CN105173421B - Sterile drug delivery system for multi-dose eye drops - Google Patents
Sterile drug delivery system for multi-dose eye drops Download PDFInfo
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- CN105173421B CN105173421B CN201510592089.XA CN201510592089A CN105173421B CN 105173421 B CN105173421 B CN 105173421B CN 201510592089 A CN201510592089 A CN 201510592089A CN 105173421 B CN105173421 B CN 105173421B
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Abstract
The invention discloses a sterile drug delivery system for multi-dose eye drops. The sterile drug delivery system comprises a bottle, a bottom cover and a pressing mechanism. The bottle comprises an outer bottle body, an inner bottle body and a dust cover. A stifle mechanism is arranged on the inner bottle body, and the outer bottle body is provided with a sprayer system. The stifle mechanism and the sprayer system are connected through a piston connecting rod mechanism. The pressing mechanism comprises a bottle sleeve, an arc opening and a pressing block. A push block is arranged at the bottom of the bottle sleeve and provided with a first inclined face. The pressing block is provided with a movable block and a connecting column. The movable block is provided with a second inclined face. The connecting column is provided with a spring. A spring installing hole and a supporting frame are arranged on the bottom cover. The sterile drug delivery system is novel in structure and reasonable in design. By means of a pressing system, side pressing for usage is achieved, and using habits of people are met. By means of a pump, it is ensured that liquid can be accurately dropped out quantitatively. By means of arrangement and cooperative use of the sprayer system and the piston connecting rod mechanism, external air can be thoroughly prevented from entering the bottle, and it becomes reality that a bacteriostatic agent is not added in the multi-dose eye drops.
Description
Technical field
The invention belongs to liquid container technical field, and in particular to a kind of multiple dose eye drops sterile administration system.
Background technology
Eye drops is meant by made by medicine and proper auxiliary materials for the sterile liquid formulations of instillation intraocular.As being directly used in
Eye plays the sterile preparation of therapeutic action, and its security, quality controllability are concerned always.Countries in the world are to drop
The quality requirement of eye agent is identical with the quality requirement of injection, and China also develops towards this direction at present.
At present, eye drops great majority are multiple-unit container on market, and for repeatedly continuously using, preparation holds behind Kaifeng
Easily by the microorganism pollution in tear and air during using and preserving, and then produce safety risks.In order to prevent drop
Eye agent microbial contamination, most of multiple dose eye drops in Reusability behind Kaifeng（Including antibioticses）All with the addition of suppression
Microbial inoculum, such as：Thimerosal, benzalkonium chloride, oxybenzene ethanol, anesin etc., for preventing use during microorganism it is secondary
Pollution.But bacteriostatic agent has cytotoxicity to ocular conjunctival epithelium cell, angle conjunctiva is damaged, cause tear film unstable, Jin Eryin
Ocular exception is played, is affected one's power of vision, abused the problem for causing by bacteriostatic agent in recent years and increasingly received publicity.Therefore multiple dose eye drip
Without bacteriostatic agent will be the trend of Future Development in agent formulation and technology.The existing eye drops without bacteriostatic agent mostly is single dose
Amount packaging, for single use, the packaging of this kind of structure, cost of manufacture is higher, and packaging material waste serious, and carry when outgoing
It is inconvenient.The drawbacks of for this kind of structural packaging, a kind of aseptic eye drop bottle of multiple dose is occurred in that on market, the eye drop bottle is
Realize that liquid is oozed by pressing bottle body bottom.But clinical discovery presses bottom, patient when in use, is inconvenient, is not inconsistent
Use habit is closed, often stab cornea because of operational error.
The content of the invention
For problems of the prior art, present invention aim at providing a kind of multiple dose eye drops easy to use
Sterile administration system.
The present invention is realized by the following technical programs：
Described multiple dose eye drops sterile administration system, including bottle and bottom, the bottle is arranged with bottom grafting,
The bottle includes outer blank, interior bottle, dust cover, the reservoir that is arranged in interior bottle（30）, the dust cover is arranged on outer blank bottle
At mouthful, interior bottle is arranged in outer blank, and on the interior bottle bottleneck boring cover mechanism is provided with, and outer blank bottle mouth position is provided with nozzle system,
The boring cover mechanism is connected with nozzle system by piston crank mechanism, it is characterised in that the delivery system also includes pressing machine
Structure, the pressing mechanism includes bottle cover, the arc opening being arranged on the wall of bottom side, the briquetting being arranged on arc opening,
Bottle cover socket is arranged on the outside of interior bottle, and bottle cover internal diameter matches with interior bottle external diameter, the internal diameter phase of bottle cover external diameter and bottom
It coincide, bottle cover bottom integral type is provided with pushing block, and the lower surface of the pushing block is provided with the first inclined plane, described to press
Briquetting is provided with movable block and connecting pole towards integral type on the direction of bottom inner space, and the upper surface of the movable block is arranged
There is the second inclined plane used cooperatively with the first inclined plane, socket on the connecting pole is provided with spring, bottom correspondence connecting pole
Position at be provided with spring mounting hole, the other end of the spring is fixedly connected with spring mounting hole, on bottom correspondence promote
Bracing frame is provided with the position of block, support frame as described above is used to support movable block.
Described multiple dose eye drops sterile administration system, it is characterised in that the pushing block is provided with two, and in flat
Row is arranged, and the movable block is provided with two, and connecting pole is arranged between two movable blocks, and support frame as described above is provided with four.
Described multiple dose eye drops sterile administration system, it is characterised in that the boring cover mechanism includes boring cover and boring cover
The pump housing that integral type is arranged；The nozzle system includes shower nozzle, water sealing plug, and the shower nozzle includes bullet and cylindrical body, described
Cylindrical body is extend into inside outer blank, and the bottom of cylindrical body is connected with boring cover, and the bullet socket is arranged on water sealing plug
On outer wall；The piston crank mechanism includes disjunctor piston, upper piston, and the disjunctor piston is through the pump housing and bullet, disjunctor
The lower end of piston is provided with ball valve, extend on the disjunctor piston of pump body socket and is provided with lower spring, disjunctor piston it is upper
A liquid containing chamber is left between end and upper piston, socket on the upper piston is provided with spring.
Described multiple dose eye drops sterile administration system, it is characterised in that the side of the water sealing plug is provided with out liquid
Hole, between the water sealing plug outer wall and shower nozzle inwall of correspondence fluid hole side the runner for flowing out for liquid is left.
Described multiple dose eye drops sterile administration system, it is characterised in that the position of the fluid hole is higher than liquid containing
The position in chamber.
Described multiple dose eye drops sterile administration system a, it is characterised in that circle is provided with the inwall of the water sealing plug
Groove, is provided with the annular projection used with groove fit at the position of respective slot on disjunctor piston.
Described multiple dose eye drops sterile administration system, it is characterised in that the shoulder of the interior bottle is provided with passage.
Present configuration is novel, reasonable in design, by the pressing system for being arranged on bottom side wall and inner space, realizes side
Portion's pressing is used, and meets the use habit of people, greatly facilitates user；Meanwhile, the setting of the pump housing, it is ensured that liquid can
Accurate quantification is oozed, and the setting of nozzle system and piston crank mechanism and is used cooperatively, it is also ensured that every time during pressing body, energy
Extraneous air is thoroughly prevented to enter in bottle so that multiple dose becomes a reality without bacteriostatic agent.
Description of the drawings
Fig. 1 is external structure schematic diagram of the present invention；
Fig. 2 is cross section structure diagram of the present invention；
Fig. 3 is bottom overall structure diagram；
Fig. 4 is bottom cross section structure diagram；
Fig. 5 is bottle cover structural representation；
Fig. 6 is bottle cover cross section structure diagram；
Fig. 7 is the fast structural representation of pressing；
Fig. 8 is nozzle structure schematic diagram；
Fig. 9 is pump body structure schematic diagram；
In figure, 1- bottoms, 2- outer blanks, bottle in 3-, 4- dust covers, 5- bottle covers, 6- arc openings, 7- briquettings, 8- is promoted
Block, the inclined planes of 9- first, 10- movable blocks, 11- connecting poles, the inclined planes of 12- second, 13- springs, 14- spring mounting holes, 15-
Support, 16- boring covers, the 17- pump housings, 18- shower nozzles, 19- water sealing plugs, 20- bullets, 21- cylindrical bodies, 22- disjunctor pistons, on 23-
Piston, 24- ball valves, 25- lower springs, 26- liquid containings chamber, the upper springs of 27-, 28- fluid holes, 29- runners, 30- reservoirs,
31- passages.
Specific embodiment
The present invention is described in further detail below in conjunction with Figure of description, and provides specific embodiment.
As described in Fig. 1-9, a kind of multiple dose eye drops sterile administration system of the invention is mainly used in containing without antibacterial
The eye-drops preparations of agent so that multiple dose eye drops becomes a reality without bacteriostatic agent.Including bottle and bottom 1, bottle and bottom 1
Grafting is arranged, and bottle includes outer blank 2, interior bottle 3, dust cover 4, the reservoir 30 that is arranged in interior bottle, and dust cover 4 is arranged on outer blank
2 bottle mouth positions, interior bottle 3 is arranged in outer blank 2, and boring cover mechanism is provided with the bottleneck of interior bottle 3, and outer blank bottle mouth position is provided with shower nozzle system
System, boring cover mechanism is connected with nozzle system by piston crank mechanism, the intracapsular splendid attire eye-drops preparations of liquid storage, to guarantee eye-drops preparations
Ooze, the delivery system also includes pressing mechanism, and pressing mechanism includes bottle cover 5, the arc opening that is arranged on the side wall of bottom 1
6th, the briquetting 7 being arranged on arc opening, bottle cover socket is arranged on the outside of interior bottle, bottle cover internal diameter and interior bottle external diameter kissing
Close, bottle cover external diameter matches with the internal diameter of bottom, bottle cover bottom integral type is provided with pushing block 8, the lower surface of pushing block is arranged
There is the first inclined plane 9, briquetting 7 is provided with movable block 10 and connecting pole 11 towards integral type on the direction of the inner space of bottom 1,
The upper surface of movable block 10 is provided with the second inclined plane 12 used cooperatively with the first inclined plane 9, the inclination of the first inclined plane
Direction is that pushing block is little apart from bottom distance from bottom near one end of spring mounting hole, and pushing block is near one end of arc opening
Big apart from bottom distance from bottom, the incline direction of the second inclined plane is just contrary with the incline direction of the first inclined plane；Connecting pole
Upper socket is provided with spring 13, and at the position of bottom correspondence connecting pole spring mounting hole 14, the other end and bullet of spring are provided with
Spring installing hole is fixedly connected, and is provided with bracing frame 15 on bottom 1 at the position of correspondence pushing block, and bracing frame is used to support movement
Block.During to realize briquetting pressing, it is ensured that what is coordinated between movable block and pushing block is smooth and stable, and pushing block generally sets
Two are equipped with, and are set in parallel, equally, movable block correspondence pushing block is also equipped with two, meanwhile, connecting pole is arranged on two shiftings
Between motion block, bracing frame is provided with four, and four bracing frames are in length and breadth two rows setting, and bracing frame is used to support movable block.
Boring cover mechanism includes the pump housing 17 that boring cover 16 and boring cover integral type are arranged, and the pump housing adopts the quantitative pump housing, to realize
Liquid is quantitatively oozed；Nozzle system includes shower nozzle 18, water sealing plug 19, and shower nozzle includes bullet 20 and cylindrical body 21, cylindrical body
21 extend into inside outer blank 2, and the bottom of cylindrical body 21 is connected with boring cover, and bullet socket is arranged on the outer wall of water sealing plug 19
On；Piston crank mechanism includes disjunctor piston 22, upper piston 23, and disjunctor piston 22 is lived through the pump housing 17 and bullet 20, disjunctor
The lower end of plug is provided with ball valve 24, extend on the disjunctor piston of pump body socket and is provided with lower spring 25, disjunctor piston with
The concrete annexation of water sealing plug is that a circle groove is provided with the inwall of water sealing plug, the position of respective slot on disjunctor piston
The place of putting is provided with the annular projection used with groove fit；A liquid containing chamber is left between the upper end of disjunctor piston and upper piston
26, socket on upper piston is provided with spring 27.To realize oozing for eye-drops preparations, the side of water sealing plug is provided with fluid hole
28, leave the runner 29 for flowing out for liquid, and fluid hole between the water sealing plug outer wall and shower nozzle inwall of correspondence fluid hole 28 side
Position higher than liquid containing chamber position.Reservoir is made using soft material, and the shoulder of interior bottle 3 is provided with passage
31, to guarantee that liquid balances the air pressure inside and outside interior bottle after flowing out by changing the shape of reservoir.
The present invention was used and was referred to as, and when using, was first turned on dust cover 4, and hand-held bottle is directed at eye, by briquetting 7, presses
Briquetting 7 to the inner space of bottom 1 is moved, and spring 13 is compressed, and drives movable block 10 along bracing frame 15 towards spring mounting hole 14
Direction movement, in the moving process of movable block 10, promote pushing block 8 to move up, drive bottle cover 5 and interior bottle 3 along disjunctor piston
Move on 22, ball valve 24 seals the lower end of the pump housing 17, and lower spring 25 is compressed, pressure increase in the pump housing 17, the liquid in the pump housing is along even
The through hole of body piston centre is entered in liquid containing chamber 26, meanwhile, liquid containing cavity pressure increase, when liquid influx reaches
During 0.05ml, upper piston 23 is washed open, upper spring 27 is compressed, and liquid flows out from fluid hole 28, between Jing water sealing plugs and shower nozzle
Runner 29 is oozed, and pressure drop in liquid containing chamber 26, upper spring 27 resets, and promotes upper piston 23 to move down, and blocks fluid hole 28,
Briquetting 7 is unclamped, in the presence of the screen resilience of spring 13, the opposite direction of movable block 10 movement, pushing block 8 drives bottle cover 5, interior bottle 3
And the pump housing 17 declines, lower spring 25 resets, and ball valve 24 is separated with the pump housing 17, and liquid is flowed to inside the pump housing 17, completes an action.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, on the premise of without departing from the technology of the present invention principle, some improvement and deformation can also be made, these improve and deform
Also should be regarded as protection scope of the present invention.
Claims (7)
1. multiple dose eye drops sterile administration system, including bottle and bottom（1）, the bottle is arranged with bottom grafting, described
Bottle includes outer blank（2）, interior bottle（3）, dust cover（4）, the reservoir that is arranged in interior bottle（30）, the dust cover（4）Arrange
In outer blank（2）Bottle mouth position, interior bottle（3）It is arranged on outer blank（2）It is interior, the interior bottle（3）Boring cover mechanism, outer blank bottle are provided with bottleneck
Nozzle system is provided with mouthful, the boring cover mechanism is connected with nozzle system by piston crank mechanism, it is characterised in that this is given
Medicine system also includes pressing mechanism, and the pressing mechanism includes bottle cover（5）, be arranged on bottom（1）Arc opening on the wall of side
（6）, be arranged on arc opening（6）On briquetting（7）, the bottle cover（5）Socket is arranged on interior bottle（3）Outside, bottle cover（5）
Internal diameter and interior bottle（3）External diameter matches, bottle cover（5）External diameter and bottom（1）Internal diameter match, the bottle cover（5）Bottom one
Formula is provided with pushing block（8）, the pushing block（8）Lower surface be provided with the first inclined plane（9）, the briquetting（7）Direction
Bottom（1）Integral type is provided with movable block on the direction of inner space（10）And connecting pole（11）, the movable block（10）It is upper
End face is provided with and the first inclined plane（9）The second inclined plane for using cooperatively（12）, the connecting pole（11）Upper socket is provided with
Spring（13）, bottom（1）Correspondence connecting pole（11）Position at be provided with spring mounting hole（14）, the spring（13）It is another
End and spring mounting hole（14）It is fixedly connected, bottom（1）Upper correspondence pushing block（8）Position at be provided with bracing frame（15）, institute
State bracing frame（15）For supporting movable block（10）.
2. multiple dose eye drops sterile administration system according to claim 1, it is characterised in that the pushing block（8）Arrange
There are two, and be set in parallel, the movable block（10）Two are provided with, connecting pole（11）It is arranged between two movable blocks, institute
State bracing frame（15）It is provided with four.
3. multiple dose eye drops sterile administration system according to claim 1, it is characterised in that the boring cover mechanism includes
Boring cover（16）The pump housing arranged with boring cover integral type（17）；The nozzle system includes shower nozzle（18）, water sealing plug（19）, it is described
Shower nozzle includes bullet（20）And cylindrical body（21）, the cylindrical body（21）It extend into outer blank（2）Inside, and cylindrical body（21）'s
Bottom and boring cover（16）It is connected, the bullet（20）Socket is arranged on water sealing plug（19）On outer wall；The piston rod
Mechanism includes disjunctor piston（22）, upper piston（23）, the disjunctor piston（22）Through the pump housing（17）And bullet（20）, disjunctor
Piston（22）Lower end be provided with ball valve（24）, it extend into the disjunctor piston of pump body（22）Upper socket is provided with lower spring
（25）, disjunctor piston（22）Upper end and upper piston（23）Between leave a liquid containing chamber（26）, the upper piston（23）On
Socket is provided with spring（27）.
4. multiple dose eye drops sterile administration system according to claim 3, it is characterised in that the water sealing plug（19）'s
Side is provided with fluid hole（28）, correspondence fluid hole（28）Leave between the water sealing plug outer wall and shower nozzle inwall of side and flow for liquid
The runner for going out（29）.
5. multiple dose eye drops sterile administration system according to claim 4, it is characterised in that the fluid hole（28）'s
Position is higher than liquid containing chamber（26）Position.
6. multiple dose eye drops sterile administration system according to claim 3, it is characterised in that the water sealing plug（19）'s
A circle groove, disjunctor piston are provided with inwall（22）The ring-type used with groove fit is provided with the position of upper respective slot
It is raised.
7. multiple dose eye drops sterile administration system according to claim 1, it is characterised in that the interior bottle（3）Shoulder
It is provided with passage（31）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510592089.XA CN105173421B (en) | 2015-09-17 | 2015-09-17 | Sterile drug delivery system for multi-dose eye drops |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510592089.XA CN105173421B (en) | 2015-09-17 | 2015-09-17 | Sterile drug delivery system for multi-dose eye drops |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105173421A CN105173421A (en) | 2015-12-23 |
| CN105173421B true CN105173421B (en) | 2017-05-10 |
Family
ID=54895996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510592089.XA Active CN105173421B (en) | 2015-09-17 | 2015-09-17 | Sterile drug delivery system for multi-dose eye drops |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105173421B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997507B (en) * | 2016-06-25 | 2018-11-23 | 利辛县眼病防治所 | A kind of eyedrops bottle |
| CN106890092B (en) * | 2017-04-21 | 2023-10-10 | 李金全 | Medicine bottle convenient for administration of vagina and anus |
| CN109223287B (en) * | 2018-08-26 | 2020-11-24 | 重庆市奉节中心血站 | Arm fixing device for arm fracture patient |
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|---|---|---|---|---|
| CN2253730Y (en) * | 1995-12-07 | 1997-05-07 | 马爱和 | Inner pressing paste bag |
| JP2001097467A (en) * | 1999-09-30 | 2001-04-10 | Yoshino Kogyosho Co Ltd | Pump type liquid pouring container |
| CN1650773A (en) * | 2004-02-02 | 2005-08-10 | 寿印刷纸工株式会社 | Side knock type feeding mechanism |
| CN201580689U (en) * | 2009-07-13 | 2010-09-15 | 谢新国 | Vacuum organ type bottle |
| CN102438914A (en) * | 2009-05-22 | 2012-05-02 | 大塚制药株式会社 | Container for eye drops |
| KR20130097397A (en) * | 2012-02-24 | 2013-09-03 | 정규선 | Jet type dispenser that using air pressure |
| CN204979781U (en) * | 2015-09-17 | 2016-01-20 | 陈超 | Aseptic delivery system of many dosage eye drop |
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2015
- 2015-09-17 CN CN201510592089.XA patent/CN105173421B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2253730Y (en) * | 1995-12-07 | 1997-05-07 | 马爱和 | Inner pressing paste bag |
| JP2001097467A (en) * | 1999-09-30 | 2001-04-10 | Yoshino Kogyosho Co Ltd | Pump type liquid pouring container |
| CN1650773A (en) * | 2004-02-02 | 2005-08-10 | 寿印刷纸工株式会社 | Side knock type feeding mechanism |
| CN102438914A (en) * | 2009-05-22 | 2012-05-02 | 大塚制药株式会社 | Container for eye drops |
| CN201580689U (en) * | 2009-07-13 | 2010-09-15 | 谢新国 | Vacuum organ type bottle |
| KR20130097397A (en) * | 2012-02-24 | 2013-09-03 | 정규선 | Jet type dispenser that using air pressure |
| CN204979781U (en) * | 2015-09-17 | 2016-01-20 | 陈超 | Aseptic delivery system of many dosage eye drop |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105173421A (en) | 2015-12-23 |
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