CN105250799A

CN105250799A - Medicine for treating high blood pressure

Info

Publication number: CN105250799A
Application number: CN201510848098.0A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-27
Filing date: 2015-11-27
Publication date: 2016-01-20

Abstract

The invention discloses medicine for treating high blood pressure. According to the medicine, motherwort, hawthorn fruits, laminaria, dutchmanspipe roots, liquorice, gentian, pseudo-ginseng, radix ophiopogonis, rhizoma corydalis decumbentis, radix polygonum multiflorum preparata, semen cassia, ginger pinellia, caulis bambusae in taeniam, bile arisaema, rhizoma acori graminei, polygala tenuifolia, platycladi seeds, uncaria rhynchophylla, selfheal, chrysanthemum, folium mori, radix paeoniae alba, akebiaquinata, saffron crocus, perilla seeds, eucommia ulmoides, achyranthes bidentata, pericarpium citri reticulatae, longhairy antenoron herbs, pomegranate bark, folium ginkgo, artocarpuslingnanensis, salvia miltiorrhiza, apocynum venetum, cacumen biotae, common bluebeard herbs, pollen typhae, corydalis tuber, madder, rhizoma anemarrhenae and caulis spatholobi are subjected to scientific and reasonable compatibility, and the medicine has the effects of calming the liver and suppressing yang and clearing liver-fire, can treat the high blood pressure, is particularly remarkable in the curative effect on lowering the blood pressure and improving blood microcirculation, can improve the immunity of a human body, is safe and free of toxic and side effect and achieves the purposes of treating both symptoms and root causes of the high blood pressure.

Description

A kind of for hypertensive medicine

Technical field

The present invention relates to the field of Chinese medicines, particularly relate to a kind of for hypertensive medicine.

Background technology

Hypertension is the common a kind of chronic cardiovascular disease of modern society, once morbidity, long-term slight illness will be caused to torment to patient, make to suffer impact in various degree the orthobiosis of patient, even threaten the life of people.The early stage non-evident sympton of hypertension incidence, is easily ignored by people, and the continuity patient along with the course of disease there will be headache, dizzy, uncomfortable in chest, cardio palmus shape more, time serious, obnubilation, tic can occur.In view of bringing out, hypertensive factor is various, and modern medicine study still can not explain its cause of disease completely.Hypertension treated by the Western medicine depressor that adopts more now, although rapid-action, very easily produces dependency.The organs such as the heart, brain, kidney are wrecked in these depressor surface blood pressure lowerings actually, also can bring dizziness, feel sick, nervous, asthma, and the multiple side effect such as edema can cause great pain to patient.

Summary of the invention

In view of above-mentioned the deficiencies in the prior art, the object of the present invention is to provide a kind of for hypertensive medicine.

For solving the problems of the technologies described above, technical solution of the present invention comprises:

A kind of for hypertensive medicine, it comprises following component according to weight portion:

Herba Leonuri 5 parts-15 parts, Fructus Crataegi 10 parts-30 parts, Thallus Laminariae (Thallus Eckloniae) 5 parts-20 parts, Radix Aristolochiae 5 parts-15 parts, 5 parts-20 parts, Radix Glycyrrhizae, Radix Gentianae 3 parts-16 parts, Radix Notoginseng 1 part-8 parts, Radix Ophiopogonis 1 part-15 parts, Rhizoma Corydalis Decumbentis 2 parts-11 parts, Radix Polygoni Multiflori Preparata 5 parts-15 parts, Semen Cassiae 15 parts-40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 parts-15 parts, Caulis Bambusae In Taenia 2 parts-11 parts, Arisaema Cum Bile 5 parts-15 parts, Rhizoma Acori Graminei 15 parts-40 parts, Radix Polygalae 5 parts-15 parts, Semen Platycladi 15 parts-30 parts, Ramulus Uncariae Cum Uncis 10 parts-25 parts, Spica Prunellae 10 parts-25 parts, Flos Chrysanthemi 10 parts-25 parts, 10 parts-25 parts, Folium Mori, the Radix Paeoniae Alba 5 parts-20 parts, Caulis Akebiae 15 parts-40 parts, Stigma Croci 5 parts-20 parts, Fructus Perillae 5 parts-20 parts, the Cortex Eucommiae 15 parts-25 parts, Radix Achyranthis Bidentatae 10 parts-30 parts, Pericarpium Citri Reticulatae 10 parts-25 parts, Herba Lysimachiae 10 parts-25 parts, Pericarpium Granati 10 parts-25 parts, Folium Ginkgo 1 part-10 parts, 3 parts-16 parts, osmanthus wood, Radix Salviae Miltiorrhizae 3 parts-16 parts, Herba Apocyni veneti 1 part-8 parts, Cacumen Platycladi 10 parts-25 parts, Herba Caryopteridis Incanae 3 parts-16 parts, Pollen Typhae 3 parts-16 parts, Rhizoma Corydalis 5 parts-15 parts, 10 parts-25 parts, Radix Rubiae, the Rhizoma Anemarrhenae 5 parts-15 parts and Caulis Spatholobi 3 parts-16 parts.

Described medicine, wherein, it comprises following component:

Herba Leonuri 10 parts, Fructus Crataegi 20 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Radix Aristolochiae 10 parts, 16 parts, Radix Glycyrrhizae, Radix Gentianae 12 parts, Radix Notoginseng 5 parts, Radix Ophiopogonis 11 parts, Rhizoma Corydalis Decumbentis 12 parts, Radix Polygoni Multiflori Preparata 10 parts, Semen Cassiae 31 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 11 parts, Caulis Bambusae In Taenia 7 parts, Arisaema Cum Bile 10 parts, Rhizoma Acori Graminei 33 parts, Radix Polygalae 10 parts, Semen Platycladi 20 parts, Ramulus Uncariae Cum Uncis 15 parts, Spica Prunellae 17 parts, Flos Chrysanthemi 20 parts, 15 parts, Folium Mori, the Radix Paeoniae Alba 15 parts, Caulis Akebiae 31 parts, Stigma Croci 15 parts, Fructus Perillae 14 parts, the Cortex Eucommiae 20 parts, Radix Achyranthis Bidentatae 21 parts, Pericarpium Citri Reticulatae 22 parts, Herba Lysimachiae 18 parts, Pericarpium Granati 20 parts, Folium Ginkgo 6 parts, 12 parts, osmanthus wood, Radix Salviae Miltiorrhizae 13 parts, Herba Apocyni veneti 5 parts, Cacumen Platycladi 20 parts, Herba Caryopteridis Incanae 10 parts, Pollen Typhae 11 parts, Rhizoma Corydalis 10 parts, 21 parts, Radix Rubiae, the Rhizoma Anemarrhenae 8 parts and Caulis Spatholobi 12 parts.

One provided by the invention is used for hypertensive medicine, by Herba Leonuri, Fructus Crataegi, Thallus Laminariae (Thallus Eckloniae), Radix Aristolochiae, Radix Glycyrrhizae, Radix Gentianae, Radix Notoginseng, Radix Ophiopogonis, Rhizoma Corydalis Decumbentis, Radix Polygoni Multiflori Preparata, Semen Cassiae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Bambusae In Taenia, Arisaema Cum Bile, Rhizoma Acori Graminei, Radix Polygalae, Semen Platycladi, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Caulis Akebiae, Stigma Croci, Fructus Perillae, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Pericarpium Citri Reticulatae, Herba Lysimachiae, Pericarpium Granati, Folium Ginkgo, Gui Mu, Radix Salviae Miltiorrhizae, Herba Apocyni veneti, Cacumen Platycladi, Herba Caryopteridis Incanae, Pollen Typhae, Rhizoma Corydalis, Radix Rubiae, the Rhizoma Anemarrhenae and Caulis Spatholobi carry out scientific and reasonable compatibility, there is suppressing the hyperactive liver and subsiding YANG, the merit of purging liver-fire, treatment hypertension is particularly in blood pressure lowering, improve blood microcirculation and have obvious curative effects, improve body's immunity, safe without toxic side effect, reach the object for the treatment of both the principal and secondary aspects of a disease.Its basic pharmacology is as follows:

Herba Leonuri, bitter, pungent, be slightly cold, promoting blood flow to regulate menstruation, blood stasis dispelling, inducing diuresis to remove edema;

Fructus Crataegi, acid is sweet, and tepor, helps digestion long-pending, dissipating blood stasis blood, expelling tenia;

Thallus Laminariae (Thallus Eckloniae), gas raw meat, salty in the mouth, has hard masses softening and resolving, expectorant, the function of diuretic;

Radix Aristolochiae, pungent, bitter, cold, suppressing the hyperactive liver pain relieving, removing toxic substances and promoting subsidence of swelling;

Radix Glycyrrhizae, feeble QI, taste is sweet, cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough;

Radix Gentianae, bitter in the mouth, cold in nature, heat clearing and damp drying; Eliminating pathogen in the liver is calmed the frightened;

Radix Notoginseng, sweet, micro-hardship, temperature, dissipating blood stasis stops blooding, subduing swelling and relieving pain,

Radix Ophiopogonis, sweet, micro-hardship, is slightly cold, lung moistening clears away heart-fire, purges heat and promote the production of body fluid, the preventing or arresting vomiting that reduces phlegm, control row water of coughing;

Rhizoma Corydalis Decumbentis, bitter in the mouth, micro-pungent, warm in nature, invigorate blood circulation active, promoting the circulation of QI to relieve pain, expelling wind and removing dampness has effect;

Radix Polygoni Multiflori Preparata is bitter in the mouth, sweet, puckery, warm in nature flat; Invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening, changes turbid blood fat reducing;

Semen Cassiae, bitter in the mouth, sweet, salty, cold nature; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia;

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), pungent, warm; Poisonous, stopping nausea and vomiting by lowering the adverse flow of QI;

Caulis Bambusae In Taenia, sweet in the mouth, cold nature, removing heat-phlegm, relieving restlessness, preventing or arresting vomiting;

Arisaema Cum Bile, bitter in the mouth, cool in nature; Clearing away fire and eliminating phlegm, relieving convulsion fixed chronic;

Rhizoma Acori Graminei, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae,

Radix Polygalae, bitter, pungent, warm, nourish heart blood, relieving convulsion, mind calming, loose sputum;

Semen Platycladi, sweet in the mouth, property is put down, tranquilizing by nourishing the heart, loosening bowel to relieve constipation, hidroschesis;

Ramulus Uncariae Cum Uncis, dispelling pathogenic wind and eliminating phlegm, Dings Jing Epilepsy, peace infantile convulsive seizure due to fright;

Spica Prunellae is pungent, bitter, cold; Clearing away heat-fire, improving eyesight, mass dissipating and swelling eliminating;

Flos Chrysanthemi, cures mainly headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling;

Folium Mori, control pathogenic wind-warm heating, headache, conjunctival congestion, thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis;

The Radix Paeoniae Alba, suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating;

Caulis Akebiae, bitter in the mouth, cold in nature; Have inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness;

Stigma Croci, sweet in the mouth, property is put down, blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization;

Fructus Perillae, in homophony, beneficial the five internal organs, the therapeutic method to keep the adverse QI flowing downwards;

The Cortex Eucommiae, acrid in the mouth, flat, invigorating the liver and kidney, controls spinal column ache, foot and knee flaccidity;

Radix Achyranthis Bidentatae, picric acid is flat, nontoxic; Promoting blood circulation to remove blood stasis, damp eliminating diuresis, heat-clearing and toxic substances removing;

Pericarpium Citri Reticulatae, bitter in the mouth, pungent, warm in nature, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm;

Herba Lysimachiae, sweet in the mouth, micro-hardship, cool in nature, relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, eliminating damp-heat;

Pericarpium Granati, sour in the mouth, puckery, warm in nature, relieving diarrhea with astringents, hemostasis;

Folium Ginkgo, sweet, bitter, puckery, flat, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes turbid blood fat reducing;

Gui Mu, sweet, sour, flat, clearing away lung-heat to relieve cough, promoting blood circulation and hemostasis,

Radix Salviae Miltiorrhizae, bitter in the mouth, is slightly cold, blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle;

Herba Apocyni veneti, lightly seasoned puckery, cool in nature, slightly poisonous, suppressing liver-YANG, clearing away heat and promoting diuresis;

Cacumen Platycladi, bitter, puckery, cold, cooling blood for hemostasis, preventing phlegm from forming and stopping coughing;

Herba Caryopteridis Incanae, acrid in the mouth, warm in nature, dispelling wind to relieve the exterior syndrome, dispelling cold and dehumidification, eliminating stasis to stop pain;

Pollen Typhae, sweet, flat, hemostasis, blood stasis dispelling, treating stranguria;

Rhizoma Corydalis, pungent; Bitter; Temperature; Nontoxic, invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving;

Radix Rubiae, removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulates the menstrual flow;

The Rhizoma Anemarrhenae, bitter in the mouth, cold, nourishing YIN to lower pathogenic fire, moisturizes laxation;

Caulis Spatholobi, bitter but slightly sweet taste, warm in nature; Red complexion enters blood, and matter profit row is loose; There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation.

Clinical data:

For showing the therapeutic effect of medicine of the present invention, the present invention carries out the clinical research of system through 120 routine hypertension, and 120 routine cases all derive from development zone in Qingdao hospital.

Treatment group: choose 60 examples by random method, take Drug therapy of the present invention 21 days.

Matched group: choose 60 examples by random method, take indapamide tablets and treat 21 days.

Two groups in the state of an illness, sex, age, the course of disease etc. through statistical procedures no significant difference.

Instructions of taking: treatment group: the decoction 200 milliliters sooner or later respectively once taking medicine of the present invention every day, treats 21 days.Matched group: give indapamide tablets, one time 1, every day 3 times, buccal after the meal, treats 21 days.

Observation index and method

With reference to the standard of " new Chinese medicine guideline of clinical investigations ".

Treatment group, cures 35 examples, effective 25 examples, invalid 0 example, total effective rate 100%.Matched group, cures 30 examples, effective 20 examples, invalid 10 examples, total effective rate 80%.Between two groups, difference has very significant, and treatment group is obviously better than matched group.

Detailed description of the invention

The invention provides a kind of for hypertensive medicine, for making object of the present invention, technical scheme and effect clearly, clearly, the present invention is described in more detail below.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.

Embodiment 1

Herba Leonuri 15 parts, Fructus Crataegi 30 parts, Thallus Laminariae (Thallus Eckloniae) 20 parts, Radix Aristolochiae 15 parts, 20 parts, Radix Glycyrrhizae, Radix Gentianae 16 parts, Radix Notoginseng 8 parts, Radix Ophiopogonis 15 parts, Rhizoma Corydalis Decumbentis 11 parts, Radix Polygoni Multiflori Preparata 15 parts, Semen Cassiae 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15 parts, Caulis Bambusae In Taenia 11 parts, Arisaema Cum Bile 15 parts, Rhizoma Acori Graminei 40 parts, Radix Polygalae 15 parts, Semen Platycladi 30 parts, Ramulus Uncariae Cum Uncis 25 parts, Spica Prunellae 25 parts, Flos Chrysanthemi 25 parts, 25 parts, Folium Mori, the Radix Paeoniae Alba 20 parts, Caulis Akebiae 40 parts, Stigma Croci 20 parts, Fructus Perillae 20 parts, the Cortex Eucommiae 25 parts, Radix Achyranthis Bidentatae 30 parts, Pericarpium Citri Reticulatae 25 parts, Herba Lysimachiae 25 parts, Pericarpium Granati 25 parts, Folium Ginkgo 10 parts, 16 parts, osmanthus wood, Radix Salviae Miltiorrhizae 16 parts, Herba Apocyni veneti 8 parts, Cacumen Platycladi 25 parts, Herba Caryopteridis Incanae 16 parts, Pollen Typhae 16 parts, Rhizoma Corydalis 15 parts, 25 parts, Radix Rubiae, the Rhizoma Anemarrhenae 15 parts and Caulis Spatholobi 16 parts.

The preparation method for the treatment of hypertensive medicine is as follows:

(1) according to above-mentioned weight by Herba Leonuri, Fructus Crataegi, Thallus Laminariae (Thallus Eckloniae), Radix Aristolochiae, Radix Glycyrrhizae, Radix Gentianae, Radix Notoginseng, Radix Ophiopogonis, Rhizoma Corydalis Decumbentis, Radix Polygoni Multiflori Preparata, Semen Cassiae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Bambusae In Taenia, Arisaema Cum Bile, Rhizoma Acori Graminei, Radix Polygalae, Semen Platycladi, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Caulis Akebiae, Stigma Croci, Fructus Perillae, Cortex Eucommiae(processed with salt), Radix Achyranthis Bidentatae, Pericarpium Citri Reticulatae, Herba Lysimachiae, Pericarpium Granati, Folium Ginkgo, Gui Muye, Radix Salviae Miltiorrhizae, Herba Apocyni veneti, Cacumen Platycladi, Herba Caryopteridis Incanae, Pollen Typhae, Rhizoma Corydalis, Radix Rubiae, the Rhizoma Anemarrhenae and Caulis Spatholobi, mix homogeneously obtains mixture, this mixture is mixed with the ratio of water according to weight ratio 1:3, soak 60 minutes in water.

(2) mixture in described step (1) and soak by water, after 60 minutes, are filtered and obtain the first filtrate and filtering residue.

(3) gained filtering residue in described step (2) is mixed with the ratio of water according to weight ratio 1:2, then decoct 30 minutes, then filter and obtain the second filtrate and filtering residue, the first filtrate is mixed with the second filtrate, obtain the decoction of medicine.

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 29g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by decoction prepared by embodiments of the invention 1, (concentration is 8.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>42.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.6 crude drugs/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 24g) oral administration gavage Chinese medicine of the present invention is 651 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 decoction of the present invention presses 12.32,20.68 and 35.42g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Embodiment 2

Embodiment 3

Herba Leonuri 5 parts, Fructus Crataegi 10 parts, Thallus Laminariae (Thallus Eckloniae) 5 parts, Radix Aristolochiae 5 parts, 5 parts, Radix Glycyrrhizae, Radix Gentianae 3 parts, Radix Notoginseng 1 part, Radix Ophiopogonis 1 part, Rhizoma Corydalis Decumbentis 2 parts, Radix Polygoni Multiflori Preparata 5 parts, Semen Cassiae 15 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 parts, Caulis Bambusae In Taenia 2 parts, Arisaema Cum Bile 5 parts, Rhizoma Acori Graminei 15 parts, Radix Polygalae 5 parts, Semen Platycladi 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Spica Prunellae 10 parts, Flos Chrysanthemi 10 parts, 10 parts, Folium Mori, the Radix Paeoniae Alba 5 parts, Caulis Akebiae 15 parts, Stigma Croci 5 parts, Fructus Perillae 5 parts, the Cortex Eucommiae 15 parts, Radix Achyranthis Bidentatae 10 parts, Pericarpium Citri Reticulatae 10 parts, Herba Lysimachiae 10 parts, Pericarpium Granati 10 parts, Folium Ginkgo 1 part, 3 parts, osmanthus wood, Radix Salviae Miltiorrhizae 3 parts, Herba Apocyni veneti 1 part, Cacumen Platycladi 10 parts, Herba Caryopteridis Incanae 3 parts, Pollen Typhae 3 parts, Rhizoma Corydalis 5 parts, 10 parts, Radix Rubiae, the Rhizoma Anemarrhenae 5 parts and Caulis Spatholobi 3 parts.

Certainly; more than illustrate and be only preferred embodiment of the present invention; the present invention is not limited to enumerate above-described embodiment; should be noted that; any those of ordinary skill in the art are under the instruction of this description; made all equivalently to substitute, obvious variant, within the essential scope all dropping on this description, protection of the present invention ought to be subject to.

Claims

1., for a hypertensive medicine, it comprises following component according to weight portion:

2. medicine according to claim 1, is characterized in that, it comprises following component: