CN105267925A - Medicine for treating postpartum pelvic blood stagnation and method for preparing medicine - Google Patents
Medicine for treating postpartum pelvic blood stagnation and method for preparing medicine Download PDFInfo
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Abstract
The invention belongs to the field of gynecological and obstetrical medicines, and particularly relates to a medicine for treating postpartum pelvic blood stagnation and a method for preparing the medicine. The medicine for treating the postpartum pelvic blood stagnation comprises angelica sinensis, ligusticum wallichii, peach seeds, herba leonuri, roasted ginger, prepared licorice, root-bark of peony trees, charred schizonepeta, frankincense, hawthorn, cattail pollen, trogopterus dung, rhizoma corydalis, radix ophiopogonis, schisandra chinensis, fried medicated leaven, fructus amomi, cinnamon, astragalus, white peony roots and prepared radix rehmanniae. The medicine and the method have the advantages that effects of removing blood stagnation, specially nourishing new blood, nourishing blood, regulating qi, tonifying patients during promotion and nourishing the blood during removal can be realized by the medicine which is a medicine composition, the medicine is an effective postpartum medicine in good prescription, and excellent treatment effects can be realized for postpartum uterine contraction heat and poor uterine regression besides the pelvic blood stagnation; the medicine is not a medicine for relieving pain, action mechanisms of the medicine include eliminating the blood stagnation, nourishing the new blood and dispersing lump in the nourished blood, the pain due to the pelvic blood stagnation cannot be treated by the medicine, but abdominal pain due to the pelvic blood stagnation can be treated in new blood nourishing procedures.
Description
Technical field
The invention belongs to department of obstetrics and gynecology drug world, be specifically related to a kind of medicine for the treatment of pelvic venous stasis in puerperal, also relate to the preparation method of above-mentioned medicine.
Background technology
Puerperal, pelvic cavity Blood stasis was clinical common disease, its clinical manifestation is, women's clot in puerperal is more than, lochia, or row and not smooth, stomachache is more than, serious even forms one piece, press what for pain, women is mainly with for being the pain that prolonged lochia or retention of lochia cause, be actually because pelvic congestion does not scatter, knot makes agglomerating and pain that is that cause.This disease is mainly in healthy and strong married woman, it is the performance that blood is had a surplus, not insufficiency of blood, if adopt the medicine of removing blood stasis, although can blood stasis be removed, but can exhaust puerpera's vital essence unavoidably, according to the Therapeutic Principle of Chinese medicine " blood stasis does not go, fresh blood do not give birth to ", the clinical practice Eradicates stasis of blood that confirms only to invigorate blood circulation just can reach the raw object of blood stasis, fresh blood.
Therefore, need to suit the remedy to the case for above-mentioned symptom, invent a kind of not loss women vigour and pelvic venous stasis is had to the Chinese medicine of obvious therapeutic effect.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of medicine effectively treating women's pelvic venous stasis in puerperal, the stomachache that pelvic congestion causes do not specialized in by above-mentioned medicine, but in treatment blood stasis process, repercussive blood, tissue regeneration promoting blood, eliminating stagnation block, eliminates stomachache;
Present invention also offers the preparation method of said medicine.
Treat a medicine for pelvic venous stasis in puerperal, this medicine comprises the raw material of following portions by weight:
Radix Angelicae Sinensis 20-30 Rhizoma Chuanxiong 5-15 Semen Persicae 2-9
Herba Leonuri 3-9 black Rhizoma Zingiberis Recens 1-6 Radix Glycyrrhizae Preparata 1-4
Cortex Moutan 2-8 black Herba Schizonepetae 1-5 Olibanum 1-6
Fructus Crataegi 1-5 Pollen Typhae 1-5 Oletum Trogopterori 2-8
Rhizoma Corydalis 1-5 1-6 Radix Ophiopogonis Fructus Schisandrae Chinensis 3-8
Massa Medicata Fermentata (parched to brown) 1-4 Fructus Amomi 2-10 Cortex Cinnamomi 1-6
Radix Astragali 3-12 Radix Paeoniae Alba 2-10 Radix Rehmanniae Preparata 1-9.
Preferably, above-mentioned medicine comprises the raw material of following portions by weight:
Radix Angelicae Sinensis 22-28 Rhizoma Chuanxiong 5-15 Semen Persicae 2-8
Herba Leonuri 3-9 black Rhizoma Zingiberis Recens 1-6 Radix Glycyrrhizae Preparata 1-4
Cortex Moutan 3-7 black Herba Schizonepetae 1-5 Olibanum 1-6
Fructus Crataegi 1-5 Pollen Typhae 1-4 Oletum Trogopterori 2-7
Rhizoma Corydalis 1-5 1-5 Radix Ophiopogonis Fructus Schisandrae Chinensis 3-7
Massa Medicata Fermentata (parched to brown) 1-4 Fructus Amomi 2-9 Cortex Cinnamomi 1-6
Radix Astragali 3-12 Radix Paeoniae Alba 2-9 Radix Rehmanniae Preparata 1-8.
Preferred, above-mentioned medicine comprises the raw material of following portions by weight:
Radix Angelicae Sinensis 25 Rhizoma Chuanxiong 10 Semen Persicae 6
Herba Leonuri 5 black Rhizoma Zingiberis Recens 3 Radix Glycyrrhizae Preparata 2
Cortex Moutan 5 black Herba Schizonepetae 3 Olibanum 3
Fructus Crataegi 2 Pollen Typhae 3 Oletum Trogopterori 5
Rhizoma Corydalis 3 Fructus Schisandrae Chinensis Radix Ophiopogonis 46
Massa Medicata Fermentata (parched to brown) 2 Fructus Amomi 6 Cortex Cinnamomi 3
The Radix Astragali 8 Radix Paeoniae Alba 7 Radix Rehmanniae Preparata 6.
The preparation method of the medicine of above-mentioned treatment pelvic venous stasis in puerperal, comprises following step:
(1) get above-mentioned preferred parts by weight and get each raw material, put into 300-500 part water and soak 20-40min;
(2) boiled for the medicine intense fire in step (1) rear slow fire is stewed 10-20min slowly, then add 20-50 part yellow wine, continue to decoct 8-15min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use;
(3) in the filtering residue of step (2), add 200-400 part water, the boiled rear slow fire of intense fire stewes 10-20min slowly, then adds 20-50 part yellow wine, continues to decoct 8-15min, Guan Huo, pours out medicinal liquid;
(4) get the medicinal liquid obtained in step (1) and (2), combine, add brown sugar 5-10 part, Stigma Croci 0.001-0.003 part, stirs, and must treat the medicine of pelvic venous stasis in puerperal.
Preferably, in above-mentioned step (1), put into 400 parts of water and soak half an hour.
In above-mentioned step (2), boiled for the medicine intense fire in step (1) rear slow fire is stewed 15min slowly, then adds 40 parts of yellow wine, continue to decoct 12min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use.
In above-mentioned step (3), add 300 parts of water in the filtering residue of step (2), the boiled rear slow fire of intense fire stewes 15min slowly, then adds 40 parts of yellow wine, continues to decoct 12min, Guan Huo, pours out medicinal liquid.
Above-mentioned brown sugar is 8 parts.
Above-mentioned Stigma Croci 0.002 part.
Pharmaceutical composition of the present invention, Eradicates is except blood stasis, and special tissue regeneration promoting blood, hemopoietic is regulated the flow of vital energy, and have benefit in row, having life in change, is good recipe panacea in puerperal, and except treatment pelvic venous stasis, for postpartum uterine contraction heat, uterus involution is bad also good therapeutic effect.Above-mentioned medicine is not the medicine bitterly that relieves the pain, and its mechanism of action is Eradicates blood stasis, and tissue regeneration promoting blood disappears block within hemopoietic, does not treat the pain that pelvic congestion causes, but in the process of tissue regeneration promoting blood, has but treated the colic symptoms that pelvic congestion causes.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
The preparation method of the medicine for the treatment of pelvic venous stasis in puerperal, comprises following step:
(1) get each raw material by following parts by weight, put into 400 parts of water and soak half an hour;
Radix Angelicae Sinensis 25 Rhizoma Chuanxiong 10 Semen Persicae 6
Herba Leonuri 5 black Rhizoma Zingiberis Recens 3 Radix Glycyrrhizae Preparata 2
Cortex Moutan 5 black Herba Schizonepetae 3 Olibanum 3
Fructus Crataegi 2 Pollen Typhae 3 Oletum Trogopterori 5
Rhizoma Corydalis 3 Fructus Schisandrae Chinensis Radix Ophiopogonis 46
Massa Medicata Fermentata (parched to brown) 2 Fructus Amomi 6 Cortex Cinnamomi 3
The Radix Astragali 8 Radix Paeoniae Alba 7 Radix Rehmanniae Preparata 6;
(2) boiled for the medicine intense fire in step (1) rear slow fire is stewed 15min slowly, then add 40 parts of yellow wine, continue to decoct 12min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use;
(3) in the filtering residue of step (2), add 300 parts of water, the boiled rear slow fire of intense fire stewes 15min slowly, then adds 40 parts of yellow wine, continues to decoct 12min, Guan Huo, pours out medicinal liquid;
(4) get the medicinal liquid obtained in step (1) and (2), combine, add 8 parts, brown sugar, Stigma Croci 0.002 part, stirs, and must treat the medicine of pelvic venous stasis in puerperal.
For the curative effect of women's blood stasis disease, lysophosphatidic acid (LPA) in general investigation serum, LPA in serum is mainly subject to activated by thrombin by the platelet in coagulation process and discharges human blood, it is the weight molecules product in blood coagulation and thrombosis, LPA content in blood reflects the development of syndrome of blood stasis to a certain extent and lapses to, and much research also shows LPA and coagulation process is closely related.
The present invention studies with rat experiment the impact that LPA is subject to said medicine.
Concrete experimental procedure is as follows:
Select healthy female sd inbred rats 70, male SD rat 30, Mus is about 10 months age, and its average weight is 220 ± 20 grams;
Experimental agents:
The medicine of A embodiment 1;
Step B gets each raw material by following parts by weight in (1), puts into 400 parts of water and soaks half an hour;
Radix Angelicae Sinensis 25 Rhizoma Chuanxiong 10 Semen Persicae 6
Herba Leonuri 5 black Rhizoma Zingiberis Recens 3 Radix Glycyrrhizae Preparata 2
Cortex Moutan 5 black Herba Schizonepetae 3 Olibanum 3
Oletum Trogopterori 5 Radix Paeoniae Alba 7 Radix Rehmanniae Preparata 6
Rhizoma Corydalis 3 Fructus Schisandrae Chinensis Radix Ophiopogonis 46
Massa Medicata Fermentata (parched to brown) 2 Fructus Amomi 6 Cortex Cinnamomi 3
The Radix Astragali 8;
Compared with embodiment 1, eliminate two taste medicines: Fructus Crataegi, Pollen Typhae; All the other are identical;
C is relative to embodiment 1, and dosage reduces to 3/4;
Following adopted mifepristone sheet is manufactured by Zizhu Pharmaceutical Co., Ltd., Beijing;
Misoprostol tablets by LC-MS is manufactured by Zizhu Pharmaceutical Co., Ltd., Beijing;
Method
Leave and take 10 female rats at random as a control group;
All the other rat adaptabilities raise after female Mus and malely to mate with 2:1, carry out vaginal suppository and vaginal smear microscopy morning next day, to find that the same day of vaginal suppository and sperm was for pregnant 1st day, in gestation the 7th day difference gavage mifepristone sheet (8.3mg/kg, 8:00) with misoprostol (0.1mg/kg, by the change of hemorheology index of correlation, 18:00) duplicating model, judges puerperal, whether blood stasis model copied successfully.
The successful rat of Selection Model 60, is divided into 4 groups (i.e. model group, A, B, C tri-groups) at random, often organizes 15, free diet, adopts gavage (10ml/kg), every day twice, continuous 7 days;
Observation index
Last administration is after 1 hour, by whole rat 35g/L chloral hydrate (10ml/kg) intraperitoneal injection of anesthesia, cut abdominal cavity and expose ventral aorta, puncture abdominal aortic blood anticoagulant, get anticoagulation to detect for hemorheology index, stay the centrifugal rear taking-up supernatant blood plasma of appropriate anticoagulation frozen to be measured;
Indexs measure: adopt rotary blood flow graph to survey blood viscosity index, comprise whole blood low shear rate viscosity (5s
-1), shear rate viscosity (30s in whole blood
-1), whole blood height shear rate viscosity (200s
-1), Plasma Viscosity.Adopt enzyme-linked immunosorbent assay (ELISA) reagent box (Yuan Ye bio tech ltd, Shanghai), detect rat blood serum LPA by ELX-800 microplate reader.
Each group of rat LPA comparision contents, the horizontal compared with normal matched group of model group rats LPA obviously increases, and compares with model group, and A group LPA level significantly reduces.
Testing result is as follows:
Each group of rat blood serum LPA comparision contents
Result of study shows, the medicine of the present embodiment can reduce rat whole blood viscosity and Plasma Viscosity in puerperal to a certain extent, points out medicine of the present invention effective for the treatment for the treatment of postnatal blood stasis disease.In serum, LPA is mainly subject to activated by thrombin by the platelet in coagulation process and discharges, and be the important molecule product in blood coagulation and thrombosis, the relation of LPA and Blood stasis have also been obtained the support of many results of study.
Clinical experiment
King so-and-so, 15 days puerperal, stomachache, anus acid is risen tenesmus, is attended by lumbago, has clot in lochia; Ultrasound diagnosis, finds there is blood stasis in pelvic cavity.
Pelvic congestion belongs to angiopathy more complicated in department of obstetrics and gynecology, the same pelvic inflammatory disease of clinical symptoms, the gynaecopathias such as adnexitis, its principal patient is the women having childbearing history or miscarriage, induced labor history, general employing colorful Doppler ultrasound diagnostic apparatus, adopt frequency be 3.5MHz can detect whether have pelvic congestion through abdomen convex array probe.
Detect through above-mentioned B ultrasonic, find that so-and-so vein of king is gathered into similar round or cellular agglomerate, uterus congestion enlargement, myometrium venectasia; Doctor judges, so-and-so ill disease of king is pelvic venous stasis;
Adopt Drug therapy of the present invention, potion is taken at twice, and every day, sooner or later respectively once after three days, stomachache disappeared, and the mental status is clearly better, and muscle power increases; After five days, malaise symptoms disappears; Ultrasound diagnosis again, finds that pelvic cavity has recovered normal, without blood stasis symptom.
Embodiment 2
The preparation method of the medicine for the treatment of pelvic venous stasis in puerperal, comprises following step:
(1) get each raw material by following parts by weight, put into 300 parts of water and soak 20min;
Radix Angelicae Sinensis 20 Rhizoma Chuanxiong 5 Semen Persicae 2
Herba Leonuri 3 black Rhizoma Zingiberis Recens 1 Radix Glycyrrhizae Preparata 1
Cortex Moutan 2 black Herba Schizonepetae 1 Olibanum 1
Fructus Crataegi 1 Pollen Typhae 1 Oletum Trogopterori 2
Rhizoma Corydalis 1 Fructus Schisandrae Chinensis Radix Ophiopogonis 13
Massa Medicata Fermentata (parched to brown) 1 Fructus Amomi 2 Cortex Cinnamomi 1
The Radix Astragali 3 Radix Paeoniae Alba 2 Radix Rehmanniae Preparata 1;
(2) boiled for the medicine intense fire in step (1) rear slow fire is stewed 10min slowly, then add 20 parts of yellow wine, continue to decoct 8min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use;
(3) in the filtering residue of step (2), add 200 parts of water, the boiled rear slow fire of intense fire stewes 10min slowly, then adds 20 parts of yellow wine, continues to decoct 8min, Guan Huo, pours out medicinal liquid;
(4) get the medicinal liquid obtained in step (1) and (2), combine, add 5 parts, brown sugar, Stigma Croci 0.001 part, stirs, and must treat the medicine of pelvic venous stasis in puerperal.
Embodiment 3
The preparation method of the medicine for the treatment of pelvic venous stasis in puerperal, comprises following step:
(1) get each raw material by following parts by weight, put into 500 parts of water and soak 40min;
Radix Angelicae Sinensis 30 Rhizoma Chuanxiong 15 Semen Persicae 9
Herba Leonuri 9 black Rhizoma Zingiberis Recens 6 Radix Glycyrrhizae Preparata 4
Cortex Moutan 8 black Herba Schizonepetae 5 Olibanum 6
Fructus Crataegi 5 Pollen Typhae 5 Oletum Trogopterori 8
Rhizoma Corydalis 5 Fructus Schisandrae Chinensis Radix Ophiopogonis 68
Massa Medicata Fermentata (parched to brown) 4 Fructus Amomi 10 Cortex Cinnamomi 6
The Radix Astragali 12 Radix Paeoniae Alba 10 Radix Rehmanniae Preparata 9;
(2) boiled for the medicine intense fire in step (1) rear slow fire is stewed 20min slowly, then add 50 parts of yellow wine, continue to decoct 15min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use;
(3) in the filtering residue of step (2), add 400 parts of water, the boiled rear slow fire of intense fire stewes 20min slowly, then adds 50 parts of yellow wine, continues to decoct 15min, Guan Huo, pours out medicinal liquid;
(4) get the medicinal liquid obtained in step (1) and (2), combine, add 10 parts, brown sugar, Stigma Croci 0.003 part, stirs, and must treat the medicine of pelvic venous stasis in puerperal.
Claims (9)
1. treat a medicine for pelvic venous stasis in puerperal, it is characterized in that, described medicine comprises the raw material of following portions by weight:
Radix Angelicae Sinensis 20-30 Rhizoma Chuanxiong 5-15 Semen Persicae 2-9
Herba Leonuri 3-9 black Rhizoma Zingiberis Recens 1-6 Radix Glycyrrhizae Preparata 1-4
Cortex Moutan 2-8 black Herba Schizonepetae 1-5 Olibanum 1-6
Fructus Crataegi 1-5 Pollen Typhae 1-5 Oletum Trogopterori 2-8
Rhizoma Corydalis 1-5 1-6 Radix Ophiopogonis Fructus Schisandrae Chinensis 3-8
Massa Medicata Fermentata (parched to brown) 1-4 Fructus Amomi 2-10 Cortex Cinnamomi 1-6
Radix Astragali 3-12 Radix Paeoniae Alba 2-10 Radix Rehmanniae Preparata 1-9.
2. a kind of medicine for the treatment of pelvic venous stasis in puerperal as claimed in claim 1, it is characterized in that, described medicine comprises the raw material of following portions by weight:
Radix Angelicae Sinensis 22-28 Rhizoma Chuanxiong 5-15 Semen Persicae 2-8
Herba Leonuri 3-9 black Rhizoma Zingiberis Recens 1-6 Radix Glycyrrhizae Preparata 1-4
Cortex Moutan 3-7 black Herba Schizonepetae 1-5 Olibanum 1-6
Fructus Crataegi 1-5 Pollen Typhae 1-4 Oletum Trogopterori 2-7
Rhizoma Corydalis 1-5 1-5 Radix Ophiopogonis Fructus Schisandrae Chinensis 3-7
Massa Medicata Fermentata (parched to brown) 1-4 Fructus Amomi 2-9 Cortex Cinnamomi 1-6
Radix Astragali 3-12 Radix Paeoniae Alba 2-9 Radix Rehmanniae Preparata 1-8.
3. a kind of medicine for the treatment of pelvic venous stasis in puerperal as claimed in claim 1, it is characterized in that, described medicine comprises the raw material of following portions by weight:
Radix Angelicae Sinensis 25 Rhizoma Chuanxiong 10 Semen Persicae 6
Herba Leonuri 5 black Rhizoma Zingiberis Recens 3 Radix Glycyrrhizae Preparata 2
Cortex Moutan 5 black Herba Schizonepetae 3 Olibanum 3
Fructus Crataegi 2 Pollen Typhae 3 Oletum Trogopterori 5
Rhizoma Corydalis 3 Fructus Schisandrae Chinensis Radix Ophiopogonis 46
Massa Medicata Fermentata (parched to brown) 2 Fructus Amomi 6 Cortex Cinnamomi 3
The Radix Astragali 8 Radix Paeoniae Alba 7 Radix Rehmanniae Preparata 6.
4. a kind of preparation method for the treatment of the medicine of pelvic venous stasis in puerperal as claimed in claim 1, comprises following step:
(1) get each raw material by parts by weight described in claim 1, put into 300-500 part water and soak 20-40min;
(2) boiled for the medicine intense fire in step (1) rear slow fire is stewed 10-20min slowly, then add 20-50 part yellow wine, continue to decoct 8-15min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use;
(3) in the filtering residue of step (2), add 200-400 part water, the boiled rear slow fire of intense fire stewes 10-20min slowly, then adds 20-50 part yellow wine, continues to decoct 8-15min, Guan Huo, pours out medicinal liquid;
(4) get the medicinal liquid obtained in step (1) and (2), combine, add brown sugar 5-10 part, Stigma Croci 0.001-0.003 part, stirs, and must treat the medicine of pelvic venous stasis in puerperal.
5. a kind of preparation method for the treatment of the medicine of pelvic venous stasis in puerperal as claimed in claim 4, is characterized in that, in described step (1), put into 400 parts of water and soak half an hour.
6. a kind of preparation method for the treatment of the medicine of pelvic venous stasis in puerperal as claimed in claim 4, it is characterized in that, in described step (2), boiled for medicine intense fire in step (1) rear slow fire is stewed 15min slowly, add 40 parts of yellow wine again, continue to decoct 12min, Guan Huo, pour out medicinal liquid in container, stay filtering residue for subsequent use.
7. a kind of preparation method for the treatment of the medicine of pelvic venous stasis in puerperal as claimed in claim 4, it is characterized in that, in described step (3), 300 parts of water are added in the filtering residue of step (2), the boiled rear slow fire of intense fire stewes 15min slowly, then adds 40 parts of yellow wine, continues to decoct 12min, Guan Huo, pours out medicinal liquid.
8. a kind of preparation method for the treatment of the medicine of pelvic venous stasis in puerperal as claimed in claim 4, it is characterized in that, described brown sugar is 8 parts.
9. a kind of preparation method for the treatment of the medicine of pelvic venous stasis in puerperal as claimed in claim 4, is characterized in that, described Stigma Croci 0.002 part.
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| CN115317587A (en) * | 2022-08-30 | 2022-11-11 | 中山市中智药业集团有限公司 | Composition for regulating puerperium as well as preparation method and application thereof |
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| CN115317587A (en) * | 2022-08-30 | 2022-11-11 | 中山市中智药业集团有限公司 | Composition for regulating puerperium as well as preparation method and application thereof |
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Application publication date: 20160127 |
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