CN105232746A - Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating thoracic wall contusion and rib fracture and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating thoracic wall contusion and rib fracture and a preparation method of the traditional Chinese medicine preparation and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises, by weight, 3-15 parts of Chinese thorowax root, 6-12 parts of semen persicae, 3-9 parts of safflower, 6-15 parts of radix angelicae sinensis, 3-12 parts of Szechuan lovage rhizome, 6-12 parts of red peony root, 6-15 parts of twotooth achyranthes root, 3-15 parts of Danshen root, 6-9 parts of fructus aurantii, 3-10 parts of platycodon root, 6-15 parts of rhizoma corydalis, 2-12 parts of costustoot, 3-6 parts of liquorice and 6-15 parts of dried rehmannia root. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is capable of promoting blood circulation to remove blood stasis while promoting qi circulation to disperse depressed emotion, eliminating phlegm while nourishing blood to avoid blood consumption during blood circulation promoting and impairment of yin during qi circulation promoting, and elevating yang while rushing down to descend to enable qi and blood to be harmonious; the traditional Chinese medicine composition is quite low in cost and exact in treatment effect when being used for treating thoracic wall contusion and rib fracture gall symptoms.

Description

A traditional Chinese medicine composition, traditional Chinese medicine preparation and preparation method thereof for treating chest wall contusion and rib fracture

technical field

The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating chest wall contusion and rib fracture, a traditional Chinese medicine preparation and a preparation method thereof.

Background technique

Chest wall contusion and rib fracture are common emergencies in TCM orthopedic surgery. Chest wall contusion is often caused by violence on the chest and hypochondrium, resulting in soft tissue damage, poor circulation of Qi and blood, and pain due to stagnation of Qi. Traditional Chinese medicine believes that the chest is the division of the lungs. The pulse of the liver meridian runs from bottom to top to the ribs, and the pulse of the gallbladder meridian runs from top to bottom through the chest ribs. The lungs govern qi and the liver stores blood. Qi and blood travel together in the chest, and the qi runs through the chest cavity , the movement of qi is reversed, the lungs lose their vibrancy, the stagnation of qi is unsmooth, and blood stasis is difficult to circulate. All yang receive qi in the chest. into phlegm.

Rib fractures are the most common in chest trauma, and they are mostly caused by falls, impacts, traffic accidents and other violence directly acting on the ribs, especially in the elderly who are prone to osteoporosis and those with bone metastasis of malignant tumors are prone to pathological fractures. Traditional Chinese medicine believes that ribs are easily injured, and chest wall swelling and pain after injury are caused by fractures and tendon injuries, damaged meridians, blood overflowing outside the veins, stasis under the ribs, and blockage of Qi. "Qi hurts pain", "shape hurts swelling". Inside the sternal ribs are the lungs, and severe injuries to the sternal ribs will inevitably affect the respiratory function of the lungs. This is mostly due to stagnation of qi and blood, which makes the airway unsmooth, the lungs are not cleared, and the qi is reversed and the qi is not smooth. If the blood stasis accumulates in the lower body, it will also cause the liver to lose its balance, which will injure the lung metal, resulting in wheezing and coughing. For example, after chest injury, blood stasis builds up heat, and lung qi is damaged after injury, and wind, phlegm, and blood stasis stagnate and turn into fire, which will also lead to continuous coughing and choking. After the injury, the six exogenous evils take advantage of the deficiency and cause lung dysfunction, wheezing, coughing and dyspnea.

At present, the principles of treatment for chest wall contusion and rib fracture are based on effective pain control, pulmonary physical therapy and early mobilization. In the early stage (within 10 days of injury), thoracic rib swelling and pain at the injured site, local ecchymosis, refusal to press, aggravated by deep breathing, coughing and sneezing, severe cases dare not speak loudly, and dyspnea . Dark red tongue, or ecchymosis, thin white fur, stringy or rapid pulse. It is suitable for promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is useful to add or subtract Fuyuan Huoxue Decoction to remove the blood stasis and regenerate the blood, and the circulation of qi to unblock the collaterals, so that the hypochondriac pain will stop itself. In the mid-term (after 10 days of injury), the pain was relieved, but it was still more painful when taking a deep breath and coughing, with refusal to press, dark red tongue, thin white fur, and stringy pulse. It is suitable for promoting blood circulation and promoting qi, soothing the liver and relieving pain. Recipe with Bupleurum Shugan powder addition and subtraction. In the later stage (6-8 weeks after injury), the fractures are generally healed, but there may still be dull pain in the ribs, chest tightness, and throbbing pain when coughing and expectoration, pale red tongue, thin white fur, and thready pulse. Nourish the liver and kidney, nourish qi and blood, supplemented by promoting qi and blood. Addition and subtraction of Xugu Huoxue Decoction. Most of them are based on promoting blood circulation and removing blood stasis, supplemented by nutrition, but the therapeutic effect is limited. There are few formulas of traditional Chinese medicine for treating chest wall contusion and rib fracture, and most traditional Chinese medicines use peony, Chuanxiong, chrysanthemum and other wind-removing medicines as the main formula.

In the prior art, CN1623588A "A Traditional Chinese Medicine Composition for Treating Fractures and Soft Tissue Injuries" discloses a Chinese medicine composition comprising the following components: Hematoxylin 7-30, Safflower 3-12, Peach Kernel 3-12, Angelica 4 -18, Chuanxiong 3-12, Chishao 5-20, Rehmannia 5-20, Frankincense 6-25, Myrrh 6-25, Eucommia 6-25, Sanleng 5-20, Curcuma 5-20, Guizhi 4- 18. Achyranthes bidentata 4-18, Alisma 5-20, paeonol 3-12. The traditional Chinese medicine composition has the effects of relaxing tendons and activating blood circulation, harmonizing and dredging collaterals, dissipating blood stasis and dispelling pain. However, it is not effective for the treatment of chest wall contusion and rib fracture.

Contents of the invention

The first object of the present invention is to provide a traditional Chinese medicine composition for treating chest wall contusion and rib fracture. The Chinese medicine composition has low cost and definite curative effect for treating chest wall contusion and rib fracture swelling and pain.

The second object of the present invention is to provide a Chinese medicine preparation for treating chest wall contusion and rib fracture.

The third object of the present invention is to provide a preparation method of the above-mentioned traditional Chinese medicine preparation for treating chest wall contusion and rib fracture.

For realizing above object, the technical scheme that the present invention adopts is:

A traditional Chinese medicine composition for treating chest wall contusion and rib fracture, which consists of the following components in parts by weight: 3-15 parts of Bupleurum bupleurum, 6-12 parts of peach kernel, 3-9 parts of safflower, 6-15 parts of angelica tail 3-12 parts of Chuanxiong, 6-12 parts of Radix Paeoniae Rubra, 6-15 parts of Achyranthes bidentata, 3-15 parts of Salvia miltiorrhiza, 6-9 parts of Citrus aurantium, 3-10 parts of platycodon grandiflorum, 6-15 parts of Corydalis 6-15, woody 2 ~12 parts, 3~6 parts of licorice, 6~15 parts of raw land.

Preferably, a traditional Chinese medicine composition for treating chest wall contusions and rib fractures consists of the following components in parts by weight: 15 parts of Bupleurum bupleuri, 12 parts of peach kernels, 9 parts of safflower, 9 parts of angelica tail, and 12 parts of Chuanxiong , 12 parts of red peony root, 12 parts of Achyranthes bidentata, 12 parts of salvia miltiorrhiza, 9 parts of Citrus aurantii, 10 parts of bellflower, 15 parts of yanhusuo, 12 parts of woody fragrance, 6 parts of licorice, and 12 parts of raw land.

In the Chinese medicine composition of the present invention, the properties and efficacy of each component Chinese medicine are as follows:

Bupleurum: the root of Bupleurum or Bupleurum angustifolia of the genus Bupleurum in the Umbelliferae family; contains volatile oils such as o-methoxyphenol, enantholactone, capryllactone, decanolactone, eugenol, undecanoic acid It also contains saponins such as saikosaponin, acetyl saikosaponin, flavonoids such as rutin, quercetin and other active ingredients. Bitter, pungent, slightly cold, returns to the liver and gallbladder meridian; the effect is to relieve the exterior and reduce fever, soothe the liver and relieve stagnation, and elevate yang qi; it is mainly used to treat fever caused by exogenous factors, alternating cold and heat, malaria, liver stagnation, hypochondriac pain, breast distension, headache, dizziness, Irregular menstruation, prolapse of the anus, prolapse of the uterus, and gastroptosis due to qi deficiency. Modern pharmacological studies have shown that Bupleurum has anti-inflammatory, antipyretic, sedative, analgesic, antitussive, liver-protecting, stomach-protecting, blood-lipid-lowering, anti-bacterial, anti-viral, anti-tumor, and metabolism-promoting effects.

Peach kernel: It is the seed of peach or mountain peach, a plant belonging to the family Rosaceae; it contains amygdalin, prunin, sterols, organic acids, protein and other active ingredients. Bitter in nature, sweet, flat, Guixin, Liver, Large Intestine Channel. Efficacy is promoting blood circulation and removing blood stasis, moistening bowel and defecating; mainly treating dysmenorrhea, amenorrhea due to stagnation of blood, postpartum stagnant abdominal pain, lumps in the abdomen, bruises, congestion, swelling and pain, lung abscess, intestinal abscess, intestinal dryness and constipation. Modern pharmacological research shows that peach kernel has the functions of promoting circulatory system function, anticoagulation and antithrombotic, anti-inflammatory, cough and expectorant, anti-tumor and so on.

Safflower: It is the flower of safflower of the genus Safflower in the Compositae family; it contains flavonoids such as safflower glycosides, prosafflower glycosides, safflower yellow pigment, and safflower glycosides, as well as chlorogenic acid, caffeic acid, and verbene Active ingredients such as ketones and 16 kinds of amino acids. Spicy, warm, heart-guiding, liver meridian; effects of promoting blood circulation, dispelling blood stasis and relieving pain; mainly treating blood stasis amenorrhea, dysmenorrhea, postpartum abdominal pain due to blood stasis, chest obstruction and heart pain, accumulation of lumps, bruises, joint pain, stroke and hemiplegia , macula. Modern pharmacological studies have shown that safflower has the functions of enhancing cardiovascular system function, anticoagulation, lowering blood fat, enhancing hypoxia tolerance, immune activity and anti-inflammation.

Angelica tail: the tail of the traditional Chinese medicine Angelica sinensis; the surface is yellowish brown to tan, with longitudinal wrinkles and horizontally long lenticels, with ring patterns. It has the effect of promoting blood circulation and removing blood stasis, and can treat the symptoms of amenorrhea and stagnant swelling and pain due to congestion.

Ligusticum Chuanxiong: It is the rhizome of Ligusticum chuanxiong in Umbelliferae; it contains ligustrazine, loline, chuanxiongdole, ligustilide, chuanxiong nafurolide and other lactones, as well as phenolic acids, volatile oils, etc. Various active ingredients. Hot and warm in nature, it returns to the liver, gallbladder and pericardium meridian; the effect is to promote blood circulation and remove blood stasis, promote qi circulation to relieve stagnation, dispel wind and relieve pain; it is mainly used to treat irregular menstruation, amenorrhea dysmenorrhea, postpartum stagnant abdominal pain, lumps in the abdomen, chest and hypochondriac pain, Headache and dizziness, wind-cold-damp arthralgia, bruises, carbuncle sores. Modern pharmacological studies have shown that Rhizoma Chuanxiong can enhance the function of the cardiovascular system (such as dilating blood vessels, inhibiting high blood pressure, resisting myocardial ischemia and reperfusion injury, and protecting against cerebral ischemia, etc.), enhancing blood system function, enhancing urinary and immune function System function, anti-tumor, anti-radiation and other effects.

Radix Paeoniae Rubra: It is the root of Radix Paeoniae Rubra and Radix Paeoniae Rubra, containing monoterpenoids such as paeoniflorin, organic acids such as benzoic acid, gallic acid, catechin, sitosterol and other active ingredients. Bitter in nature, slightly cold; Return liver, spleen meridian. Efficacy is clearing away heat and cooling blood, promoting blood circulation and removing blood stasis; mainly treating warm toxins and spots, vomiting blood and epistaxis, intestinal wind and blood, red eyes and swelling pain, carbuncle sores, amenorrhea, dysmenorrhea, metrorrhagia and stranguria, stasis and hypochondriac pain, hernia Lump accumulation, injury from falling. Modern pharmacological studies have shown that Radix Paeoniae Rubra has anti-thrombosis, anti-platelet aggregation, anti-arteriosclerosis, promotion of cardiovascular system function, anti-tumor, liver protection and other effects.

Achyranthes bidentata: It is the root of Achyranthes bidentata in the family Amaranthaceae; it contains triterpenoid saponins such as achyranthes saponins, ginsenosides, and bamboo ginseng saponins, as well as polysaccharides, sterones, amino acids, proteins and other active ingredients. Bitter, sour, flat, returns to the liver and kidney meridian; the effect is to nourish the liver and kidney, strengthen the bones and muscles, promote blood circulation and stimulate the menstrual flow, induce blood (fire) to descend, diuresis and relieve stranguria; mainly treat waist and knee pain, flaccidity and softness of lower limbs, amenorrhea due to stagnation of blood , Dysmenorrhea, postpartum blood stasis, abdominal pain, lump in the abdomen, retained clothes, hot stranguria, stranguria with blood, bruises, carbuncle, malignant sore, sore throat. Modern pharmacological studies have shown that Achyranthes bidentata has the functions of analgesia and anti-inflammation, improving cardiovascular and respiratory system functions, anti-fertility, lowering blood sugar, improving immune system functions, delaying aging and anti-tumor. In the traditional Chinese medicine composition of the present invention, the Achyranthes bidentata is Chuan Achyranthes bidentata.

Salvia miltiorrhiza: the root of Salvia miltiorrhiza in the Lamiaceae family; it contains quinone compounds such as tanshinone, tanshinone lactone, cryptotanshinone, and isotanshinone, as well as water-soluble phenolic compounds such as salvianolic acid and protocatechualdehyde and other active ingredients. Bitter in nature, slightly cold, Guixin, Baoxin, Liver Meridian; the effect is promoting blood circulation and dispelling blood stasis, regulating menstruation and relieving pain, relieving restlessness and tranquilizing the nerves, cooling blood and eliminating carbuncle; mainly treating women's irregular menstruation, dysmenorrhea, amenorrhea, postpartum stagnant abdominal pain, trusted subordinate's pain, Accumulation of lumps in the abdomen, heat numbness and pain, bruises, heat entering the camp and blood, irritability, upset and insomnia, carbuncle and sore swelling. Modern pharmacological research shows that Salvia miltiorrhiza can enhance the function of cardiovascular and cerebrovascular systems, lower blood fat and resist atherosclerosis, anticoagulant and antithrombotic, resist hypoxia, enhance immune system function, anti-inflammation and anti-allergy, protect liver and liver, Anti-gastric ulcer, improve kidney function and anti-oxidation effects.

Fructus aurantium: the immature fruit of sour orange and its cultivars of the citrus plant of Rutaceae; it contains flavonoids such as hesperidin, alkaloids, limonoids and other active ingredients; it is bitter, sour, warm, and returns to the lungs and spleen , stomach, large intestine channel. The efficacy is to regulate qi and broaden the chest, stagnant movement and eliminate stagnation; it mainly treats soreness in the chest and diaphragm, distending pain in the flanks, inability to dissolve food accumulation, fullness in the abdomen, heavy diarrhea after diarrhea, and uterine prolapse. Modern pharmacological studies have proved that Fructus Aurantii has the functions of enhancing cardiovascular system and promoting gastrointestinal function.

Platycodon grandiflorum: the root of Platycodon grandiflorum, a plant of the genus Campanulaceae, containing platycodon saponins, saponins, sterols and other active ingredients. Bitter in the mouth, flat in nature, returns lung meridian. It has the effect of opening lung qi, eliminating phlegm and discharging pus. For the treatment of exogenous cough, sore throat, lung abscess, spitting, chest fullness and hypochondriac pain, dysentery and abdominal pain and other diseases. "Pearl Sac" records: "passing with licorice is an agent for boats". Platycodon grandiflorum has many pharmacological effects, among which the regulation of macrophages is the most important part, and it is one of the mechanism of action of platycodon grandiflorum for anti-inflammation, anti-tumor and anti-pathogenic microorganisms.

Corydalis Corydalis: the tuber of Corydalis Corydalis in the family Papaveraceae; it contains alkaloids such as cordyline, protopine, and tetrahydro-bertisine. Pungent, bitter, and warm in nature, it returns to the Liver, Stomach, Heart, Lung, and Spleen Channels. Efficacy is promoting blood circulation, dispelling blood stasis, regulating qi, and relieving pain; mainly treating confidants' waist and knee pain, irregular menstruation, lump in the abdomen, metrorrhagia, postpartum haemorrhage, lochia, and bruises. Modern pharmacological studies have proved that Yanhusuo has the functions of analgesia, hypnosis, sedation, stability, anti-tumor, promotion of digestive system function, and promotion of cardiovascular system function.

Muxiang: a synonym of Guangmuxiang, which is the root of the plant Muxiang in the family Asteraceae; the root oil contains active ingredients such as lactone compounds, volatile components, and various amino acids; it is pungent, bitter, warm, and returns to the spleen , stomach, liver, lung meridian. Efficacy is promoting qi and relieving pain, regulating the middle and guiding stagnation; mainly treating fullness in the chest and hypochondrium, abdominal distension and pain, vomiting and diarrhea, and post-dysentery. Modern pharmacological studies have proved that woody incense has the effects of promoting the gastrointestinal tract, lowering blood pressure, anti-inflammatory, analgesic, and lowering blood sugar.

Licorice: the roots and rhizomes of Glycyrrhiza glabra, Glycyrrhizae glabra, and Glycyrrhiza inflate; it contains various active ingredients such as triterpenoid saponins, flavonoids, coumarins, alkaloids and polysaccharides; sweet, Flat, returns spleen, stomach, heart, lung channel. Efficacy is to neutralize the emergency, moisturize the lungs, detoxify, and reconcile various medicines; it is mainly used to treat weakness of the spleen and stomach, fatigue, lack of food, abdominal pain and loose stools, acute pain in the limbs, palpitations, dryness of the lungs, lung flaccidity and cough, sore throat, carbuncles, swollen toxins, Fetal poisoning in children and drug and food poisoning. Modern pharmacological studies have proved that licorice has antimicrobial, improving cardiovascular system function, promoting digestion, protecting liver, anti-inflammatory, analgesic, expectorant, improving immune system function, anti-tumor, anti-mutation, detoxification, and anti-oxidation.

Habitat: the root of Radix Rehmanniae of Scrophulariaceae; sweet, cold, Guixin, Liver, Kidney meridians. Contains effective ingredients such as sitosterol and mannitol, rehmanthin, alkaloids, fatty acids, glucose and vitamin A. It has the effects of clearing away heat and cooling blood, benefiting yin and promoting body fluid, and is used for febrile diseases with heat entering the camp and blood, strong heat, dizziness, dry mouth and tongue.

In the traditional Chinese medicine composition of the present invention, peach kernel, dispels blood stasis, moistens dryness and smooths intestines; safflower, promotes blood circulation and stimulates menstrual flow, dispels blood stasis and relieves pain; Angelica tail, promotes blood circulation and relieves pain, laxes bowels, nourishes blood and regulates menstruation; Chuanxiong, promotes blood circulation and promotes Qi , expelling wind and relieving pain; red peony root, promoting blood circulation and regulating menstruation, dispelling blood stasis and relieving pain, clearing liver and improving eyesight, eliminating carbuncle and dissipating swelling; Blood stasis, promoting blood circulation to reduce swelling, nourishing blood to calm the nerves. Platycodon grandiflorum, clearing lung and eliminating phlegm, relieving sore throat and relieving pain, draining pus and eliminating carbuncle; Licorice root, invigorating the middle and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain. Corydalis Corydalis, promoting blood circulation and promoting qi to relieve pain; Bupleurum, expelling heat from the surface, soothing the liver and relieving stagnation, raising yang and lifting depression, used for reducing fever; woody fragrance, promoting qi and relieving pain, invigorating the stomach and eliminating food. Citrus aurantium, dispels qi and eliminates stagnation, lowers qi and laxative; Shengdi, clears heat and cools blood, cools blood to stop bleeding, nourishes yin and promotes body fluid. Combined use of various medicines, promoting blood circulation and promoting qi together, not only promoting blood stasis, but also relieving stagnation of qi; expelling phlegm and nourishing blood at the same time, promoting blood circulation without worrying about blood consumption, promoting qi without harming yin, and taking care of ascending and descending , it can not only ascend to Qingyang, but also assist in descending and venting, so as to harmonize Qi and blood.

The traditional Chinese medicine composition for the treatment of chest wall contusion and rib fracture of the present invention uses Bupleurum chinensis, peach kernel, safflower, angelica tail, chuanxiong, red peony root, achyranthes bidentata, salvia miltiorrhiza, aurantium aurantii, platycodon grandiflorum, corydalis, woody fragrance, licorice, The combination of 14 traditional Chinese medicines of Shengdi has a reasonable formula. The peach kernel and safflower used in the formula are the king, the red peony root and Chuanxiong are the king, and the achyranthes bidentata is the minister. It can improve the symptoms of chest wall contusion and rib fracture swelling and pain. The components of Bupleuri are compatible to regulate qi and promote stagnation, soothe the liver and relieve stagnation, and achieve the purpose of comprehensive conditioning and treating both symptoms and root causes; the raw materials of traditional Chinese medicine used in the formula have a wide range of sources and low cost, and are effective in treating chest wall contusion and rib fracture.

A traditional Chinese medicine preparation for treating chest wall contusion and rib fracture, mainly made of the following raw materials in parts by weight: 3-15 parts of Bupleurum bupleurum, 6-12 parts of peach kernel, 3-9 parts of safflower, 6-15 parts of angelica tail 3-12 parts of Chuanxiong, 6-12 parts of Radix Paeoniae Rubra, 6-15 parts of Achyranthes bidentata, 3-15 parts of Salvia miltiorrhiza, 6-9 parts of Citrus aurantium, 3-10 parts of platycodon grandiflorum, 6-15 parts of Corydalis 6-15, woody 2 ~12 parts, 3~6 parts of licorice, 6~15 parts of raw land.

Preferably, a traditional Chinese medicine preparation for treating chest wall contusion and rib fracture is mainly made of the following raw materials in parts by weight: 15 parts of Bupleurum bupleuri, 12 parts of peach kernel, 9 parts of safflower, 9 parts of angelica tail, and 12 parts of Chuanxiong , 12 parts of red peony root, 12 parts of Achyranthes bidentata, 12 parts of salvia miltiorrhiza, 9 parts of Citrus aurantii, 10 parts of bellflower, 15 parts of yanhusuo, 12 parts of woody fragrance, 6 parts of licorice, and 12 parts of raw land.

The traditional Chinese medicine preparation is powder, capsule, decoction or pill. The dosage form of the traditional Chinese medicine preparation is powder, capsule, decoction or pill prepared according to the requirements of the Chinese Pharmacopoeia 2010 edition; preferably decoction.

A preparation method of the above-mentioned traditional Chinese medicine preparation for treating chest wall contusion and rib fracture, comprising: taking raw materials according to the formula, adding water for decoction twice, and combining the decoctions to obtain the decoction.

In the above preparation method, the raw material medicine is placed in a container, water is added until the water surface is 3-5cm higher than the medicine surface, the fire is first boiled, then the fire is changed to a simmer, and after boiling for 20 minutes, the decoction is obtained by filtering; water is added for the second decoction (specific operation Same as above), combined two decoctions to obtain decoction.

When the decoction is taken, one dose per day, 450-550 ml per dose, is taken after meals in 2-3 times, and 10-15 days is a course of treatment.

A preparation method of the above-mentioned traditional Chinese medicine preparation for treating chest wall contusion and rib fracture, comprising: taking raw materials according to the formula, pulverizing them into fine powders of 100-150 mesh, preparing powders or packing them into capsules to obtain capsules.

A kind of preparation method of above-mentioned Chinese medicine preparation for the treatment of chest wall contusion, rib fracture, comprises the following steps:

1) Measure raw materials according to the formula, crush and sieve, sterilize to obtain powder;

2) According to the mass ratio of powder and honey in the ratio of 100:30, mix the powder and honey, heat it to 65-75°C and mix it with boiling water evenly, refine it for 3 times, make it into a pellet, and then dry it to get honey pill.

In step 1), the sieving refers to passing through a 100-150 mesh sieve.

In step 1), the sterilization is at 100° C. for 30 minutes.

In step 2), the drying temperature is 55-65°C.

The said refining 3 times refers to that a part of the medicine powder is first bonded into a ball core with a size of 0.5-1.0mm (moulding), then the obtained ball core is put into the medicine powder, shaken and enlarged to make a middle pill (molding), and finally the middle pill is made into a ball core. The size of the finished product makes the surface of the pill dense, smooth and consistent in color (cover).

The traditional Chinese medicine preparation for the treatment of chest wall contusion and rib fracture of the present invention mainly consists of Bupleurum chinensis, peach kernel, safflower, angelica tail, chuanxiong, red peony root, achyranthes bidentata, salvia miltiorrhiza, citrus aurantium, platycodon grandiflorum, corydalis, woody fragrance, licorice, Shengdi is made from 14 traditional Chinese medicines and can be used as powder, capsule, decoction or pill. It is effective in treating chest wall contusion and rib fracture. Among them, the decoction is easy to operate; the powder and capsule are easy to make, low in cost, and convenient for storage and transportation; the pill is a honeyed pill, which has better compliance when taken by patients, simple process, low cost, and is suitable for large-scale industrial production. .

detailed description

The present invention will be further described below in conjunction with specific examples.

Example 1

The traditional Chinese medicine composition for the treatment of chest wall contusion and rib fracture in this embodiment consists of the following components by weight: Bupleurum bupleuri 15g, peach kernel 12g, safflower 9g, angelica tail 9g, chuanxiong 12g, red peony root 12g, achyranthes bidentata 12g , Salvia 12g, Citrus aurantium 9g, Bellflower 10g, Corydalis 15g, Woody 12g, Licorice 6g, Habitat 12g.

The traditional Chinese medicine preparation for treating chest wall contusion and rib fracture in this embodiment is a decoction, which is mainly made of the above-mentioned traditional Chinese medicine composition. The preparation method comprises: taking the traditional Chinese medicine composition according to the formula and placing it in a sand pot, adding water to make the water surface 3cm higher than the medicinal surface, boiling with a strong fire and switching to a slow fire for 20 minutes, and filtering to obtain a decoction; adding water to the filter residue, making the water surface 3cm higher than the medicinal surface, After boiling, switch to simmering for 20 minutes, filter the second decoction, and combine the two decoctions to obtain the decoction.

When the decoction is taken, one dose per day, 450-550 ml per dose, is taken after meals in 2-3 times, and 10 days is a course of treatment.

Example 2

The traditional Chinese medicine composition for the treatment of chest wall contusion and rib fracture in this example consists of the following components by weight: Bupleurum bupleuri 3g, peach kernel 12g, safflower 9g, angelica tail 9g, chuanxiong 6g, red peony 6g, and achyranthes bidentata 9g , Salvia 12g, Citrus aurantium 6g, Bellflower 5g, Corydalis 15g, Woody 10g, Licorice 6g, Habitat 9g.

The traditional Chinese medicine preparation for treating chest wall contusion and rib fracture in this embodiment is a powder made from the above-mentioned traditional Chinese medicine composition. The preparation method is as follows: measure the traditional Chinese medicine composition according to the formula, grind it into 120-mesh fine powder, and prepare the powder. Alternatively, the obtained fine powder is packed into capsules to obtain capsules.

The taking method of the capsule is: 2-4g each time, three times a day.

Example 3

The traditional Chinese medicine composition for treating chest wall contusion and rib fracture in this embodiment consists of the following components by weight: Bupleurum bupleuri 3g, peach kernel 12g, safflower 9g, angelica tail 9g, chuanxiong 9g, red peony root 9g, achyranthes bidentata 12g , Salvia 9g, Citrus aurantium 6g, Bellflower 6g, Corydalis 12g, Woody 12g, Licorice 6g, Habitat 6g.

The Chinese medicine group preparation for treating chest wall contusion and rib fracture in this embodiment is a pill, which is mainly made of the above-mentioned Chinese medicine composition. The preparation method comprises the following steps:

1) Measure the above-mentioned traditional Chinese medicine composition according to the formula, crush it and pass it through a 120-mesh sieve, and then sterilize it at 100°C for 30 minutes to obtain a powder;

2) According to the mass ratio of the powder and the honey in the ratio of 100:30, mix the powder and the honey, heat it to 70°C, mix it with boiling water evenly, and make it into a pellet with a weight of 0.3g after scouring for 3 times. Dry at 60°C to obtain honeyed pills.

The taking method of the honeyed pill is: 3-6g each time, twice a day.

Table 1 shows the formulations of the traditional Chinese medicine compositions used in the treatment of chest wall contusions and rib fractures in Examples 4-8.

The formula of the Chinese medicine composition of table 1 embodiment 4-8

The traditional Chinese medicine preparation for the treatment of chest wall contusion and rib fracture of embodiment 4-8 can be decoction, powder (or capsule), pill, and the preparation method of each preparation is respectively the same as embodiment 1, embodiment 2 or embodiment 3.

The clinical trial results are as follows:

(1) General Information

All chest wall contusions and rib fractures are selected as mild and moderate surgical patients, excluding severe patients, pregnant women, patients with a history of severe gastroduodenal ulcer, and those with severe brain, liver, kidney and other organ lesions, and those with yin deficiency and hyperactivity of fire , people with deficiency in the upper part and weak Qi in the lower part. A total of 61 cases were selected, including 32 males and 29 females, aged 40 to 75 years. Among the 61 selected cases, 55 cases were chest wall contusions and rib fractures caused by violent trauma, and 6 cases were caused by external force and senile osteoporosis.

(2) Research methods

The 61 selected patients were divided into two groups, 31 cases in the treatment group and 30 cases in the control group.

The treatment group took the decoction made from the traditional Chinese medicine composition of Example 1 of the present invention, twice a day, one dose a day, after meals.

The control group was given drugs to relieve pain and nutritional drugs to promote recovery: drugs to promote blood circulation and remove blood stasis, and oral Shangke Dieda pills once a day.

During the treatment period, other medical diseases in the two groups can continue to be treated as usual. 15 days is a course of treatment.

(3) Judgment criteria for curative effect

Cured: chest wall contusion and rib fracture healed; markedly effective: symptoms of chest wall contusion and rib fracture were significantly relieved; effective: symptoms of chest wall contusion and rib fracture improved; ineffective: chest wall contusion and rib fracture did not improve.

(4) Research results

After 90 days of treatment, the curative effect comparison results of the two groups are shown in Table 2.

Table 2 Comparison of the curative effects of the two groups

group Number of cases cure markedly effective efficient invalid Total effective rate (%) therapy group 31 twenty four 3 2 2 93.54 control group 30 10 6 4 10 66.67

(5 Conclusion

After 30 days of treatment, the total effective rate of chest wall contusion and rib fracture in the treatment group was 93.54%, which was significantly higher than 66.67% in the control group (P<0.01). Experimental results show that the traditional Chinese medicine composition of the invention has significant curative effect on chest wall contusion and rib fracture. Taking the traditional Chinese medicine composition of the present invention has no adverse reactions such as liver and kidney function damage, indicating that the traditional Chinese medicine composition of the present invention has better safety.

The patients with chest wall contusion and rib fracture of Experimental Examples 2-8 took the capsules, decoctions or honeyed pills of Embodiments 2-8 respectively in turn. The specific experimental method was the same as that of Experimental Example 1. The therapeutic effect is shown in Table 2:

Table 2 Comparative results of experimental examples 2 to 8 curative effects

Conclusion: After 20 days of treatment, the total effective rate of chest wall contusion and rib fracture in the treatment group was 78.95-89.74%, significantly higher than that of the control group (60.00-65.71% (P<0.01). Experimental results show that the Chinese medicine composition of the present invention has significant curative effect on chest wall contusion and rib fracture; adverse reactions such as liver and kidney function damage do not occur after taking the Chinese medicine composition of the present invention, showing that the Chinese medicine composition of the present invention has better safety .

Typical cases

Typical case 1: Mr. Zhao, 55 years old, from Foshan City, Guangdong Province, had a rib fracture, and the treatment of traditional Chinese medicine such as Panax notoginseng preparation for promoting blood circulation and removing blood stasis was ineffective. He took the traditional Chinese medicine combination of Example 4 of the present invention twice a day at the same time as conventional surgical treatment After 30 days of taking the decoction made from the decoction, the symptoms of rib fractures improved, and after taking it for 90 days, the rib fractures healed.

Typical case 2: Ms. Liu from Yiyang County, Henan Province, 48 years old, suffered from chest wall contusion. The therapeutic effects of acupuncture and moxibustion, traditional Chinese medicine for promoting blood circulation and removing blood stasis were poor. She took the traditional Chinese medicine composition of Example 5 of the present invention twice a day. The decoction of chest wall contusion symptoms improved after 20 days.

Typical case 3: Mr. Zhang, 61 years old, from Gaoming City, Guangdong Province, suffered a rib fracture. The treatment of traditional Chinese medicine such as Panax notoginseng preparation for promoting blood circulation and removing blood stasis was ineffective. At the same time of conventional surgical treatment, he took 2-4g each time, 3 times a day, using the present invention After 30 days of capsules made from the traditional Chinese medicine composition of Example 2, the rib fracture symptoms improved, and the rib fracture healed after taking it for 90 days.

Typical case 4: Mr. Tian, 70 years old, from Luoyang City, Henan Province, suffered chest wall contusion, and the curative effect was poor after acupuncture, traditional Chinese medicine for promoting blood circulation and removing blood stasis. In addition to conventional treatment, he took 2-4g each time, 3 times a day, and adopted the present invention After 20 days of capsules made from the traditional Chinese medicine composition of Example 6, the symptoms of chest wall contusion were significantly improved.

Typical case 5: Ms. Li, Nanning City, Guangxi Province, 55 years old, suffered a rib fracture, and her treatment of promoting blood circulation and removing blood stasis with traditional Chinese medicine such as Panax notoginseng preparation was ineffective. At the same time of routine surgical treatment, 3-6g each time, twice a day, used the present invention After 30 days of the pill made from the traditional Chinese medicine composition of Example 3, the rib fracture symptoms improved, and the rib fracture healed after taking it for 90 days.

Typical case 7: Ms. Wang, Kaifeng City, Henan Province, 60 years old, contusion of the chest wall, taking traditional Chinese medicine to promote blood circulation and remove blood stasis was ineffective, 3-6g each time, twice a day to take the pill made of the traditional Chinese medicine composition of Example 7 of the present invention After 20 days, symptoms of chest wall contusion improved.

Claims (10)

1. A traditional Chinese medicine composition for treating chest wall contusion and rib fracture, characterized in that: it consists of the following components in parts by weight: 3 to 15 parts of Bupleurum bupleuri, 6 to 12 parts of peach kernel, and 3 to 9 parts of safflower , Angelica tail 6-15 parts, Chuanxiong 3-12 parts, Chishao 6-12 parts, Achyranthes bidentata 6-15 parts, Salvia miltiorrhiza 3-15 parts, Citrus aurantium 6-9 parts, Campanulaceae 3-10 parts, Corydalis 6-6 parts 15 parts, woody 2-12 parts, licorice 3-6 parts, raw ground 6-15 parts. 2. The traditional Chinese medicine composition for treating chest wall contusion and rib fracture according to claim 1, characterized in that: it consists of the following components in parts by weight: 15 parts of Bupleurum, 12 parts of peach kernel, 9 parts of safflower, 9 parts of angelica tail, 12 parts of Chuanxiong, 12 parts of red peony root, 12 parts of Achyranthes bidentata, 12 parts of salvia miltiorrhiza, 9 parts of Citrus aurantium, 10 parts of bellflower, 15 parts of Corydalis, 12 parts of woody fragrance, 6 parts of licorice, and 12 parts of raw land. 3. A traditional Chinese medicine preparation for treating chest wall contusion and rib fracture, characterized in that it is mainly made of the following raw materials in parts by weight: 3-15 parts of Bupleurum bupleurum, 6-12 parts of peach kernel, and 3-9 parts of safflower , Angelica tail 6-15 parts, Chuanxiong 3-12 parts, Chishao 6-12 parts, Achyranthes bidentata 6-15 parts, Salvia miltiorrhiza 3-15 parts, Citrus aurantium 6-9 parts, Campanulaceae 3-10 parts, Corydalis 6-6 parts 15 parts, woody 2-12 parts, licorice 3-6 parts, raw ground 6-15 parts. 4. The Chinese medicine preparation for treating chest wall contusion and rib fracture according to claim 3, characterized in that: said Chinese medicine preparation is powder, capsule, decoction or pill. 5. a preparation method for treating chest wall contusion and rib fracture as claimed in claim 4, characterized in that: comprising measuring raw materials according to the formula, decocting with water twice, merging the decoction, and obtaining the soup agent. 6. A preparation method for treating chest wall contusions and rib fractures as claimed in claim 4, characterized in that it comprises measuring the raw materials according to the formula and pulverizing them into fine powders of 100-150 mesh to prepare powder or Pack capsules to obtain capsules. 7. a preparation method for treating chest wall contusion, rib fracture as claimed in claim 4, is characterized in that, comprises the following steps: 1) Measure raw materials according to the formula, crush and sieve, sterilize to obtain powder; 2) According to the mass ratio of powder and honey in the ratio of 100:30, mix the powder and honey, heat it to 65-75°C and mix it with boiling water evenly, refine it for 3 times, make it into a pellet, and then dry it to get honey pill. 8. The preparation method of the traditional Chinese medicine preparation for treating chest wall contusion and rib fracture according to claim 7, characterized in that: in step 1), the sieving refers to passing through a 100-150 mesh sieve. 9. The preparation method of the traditional Chinese medicine preparation for treating chest wall contusion and rib fracture according to claim 7, characterized in that: in step 1), the sterilization is at 100° C. for 30 minutes. 10. The preparation method of the traditional Chinese medicine preparation for treating chest wall contusion and rib fracture according to claim 7, characterized in that: in step 2), the drying temperature is 55-65°C.