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CN105056074A - Prescription for treating arrhythmia - Google Patents

Prescription for treating arrhythmia Download PDF

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Publication number
CN105056074A
CN105056074A CN201510537979.0A CN201510537979A CN105056074A CN 105056074 A CN105056074 A CN 105056074A CN 201510537979 A CN201510537979 A CN 201510537979A CN 105056074 A CN105056074 A CN 105056074A
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parts
radix
subsequent use
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slow fire
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霍同颜
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Abstract

The invention discloses a prescription for treating the arrhythmia. The prescription comprises, by weight, 9 parts to 16 parts of polygala tenuifolia, 11 parts to 15 parts of rosa chinensis, 8 parts to 12 parts of ficus lyrata, 9 parts to 13 parts of drumfishes, 7 parts to 14 parts of notopterygium incisum, 10 parts to 13 parts of phyllanthus virgatus, 8 parts to 14 parts of flowerbelge, 6 parts to 13 parts of alpinia katsumadai, 10 parts to 14 parts of rohdea japonica, 9 parts to 12 parts of trachycarpus wood, 6 parts to 12 parts of red sage roots, 7 parts to 13 parts of evolvulus alsinoides, 9 parts to 14 parts of radix paeoniae alba, 6 parts to 15 parts of gordon euryale leaves and 8 parts to 13 parts of sophora fruits. The prescription further has the advantages that traditional Chinese medicine theories are combined with the modern medicine, the multiple traditional Chinese medicinal materials are carefully selected, symptoms of the arrhythmia can be remarkably improved, the oxygen shortage resistance of cardiac muscles is improved, and the obvious improvement effect on the myocardial ischemia is achieved; product medicine prepared according to the prescription is scientific in compatibility, convenient to prepare, rapid in effect taking after being taken, free of toxic and side effects and free of adverse effects after being taken.

Description

One treats ARR prescription
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of ARR prescription.
Background technology
It is fast or slow that " arrhythmia " refers to heart beating, exceeded general range.The tachycardia that abnormality of cardiac automaticity or conductive impairment cause, bradycardia or arrhythmia; Psychentonia, a large amount of smoking, to drink, drink dense tea or coffee, overtired, serious insomnia etc. normal be ARR risk factor; Arrhythmia is more common in cardiac especially, also often occurs in anesthesia, operation or Post operation.
ARR cardinal symptom has: cardiopalmus (heart beating that a kind of patient can feel self accelerates and increases the weight of), heart beating is slow, irregular heart beating, between heart beating, heart suspends, the arrhythmia that serious disease causes, many with some symptoms, commonly have that dizziness, uncomfortable in chest, chest pain, out of breath, hyperhidrosis, face are pale, cold extremities, tic, stupor etc.ARR harm: 1, arrhythmia can make blood circulation not normal: when there is arrhythmia, atrium and ventricular systole routine change, can make cardiac output decline about 30%, the symptom such as cause patient to have a guilty conscience, uncomfortable in chest, unable.2, arrhythmia more seriously can cause that sinus stops winning, sino atrial block and bradycardia, there is tachycardia complex disease (also known as slow-fast syndrome).3, arrhythmia can cause sudden death: it is arrhythmia that the maximum reason of sudden death occurs, and wherein quivers with ventricular tachycardia, room and conduction block causes overworked dead incidence rate the highest.
Application publication number CN103705733A(application number 201410021576.6) Chinese invention patent document disclose one and treat ARR Chinese medicinal capsule and preparation method thereof, be made up of the raw material of following weight portion: Rhizoma Polygonati 18-33, Radix Bupleuri 15-32, Fructus Schisandrae Chinensis 6-15, Radix Scutellariae 25-35, Fructus Corni 30-45, Radix Rehmanniae Preparata 24-36, Poria 17-30, Radix Polygalae 21-31, Radix Berberidis 35-42, Rhizoma Acori Graminei 3-8, Fructus Cannabis 29-37, Radix Adenophorae 9-14, Concha Ostreae 4-12, Mel Jujubae 3-9.Application publication number CN103961677A(application number 201410233369.7) Chinese invention patent document disclose one and treat ARR Traditional Chinese drug mixture, be made up of the raw material of Chinese medicine of following composition by weight: Cortex Cinnamomi 30 parts, Ramulus Cinnamomi 12 parts, Concha Ostreae 30 parts, Radix Paeoniae Rubra 10 parts, the Radix Astragali 30 parts, 20 parts, Fructus Jujubae, Os Draconis 30 parts, 6 parts, Rhizoma Zingiberis Recens, Radix Aconiti Lateralis Preparata 15 parts, 6 parts, Radix Glycyrrhizae, 20 parts, Poria, Rhizoma Pinelliae 18 parts.Application publication number CN104644846A(application number 201310575732.9) Chinese invention patent document disclose one and be used for the treatment of ARR Chinese medicine, be made up of following Chinese medicine ingredients: Fructus Ligustri Lucidi 30-45 gram, Arillus Longan 5-10 gram, Semen Ziziphi Spinosae 12-16 gram, Colla Corii Asini 8-12 gram, Radix Polygalae 15-20 gram, Radix Sophorae Flavescentis 30-40 gram, root of subprostrate sophora 18-25 gram, Ramulus Uncariae Cum Uncis 15-18 gram, Aconitum carmichjaelii Debx. 9-15 gram.
Although the medicine provided in prior art has certain curative effect on treatment arrhythmia, part prescription more or less can give the gastrointestinal of patient, Liver and kidney brings certain toxic and side effects.Therefore research and develop a kind of short treating period, determined curative effect, the Chinese medicine that safety has no side effect has important practical significance.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, taking convenience, treat ARR prescription safely and effectively.This Chinese medicinal formulae determined curative effect is convenient to Clinical practice.
Technical scheme of the present invention is:
One treats ARR prescription, is prepared from by following bulk drugs, is weight portion: Radix Polygalae 9-16; Flos Rosae Chinensis 11-15; Radix fici panduratae 8-12; Carnis Pseudosciaenae 9-13; Rhizoma Et Radix Notopterygii 7-14; Phyllanthus simplex Retz. 10-13; Coagulum Opuntiae sucus 8-14; Semen Alpiniae Katsumadai 6-13; Rohdea japonica Roth 10-14; Lignum Trachycarpi 9-12; Radix Lantanae Camaraev 6-12; Herba Evolvuli Alsinoides 7-13; Radix Paeoniae Alba 9-14; Folium Euryales 6-15; Fructus Sophorae 8-13.
In preferred scheme, Radix Polygalae 11-13; Flos Rosae Chinensis 12-14; Radix fici panduratae 9-11; Carnis Pseudosciaenae 10-12; Rhizoma Et Radix Notopterygii 9-12; Phyllanthus simplex Retz. 11-12; Coagulum Opuntiae sucus 10-12; Semen Alpiniae Katsumadai 8-11; Rohdea japonica Roth 11-13; Lignum Trachycarpi 10-11; Radix Lantanae Camaraev 8-10; Herba Evolvuli Alsinoides 9-10; Radix Paeoniae Alba 10-13; Folium Euryales 9-12; Fructus Sophorae 10-11.
Be more preferably, Radix Polygalae 12; Flos Rosae Chinensis 13; Radix fici panduratae 10; Carnis Pseudosciaenae 11; Rhizoma Et Radix Notopterygii 10.5; Phyllanthus simplex Retz. 11.5; Coagulum Opuntiae sucus 11; Semen Alpiniae Katsumadai 9.5; Rohdea japonica Roth 12; Lignum Trachycarpi 10.5; Radix Lantanae Camaraev 9; Herba Evolvuli Alsinoides 9.5; The Radix Paeoniae Alba 11.5; Folium Euryales 10.5; The Fructus Sophorae 10.5.
One treats ARR prescription, and be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use; Coagulum Opuntiae sucus is placed in mortar porphyrize powder, for subsequent use;
(2) Phyllanthus simplex Retz., Lignum Trachycarpi, Herba Evolvuli Alsinoides and Folium Euryales mixing, add yellow wine and mix thoroughly, add a cover vexed 12-20 minute (preferably adding a cover vexed 16 minutes), take out, slow fire heat, fry to wine be sucked into degree, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Rohdea japonica Roth, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in medicine pot, add cold water and do not have powder about 4cm, soak under room temperature 2-4 hour (soaking 3 hours under being preferable over room temperature), then the crude drug after step (2) process is added, big fire heated and boiled, turn little fire to decoct 35-55 minute (preferably turning little fire to decoct 45 minutes), filter, filtrate is for subsequent use;
(4) the Shishou flesh of fish is placed in stockpot, add the clear water (preferably adding the clear water of 3.5 times amount) of 2.5-4.5 times amount, slow fire boiling 10-18 minute (preferred slow fire boiling 14 minutes), then clean Chinese rose petal is added, continue slow fire boiling 8-16 minute (preferred slow fire boiling 12 minutes), filter, filtrate is for subsequent use;
(5) by step (3) and the mixing of (4) gained filtrate, be evaporated to the half of original volume, add the raw material medicated powder after step (1) process, mixing, sterilizing encapsulates, and to obtain final product.
Above-mentioned a kind of preparation method for the treatment of ARR decoction, preferred scheme is, in step (2), the amount of yellow wine is the 0.45-0.75 of raw material dose doubly (amount of preferred yellow wine is 0.55-0.65 times of raw material dose, and the amount of the yellow wine be more preferably is 0.6 times of raw material dose).
Above-mentioned a kind of preparation method for the treatment of ARR decoction, preferred scheme is, in step (3), the time of big fire heated and boiled is 7-17 minute (time of preferred big fire heated and boiled is 10-14 minute, and the time of the big fire heated and boiled be more preferably is 12 minutes).
The preparation method of described capsule is:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use;
(2) Flos Rosae Chinensis and Folium Euryales mixing, add the Mel after dilution, slow fire fried dry, take out, grind to the powder, for subsequent use; The Shishou flesh of fish is put on smokeless intense fire, ashing, and palpus sustainability, together smashs to pieces with Coagulum Opuntiae sucus, and be ground into fine powder, for subsequent use;
(3) by the raw material powder mixing after step (1) and (2) process, sieve, obtain mixed powder, for subsequent use;
(4) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Rohdea japonica Roth, Lignum Trachycarpi, Radix Lantanae Camaraev, Herba Evolvuli Alsinoides grass and the Radix Paeoniae Alba are placed in Chinese medicament extracting device, take the concentration of 4-7 times of raw material dose as the ethanol of 55% be solvent (be preferably the ethanol of 55% with the concentration of 5.5 times of raw material doses be solvent), heating and refluxing extraction 40-70 minute (preferred heating and refluxing extraction 55 minutes), filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.22-1.25, for subsequent use;
(5) step (3) gained mixed powder is joined in above-mentioned thick paste, mechanical agitation, add simultaneously mass fraction be 10% lactose fine powder, mass fraction be 7.5% microcrystalline Cellulose and mass fraction be the magnesium trisilicate of 4.5%, mix homogeneously, granulate, granulate, dry, incapsulate shell, to obtain final product.
Above-mentioned a kind of preparation method for the treatment of ARR capsule, preferred scheme is, the middle 85-135 mesh sieve excessively of step (3) (preferred 95-125 mesh sieve excessively, mistake 110 mesh sieve be more preferably).
The preparation method of described thick paste agent is:
(1) Flos Rosae Chinensis, Semen Alpiniae Katsumadai, Folium Euryales and the Fructus Sophorae are placed in traditional Chinese medicine drying device, in 50-60 DEG C of dry 2-5 hour (being preferable over 55 DEG C of dryings 3.5 hours), taking out, are ground into fine powder, for subsequent use;
(2) get the Shishou flesh of fish and be placed in container, add Sucus Zingberis and yellow wine is mixed thoroughly, vexed 15-25 minute (preferably vexed 20 minutes), take out, slow fire heats, shallow fry until both sides turn golden brown, rubs, for subsequent use; Coagulum Opuntiae sucus is smashed to pieces and is ground into fine powder, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Herba Evolvuli Alsinoides, Rohdea japonica Roth, Lignum Trachycarpi, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in hermetic container, the mass fraction adding 4-6 times amount is the ethanol of 60% (mass fraction preferably adding 5 times amount is the ethanol of 60%), sealing lixiviate 3-7 days (preferably sealing lixiviate 5 days), filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.12-1.15, for subsequent use;
(4) joined in above-mentioned clear paste by the crude drug after step (1) and (2) process, stir, high temperature sterilize, encapsulation, to obtain final product.
The preparation method of described pill is:
(1) the Shishou flesh of fish, Semen Alpiniae Katsumadai, Herba Evolvuli Alsinoides and Flos Rosae Chinensis are placed in stockpot, add cold water and do not have medical material 3-5cm, then in cold water, add the yellow wine (preferably adding the yellow wine of 16% raw material dose) of 12%-20% raw material dose, slow fire heating decocts 25-45 minute (preferred slow fire heating decoction 35 minutes), filter, filtrate reduced in volume is to 1/3 of original volume, for subsequent use;
(2) get Lignum Trachycarpi, Rohdea japonica Roth, the Radix Paeoniae Alba and Folium Euryales mixing, add 11% raw material dose Sucus Zingberis mix thoroughly, after Sucus Zingberis is sucked, slow fire heats, fried dry, takes out and dries in the air cool, smash to pieces for subsequent use; Get the Fructus Sophorae and Coagulum Opuntiae sucus is cleaned respectively, adding the mass fraction after dilution is 5% refined honey, mixes thoroughly, braised through, puts in parch container, and slow fire is fried to crust light, and tack-free is degree, and taking-up is dried, and smashs into fine powder to pieces, for subsequent use;
(3) getting Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz. and Radix Lantanae Camaraev is placed in medicine pot, add the clear water (preferably adding the clear water of 5.5 times amount) of 4-7 times amount, slow fire heating decoction twice, first time decocts 18-30 minute (preferably first time decocts 24 minutes), second time decocts 10-20 minute (preferably second time decocts 15 minutes), merges twice decocting liquid, filters, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.20-1.25, for subsequent use;
(4) by the raw material medicated powder after step (1) gained filtrate and step (2) process, join in above-mentioned thick paste, mechanical agitation, add sucrose fine and corn starch, mix homogeneously simultaneously, be processed into the pill of Semen Firmianae size, obtain final product.
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention combines according to Chinese medicine traditional theory and modern medicine, and selected plurality of Chinese, can significantly improve arrhythmia symptom, strengthens myocardial hypoxia tolerance, also improves significantly to myocardial ischemia;
2,this prescription has QI invigorating Gu Mai, unimpeded heart arteries and veins, the convergence motive, tranquillizing and allaying excitement, effect of promoting blood circulation to remove blood stasis;
3,product compatibility of drugs science of the present invention, easy to prepare, take rear instant effect, have no side effect, have no adverse reaction after taking medicine.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1one treats ARR prescription, is prepared from by following bulk drugs, is weight portion (55g/ part): Radix Polygalae 9 parts; Flos Rosae Chinensis 11 parts; Radix fici panduratae 8 parts; Carnis Pseudosciaenae 9 parts; Rhizoma Et Radix Notopterygii 7 parts; Phyllanthus simplex Retz. 10 parts; Coagulum Opuntiae sucus 8 parts; Semen Alpiniae Katsumadai 6 parts; Rohdea japonica Roth 10 parts; Lignum Trachycarpi 9 parts; Radix Lantanae Camaraev 6 parts; 7 parts, Herba Evolvuli Alsinoides; The Radix Paeoniae Alba 9 parts; Folium Euryales 6 parts; The Fructus Sophorae 8 parts.
A kind of preparation method for the treatment of ARR decoction is:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use; Coagulum Opuntiae sucus is placed in mortar porphyrize powder, for subsequent use;
(2) Phyllanthus simplex Retz., Lignum Trachycarpi, Herba Evolvuli Alsinoides and Folium Euryales mixing, the yellow wine adding 0.45 times of raw material dose is mixed thoroughly, adds a cover vexed 12 minutes, take out, slow fire heat, fry to wine be sucked into degree, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Rohdea japonica Roth, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in medicine pot, add cold water and do not have powder about 4cm, soak 2 hours under room temperature, then the crude drug after step (2) process is added, big fire heated and boiled 7 minutes, turn little fire to decoct 35 minutes, filter, filtrate is for subsequent use;
(4) be placed in stockpot by the Shishou flesh of fish, add the clear water of 2.5 times amount, slow fire boiling 10 minutes, then add clean Chinese rose petal, continue slow fire boiling 8 minutes, filter, filtrate is for subsequent use;
(5) by step (3) and the mixing of (4) gained filtrate, be evaporated to the half of original volume, add the raw material medicated powder after step (1) process, mixing, sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, and each 180-200mL, takes after warm, 7 days courses for the treatment of.
embodiment 2one treats ARR prescription, is prepared from by following bulk drugs, is weight portion (35g/ part): Radix Polygalae 16 parts; Flos Rosae Chinensis 15 parts; Radix fici panduratae 12 parts; Carnis Pseudosciaenae 13 parts; Rhizoma Et Radix Notopterygii 14 parts; Phyllanthus simplex Retz. 13 parts; Coagulum Opuntiae sucus 14 parts; Semen Alpiniae Katsumadai 13 parts; Rohdea japonica Roth 14 parts; Lignum Trachycarpi 12 parts; Radix Lantanae Camaraev 12 parts; 13 parts, Herba Evolvuli Alsinoides; The Radix Paeoniae Alba 14 parts; Folium Euryales 15 parts; The Fructus Sophorae 13 parts.
A kind of preparation method for the treatment of ARR capsule is:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use;
(2) Flos Rosae Chinensis and Folium Euryales mixing, add the Mel after dilution, slow fire fried dry, take out, grind to the powder, for subsequent use; The Shishou flesh of fish is put on smokeless intense fire, ashing, and palpus sustainability, together smashs to pieces with Coagulum Opuntiae sucus, and be ground into fine powder, for subsequent use;
(3) by the raw material powder mixing after step (1) and (2) process, cross 110 mesh sieves, obtain mixed powder, for subsequent use;
(4) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Rohdea japonica Roth, Lignum Trachycarpi, Radix Lantanae Camaraev, Herba Evolvuli Alsinoides grass and the Radix Paeoniae Alba are placed in Chinese medicament extracting device, take the concentration of 5.5 times of raw material doses as the ethanol of 55% be solvent, heating and refluxing extraction 55 minutes, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.23, for subsequent use;
(5) step (3) gained mixed powder is joined in above-mentioned thick paste, mechanical agitation, add simultaneously mass fraction be 10% lactose fine powder, mass fraction be 7.5% microcrystalline Cellulose and mass fraction be the magnesium trisilicate of 4.5%, mix homogeneously, granulate, granulate, dry, incapsulate shell, to obtain final product.
The instructions of taking of gained capsule of the present invention is: every day three times, each 3-4 grain, and warm water takes, 7 days courses for the treatment of.
Model case: grandson XX, female, 55 years old, teacher.Patient's readme: occurred the symptoms such as uncomfortable in chest, nervous without obvious inducement before 2 years, especially in fatigue nervous, tachypnea symptom aggravation afterwards, after having a rest a little, symptom can spontaneous remission.Once in certain hospital's drug administration treatment local, symptom had no and alleviated, and introduced by friend, comes my institute check treatment on June 11st, 2010.Check: patient's green around the gills, uncomfortable in chest, tachypnea symptom happens occasionally, and sleeps poor, pale tongue, thin fur, thready pulse, heart rate 112 times/min.Electrocardiogram is pointed out: sinus tachycardia.
Take the present embodiment gained one and treat ARR capsule, instructions of taking: every day three times, each 3-4 grain, warm water takes, 7 days courses for the treatment of.After taking two courses for the treatment of, patient is nervous, tachypnea disappears, and other symptom obviously alleviates; After continuing to take two courses for the treatment of, all cards disappear, Electrocardioscopy, recover normal.Pay a return visit after three months, patient body is healthy, without recurrence.
embodiment 3one treats ARR prescription, is prepared from by following bulk drugs, is weight portion (50g/ part): Radix Polygalae 11 parts; Flos Rosae Chinensis 12 parts; Radix fici panduratae 9 parts; Carnis Pseudosciaenae 10 parts; Rhizoma Et Radix Notopterygii 9 parts; Phyllanthus simplex Retz. 11 parts; Coagulum Opuntiae sucus 10 parts; Semen Alpiniae Katsumadai 8 parts; Rohdea japonica Roth 11 parts; Lignum Trachycarpi 10 parts; Radix Lantanae Camaraev 8 parts; 9 parts, Herba Evolvuli Alsinoides; The Radix Paeoniae Alba 10 parts; Folium Euryales 9 parts; The Fructus Sophorae 10 parts.
A kind of preparation method for the treatment of ARR thick paste agent is:
(1) Flos Rosae Chinensis, Semen Alpiniae Katsumadai, Folium Euryales and the Fructus Sophorae are placed in traditional Chinese medicine drying device, in 55 DEG C of dryings 3.5 hours, take out, are ground into fine powder, for subsequent use;
(2) get the Shishou flesh of fish and be placed in container, add Sucus Zingberis and yellow wine is mixed thoroughly, vexed 20 minutes, take out, slow fire heats, shallow fry until both sides turn golden brown, rubs, for subsequent use; Coagulum Opuntiae sucus is smashed to pieces and is ground into fine powder, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Herba Evolvuli Alsinoides, Rohdea japonica Roth, Lignum Trachycarpi, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in hermetic container, the mass fraction adding 5 times amount is the ethanol of 60%, sealing lixiviate 5 days, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.13, for subsequent use;
(4) joined in above-mentioned clear paste by the crude drug after step (1) and (2) process, stir, high temperature sterilize, encapsulation, to obtain final product.
The instructions of taking of gained thick paste of the present invention agent is: every day three times, each 3-4 spoon, and warm water is taken after mixing with liquid, 7 days courses for the treatment of.
embodiment 4one treats ARR prescription, is prepared from by following bulk drugs, is weight portion (40g/ part): Radix Polygalae 13 parts; Flos Rosae Chinensis 14 parts; Radix fici panduratae 11 parts; Carnis Pseudosciaenae 12 parts; Rhizoma Et Radix Notopterygii 12 parts; Phyllanthus simplex Retz. 12 parts; Coagulum Opuntiae sucus 12 parts; Semen Alpiniae Katsumadai 11 parts; Rohdea japonica Roth 13 parts; Lignum Trachycarpi 11 parts; Radix Lantanae Camaraev 10 parts; 10 parts, Herba Evolvuli Alsinoides; The Radix Paeoniae Alba 13 parts; Folium Euryales 12 parts; The Fructus Sophorae 11 parts.
A kind of preparation method for the treatment of ARR pill is:
(1) the Shishou flesh of fish, Semen Alpiniae Katsumadai, Herba Evolvuli Alsinoides and Flos Rosae Chinensis are placed in stockpot, add cold water and do not have medical material 3-5cm, in cold water, then add the yellow wine of 16% raw material dose, slow fire heating decoction 35 minutes, and filter, filtrate reduced in volume is to 1/3 of original volume, for subsequent use;
(2) get Lignum Trachycarpi, Rohdea japonica Roth, the Radix Paeoniae Alba and Folium Euryales mixing, add 11% raw material dose Sucus Zingberis mix thoroughly, after Sucus Zingberis is sucked, slow fire heats, fried dry, takes out and dries in the air cool, smash to pieces for subsequent use; Get the Fructus Sophorae and Coagulum Opuntiae sucus is cleaned respectively, adding the mass fraction after dilution is 5% refined honey, mixes thoroughly, braised through, puts in parch container, and slow fire is fried to crust light, and tack-free is degree, and taking-up is dried, and smashs into fine powder to pieces, for subsequent use;
(3) getting Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz. and Radix Lantanae Camaraev is placed in medicine pot, add the clear water of 5.5 times amount, slow fire heating decoction twice, first time decocts 24 minutes, second time decocts 15 minutes, merges twice decocting liquid, filters, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.23, for subsequent use;
(4) by the raw material medicated powder after step (1) gained filtrate and step (2) process, join in above-mentioned thick paste, mechanical agitation, add sucrose fine and corn starch, mix homogeneously simultaneously, be processed into the pill of Semen Firmianae size, obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 7-10 ball, and warm water takes, 7 days courses for the treatment of.
Model case: king XX, man, 43 years old, builder., after tired or activity, particularly there is cardiopalmus, uncomfortable in chestly not relax in patient's readme: suffer from arrhythmia and have a surplus for a year, with breathing hard, constipation with dry stool, and the symptoms such as sleep difference.Once took western medicine, symptom after taking medicine obviously alleviates, and recurs after drug withdrawal.After change and take traditional Chinese medicine, medicine time is long, and curative effect is not obvious, is illustrated in come my institute on April 19th, 2013 and check treatment by colleague.Check: Heart Rate 115 times/min, normally, dimly pale tongue, tongue be greasy, rolling pulse in vain for diet and sleep.Electrocardioscopy prompts for: sinus rhythm.
Take the present embodiment gained one and treat ARR pill, instructions of taking: every day three times, each 7-10 ball, warm water takes, 7 days courses for the treatment of.After taking two courses for the treatment of, patient is uncomfortable in chest does not relax, cardio palmus shape obviously reduces, and spirit and muscle power strengthen, and continue two courses for the treatment of of medication, all cards disappear, Electrocardioscopy, recover normal.Pay a return visit after three months, patient body is healthy, without recurrence.
embodiment 5one treats ARR prescription, is prepared from by following bulk drugs, is weight portion (45g/ part): Radix Polygalae 12 parts; Flos Rosae Chinensis 13 parts; Radix fici panduratae 10 parts; Carnis Pseudosciaenae 11 parts; Rhizoma Et Radix Notopterygii 10.5 parts; Phyllanthus simplex Retz. 11.5 parts; Coagulum Opuntiae sucus 11 parts; Semen Alpiniae Katsumadai 9.5 parts; Rohdea japonica Roth 12 parts; Lignum Trachycarpi 10.5 parts; Radix Lantanae Camaraev 9 parts; 9.5 parts, Herba Evolvuli Alsinoides; The Radix Paeoniae Alba 11.5 parts; Folium Euryales 10.5 parts; The Fructus Sophorae 10.5 parts.
A kind of preparation method for the treatment of ARR decoction is:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use; Coagulum Opuntiae sucus is placed in mortar porphyrize powder, for subsequent use;
(2) Phyllanthus simplex Retz., Lignum Trachycarpi, Herba Evolvuli Alsinoides and Folium Euryales mixing, the yellow wine adding 0.6 times of raw material dose is mixed thoroughly, adds a cover vexed 16 minutes, take out, slow fire heat, fry to wine be sucked into degree, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Rohdea japonica Roth, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in medicine pot, add cold water and do not have powder about 4cm, soak 3 hours under room temperature, then the crude drug after step (2) process is added, big fire heated and boiled 12 minutes, turn little fire to decoct 45 minutes, filter, filtrate is for subsequent use;
(4) be placed in stockpot by the Shishou flesh of fish, add the clear water of 3.5 times amount, slow fire boiling 14 minutes, then add clean Chinese rose petal, continue slow fire boiling 12 minutes, filter, filtrate is for subsequent use;
(5) by step (3) and the mixing of (4) gained filtrate, be evaporated to the half of original volume, add the raw material medicated powder after step (1) process, mixing, sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, and each 180-200mL, takes after warm, 7 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Polygalae: base is former: this product is the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.Chemical analysis: root, containing Saponin, can get two kinds of ruscogenin crystallizations, presenegenin A and presenegenin B after hydrolysis.Near again from this plant and belong to senea together root isolate a kind of Saponin Roots of Polygala tenuifolia element, i.e. the 3-β-glycoside of 2 β, 27-dihydroxy-23-carboxyl oleanolic acid.Another containing polygalytol, 2-Acetamido-2-deoxy-D-glucose, alkaloid tenuidine, fatty oil, resin etc.Nature and flavor: bitter, pungent, temperature.Gui Jing: GUIXIN, kidney, lung meridian.Effect: Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm, detumescence.Cure mainly: the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Flos Rosae Chinensis: base is former: be the flower of rosaceous plant Flos Rosae Chinensis.Chemical analysis: flower is containing volatile oil, and its composition is similar to Oleum Rosae Rugosae, and major part is terpene alcohol compound, is mainly Geraniol, nerol, citronellol and glycoside thereof.Another containing gallic acid, quercitrin, tannin, pigment etc.Pharmacological action: Flos Rosae Chinensis has stronger antifungic action.Antibacterial action is had to 17 kinds of funguses when 3% concentration.Having isolated its antibacterial effective ingredient is gallic acid.Nature and flavor: sweet; Temperature; Nontoxic.Gui Jing: liver; Kidney channel.Function cures mainly: promoting blood flow to regulate menstruation; Removing toxic substances and promoting subsidence of swelling.Main menoxenia; Dysmenorrhea; Amenorrhea; Traumatic injury; Swelling and pain due to blood stasis; Scrofula; Carbuncle; Scald.
Radix fici panduratae: base is former: be root, the leaf of moraceae plants Radix fici panduratae.Nature and flavor: sweet in the mouth, micro-pungent, property are put down.Function cures mainly: expelling wind and removing dampness; Removing toxic substances and promoting subsidence of swelling; Promoting blood circulation to restore menstrual flow.Main air pain of dampness syndrome; Yellow cellulitis; Malaria; Pertussis; Galactostasis; Acute mastitis; Dysmenorrhea; Amenorrhea; Carbuncle furuncle and phyma pain; Traumatic injury; Venom.
Carnis Pseudosciaenae: base is former: be the meat of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Chemical analysis: edible part is containing protein, fatty, ash, calcium, phosphorus, ferrum, thiamine (thiamine), riboflavin (riboflavin), nicotinic acid (nicotinicacid), iodine etc.Nature and flavor: sweet in the mouth; Property is put down.Gui Jing: spleen; Stomach; Liver; Kidney channel.Function cures mainly: replenishing QI to invigorate the spleen; The kidney invigorating; Improving eyesight; Dysentery relieving.Main after being ill, puerperal asthenia; Hypogalactia; Lumbago due to renal deficiency; Edema; Blurring of vision; Headache; Stomachache; Dysentery.
Rhizoma Et Radix Notopterygii: base is former: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.Chemical analysis: Radix et Rhizoma Notopterygii is containing volatilization wet goods.Nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Effect: cold expelling, dispels the wind, dehumidifying, pain relieving.Cure mainly: for anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Phyllanthus simplex Retz.: base is former: be herb or the root of euphorbia plant Phyllanthus simplex Retz..Nature and flavor: 1. " Nanning City's medicine will ": " sweetness and bitterness." 2. " Guangxi Chinese medicinal herbal ": " sweet, flat." function cures mainly: 1. " Nanning City's medicine will ": " herb: help digestion, nebula removing.Control infantile malnutrition and infantile malnutrition is pleasing to the eye." 2. " register planted by Guangxi medicine ": " herb: tonifying the spleen and stomach, controls gonorrhea, and bone is choked larynx, infantile malnutrition.Root: control galactapostema.”
Coagulum Opuntiae sucus: base is former: be the juice concretion flowed out in the fleshy stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.Nature and flavor: sweet; Cold in nature.Function cures mainly: clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Main hemorrhoidal bleeding; Have blood in stool; Furuncle swells; Scald; Palpitation with a distress feeling; Acute infantile convulsion wind.
Semen Alpiniae Katsumadai: base is former: be the seed group of greedy section plant plait Fructus Amomi Rotundus.Chemical analysis: seed is containing Alpinetin, cardamonin.Nature and flavor: pungent, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: warming middle-JIAO dampness; Circulation of qi promoting spleen invigorating.The coldness and pain in the epigastrium of the cloudy stagnant taste of main cold-damp; Feeling of fullness is done swollen, vomiting; Have loose bowels; Food indigested food; Expectorant Yu; Foot gas; Explain malaria; Halitosis.
Rohdea japonica Roth: base is former: be Liliaceae Rohdea plant Rohdea japonica Roth, with root stock or all herbal medicine.Chemical analysis: leaf and root stock contain Cardiac glycosides: Rhodexin A, second, third and Saponin.Rhodexin A is the rhamnoside of hispidagenin, and rhodexin second is the rhamnoside of folinerigenin, and rhodexin third is folinerigenin-rhamnose-glycoside.According near, leaf contains rhodexin fourth and cupreol glycoside.Fresh leaf and root stock contain Rhodexin A about 0.008%, rhodexin third about 0.03%.Cured leaf contains thick general glycoside about 0.43%, rhodexin fourth about 0.1%.Pharmacological action: 1, rhodexin strengthens the contractility of cardiac muscle, and the conduction of energy excited vagus and suppression cardiac muscle, make decreased heart rate, and have diuresis.2, Rohdea japonica Roth weak solution only makes intestinal vasoconstriction, then makes it expansion to coronary vasodilator, renal blood vessels, cerebrovascular and limb vessel etc.; Denseer solution, because directly acting on blood vessel wall, can make various tissue, the blood vessel of organ all shrinks.3, there is excitation to gastrointestinal and uterine smooth muscle, can be strengthened it and shrink.4, toxicity test: intravenous injection minimum lethal dose, cat per kilogram of body weight is 0.091 milligram, and rabbit per kilogram is 0.29 milligram, and the minimum lethal dose with 1/3 is injected in the subcutaneous of cat, in 6 hours, hyperemesis occurs, and has larger cumulative action.5, bacteriostatic test: tincture tube dilution method, 1:512 is to diphtheria corynebacterium, and 1:128 all has inhibitory action to staphylococcus aureus, group B streptococcus and bacillus subtilis etc.6, the effect of this product acetum is weaker than tincture, and decoct is invalid.Nature and flavor: bitter, sweet, cold.Slightly poisonous.Gui Jing: lung; Heart channel.Function cures mainly: heat-clearing and toxic substances removing, heart tonifying diuresis.For preventing and treating diphtheria, the myocarditis that diphtheria causes, laryngopharynx swelling and pain, lyssodexis, bacillary dysentery, Cardiac Failure From Rheumatic Heart Disease; Traumatic injury is controlled in external, venom, burn and scald, mastitis, carbuncle furuncle and phyma poison.
Lignum Trachycarpi: base is former: be the heartwood of babassu Petiolus Trachycarpi.Nature and flavor: bitter in the mouth; Puckery; Property is put down.Gui Jing: the heart; Spleen channel.Function cures mainly: tranquilizing by nourishing the heart; Astringing to arrest bleeding.Main cardiopalmus; Dizzy; Metrorrhagia; Proctoptosis; Uterine prolapse.
Radix Lantanae Camaraev: base is former: be the root of Verbenaceae lantana.Chemical analysis: root is containing stachyose, verbascose, ajugose, verbascotetraose, lantanoseA, B, theveside, theviridoside, all square rafter glycosides, 8-shows Semen Strychni glycoside, shanzhiside methyl ester, lantanolic acid, 22 β-O-Radix Angelicae Sinensis acyl oleanolic acid, 22 beta-hydroxy oleanolic acid, 19a-Hydroxyursolic Acid, its ursolic acid Radix Achyranthis Bidentatae leaf lantana diketone of Lantaiursolic acid i.e. 3 β-isovaleryl-19 α-hydroxyl, different Radix Achyranthis Bidentatae leaf lantana diketone, 6-methoxyl group Radix Achyranthis Bidentatae leaf lantana diketone, 7-methoxyl group Radix Achyranthis Bidentatae leaf lantana diketone, 6-methoxyl group different Radix Achyranthis Bidentatae leaf horse tassel stolen goods diketone, 7-methoxyl group different Radix Achyranthis Bidentatae leaf lantana diketone etc.Pharmacological action: 1. antiinflammatory action gavage gives Radix Lantanae Camaraev water drug-decocting concentrating liquid 20g/(kgd), 40g/(kgd), continuous 3-6d, can show the rat paw edema percentage rate suppressed caused by Ovum Gallus domesticus album; Show and reduce the mouse peritoneal capillary permeability that acetic acid causes and to increase, in obvious antiinflammatory action.2. analgesic activity gavage gives the water drug-decocting concentrating liquid of above-mentioned dosage, shows minimizing acetic acid induced mice writhing response number of times; Extend the thermostimulation induced mice pain sensation response latency, in certain analgesic activity.3. immunization gavage gives the water drug-decocting concentrating liquid of above-mentioned dosage, continuous 5d, can dramatically the Thymus and spleen weight increasing young mice, and prompting Radix Lantanae Camaraev may have enhancing immunity function.Toxicity: have mild toxicity to mice.Nature and flavor: bitter in the mouth; Cold in nature.Gui Jing: bladder; Liver; Kidney channel.Function cures mainly: clearing away heat-fire; Detoxicating and resolving stagnation of pathogens.Main cold, fever, summer-heat headache; Toothache due to stomach-fire; Pharyngolaryngitis; Mumps; Rheumatic arthralgia; Scrofula sucutaneous nodule.
Herba Evolvuli Alsinoides: base is former: be the herb of dicotyledon scammonia section plant Herba Evolvuli Alsinoides.Chemical analysis: herb is containing flavonoid glycoside, polyphenolic acid, saccharide, pentatriacontane, and melissane, cupreol, betanin and a kind of fusing point are the water-soluble alkali of 60-61 DEG C.Pharmacological action: water-soluble alkali low dose (0.02mg) can weaken the contractility of the frog heart in place, decreased heart rate; Heavy dose of (0.1mg) then makes it be stopped at relaxing period.When 1:500000-250000 concentration, the shrinkage amplitude of isolated rabbit small intestinal can be reduced, increase its tension force.Nature and flavor: sweetness and bitterness; Cool.Gui Jing: liver; Spleen; Kidney channel.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances.Main jaundice; Dysentery; Stranguria with turbid discharge; Leukorrhagia; Treat swollen; Scabies.
The Radix Paeoniae Alba: base is former: this product is the dry root of ranunculaceae plant Radix Paeoniae.Chemical analysis: root contains paeoniflorin, paeonol, paeoniflorin, benzoic acid about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.Nature and flavor: bitter, sour, are slightly cold.Gui Jing: return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Cure mainly: dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Folium Euryales: base is former: be the leaf of nymphaeaceae plant Gorgon euryale.Nature and flavor: bitter; Pungent; Flat.Gui Jing: liver; Kidney channel.Function cures mainly: promoting flow of QI and blood; Hemostasis by removing blood stasis.Main haematemesis; Have blood in stool; Women's retention of placenta in puerperal.
The Fructus Sophorae: base is former: be the fruit of leguminous plant Chinese scholartree.Chemical analysis: containing 9 flavonoids and isoflavonoid, wherein have genistein, sophoricoside, genistein-4'-glucosidorhamnoside., nimbecetin glucoside-C, sophoraflavonoloside and globulariacitrin, globulariacitrin content very high, reach 46% in young fruit.Sophoricoside content is 1.5-2.0%. sophoraflavonoloside content is 0.8%.Another containing sophorose 0.4%.Seed oil-containing 9.9%.In the fatty acid dissociated or combine, oleic acid is 22.3%, and linoleic acid is 53%, and linolenic acid is 12%.Pharmacological action: 1. antifertility action: the Fructus Sophorae glycoside, genistein and the nimbecetin that contain in the Fructus Sophorae have antifertility action and estrogen activity to mice.2. other effect: this product is containing a large amount of rutin.Rutin tool antiinflammatory action and the effect of Citrin sample.There is maintenance VAR, reduce its permeability, reduce the effect such as fragility, the liver of fatty infiltration is dispelled fat effect.Also has the effect of antiviral and suppression aldose reductase.Bisflavone glycoside contained by this product has the effect that the protection stronger compared with rutin refers to matter peroxidase and antioxidant enzyme.Nature and flavor: bitter, cold.Gui Jing: enter liver, large intestine channel.Function cures mainly: heat clearing away, profit liver, removing heat from blood, hemostasis.Control hemorrhoidal hamorrhage and rush down blood, hemorrhoidal bleeding, metrorrhagia, stranguria with blood, dysentery, ambition is unhappy, dizziness due to wind pathogen for falling, erosion of vulva pruritus due to damp pathogen.
test example 1gained one of the present invention treats the clinical practice of ARR prescription (embodiment 5):
1, data and method
1.1 physical data
Screen 330 routine arrhythmia patients in June ,-2013 in July, 2009 in four hospitals, all patients all belong to voluntary participation.Wherein male 192 example, women 138 example, the age 43-69 year, 53.5 ± 4.5 years old mean age, the course of disease is at 1-7.All patients are divided into experimental group and matched group at random, experimental group 220 example, matched group 110 example.The clinical data such as age, sex, the course of disease of two groups of patients is through comparing, and no significant difference (P > 0.05), has comparability.
1.2 Therapeutic Method
Experimental group takes products obtained therefrom of the present invention, instructions of taking: twice daily, and each 180-200mL, takes after warm, 7 days courses for the treatment of.Observe four courses for the treatment of of treatment altogether.Matched group takes other medicine (as propafenone, quinidine, the conventional medication such as lignocaine).
1.3 curative effect determinate standard
Cure: clinical symptoms all disappears, lab testing is normal, and electrocardiogram recovers normal.
Effective: clinical symptoms obviously alleviates, lab testing obviously improves, and electrocardiogram takes a turn for the better.
Effective: clinical symptoms alleviates to some extent, lab testing makes moderate progress, and electrocardiogram takes a turn for the better.
Invalid: clinical symptoms has no and alleviates or aggravation.
Total effective rate=(cure number of cases+effective number of cases+effectively number of cases) ∕ total inspection case load × 100%.
1.4 therapeutic outcome
Two groups of therapeutic outcomes are as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group compares
Therapeutic effect: experimental group cures 160 examples (72.7%), effective 41 examples (18.6%), effective 16 examples (7.3%), invalid 3 examples (1.4%), total effective rate is 98.6%.From result, experimental group therapeutic effect is obviously better than matched group.
The present invention select Radix Polygalae, Flos Rosae Chinensis, Radix fici panduratae, Carnis Pseudosciaenae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Coagulum Opuntiae sucus, Semen Alpiniae Katsumadai, Rohdea japonica Roth, Lignum Trachycarpi and Radix Lantanae Camaraev etc. totally 15 taste primary raw material medicines be prepared from.Fang Zhong, Radix Polygalae has Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, effect of detumescence; Flos Rosae Chinensis promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling; Radix fici panduratae expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling; Carnis Pseudosciaenae replenishing QI to invigorate the spleen, the kidney invigorating, improving eyesight; Rhizoma Et Radix Notopterygii cold expelling, dispels the wind, dehumidifying, pain relieving; Coagulum Opuntiae sucus clearing away heat and cooling blood, tranquilizing by nourishing the heart; Rhodexin contained by Rohdea japonica Roth strengthens the contractility of cardiac muscle, and the conduction of energy excited vagus and suppression cardiac muscle, make decreased heart rate, and have diuresis; Lignum Trachycarpi tranquilizing by nourishing the heart; Radix Lantanae Camaraev clearing away heat-fire, detoxicating and resolving stagnation of pathogens; The pain relieving of Radix Paeoniae Alba suppressing the hyperactive liver, astringing YIN to stop sweating.All medicines share, and play unimpeded heart arteries and veins altogether, the convergence motive, tranquillizing and allaying excitement, effect of disperse blood stasis and dredge collateral.After treating four courses for the treatment of, experimental group total effective rate can reach 98.6%, and matched group is only 77.3%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat an ARR prescription, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Polygalae 9-16; Flos Rosae Chinensis 11-15; Radix fici panduratae 8-12; Carnis Pseudosciaenae 9-13; Rhizoma Et Radix Notopterygii 7-14; Phyllanthus simplex Retz. 10-13; Coagulum Opuntiae sucus 8-14; Semen Alpiniae Katsumadai 6-13; Rohdea japonica Roth 10-14; Lignum Trachycarpi 9-12; Radix Lantanae Camaraev 6-12; Herba Evolvuli Alsinoides 7-13; Radix Paeoniae Alba 9-14; Folium Euryales 6-15; Fructus Sophorae 8-13.
2. one as claimed in claim 1 treats ARR prescription, it is characterized in that, is prepared from by following bulk drugs, be weight portion: Radix Polygalae 11-13; Flos Rosae Chinensis 12-14; Radix fici panduratae 9-11; Carnis Pseudosciaenae 10-12; Rhizoma Et Radix Notopterygii 9-12; Phyllanthus simplex Retz. 11-12; Coagulum Opuntiae sucus 10-12; Semen Alpiniae Katsumadai 8-11; Rohdea japonica Roth 11-13; Lignum Trachycarpi 10-11; Radix Lantanae Camaraev 8-10; Herba Evolvuli Alsinoides 9-10; Radix Paeoniae Alba 10-13; Folium Euryales 9-12; Fructus Sophorae 10-11.
3. one as claimed in claim 1 treats ARR prescription, it is characterized in that, is prepared from by following bulk drugs, be weight portion: Radix Polygalae 12; Flos Rosae Chinensis 13; Radix fici panduratae 10; Carnis Pseudosciaenae 11; Rhizoma Et Radix Notopterygii 10.5; Phyllanthus simplex Retz. 11.5; Coagulum Opuntiae sucus 11; Semen Alpiniae Katsumadai 9.5; Rohdea japonica Roth 12; Lignum Trachycarpi 10.5; Radix Lantanae Camaraev 9; Herba Evolvuli Alsinoides 9.5; The Radix Paeoniae Alba 11.5; Folium Euryales 10.5; The Fructus Sophorae 10.5.
4. the one as described in claim 1-3 treats ARR prescription, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use; Coagulum Opuntiae sucus is placed in mortar porphyrize powder, for subsequent use;
(2) Phyllanthus simplex Retz., Lignum Trachycarpi, Herba Evolvuli Alsinoides and Folium Euryales mixing, add yellow wine and mix thoroughly, add a cover vexed 12-20 minute (preferably adding a cover vexed 16 minutes), take out, slow fire heat, fry to wine be sucked into degree, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Rohdea japonica Roth, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in medicine pot, add cold water and do not have powder about 4cm, soak under room temperature 2-4 hour (soaking 3 hours under being preferable over room temperature), then the crude drug after step (2) process is added, big fire heated and boiled, turn little fire to decoct 35-55 minute (preferably turning little fire to decoct 45 minutes), filter, filtrate is for subsequent use;
(4) the Shishou flesh of fish is placed in stockpot, add the clear water (preferably adding the clear water of 3.5 times amount) of 2.5-4.5 times amount, slow fire boiling 10-18 minute (preferred slow fire boiling 14 minutes), then clean Chinese rose petal is added, continue slow fire boiling 8-16 minute (preferred slow fire boiling 12 minutes), filter, filtrate is for subsequent use;
(5) by step (3) and the mixing of (4) gained filtrate, be evaporated to the half of original volume, add the raw material medicated powder after step (1) process, mixing, sterilizing encapsulates, and to obtain final product.
5. a kind of preparation method for the treatment of ARR decoction according to claim 4, it is characterized in that, in step (2), the amount of yellow wine is the 0.45-0.75 of raw material dose doubly (amount of preferred yellow wine is 0.55-0.65 times of raw material dose, and the amount of the yellow wine be more preferably is 0.6 times of raw material dose).
6. a kind of preparation method for the treatment of ARR decoction according to claim 4, it is characterized in that, in step (3), the time of big fire heated and boiled is 7-17 minute (time of preferred big fire heated and boiled is 10-14 minute, and the time of the big fire heated and boiled be more preferably is 12 minutes).
7. the one as described in claim 1-3 treats ARR prescription, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) Fructus Sophorae is cleaned, and intense fire is fried to surface coke black, inner buff, and taking-up cools, porphyrize powder, for subsequent use; Semen Alpiniae Katsumadai slow fire heats, and fries to micro-yellow and has fragrance to overflow as degree, taking out and dry in the air cool, smash into fine powder to pieces, for subsequent use;
(2) Flos Rosae Chinensis and Folium Euryales mixing, add the Mel after dilution, slow fire fried dry, take out, grind to the powder, for subsequent use; The Shishou flesh of fish is put on smokeless intense fire, ashing, and palpus sustainability, together smashs to pieces with Coagulum Opuntiae sucus, and be ground into fine powder, for subsequent use;
(3) by the raw material powder mixing after step (1) and (2) process, sieve, obtain mixed powder, for subsequent use;
(4) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Rohdea japonica Roth, Lignum Trachycarpi, Radix Lantanae Camaraev, Herba Evolvuli Alsinoides grass and the Radix Paeoniae Alba are placed in Chinese medicament extracting device, take the concentration of 4-7 times of raw material dose as the ethanol of 55% be solvent (be preferably the ethanol of 55% with the concentration of 5.5 times of raw material doses be solvent), heating and refluxing extraction 40-70 minute (preferred heating and refluxing extraction 55 minutes), filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.22-1.25, for subsequent use;
(5) step (3) gained mixed powder is joined in above-mentioned thick paste, mechanical agitation, add simultaneously mass fraction be 10% lactose fine powder, mass fraction be 7.5% microcrystalline Cellulose and mass fraction be the magnesium trisilicate of 4.5%, mix homogeneously, granulate, granulate, dry, incapsulate shell, to obtain final product.
8. a kind of preparation method for the treatment of ARR capsule according to claim 7, is characterized in that, the middle 85-135 mesh sieve excessively of step (3) (preferred 95-125 mesh sieve excessively, mistake 110 mesh sieve be more preferably).
9. the one as described in claim 1-3 treats ARR prescription, it is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:
(1) Flos Rosae Chinensis, Semen Alpiniae Katsumadai, Folium Euryales and the Fructus Sophorae are placed in traditional Chinese medicine drying device, in 50-60 DEG C of dry 2-5 hour (being preferable over 55 DEG C of dryings 3.5 hours), taking out, are ground into fine powder, for subsequent use;
(2) get the Shishou flesh of fish and be placed in container, add Sucus Zingberis and yellow wine is mixed thoroughly, vexed 15-25 minute (preferably vexed 20 minutes), take out, slow fire heats, shallow fry until both sides turn golden brown, rubs, for subsequent use; Coagulum Opuntiae sucus is smashed to pieces and is ground into fine powder, for subsequent use;
(3) Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz., Herba Evolvuli Alsinoides, Rohdea japonica Roth, Lignum Trachycarpi, Radix Lantanae Camaraev and the Radix Paeoniae Alba are placed in hermetic container, the mass fraction adding 4-6 times amount is the ethanol of 60% (mass fraction preferably adding 5 times amount is the ethanol of 60%), sealing lixiviate 3-7 days (preferably sealing lixiviate 5 days), filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.12-1.15, for subsequent use;
(4) joined in above-mentioned clear paste by the crude drug after step (1) and (2) process, stir, high temperature sterilize, encapsulation, to obtain final product.
10. the one as described in claim 1-3 treats ARR prescription, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) the Shishou flesh of fish, Semen Alpiniae Katsumadai, Herba Evolvuli Alsinoides and Flos Rosae Chinensis are placed in stockpot, add cold water and do not have medical material 3-5cm, then in cold water, add the yellow wine (preferably adding the yellow wine of 16% raw material dose) of 12%-20% raw material dose, slow fire heating decocts 25-45 minute (preferred slow fire heating decoction 35 minutes), filter, filtrate reduced in volume is to 1/3 of original volume, for subsequent use;
(2) get Lignum Trachycarpi, Rohdea japonica Roth, the Radix Paeoniae Alba and Folium Euryales mixing, add 11% raw material dose Sucus Zingberis mix thoroughly, after Sucus Zingberis is sucked, slow fire heats, fried dry, takes out and dries in the air cool, smash to pieces for subsequent use; Get the Fructus Sophorae and Coagulum Opuntiae sucus is cleaned respectively, adding the mass fraction after dilution is 5% refined honey, mixes thoroughly, braised through, puts in parch container, and slow fire is fried to crust light, and tack-free is degree, and taking-up is dried, and smashs into fine powder to pieces, for subsequent use;
(3) getting Radix Polygalae, Radix fici panduratae, Rhizoma Et Radix Notopterygii, Phyllanthus simplex Retz. and Radix Lantanae Camaraev is placed in medicine pot, add the clear water (preferably adding the clear water of 5.5 times amount) of 4-7 times amount, slow fire heating decoction twice, first time decocts 18-30 minute (preferably first time decocts 24 minutes), second time decocts 10-20 minute (preferably second time decocts 15 minutes), merges twice decocting liquid, filters, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.20-1.25, for subsequent use;
(4) by the raw material medicated powder after step (1) gained filtrate and step (2) process, join in above-mentioned thick paste, mechanical agitation, add sucrose fine and corn starch, mix homogeneously simultaneously, be processed into the pill of Semen Firmianae size, obtain final product.
CN201510537979.0A 2015-08-28 2015-08-28 Prescription for treating arrhythmia Pending CN105056074A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789863A (en) * 1993-09-24 1995-04-04 Morishita Roussel Kk Isolation refining method for ginsenoside re and antiarhythmic agent mainly composed of compound
CN103705733A (en) * 2014-01-17 2014-04-09 刘镜 Chinese medicine capsule for treating arrhythmia and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789863A (en) * 1993-09-24 1995-04-04 Morishita Roussel Kk Isolation refining method for ginsenoside re and antiarhythmic agent mainly composed of compound
CN103705733A (en) * 2014-01-17 2014-04-09 刘镜 Chinese medicine capsule for treating arrhythmia and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
孙继红: "中药复律汤治心律不齐45例", 《陕西中医》 *

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