power of strengthening by means of tonics, and medical value is high, and general collocation selenium making nourishing the liver sheet and bifendate, Bicyclol etc., have hepatoprotective function.Fructus Schisandrae Chinensis is divided into 2 genus, i.e. Kadsura and Schizandra.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, 1. for epidemic febrile disease, evil in edema caused by disorder of QI, the edema caused by disorder of QI excess-heat syndrome of high heat, excessive thirst, has the effect of pathogenic fire purging relieving restlessness, has collaborative effect with Gypsum Fibrosum, Folium Bambusae compatibility.2. be used for the treatment of cough due to lung-heat or deficiency of YIN cough caused by dryness, have and let out lung-fire clearly, the effect of nourishing YIN and moistening the lung.Normal and Bulbus Fritillariae Uninbracteatae is same in order to strengthen the merit of clearing away lung-heat and moistening for dryness, as female loose in " collection of prescriptions with notes " two.3., for hyperactivity of fire caused by deficiency of YIN, osteopyrexia and fever, night sweat person, has the effect of nourishing YIN to lower pathogenic fire, and normal and Cortex Phellodendri mutual reinforcement between is for use.4. can let out clearly the fire of lung stomach, again can the moon of nourishing the lung and kidney, therefore the deficiency of YIN should be used for quench one's thirst, disease sees thirsty, drinking water copiously, frequent micturition person, same to Rhizoma Dioscoreae, Fructus Schisandrae Chinensis etc. with the use of heightening the effect of a treatment, as good wine soup.The Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Radix seu Herba Tetrastigmatis Hypoglauci: acrid in the mouth; Warm in nature.Expelling wind and removing dampness; Reunion of bone; Dissipating blood stasis for subsidence of swelling.Main air pain of dampness syndrome; The traumatic injury fracture injury of tendon and muscle; Burn due to hot liquid or fire; Innominate toxic swelling; Skin wet and rotten.

Radix Ampelopsis delavayanae: pungent; Light; Puckery; Flat.GUIXIN; Liver Channel.Clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Hemostasia and promoting granulation; Removing toxic substances and promoting subsidence of swelling.Main stranguria; Nebulousurine; Hernia; The swelling and hanging down of either of the testes; Rheumatic arthralgia; Traumatic injury congestive edema; Wound hemorrhage; Scald; Carbuncle sore.

Fructus Toosendan: bitter, cold; Return liver, small intestinal, urinary bladder channel.Compendium of Material Medica: " chinaberry is real, leads the heat of small intestinal bladder, mutually fiery descending because drawing heart born of the same parents, therefore cardiac and abdominal pain and hernia are key medicine." " property of medicine opinion ": " in owner, large heat, mad, loses the heart hot-tempered vexed, does soup bath." soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.

Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the disease such as erysipelas, dermatitis rhus.

Radix campsis: another name Radix Campsis.For the root that Bignoniaceae plant is reached the clouds or reach the clouds in America.Sweet in the mouth; Pungent; Cold in nature.Return liver; Spleen; Kidney channel.Cooling blood, expelling wind; Promoting blood circulation to remove obstruction in the collateral.Main blood hot air wind producing; Itching over the body; Rubella; Waist foot is unsuccessful; Gout; Rheumatic arthralgia; Traumatic injury.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance.

Herba Euphorbiae Humifusae: acrid in the mouth; Property is put down.Return lung; Liver; Stomach; Large intestine; Urinary bladder channel.Heat-clearing and toxic substances removing; Dampness removing jaundice eliminating; Promoting blood circulation and hemostasis.Main dysentery; Have loose bowels; Jaundice; Hemoptysis; Spit blood; Hematuria; Have blood in stool; Metrorrhagia; Agalactia; Treating swelling and pain by traumatic injury and pathopyretic ulcer.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.There is obvious and lasting diuresis, to various animal as rat, rabbit, Canis familiaris L. have effect.

Fructus Amomi: acrid in the mouth, warm in nature; Return spleen channel, stomach warp, kidney channel.Function removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.Materia Medica of Decoction: " contracting sand, with Symplocoris Paniculatae, Fructus Amomi Rotundus for making, enters lung, with Radix Ginseng, Fructus Alpiniae Oxyphyllae for making, enters spleen, with Cortex Phellodendri, Poria for making, enters kidney, with red, Kaolin for making, enters large and small intestinal." " Japan hanako materia medica ": " control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain." function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.The pungent loose temperature of these product is led to, fragrant, and its removing dampness is amusing, and the effect of circulation of qi promoting warming middle-JIAO is all good, and ancients say it: " adjust stomach key medicine for being amusing." therefore all cards of incoordination between the spleen and stomach such as all dampness or the abdominal distention caused by the stagnation of QI are conventional, especially cold-damp stagnation of QI person is the most suitable.These product kind energy warming middle-JIAO warming the stomach is to reach the merit of preventing or arresting vomiting antidiarrheal, but it focuses on warming the spleen.

Semen Alpiniae Katsumadai: pungent, temperature; Return lung meridian, spleen channel, stomach warp.Compendium of Material Medica: " control communicable subtropical diseases algid malaria, Sunstroke is told down and let out dysentery, dysphagia and regurgitation, feeling of fullness acid regurgitation, and phlegm retention is gathered, married woman's malignant histocytosis leukorrhagia, and except cold dampness, dissipating depression of QI dispelling the stagnated QI, kills ichthyosacrotoxin." " book on Chinese herbal medicine is original ": " tonifying the spleen and stomach, mill is stagnant, and adjust cold scattering gas very fast, it is the most suitable that weakness can not drink trencherman, alcoholic intoxication of holding concurrently." function removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.

Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Fragrance row is loose, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 medicine 1

Embodiments provide one and be used for the treatment of the emophysematous medicine of cattle, be made up of the raw medicinal material of following parts by weight: Radix Cudraniae 13 parts, Radix Cephalanthi Occidentalis 21 parts, Herba astilbes chinensis 15 parts, Fructus Aristolochiae 19 parts, Radix et Rhizoma Dispori Cantoniensis 25 parts, Radix Adenophorae Trachelioidis 13 parts, Cortex Lycii 21 parts, Semen Ginkgo 11 parts, Flos Farfarae 18 parts, Rhizoma Belamcandae 15 parts, Indigo Naturalis 22 parts, Concretio Silicea Bambusae 17 parts, Caulis Sargentodoxae 15 parts, Fructificatio Fomitopsis Officinalis 23 parts, Semen Lepidii (Semen Descurainiae) 16 parts, Flos Inulae 19 parts, Radix Asteris 23 parts, Folium Eriobotryae 25 parts, Folium Perillae 16 parts, Semen Armeniacae Amarum 8 parts, Fructus Schisandrae Chinensis 13 parts, the Rhizoma Anemarrhenae 21 parts, Radix seu Herba Tetrastigmatis Hypoglauci 12 parts, Radix Ampelopsis delavayanae 14 parts, Fructus Toosendan 7 parts, Pheretima 14 parts, Radix campsis 22 parts, Herba Hedyotidis Diffusae 18 parts and Herba Euphorbiae Humifusae 21 parts.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 medicine 2

Embodiments provide one and be used for the treatment of the emophysematous medicine of cattle, be made up of the raw medicinal material of following parts by weight: Radix Cudraniae 13 parts, Radix Cephalanthi Occidentalis 21 parts, Herba astilbes chinensis 15 parts, Fructus Aristolochiae 19 parts, Radix et Rhizoma Dispori Cantoniensis 25 parts, Radix Adenophorae Trachelioidis 13 parts, Cortex Lycii 21 parts, Semen Ginkgo 11 parts, Flos Farfarae 18 parts, Rhizoma Belamcandae 15 parts, Indigo Naturalis 22 parts, Concretio Silicea Bambusae 17 parts, Caulis Sargentodoxae 15 parts, Fructificatio Fomitopsis Officinalis 23 parts, Semen Lepidii (Semen Descurainiae) 16 parts, Flos Inulae 19 parts, Radix Asteris 23 parts, Folium Eriobotryae 25 parts, Folium Perillae 16 parts, Semen Armeniacae Amarum 8 parts, Fructus Schisandrae Chinensis 13 parts, the Rhizoma Anemarrhenae 21 parts, Radix seu Herba Tetrastigmatis Hypoglauci 12 parts, Radix Ampelopsis delavayanae 14 parts, Fructus Toosendan 7 parts, Pheretima 14 parts, Radix campsis 22 parts, Herba Hedyotidis Diffusae 18 parts, Herba Euphorbiae Humifusae 21 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Amomi 14 parts, Semen Alpiniae Katsumadai 19 parts, Radix Et Rhizoma Nardostachyos 13 parts and 23 parts, Radix Glycyrrhizae.

Its preparation method is as follows:

The first step, Radix Cudraniae, Fructus Aristolochiae, Radix et Rhizoma Dispori Cantoniensis, Flos Farfarae, Concretio Silicea Bambusae, Caulis Sargentodoxae, Fructificatio Fomitopsis Officinalis, Semen Lepidii (Semen Descurainiae), Radix campsis and Herba Euphorbiae Humifusae are mixed in described ratio, with being the dissolve with ethanol of 90% relative to the determining alcohol of 4 times of mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Cephalanthi Occidentalis, Radix Adenophorae Trachelioidis, Cortex Lycii, Rhizoma Belamcandae, Flos Inulae, Radix Asteris, Folium Eriobotryae and Folium Perillae are mixed in described ratio, add the ethanol of the determining alcohol 90% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the mastic of 1.22, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 1.5 times relative to the mixture quality obtained, again heat decoction 1.5 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 100 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The toxicity test 1 of medicine:

1, trial drug

Choose Radix Cudraniae 13g, Radix Cephalanthi Occidentalis 21g, Herba astilbes chinensis 15g, Fructus Aristolochiae 19g, Radix et Rhizoma Dispori Cantoniensis 25g, Radix Adenophorae Trachelioidis 13g, Cortex Lycii 21g, Semen Ginkgo 11g, Flos Farfarae 18g, Rhizoma Belamcandae 15g, Indigo Naturalis 22g, Concretio Silicea Bambusae 17g, Caulis Sargentodoxae 15g, Fructificatio Fomitopsis Officinalis 23g, Semen Lepidii (Semen Descurainiae) 16g, Flos Inulae 19g, Radix Asteris 23g, Folium Eriobotryae 25g, Folium Perillae 16g, Semen Armeniacae Amarum 8g, Fructus Schisandrae Chinensis 13g, Rhizoma Anemarrhenae 21g, Radix seu Herba Tetrastigmatis Hypoglauci 12g, Radix Ampelopsis delavayanae 14g, Fructus Toosendan 7g, Pheretima 14g, Radix campsis 22g, Herba Hedyotidis Diffusae 18g and Herba Euphorbiae Humifusae 21g mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

The toxicity test 2 of medicine:

1, trial drug

Choose Radix Cudraniae 13g, Radix Cephalanthi Occidentalis 21g, Herba astilbes chinensis 15g, Fructus Aristolochiae 19g, Radix et Rhizoma Dispori Cantoniensis 25g, Radix Adenophorae Trachelioidis 13g, Cortex Lycii 21g, Semen Ginkgo 11g, Flos Farfarae 18g, Rhizoma Belamcandae 15g, Indigo Naturalis 22g, Concretio Silicea Bambusae 17g, Caulis Sargentodoxae 15g, Fructificatio Fomitopsis Officinalis 23g, Semen Lepidii (Semen Descurainiae) 16g, Flos Inulae 19g, Radix Asteris 23g, Folium Eriobotryae 25g, Folium Perillae 16g, Semen Armeniacae Amarum 8g, Fructus Schisandrae Chinensis 13g, Rhizoma Anemarrhenae 21g, Radix seu Herba Tetrastigmatis Hypoglauci 12g, Radix Ampelopsis delavayanae 14g, Fructus Toosendan 7g, Pheretima 14g, Radix campsis 22g, Herba Hedyotidis Diffusae 18g, Herba Euphorbiae Humifusae 21g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Amomi 14g, Semen Alpiniae Katsumadai 19g, Radix Et Rhizoma Nardostachyos 13g and Radix Glycyrrhizae 23g mixes, be ground into powder, added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue, again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate, merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

Contrast test

Shandong Province's veterinary station, in December ,-2013, saw and treated patients 165 and suffered from cattle in March, 2012, suffered from cattle and occurred that spirit is depressed, poor appetite is to absolutely useless, and rhinorrhea is slurry property, upper abdomen distension, cough with dyspnea and rough breath, and expectorant is yellow, order is swollen, and eyeball is dashed forward, and sheds tears, fever and sweating, yellow urine dry stool, tongue is mulberry, slippery and rapid pulse, body temperature majority is increased to 40.5 DEG C, and in mouth, flow out white foam thing, milk yield die-offs, heartbeat increases to 100-160 time per minute, and cardiac rhythm is uneven, muffled heart sounds.Chest percussion can be tympanitic resonance, and auscultation of lung has friction sound and sound of vomiting sound.Be diagnosed as emphysema.

Choose 90 ill cattle, be divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, three groups in body weight, the state of an illness etc. all without significant difference, there is comparability.Embodiment group 1, embodiment group 2 and matched group use the powder of the injectable powder of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively; Wherein, injectable powder adopts intramuscular injection, each 0.6mg/kg, once a day, and injection 7 days continuously; The using method of powder adds in conventional feed by powder according to the part by weight of 4:100, feeds continuously 7 days; Conventional medicament is intramuscular injection atropine 0.05mg/kg, an intramuscular injection, every day twice; Ground plug rice 10-20mg, a muscle, once a day, is used in conjunction 3d; Use levofloxacin auxiliary treatment, treatment carries out 7, conventional feed of feeding simultaneously.Experimental period is 7 days, and result is as shown in table 1.Wherein, cure: spirit is normal, breathing and appetite are drunk water normal; Invalid: clinical symptoms is not improved and even increased the weight of or death.

The therapeutic effect synopsis of table 1 three experimental group cattle

Data from table 1: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has evident in efficacy, determined curative effect, cheap, the advantage that has no side effect in treatment pulmonis Bovis seu Bubali edema due to disorder of QI.

Model case

20, farm, Binzhou, in JIUYUE, 2013 Shandong cattle occurs that spirit is depressed, and poor appetite, to absolutely useless, is shed tears, rhinorrhea is slurry property, upper abdomen distension, cough with dyspnea and rough breath, and order is swollen, and eyeball is dashed forward, yellow urine dry stool, tongue is mulberry, slippery and rapid pulse, body temperature majority is increased to 40.5 DEG C, and in mouth, flow out white foam thing, milk yield die-offs, heartbeat increases to 100-160 time per minute, and cardiac rhythm is uneven, muffled heart sounds, chest percussion can be tympanitic resonance, and auscultation of lung has friction sound and sound of vomiting sound.Be diagnosed as emphysema.Inject the injectable powder of the embodiment of the present invention 1 immediately, each 0.6mg/kg, once a day, after 4 days, sick cattle breathes and is tending towards normal, normal diet, and symptom is obviously improved, 18 recoveries from illness in the 5th day, 2 recoveries from illness of the 7th day residue.All are followed up a case by regular visits to normal after half a year.

32 cattle that cultivation factory of Shandong in February, 2013 Huantai County raises occur that spirit is depressed, and poor appetite is to absolutely useless, and rhinorrhea is in slurry property, upper abdomen distension, cough with dyspnea and rough breath, order is swollen, and eyeball is dashed forward, and tongue is mulberry, slippery and rapid pulse, body temperature majority is increased to 40.5 DEG C, flows out white foam thing in mouth, milk yield die-offs, heartbeat increases to 100-160 time per minute, and cardiac rhythm is uneven, muffled heart sounds, chest percussion can be tympanitic resonance, and auscultation of lung has friction sound and sound of vomiting sound.Detection is diagnosed as emphysema.Feed immediately and be added with the feedstuff of the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 3:100 weight ratio.After 3 days, most cattle symptom of suffering from starts obvious improvement, recovery from illness in the 4th day 28, remains 4 recoveries from illness in the 6th day.All are followed up a case by regular visits to normal after half a year.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. one kind is used for the treatment of the emophysematous medicine of cattle, it is characterized in that, described medicine comprises following raw medicinal material: Radix Cudraniae, Radix Cephalanthi Occidentalis, Herba astilbes chinensis, Fructus Aristolochiae, Radix et Rhizoma Dispori Cantoniensis, Radix Adenophorae Trachelioidis, Cortex Lycii, Semen Ginkgo, Flos Farfarae, Rhizoma Belamcandae, Indigo Naturalis, Concretio Silicea Bambusae, Caulis Sargentodoxae, Fructificatio Fomitopsis Officinalis, Semen Lepidii (Semen Descurainiae), Flos Inulae, Radix Asteris, Folium Eriobotryae, Folium Perillae, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, the Rhizoma Anemarrhenae, Radix seu Herba Tetrastigmatis Hypoglauci, Radix Ampelopsis delavayanae, Fructus Toosendan, Pheretima, Radix campsis, Herba Hedyotidis Diffusae and Herba Euphorbiae Humifusae.

2. be according to claim 1ly used for the treatment of the emophysematous medicine of cattle, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Cudraniae 10-15 part, Radix Cephalanthi Occidentalis 16-25 part, Herba astilbes chinensis 11-18 part, Fructus Aristolochiae 15-24 part, Radix et Rhizoma Dispori Cantoniensis 23-28 part, Radix Adenophorae Trachelioidis 10-16 part, Cortex Lycii 17-26 part, Semen Ginkgo 8-13 part, Flos Farfarae 14-25 part, Rhizoma Belamcandae 10-16 part, Indigo Naturalis 20-26 part, Concretio Silicea Bambusae 10-18 part, Caulis Sargentodoxae 11-17 part, Fructificatio Fomitopsis Officinalis 20-26 part, Semen Lepidii (Semen Descurainiae) 11-18 part, Flos Inulae 15-25 part, Radix Asteris 16-28 part, Folium Eriobotryae 15-27 part, Folium Perillae 13-18 part, Semen Armeniacae Amarum 6-10 part, Fructus Schisandrae Chinensis 12-18 part, Rhizoma Anemarrhenae 20-26 part, Radix seu Herba Tetrastigmatis Hypoglauci 11-16 part, Radix Ampelopsis delavayanae 10-19 part, Fructus Toosendan 5-9 part, Pheretima 13-18 part, Radix campsis 20-25 part, Herba Hedyotidis Diffusae 15-22 part and Herba Euphorbiae Humifusae 20-26 part.

3. be according to claim 1 and 2ly used for the treatment of the emophysematous medicine of cattle, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Cudraniae 13 parts, Radix Cephalanthi Occidentalis 21 parts, Herba astilbes chinensis 15 parts, Fructus Aristolochiae 19 parts, Radix et Rhizoma Dispori Cantoniensis 25 parts, Radix Adenophorae Trachelioidis 13 parts, Cortex Lycii 21 parts, Semen Ginkgo 11 parts, Flos Farfarae 18 parts, Rhizoma Belamcandae 15 parts, Indigo Naturalis 22 parts, Concretio Silicea Bambusae 17 parts, Caulis Sargentodoxae 15 parts, Fructificatio Fomitopsis Officinalis 23 parts, Semen Lepidii (Semen Descurainiae) 16 parts, Flos Inulae 19 parts, Radix Asteris 23 parts, Folium Eriobotryae 25 parts, Folium Perillae 16 parts, Semen Armeniacae Amarum 8 parts, Fructus Schisandrae Chinensis 13 parts, the Rhizoma Anemarrhenae 21 parts, Radix seu Herba Tetrastigmatis Hypoglauci 12 parts, Radix Ampelopsis delavayanae 14 parts, Fructus Toosendan 7 parts, Pheretima 14 parts, Radix campsis 22 parts, Herba Hedyotidis Diffusae 18 parts and Herba Euphorbiae Humifusae 21 parts.

4. according to any one of claim 1-3, be used for the treatment of the emophysematous medicine of cattle, it is characterized in that, described medicine also comprises the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Semen Alpiniae Katsumadai, Radix Et Rhizoma Nardostachyos and Radix Glycyrrhizae.

5. according to any one of claim 1-4, be used for the treatment of the emophysematous medicine of cattle, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Cudraniae 10-15 part, Radix Cephalanthi Occidentalis 16-25 part, Herba astilbes chinensis 11-18 part, Fructus Aristolochiae 15-24 part, Radix et Rhizoma Dispori Cantoniensis 23-28 part, Radix Adenophorae Trachelioidis 10-16 part, Cortex Lycii 17-26 part, Semen Ginkgo 8-13 part, Flos Farfarae 14-25 part, Rhizoma Belamcandae 10-16 part, Indigo Naturalis 20-26 part, Concretio Silicea Bambusae 10-18 part, Caulis Sargentodoxae 11-17 part, Fructificatio Fomitopsis Officinalis 20-26 part, Semen Lepidii (Semen Descurainiae) 11-18 part, Flos Inulae 15-25 part, Radix Asteris 16-28 part, Folium Eriobotryae 15-27 part, Folium Perillae 13-18 part, Semen Armeniacae Amarum 6-10 part, Fructus Schisandrae Chinensis 12-18 part, Rhizoma Anemarrhenae 20-26 part, Radix seu Herba Tetrastigmatis Hypoglauci 11-16 part, Radix Ampelopsis delavayanae 10-19 part, Fructus Toosendan 5-9 part, Pheretima 13-18 part, Radix campsis 20-25 part, Herba Hedyotidis Diffusae 15-22 part, Herba Euphorbiae Humifusae 20-26 part, Rhizoma Atractylodis Macrocephalae 13-19 part, Fructus Amomi 10-18 part, Semen Alpiniae Katsumadai 15-22 part, Radix Et Rhizoma Nardostachyos 10-16 part and Radix Glycyrrhizae 15-28 part.

6. according to any one of claim 1-5, be used for the treatment of the emophysematous medicine of cattle, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Radix Cudraniae 13 parts, Radix Cephalanthi Occidentalis 21 parts, Herba astilbes chinensis 15 parts, Fructus Aristolochiae 19 parts, Radix et Rhizoma Dispori Cantoniensis 25 parts, Radix Adenophorae Trachelioidis 13 parts, Cortex Lycii 21 parts, Semen Ginkgo 11 parts, Flos Farfarae 18 parts, Rhizoma Belamcandae 15 parts, Indigo Naturalis 22 parts, Concretio Silicea Bambusae 17 parts, Caulis Sargentodoxae 15 parts, Fructificatio Fomitopsis Officinalis 23 parts, Semen Lepidii (Semen Descurainiae) 16 parts, Flos Inulae 19 parts, Radix Asteris 23 parts, Folium Eriobotryae 25 parts, Folium Perillae 16 parts, Semen Armeniacae Amarum 8 parts, Fructus Schisandrae Chinensis 13 parts, the Rhizoma Anemarrhenae 21 parts, Radix seu Herba Tetrastigmatis Hypoglauci 12 parts, Radix Ampelopsis delavayanae 14 parts, Fructus Toosendan 7 parts, Pheretima 14 parts, Radix campsis 22 parts, Herba Hedyotidis Diffusae 18 parts, Herba Euphorbiae Humifusae 21 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Amomi 14 parts, Semen Alpiniae Katsumadai 19 parts, Radix Et Rhizoma Nardostachyos 13 parts and 23 parts, Radix Glycyrrhizae.

7. according to any one of claim 1-6, be used for the treatment of the emophysematous medicine of cattle, it is characterized in that, the dosage form of described medicine is injectable powder, and its preparation method comprises the following steps:

8. according to any one of claim 1-6, be used for the treatment of the emophysematous medicine of cattle, it is characterized in that, the dosage form of described medicine is powder, and its preparation method comprises the following steps:

9. the preparation method being used for the treatment of the emophysematous medicine of cattle as described in any one of claim 1-6, is characterized in that, the dosage form of described medicine is injectable powder, and its preparation method comprises the following steps:

10. the preparation method being used for the treatment of the emophysematous medicine of cattle as described in any one of claim 1-6, is characterized in that, the dosage form of described medicine is powder, and its preparation method comprises the following steps: