CN105056011A - Chinese medicine preparation for treating arrhythmia and preparation method - Google Patents
Chinese medicine preparation for treating arrhythmia and preparation method Download PDFInfo
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Abstract
The invention discloses a Chinese medicine preparation for treating arrhythmia. The Chinese medicine preparation for treating the arrhythmia is prepared from, by weight, 12-20 parts of ginseng, 10-15 parts of choerospondias axillaries, 8-13 parts of anthriscus sylvestris, 9-15 parts of ajuga decumbens thumb, 11-14 parts of fructus hordei germinatus, 7-15 parts of amber, 9-13 parts of radix ceratostigmae, 6-14 parts of callicarpa longissima, 10-15 parts of wahlenbergia marginata, 8-15 parts of clerodendron cyrtophyllum turcz, 7-14 parts of rhizoma acori graminei, 9-12 parts of crocus sativus, 7-13 parts of cynanchum amplexicaule, 10-13 parts of red rhodobryum and 11-17 parts of angelica sinensis. The Chinese medicine preparation is prepared from Chinese medicine materials and is high in safety, wide in applicability and free of obvious toxic and side effects; the formula of the preparation completely confirms with the Chinese medicine principle and has the effects of strengthening the middle warmer, benefiting qi, nourishing the heart, calming the mind and the like; the preparation is low in cost, good in treatment effect, little in adverse reaction and easy to accept by patients.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat ARR Chinese medicine preparation and method for making.
Background technology
Arrhythmia is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node; exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Arrhythmia is one group of disease important in cardiovascular disease.It can be fallen ill separately and also can occur together with cardiovascular diseases.Can break out and cause sudden death, also sustainablely involving heart and exhaustion.Slight arrhythmia is without obvious clinical manifestation, and heavier arrhythmia can cause cardiopalmus, uncomfortable in chest, dizzy, hypotension, perspiration, and fainting appears in severe patient, Adams Stokes syndrome, even dies suddenly.Clinical manifestation is different because types of arrhythmia is different.Drug therapy is ARR primary treatments.By the application of general medicine based on oral.The rule of clinical application is that selection is with strong points according to ARR mechanism, and curative effect is the little medicine of untoward reaction obviously.
Publication No. CN104644846A(application number 201310575732.9) Chinese patent literature disclose one and be used for the treatment of ARR Chinese medicine, Chinese medicinal components is Fructus Ligustri Lucidi 30 ~ 45 grams, Arillus Longan 5 ~ 10 grams, Semen Ziziphi Spinosae 12 ~ 16 grams, 8 ~ 12 grams, Colla Corii Asini, Radix Polygalae 15 ~ 20 grams, Radix Sophorae Flavescentis 30 ~ 40 grams, root of subprostrate sophora 18 ~ 25 grams, Ramulus Uncariae Cum Uncis 15 ~ 18 grams, Aconitum carmichjaelii Debx. 9 ~ 15 grams.。Publication No. CN104173915A(application number 201410356112.0) Chinese patent literature disclose one and treat ARR Chinese medicine composition, comprise Radix Sophorae Flavescentis, Dens Draconis, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Radix Ilicis Pubescentis, Cinnabaris, Fructus Aurantii, Rhizoma Curcumae, Radix Astragali, Radix Scutellariae, Cortex Magnoliae Officinalis, Pollen Typhae, Rhizoma Ligustici, Herba Taraxaci, Radix Aconiti Lateralis Preparata, Flos Citri Sarcodactylis, Bulbus Allii Macrostemonis, Folium Isatidis, Radix Polygalae, Oletum Trogopterori, Semen Cuscutae, Radix Curcumae, Poria, Fructus Aurantii Immaturus, Poria cum Radix Pini, Lignum Santali Albi, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Fructus Hordei Germinatus, Rhizoma Sparganii.Publication No. CN103961677A(application number 201410233369.7) Chinese patent literature disclose one and treat ARR Traditional Chinese drug mixture, medical material comprises Cortex Cinnamomi 30 parts, Ramulus Cinnamomi 12 parts, Concha Ostreae 30 parts, Radix Paeoniae Rubra 10 parts, the Radix Astragali 30 parts, 20 parts, Fructus Jujubae, Os Draconis 30 parts, 6 parts, Rhizoma Zingiberis Recens, Radix Aconiti Lateralis Preparata 15 parts, 6 parts, Radix Glycyrrhizae, 20 parts, Poria, Rhizoma Pinelliae 18 parts.
Western medicine arrhythmia does not destroy arrhythogenic pathological tissue; diseased region myocardium cellular electrophysiologicalsensor performance such as conduction velocity and (or) refractory stage length is only made to change to some extent; long-term taking all has adverse side effect in various degree; serious caused ventricular arrhythmia or heart block and fatal; comparatively speaking; Chinese traditional treatment safety and stability; side effect is less; traditional Chinese medical science formula at present about this disease for the treatment of also has many; but curative effect difference is larger; thus, needs are had to work out the reliable traditional Chinese medical science formula of a kind of determined curative effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of stable curative effect, the ARR Chinese medicine preparation for the treatment of that can take for a long time and method for making.
Technical scheme of the present invention is:
Treat ARR Chinese medicine preparation, be prepared from primarily of following bulk drugs, be weight portion: Radix Ginseng 12-20, Fructus Choerospondiatis 10-15, Radix anthrisci 8-13, Herba Ajugae 9-15, Fructus Hordei Germinatus 11-14, succinum 7-15, Radix ceratostigmatis willemottiani 9-13, Caulis te Folium Callicarpae Longissimae 6-14, Herba Wahlenbergiae 10-15, Radix Clerodenri Cyrtophylli 8-15, Rhizoma Acori Graminei 7-14, Stigma Croci 9-12, Radix Cynanchi Amplexicaulis 7-13, Rhodobryum roseum Limpr. 10-13, Radix Angelicae Sinensis 11-17.
In preferred scheme, Radix Ginseng 14-18, Fructus Choerospondiatis 11-14, Radix anthrisci 9-12, Herba Ajugae 10-14, Fructus Hordei Germinatus 12-13, succinum 9-13, Radix ceratostigmatis willemottiani 10-12, Caulis te Folium Callicarpae Longissimae 8-12, Herba Wahlenbergiae 11-14, Radix Clerodenri Cyrtophylli 10-13, Rhizoma Acori Graminei 9-12, Stigma Croci 10-11, Radix Cynanchi Amplexicaulis 9-11, Rhodobryum roseum Limpr. 11-12, Radix Angelicae Sinensis 13-15.
Be more preferably, Radix Ginseng 16, Fructus Choerospondiatis 12.5, Radix anthrisci 10.5, Herba Ajugae 12, Fructus Hordei Germinatus 12.5, succinum 11, Radix ceratostigmatis willemottiani 11, Caulis te Folium Callicarpae Longissimae 10, Herba Wahlenbergiae 12.5, Radix Clerodenri Cyrtophylli 11.5, Rhizoma Acori Graminei 10.5, Stigma Croci 10.5, Radix Cynanchi Amplexicaulis 10, Rhodobryum roseum Limpr. 11.5, Radix Angelicae Sinensis 14.
The ARR Chinese medicine preparation of described treatment, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, add decocting in water together with step (3) made crude drug, big fire boils 20-30 minute, and (preferred, 22-28 minute is boiled in big fire; Be more preferably, big fire boils 25 minutes), filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, obtain powder.
The preparation method of the ARR Chinese medicine preparation powder of described treatment, step (4) three amount of water are the 6-8 of boiled crude drug quality doubly (preferred, amount of water is 7 times of boiled crude drug quality).
The ARR Chinese medicine preparation of described treatment, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, amount of water is 7 times of boiled crude drug quality, 20-30 minute is boiled in big fire, filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, make medicated powder, add starch, dried starch mixing, add 10% starch slurry mixing soft material processed, cross 16 mesh sieves to granulate, 60 DEG C of dryings, cross 12 mesh sieve granulate, add lubricant, tabletting, obtains tablet.
The preparation method of the ARR Chinese medicine preparation tablet of described treatment, step (4) big fire is boiled 22-28 minute (preferred, big fire boils 25 minutes).
The ARR Chinese medicine preparation of described treatment, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, get Testa Tritici to be sprinkled in hot pot, be heated to smolder, add each raw material tablet and mix thoroughly, and cover one deck Testa Tritici on raw material tablet, little fire is vexed to be taken out to crude drug is surperficial in time yellow, and sieve removes Testa Tritici, dries in the air cool;
(3) get Radix Ginseng and Rhodobryum roseum Limpr. sucrose solution on the rocks boils, the amount of crystal sugar water is 5 times of crude drug quality, boils when reducing by half to water, filters, collect filtrate;
(4) by Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (2) made crude drug, amount of water is 7.5 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 25-37 minute, filter, collect filtrate, operation twice, merges twice gained filtrate;
(5) made to step (3) (4) filtrate merged, then add step (1) made medicamental pulverata, mixing, obtains decoction.
The preparation method of the ARR Chinese medicine preparation decoction of described treatment, step (4) big fire is boiled rear little fire and is decocted 28-34 minute (preferred, big fire is boiled rear little fire and decocted 31 minutes).
The ARR Chinese medicine preparation of described treatment, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, amount of water is 7 times of boiled crude drug quality, big fire boils 20-30 minute, and (preferred, 22-28 minute is boiled in big fire; Be more preferably, big fire boils 25 minutes), filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, make medicated powder, add water and generally make ball, obtain pill.
The preparation method of the ARR Chinese medicine preparation pill of described treatment, step (5) was pulverized 100-160 mesh sieve and (preferably, was pulverized 120-140 mesh sieve; Be more preferably, pulverized 130 mesh sieves).
The ARR Chinese medicine preparation scientific formula for the treatment of provided by the invention, can be prepared into multiple dosage form and be easy to carry, conveniently take.In addition, excellent results of the present invention also shows:
1, the present invention is made up of Chinese medicine material, and safety is high, and the suitability is wide, without obvious toxic-side effects;
2, this prescription meets Chinese medicine principle completely, has the effect such as invigorating the spleen and replenishing QI, tranquilizing by nourishing the heart;
3, cost of the present invention is low, good effect, and untoward reaction is few, and patient easily accepts.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Ginseng: base is former: be the root of Araliaceae Radix Ginseng.Nature and flavor: sweet, micro-hardship, tepor.Gui Jing: return spleen, lung, heart channel.Function cures mainly: QI invigorating, Gu de-, promote the production of body fluid, calms the nerves, Fructus Alpiniae Oxyphyllae.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.
Fructus Choerospondiatis: base is former: be fresh fruit or the pit of Anacardiaceae plant Fructus Choerospondiatis.Nature and flavor: sour and astringent are cool.Function cures mainly: removing toxic substances, convergence, pain relieving, hemostasis.For burn and scald, traumatic hemorrhage, psoriasis.
Radix anthrisci: base is former: be the root of samphire Radix anthrisci.Nature and flavor: slightly warm in nature, sweet in the mouth is pungent.Gui Jing: enter spleen, stomach, lung three warp.Function cures mainly: invigorating the spleen and replenishing QI.Control insufficiency of the spleen flatulence due to improper diet, limbs fatigue, cough and asthma due to lung deficiency, old man's nocturia, and consumer edema.
Herba Ajugae: base is former: be the Herb of labiate Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.).Nature and flavor: bitter sweet, cold.Gui Jing: enter lung meridian.Function cures mainly: relieving cough and resolving phlegm, heat clearing away, removing heat from blood, detumescence, removing toxic substances.Control tracheitis, spit blood, epistaxis, bloody dysentery, gonorrhea, laryngopharynx swelling and pain, furuncle, carbuncle, traumatic injury.
Fructus Hordei Germinatus: base is former: be the Fructus Hordei Vulgaris caryopsis germinateed.Nature and flavor: sweet, tepor.Gui Jing: enter spleen, stomach warp.Function cures mainly: help digestion, and in, the therapeutic method to keep the adverse QI flowing downwards.Control food stagnation not disappear, distension and fullness in the abdomen, inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.
Succinum: base is former: be the Hydrocarbon of prolonged condensation under the resin burial ground of pinaceae plant in ancient times.Nature and flavor: sweet are flat.Gui Jing: enter the heart, liver, small intestine meridian.Function cures mainly: tranquillizing the mind by relieving convulsion, and dissipating blood stasis stops blooding, relieving stranguria by diuresis.Control infantile convulsion epilepsy, palpitation with fear insomnia, stranguria with blood hematuria, urinary obstruction, women's amenorrhea, stop the stasis of blood stomachache puerperal, skin sore, traumatic injuries.
Radix ceratostigmatis willemottiani: base is former: be the root of Plumbaginaceae plant Radix ceratostigmatis willemottiani.Nature and flavor: warm in nature, sweet in the mouth.Function cures mainly: promoting blood circulation and stopping pain, blood stasis dispersing and fresh blood promoting.
Caulis te Folium Callicarpae Longissimae: base is former: be the leaf of Verbenaceae Caulis te Folium Callicarpae Longissimae.Nature and flavor: pungent, temperature.Function cures mainly: expelling wind and cold, sterilization of invigorating blood circulation.Dispelling the wind and dampness pathogens osteodynia, cough due to wind and cold, abdominal pain due to accumulation of cold, innominate toxic swelling, traumatic injury.
Herba Wahlenbergiae: base is former: be root or the whole herb with root of Campanulaceae Herba Wahlenbergiae.Nature and flavor: property is put down, sweet and slightly bitter taste.Gui Jing: enter spleen, the heart.Function cures mainly: tonify deficiency, induces sweat.Control deficient impairment caused by overstrain, hemoptysis, epistaxis, spontaneous perspiration, night sweat, women leucorrhea, the cough due to common cold, stomachache, dysentery, knife injury.
Radix Clerodenri Cyrtophylli: base is former: be the root of Verbenaceae Herba Diclipterae Chinensis.Nature and flavor: bitter, cold.Function cures mainly: heat clearing away, and removing toxic substances, dispels the wind, dehumidifying.Control encephalitis b, epidemic encephalitis, the high heat of flu, headache, enteritis, dysentery, jaundice, toothache, epistaxis, laryngopharynx swelling and pain.
Rhizoma Acori Graminei: base is former: be the rhizome of South, sky section phytobezoar Rhizoma Acori Graminei.Nature and flavor: pungent, bitter, temperature.Gui Jing: GUIXIN, stomach warp.Function cures mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
Stigma Croci: base is former: be the stigma of irides Stigma Croci.Nature and flavor: property is put down, sweet in the mouth.Gui Jing: the heart, Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization., palpitation with fear vexed for amenorrhea lump in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is gone mad.
Radix Cynanchi Amplexicaulis: base is former: be root or the herb of asclepiadaceae plant Radix Cynanchi Amplexicaulis.Nature and flavor: micro-hardship are flat, nontoxic.Function cures mainly: heat clearing away, wind-damp dispelling, subduing swelling and detoxicating.Control acute gastroenteritis, acute hepatitis, rheumatalgia, migraine, have blood in stool, carbuncle, eczema.
Rhodobryum roseum Limpr.: base is former: be the herb of the red great Ye moss of Bryaceae plant.Nature and flavor: pungent, bitter are flat.Function cures mainly: tranquilizing by nourishing the heart, liver heat removing and eyesight improving.For severe palpitation, neurasthenia, conjunctival congestion and swelling pain is controlled in external.
Radix Angelicae Sinensis: base is former: be the root of umbelliferae angelica.Nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
embodiment 1treat ARR Chinese medicine preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 12 parts, Fructus Choerospondiatis 10 parts, Radix anthrisci 8 parts, Herba Ajugae 9 parts, 11 parts, Fructus Hordei Germinatus, succinum 7 parts, Radix ceratostigmatis willemottiani 9 parts, Caulis te Folium Callicarpae Longissimae 6 parts, Herba Wahlenbergiae 10 parts, Radix Clerodenri Cyrtophylli 8 parts, Rhizoma Acori Graminei 7 parts, Stigma Croci 9 parts, Radix Cynanchi Amplexicaulis 7 parts, Rhodobryum roseum Limpr. 10 parts, Radix Angelicae Sinensis 11 parts.
The preparation method of the ARR Chinese medicine preparation powder of above-mentioned treatment is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, big fire boils 25 minutes, filter, collect filtrate, operate three times, three amount of water are 7 times of boiled crude drug quality, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, obtain powder.
embodiment 2treat ARR Chinese medicine preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 20 parts, Fructus Choerospondiatis 15 parts, Radix anthrisci 13 parts, Herba Ajugae 15 parts, 14 parts, Fructus Hordei Germinatus, succinum 15 parts, Radix ceratostigmatis willemottiani 13 parts, Caulis te Folium Callicarpae Longissimae 14 parts, Herba Wahlenbergiae 15 parts, Radix Clerodenri Cyrtophylli 15 parts, Rhizoma Acori Graminei 14 parts, Stigma Croci 12 parts, Radix Cynanchi Amplexicaulis 13 parts, Rhodobryum roseum Limpr. 13 parts, Radix Angelicae Sinensis 17 parts.
The preparation method for the treatment of ARR Chinese medicine preparation tablet is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, amount of water is 7 times of boiled crude drug quality, big fire boils 25 minutes, filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, make medicated powder, add starch, dried starch mixing, add 10% starch slurry mixing soft material processed, cross 16 mesh sieves to granulate, 60 DEG C of dryings, cross 12 mesh sieve granulate, add lubricant, tabletting, obtains tablet.
Model case: xxx, man, 46 years old.Main suit: dizzy cardiopalmus three months, increases the weight of one week.The nearly comparatively fatigue that works over the past half year, after fatigue, self-induction is dizzy, and rear appearance is uncomfortable in chest, breathe hard, within nearly one week, with general weakness, bitter taste is done, agitation, examination in hospital, red tongue, yellow and thin fur, thready and rapid pulse, Electrocardioscopy, sinus tachycardia, myocardial strain, II, III, aVF leads inversion, is diagnosed as myocarditis arrhythmia.
Take the present embodiment gained and treat ARR Chinese medicine preparation tablet, every day 3 times, each 4, warm water delivery service, 7 days courses for the treatment of.After taking one week, dizzy, uncomfortable in chest, disappearance of breathing hard, ECG core yield declines, II, III, aVF transfers Horizon to, after taking three courses for the treatment of, all diseases disappear entirely, and electrocardiogram recovers normal substantially, consolidate after taking a course for the treatment of, drug withdrawal, take a good rest at ordinary times, after half a year, check normal ECG, follow up a case by regular visits to after 1 year and do not recur.
embodiment 3treat ARR Chinese medicine preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 14 parts, Fructus Choerospondiatis 11 parts, Radix anthrisci 9 parts, Herba Ajugae 10 parts, 12 parts, Fructus Hordei Germinatus, succinum 9 parts, Radix ceratostigmatis willemottiani 10 parts, Caulis te Folium Callicarpae Longissimae 8 parts, Herba Wahlenbergiae 11 parts, Radix Clerodenri Cyrtophylli 10 parts, Rhizoma Acori Graminei 9 parts, Stigma Croci 10 parts, Radix Cynanchi Amplexicaulis 9 parts, Rhodobryum roseum Limpr. 11 parts, Radix Angelicae Sinensis 13 parts.
The preparation method for the treatment of ARR Chinese medicine preparation decoction is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, get Testa Tritici to be sprinkled in hot pot, be heated to smolder, add each raw material tablet and mix thoroughly, and cover one deck Testa Tritici on raw material tablet, little fire is vexed to be taken out to crude drug is surperficial in time yellow, and sieve removes Testa Tritici, dries in the air cool;
(3) get Radix Ginseng and Rhodobryum roseum Limpr. sucrose solution on the rocks boils, the amount of crystal sugar water is 5 times of crude drug quality, boils when reducing by half to water, filters, collect filtrate;
(4) by Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (2) made crude drug, amount of water is 7.5 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 31 minutes, filter, collect filtrate, operation twice, merges twice gained filtrate;
(5) made to step (3) (4) filtrate merged, then add step (1) made medicamental pulverata, mixing, obtains decoction.
Model case: xxx, female, 37 years old.Nearly half a year, intermenstrual period was often had palpitation with cardiopalmus, insomnia xerostomia, dysphoria with feverish sensation in the chest palms and soles, fatigue and weakness, through measuring many and color is red, matter is rare, and after menstrual period, heart rate recovers normal, and examination in hospital red tongue moistens, yellow and thin fur, thready and rapid pulse, other every indexes are all normal, and electrocardiogram display arrhythmia, is diagnosed as cardiopalmus.
Take the present embodiment gained and treat ARR Chinese medicine preparation decoction, adopt every day 3 times, each 300-350ml, warm, 7 days courses for the treatment of.After taking 3 days, palpitation and insomnia alleviates, and after taking a course for the treatment of, all diseases disappear entirely, and the electrocardiogram display rhythm of the heart is normal, and after consolidating a course for the treatment of, drug withdrawal, cardiopalmus does not appear in intermenstrual period, and nervous, the diseases such as insomnia, follow up a case by regular visits to after 1 year, do not recur, normal ECG.
embodiment 4treat ARR Chinese medicine preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 18 parts, Fructus Choerospondiatis 14 parts, Radix anthrisci 12 parts, Herba Ajugae 14 parts, 13 parts, Fructus Hordei Germinatus, succinum 13 parts, Radix ceratostigmatis willemottiani 12 parts, Caulis te Folium Callicarpae Longissimae 12 parts, Herba Wahlenbergiae 14 parts, Radix Clerodenri Cyrtophylli 13 parts, Rhizoma Acori Graminei 12 parts, Stigma Croci 11 parts, Radix Cynanchi Amplexicaulis 11 parts, Rhodobryum roseum Limpr. 12 parts, Radix Angelicae Sinensis 15 parts.
The preparation method for the treatment of ARR Chinese medicine preparation pill is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, amount of water is 7 times of boiled crude drug quality, big fire boils 25 minutes, filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) join in step (4) made clear paste by step (1) (2) made medicamental pulverata and medicated powder, mixing, lyophilization, pulverized 130 mesh sieves, made medicated powder, added water generally to make ball, obtained pill.
Model case: xxx, man, 60 years old.Medical history: coronary heart disease, paroxysmal auricular fibrillation medical history 3 years, takes enteric coated aspirin sheet, digoxin throughout the year, the treatment of the medicine such as cedilanid, angry processus aboralis sense cardiopalmus before two days, nervous, uncomfortable in chest, breathe hard, dizziness, weak, after taking SUXIAO JIUXIN WAN, remission, but still sense is uncomfortable, hospital just controls, light red tongue, tongue is white, irregularly rapid pulse, rapid heart rate, not etc., arrhythmia, is not diagnosed as the vibration of rapidity new house to hear sounds power.
Take the present embodiment gained and treat ARR Chinese medicine preparation pill, adopt every day 3 times, each 4, with warm water delivery service, 7 days courses for the treatment of.Take two days later, cardiopalmus, the symptom such as to breathe hard alleviate, and after taking a course for the treatment of, shortness of breath and palpitation obviously alleviates, and heart rate obviously declines, and after taking four courses for the treatment of, all diseases of patient disappear entirely, and electrocardiogram recovers normal, and patient's arrhythmia disappears, and follows up a case by regular visits to and do not recur after 1 year.
embodiment 5treat ARR Chinese medicine preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 16 parts, Fructus Choerospondiatis 12.5 parts, Radix anthrisci 10.5 parts, Herba Ajugae 12 parts, 12.5 parts, Fructus Hordei Germinatus, succinum 11 parts, Radix ceratostigmatis willemottiani 11 parts, Caulis te Folium Callicarpae Longissimae 10 parts, Herba Wahlenbergiae 12.5 parts, Radix Clerodenri Cyrtophylli 11.5 parts, Rhizoma Acori Graminei 10.5 parts, Stigma Croci 10.5 parts, Radix Cynanchi Amplexicaulis 10 parts, Rhodobryum roseum Limpr. 11.5 parts, Radix Angelicae Sinensis 14 parts.
The preparation method for the treatment of ARR Chinese medicine preparation powder is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, big fire boils 25 minutes, filter, collect filtrate, operate three times, three amount of water are 7 times of boiled crude drug quality, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, obtain powder.
test example 1gained of the present invention treats the clinical practice of ARR Chinese medicine preparation (embodiment 5):
In November ,-2014 in October, 2013, filter out 337 routine arrhythmia patients in 5 hospitals, wherein women 158 example, male 179 example, age 28-66 year, the mean age (50.3 ± 5.6) year.All experimenters all meet ARR diagnostic criteria in " cardiovascular disease diagnosis standard ", wherein frequent premature beat 113 example, paroxysmal auricular fibrillation 57 example, permanent atrial fibrillation 63 example, frequent premature ventricular beats 84 example, polyphyly ventricular premature contraction 20 example.Get rid of the factor institute proarrhythmia such as acid base imbalance and electrolyte disturbance, digitalism, hypotension, cardiogenic shock, II to III degree heart block, sick sinus syndrome and severe sinus bradycardia in body.
Patient is divided into two groups at random, experimental group 195 example and matched group 142 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and take every day 3 times (warm), each 5-8g(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of, treat four courses for the treatment of continuously.Matched group takes other medicine (conventional medication such as JIANGZHINING KELI, Guanxi-shengmai ball, sharp heart ball).Period in a medicine Continuous Observation two groups of patient's rhythms of the heart improve situation, record symptom and change.
Curative effect situation criterion: effective: clinical symptom disappearance or substantially disappear, ambulatory electrocardiogram display arrhythmia obviously reduces more than 90% or disappear; Effective: clinical symptoms is obviously improved, ambulatory electrocardiogram display arrhythmia reduces 50% ~ 90%; Invalid: clinical symptoms is without improvement or increase the weight of, electrocardiogram is comparatively treated front without significant change or deterioration.
Through treatment, experimental group patient, effective 105 examples (53.8%), effective 83 examples (42.6%), invalid 7 examples (3.6%) experimental group total effective rate 96.4%; And matched group patient, effective 50(35.2%), effective 61 examples (43.0%), invalid 31 examples (21.8%), matched group total effective rate is 78.2%, known, and the therapeutic effect of matched group is starkly lower than experimental group.Treatments period, there is nauseating, gastrointestinal upset 4 example in experimental group, 2 examples of feeling sick appear in matched group, and sinus bradycardia 3 is routine, and after drug withdrawal, symptom is alleviated automatically, does not cause the infringement that other devices are dirty.
The present invention selects the Radix Ginseng of invigorating QI to relieve exhaustion, the Fructus Choerospondiatis of removing toxic substances pain relieving, the Radix anthrisci of invigorating the spleen and replenishing QI, the Herba Ajugae of heat-clearing and toxic substances removing, the Fructus Hordei Germinatus of removing stagnancy of indigested food and making QI downward, the succinum of tranquillizing and allaying excitement, the Radix ceratostigmatis willemottiani of promoting blood circulation and stopping pain, invigorate blood circulation sterilization Caulis te Folium Callicarpae Longissimae, the Herba Wahlenbergiae that tonify deficiency induces sweat, the Radix Clerodenri Cyrtophylli of expelling wind and removing dampness, the Rhizoma Acori Graminei of eliminating phlegm of having one's ideas straightened out, the Stigma Croci of resolving stagnation for tranquilization, the Radix Cynanchi Amplexicaulis of subduing swelling and detoxicating, the Rhodobryum roseum Limpr. of tranquilizing by nourishing the heart, the Radix Angelicae Sinensis of invigorating blood circulation of enriching blood, each crude drug is collaborative to play a role, and can play the effect such as invigorating the spleen and replenishing QI, tranquilizing by nourishing the heart.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat ARR Chinese medicine preparation, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Radix Ginseng 12-20, Fructus Choerospondiatis 10-15, Radix anthrisci 8-13, Herba Ajugae 9-15, Fructus Hordei Germinatus 11-14, succinum 7-15, Radix ceratostigmatis willemottiani 9-13, Caulis te Folium Callicarpae Longissimae 6-14, Herba Wahlenbergiae 10-15, Radix Clerodenri Cyrtophylli 8-15, Rhizoma Acori Graminei 7-14, Stigma Croci 9-12, Radix Cynanchi Amplexicaulis 7-13, Rhodobryum roseum Limpr. 10-13, Radix Angelicae Sinensis 11-17.
2. the ARR Chinese medicine preparation for the treatment of as claimed in claim 1, it is characterized in that, Radix Ginseng 14-18, Fructus Choerospondiatis 11-14, Radix anthrisci 9-12, Herba Ajugae 10-14, Fructus Hordei Germinatus 12-13, succinum 9-13, Radix ceratostigmatis willemottiani 10-12, Caulis te Folium Callicarpae Longissimae 8-12, Herba Wahlenbergiae 11-14, Radix Clerodenri Cyrtophylli 10-13, Rhizoma Acori Graminei 9-12, Stigma Croci 10-11, Radix Cynanchi Amplexicaulis 9-11, Rhodobryum roseum Limpr. 11-12, Radix Angelicae Sinensis 13-15 is (preferred, Radix Ginseng 16, Fructus Choerospondiatis 12.5, Radix anthrisci 10.5, Herba Ajugae 12, Fructus Hordei Germinatus 12.5, succinum 11, Radix ceratostigmatis willemottiani 11, Caulis te Folium Callicarpae Longissimae 10, Herba Wahlenbergiae 12.5, Radix Clerodenri Cyrtophylli 11.5, Rhizoma Acori Graminei 10.5, Stigma Croci 10.5, Radix Cynanchi Amplexicaulis 10, Rhodobryum roseum Limpr. 11.5, Radix Angelicae Sinensis 14).
3. the ARR Chinese medicine preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, add decocting in water together with step (3) made crude drug, big fire boils 20-30 minute, and (preferred, 22-28 minute is boiled in big fire; Be more preferably, big fire boils 25 minutes), filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, obtain powder.
4. the preparation method of the ARR Chinese medicine preparation powder for the treatment of as claimed in claim 3, is characterized in that, step (4) three amount of water are the 6-8 of boiled crude drug quality doubly (preferred, amount of water is 7 times of boiled crude drug quality).
5. the ARR Chinese medicine preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, amount of water is 7 times of boiled crude drug quality, 20-30 minute is boiled in big fire, filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, make medicated powder, add starch, dried starch mixing, add 10% starch slurry mixing soft material processed, cross 16 mesh sieves to granulate, 60 DEG C of dryings, cross 12 mesh sieve granulate, add lubricant, tabletting, obtains tablet.
6. the preparation method of the ARR Chinese medicine preparation tablet for the treatment of as claimed in claim 5, is characterized in that, step (4) big fire is boiled 22-28 minute (preferred, big fire boils 25 minutes).
7. the ARR Chinese medicine preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, get Testa Tritici to be sprinkled in hot pot, be heated to smolder, add each raw material tablet and mix thoroughly, and cover one deck Testa Tritici on raw material tablet, little fire is vexed to be taken out to crude drug is surperficial in time yellow, and sieve removes Testa Tritici, dries in the air cool;
(3) get Radix Ginseng and Rhodobryum roseum Limpr. sucrose solution on the rocks boils, the amount of crystal sugar water is 5 times of crude drug quality, boils when reducing by half to water, filters, collect filtrate;
(4) by Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (2) made crude drug, amount of water is 7.5 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 25-37 minute, filter, collect filtrate, operation twice, merges twice gained filtrate;
(5) made to step (3) (4) filtrate merged, then add step (1) made medicamental pulverata, mixing, obtains decoction.
8. the preparation method of the ARR Chinese medicine preparation decoction for the treatment of as claimed in claim 7, is characterized in that, step (4) big fire is boiled rear little fire and decocted 28-34 minute (preferred, big fire is boiled rear little fire and decocted 31 minutes).
9. the ARR Chinese medicine preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get succinum to clean, with bean curd with boiling, boiling 10 minutes, taking out, tight with four layers of wet toilet paper parcel, be placed in smokeless hot ash stewing and become coke yellow to surperficial paper, take out, removing paper, cools, grinds into powder;
(2) by Radix anthrisci, Radix ceratostigmatis willemottiani, Herba Wahlenbergiae and Radix Angelicae Sinensis, clean, infiltrate, section, gets Testa Tritici and is sprinkled in hot pot, be heated to smolder, add each raw material tablet to mix thoroughly, and one deck Testa Tritici is covered on raw material tablet, little fire is vexed surperficial in time yellow to crude drug, takes out, sieve removes Testa Tritici, dry in the air cool, pulverize and sieve, make medicated powder;
(3) get Rhodobryum roseum Limpr. sucrose solution on the rocks to boil, the amount of crystal sugar water is 2 times of Rhodobryum roseum Limpr. quality, boils when exhausting to water, takes out, dries, dry in the air cool;
(4) by Radix Ginseng, Fructus Choerospondiatis, Herba Ajugae, Fructus Hordei Germinatus, Caulis te Folium Callicarpae Longissimae, Radix Clerodenri Cyrtophylli, Rhizoma Acori Graminei, Stigma Croci and Radix Cynanchi Amplexicaulis, decocting in water is added together with step (3) made crude drug, amount of water is 7 times of boiled crude drug quality, big fire boils 20-30 minute, and (preferred, 22-28 minute is boiled in big fire; Be more preferably, big fire boils 25 minutes), filter, collect filtrate, operate three times, merge three gained filtrates, and concentrating under reduced pressure becomes clear paste;
(5) step (1) (2) made medicamental pulverata and medicated powder are joined in step (4) made clear paste, mixing, lyophilization, pulverize, make medicated powder, add water and generally make ball, obtain pill.
10. the preparation method of the ARR Chinese medicine preparation pill for the treatment of as claimed in claim 9, is characterized in that, step (5) was pulverized 100-160 mesh sieve and (preferably, pulverized 120-140 mesh sieve; Be more preferably, pulverized 130 mesh sieves).
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0789863A (en) * | 1993-09-24 | 1995-04-04 | Morishita Roussel Kk | Isolation refining method for ginsenoside re and antiarhythmic agent mainly composed of compound |
| CN103721202A (en) * | 2012-10-11 | 2014-04-16 | 王宪凯 | Traditional Chinese medicine pill or treating arrhythmia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0789863A (en) * | 1993-09-24 | 1995-04-04 | Morishita Roussel Kk | Isolation refining method for ginsenoside re and antiarhythmic agent mainly composed of compound |
| CN103721202A (en) * | 2012-10-11 | 2014-04-16 | 王宪凯 | Traditional Chinese medicine pill or treating arrhythmia |
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| Title |
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| 孙继红: "中药复律汤治心律不齐45例", 《陕西中医》 * |
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