CN105106566B - A kind of emulsifiable paste and preparation method thereof that anti-inflammation and sterilization is antipruritic - Google Patents

Abstract

The invention discloses an anti-inflammatory, sterilizing and antipruritic cream and a preparation method thereof. The cream contains the following substances: aloe oil, perilla seed oil, evening primrose oil, calendula oil, distilled water, APG type Emulsifier SMONTANOV L, wheat-derived emulsifier MONTANOV82, peppermint extract, wild chrysanthemum extract, Sophora flavescens extract, white fresh bark extract, Kochia chinensis extract, saponins thorn extract, cnidium fruit extract, ice crystal formation agent, carbomer 941, glycerin, 0.2% ethylparaben 75% ethanol solution. Compared with the prior art, the present invention uses a variety of traditional Chinese medicine extracts. Under the synergistic effect of these traditional Chinese medicines, the efficacy of anti-inflammatory, sterilizing and antipruritic is more obvious. Compared with the previous single medicine, it can be faster and more effective. to heal the affected area. Moreover, these kinds of traditional Chinese medicines have less toxic and side effects and are safe to use, which further highlights the advantages of this product.

Description

Anti-inflammatory, sterilizing and antipruritic cream and preparation method thereof

technical field

The invention belongs to the field of medicine, and in particular relates to an anti-inflammatory, sterilizing and antipruritic cream and a preparation method thereof.

Background technique

In today's society, the destruction of the ecological environment and global warming have caused the proliferation of various mosquitoes. In daily life, people will inevitably be bitten by some mosquitoes, especially in the summer when mosquitoes are rampant, redness, swelling, swelling, and itching are all normal things. Some people even scratch their bodies with scars, yellow water, and inflammation because of the extreme itching. Especially infants and children, the skin is very delicate, and the situation is even more serious after being bitten by mosquitoes.

We often think that these are just superficial injuries and innocuous. In fact, it is a big mistake. Mosquito bites must not be underestimated, ranging from allergies to life-threatening, which has brought a huge impact on people's physical and mental health.

The harm of mosquitoes to people is not only redness, swelling, itching and sleep disturbance after being bitten, but also the most dangerous thing is that they can spread diseases. Mosquitoes become long-term storage hosts for pathogens after they bite humans or livestock with pathogens, and can transmit pathogens to healthy people when they bite people again. Mosquitoes spread disease to more than one-tenth of the world's population each year, and about 2 million people die from diseases transmitted to them by female mosquitoes. Diseases transmitted by mosquitoes mainly include Japanese encephalitis, malaria, dengue fever and dengue hemorrhagic fever, filariasis, and yellow fever.

In addition to these conditions, eczema, itchy skin and other conditions are also common. Eczema is a skin inflammatory reaction with severe itching caused by various internal and external factors. Divided into acute, subacute and chronic stages. In the acute phase, it tends to exudate, while in the chronic phase, it is infiltrating and hypertrophic. Some patients directly show as chronic eczema. The skin lesions are characterized by pleomorphism, symmetry, itching, and recurrent attacks. Pruritus is a dermatological symptom with only itching of the skin without primary skin lesions. According to the scope and location of pruritus, it is generally divided into two categories: systemic and localized.

Therefore, it is particularly important to treat wounds or relieve itching. Most of the ointments about mosquito bites, anti-inflammatory type ointments, and antipruritic ointments currently on the market are chemical products, containing various additives harmful to the skin, and generally contain Side effects, irritating effects, and not suitable for infants and young children. Though also some ointments mostly are the combination product of Chinese medicine and chemical medicine, have these defectives equally. However, the above ointments are indispensable medicines for home travel, and everyone has to use them.

Therefore, we are in urgent need of a fast and effective drug to relieve swelling and itching, and damaged skin should also be cared for and repaired in time. Natural and healthy ointment is the main trend of research and development at home and abroad in the future.

Contents of the invention

In order to solve the above technical problems, the present invention provides an anti-inflammatory, sterilizing and antipruritic cream, which contains a variety of traditional Chinese medicine extracts, and the synergistic effect of several traditional Chinese medicines has more obvious anti-inflammatory, sterilizing and antipruritic efficacy.

The invention also provides a preparation method of the anti-inflammatory, sterilizing and antipruritic cream, and the prepared cream has good effect of anti-inflammatory, sterilizing and antipruritic.

A kind of emulsifiable paste for anti-inflammatory, sterilizing and antipruritic provided by the present invention comprises the following raw materials:

Described peppermint extract is prepared by the following method:

Weigh an appropriate amount of mint, soak in water for 0.15-0.8h, heat and decoct at 90-100°C to extract 3 times, add 8-18 times the amount of water for the first time, extract for 0.5-2h, add 8-15 times the amount for the second time Water, extract for 0.5-1.5h, add 5-12 times the amount of water for the third time, extract for 0.5-1.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 3-6 times the weight of mint g/ml, filter Instantly.

Described Fructus Cnidii extract is prepared by the following method:

Weigh an appropriate amount of Fructus Cnidii, soak in 60%-85% ethanol for 0.15-0.8h, reflux extract with 60%-85% ethanol for 3 times, add 8-18 times the amount of solvent for the first time, extract for 0.5-2h, and extract for 0.5-2h for the second time Add 8-15 times the amount of solvent, extract 0.5-1.5h, add 5-12 times the amount of solvent for the third time, extract 0.5-1.5h, filter each time, combine the filtrate, and concentrate the volume of the filtrate to 3-3% of the weight of Fructus Cnidii 6 times g/ml, obtained by filtration.

Described wild chrysanthemum extract is prepared by the following method:

Weigh an appropriate amount of wild chrysanthemum, soak it in 40%-90% alcohol for 0.15-0.8h, reflux extract it with 40%-90% ethanol three times, use 8-18 times the amount of solvent for the first time, extract it for 0.5-2.5h, filter, For the second time, use 8-15 times the amount of solvent, extract for 0.5-2.5h, and for the third time use 5-12 times the amount of solvent, extract for 0.5-1.5h, filter respectively, combine the filtrates, and concentrate under reduced pressure to 6-10% of the weight of wild chrysanthemum. 10 times g/ml, obtained by filtration.

Described sophora flavescens extract is prepared by the following method:

Take an appropriate amount of Sophora flavescens, crush it into a coarse powder, soak it in 50%-80% ethanol for 0.15-0.8h, reflux and extract 3 times, use 8-18 times the amount of solvent for the first time, extract for 0.5-2.5h, filter, and the second time Use 8-15 times the amount of solvent, extract for 0.5-2.5h, and use 5-12 times the amount of solvent for the third time, extract for 0.5-1.5h, filter separately, combine the filtrates, and concentrate under reduced pressure to 6-10 times the weight of Sophora flavescens /ml, obtained by filtration.

Described fresh bark extract is prepared by the following method:

Take an appropriate amount of white fresh skin, crush it into a coarse powder, soak it in 75%-95% ethanol for 0.15-0.8h, reflux and extract 3 times, use 8-18 times the amount of solvent for the first time, extract for 0.5-2.5h, filter, and secondly Use 8-15 times the amount of solvent for the first time, extract for 0.5-2.5 hours, use 5-12 times the amount of solvent for the third time, extract for 0.5-1.5 hours, filter respectively, combine the filtrates, and concentrate under reduced pressure to 6-10 times the weight of white fresh skin. Times g/ml, filter that is.

Described saponin root extract is prepared by the following method:

Take an appropriate amount of saponins, crush it into a coarse powder, soak it in 60%-80% ethanol for 0.15-0.8h, reflux and extract 3 times, use 8-18 times the amount of solvent for the first time, extract for 0.5-2.5h, filter, the second time Use 8-15 times the amount of solvent for the first time, extract for 0.5-2.5 hours, use 5-12 times the amount of solvent for the third time, extract for 0.5-1.5 hours, filter respectively, combine the filtrates, and concentrate under reduced pressure to 6-10 times the weight of the saponins. Times g/ml, filter that is.

Described Kochia scoparia extract is prepared by the following method:

Take an appropriate amount of Kochia chinensis, soak in 70%-90% ethanol for 0.15-0.8h, reflux extraction 3 times, use 8-18 times the amount of solvent for the first time, extract 0.5-2.5h, filter, and use 8-15 times for the second time Double the amount of solvent, extract for 0.5-2.5h, use 5-12 times the amount of solvent for the third time, extract for 0.5-1.5h, filter respectively, combine the filtrates, concentrate under reduced pressure to 6-10 times the weight of Kochia scoparia, g/ml, Filter and serve.

A kind of preparation method of anti-inflammatory, sterilizing and antipruritic emulsifiable cream provided by the present invention, comprises the following steps:

a) Weigh carbomer 9410.2-0.8g, add it into 50-100ml of distilled water, after mixing evenly, let it stand to fully swell, form gel a, and set aside;

b) Weigh 0.1-0.9g of the ice crystal forming agent, add it to 50-100ml of distilled water, after mixing evenly, let it stand still to fully swell, form gel b, and set aside;

c) Take aloe vera oil 1-5g, perilla seed oil 1-5g, evening primrose oil 1-5g, calendula oil 1-5g, APG type emulsifier SMONTANOV L 1-3g, wheat source emulsifier MONTANOV 821- 3g, heated on a water bath at 60-90°C, as the oil phase, for later use;

d) Take 7-12ml of distilled water, heat it on a 60-90°C water bath, and use it as the oil phase for later use;

e) When the temperature of the oil phase and the water phase are the same, add the oil phase into the water phase in a thin stream, and stir while adding until a uniform emulsion matrix 1 is formed;

d) Add gel a and gel b to emulsion base 1, mix well, add 0.5-1.5ml of peppermint extract, 0.5-1.5ml of wild chrysanthemum extract, 0.5-1.5ml of Sophora flavescens extract, white fresh bark 0.5-1.5ml of the extract, 0.5-1.5ml of Kochia chinensis extract, 0.5-1.5ml of Saponaria thorn extract, 0.5-1.5ml of Cnidium chinensis extract, stir and mix evenly, then add 0.2% ethylparaben 75 Add 0.5-1.5ml of % ethanol solution, add 1.5-4ml of glycerin, stir and mix evenly, and obtain the emulsifiable cream for anti-inflammatory, sterilizing and antipruritic.

Each composition among the present invention is as follows:

Peppermint has dispelling wind, heat dissipation, ward off dirty, detoxification function. Treat exogenous wind-heat, headache, conjunctival congestion, sore throat, food stagnation and flatulence, aphtha, toothache, sores and rashes.

Wild chrysanthemum has the functions of clearing heat and detoxifying, dispelling wind and calming liver. Mainly boils, carbuncles, erysipelas, eczema, dermatitis, wind-heat and cold, sore throat, hypertension. For furuncle carbuncle, conjunctival congestion and swelling pain, headache and dizziness.

Sophora flavescens clears away heat and dampness, dispels wind and kills parasites. Mainly damp-heat diarrhea, intestinal wind and blood in the stool, jaundice, dysuria, edema, leukorrhea, pruritus vulvae, scabies, leprosy, skin itching, wet toxin sores. Treatment of toxic heat and bloody dysentery, intestinal wind bleeding, jaundice, leucorrhea, infantile pneumonia, malnutrition, acute tonsillitis, hemorrhoids, rectal prolapse, skin itching, scabies and malignant sores, vaginal sores, wet itching, scrofula, and burns. External treatment of trichomonal vaginitis.

Radix Cortex Radix Clearing Heat and Damp Dampness, expelling wind and relieving itching, detoxification. Mainly rubella, eczema, scabies, jaundice, damp-heat arthralgia caused by wind-heat damp-toxin. For damp-heat sores, dripping yellow water, eczema, rubella, scabies sores, rheumatism-heat arthralgia, jaundice and red urine.

Fructus Kochia clears heat and promotes dampness, relieves itching due to wind. Mainly dysuria, stranguria, bloody dysentery, rubella, eczema, mange, skin itching, sores. It is used for astringent and painful urination, pruritus vaginal discharge, rubella, eczema, and itchy skin.

Glycyrrhiza japonica sterilizes and penetrates pus, searches for wind, and kills parasites. Mainly carbuncle and swollen toxin, scrofula, sore rash and persistent ringworm, wind-fever. It is used for the initial onset of carbuncle and gangrene or for the treatment of scabies and leprosy externally.

Fructus Cnidii warms the kidney and strengthens yang, dries dampness and kills parasites, dispels wind and relieves itching. Main scrotum damp itching, pruritus vulvae swelling and pain, rheumatic arthralgia, eczema scabies. For cold-damp leukorrhagia, arthralgia due to dampness and low back pain; external treatment of vulvar eczema, pruritus vulvae, trichomonas vaginitis.

Aloe vera oil contains natural gelatinous substances, water-retaining lignin, and has strong penetrating substances, which can help nutrients penetrate into the skin. It has direct beauty effects such as moisturizing, whitening and freckle removal, anti-aging, and anti-allergic. At the same time, it can inhibit the pathogenic microorganisms and bacteria on the skin surface, kill the mites harmful to human skin, prevent the reproduction of microorganisms on the surface of the body, and prevent the occurrence of skin diseases. Suitable for oily skin, balances, inhibits sebum secretion, and promotes wound healing.

Perilla seed oil is rich in α-linolenic acid and its derivatives, which can be used to formulate various cosmetics, which can prevent dry, rough, chapped skin and prevent skin aging. At the same time, it is also the savior of allergic skin, because the allergic skin is very fragile, you should try not to use chemical skin care products, but perilla seed oil can soothe the hot and itchy skin, and play a certain role in moisturizing.

Evening primrose oil has a soft and elastic feeling on the skin. It has good tactility and ductility, and is easily absorbed by skin microvessels. It can promote blood circulation, prevent epidermal keratinization, keep the skin lubricated, and delay skin aging. It is very good Emollients and humectants enhance the water retention capacity of the skin, give it a moisturizing feeling, promote the stretching of the skin, and prevent excessive greasy feeling after use. Evening primrose oil has a good auxiliary medical effect on seborrheic dermatitis and trauma.

Calendula oil is rich in vitamin A, which can prevent pigmentation, improve skin luster and elasticity, slow down aging, and prevent skin from sagging and wrinkling. Animal studies suggest that calendula may help protect against sun-induced skin damage and may also help protect against sun-induced skin damage.

This product mainly contains the extracts of mint, wild chrysanthemum, flavescens, white fresh skin, Kochia scoparia, saponins, and cnidium, which greatly improves the effect of anti-inflammatory, sterilizing and antipruritic. There is a certain synergistic effect, and most of them are healthy and harmless vegetable oils. The combination with traditional Chinese medicine is healthier, more efficient, and has no side effects. It is really ready-to-use, suitable for urgent needs, convenient to store, portable, saves the decoction process, and eliminates the peculiar smell and bad stimulation when taking traditional Chinese medicine decoctions.

Compared with the prior art, the present invention adopts the extracts of peppermint, wild chrysanthemum, flavescens, white fresh skin, Kochia scoparia, saponins, and cnidium, and under the synergistic effect of these several traditional Chinese medicines, it can reduce inflammation and sterilize The antipruritic effect is more obvious. Compared with the previous single drug, it can heal the affected area more quickly and effectively. Moreover, these kinds of traditional Chinese medicines have less toxic and side effects and are safe to use, which further highlights the advantages of this product.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments.

Aloe oil used in the present invention, perilla seed oil, evening primrose oil, calendula oil are all commercially available.

Example 1

An anti-inflammatory, sterilizing and antipruritic cream, comprising the following raw materials:

A preparation method for anti-inflammatory, sterilizing and antipruritic emulsifiable cream, comprising the following steps:

1.1 Preparation of peppermint extract

Weigh 10g of mint, soak in water for 0.5h, heat and decoct at 95°C for 3 times, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, and add 5 times the amount of water for the third time Double the amount of water, extract for 1 hour, filter each time, combine the filtrates, concentrate the volume of the filtrates to 5 times the weight of mint (g/ml), and filter to obtain.

1.2 Preparation of Fructus Cnidii Extract

Weigh 10g of Fructus Cnidii, add 65% ethanol for 0.5h, heat and decoct at 95°C for 3 times, add 10 times the amount of 65% ethanol for the first time, extract for 1 hour, add 8 times the amount of 65% ethanol for the second time, extract 1h, add 5 times the amount of 65% ethanol for the third time, extract for 1h, filter each time, combine the filtrates, concentrate the volume of the filtrates to 5 times the weight of Fructus Cnidii (g/ml), and filter to obtain.

1.3 Preparation of wild chrysanthemum extract

Weigh 10g of wild chrysanthemum, soak in 70% ethanol for 0.15h, reflux and extract 3 times, use 10 times the amount of 70% ethanol for the first time, extract for 1h, filter, use 8 times the amount of 70% ethanol for the second time, extract for 1h, the second time Use 5 times the amount of 70% ethanol for three times, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of the wild chrysanthemum, and filter to obtain the product.

1.4 Preparation of Sophora flavescens extract

Weigh 10g of Sophora flavescens, crush it into a coarse powder, soak it in 65% ethanol for 0.12h, reflux and extract 3 times, use 10 times the amount of 65% ethanol for the first time, extract for 1 hour, filter, and use 8 times the amount of 65% ethanol for the second time , extracted for 1 hour, and used 5 times the amount of 65% ethanol for the third time, extracted for 1 hour, filtered separately, combined the filtrates, concentrated under reduced pressure to 6 times the weight of Sophora flavescens g/ml, and filtered to get the product.

1.5 Preparation of Cortex Cortex Extract

Weigh 10g of white fresh skin, crush it into coarse powder, soak it in 80% ethanol for 0.4h, reflux and extract 3 times, use 10 times the amount of 80% ethanol for the first time, extract for 1 hour, filter, and use 8 times the amount of 80% ethanol for the second time % ethanol, extract for 1 h, use 5 times the amount of 80% ethanol for the third time, extract for 1 h, filter respectively, combine the filtrates, concentrate under reduced pressure to 7 times g/ml of the weight of the white fresh skin, and filter to obtain.

1.6 Preparation of Kochia scoparia extract

Weigh 10g Kochia scoparia, soak in 80% ethanol for 0.3h, reflux and extract 3 times, first use 10 times the amount of solvent, extract for 1h, filter, use 8 times the amount of solvent for the second time, extract for 1h, and thirdly use 5 times the amount of solvent, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 9 times the weight of Kochia scoparia, and filter to obtain the product.

1.7 Preparation of saponins thorn extract

Weigh 10g of saponins, soak in 70% ethanol for 0.15h, reflux and extract 3 times, use 10 times the amount of solvent for the first time, extract for 1 hour, filter, use 8 times the amount of solvent for the second time, extract for 1 hour, and extract for the third time Use 5 times the amount of solvent, extract for 1 h, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of saponins g/ml, and filter to obtain the product.

1.8 Preparation of a kind of anti-inflammatory, sterilizing and antipruritic cream

a) Weigh 0.5g of carbomer, add it into 100ml of distilled water, after mixing evenly, let it stand to swell fully, form gel a, and set aside;

b) Weigh 0.5 g of the ice crystal forming agent, add it to 100 ml of distilled water, and after mixing evenly, let it stand still to allow it to fully swell, form gel b, and set aside;

c) Take 1g of aloe vera oil, 1g of perilla seed oil, 1g of evening primrose oil, 1g of calendula oil, 1g of APG emulsifier SMONTANOVL, and 821g of wheat-derived emulsifier MONTANOV, and heat it on a water bath at 80°C as the oil phase. spare;

d) Take 9ml of distilled water, heat it on a water bath at 80°C, and use it as the water phase for later use;

e) When the temperature of the oil phase and the water phase are the same, add the oil phase into the water phase in a thin stream, and stir while adding until a uniform emulsion matrix 1 is formed;

d) Add gel a and gel b to the emulsion base 1, mix well, add 0.5ml of peppermint extract, 0.5ml of wild chrysanthemum extract, 0.5ml of sophora flavescens extract, 0.5ml of white fresh bark extract, 0.5ml of Fuzi extract, 0.5ml of saponins extract, 0.5ml of Cnidium extract, stir and mix evenly, then add 1ml of 0.2% ethylparaben 75% ethanol solution, add 2ml of glycerin, stir and mix evenly, Anti-inflammatory and anti-itch cream.

Example 2

An anti-inflammatory, sterilizing and antipruritic cream, comprising the following raw materials:

A preparation method for anti-inflammatory, sterilizing and antipruritic emulsifiable cream, comprising the following steps:

2.1 Preparation of peppermint extract

Weigh 15g mint, soak in water for 0.5h, heat and decoct at 100°C for 3 times, add 12 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time, extract for 1 hour, and add 6 times the amount for the third time Double the amount of water, extract for 1 hour, filter each time, combine the filtrates, concentrate the volume of the filtrates to 6 times the weight of mint (g/ml), and filter to obtain.

2.2 Preparation of Fructus Cnidii Extract

Weigh 15g of Fructus Cnidii, soak in 75% ethanol for 0.5h, heat and decoct at 100°C for extraction three times, add 12 times the amount of 75% ethanol for the first time, extract for 1 hour, add 10 times the amount of 75% ethanol for the second time, Extract for 1h, add 6 times the amount of 75% ethanol for the third time, extract for 1h, filter each time, combine the filtrates, concentrate the volume of the filtrates to 6 times the weight of Fructus Cnidii (g/ml), and filter to obtain.

2.3 Preparation of wild chrysanthemum extract

Weigh 15g of wild chrysanthemum, soak in 75% ethanol for 0.5h, reflux extraction 3 times, first use 12 times the amount of 75% ethanol, extract for 1h, filter, and use 10 times the amount of 75% ethanol for the second time, extract for 1h, the second time Use 6 times the amount of 75% ethanol for three times, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of the wild chrysanthemum, and filter to obtain the product.

2.4 Preparation of Sophora flavescens extract

Weigh 15g of Sophora flavescens, crush it into coarse powder, soak it in 70% ethanol for 0.5h, reflux and extract 3 times, use 12 times the amount of solvent for the first time, extract for 1h, filter, and use 10 times the amount of solvent for the second time, extract for 1h, For the third time, use 6 times the amount of solvent, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of Sophora flavescens g/ml, and filter to obtain the product.

2.5 Preparation of Cortex Cortex Extract

Weigh 15g of white fresh skin, soak in 85% ethanol for 0.5h, reflux and extract 3 times, first use 12 times the amount of solvent, extract for 1 hour, filter, use 10 times the amount of solvent for the second time, extract for 1 hour, third time Use 6 times the amount of solvent, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of white fresh skin g/ml, and filter to obtain the product.

2.6 Preparation of Kochia chinensis extract

Weigh 15g Kochia scoparia, soak in 75% ethanol for 0.5h, reflux extraction 3 times, first use 12 times the amount of solvent, extract for 1h, filter, use 10 times the amount of solvent for the second time, extract for 1h, third time use 6 times the amount of solvent, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of Kochia scoparia, and filter to obtain.

2.7 Preparation of saponins thorn extract

Weigh 15g of saponins, crush into coarse powder, soak in 75% ethanol for 0.5h, reflux extraction 3 times, for the first time use 12 times the amount of 75% ethanol, extract for 1h, filter, and for the second time use 10 times the amount of 75% Ethanol, extract for 1 hour, use 6 times the amount of 75% ethanol for the third time, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of the saponins thorn g/ml, and filter to obtain.

2.8 Preparation of a kind of anti-inflammatory, sterilizing and antipruritic cream:

a) Weigh 9410.4g of carbomer, add it to 90ml of distilled water, after mixing evenly, let it stand to swell fully, form gel a, and set aside;

b) Weigh 0.4g of the ice crystal forming agent, add it into 90ml of distilled water, and after mixing evenly, let it stand to swell fully to form gel b, and set it aside;

c) Take 1.5g of aloe vera oil, 1.5g of perilla seed oil, 1.5g of evening primrose oil, 1.5g of calendula oil, 1.2g of APG type emulsifier SMONTANOV L, and 821.2g of wheat source emulsifier MONTANOV, in a water bath at 85°C Heat it on the pan, use it as the oil phase, and set aside;

d) Take 10ml of distilled water, heat it on a water bath at 85°C, and use it as the water phase for later use;

e) When the temperature of the oil phase and the water phase are the same, add the oil phase into the water phase in a thin stream, and stir while adding until a uniform emulsion matrix 1 is formed;

d) Add gel a and gel b to emulsion base 1, mix well, add 0.55ml of peppermint extract, 0.55ml of wild chrysanthemum extract, 0.55ml of sophora flavescens extract, 0.55ml of white fresh bark extract, 0.6ml of Fuzi extract, 0.55ml of saponins extract, 0.55ml of Cnidium extract, stir and mix evenly, then add 0.2% ethylparaben 75% ethanol solution 1.2ml, add glycerin 3ml, stir and mix evenly, Instant anti-inflammatory, anti-bacterial and anti-itch cream.

Example 3

An anti-inflammatory, sterilizing and antipruritic cream, comprising the following raw materials:

A preparation method for anti-inflammatory, sterilizing and antipruritic emulsifiable cream, comprising the following steps:

3.1 Preparation of peppermint extract

Weigh 12g mint, soak in water for 0.5h, heat and decoct at 100°C for 3 times, add 11 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, and add 6 times the amount for the third time Double the amount of water, extract for 1 hour, filter each time, combine the filtrates, concentrate the volume of the filtrates to 5 times the weight of mint (g/ml), and filter to obtain.

3.2 Preparation of Fructus Cnidii Extract

Weigh 12g of Fructus Cnidii, soak in 65% ethanol for 0.5h, heat and decoct at 100°C for 3 times, add 11 times the amount of 65% ethanol for the first time, extract for 1 hour, add 8 times the amount of 65% ethanol water for the second time , extract 1h, add 6 times the amount of 65% ethanol for the 3rd time, extract 1h, filter each time, combine the filtrate, the volume of the filtrate is concentrated to 5 times (g/ml) of Fructus Cnidii weight, filter to get final product.

3.3 Preparation of wild chrysanthemum extract

Weigh 12g of wild chrysanthemum, soak in 75% ethanol for 0.5h, reflux extraction 3 times, use 11 times the amount of 75% ethanol for the first time, extract for 1h, filter, use 8 times the amount of 75% ethanol for the second time, extract for 1h, and Use 6 times the amount of solvent for three times, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 7 times the weight of the wild chrysanthemum flower g/ml, and filter to obtain the product.

3.4 Preparation of Sophora flavescens extract

Weigh 12g of Sophora flavescens, crush it into a coarse powder, soak it in 70% ethanol for 0.5h, reflux and extract 3 times, use 11 times the amount of solvent for the first time, extract for 1h, filter, and use 8 times the amount of solvent for the second time, extract for 1h, For the third time, use 6 times the amount of solvent, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 6 times the weight of Sophora flavescens g/ml, and filter to obtain the product.

3.5 Preparation of Radix Cortex Extract

Weigh 12g of white fresh skin, crush it into coarse powder, soak it in 85% ethanol for 0.5h, reflux and extract 3 times, use 11 times the amount of solvent for the first time, extract for 1h, filter, and use 8 times the amount of solvent for the second time, extract for 1h For the third time, use 6 times the amount of solvent, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 8 times the weight of white fresh skin g/ml, and filter to obtain.

3.6 Preparation of Kochia chinensis extract

Weigh 12g Kochia scoparia, soak in 75% ethanol for 0.5h, reflux and extract 3 times, first use 11 times the amount of 75% ethanol, extract for 1 hour, filter, and use 8 times the amount of 75% ethanol for the second time, extract for 1 hour, For the third time, use 6 times the amount of 75% ethanol, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 8 times the weight of Kochia scoparia, and filter to obtain the product.

3.7 Preparation of saponins thorn extract

Weigh 12g of saponins, crush into coarse powder, soak in 75% ethanol for 0.5h, reflux and extract 3 times, use 11 times the amount of 75% ethanol for the first time, extract for 1h, filter, and use 8 times the amount of 75% ethanol for the second time Ethanol, extract for 1 hour, use 6 times the amount of 75% ethanol for the third time, extract for 1 hour, filter separately, combine the filtrates, concentrate under reduced pressure to 7 times the weight of the saponins g/ml, and filter to obtain the product.

3.8 Preparation of a kind of anti-inflammatory, sterilizing and antipruritic cream:

a) Weigh 9410.55g of carbomer, add it into 95ml of distilled water, after mixing evenly, let it stand to swell fully, form gel a, and set aside;

b) Weigh 0.55 g of the ice crystal forming agent, add it to 95 ml of distilled water, and after mixing evenly, let it stand to swell fully to form gel b and set it aside;

c) Take 1.2g of aloe vera oil, 1.2g of perilla seed oil, 1.2g of evening primrose oil, 1.2g of calendula oil, 1.1g of APG emulsifier SMONTANOV L, and 821.1g of wheat-derived emulsifier MONTANOV, in a water bath at 90°C Heat it on the pan, use it as the oil phase, and set aside;

d) Take 9ml of distilled water, heat it on a water bath at 90°C, and use it as the water phase for later use;

e) When the temperature of the oil phase and the water phase are the same, add the oil phase into the water phase in a thin stream, and stir while adding until a uniform emulsion matrix 1 is formed;

d) Add gel a and gel b to the emulsion matrix 1, mix well, add 0.6ml of peppermint extract, 0.6ml of wild chrysanthemum extract, 0.6ml of sophora flavescens extract, 0.6ml of white fresh bark extract, 0.6ml of Fuzi extract, 0.6ml of saponins extract, 0.6ml of cnidium extract, stir and mix evenly, then add 0.2% ethylparaben 75% ethanol solution 1.1ml, add glycerin 2.5ml, stir and mix evenly , that is, anti-inflammatory, anti-bacterial and anti-itch cream.

Test example 1

The physicochemical index of embodiment 1,2,3 is as follows:

1.1 Traits

This product is a milky white ointment with suitable viscosity, fine and uniform, and good spreadability.

1.2pH check

Dip a small amount of cream with moistened pH paper, pH 6-7.

1.3 Hot and cold test

Package the cream in a transparent cream bottle and refrigerate it in a refrigerator at 4°C for about a week to observe that there is no delamination. In a constant temperature box at 55°C for 24 hours, there is no phenomenon of stratification, emulsification and odor change.

1.4 Centrifugal test

The cream was packaged in a stoppered test tube and centrifuged at 3000r/min for 20min without delamination.

1.5 Irritation test, allergy test

The back of the mouse was cut off, and the cream prepared in Examples 1, 2, and 3 was applied to the cut-off site respectively, and compared with the unpainted site, the results showed no irritation and allergic reaction.

Get the emulsifiable paste prepared by Examples 1, 2, 3 and apply it on the hands of volunteers (15-65 years old, 25 people) in an appropriate amount, observe after 30 minutes, and there is no redness, eruption, and blistering phenomenon.

1.6 Placement experiment at room temperature

The emulsifiable paste made by embodiment 1,2,3 is placed in the emulsifiable paste bottle, and left standstill at room temperature investigates 6 months, and there is no delamination phenomenon, feels unchanged after using, and smell does not change.

1.7 Medicinal effects

Volunteers (15-65 years old, 25 people) were selected, and the prepared cream was applied to the affected parts of the volunteers. The volunteers generally felt comfortable, and the skin had no special reaction after using it. The affected parts were obviously improved after continuous use.

Test example 2

Investigation on the Comprehensive Effect of the Cream

The effect of the emulsifiable cream produced in Examples 1, 2, and 3 is evaluated by using the trial effect below. Adopt public opinion survey scoring method, select 25 patients in the age group of 15-65 as trial objects, arbitrarily divided into two groups, and apply the emulsifiable paste prepared in Examples 1, 2, and 3 to the affected area respectively. Use twice a day, morning and night, for two weeks. The total score of each effect is 5: 5 is the highest score, which means very good and very satisfied; 4 is good; 3 is acceptable; below 3 is bad and unacceptable. Below are the average scores for each category. The results are shown in Table 1:

Table 1 Comprehensive effect investigation

In summary, the cream prepared by the present invention is delicate and uniform, has good ductility, and has obvious anti-inflammatory, sterilizing, and antipruritic effects.

Claims (9)

1. a kind of emulsifiable paste that anti-inflammation and sterilization is antipruritic, which is characterized in that the antipruritic emulsifiable paste of the anti-inflammation and sterilization is made of following raw material：

Aloe 1-5g

Purple Perilla Seed Oil 1-5g

Evening primrose oil 1-5g

Pot marigold oil 1-5g

Distilled water 107-212ml

APG type emulsifier SMONTANOV L 1-3g

82 1-3g of wheat source emulsifier MONTANOV

Peppermint extracting solution 0.5-1.5ml

Wild chrysanthemum extracting solution 0.5-1.5ml

Radix Sophorae Flavescentis extractive liquid 0.5-1.5ml

Root bark of shaggy-fruited dittany extracting solution 0.5-1.5ml

Fruit of summer cypress extracting solution 0.5-1.5ml

Spina gleditsiae extracting solution 0.5-1.5ml

Frutus cnidii extracting solution 0.5-1.5ml

Ice crystal forming agent 0.1-0.9g

Carbopol 941 0.2-0.8g

Glycerine 1.5-4ml

0.2% ethylparaben, 75% ethanol solution 0.5-1.5ml.

2. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1, which is characterized in that the peppermint extracting solution is to pass through It is prepared by following methods：

It is appropriate to weigh peppermint, soaks 0.15-0.8h, heating, which decocts, in 90-100 DEG C extracts 3 times, the 1st time plus 8-18 times Water is measured, 0.5-2h is extracted, the 2nd time plus 8-15 times measure water, extract 0.5-1.5h, measure water the 3rd time plus 5-12 times, extract 0.5- 1.5h, filters every time, and the volume concentration of merging filtrate, filtrate is filtered to 3-6 times of g/ml of peppermint weight to obtain the final product.

3. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1 or 2, which is characterized in that the frutus cnidii extracting solution It is to be prepared by the following method：

It is appropriate to weigh frutus cnidii, impregnates 0.15-0.8h with 60%-85% ethyl alcohol, is extracted 3 times, the 1st time with 60%-85% alcohol refluxs Add 8-18 times to measure solvent, extract 0.5-2h, measure solvent the 2nd time plus 8-15 times, extract 0.5-1.5h, measures for the 3rd time plus 5-12 times molten Agent is extracted 0.5-1.5h, is filtered every time, merging filtrate, and the volume concentration of filtrate is filtered to 3-6 times of g/ml of frutus cnidii weight To obtain the final product.

4. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1 or 2, which is characterized in that the wild chrysanthemum extracting solution It is to be prepared by the following method：

It is appropriate to weigh wild chrysanthemum, impregnates 0.15-0.8h with 40%-90% alcohol, is extracted 3 times with 40%-90% alcohol refluxs, used for the first time 8-18 times is measured solvent, extracts 0.5-2.5h, and filtering measures solvent with 8-15 times for the second time, extracts 0.5-2.5h, uses 5-12 for the third time Amount solvent again extracts 0.5-1.5h, filters respectively, merging filtrate, the 6-10 times of g/ml for wild chrysanthemum weight is concentrated under reduced pressure, and filters To obtain the final product.

5. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1 or 2, which is characterized in that the Radix Sophorae Flavescentis extractive liquid is It is prepared by the following method：

It takes kuh-seng appropriate, is ground into coarse powder, impregnate 0.15-0.8h with 50%-80% ethyl alcohol, refluxing extraction 3 times uses 8-18 for the first time Amount solvent again extracts 0.5-2.5h, and filtering measures solvent with 8-15 times for the second time, and extraction 0.5-2.5h is measured with 5-12 times for the third time Solvent extracts 0.5-1.5h, filters respectively, merging filtrate, the 6-10 times of g/ml for kuh-seng weight is concentrated under reduced pressure, filters to obtain the final product.

6. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1 or 2, which is characterized in that the root bark of shaggy-fruited dittany extracting solution It is to be prepared by the following method：

It takes the root bark of shaggy-fruited dittany appropriate, is ground into coarse powder, impregnate 0.15-0.8h with 75%-95% ethyl alcohol, refluxing extraction 3 times uses 8- for the first time 18 times of amount solvents, extract 0.5-2.5h, and filtering measures solvent with 8-15 times for the second time, 0.5-2.5h is extracted, for the third time with 5-12 times Solvent is measured, 0.5-1.5h is extracted, filters respectively, merging filtrate, the 6-10 times of g/ml for root bark of shaggy-fruited dittany weight is concentrated under reduced pressure, filtering is .

7. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1 or 2, which is characterized in that the spina gleditsiae extracting solution It is to be prepared by the following method：

It takes spina gleditsiae appropriate, is ground into coarse powder, impregnate 0.15-0.8h with 60%-80% ethyl alcohol, refluxing extraction 3 times uses 8- for the first time 18 times of amount solvents, extract 0.5-2.5h, and filtering measures solvent with 8-15 times for the second time, 0.5-2.5h is extracted, for the third time with 5-12 times Solvent is measured, 0.5-1.5h is extracted, filters respectively, merging filtrate, the 6-10 times of g/ml for spina gleditsiae weight is concentrated under reduced pressure, filtering is .

8. the antipruritic emulsifiable paste of anti-inflammation and sterilization according to claim 1 or 2, which is characterized in that the fruit of summer cypress extracting solution It is to be prepared by the following method：

It taking the fruit of summer cypress appropriate, impregnates 0.15-0.8h with 70%-90% ethyl alcohol, refluxing extraction 3 times measures solvent with 8-18 times for the first time, 0.5-2.5h is extracted, filtering measures solvent with 8-15 times for the second time, extracts 0.5-2.5h, measures solvent with 5-12 times for the third time, extracts 0.5-1.5h is filtered respectively, merging filtrate, and the 6-10 times of g/ml for fruit of summer cypress weight is concentrated under reduced pressure, filters to obtain the final product.

9. a kind of preparation method of the antipruritic emulsifiable paste of claim 1-8 any one of them anti-inflammation and sterilizations, which is characterized in that described Preparation method includes the following steps：

a）Weigh Carbopol 941 0.2-0.8g, be added in the distilled water of 50-100ml, it is to be mixed uniformly after, standing allow it to fill Divide swelling, forms gel a, for use；

b）Weigh ice crystal forming agent 0.1-0.9g, be added in the distilled water of 50-100ml, it is to be mixed uniformly after, standing allow it to fill Divide swelling, forms gel b, for use；

c）Take aloe 1-5g, Purple Perilla Seed Oil 1-5g, evening primrose oil 1-5g, pot marigold oil 1-5g, APG type emulsifier SMONTANOV L 1-3g, 82 1-3g of wheat source emulsifier MONTANOV, are heated on 60-90 DEG C of water-bath, as oil Phase, it is spare；

d）Distilled water 7-12ml is taken, is placed on 60-90 DEG C of water-bath and heats, it is spare as oil phase；

e）It waits for that oil phase is identical with water phase temperature, oil phase is added in thread shape in water phase, it is stirring while adding until being formed uniform Emulsion bases 1；

d）Gel a, gel b are added into emulsion bases 1, after mixing, peppermint extracting solution 0.5-1.5ml, wild chrysanthemum is added Extracting solution 0.5-1.5ml, Radix Sophorae Flavescentis extractive liquid 0.5-1.5ml, root bark of shaggy-fruited dittany extracting solution 0.5-1.5ml, fruit of summer cypress extracting solution 0.5- 1.5ml, spina gleditsiae extracting solution 0.5-1.5ml, frutus cnidii extracting solution 0.5-1.5ml, are uniformly mixed, add 0.2% Ni Bo 75% ethanol solution 0.5-1.5ml of golden ethyl ester, glycerol adding 1.5-4ml, are uniformly mixed to get the antipruritic breast of anti-inflammation and sterilization Cream.