CN105303604A - Measuring method and system for single-side osteal damage of human body - Google Patents

Abstract

The invention discloses a method and system for measuring skeletal bone damage of one side of a human body. Using the shape of the corresponding bone on the healthy side as a template, flip the 3D CT image of the corresponding bone on the healthy side into a mirror image, and subtract the 3D CT image of the bone on the affected side to obtain the precise shape of the bone defect on the affected side; measure the maximum length of the bone defect, Parameters such as width, depth, and spatial position of the defect can be used to achieve a comprehensive assessment of the bony defect on the affected side. The invention realizes the model reconstruction and three-dimensional measurement of bone defects in the human unilateral extremity bones, can accurately and comprehensively evaluate the bony defects, and is of great significance for effectively reducing the recurrence rate of postoperative recurrence of diseases caused by bone bony defects .

Description

A method and system for measuring skeletal bone damage of unilateral limbs of human body

technical field

The invention belongs to the field of computer-aided medicine, and in particular relates to a method and a system for measuring skeletal bone damage of one side of a human body.

Background technique

Many orthopedic patients have unilateral limb bony injuries and partial bony structural defects due to various reasons such as trauma, strain, tumor or autoimmune diseases. In such cases, reconstruction of the defective bone structure is often required in order to restore the function of the affected limb. At this time, only by accurately understanding the morphological characteristics of the bony structure at the defect site can the surgical reconstruction method be effectively planned.

Because in this case, the bone structure of the affected side is often partially damaged or missing, it is difficult to infer the precise morphological characteristics of the pre-injury bone based on the existing bone shape of the affected side alone. At present, a large number of anatomical studies on various parts of the human body have confirmed that the bony structures of the corresponding parts of the bilateral limbs are often mirror images of each other, and their shapes are very similar. In this case, the bone structure of the corresponding part of the healthy side can be used as a template of the undamaged shape of the affected side to calculate the missing part of the bone structure of the affected side. Because this template has the individual characteristics of the patient itself, it is more in line with the individual characteristics of the patient than the method of using the general parameters or general shape model of the bone as a reference template for calculation.

Contents of the invention

Aiming at the above problems, the present invention proposes a method and system for measuring skeletal bone damage on one side of the human body. Using the shape of the corresponding bone on the healthy side as a template, the three-dimensional CT image of the corresponding bone on the healthy side is turned into a mirror image, and subtracted Three-dimensional CT images of the bone on the affected side to obtain the precise shape of the bone defect on the affected side; parameters such as the maximum length, width, depth, and spatial position of the bone defect are measured to achieve a comprehensive assessment of the bone defect on the affected side.

The technical scheme that the present invention adopts is as follows:

A method for measuring skeletal bone damage of one side of a human body, comprising the following steps:

1) Segment the medical image containing the same target bone on both sides of the same patient, and extract the bone area of the healthy side and the bone area of the affected side respectively.

2) Three-dimensional reconstruction is performed on the segmented image of the healthy-side bone region and the image of the affected-side bone region to obtain a three-dimensional model of the healthy-side bone and a three-dimensional model of the affected-side bone.

3) According to the position of the key anatomical landmarks and the morphological characteristics of the anatomical structure, analyze and identify the important anatomical structures of the three-dimensional model of the healthy side bone and the three-dimensional model of the affected side bone, and constrain the important anatomical structure that is a mirror image of each other, and the healthy side bone The three-dimensional model of the bone is registered with the three-dimensional model of the bone on the affected side to obtain a registration matrix in which the corresponding bone on the affected side is registered to the corresponding bone on the healthy side.

4) Using the registration matrix obtained in step 3), calculate the difference between the bone area image of the healthy side and the bone area image of the affected side, and obtain the bone defect tomographic image of the affected bone.

5) Three-dimensional reconstruction is performed on the tomographic image of the bone defect to obtain a three-dimensional model of the bone defect.

6) Establishing a three-dimensional coordinate system of the bone where the bone defect is located, and measuring the parameters of the bone defect.

Further, a medical image segmentation algorithm is used to segment the medical image.

Preferably, step 1) uses a threshold-based segmentation algorithm, supplemented by a manual fine-tuning method to segment the medical image, including:

1-1) Image segmentation based on threshold. Select a threshold range to perform threshold segmentation on the same sequence of medical images.

1-2) Manually adjust the segmentation results of a single image. Sequentially browse the images after threshold segmentation. For the obvious unclosed bone edge, manually draw dots or draw lines to close the bone edge; Adhesive part is separated.

Further, in steps 2) and 5), the 3D reconstruction technology in computer graphics is used to perform the 3D modeling, such as MC (MarchingCube, moving cube) algorithm and the like.

Further, step 3) uses a registration algorithm in computer science to perform 3D model registration, such as ICP (Iterative Closest Point, Iterative Closest Point) algorithm and the like.

The above registration process includes: by calculating the error distance between the point cloud of the affected side and the point cloud of the healthy side after rotation and translation, if the error is greater than the preset threshold, continue to iterate the whole process until the error is less than the preset threshold, then the registration is considered Successful; the registration can then be fine-tuned manually, such as shifting or rotating.

Further, step 4) specifically includes the following steps:

4-1) using the registration matrix obtained in step 3) to perform three-dimensional space transformation on all voxels in the segmented ipsilateral bone region, and locate corresponding voxels in the healthy side skeletal region;

4-2) According to the voxel correspondence in the three-dimensional model of the healthy side and the affected side bone, calculate the difference between the healthy side bone image and the affected side bone image, and obtain the bone defect tomographic image of the affected side bone;

4-3) Using the tomographic image of the bone defect obtained in the previous step, reconstruct the three-dimensional model of the bone defect to obtain the original shape of the bone defect.

Further, step 6) establishes the three-dimensional coordinate system of the bone where the defect is located by adopting the establishment method of the three-dimensional coordinate system in the computer system, such as taking the center of gravity of the bone as the coordinate origin, establishing a left-handed coordinate system, that is, the x axis is rightward, the y axis is upward, and the z axis is axis forward.

Further, in step 6), the parameters of the bone defect include: the maximum length, width, depth of the bone defect and the spatial position of the bone defect on the healthy bone. The linear measurement tool is selected to determine the maximum length of the bone defect by clicking with the mouse and The two endpoints of width and depth determine the value of the parameter; select the position measurement tool to determine the deepest position of the bone defect by clicking the mouse, and determine the three-dimensional coordinates of the position; select the angle measurement tool to measure the direction of the defect; select Volume measurement tool to measure the volume of bone defects.

A system for measuring skeletal bone damage of one side of a human body, including: a display module, an interaction module, a bone defect processing module, and a data storage module, wherein:

The bone defect processing module further includes:

The image segmentation sub-module is used to segment the image to be processed, and extract the bone area of the healthy side and the bone area of the affected side respectively;

The three-dimensional reconstruction sub-module is used to perform three-dimensional reconstruction on the segmented healthy-side bone region image, the affected-side bone region image and the tomographic image of the bone defect to obtain the healthy-side bone three-dimensional model, the affected-side bone three-dimensional model and the bone defect three-dimensional model respectively;

The registration sub-module is used to register the three-dimensional model of the healthy bone and the three-dimensional model of the affected bone, and obtain a registration matrix corresponding to the registration of the affected bone to the corresponding bone of the healthy side;

The bone defect tomographic image acquisition submodule is used to acquire the bone defect tomographic image;

The anatomical structure measurement sub-module is used to construct the three-dimensional coordinate system of the bone structure where the defect is located, and provide the tools required for measurement;

The interaction module is used to detect user input, determine the selected measurement tool, and enable the user to interact with the system to participate in the completion of the parameter measurement of the bone defect;

The display module is used to display the image segmentation results, the three-dimensional model of the healthy bone, the three-dimensional model of the affected bone and the three-dimensional model of the bone defect, and the three-dimensional coordinate system of the bone structure where the defect is located.

Described data storage module comprises again:

The image database is used to store medical image data of patients, image segmentation data after image segmentation processing, and tomographic images of bone defects;

The three-dimensional model database is used to store the three-dimensional model of the healthy bone, the three-dimensional model of the affected bone, and the three-dimensional model of the bone defect;

The anatomical structure database is used to store important anatomical structures of human anatomical skeletal bony landmarks, as well as bilateral corresponding anatomical structure landmarks.

Compared with the prior art, the present invention has the following advantages.

1. The present invention provides a method for accurately measuring skeletal bone damage of one side of a human body.

In the present invention, the advantage lies in the design and realization of a method for applying three-dimensional CT technology to the skeletal bone injury of one limb of the human body. The use of 3D CT technology can accurately describe the morphological characteristics of the bone structure of the human skeleton, and realize the 3D description of the shape of the bone defect and the spatial position of the bone defect on the bone structure that cannot be achieved by the previous 2D measurement method, that is, Accurate and comprehensive measurement of bone defects is realized.

2. The method is based on anatomical related research conclusions, which can measure individual bony injuries more individually and accurately.

In the present invention, the measurement method proposed is based on the conclusion that the bony structures of the corresponding parts of the bilateral limbs in anatomical research are often mirror images of each other, and their shapes are very similar. The former shape template is used to calculate the shape of the missing part of the bony structure on the affected side. Because this template has the individual characteristics of the patient itself, it is more in line with the individual characteristics of the patient than the method of using the general parameters or general shape model of the bone as a reference template for calculation.

3. The present invention realizes a system for measuring humeral head bony defect based on three-dimensional CT technology.

The present invention adopts three-dimensional CT technology, utilizes the conclusion in anatomy that the bony structures of the corresponding parts of the bilateral limbs are often mirror images of each other, and the shape is very similar, combined with computer vision technology, realizes the system for measuring the skeletal bone damage of the human body’s unilateral limbs .

4. The software is specially designed for specific clinical problems, which is easy to use and convenient for clinical application.

The system processing flow is relatively simple and easy to operate. Due to real-time processing, the system can provide real-time feedback on the processing results, which improves the user experience effect.

Description of drawings

For purposes of illustration and not limitation, the foregoing and other aspects of the invention will be explained in more detail with reference to the accompanying drawings, in which:

FIG. 1 is a schematic diagram of a stand-alone mode operation scenario of the system of the present invention.

FIG. 2 is a schematic diagram of a remote mode operation scenario of the system of the present invention.

Fig. 3 is a frame diagram of the system for measuring unilateral limb bone defect according to the present invention.

Fig. 4 is a flow chart of the method for measuring unilateral limb bone defect according to the present invention.

Fig. 5 (a) is the original humeral head CT image of the present invention; Fig. 5 (b) is the image obtained after image segmentation; Fig. 5 (c) is the three-dimensional interactive process display image; Fig. 5 (d) is bilateral humerus Head registration effect diagram; Figure 5(e) is a schematic diagram of the affected bone and bone defect; Figure 5(f) is an image of a bone defect.

detailed description

In order to enable those skilled in the art to better understand the present invention, the present invention will be described in further detail below in conjunction with the examples and accompanying drawings, but this does not constitute a limitation to the present invention.

Fig. 1 and Fig. 2 are the stand-alone mode operation scene and the remote mode operation scene of the system of the present invention respectively. The system processes and analyzes bilateral target bone images from the same patient to restore bone defect morphology and parameter measurement. Among them, the medical imaging apparatus is used by a user to obtain medical images by scanning or imaging a patient. Different medical imaging modalities supporting DICOM standard can be used in this system. For example, medical images may be computed tomography (CT) images and MRI images or any image from a suitable image or data acquisition device.

The image data acquired by the medical imaging device is provided to a computer or a workstation for processing through a storage medium or accessing a medical image data server. The computer or workstation provides a user interface that allows the user to view the medical images, manipulate the images and interact with the system to process the images. The user interface includes a display, which may be a display screen, or an image protector, or may be any other suitable display device capable of visually presenting medical images to the user and presenting graphical and textual content to the user. When operating in remote mode, the system has the authority to access the medical image data server. A medical image data server may be part of the system. It can also be provided by external server providers, such as hospital information systems. Although only a stand-alone computer is shown in FIG. 1, the computer may be any general purpose or special purpose computer. It may also be an embedded system, such as in an image acquisition system including a medical imager.

The system may also include a number of peripheral devices so that the user may reproduce or record the results of intermediate processing or other output of the system. For example, an output peripheral may be a paper-based printer that may be used to produce hard copy reports for sharing with other physicians or for archival purposes. Additionally, output peripherals may include storage media and medical image data servers for converting or storing processed results.

Fig. 3 is a frame diagram of a software system for measuring unilateral extremity bone damage of the present invention. Including interface interaction layer, logic processing layer and data resource layer.

The interface interaction layer is the interface for users to interact with the system. The interface design includes the layout of the menu bar and tool bar, the display design of 2D images and 3D models, including the graphical feedback of image segmentation results, the display of the original 3D model and the target 3D model, and the display of the 3D coordinate system of the bone where the defect is located. . Interactive tools include an interactive image manipulation toolbox, such as picking, filling, and erasing, for manual image segmentation, and an interactive registration toolbox, such as move and rotate, for manual fine-tuning of registration. Measurement tools include a measurement toolbox for bone defect morphology, which can be measured in tomographic images and 3D model space, such as length, width, angle, volume and other measurement tools. Process recording realizes the data recording of the processing process, including patient CT image sequences, parameters of interactive tools, intermediate processing results such as image segmentation results, reconstructed 3D models, model registration to obtain registration matrix and anatomical structure measurement unit to obtain all measurement parameters .

In the logical processing layer, the image segmentation unit completes the preprocessing operation on the original CT images of the healthy side and the affected side bones, extracts the interested parts, and performs three-dimensional reconstruction of the processed segmented images after interactive confirmation by the user. The registration unit registers the three-dimensional models of the healthy side and the affected side, and obtains a registration matrix in which the bone structure of the affected side is registered to the corresponding bone of the healthy side. The bone defect reconstruction unit uses the transformation matrix of the previous step to register the preprocessed CT images of the healthy side and the affected side, obtains the tomographic image of the bone defect, and reconstructs the three-dimensional model of the bone defect; the anatomical structure measurement unit and the interactive processing unit, Establish the coordinate system of the bone structure where the defect is located, and interactively complete the measurement of the position, length, width, angle and other parameters of the bone defect according to the measurement tool selected by the user, and provide parameter feedback.

In the data resource layer, the image database contains the patient’s medical tomography image data such as CT images, image segmentation data after image segmentation processing, and CT images of bone defects; the 3D model database is used to store the 3D images of the corresponding parts of the healthy side and the affected side. Model, the three-dimensional model of the bone defect; the important anatomical structure of the human skeleton stored in the anatomical structure database, and the corresponding anatomical structure landmarks on both sides of the human body.

Fig. 4 is a flow chart of steps for measuring unilateral extremity skeletal bone damage by applying the above scheme. It is divided into four stages: preprocessing stage, model registration stage, bone defect acquisition stage, and defect measurement stage. Take the measurement of humeral head bone defect as an example to illustrate.

In the preprocessing stage, the image segmentation function is mainly completed. In the original CT image of the humeral head (as shown in Figure 5(a)), there are often situations where the boundary line between the humeral head and the scapula is not obvious, and the spongy bone in the bone defect image is confused with the surrounding tissue. Through image segmentation, solve the problem of For the above-mentioned problems, an image containing only the humeral head is extracted to prepare for the next step. Wherein, the segmented image effect is shown in FIG. 5( b ), and the part indicated by the arrow is the target humeral head part.

Among them, the image segmentation method adopts a threshold-based segmentation algorithm, supplemented by a manual fine-tuning method.

(1) Image segmentation based on threshold. Select a threshold range to perform threshold segmentation on the same sequence of CT images.

(2) Manually adjust the segmentation results of a single image. Sequentially browse the images after threshold segmentation. For the obvious unclosed bone edge, use manual drawing to close the bone edge; for the case where the humeral head is adhered to the surrounding tissue, use manual drawing straight secant line to separate the adhered part .

In the model registration stage, the three-dimensional models of the humeral head on the healthy side and the affected side of the patient are mainly registered.

(1) Reconstruct the three-dimensional model of the humeral head on the healthy side and the affected side. The three-dimensional models of the humeral head on the healthy side and the affected side were reconstructed using the MarchingCube algorithm using the images of the healthy and affected humeral heads after image segmentation.

(2) Register the three-dimensional models of the healthy side and the affected side humeral head. Using the ICP registration algorithm, according to the algorithm principle, by calculating the error distance between the point cloud of the affected side and the point cloud of the healthy side after rotation and translation, if the error is greater than the preset threshold, continue to iterate the whole process until the error is less than the preset threshold, Then it is considered that the registration is successful; then the registration can be manually fine-tuned, such as shifting or rotating; the transformation matrix obtained after confirmation is provided to the bone defect acquisition stage. The effect after bilateral humeral head registration is shown in Fig. 5(d).

The bone defect acquisition phase is an important phase of the system. At this stage, the image of the humeral head on the affected side is subtracted from the image of the humeral head on the healthy side to obtain the original shape of the bone defect before partial wear. The following will detail the execution steps of the bone defect acquisition phase:

(1) Registration of tomographic images. The purpose of this step is to "mirror align" the images of the patient's bilateral humeral heads. Using the matching matrix obtained in the model registration stage to register the humeral head on the affected side to the humeral head on the healthy side, perform three-dimensional space transformation on all the voxels in the bone area on the affected side after segmentation, and locate the corresponding voxels in the bone area on the healthy side. white.

(2) Calculate the difference between the bone image of the healthy side and the bone image of the affected side according to the voxel corresponding relationship between the healthy side and the affected side bone model, and obtain the tomographic image of the bone defect of the affected side bone.

(3) Reconstruct the three-dimensional model of the bone defect. Using the tomographic image of the bone defect obtained in the previous step, the three-dimensional model of the bone defect is reconstructed to obtain the original shape of the bone defect. Figure 5(f) shows the bone defect morphology after reconstruction.

In the bone defect measurement stage, the three-dimensional coordinate system of the humeral head is mainly established to measure the maximum length, width, depth of the bone defect, the position of the defect in the humeral head, and the angle between the long axis of the defect and the long axis of the humeral shaft.

(1) Establish the three-dimensional coordinate system of the humeral head. Use the following method to establish the three-dimensional coordinate system of the humeral head: use the establishment method of the three-dimensional coordinate system in the computer system to establish the three-dimensional coordinate system of the humeral head. Up, z-axis forward.

(2) Measure bone defect parameters. Use the linear measurement tool to determine the two endpoints of the maximum length (and width, depth) of the bone defect by clicking with the mouse to determine the value of the parameters; use the position measurement tool to determine the deepest position of the defect by clicking the mouse to determine the The three-dimensional coordinates of the position; use the angle measurement tool to measure the angle between the long axis of the defect and the long axis of the humeral shaft; use the volume measurement tool to measure the volume of the bone defect.

So far, the entire process of measuring the three-dimensional shape of the bone defect has been completed.

In summary, the present invention provides a method and system for accurately measuring unilateral extremity bone damage. By adopting the method, the user can accurately obtain the three-dimensional shape of the bone defect, which greatly reduces the workload and processing time of the measurement. Among them, the embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Those skilled in the art can modify or equivalently replace the technical solution of the present invention without departing from the spirit and scope of the present invention. The scope of protection should be based on the claims.

Claims (10)

1., for a method for human body one-sided bones of extremities ilium damage measurement, comprise the following steps:

1) medical image comprising same patient's bilateral same area target bone is split, extract strong side bony areas and Ipsilateral bony areas respectively;

2) respectively three-dimensional reconstruction is carried out to the strong side bone region image after segmentation and Ipsilateral bone region image, obtain strong side seam bone three-dimensional model and Ipsilateral bone three-dimensional model;

3) according to the position of key anatomical landmarks point and the Morphological Features of anatomical structure, analyze and the important anatomy structure identifying strong side seam bone three-dimensional model and Ipsilateral bone three-dimensional model, and with the important anatomy structure of mirror image each other for constraint, registration is carried out to strong side seam bone three-dimensional model and Ipsilateral bone three-dimensional model, obtains the registration matrix that corresponding Ipsilateral bone is registrated to the corresponding bone in strong side;

4) step 3 is utilized) the registration matrix that obtains, calculate the difference of strong side bone region image and Ipsilateral bone region image, obtain the Cranial defect faultage image of Ipsilateral bone;

5) three-dimensional reconstruction is carried out to Cranial defect faultage image, obtain Cranial defect three-dimensional model;

6) set up the three-dimensional system of coordinate of Cranial defect place bone, Cranial defect parameter is measured.

2. as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, adopt Medical image segmentation algorithm to split medical image.

3., as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, step 1) adopt partitioning algorithm based on threshold value, and be aided with the method for finely tuning manually medical image is split, comprising:

1-1) a selected threshold range performs Threshold segmentation to same sequence medical image;

1-2) sequentially browsing the image after Threshold segmentation, for obviously there is the untight situation in bone edge, adopting manually picture point or setting-out mode to close bone edge; For the situation of the head of humerus with the adhesion of surrounding tissue phase, take manually to draw straight secant mode and phase adhesion part is separated.

4., as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, step 2) and 5) in three-dimensional reconstruction in employing computer graphics carry out described three-dimensional modeling.

5., as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, step 3) adopt the registration Algorithm in computer science to carry out three-dimensional model registration.

6. as claimed in claim 5 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, described registration process comprises: by calculating the Ipsilateral point cloud after rotating translation and the error distance between the some cloud of strong side, if error is greater than predetermined threshold value, continue the whole process of iteration, until error is less than predetermined threshold value, then think that registration is successful.

7., as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, step 4) specifically comprise the following steps:

4-1) utilize step 3) the registration matrix that obtains, carries out three dimensions conversion to all voxels in the Ipsilateral bony areas after segmentation, the corresponding voxel in the bony areas of strong side, location;

4-2) according to the voxel corresponding relation in strong side and Ipsilateral bone three-dimensional model, calculate the difference of strong side seam bone image and Ipsilateral skeletal graph picture, obtain the Cranial defect faultage image of Ipsilateral bone;

4-3) utilization above walks the Cranial defect faultage image obtained, and rebuilds Cranial defect three-dimensional model, obtains the original form of Cranial defect.

8., as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, step 6) adopt the method for building up of three-dimensional system of coordinate in computer system to set up the three-dimensional system of coordinate of defect place bone.

9. as claimed in claim 1 for the method for human body one-sided bones of extremities ilium damage measurement, it is characterized in that, step 6) in, described Cranial defect parameter comprises: Cranial defect maximum length, width, the degree of depth and the Cranial defect locus on healthy bone; Select linear measurement instrument, click two end points of mode determination Cranial defect maximum length and width, the degree of depth with mouse, determine the numerical value of parameter; Preferred site survey instrument, with the innermost position of mouse-click mode determination Cranial defect, determines the three-dimensional coordinate of this position; Select angle measurement tool, measure direction residing for defect; Select volume measurement tool, measure the volume of Cranial defect.

10. measure a system for the one-sided bones of extremities ilium damage of human body, comprise: display module, interactive module, Cranial defect processing module, data memory module, wherein:

Described Cranial defect processing module comprises again:

Iamge Segmentation submodule, for pending Image Segmentation Using, extracts strong side bony areas and Ipsilateral bony areas respectively;

Three-dimensional reconstruction submodule, for carrying out three-dimensional reconstruction to the strong side bone region image after segmentation and Ipsilateral bone region image and Cranial defect faultage image, obtains strong side seam bone three-dimensional model, Ipsilateral bone three-dimensional model and Cranial defect three-dimensional model respectively;

Registration submodule, for carrying out registration to strong side seam bone three-dimensional model, Ipsilateral bone three-dimensional model, obtains the registration matrix that corresponding Ipsilateral bone is registrated to the corresponding bone in strong side;

Cranial defect faultage image obtains submodule, for obtaining Cranial defect faultage image;

Anatomical structure measures submodule, for building the three-dimensional system of coordinate of defect place bone structure, provides the instrument needed for measurement;

Described interactive module, for detecting user's input, judges selected survey instrument, makes user and system carry out alternately, having participated in the parameter measurement of Cranial defect;

Described display module, for showing image segmentation result, is good for side seam bone three-dimensional model, Ipsilateral bone three-dimensional model and Cranial defect three-dimensional model, the three-dimensional system of coordinate of defect place bone structure.

Described data memory module comprises again:

Image data base, for the medical image of store patient, Iamge Segmentation data after Iamge Segmentation process, Cranial defect faultage image;

Three-dimensional modeling data storehouse, for storing strong side seam bone three-dimensional model, Ipsilateral bone three-dimensional model, Cranial defect three-dimensional model;

Anatomical structure database, for storing the important anatomy structure of human anatomy bone bone mark, and the anatomical structure mark that bilateral is corresponding.