CN105105812A - Intracranial aneurysm interventional embolization treatment device - Google Patents

Abstract

The invention discloses an interventional embolization treatment device for an intracranial aneurysm, which includes an occluder and a delivery device. The occluder is a mesh woven from metal wires with memory effect or high-elastic polymer wires and developing wires. The occluder consists of upper and lower parts, which are the upper intratumoral part and the lower extratumoral part, and the upper intratumoral part and the lower extratumoral part are connected together to form a covering space covering the neck of the aneurysm; The device includes a delivery catheter and a delivery guide wire. During delivery, the occluder is elongated and placed in the delivery catheter, and the delivery guide wire is connected to the tail of the occluder. The invention can induce thrombus formation in the tumor, promote the repair of blood vessels in the neck of the tumor, thereby achieving the purpose of curing the aneurysm, and has no obvious influence on the tumor-bearing blood vessels and normal branches.

Description

Interventional embolization treatment device for intracranial aneurysm

technical field

The invention relates to the technical field of medical devices, in particular to an intracranial aneurysm interventional embolization treatment device.

Background technique

A large number of autopsy or angiographic studies show that the incidence of intracranial aneurysms in the entire population is as high as 2%-4%. Once the intracranial aneurysm ruptures and bleeds, its mortality rate and disability rate are relatively high. If two hemorrhages occur, the mortality rate is as high as 60%-80%. This disease seriously threatens human life and health. Therefore, exploring a safer and more effective method of treating intracranial aneurysms has also become a key research content in this field.

In 1991, Guglielmi et al reported for the first time electrolytic coil embolization in the treatment of intracranial aneurysms. The interventional treatment of intracranial aneurysms has gone through the concept of simple coil embolization in the 1990s, the concept of balloon or stent-assisted coil embolization in the early 2000s, and the current concept of using blood flow-guiding stents to reconstruct the parent artery. These changes in treatment concepts have gradually increased the complete cure rate of intracranial aneurysm aneurysms, and gradually reduced the recurrence rate of the aneurysm neck, but it has also brought about the risk of occlusion of the normal branch vessels covered by the parent artery and stent. The emergence of intra-aneurysm embolization balls (WEB, SequentMedical, AlisoViejo, California) can effectively avoid the occlusion of normal branches around the aneurysm neck. It is still difficult to solve the problem of residual tumor. At present, there is a need for an interventional device that can effectively occlude the aneurysm, especially strengthen the repair of blood vessels in the neck of the aneurysm, and has less impact on the parent artery and normal branches near the aneurysm. In the study on the treatment of intracranial aneurysms with blood flow steering stents, the applicant found that different shapes of stents and different release processes can adjust the metal coverage of the aneurysm neck, which provides a basis for the design of interventional materials that simply increase the metal coverage of the aneurysm neck. theoretical basis. With the continuous development of cardiovascular interventional technology and materials, cases such as congenital atrial septal defect can achieve the purpose of occluding the gap through interventional occlusion materials, but this occlusion device for immediate occlusion of congenital atrial septal defect is suitable for patients with large Delivery in the delivery catheter cannot be delivered in a microcatheter with a diameter of about 1mm in the intracranial intervention material. The blood flow guiding stent and the intravascular embolic ball (WEB) can be stretched and elongated to reach the intracranial lesion through the microcatheter. According to the current advantages and disadvantages of intracranial aneurysm interventional therapy, we design an interventional occlusion device mainly for the repair of intracranial aneurysm neck by referring to the design concept of interventional materials in cardiovascular medicine.

Contents of the invention

Aiming at the defects of the prior art, the present invention discloses an interventional embolization treatment device for intracranial aneurysms, which can not only effectively occlude the aneurysm, strengthen the repair of blood vessels in the neck of the aneurysm, but also have less influence on the parent artery and normal branch blood vessels near the aneurysm .

In order to solve the technical problem, the technical solution adopted by the present invention is: an interventional embolization treatment device for intracranial aneurysm, including an occluder and a delivery device, the occluder is made of a metal wire with a memory effect or a highly elastic It is a net-shaped occluder woven by polymer silk and developing silk. The occluder consists of upper and lower parts, which are the upper part inside the tumor and the lower part outside the tumor. The upper part inside the tumor and the lower part outside the tumor are connected together to form a package. Covering the space covering the neck of the aneurysm, the upper end and the lower end of the occluder are respectively provided with a head-end development point and a tail-end development point; the delivery device includes a delivery catheter and a delivery guide wire. When delivering, the occluder is pulled Long placed in the delivery catheter, the delivery guide wire is connected to the tail of the occluder.

Further, the inside of the upper aneurysm of the occluder is divided into a spherical or hemispherical occluder close to the inner wall of the aneurysm, and the outer part of the lower aneurysm is divided into a ring of annular occluders close to the inner wall of the parent artery. The lower end of the part is gathered inwardly and connected with the lower extratumoral part, and the junction of the upper intratumoral part and the lower extratumoral part forms a covering space covering the neck of the aneurysm.

Further, the diameter of the upper end of the upper intratumoral part is larger than the diameter of the junction of the upper intratumoral part and the lower extratumoral part, and the lower diameter of the lower extratumoral part is larger than the diameter of the junction of the upper intratumoral part and the lower extratumoral part .

Further, the diameter of the junction of the upper intratumoral part and the lower extratumoral part is 1-5 mm, and the upper diameter of the upper intratumoral part and the lower diameter of the lower extratumoral part are 1-2 mm larger than the diameter of the junction.

Further, the upper end of the upper intratumoral part is sunken downward, and the lower end of the lower extratumoral part is sunken upward.

Further, the head of the delivery catheter is warped into the aneurysm, and the warpage height is 4-8 mm according to the diameter of the aneurysm and the diameter of the parent artery.

Further, the diameter of the delivery catheter is 1-2mm.

Beneficial effects of the present invention: the present invention includes an occluder and a delivery device. The occluder is a net-shaped occluder woven from a metal wire with a memory effect or a highly elastic polymer wire and a developing wire. The blood flow in the aneurysm neck induces the formation of intratumoral thrombus and promotes the repair of blood vessels in the aneurysm neck, so as to achieve the purpose of curing the aneurysm; and the occluder includes the upper intratumoral part and the lower extratumoral part, the upper intratumoral part and the lower extratumoral part Parts are connected together to form a covered space covering the aneurysm, that is, a "sandwich" type of reinforcement repair is formed at the neck of the aneurysm. By locally increasing the effective metal coverage of the aneurysm neck, it can effectively prevent the aneurysm neck from being damaged after interventional treatment. The problem of local recurrence; when the occluder is released at the neck of the aneurysm, the stimulation to the aneurysm wall is small, and the upper part of the aneurysm is close to the inner wall of the aneurysm, which can evenly strengthen the strength of the aneurysm wall and effectively prevent the rupture of the aneurysm during operation and postoperative recurrence; only the lower end of the occluder outside the tumor is close to the inner wall of the parent artery, that is, after the occluder occludes the aneurysm neck, there is less exposure in the normal parent artery, which affects the parent vessel and normal branches Smaller, it can effectively solve the problem of parent artery stenosis or embolism caused by traditional intravascular stents.

Description of drawings

Figure 1 is a schematic diagram of the structure of the occluder after it is released in vitro;

Fig. 2 is a schematic diagram of delivery and release of the occluder in the delivery device;

Fig. 3 is the treatment effect figure of aneurysm of the present invention;

In the figure: 1. Occluder, 11. Intratumoral part at the upper end, 12. Extratumoral part at the lower end, 13. Development point at the head end, 14. Development point at the tail end, 15. Covering space, 2. Delivery device, 21. Delivery catheter, 22, delivery guide wire, 3, aneurysm, 31, aneurysm neck, 4, parent artery.

Detailed ways

The present invention will be further described and defined below in conjunction with the accompanying drawings and specific embodiments.

As shown in Figures 1 and 2, an interventional embolization treatment device for intracranial aneurysms includes an occluder 1 and a delivery device 2. The occluder 1 is made of a metal wire with a memory effect or a high-elastic polymer wire. A mesh occluder woven with developing silk, the occluder 1 includes upper and lower parts, which are the upper intratumoral part 11 and the lower extratumoral part 12, and the upper intratumoral part 11 and the lower extratumoral part 12 are connected together to form Covering the covering space 15 covering the neck 31 of the aneurysm, the upper end and the lower end of the occluder 1 are respectively provided with a head end development point 13 and a tail end development point 14; the delivery device 2 includes a delivery catheter 21 and a delivery guide wire 22 During delivery, the occluder 1 is elongated and placed in the delivery catheter 21 , and the delivery guide wire 22 is connected to the tail of the occluder 1 .

In this embodiment, the upper intratumoral part 11 of the occluder 1 is a hemispherical occluder close to the inner wall of the aneurysm 3, the upper intratumoral part 11 is sunken downwards, and the lower extratumoral part 12 is a circle close to the aneurysm. The annular occluder on the inner wall of the parent artery 4, the lower end of the upper intratumoral part 11 is drawn inwardly and connected with the lower extratumoral part 12, and the junction of the upper intratumoral part 11 and the lower extratumoral part 12 forms a covered aneurysm The covering space 15 of the neck 31 is to form a "sandwich" reinforcement repair at the neck 31 of the aneurysm. By locally increasing the effective metal coverage of the neck 31 of the aneurysm, it can effectively prevent the aneurysm neck from becoming damaged after interventional treatment. Recurrence problem.

In this embodiment, the upper diameter of the upper intratumoral part 11 and the lower diameter of the lower extratumoral part 12 are greater than the diameter of the connection between the upper intratumoral part 11 and the lower extratumoral part 12 . Specifically, according to the size of the aneurysm and the diameter of the aneurysm neck, the diameter of the connection between the upper intratumoral part 11 and the lower extratumoral part 12 of the occluder is designed to be 1-5mm, and the diameter of the lower end of the lower extratumoral part is 2-5mm. , the diameter of the upper end of the upper intratumoral part is 2-7mm.

In this embodiment, the head of the delivery catheter is warped into the aneurysm, and the warpage height is 4-8 mm according to the diameter of the aneurysm and the diameter of the parent artery. The diameter of the delivery catheter is 1-2 mm.

When using the interventional embolization treatment device for intracranial aneurysms, the occluder 1 that has been fabricated and shaped outside the body is first elongated and put into the delivery catheter 21, and then the tail of the occluder 1 is connected with the delivery guide wire 22, and the occluder 1 is passed through the delivery guide. The wire 22 is delivered to the occluder 1 . The head end of the delivery catheter 21 first reaches the lesion, and then the occluder 1 also arrives at the lesion under the delivery of the delivery guide wire 22, and is released into an in vitro release shape by electrolysis or mechanical release. During the release process, the upper intratumoral part 11 of the occluder 1 is in the aneurysm cavity, and the lower extratumoral part 12 is in the parent artery 4 . The entire delivery and release process is released under the digital subtraction angiography machine, and the position and shape of the occluder are displayed through the development point and the development wire. In the catheter 21, until the release position is satisfied, the following operations can be performed.

As shown in FIG. 3 , it shows the state that the occluder 1 has been released in the aneurysm. The occluder 1 increases the actual metal coverage of the neck 31 of the aneurysm, while the exposure in the parent artery 4 is less, and has no obvious influence on the parent vessel and normal branches. The occluder 1 induces thrombus formation in the tumor neck by interfering with the blood flow in the neck of the tumor, and promotes the repair of blood vessels in the neck of the tumor, thereby achieving the purpose of curing the aneurysm.

The above descriptions are only the basic principles and preferred embodiments of the present invention, changes and improvements made by those skilled in the art according to the principles of the present invention should belong to the protection scope of the present invention.

Claims (7)

1. An interventional embolization treatment device for intracranial aneurysms, characterized in that: it comprises an occluder and a delivery device, and the occluder is woven into a metal wire with a memory effect or a high-elastic polymer wire and a developing wire The occluder consists of upper and lower parts, which are the upper intratumoral part and the lower extratumoral part. The upper intratumoral part and the lower extratumoral part are connected together to form a covering space covering the neck of the aneurysm. The upper end and the lower end of the occluder are respectively provided with a head-end development point and a tail-end development point; the delivery device includes a delivery catheter and a delivery guide wire. During delivery, the occluder is elongated and placed in the delivery catheter, and the delivery guide The wire is connected to the end of the occluder. 2. The intracranial aneurysm interventional embolization treatment device according to claim 1, characterized in that: the inside of the upper end of the occluder is divided into a spherical or hemispherical blocker that is close to the inner wall of the aneurysm, and the lower end is outside the aneurysm. Part of it is a ring-shaped occluder close to the inner wall of the parent artery, the lower end of the upper intratumoral part is drawn inwardly and connected with the lower extratumoral part, and the junction of the upper intratumoral part and the lower extratumoral part forms a covered artery The covering space of the neck of the aneurysm. 3. The intracranial aneurysm interventional embolization treatment device according to claim 2, characterized in that: the diameter of the upper end of the upper end intratumoral part is greater than the diameter of the connection between the upper end intratumoral part and the lower end extratumoral part, and the lower end extratumoral part The diameter of the lower end of the portion is greater than the diameter at the junction of the upper intratumoral portion and the lower extratumoral portion. 4. The intracranial aneurysm interventional embolization treatment device according to claim 3, characterized in that: the diameter of the junction of the upper end intratumoral part and the lower end extratumoral part is 1-5mm, and the upper end diameter and lower end diameter of the upper end intratumoral part The diameter of the lower end of the extratumoral part is 1-2 mm larger than the diameter of the junction. 5 . The device for interventional embolization treatment of intracranial aneurysms according to claim 4 , characterized in that: the upper end of the upper intratumoral part is sunken downward, and the lower end of the lower extratumoral part is sunken upward. 6 . 6. The intracranial aneurysm interventional embolization treatment device according to claim 1 or 5, characterized in that: the head of the delivery catheter is warped into the aneurysm, and according to the diameter of the aneurysm and the diameter of the parent artery, the warping The height is 4-8mm. 7. The device for interventional embolization treatment of intracranial aneurysm according to claim 6, characterized in that: the diameter of the delivery catheter is 1-2 mm.