CN105111320B - Medicinal soluble starch preparation method - Google Patents
Medicinal soluble starch preparation method Download PDFInfo
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- CN105111320B CN105111320B CN201510592520.0A CN201510592520A CN105111320B CN 105111320 B CN105111320 B CN 105111320B CN 201510592520 A CN201510592520 A CN 201510592520A CN 105111320 B CN105111320 B CN 105111320B
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Abstract
The invention relates to a medicinal soluble starch preparation method. Soluble starch is prepared through an enzyme acid hydrolysis method. The soluble starch is prepared from, by mass, 500 kg of starch, 50 g of a-amylase, 5 g of CaCl2, 0.295-1.18 kg of hydrochloric acid and 50 kg of water. According to the technical process of the soluble starch, an a-amylase aqueous solution and a CaCl2 solution are evenly sprayed into the starch with the water content being 1%-6%, a reaction is carried out for 30 min after the temperature is raised to 70 DEG C, a reaction is carried out for 1-6 h after a hydrochloric acid solution is sprayed into the starch and the temperature is raised to 100-110 DEG C, vacuumizing is carried out for 0.5 h, PH is adjusted to 6.0-7.5 through a NaHCO3 solution, and a finished product is obtained through screening. The method has the advantages that the product is stable, clarity is good, reduction matter content is low, and standards of the pharmacopeia of the 2015 edition are met; by means of acid enzyme collocation, reaction efficiency is improved, and properties of the product are not affected by inactivation of enzymes in an acidification reaction.
Description
Technical field
The present invention relates to a kind of preparation method of medicinal soluble starch.
Background technology
Soluble starch is white or off-white powder, is starch by the processing of the method such as enzyme or sour water solution, improve its
Solubility is obtained in water, is one kind of denaturated starch by acid.It does not dissolve in cold water, alcohol and ether, is dissolved in hot water.Product is right in neutrality
Ph stability, adsorptivity is strong, good fluidity, medicinal at present as diluent and disintegrant, using wide in solid pharmaceutical preparation production
It is general.The domestic production producer is less, and quality control index is not fine enough, and clarity is larger with reducing substances differences between batches.
The content of the invention
Object of the present invention is to provide a kind of medicinal soluble starch preparation method, for food grade soluble starch
Clarity is poor when in use, reducing substances is high defect and existing preparation method is improved, it is desirable to provide one kind clarification
Spend, the good medicinal soluble starch of reducing substances.
The present invention is achieved like this, and method and step is：
1）Enzyme digestion reaction：Weigh in the starch input reactor of ormal weight, a- amylase water is uniformly sprayed into toward reactor
Solution（Concentration is 1%, 50g a- amylase, 5kg water）、CaCl2Solution（Concentration is 0.1%, 5gCaCl2,5kg water）Temperature rises to
Reacted 30 minutes at 70 DEG C.
2）Acidification reaction：After enzyme digestion reaction terminates, hydrochloric acid solution is uniformly sprayed into（Hydrochloric acid content 0.295-1.18kg, water
Reacted 1-6 hours after being warming up to 100-110 DEG C after 40kg).After periodically sampling detects that its 1% aqueous solution boils in acidification reaction
Whether it is in clear shape.
4）Neutralization reaction：After acidification reaction terminates, sampling detection pH value, if PH is between 6.0-7.5, can blanking carry out
Next step cooling reaction；If PH is less than 6.0, need to spray into NaHCO3
After solution regulation PH to 6.0-7.5, blanking carries out next step cooling reaction.
5）Cooling reaction：After neutralization terminates, material blanking enters in cooling tank, is cooled to less than 65 DEG C, and cooling terminates.
6）Packaging：Material crosses 80 mesh vibratory sieve sub-sieves after cooling, into packaging process.
The solution have the advantages that：
1）Product stabilization, clarity is good, and reducing substances is low, meets 2015 editions standards of pharmacopoeia；The heating of its 1% aqueous solution is boiled
It is in clear shape after boiling, is not become cloudy after cooling, product property stabilization.
2）It is used in conjunction using sour enzyme, reaction efficiency is improved, intensification can inactivate enzyme in acidification reaction does not influence product property.
Specific embodiment
Embodiment one
1）Enzyme digestion reaction：Weigh in the starch input reactor of ormal weight, a- amylase water is uniformly sprayed into toward reactor
Solution（Concentration is 1%, 50g a- amylase, 5kg water）、CaCl2Solution（Concentration is 0.1%, 5gCaCl2,5kg water）Temperature rises to
Reacted 30 minutes at 70 DEG C.
2）Acidification reaction：After enzyme digestion reaction terminates, hydrochloric acid solution is uniformly sprayed into（Hydrochloric acid content 1.18kg, water 40kg) rise afterwards
Reacted 1 hour after warm to 110 DEG C.Whether periodically sampling detects its 1% aqueous solution after boiling in clear in acidification reaction
Shape.
3）Neutralization reaction：After acidification reaction terminates, sampling detection pH value, if PH is between 6.0-7.5, can blanking carry out
Next step cooling reaction；If PH is less than 6.0, need to spray into NaHCO3
After solution regulation PH to 6.0-7.5, blanking carries out next step cooling reaction.
4）Cooling reaction：After neutralization terminates, material blanking enters in cooling tank, is cooled to less than 65 DEG C, and cooling terminates.
5）Packaging：Material crosses 80 mesh vibratory sieve sub-sieves after cooling, into packaging process.
Embodiment two：
1）Enzyme digestion reaction：Weigh in the starch input reactor of ormal weight, a- amylase water is uniformly sprayed into toward reactor
Solution（Concentration is 1%, 50g a- amylase, 5kg water）、CaCl2Solution（Concentration is 0.1%, 5gCaCl2,5kg water）Temperature rises to
Reacted 30 minutes at 70 DEG C.
2）Acidification reaction：After enzyme digestion reaction terminates, hydrochloric acid solution is uniformly sprayed into（Hydrochloric acid content 0.708kg, water 40kg) after
Reacted 3 hours after being warming up to 110 DEG C, vacuumized 0.5 hour.After periodically sampling detects that its 1% aqueous solution boils in acidification reaction
Whether it is in clear shape.
3）Neutralization reaction：After acidification reaction terminates, sampling detection pH value, if PH is between 6.0-7.5, can blanking carry out
Next step cooling reaction；If PH is less than 6.0, need to spray into NaHCO3
After solution regulation PH to 6.0-7.5, blanking carries out next step cooling reaction.
4）Cooling reaction：After neutralization terminates, material blanking enters in cooling tank, is cooled to less than 65 DEG C, and cooling terminates.
5）Packaging：Material crosses 80 mesh vibratory sieve sub-sieves after cooling, into packaging process.
Embodiment three
1）Enzyme digestion reaction：Weigh in the starch input reactor of ormal weight, a- amylase water is uniformly sprayed into toward reactor
Solution（Concentration is 1%, 50g a- amylase, 5kg water）、CaCl2Solution（Concentration is 0.1%, 5gCaCl2,5kg water）Temperature rises to
Reacted 30 minutes at 70 DEG C.
2）Acidification reaction：After enzyme digestion reaction terminates, hydrochloric acid solution is uniformly sprayed into（Hydrochloric acid content 0.295kg, water 40kg) after
Reacted 6 hours after being warming up to 110 DEG C.Whether periodically sampling detects its 1% aqueous solution after boiling in clear in acidification reaction
Shape.
3）Neutralization reaction：After acidification reaction terminates, sampling detection pH value, if PH is between 6.0-7.5, can blanking carry out
Next step cooling reaction；If PH is less than 6.0, need to spray into NaHCO3
After solution regulation PH to 6.0-7.5, blanking carries out next step cooling reaction.
4）Cooling reaction：After neutralization terminates, material blanking enters in cooling tank, is cooled to less than 65 DEG C, and cooling terminates.
5）Packaging：Material crosses 80 mesh vibratory sieve sub-sieves after cooling, into packaging process.
Specific embodiment acid adding amount, reducing substances, clarity of solution detection data are as follows：
| Acid adding amount | Clarity of solution | Reducing substances | |
| Embodiment one | 1.18kg, water 40kg | No. 2 turbidity of ＜ | 216mg |
| Embodiment two | 0.708kg, water 40kg | No. 2 turbidity of ＜ | 121mg |
| Embodiment three | 0.295kg, water 40kg | No. 3 turbidity of ＜ | 98mg |
Embodiment shows to meet 2015 editions pharmacopeia using soluble starch clarity obtained in the technique and reducing substances
Standard, and it is stable in properties with the soluble starch that the method is produced, it is quality controllable.
Claims (4)
1. a kind of medicinal soluble starch preparation method, it is made up of following masses number raw material：Starch 500kg, a- amylase
50g、CaCl25g, hydrochloric acid 0.295-1.18kg, water 50kg, it is characterized in that method and step is：It is the starch of 1%-6% by water content,
It is 0.1%CaCl uniformly to spray into a- starch enzyme aqueous solution, concentration that concentration is 1%2Solution, 30 are reacted when temperature is risen into 70 DEG C
After minute, hydrochloric acid solution is sprayed into, hydrochloric acid solution is made up of 0.295-1.18kg hydrochloric acid and 40kg water, then is warming up to 100-110 DEG C
React 1-6 hours afterwards, vacuumize 0.5 hour, then use NaHCO3Solution adjusts PH to 6.0-7.5, and finished product sieving is obtained final product.
2. a kind of medicinal soluble starch preparation method according to claim 1, it is characterised in that：Described starch moisture
It is 1-6%.
3. a kind of medicinal soluble starch preparation method according to claim 1, it is characterised in that：Described starch is big
Rice starch, cornstarch or potato starch；Potato starch is farina or tapioca.
4. a kind of medicinal soluble starch preparation method according to claim 1, it is characterised in that：Described hydrochloric acid is work
Industry hydrochloric acid or reagent grade.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510592520.0A CN105111320B (en) | 2015-09-17 | 2015-09-17 | Medicinal soluble starch preparation method |
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| CN201510592520.0A CN105111320B (en) | 2015-09-17 | 2015-09-17 | Medicinal soluble starch preparation method |
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| CN105111320B true CN105111320B (en) | 2017-05-24 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1161045A (en) * | 1994-09-29 | 1997-10-01 | 弗雷泽纽斯股份公司 | Method for producing starch degradation products |
| CN102050880A (en) * | 2009-10-29 | 2011-05-11 | 黄雅典 | Method for preparing soluble starch |
| CN102675476A (en) * | 2012-05-20 | 2012-09-19 | 湖州展望药业有限公司 | Production method for soluble starch |
-
2015
- 2015-09-17 CN CN201510592520.0A patent/CN105111320B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1161045A (en) * | 1994-09-29 | 1997-10-01 | 弗雷泽纽斯股份公司 | Method for producing starch degradation products |
| CN102050880A (en) * | 2009-10-29 | 2011-05-11 | 黄雅典 | Method for preparing soluble starch |
| CN102675476A (en) * | 2012-05-20 | 2012-09-19 | 湖州展望药业有限公司 | Production method for soluble starch |
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| CN105111320A (en) | 2015-12-02 |
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