CN105030607A - Photoaging-preventing pure natural vegetable oil cleansing lotion and preparation method thereof - Google Patents
Photoaging-preventing pure natural vegetable oil cleansing lotion and preparation method thereof Download PDFInfo
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- FGMPLJWBKKVCDB-BYPYZUCNSA-N (2s)-1-hydroxypyrrolidine-2-carboxylic acid Chemical compound ON1CCC[C@H]1C(O)=O FGMPLJWBKKVCDB-BYPYZUCNSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a photoaging-preventing pure natural vegetable oil cleansing lotion and a preparation method thereof. The photoaging-preventing pure natural vegetable oil cleansing lotion is prepared from water, palm kernel oil mixture, tea seed oil and citric acid. By using the pure natural vegetable oil cleansing lotion for a long term, the damage caused by long-term use of chemical ingredients or chemical synthetic ingredients can be avoided, and the photoaging-preventing pure natural vegetable oil cleansing lotion can prevent photoaging, improve the skin color, remove freckles, resist inflammation and allergies, relieve, treat and remove acne, comedos, psoriasis and eczema, remove cutin and effectively prevent scratch and skin burning sensation caused by shaving.
Description
Technical field
The present invention relates to household chemicals field, be specifically related to a kind of clean skin dew preventing and treating the pure natural plant oil of photoaging and preparation method thereof.
Background technology
Clean skin product is in the market a feast for the eyes, of all shapes and colors, the most common with fancy soap, cleansing milk.Major part product contains chemical composition or chemosynthesis composition, product containing vegetable oil is few, the product of life-time service chemical composition can reduce skin resistance against diseases, main manifestations keeps in dark place, easy allergy, easy long pox etc., in the prior art, the many insights of fancy soap are with the fat acid sodium of animals and plants or the animal and plant fat synthesis Cake-shape soap that is soap base, although have good cleaning force, foaming characteristic and easily washability, but the pH value of its monoblock soap product is between 9.5-10.5, soap body meta-alkalescence, not resistance to hard water, incrustation scale can be produced during washing, form calcium magnesium soap, blocking skin pore, degreasing power is strong, skinfeel is poor.And the pH value 4.5-6.5 of general human body skin, partially weakly acidic, if the soap of human body life-time service meta-alkalescence can make skin feel dry and astringent, there is excitement, easily cause skin problem etc.
In Chinese invention patent ZL200710044428.6, disclose a kind of Subacidity skin-moistening synthetic toilet soap, the pH value of this Subacidity skin-moistening synthetic toilet soap is between 4.5-6.5, close to the weak acid environment of human body skin, degrease power is low, and performance is gentle, can avoid the stimulation to skin in washing process.But there is fancy soap and easily stick with paste rotten shortcoming in water in this formula, and has grains of sand sense.
Therefore; prepare a kind of clean skin dew with cleaning and protecting skin double effects; can solve fancy soap easily sticks with paste rotten in water; and have the shortcoming of grains of sand sense; avoid product meta-alkalescence simultaneously, and avoid the injury that life-time service chemical composition or synthetic chemistry composition bring skin, this product contains the high-quality lubricant component life-time service such as most shea butter, Oleum Camelliae has extraordinary effect to protection skin; not tight after washing, the multi-efficiency such as moisturizing, Sage Extract.
Summary of the invention
The object of this invention is to provide a kind of clean skin dew preventing and treating the pure natural plant oil of photoaging.
The object of the invention is by following technical scheme realize:
Clean skin dew of the present invention, it is prepared from by the raw material of following weight portion:
Water 80-90 part, palm kernel oil blends 12-18 part, Oleum Camelliae 0.2-0.8 part, silver ion 0.1-0.3 part, citric acid 0.1-0.3 part.
Described palm kernel oil blends is made up of palm-kernel oil 40%, Oleum Cocois 20%, Butyrospermum parkii fruit fat (shea butter) 20%, cocoa shell powder 20%.
Another object of the present invention, be to provide a kind of preparation method of clean skin dew, it is prepared from by following processing step:
(1) water is mixed with Oleum Camelliae, palm kernel oil blends, Oleum Camelliae be warming up to 75-85 DEG C of low rate mixing until all dissolve;
(2) at low rate mixing borehole cooling to adding during 35-45 DEG C and citric acid, stir 8-15 minute stop stir;
(3) subpackage.
The rotating speed of described low rate mixing is at less than 200 turns per minute.
When described step (3) is with clean hubble-bubble bottle subpackage, 2 clean skin dew is filtered, first use 100 object screen filtrations, second time 300 object screen filtrations.
Beneficial effect of the present invention is:
In formula of the present invention, palm kernel oil blends has effect that is clean, emulsifying, and Oleum Camelliae can conditioning skin, and adding silver ion solution can antibacterial, mildew-resistant, and citric acid can by the pH regulator of skin cream to faintly acid as pH adjusting agent.Life-time service clean skin dew disclosed by the invention, can prevent and treat photoaging, improve the colour of skin, speckle dispelling, antiinflammatory antiallergic, alleviate, treat and remove acne, blackhead, psoriasis and eczema, exfoliation, and effectively preventing shaves, and scraping of causing injures skin burns sense.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.
embodiment 1
A kind of clean skin dew preventing and treating the pure natural plant oil of photoaging, it is prepared from by the raw material of following weight portion:
Water 8kg, palm kernel oil blends 1.2kg, Oleum Camelliae 0.02kg, silver ion solution 0.01kg, citric acid 0.01kg.
Described palm kernel oil blends is made up of palm-kernel oil 40%, Oleum Cocois 20%, Butyrospermum parkii fruit fat (shea butter) 20%, cocoa shell powder 20%.
It is prepared from by following processing step:
(1) water is mixed with Oleum Camelliae, palm kernel oil blends, Oleum Camelliae be warming up to 75 DEG C of low rate mixings until all dissolve;
(2) add silver ion solution and citric acid when low rate mixing borehole cooling to 35 DEG C, stir and within 8 minutes, stop stirring;
(3) subpackage.
The rotating speed of described low rate mixing is at less than 200 turns per minute.
When described step (3) is with clean hubble-bubble bottle subpackage, 2 clean skin dew is filtered, first use 100 object screen filtrations, second time 300 object screen filtrations.
embodiment 2
A kind of clean skin dew preventing and treating the pure natural plant oil of photoaging, it is prepared from by the raw material of following weight portion:
Water 9kg, palm kernel oil blends 1.8kg, Oleum Camelliae 0.08kg, silver ion solution 0.03kg, citric acid 0.03kg.
Described palm kernel oil blends is made up of palm-kernel oil 40%, Oleum Cocois 20%, Butyrospermum parkii fruit fat (shea butter) 20%, cocoa shell powder 20%.
It is prepared from by following processing step:
(1) water is mixed with Oleum Camelliae, palm kernel oil blends, Oleum Camelliae be warming up to 85 DEG C of low rate mixings until all dissolve;
(2) add silver ion solution and citric acid when low rate mixing borehole cooling to 45 DEG C, stir and within 15 minutes, stop stirring;
(3) subpackage.
The rotating speed of described low rate mixing is at less than 200 turns per minute.
When described step (3) is with clean hubble-bubble bottle subpackage, 2 clean skin dew is filtered, first use 100 object screen filtrations, second time 300 object screen filtrations.
embodiment 3
A kind of clean skin dew preventing and treating the pure natural plant oil of photoaging, it is prepared from by the raw material of following weight portion:
Water 8.5kg, palm kernel oil blends 1.5kg, Oleum Camelliae 0.05kg, silver ion solution 0.02kg, citric acid 0.02kg.
Described palm kernel oil blends is made up of palm-kernel oil 40%, Oleum Cocois 20%, Butyrospermum parkii fruit fat (shea butter) 20%, cocoa shell powder 20%.
It is prepared from by following processing step:
(1) water is mixed with Oleum Camelliae, palm kernel oil blends, Oleum Camelliae be warming up to 80 DEG C of low rate mixings until all dissolve;
(2) add silver ion solution and citric acid when low rate mixing borehole cooling to 40 DEG C, stir and within 10 minutes, stop stirring;
(3) subpackage.
The rotating speed of described low rate mixing is at less than 200 turns per minute.
When described step (3) is with clean hubble-bubble bottle subpackage, 2 clean skin dew is filtered, first use 100 object screen filtrations, second time 300 object screen filtrations.
Experimental example 1
1 material
1.1 materials and preparation clean skin dew are skin dew clean described in the embodiment of the present invention 3.Mice hydroxyproline test kit, purchased from abundant bio tech ltd of upper Hisense.
1.2 animal Kunming mouses, female Mus, body weight 20-25g, 7-8 week age, provided by Guangxi Medical University's Experimental Animal Center.
2 methods
2.1 animal groupings and model preparation
With electric hair clipper, mouse back skin is shaved only, about 2cm × 2cm, baring skin, random point 3 groups:
1, matched group: skin smears a distilled water every day, without other any process;
2, model group: skin smears 1%8-methoxypsoralen (8-MOP) 1 time every day, after 1.5-2h, the UVA giving 190uw irradiates, cumulative exposure 138h (integrated intensity 95J/cm
2), irradiate and terminate bark fetching skin in rear 24h;
3, test group: skin repastes after slightly dry smear 1%8-MOP with the clean skin dew cleaning described in the embodiment of the present invention 3 every day, and after 1.5-2h, the UVA giving 190uw irradiates, cumulative exposure 138h (integrated intensity 95J/cm
2), irradiate and terminate bark fetching skin in rear 24h.
3 groups of simultaneously bark fetching skin tissues, fixing, HE dyeing and Electronic Speculum, and get to organize and carry out hydroxyproline content mensuration simultaneously.
2.2 specimen preparations
2.2.1HE dyeing
The piece of tissue of taking off is immersed 10% formaldehyde fix.After 12h, take out the piece of tissue fixed and carry out wax embedding.After block sections, HE normal dyeing of cutting into slices.
2.2.2 electron microscope specimen preparation
Cervical dislocation puts to death mice, rapid bark fetching skin tissue, and about 3mm × 3mm, is fixed in 4% glutaraldehyde phosphate buffer solution, 4 DEG C, preserves 1h, PBS and rinses, 1% osmic acid, 4 DEG C, rear fixing 1h; PBS rinses; 50%, 70%, 80%, 90%, 100% Gradient elution using ethanol; 100% acetone soaks into 15-30min; Embedding medium embeds; Respectively 37,45,60 DEG C of each 24h polymerizations; The ultrathin section of 50nm is cut into ultramicrotome; Acetic acid uranium and the dual electron staining of lead citrate; Transmission electron microscope observing is taken a picture.
2.2.3 hydroxyproline content measures
Assay method operates according to test kit, meanwhile, detects histone, t check analysis result.
3 results
3.1 perusal matched groups, skin colour is ruddy flexible, and model group skin color is gloomy, poor flexibility, and local is hardening, and alopecia, test group, naked eyes are seen and normal control zero difference.
3.2HE coloration result
Model group comparatively matched group is compared, and occur typical photoaging pathological change: epidermal thickness heterogeneity, often have and come off, skin corium is obviously thickening, and inflammatory cell infiltration is common, and blood capillary is expanded, and hair follicle reduces, the irregular hypertrophy of sebaceous gland.Test group comparatively photoaging group, pathological change has clear improvement, and skin corium is thin compared with photoaging group, and inflammatory cell infiltration is less.
3.3 Electronic Speculum results
The fiber distribution of electricity Microscopic observation skin corium and fibroblastic form, result shows, matched group, and fiber distribution is neat, rule, closely, without phenomenon of rupture, fibroblast profile is clear, and endoplasmic reticulum expansion obviously, is illustrated as fibrocellular protein synthesis function vigorous; Model group, fiber distribution is loose, and irregular distribution appears in local, and have phenomenon of rupture, fibroblast model deformation, profile is irregular, and Cytoplasm is less, and endoplasmic reticulum is less, and has the organelle of variation, illustrates that the protein synthesis of cell is inactive; Test group, obviously improves, and fiber alignment and fibroblast form and organelle are closer to matched group.
The mensuration of 3.4 hydroxyproline contents
Get each group of skin histology mensuration and organize hydroxyproline content, calculating mean value, and do the t check analysis between each group.The results are shown in Table 1.
Table 1 hydroxyproline content measures (hydroxyproline/total protein, x ± s)
| Group | Hydroxyproline content (%) |
| Matched group | 9.47±3.14 |
| Model group | 6.12±2.88 * |
| Test group | 9.38±3.69 & |
Compare with matched group,
*p < 0.05; Compare with model group,
aMP.AMp.Ampp < 0.05.
As shown in Table 1, the hydroxyproline content (hydroxyproline/total protein) of model group comparatively matched group obviously reduces, P < 0.05, the hydroxyproline content of test group is apparently higher than model group, P < 0.05, no significant difference between test group and matched group, P > 0.05.
This experiment mainly have studied the preventive and therapeutic effect of the embodiment of the present invention 3 pairs of skin photoagees, and the gloss of perusal matched group and test group skin and elasticity all comparatively model group have clear improvement; Morphological outcomes is found out, model group epidermal thickness heterogeneity, and skin corium is thickening, and cell infiltration is obvious, and test group has clear improvement, and tissue morphology is close to normal; Electricity Microscopic observation, model group, it is loose that fibrous tissue distribution becomes comparatively contrast, often has fracture, and fibroblast is out of shape, and endoplasmic reticulum is few, and test group comparatively model group have clear improvement; And hydroxyproline content measure also show test group collagen content comparatively model group obviously increase, these experimental results all illustrate, the photoaging of Cordyceps polysaccharide to skin histology has protective effect.
Claims (6)
1. prevent and treat the clean skin dew of the pure natural plant oil of photoaging for one kind, it is characterized in that, it is prepared from by the raw material of following weight portion:
Water 80-90 part, palm kernel oil blends 12-18 part, Oleum Camelliae 0.2-0.8 part, citric acid 0.1-0.3 part.
2. clean skin dew according to claim 1, is characterized in that: described palm kernel oil blends is made up of palm-kernel oil 40%, Oleum Cocois 20%, Butyrospermum parkii fruit fat (shea butter) 20%, cocoa shell powder 20%.
3. clean skin dew according to claim 1, it is characterized in that, it is prepared from by following processing step:
(1), after water being mixed with Oleum Camelliae, palm kernel oil blends, Oleum Camelliae, heat and be stirred to whole dissolving;
(2) continue stir and be cooled to 35-45 DEG C, add citric acid, then after stirring 8-15 minute, stop stirring;
(3) subpackage.
4. described clean skin dew according to claim 3, is characterized in that: the speed of agitator of whole operating process is lower than 200 revs/min.
5. described clean skin dew according to claim 3, is characterized in that: described step (1) heats, and temperature remains 75-85 DEG C.
6. described clean skin dew according to claim 3, is characterized in that: described step (3) subpackage, before employing clean hubble-bubble bottle subpackage, first filters with 100 eye mesh screens, then filter with 300 eye mesh screens.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872172A (en) * | 2005-05-31 | 2006-12-06 | 卡夫食品研发公司 | Polyphenol-enriched composition from cocoa shell extraction |
| CN101732201A (en) * | 2009-12-31 | 2010-06-16 | 玉溪健坤生物药业有限公司 | Reduced coenzyme Q10 essence oil and preparation method thereof |
| CN102416041A (en) * | 2011-12-13 | 2012-04-18 | 成都默森医药开发有限公司 | Antibacterial and anti-inflammatory traditional Chinese medicine composition and preparation method thereof |
| CN102429844A (en) * | 2011-12-07 | 2012-05-02 | 广州青能健日用品有限公司 | Biological environment-friendly anti-oxidation itching-relieving bath foam and preparation method thereof |
-
2015
- 2015-08-07 CN CN201510479623.6A patent/CN105030607A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872172A (en) * | 2005-05-31 | 2006-12-06 | 卡夫食品研发公司 | Polyphenol-enriched composition from cocoa shell extraction |
| CN101732201A (en) * | 2009-12-31 | 2010-06-16 | 玉溪健坤生物药业有限公司 | Reduced coenzyme Q10 essence oil and preparation method thereof |
| CN102429844A (en) * | 2011-12-07 | 2012-05-02 | 广州青能健日用品有限公司 | Biological environment-friendly anti-oxidation itching-relieving bath foam and preparation method thereof |
| CN102416041A (en) * | 2011-12-13 | 2012-04-18 | 成都默森医药开发有限公司 | Antibacterial and anti-inflammatory traditional Chinese medicine composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 广西象州县一丹生物技术有限公司: "易丹医坊黑皂焕颜洁肤露", 《HTTP://125.35.6.80:8080/FTBA/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=201506261607399EPQL&NID=201506261607399EPQL》 * |
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