CN105031254A - Ointment used for treating dermatitis and preparation method thereof - Google Patents
Ointment used for treating dermatitis and preparation method thereof Download PDFInfo
- Publication number
- CN105031254A CN105031254A CN201510393992.3A CN201510393992A CN105031254A CN 105031254 A CN105031254 A CN 105031254A CN 201510393992 A CN201510393992 A CN 201510393992A CN 105031254 A CN105031254 A CN 105031254A
- Authority
- CN
- China
- Prior art keywords
- parts
- vitamin
- dermatitis
- weight
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 78
- 239000002674 ointment Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 19
- 241001116389 Aloe Species 0.000 claims abstract description 19
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 19
- 239000011787 zinc oxide Substances 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 11
- 235000014692 zinc oxide Nutrition 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 55
- 241000628997 Flos Species 0.000 claims description 41
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 36
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 34
- 239000000843 powder Substances 0.000 claims description 33
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000005325 percolation Methods 0.000 claims description 21
- 241000219112 Cucumis Species 0.000 claims description 19
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims description 19
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 19
- 239000002689 soil Substances 0.000 claims description 19
- 229940099259 vaseline Drugs 0.000 claims description 19
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 18
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 18
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 18
- 229930003471 Vitamin B2 Natural products 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 18
- 239000004006 olive oil Substances 0.000 claims description 18
- 235000008390 olive oil Nutrition 0.000 claims description 18
- 229960002477 riboflavin Drugs 0.000 claims description 18
- 235000019164 vitamin B2 Nutrition 0.000 claims description 18
- 239000011716 vitamin B2 Substances 0.000 claims description 18
- 241000255791 Bombyx Species 0.000 claims description 17
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 17
- 229930003268 Vitamin C Natural products 0.000 claims description 17
- 239000002671 adjuvant Substances 0.000 claims description 17
- 235000019154 vitamin C Nutrition 0.000 claims description 17
- 239000011718 vitamin C Substances 0.000 claims description 17
- 229930003427 Vitamin E Natural products 0.000 claims description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 16
- 235000019165 vitamin E Nutrition 0.000 claims description 16
- 239000011709 vitamin E Substances 0.000 claims description 16
- 229940046009 vitamin E Drugs 0.000 claims description 16
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 15
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 15
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 15
- 235000019155 vitamin A Nutrition 0.000 claims description 15
- 239000011719 vitamin A Substances 0.000 claims description 15
- 229940045997 vitamin a Drugs 0.000 claims description 15
- 230000001476 alcoholic effect Effects 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 229930003451 Vitamin B1 Natural products 0.000 claims description 13
- 229960003495 thiamine Drugs 0.000 claims description 13
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 13
- 235000010374 vitamin B1 Nutrition 0.000 claims description 13
- 239000011691 vitamin B1 Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 229940088594 vitamin Drugs 0.000 claims description 9
- 229930003231 vitamin Natural products 0.000 claims description 9
- 235000013343 vitamin Nutrition 0.000 claims description 9
- 239000011782 vitamin Substances 0.000 claims description 9
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 9
- 229960005150 glycerol Drugs 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 229960001296 zinc oxide Drugs 0.000 claims description 8
- 230000000694 effects Effects 0.000 abstract description 46
- 206010000496 acne Diseases 0.000 abstract description 17
- 208000010668 atopic eczema Diseases 0.000 abstract description 14
- 208000003251 Pruritus Diseases 0.000 abstract description 12
- 201000008937 atopic dermatitis Diseases 0.000 abstract description 7
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 6
- 206010014198 Eczema infantile Diseases 0.000 abstract description 6
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 6
- 230000002458 infectious effect Effects 0.000 abstract description 3
- 230000000857 drug effect Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000906579 Actaea cimicifuga Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241001313857 Bletilla striata Species 0.000 abstract 1
- 241000255789 Bombyx mori Species 0.000 abstract 1
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 241001180876 Saposhnikovia Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 240000000890 Trichosanthes cucumeroides Species 0.000 abstract 1
- 235000018854 Trichosanthes cucumeroides Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940105847 calamine Drugs 0.000 abstract 1
- 235000005301 cimicifuga racemosa Nutrition 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052864 hemimorphite Inorganic materials 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 28
- 210000003491 skin Anatomy 0.000 description 26
- 231100000614 poison Toxicity 0.000 description 19
- 210000004369 blood Anatomy 0.000 description 18
- 239000008280 blood Substances 0.000 description 17
- 239000003440 toxic substance Substances 0.000 description 15
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 14
- 210000004072 lung Anatomy 0.000 description 14
- 230000008961 swelling Effects 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 10
- 201000010099 disease Diseases 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 206010007247 Carbuncle Diseases 0.000 description 8
- 206010061218 Inflammation Diseases 0.000 description 8
- 238000011084 recovery Methods 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
- 230000004054 inflammatory process Effects 0.000 description 7
- 206010017553 Furuncle Diseases 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 6
- 239000012467 final product Substances 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 230000001139 anti-pruritic effect Effects 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 210000002429 large intestine Anatomy 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 201000000297 Erysipelas Diseases 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- 206010040943 Skin Ulcer Diseases 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 241000700647 Variola virus Species 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000003908 antipruritic agent Substances 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 231100000019 skin ulcer Toxicity 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 3
- 241000475481 Nebula Species 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- 150000001746 carotenes Chemical class 0.000 description 3
- 235000005473 carotenes Nutrition 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 201000007227 lymph node tuberculosis Diseases 0.000 description 3
- 206010037844 rash Diseases 0.000 description 3
- 230000000306 recurrent effect Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 3
- 241000208365 Celastraceae Species 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 206010021531 Impetigo Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- PUPKKEQDLNREIM-UHFFFAOYSA-N Kaempferitin Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(OC3C(C(O)C(O)C(C)O3)O)=C(C=3C=CC(O)=CC=3)OC2=C1 PUPKKEQDLNREIM-UHFFFAOYSA-N 0.000 description 2
- 206010025421 Macule Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 235000000336 Solanum dulcamara Nutrition 0.000 description 2
- XWCYDHJOKKGVHC-UHFFFAOYSA-N Vitamin A2 Chemical compound OCC=C(C)C=CC=C(C)C=CC1=C(C)C=CCC1(C)C XWCYDHJOKKGVHC-UHFFFAOYSA-N 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- SOSLMHZOJATCCP-PADPQNGGSA-N afzelin Natural products O([C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)C1=C(c2ccc(O)cc2)Oc2c(c(O)cc(O)c2)C1=O SOSLMHZOJATCCP-PADPQNGGSA-N 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000004856 capillary permeability Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 210000001126 granulation tissue Anatomy 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- ZMGSKTZDVIZXJS-UHFFFAOYSA-N kaempferitrin Natural products CC1OC(OC2C(Oc3cc(OC4OC(C)C(O)C(O)C4O)cc(O)c3C2=O)c5ccc(O)cc5)C(O)C(O)C1O ZMGSKTZDVIZXJS-UHFFFAOYSA-N 0.000 description 2
- PUPKKEQDLNREIM-QNSQPKOQSA-N kaempferol 3,7-di-O-alpha-L-rhamnoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=CC(O)=C2C(=O)C(O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=C(C=3C=CC(O)=CC=3)OC2=C1 PUPKKEQDLNREIM-QNSQPKOQSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 210000003859 smegma Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000002327 urinary tract obstruction Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 241000905957 Channa melasoma Species 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- SNIXRMIHFOIVBB-UHFFFAOYSA-N N-Hydroxyl-tryptamine Chemical compound C1=CC=C2C(CCNO)=CNC2=C1 SNIXRMIHFOIVBB-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- OBODKGDXEIUEIH-DAWLFQHYSA-N all-trans-3-hydroxyretinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CC(O)CC1(C)C OBODKGDXEIUEIH-DAWLFQHYSA-N 0.000 description 1
- DPRNENKPXAZQBI-UHFFFAOYSA-N alpha-Vitamin A Natural products OCC=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C DPRNENKPXAZQBI-UHFFFAOYSA-N 0.000 description 1
- ILKJAFIWWBXGDU-MOGDOJJUSA-N amcinonide Chemical compound O([C@@]1([C@H](O2)C[C@@H]3[C@@]1(C[C@H](O)[C@]1(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]13)C)C(=O)COC(=O)C)C12CCCC1 ILKJAFIWWBXGDU-MOGDOJJUSA-N 0.000 description 1
- 229960003099 amcinonide Drugs 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 208000010217 blepharitis Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- -1 flavone compound Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229960005010 orotic acid Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000037309 reepithelialization Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an ointment used for treating dermatitis and a preparation method thereof, belonging to the technical field of traditional Chinese medicinal preparations. The ointment used for treating dermatitis mainly comprises active components like honeysuckle flower, bletilla striata, dahurian angelica root, Japanese snakegourd root, calamine, aloe, borneol, wild chrysanthemum flower, fructus forsythia, lightyellow sophora root, red sage root, white batryticated silkworm, largetrifoliolious bugbane rhizome, mulberry leaf, fructus tribuli, divaricate saposhnikovia root, periostracum cicadae, etc. and also comprises accessory materials. Through effective and reasonable combination, mutual cooperation and joint promotion of all the components, the obtained ointment specifically targeted at dermatitis has substantial drug effect, is applicable to a variety of dermatitis like infantile eczema, autosensitive eczema and infectious eczematoid dermatitis, has the advantages of good curative effect, short treatment course, fast action, strong effect, no irritation, safety and reliability, can fundamentally treat dermatitis, shows itching-relieving, acne-removing and spot-removing effect and exerts the effective effect of simultaneous treatment of principal and subordinate symptoms.
Description
(1) technical field
The invention belongs to technical field of traditional Chinese medicine preparation, particularly a kind of unguentum for the treatment of dermatitis and preparation method thereof.
(2) background technology
Dermatitis is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor, comprises the various dermatitis such as diaper dermatitis, contact dermatitis, atoipc dermatitis, eczema-like dermatitis.Dermatitis divides acute, subacute, chronic three phases.Acute stage, tool oozed out tendency, and chronic phase then infiltrates, plumpness.Some patient directly translates into chronic eczema.Skin lesion has pleomorphism, symmetry, pruritus and the easy feature such as recurrent exerbation, the study affecting child with become task efficiency, be the common disease that a kind of many paathogenic factors cause.Existing medicine for external use such as the above-mentioned dermatitis of the treatment such as PIYANPING, PIKANGWANG is difficult to reach the cause of disease, old complaint, complication three comprehensive therapeutical effect, therapeutic effect may be had for above-mentioned dermatosis severe type, if but use for a long time, also effect can be lost, and significantly even not invalid for such effect of drugs of type of state of an illness complexity.Also have the Chinese medicine being used for the treatment of dermatitis or eczema at present, mostly be oral Chinese herbal medicine, Chinese patent medicine, kind is many, and effect is remarkable, and late result is not good, and some external Chinese medicine ointment preparations are because being often mixed with amcinonide in ointment, and curative effect is very micro-, and easy recurrent exerbation.
(3) summary of the invention
In order to make up the deficiencies in the prior art, the invention provides a kind of prepare simple, with strong points, prove effective fast, evident in efficacy and unguentum of the treatment dermatitis had no side effect and preparation method thereof.The unguentum of this treatment dermatitis uses easy to carry, the discomfort of dermatitis, eczema acute pruritus can be alleviated, to severe skin disease such as various dermatitis, eczema, impetigo, there is good therapeutical effect, not containing any hormone medicine, short treating period, late result is good, does not produce any side effect, sequela shape not easily recurs, cure rate is high, and the short-term and the prolonged sickness that solve patient are painful.
The present invention is achieved through the following technical solutions:
Treat a unguentum for dermatitis, its active component is made up of the raw material of following parts by weight:
Flos Lonicerae 10-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Radix Angelicae Dahuricae 10-20 part, soil melon root powder 10-20 part, Calamina 15-25 part, Aloe 10-20 part, Borneolum Syntheticum 4-7 part, Flos Chrysanthemi Indici 10-15 part, Fructus Forsythiae 4-8 part, Radix Sophorae Flavescentis 4-6 part, Radix Salviae Miltiorrhizae 5-10 part, Bombyx Batryticatus 5-10 part, Rhizoma Cimicifugae 5-10 part, Folium Mori 2-6 part, Fructus Atriplicis Sibiricae 4-8 part, Radix Saposhnikoviae 10-20 part, Periostracum Cicadae 15-25 part;
Also comprise the adjuvant of following parts by weight: vitamin B12-8 parts, vitamin B2 2-8 part, Catergen-8 parts, vitamin E2-8 parts, dehydroretinol-8 parts, zinc oxide 1-3 part, glycerol 15-25 part, vaseline 20-25 part, lanoline 15-25 part, olive oil 8-12 part, azone 2-4 part.
The unguentum of this treatment dermatitis, its preferred each active component is made up of the raw material of following parts by weight:
Flos Lonicerae 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, the Radix Angelicae Dahuricae 15 parts, 15 parts, soil melon root powder, Calamina 20 parts, Aloe 15 parts, Borneolum Syntheticum 5 parts, Flos Chrysanthemi Indici 12 parts, Fructus Forsythiae 6 parts, Radix Sophorae Flavescentis 5 parts, Radix Salviae Miltiorrhizae 8 parts, Bombyx Batryticatus 8 parts, Rhizoma Cimicifugae 8 parts, 4 parts, Folium Mori, Fructus Atriplicis Sibiricae 6 parts, Radix Saposhnikoviae 15 parts, Periostracum Cicadae 20 parts;
Also comprise the adjuvant of following parts by weight: VITAMIN B15 part, vitamin B2 5 parts, vitamin C 5 parts, vitamin E 5 parts, vitamin A 5 parts, zinc oxide 1.5 parts, glycerol 20 parts, 23.5 parts, vaseline, lanoline 20 parts, 10 parts, olive oil, azone 3 parts.
The preparation method of the unguentum of this treatment dermatitis, adopts following steps preparation:
A, the Flos Lonicerae of getting above-mentioned parts by weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 10-20 order level micropowder;
B, the micropowder that step a pulverizes is placed in percolator, constantly adds 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added be the 4-8 of micropowder weight doubly;
C, by after step b percolation micropowder take out dry, continue to be crushed to 200-400 order or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned parts by weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, by the mixing of the mixed material of steps d and step e, add the Borneolum Syntheticum of above-mentioned parts by weight, the vortex mixer being placed in 18000-20000rmp/min mixes to ointment shape, to obtain final product.
The present invention treats the usage and dosage of the unguentum of dermatitis: before use, cleaning skin, by paste application in affected part, smears one deck gently at every turn, smears 3-5 times/day.Smear once particularly important before sleeping night, after generally smearing 6-15 days, recovery from illness.
The pharmaceutical characteristic of each active component of the present invention is as follows:
Flos Lonicerae: nature and flavor are sweet, cold.Gas fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Return lung, stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing.Main epidemic febrile disease heating; Toxic-heat and blood stasis; Carbuncle furuncle; Sore throat and multi-infection disease, have removing toxic substances, antiinflammatory, virus killing, sterilization, antipruritic effect, resisting pathogenic microbes.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison, is applicable to various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Application: the title that Flos Lonicerae has from ancient times " panacea of infections section ".Be described as the good medicine protecting the moon, removing heat from blood, heat-clearing and toxic substances removing.Kind removing summer-heat blood poison, for various for skin ulcer, carbuncle, furuncle and phyma, is the heat and toxic materials clearing away medicine that surgery is conventional.Have and strengthen immunity, the function that strengthens the defense effect: be antiinflammatory, antipyretic.Promote the release of adrenocortical hormone, have obvious inhibitory action to inflammation.Also can be used for carbuncle furunculosis, removing toxic substances and promoting subsidence of swelling effect.For carbuncle furuncle poison, congestion and swelling pain, no matter burst pus or routed pus person, uses Flos Lonicerae all can work.
The Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor: bitter sweet, cool.Enter lung meridian.Function cures mainly: tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose; There is expelling pathogenic wind from the body surface, dispersing cold for relieving pain, removing dampness clearing the nasal passage, effect of detumescence and apocenosis and effect.
Soil melon root powder: meridian distribution of property and flavor: bitter in the mouth, cold in nature, returns spleen, stomach warp, containing enriching the Multiple components such as fatty acid, Kaempferitrin, aminoacid, carotene, choline.Effect: there is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of promoting the circulation of blood removing blood stasis with potent drugs.
Calamina: nature and flavor: sweet, flat, returns stomach warp.Function cures mainly: removing nebula is moved back red, receives warm sore.Control cataract, marginal blepharitis eye, ulcer being unable to heal, skin eczema.Effect: removing toxic substances improving acuity of vision and removing nebula, the antipruritic sore of removing dampness.
Aloe: nature and flavor: bitter, cold.Return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Borneolum Syntheticum: meridian distribution of property and flavor: pungent, bitter, is slightly cold; GUIXIN, liver, lung meridian; Effect: promote drug absorption.Promote Transdermal absorption.Transdermal enhancer, can promote drugs through skin mucosa, promote external used medicine Transdermal absorption.Have one's ideas straightened out, antibacterial, antiinflammatory, analgesic activity.Increase granulation tissue structure and reepithelialization, repair mucocutaneous, the acceleration that enhances metabolism completes.
Flos Chrysanthemi Indici: nature and flavor: toil is cool.Enter lung, liver.Function cures mainly: wind and heat dispersing, subduing swelling and detoxicating.Control anemopyretic cold, pneumonia, diphtheria, gastroenteritis: hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters.Pharmacological evaluation proves, Flos Chrysanthemi Indici is natural " antibiotics ", can suppress and kill tens of kinds of antibacterials.Therefore, various inflammation inside and outside treatment human body is widely used in.When comedo is red and swollen from the beginning of appearance, wash face with Flos Chrysanthemi Indici, can controls local inflammation rapidly, prevent the pigmentation caused by comedo.
Fructus Forsythiae: nature and flavor: bitter, cool.Enter the heart, liver, gallbladder meridian.Heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Fructus Forsythiae antimicrobial spectrum is very wide, has obvious antiinflammatory action, can promote the formation of inflammatory barrier, reduces capillary permeability, reduces inflammatory exudation, eliminates the local redness that comedo causes.There is certain inhibitory action to smegma, reduce skin excess oiliness, oily skin is improved to effect of skin quality.Fructus Forsythiae can protect normal skin, reduces the generation of comedo and folliculitis.
Radix Sophorae Flavescentis: nature and flavor: bitter, cold.Enter liver, kidney, large intestine, small intestine meridian.Radix Sophorae Flavescentis heat clearing away, pathogenic fire purging, removing toxic substances, damp eliminating, itching-relieving efficacies are obvious, to from the beginning of comedo can eliminate redness.Can also suppress hypersteatosis, reduce sebum alluvial and form acne, keeping skin smooth finish, is one of key agents preventing comedo.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, tepor.Enter the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving.Control angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia, lump in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Radix Salviae Miltiorrhizae is improved blood circulation, suppresses the growth and breeding of propionibacterium acnes in hair follicle, controls comedo and occurs; In addition, before feminine menstrual is risen, in body, androgen increases, and stimulates smegma vigorous, easily raw acne, and Radix Salviae Miltiorrhizae can suppress androgen in body, reduces sebum secretion, and comedo appears in prevention " particular time ".
Bombyx Batryticatus: nature and flavor: Xin Xian, flat.Enter liver, lung, stomach warp.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis.Allly affect beautiful person because depression of liver-QI causes the smooth or phlegm-heat internal-node of QI and blood and commonly use it." Bencao Jingshu " is called: " lung governing skin and hair, and ailment said due to cold or exposure visitor, is then complexion not smooth, pungent temperature people lung, all wind of peeling skin, therefore it is black to go out? and all skin ulcer cicatrixs are also ".As, just there is this medicine the seven white the insides of son.
Rhizoma Cimicifugae: nature and flavor: sweet pungent micro-hardship is cool.Return lung, spleen, stomach, large intestine channel.Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, uterine prolapse.
Folium Mori: nature and flavor: bitter sweet, cold.Folium Mori are good at loose wind heat and eliminating the pathogens from the lung is hot, not only can be used for the conjunctival congestion photophobia that wind heat causes, and can clearing away liver-fire, and effective in cure to the conjunctival congestion and swelling pain of flaming up of liver-fire, to controlling, dark brown speckle is effective.Containing various active compositions such as flavone compound, volatile oil, aminoacid and polysaccharides of Folium Mori in Folium Mori.Folium Mori contain the various trace elements of flavonoid glycoside, phenols, aminoacid, organic acid, carotene, vitamin B1 and needed by human body.
Fructus Atriplicis Sibiricae: acrid in the mouth, hardship, slightly warm in nature, master enters Liver Channel.Dispersing the stagnated live-QI to relieve the stagnation of QI, circulation of qi promoting removing blood stasis.All depression of liver-QI, the smooth caused complexion of QI and blood is dim, furuncle or eyes illness, all can use this medicine, more multiplex in beauty treatment side.
Radix Saposhnikoviae: acrid in the mouth, warm in nature, Gan Buhuan is not high, and property is not only dispersed but also can win wet.All can use for the illness because of the women's head-ornaments caused by wind and cold, rheumatism, pathogenic wind-warm and the whole body, be one of medicine that in beauty treatment side, the frequency of occurrences is the highest.
Periostracum Cicadae: sweet in the mouth, cold in nature, enter lung, Liver Channel.Quality is very light, frivolously should fall apart, heat clearing away cold in nature again, thus in the side such as, eczema, acne rosacea swollen in treatment Head And Face skin ulcer, mainly with dispelling wind pathogens, loose clear interior-heat of holding concurrently, can be antipruritic, again can nebula removing.So often use this in U.S. eye, itching-stopping prescription.
The adjuvants such as vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil, azone are added in the above-mentioned active component of this treatment dermatitis unguentum, effect that is moist, that repair can be had to the skin at dermatitis position, the sterilization of medicament, antiseptic property can be strengthened, be more conducive to plaster products molding.Vitamin ingredients can strengthen speckle dispelling, the anti-acne effect of unguentum to a certain extent.The effect for the treatment of in the unguentum of dermatitis in the present invention of each composition is as follows above:
Vitamin B1: effect: the necessary material of skin histology, promotes normal skin tissue's restore funcitons.
Vitamin B2: effect: participate in biological oxidation and energy metabolism in body, relevant with the metabolism of carbohydrate, protein, nucleic acid and fat, the utilization rate of human body to protein can be improved, enhancing development, safeguard the integrity of skin and cell membrane.There is the function of protection skin follicle mucosa and sebaceous gland.
Vitamin C: effect: vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), the metabolism of phenylalanine, tyrosine, folic acid, the utilization of ferrum, carbohydrate, the synthesis of fat, protein, maintains immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required.
Vitamin E: effect: Wheat Protein.Capillary of skin resistance can be strengthened, and maintain normal permeability, improve blood circulation and adjustment reproductive function, anti-aging effects etc.
Vitamin A: effect: growth promoting effects and reproduction, contributes to protecting epidermis, and mucosa is not by bacterial infestation.
Zinc oxide: effect: convergence and certain sterilizing ability.
Glycerol: effect: have outside moisturizing, humectation function, also has high activity, antioxidation, short alcoholization.
Vaseline (in vain): effect: keep skin wet, makes the skin histology of wound location keep optimum state, accelerates the repair ability of skin self.In addition, vaseline does not have sterilizing ability, and it only blocks from the antibacterial in air and contact skin, thus reduces the probability of infection.
Lanoline: effect: moistness material.Drying or rough skin because lacking natural moisture can be made to soften and be restored.It is by postponing, instead of stops moisture to maintain the common water content of skin through epidermal area completely.
Olive oil: effect: anti-inflammation, short absorption, blood circulation promoting, nourishing effect.
Azone: effect: penetrating agent.
Above composition is prepared into unguentum after processing allotment, be applicable to acute, chronic and allergic dermatitis, effectively can alleviate and remove the various discomfort such as pruritus, long pox that dermatitis causes to patient, to severe skin disease such as various dermatitis, eczema, impetigo, there is good therapeutical effect, pruritus can be eliminated, dispel small pox, there is spot-removal function simultaneously.This product is not containing hormone, and effective ingredient energy rapid osmotic absorbs, and reaches effect of rapid relief of symptoms, ensures that disease is cured substantially or recurrent interval time extends.
The unguentum of this treatment dermatitis, by suitably being coordinated by multi-medicament, utilizes the collaborative or resistant function that it is mutual, and compatibility goes out better to play drug effect and the special unguentum for dermatitis, lastingly evident in efficacy.Flos Lonicerae, Aloe, Rhizoma Cimicifugae, Periostracum Cicadae are cold in nature, there is the merit of clearing away heat and cooling blood, removing toxic substances, rash, coordinate the Pseudobulbus Bletillae (Rhizoma Bletillae), soil melon root powder, Folium Mori, there is effect of heat-clearing and toxic substances removing, antiinflammatory, sterilization, antagonism heat in blood poison is contained, prevent pathological changes and the state of an illness aggravation of inflammation, slow down the various discomforts such as pruritus, remove pox scar pox print; Soil melon root powder is owing to containing the abundant Multiple components such as fatty acid, Kaempferitrin, aminoacid, carotene, choline, its heat-clearing and toxic substances removing can not only be played, dispersing swelling and dissipating binds, the therapeutic efficiency of promoting the circulation of blood removing blood stasis with potent drugs, the absorption of each nutrient of dermatitis patients can also be supplemented, promote the health of body, enhancing human body immunity power; Radix Angelicae Dahuricae removing dampness, dispersing cold for relieving pain, coordinate Calamina, Radix Sophorae Flavescentis, can the antipruritic sore of removing dampness, skin expansion blood capillary, reducing swelling and alleviating pain, and the acceleration that enhances metabolism completes; Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae fall apart blood blood stasis removing, subduing swelling and relieving pain, coordinate Fructus Forsythiae, can reparation, dredging the meridian be realized to eczema position, improve microcirculation and capillary permeability targetedly, alleviate and ooze out and inflammatory reaction, promote wound surface inflammatory to absorb and granulation tissue growth, controls local inflammation, keep skin smoothly bright and clean, the pox that disappears acne removing prints; Borneolum Syntheticum, the Radix Angelicae Dahuricae, Fructus Forsythiae are arranged in pairs or groups mutually, can not only sensiblely dehumidify, and also can promote drugs through skin mucosa, promote external used medicine Transdermal absorption; Fructus Atriplicis Sibiricae, Radix Saposhnikoviae have the use for the treatment of and improvement to facial disease disease, obscure to complexion, facial inflammation, speckle have reparation and therapeutical effect, are also common medicines in beauty treatment side.Owing to wherein with the addition of vitamin B1, B2, vitamin C, vitamin E and vitamin A, while treatment, skin tissue recovering can be promoted further, improve blood circulation, enhance metabolism, enhancing human body immunity power; The pigmentation at dermatitis position can also be prevented simultaneously, reduce growth and the diffusion of speckle.The unguentum of this treatment dermatitis breaches western medical treatment limitation, can QI and blood regulating to greatest extent, improve blood circulation, promote and adjust the immune function of body, transfer the resistance against diseases of human body inherence, the balance of adjustment body and external environment, and regulate the dynamic equilibrium of human body, make up lung, spleen on the whole, damage of suffering from a deficiency of the kidney, improve physical function, thus reach the object of cure diseases.Above medicine cooperatively interacts, Comprehensive Treatment, can play the effect of removing toxic substances and promoting subsidence of swelling, loose wind heat clearing away, removing obstruction in the collateral to relieve pain, and the meridians of dredging diseased region, enhance metabolism, and recover the normal function of diseased region, plays specimen and to hold concurrently the effect of system.
The unguentum for the treatment of dermatitis of the present invention is according to Chinese medicine compatibility theory, in conjunction with clinical empirical summary, obtain through repetition test, preparation technology is simple, easy to operate, have the effects such as removing dampness is antipruritic, expelling wind and clearing away heat, removing toxic substances and promoting subsidence of swelling, removing acne and freckle, have good curative effect to dermatitis such as infantile eczema, autosensitization eczema, infectious eczematoid dermatitis, curative effect is short, prove effective rapidly, effect is strong, and nonirritant is safe and reliable, fundamentally can treat dermatitis, played the useful effect for the treatment of both the principal and secondary aspects of a disease, without recurrence or relapse rate low, have no side effect; Use after making unguentum and carry convenient, also further increasing availability and the curative effect of each ingredient.
This strain ointment, the not super required standard of content, be therefore applicable to the various age, all kinds patient, using method is easy, short treating period, cures fast, without any side effects, can carry with.
(4) detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto.
Embodiment 1:
The unguentum of this treatment dermatitis, its active component is made up of the raw material of following weight:
Flos Lonicerae 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Angelicae Dahuricae 15g, soil melon root powder 15g, Calamina 20g, Aloe 15g, Borneolum Syntheticum 5g, Flos Chrysanthemi Indici 12g, Fructus Forsythiae 6g, Radix Sophorae Flavescentis 5g, Radix Salviae Miltiorrhizae 8g, Bombyx Batryticatus 8g, Rhizoma Cimicifugae 8g, Folium Mori 4g, Fructus Atriplicis Sibiricae 6g, Radix Saposhnikoviae 15g, Periostracum Cicadae 20g;
Also comprise the adjuvant of following weight: VITAMIN B15 g, vitamin B2 5g, vitamin C 5g, vitamin E 5g, vitamin A 5g, zinc oxide 1.5g, glycerol 20g, vaseline 23.5g, lanoline 20g, olive oil 10g, azone 3g.
The preparation method of the unguentum of this treatment dermatitis, adopts following steps:
A, the Flos Lonicerae of getting above-mentioned weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 10 order level micropowders;
B, the micropowder that step a pulverizes is placed in percolator, constantly adds 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added be the 4-of micropowder weight doubly;
C, by after step b percolation micropowder take out dry, continue to be crushed to 400 orders or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, mixed and add the Borneolum Syntheticum of above-mentioned weight by the mixed material of steps d and step e, the vortex mixer being placed in 18000rmp/min mixes to ointment shape, to obtain final product.
Usage and dosage: before use, cleaning skin, by paste application in affected part, smears one deck gently at every turn, smears 3-5 times/day.Smear once particularly important before sleeping night, after generally smearing 6-15 days, recovery from illness.
Embodiment 2:
The unguentum of this treatment dermatitis, its active component is made up of the raw material of following weight:
Flos Lonicerae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Angelicae Dahuricae 10g, soil melon root powder 10g, Calamina 15g, Aloe 10g, Borneolum Syntheticum 4g, Flos Chrysanthemi Indici 10g, Fructus Forsythiae 4g, Radix Sophorae Flavescentis 4g, Radix Salviae Miltiorrhizae 5g, Bombyx Batryticatus 5g, Rhizoma Cimicifugae 5g, Folium Mori 2g, Fructus Atriplicis Sibiricae 4g, Radix Saposhnikoviae 10g, Periostracum Cicadae 15g;
Also comprise the adjuvant of following weight: vitamin B12 g, vitamin B2 2g, Catergen g, vitamin E2 g, dehydroretinol g, zinc oxide 1g, glycerol 15g, vaseline 20g, lanoline 15g, olive oil 8g, azone 4g.
The preparation method of the unguentum of this treatment dermatitis, adopts following steps:
A, the Flos Lonicerae of getting above-mentioned weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 20 order level micropowders;
B, be placed in percolator by the micropowder that step a pulverizes, constantly add 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added is 8 times of micropowder weight;
C, by after step b percolation micropowder take out dry, continue to be crushed to 200 orders or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, mixed and add the Borneolum Syntheticum of above-mentioned weight by the mixed material of steps d and step e, the vortex mixer being placed in 20000rmp/min mixes to ointment shape, to obtain final product.
Usage and dosage, with embodiment 1, no longer describes in detail herein.
Embodiment 3:
The unguentum of this treatment dermatitis, its active component is made up of the raw material of following weight:
Flos Lonicerae 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Angelicae Dahuricae 20g, soil melon root powder 20g, Calamina 25g, Aloe 20g, Borneolum Syntheticum 7g, Flos Chrysanthemi Indici 15g, Fructus Forsythiae 8g, Radix Sophorae Flavescentis 6g, Radix Salviae Miltiorrhizae 10g, Bombyx Batryticatus 10g, Rhizoma Cimicifugae 10g, Folium Mori 6g, Fructus Atriplicis Sibiricae 8g, Radix Saposhnikoviae 20g, Periostracum Cicadae 25g;
Also comprise the adjuvant of following weight: vitamin B1 8g, vitamin B2 8g, vitamin C 8g, vitamin E 8g, vitamin A 8g, zinc oxide 3g, glycerol 25g, vaseline 25g, lanoline 25g, olive oil 12g, azone 4g.
The preparation method of the unguentum of this treatment dermatitis, adopts following steps:
A, the Flos Lonicerae of getting above-mentioned weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 10 order level micropowders;
B, be placed in percolator by the micropowder that step a pulverizes, constantly add 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added is 6 times of micropowder weight;
C, by after step b percolation micropowder take out dry, continue to be crushed to 300 orders or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, mixed and add the Borneolum Syntheticum of above-mentioned weight by the mixed material of steps d and step e, the vortex mixer being placed in 20000rmp/min mixes to ointment shape, to obtain final product.
Usage and dosage, with embodiment 1, no longer describes in detail herein.
Embodiment 4:
The unguentum of this treatment dermatitis, its active component is made up of the raw material of following weight:
Flos Lonicerae 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Radix Angelicae Dahuricae 12g, soil melon root powder 12g, Calamina 18g, Aloe 12g, Borneolum Syntheticum 4g, Flos Chrysanthemi Indici 11g, Fructus Forsythiae 5g, Radix Sophorae Flavescentis 4g, Radix Salviae Miltiorrhizae 6g, Bombyx Batryticatus 6g, Rhizoma Cimicifugae 6g, Folium Mori 3g, Fructus Atriplicis Sibiricae 5g, Radix Saposhnikoviae 12g, Periostracum Cicadae 17g;
Also comprise the adjuvant of following weight: orotic acid g, vitamin B2 3g, vitamin C 3g, vitamin E 3g, 3-Hydroxyretinol g, zinc oxide 2g, glycerol 18g, vaseline 22g, lanoline 18g, olive oil 9g, azone 2g.
The preparation method of the unguentum of this treatment dermatitis, adopts following steps:
A, the Flos Lonicerae of getting above-mentioned weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 10 order level micropowders;
B, be placed in percolator by the micropowder that step a pulverizes, constantly add 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added is 5 times of micropowder weight;
C, by after step b percolation micropowder take out dry, continue to be crushed to 300 orders or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, mixed and add the Borneolum Syntheticum of above-mentioned weight by the mixed material of steps d and step e, the vortex mixer being placed in 18000rmp/min mixes to ointment shape, to obtain final product.
Usage and dosage, with embodiment 1, no longer describes in detail herein.
Embodiment 5:
The unguentum of this treatment dermatitis, its active component is made up of the raw material of following weight:
Flos Lonicerae 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) 18g, Radix Angelicae Dahuricae 18g, soil melon root powder 18g, Calamina 22g, Aloe 18g, Borneolum Syntheticum 6g, Flos Chrysanthemi Indici 14g, Fructus Forsythiae 7g, Radix Sophorae Flavescentis 5g, Radix Salviae Miltiorrhizae 9g, Bombyx Batryticatus 9g, Rhizoma Cimicifugae 9g, Folium Mori 5g, Fructus Atriplicis Sibiricae 7g, Radix Saposhnikoviae 18g, Periostracum Cicadae 22g;
Also comprise the adjuvant of following weight: vitamin B1 6g, vitamin B2 6g, vitamin C 6g, vitamin E 6g, vitamin A 6g, zinc oxide 3g, glycerol 22g, vaseline 24g, lanoline 22g, olive oil 11g, azone 4g.
The preparation method of the unguentum of this treatment dermatitis, adopts following steps:
A, the Flos Lonicerae of getting above-mentioned weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 10 order level micropowders;
B, be placed in percolator by the micropowder that step a pulverizes, constantly add 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added is 7 times of micropowder weight;
C, by after step b percolation micropowder take out dry, continue to be crushed to 400 orders or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, mixed and add the Borneolum Syntheticum of above-mentioned weight by the mixed material of steps d and step e, the vortex mixer being placed in 20000rmp/min mixes to ointment shape, to obtain final product.
Usage and dosage, with embodiment 1, no longer describes in detail herein.
Clinical observation:
One, adopt the treatment situation of unguentum to infantile eczema of embodiment of the present invention 1-5 arbitrary treatment dermatitis as follows:
1, choose case history and meet diagnosis infantile eczema.
2, criterion of therapeutical effect:
Recovery from illness: face or the red disappearance of eczema at other positions of health, noresidue vestige, baby cries and screams minimizing;
Take a turn for the better: eczema reduces in a large number, occasionally have fragmentary remaining red point;
Do not heal: symptom is unchanged.
3, Therapeutic Method:
By paste application of the present invention in affected part, smear one deck gently at every turn, smear 3 times/day.Select to smear during baby sleeping, after generally smearing 6-15 days, recovery from illness.
Matched group selects the precious frost (child form) of Huang Um hall board profit to smear, and smears one deck gently at every turn, smears 3 times/day.Select to smear during baby sleeping.
Clinical case history test 100 example, the neonate of course of disease 1-20 days, monthly age 1-2 month, each 50 people for the treatment of group, matched group.Symptom improvement situation after 1 week for the treatment of is as shown in table 1 below:
Group | Recovery from illness | Take a turn for the better | Do not heal | Effective percentage % |
Treatment group | 30 | 18 | 2 | 96 |
Matched group | 19 | 20 | 11 | 78 |
As can be seen from the above table, two groups of each 50 routine infantile eczema patients, when the paste application treatment carrying out this treatment dermatitis, high for the precious frost of infantile eczema treatment Huang Um hall board profit (child form) curative effect more on the market, and effective percentage is apparently higher than matched group.Followed up a case by regular visits to through one month, treatment group has no recurrence, matched group then in the winter time indoor temperature slightly high (> 25 DEG C) time occur recurrence situation.
Two, adopt the treatment situation of unguentum to adult's eczematoid dermatitis (body sensitivity eczema and infectious eczematoid dermatitis) of embodiment of the present invention 1-5 arbitrary treatment dermatitis as follows:
1, choose case history and meet diagnosis eczematoid dermatitis.
2, criterion of therapeutical effect:
Recovery from illness: the pimple that gregariousness distributes, papulovesicle and vesicle disappear, pruritus disappears, noresidue vestige; Erythema, sepage and incrustation disappear, and pruritus disappears, noresidue vestige; Small pox disappears, pox scar pox print is eliminated; Face speckle shoals; Health is uncomfortable without other;
Take a turn for the better: pimple, papulovesicle and vesicle reduce in a large number, violent pruritus disappears, and occasionally has gargalesthesia, still has a small amount of remaining pimple; Erythema reduces in a large number, without sepage and incrustation; To there being the patient of small pox to have certain acne-removal function, small pox reduces;
Do not heal: symptom is unchanged.
3, Therapeutic Method:
By paste application of the present invention in affected part, smear one deck gently at every turn, smear 3 times/day.Smear before sleeping evening once, after generally smearing 6-15 days, recovery from illness.
Matched group 1 selects QUMIXIN emulsifiable paste to smear, and smears one deck gently at every turn, smears 3 times/day.
Matched group 2 is selected Jiang Shi to defend skin frost and is smeared, and smears one deck gently at every turn, smears 3 times/day.
Clinical case history tests 225 people, each 75 people for the treatment of group, matched group; Course of disease 1-30 days.Symptom improvement situation after 2 weeks for the treatment of is as shown in the table:
Group | Recovery from illness | Take a turn for the better | Do not heal | Effective percentage % |
Treatment group | 45 | 26 | 4 | 94.7 |
Matched group 1 | 30 | 31 | 14 | 81.3 |
Matched group 2 | 26 | 33 | 16 | 78.6 |
As can be seen from the above table, three groups of each 75 routine eczematoid dermatitis patients, when the paste application treatment carrying out this treatment dermatitis, treating the Western medicine QUMIXIN emulsifiable paste (matched group 1) of eczematoid dermatitis and Chinese medicine Jiang Shi more on the market, to defend skin frost (matched group 2) curative effect all high, and effective percentage is apparently higher than matched group 1 and matched group 2.Followed up a case by regular visits to through one month, treatment group has no recurrence, and the patient of matched group 1 and matched group 2 all has recurrence to occur.
Claims (3)
1. treat a unguentum for dermatitis, it is characterized in that: its active component is made up of the raw material of following parts by weight:
Flos Lonicerae 10-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Radix Angelicae Dahuricae 10-20 part, soil melon root powder 10-20 part, Calamina 15-25 part, Aloe 10-20 part, Borneolum Syntheticum 4-7 part, Flos Chrysanthemi Indici 10-15 part, Fructus Forsythiae 4-8 part, Radix Sophorae Flavescentis 4-6 part, Radix Salviae Miltiorrhizae 5-10 part, Bombyx Batryticatus 5-10 part, Rhizoma Cimicifugae 5-10 part, Folium Mori 2-6 part, Fructus Atriplicis Sibiricae 4-8 part, Radix Saposhnikoviae 10-20 part, Periostracum Cicadae 15-25 part;
Also comprise the adjuvant of following parts by weight: vitamin B12-8 parts, vitamin B2 2-8 part, Catergen-8 parts, vitamin E2-8 parts, dehydroretinol-8 parts, zinc oxide 1-3 part, glycerol 15-25 part, vaseline 20-25 part, lanoline 15-25 part, olive oil 8-12 part, azone 2-4 part.
2. a kind of unguentum for the treatment of dermatitis according to claim 1, is characterized in that: its active component is made up of the raw material of following parts by weight:
Flos Lonicerae 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, the Radix Angelicae Dahuricae 15 parts, 15 parts, soil melon root powder, Calamina 20 parts, Aloe 15 parts, Borneolum Syntheticum 5 parts, Flos Chrysanthemi Indici 12 parts, Fructus Forsythiae 6 parts, Radix Sophorae Flavescentis 5 parts, Radix Salviae Miltiorrhizae 8 parts, Bombyx Batryticatus 8 parts, Rhizoma Cimicifugae 8 parts, 4 parts, Folium Mori, Fructus Atriplicis Sibiricae 6 parts, Radix Saposhnikoviae 15 parts, Periostracum Cicadae 20 parts;
Also comprise the adjuvant of following parts by weight: VITAMIN B15 part, vitamin B2 5 parts, vitamin C 5 parts, vitamin E 5 parts, vitamin A 5 parts, zinc oxide 1.5 parts, glycerol 20 parts, 23.5 parts, vaseline, lanoline 20 parts, 10 parts, olive oil, azone 3 parts.
3. a preparation method for the unguentum for the treatment of dermatitis as claimed in claim 1, is characterized in that: comprise the steps:
A, the Flos Lonicerae of getting above-mentioned parts by weight, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, soil melon root powder, Calamina, Aloe, Flos Chrysanthemi Indici, Fructus Forsythiae, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Rhizoma Cimicifugae, Folium Mori, Fructus Atriplicis Sibiricae, Radix Saposhnikoviae, Periostracum Cicadae mixing, machinery shatters into 10-20 order level micropowder;
B, the micropowder that step a pulverizes is placed in percolator, constantly adds 75% alcoholic solution and carry out percolation, collect the micropowder after leachate and percolation, for subsequent use, the weight of the total alcoholic solution added be the 4-8 of micropowder weight doubly;
C, by after step b percolation micropowder take out dry, continue to be crushed to 200-400 order or nanoscale fine powder;
D, the leachate of step b is evaporated to without ethanol taste, reclaims ethanol, obtain concentrated solution, then mix with the fine powder of step c and stir evenly;
E, get the adjuvant of above-mentioned parts by weight: vitamin B1, vitamin B2, vitamin C, vitamin E, vitamin A, zinc oxide, glycerol, vaseline, lanoline, olive oil and azone, mix and stir evenly;
F, by the mixing of the mixed material of steps d and step e, add the Borneolum Syntheticum of above-mentioned parts by weight, mix to ointment shape, obtain the unguentum of this treatment dermatitis.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510393992.3A CN105031254B (en) | 2015-07-07 | 2015-07-07 | A kind of paste and preparation method thereof for treating dermatitis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510393992.3A CN105031254B (en) | 2015-07-07 | 2015-07-07 | A kind of paste and preparation method thereof for treating dermatitis |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105031254A true CN105031254A (en) | 2015-11-11 |
CN105031254B CN105031254B (en) | 2018-09-18 |
Family
ID=54438614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510393992.3A Active CN105031254B (en) | 2015-07-07 | 2015-07-07 | A kind of paste and preparation method thereof for treating dermatitis |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105031254B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110200901A (en) * | 2019-06-14 | 2019-09-06 | 贵州省习水县人民医院 | A kind of cream preparation that treating subacute eczema and preparation method |
CN114452318A (en) * | 2022-02-22 | 2022-05-10 | 威高(北京)医疗科技有限公司 | Anti-inflammatory traditional Chinese medicine composition for sanitary products and preparation method and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101926919A (en) * | 2009-06-25 | 2010-12-29 | 梁婧卉 | Pure traditional Chinese medicinal lotion for treating skin disease |
CN103720786A (en) * | 2012-10-15 | 2014-04-16 | 戴秀芳 | Traditional Chinese medicine composition used for treating neurodermatitis |
-
2015
- 2015-07-07 CN CN201510393992.3A patent/CN105031254B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101926919A (en) * | 2009-06-25 | 2010-12-29 | 梁婧卉 | Pure traditional Chinese medicinal lotion for treating skin disease |
CN103720786A (en) * | 2012-10-15 | 2014-04-16 | 戴秀芳 | Traditional Chinese medicine composition used for treating neurodermatitis |
Non-Patent Citations (1)
Title |
---|
宋业强等: "赵纯修辩治炎症性皮肤病经验", 《山东中医杂志》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110200901A (en) * | 2019-06-14 | 2019-09-06 | 贵州省习水县人民医院 | A kind of cream preparation that treating subacute eczema and preparation method |
CN114452318A (en) * | 2022-02-22 | 2022-05-10 | 威高(北京)医疗科技有限公司 | Anti-inflammatory traditional Chinese medicine composition for sanitary products and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CN105031254B (en) | 2018-09-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103041111B (en) | Gynaecological perineum care solution and preparation method thereof | |
CN105030621A (en) | Moisturizing and acne removing toner and preparing method thereof | |
CN104208245B (en) | Tinea manus and pedis Traditional Chinese medicine medicated bath and preparation method | |
CN104940727A (en) | Paste for treating rhinitis and preparation method thereof | |
CN104324125B (en) | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof | |
CN101380406B (en) | Medicine for treating cheilitis and preparation method thereof | |
CN101439114B (en) | Chinese medicine for treating burn and scald, and preparation method thereof | |
CN104474391A (en) | Medicine for treating skin itch | |
CN101670044A (en) | Medicine for curing gestational chloasma and preparation method thereof | |
CN105031254A (en) | Ointment used for treating dermatitis and preparation method thereof | |
CN101391065A (en) | Compound semen momordicae and pepper soup for treating acute and chronic pelvic inflammatory diseases | |
CN108721442B (en) | Traditional Chinese medicine composition, preparation and preparation method for treating burns and diaper dermatitis | |
CN103007034A (en) | Traditional Chinese medicine composition used for treatment of residual second-degree burn wound, and preparation method thereof | |
CN105456708B (en) | Medicine for treating cheilitis and preparation method thereof | |
CN104474405A (en) | Traditional Chinese medicine composition for treating chloasma | |
CN107095961A (en) | A kind of instant particles as Chinese medicine and preparation method for being used to treat adolescent acne | |
CN106668295A (en) | Externally-used medicine for treating psoriasis, and preparation method of externally-used medicine | |
CN106728167A (en) | A kind of burn and scald external application sterilizing and itch-relieving ointment | |
CN105012580A (en) | Perineum care solution | |
CN105726789A (en) | Nursing drug preparation for treating bedsore and application thereof | |
CN104784541B (en) | It is a kind of to be used to remove Chinese drugs agentia of acne and preparation method thereof | |
CN104887808A (en) | Periodontitis treatment traditional Chinese medicine preparation | |
CN104984147A (en) | Traditional Chinese medicinal tablet for treating infant scalp folliculitis, and preparation method thereof | |
CN102614406B (en) | Traditional Chinese medicine for preventing and treating obstinate oral mucosal ulcer and its preparation method | |
CN117982592A (en) | Traditional Chinese medicine composition for treating skin injury scar and preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20161009 Address after: Iron caizhizhongxin No. 59 high tech Zone of Ji'nan City Industrial Road, Shandong province 250023, 6 7, building 8, room 6-1201-7 Applicant after: SHANDONG JIACITANG BIOLOGICAL TECHNOLOGY CO., LTD. Address before: Iron caizhizhongxin No. 59 high tech Zone Industrial Road, Ji'nan city Shandong province 250023 Building No. 6 1201 Applicant before: Wang Ruichao |
|
GR01 | Patent grant | ||
GR01 | Patent grant |