CN104997662B - A kind of composition for suppressing bacterial plaque and its application - Google Patents
A kind of composition for suppressing bacterial plaque and its application Download PDFInfo
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- CN104997662B CN104997662B CN201510334169.5A CN201510334169A CN104997662B CN 104997662 B CN104997662 B CN 104997662B CN 201510334169 A CN201510334169 A CN 201510334169A CN 104997662 B CN104997662 B CN 104997662B
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- 230000001580 bacterial effect Effects 0.000 title claims abstract description 21
- 239000000203 mixture Substances 0.000 title abstract description 13
- 229940034610 toothpaste Drugs 0.000 claims abstract description 28
- 239000000606 toothpaste Substances 0.000 claims abstract description 28
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 16
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 16
- 241001330002 Bambuseae Species 0.000 claims abstract description 16
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 16
- 239000011425 bamboo Substances 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 229920001577 copolymer Polymers 0.000 claims abstract description 14
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 14
- 239000011746 zinc citrate Substances 0.000 claims abstract description 14
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 14
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 229960004029 silicic acid Drugs 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000000470 constituent Substances 0.000 claims description 7
- RRLOOYQHUHGIRJ-UHFFFAOYSA-M sodium;ethyl sulfate Chemical compound [Na+].CCOS([O-])(=O)=O RRLOOYQHUHGIRJ-UHFFFAOYSA-M 0.000 claims description 7
- 239000004088 foaming agent Substances 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 235000003599 food sweetener Nutrition 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- -1 stevioside glycosides Chemical class 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 150000005846 sugar alcohols Polymers 0.000 claims description 5
- 239000003765 sweetening agent Substances 0.000 claims description 5
- 241000206575 Chondrus crispus Species 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 229960003563 calcium carbonate Drugs 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000012071 phase Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- RUWKZSPFMDVLRC-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;zinc Chemical compound [Zn].OC(=O)CC(O)(C(O)=O)CC(O)=O RUWKZSPFMDVLRC-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 244000269722 Thea sinensis Species 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 12
- 208000028169 periodontal disease Diseases 0.000 abstract description 6
- 208000010641 Tooth disease Diseases 0.000 abstract description 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 238000009395 breeding Methods 0.000 abstract description 2
- 230000001488 breeding effect Effects 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 210000004872 soft tissue Anatomy 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 229960003500 triclosan Drugs 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 1
- HHEHWCIYDICHCG-ODZAUARKSA-N (z)-but-2-enedioic acid;methoxyethene Chemical compound COC=C.OC(=O)\C=C/C(O)=O HHEHWCIYDICHCG-ODZAUARKSA-N 0.000 description 1
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 description 1
- 241000432824 Asparagus densiflorus Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000605986 Fusobacterium nucleatum Species 0.000 description 1
- 206010018275 Gingival atrophy Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 1
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 1
- 241000605894 Porphyromonas Species 0.000 description 1
- 241001135221 Prevotella intermedia Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- 230000001775 anti-pathogenic effect Effects 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
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- 235000013361 beverage Nutrition 0.000 description 1
- 230000035587 bioadhesion Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
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- 238000004140 cleaning Methods 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000008125 glucin Substances 0.000 description 1
- 239000003845 household chemical Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention relates to a kind of composition, more particularly to a kind of composition for suppressing bacterial plaque and its application, bamboo salt and zinc citrate, methyl vinyl ether maleic acid anhydride copolymer are compounded, can be with Synergistic, persistently suppress harmful microbe growth, breeding in oral cavity, suppress the generation of bacterial plaque.Toothpaste prepared by the present invention, it can form film in hard and soft tissue surface in oral cavity after being brushed teeth using it, slowly release zinc ion, kill the various pathogenic bacteria for causing carious tooth and periodontal disease, suppress the generation of bacterial plaque, and it is nontoxic to human body.
Description
Technical field
The present invention relates to a kind of composition, more particularly to a kind of composition for suppressing bacterial plaque and its application, belong to household chemicals field.
Background technology
Oral health is the important component of whole body health, can directly or indirectly influence whole body health, wherein dental caries
Tooth and periodontal disease are the two kinds of most common diseases to be damaged to China's resident's oral health.Carious tooth is commonly called as decaying tooth, and is danger
The most common disease of victimization class oral health, it is due to production acid after the carbohydrate in the cariogenic bacteria decomposition swill in oral cavity, makes
Into facing demineralization, cavity is ultimately formed；Periodontal disease is only second to carious tooth, is to endanger the healthy second largest disease of Human Oral Cavity, tooth
All diseases mainly exist in the form of inflammation, show as the inflammation of periodontium and the destruction of supporting tissue, Early manifestation is tooth
Oulorrhagia, later stage gradually develop into gingival atrophy, absorption of alveolar bone, oral pocket etc..
The initiation factor that carious tooth and periodontal disease occur all is bacterial plaque.Bacterial plaque is that one kind is attached to tooth, gum etc.
The congeries of a large amount of bacteriums at position, being one includes the Multiple components groups such as membrane structure, bacterium, bacterium metabolite, swill
Into it is relatively independent and also closing system.Tooth paste product on the market acts on mainly by physical friction and removes bacterial plaque at present,
The generation of bacterial plaque can not effectively be suppressed, after a few hours of brushing teeth, remaining harmful bacteria can be after the cleaning in oral cavity facing
On adhere to again, gather to form new bacterial plaque.Although some tooth paste products contain antipathogenic composition, but can not be in mouth after brushing teeth
Effectively stored in chamber, the effect for suppressing bacterial plaque generation can not be played.
The content of the invention
The present invention is directed to above-mentioned the shortcomings of the prior art, there is provided a kind of composition for suppressing bacterial plaque and its application.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of composition for suppressing bacterial plaque, including bamboo salt, lemon
Lemon acid zinc and methyl vinyl ether-maleic acid copolymer, its composition are calculated as (0.1~10) by weight：(0.1~1)：(1~20).
Second object of the present invention is to provide a kind of application of composition described above in toothpaste, mouthwash field.
Third object of the present invention is to provide a kind of toothpaste prepared using above-mentioned composition, and its constituent is by weight
Amount number is calculated as：Rubbing agent 20.0~60.0%, foaming agent 1.6~3.0%, NMF 20.0~70.0%, thickener 0.5~
2.0%th, essence 0.5~2.0%, sweetener 0.1~0.8%, methyl vinyl ether-maleic acid copolymer 0.1~2.0%,
Bamboo salt 0.01~1.0% and zinc citrate 0.01~0.1%, remaining is water.
Wherein, described rubbing agent be hydrated silica, calcium carbonate, calcium phosphate dibasic anhydrous or dicalcium phosphate dihydrate one kind or
Two or more mixing.
Described foaming agent is one kind of laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine or potassium lauroyl sarcosine
Or two or more mixing.
Described NMF is one or more kinds of mixing of sorbierite, propane diols, glycerine, polyethylene glycol or xylitol.
Described thickener is cellulose gum, HPG, carragheen, xanthans, hydroxyethyl cellulose or card ripple
One or more kinds of mixing of nurse.
Described sweetener is one or more kinds of mixing of saccharin sodium, aspartame or stevioside glycosides.
Fourth object of the present invention is to provide a kind of preparation method of toothpaste described above, and thickener is distributed into guarantor
Polynary alcohol phase is formed in humectant, sweetener, bamboo salt are dissolved in water and NMF and form aqueous phase, aqueous phase and polyalcohol are mixed
Homogeneous is ground afterwards 5 minutes, obtain homogeneous glue；Then rubbing agent, zinc citrate and methyl vinyl ether-maleic acid is added to be total to
Polymers, grinding homogeneous 20 minutes；Foaming agent is added, is stirred under vacuum 10 minutes, adds essence, is closed after being stirred under vacuum 10 minutes
Stirring, vacuum breaker, filling after inspection by sampling is qualified is toothpaste finished product.
The beneficial effects of the present invention are：
Bamboo salt antiinflammation is obvious, and oral cavity flora will not be caused to lack of proper care, and long-term use will not damage to oral cavity；
Zinc citrate as common zinc enhancer, be usually used in nutraceutical with beverage, it is safe；Methyl vinyl ether-Malaysia
The macromolecular structure of acid anhydride copolymer has powerful bioadhesion function, can in oral cavity hard and soft tissue surface formed it is thin
Film.The present invention compounds bamboo salt and zinc citrate, methyl vinyl ether-maleic acid copolymer, methyl vinyl ether-Malaysia
Zinc citrate can be wrapped up and form film by acid anhydride copolymer is adhered to tooth, gingival surface, slowly releases in the oral cavity
Zinc ion is released, the various pathogenic bacteria for causing carious tooth and periodontal disease is killed, suppresses the generation of bacterial plaque.Bamboo salt small molecule with from
The form stable of sub-key is extended and made by the sustained release formed after methyl vinyl ether-copolymer-maleic anhydride parcel zinc citrate
With the time, increase operation rate.Three's Synergistic, persistently suppress harmful microbe growth, breeding in oral cavity, suppress bacterial plaque
Generation, it is nontoxic to human body.
Embodiment
The principle and feature of the present invention are described below in conjunction with example, the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the present invention.
Embodiment 1
A kind of toothpaste for suppressing bacterial plaque, its constituent are calculated by weight as：Hydrated silica 25%, laruyl alcohol sulfuric acid
Ester sodium 2.5%, sorbierite 50%, glycerine 8%, cellulose gum 0.6%, essence 1.0%, saccharin sodium 0.2%, methyl ethylene
Ether-copolymer-maleic anhydride 0.2%, bamboo salt 0.01% and zinc citrate 0.1%, remaining is water.
The preparation method of above-mentioned toothpaste is：Cellulose gum is distributed in glycerine, saccharin sodium, bamboo salt are dissolved in water and sorb
In alcohol, grind homogeneous 5 minutes after aqueous phase and polyalcohol are mixed, obtain homogeneous glue；Then hydrated silica, citric acid are added
Zinc and methyl vinyl ether-maleic acid copolymer, grinding homogeneous 20 minutes；Laruyl alcohol sodium sulfovinate is added, is stirred under vacuum
10 minutes, essence is added, stirring is closed after being stirred under vacuum 10 minutes, vacuum breaker, filling after inspection by sampling is qualified is toothpaste finished product.
Embodiment 2
A kind of toothpaste for suppressing bacterial plaque, its constituent are calculated by weight as：Hydrated silica 5%, calcium carbonate 35%,
Laruyl alcohol sodium sulfovinate 2.5%, sorbierite 25%, glycerine 10%, xylitol 1%, xanthans 0.6%, cellulose gum 0.6%,
Essence 1.8%, saccharin sodium 0.4%, methyl vinyl ether-maleic acid copolymer 1.0%, bamboo salt 0.5% and zinc citrate
0.01%, remaining is water.
The preparation method of above-mentioned toothpaste is：Xanthans, cellulose gum are distributed in glycerine, by xylitol, saccharin sodium, bamboo
Salt is dissolved in water and sorbierite, is ground homogeneous 5 minutes after aqueous phase and polyalcohol are mixed, is obtained homogeneous glue；Then add
Hydrated silica, calcium carbonate, zinc citrate and methyl vinyl ether-maleic acid copolymer, grinding homogeneous 20 minutes；Add the moon
Cinnamic alcohol sodium sulfovinate, it is stirred under vacuum 10 minutes, adds essence, stirring, vacuum breaker, inspection by sampling is closed after being stirred under vacuum 10 minutes
Filling after qualified is toothpaste finished product.
Embodiment 3
A kind of toothpaste for suppressing bacterial plaque, its constituent are calculated by weight as：Hydrated silica 10%, hydrogen phosphate dihydrate
Calcium 50%, Cocoamidopropyl betaine 1.6%, sorbierite 10%, glycerine 10%, propane diols 1%, HPG
1.0%th, carragheen 1.0%, essence 0.5%, aspartame 0.8%, methyl vinyl ether-maleic acid copolymer 2.0%, bamboo
Salt 1.0% and zinc citrate 0.01%, remaining is water.
The preparation method of above-mentioned toothpaste is：HPG, carragheen are distributed in glycerine, by propane diols, asparagus fern
Glucin, bamboo salt are dissolved in water and sorbierite, are ground homogeneous 5 minutes after aqueous phase and polyalcohol are mixed, are obtained homogeneous glue；So
Hydrated silica, calcium phosphate dibasic anhydrous, zinc citrate and methyl vinyl ether-maleic acid copolymer are added afterwards, grind homogeneous 20
Minute；Cocoamidopropyl betaine is added, is stirred under vacuum 10 minutes, adds essence, closes and stirs after being stirred under vacuum 10 minutes
Mix, vacuum breaker, filling after inspection by sampling is qualified is toothpaste finished product.
The antibacterial ring test of toothpaste
First, the bacteriostasis shown using the bacteriostatic agent in toothpaste after AGP test forms various concentrations gradient, is led to
Cross antibacterial ring size size and judge whether it has bacteriostasis.Test strain includes the common bacteria for causing carious tooth and periodontal disease：Tooth
Gum Detection of Porphyromonas, Fusobacterium nucleatum, Prevotella intermedia, streptococcus mutans, actinobacillus actinomycetem comitans and Bacillus acidi lactici.
2nd, antibacterial ring test is divided into three groups, is respectively：
1st, test group toothpaste：Toothpaste made from the embodiment of the present invention 1；
2nd, negative control group toothpaste：Its constituent is calculated by weight as：Hydrated silica 25%, laruyl alcohol sodium sulfovinate
2.5%th, sorbierite 50%, glycerine 8%, cellulose gum 0.6%, essence 1.0%, saccharin sodium 0.2%, remaining is water；
3rd, positive controls toothpaste：Its constituent is calculated by weight as：Hydrated silica 25%, laruyl alcohol sodium sulfovinate
2.5%th, sorbierite 50%, glycerine 8%, cellulose gum 0.6%, essence 1.0%, saccharin sodium 0.2%, triclosan 0.3%, remaining is water.
Wherein, triclosan has different degrees of suppression to a variety of gram-positive bacterias and negative bacterium, fungi and killed and makees
With, can effectively suppress the formation of bacterial plaque, be commonly used to the treatment of gingivitis and periodontitis, the application in medicated toothpaste also compared with
Generally, but because its existing safety issue causes query.
3rd, the judgement of bacteriostasis：
Inhibition zone diameter is more than 7mm, and the antibacterial ring size of test group is noticeably greater than negative control group, has been judged to bacteriostasis；
Inhibition zone diameter is less than or equal to 7mm, is judged to no bacteriostasis.Antibacterial ring size result of the test is shown in Table 1.
Table 1
As can be seen from Table 1, the fungistatic effect of test group toothpaste is suitable and bright with the fungistatic effect of positive controls toothpaste
It is aobvious to be better than negative control group toothpaste, show that bamboo salt can be replaced with zinc citrate, methyl vinyl ether-maleic acid copolymer compounding
There is the triclosan of potential safety hazard in generation, there is good inhibitory action, and safety and environmental protection to oral cavity pathogen.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (2)
1. a kind of toothpaste for suppressing bacterial plaque, it is characterised in that its constituent is calculated by weight as：Rubbing agent 20.0~
60.0%th, foaming agent 1.6~3.0%, NMF 20.0~70.0%, thickener 0.5~2.0%, essence 0.5~2.0%, sweet tea
Taste agent 0.1~0.8%, methyl vinyl ether-maleic acid copolymer 0.1~2.0%, bamboo salt 0.01~1.0% and citric acid
Zinc 0.01~0.1%, remaining is water；
Described rubbing agent is the one or more of hydrated silica, calcium carbonate, calcium phosphate dibasic anhydrous or dicalcium phosphate dihydrate
Mixing；
Described foaming agent is laruyl alcohol sodium sulfovinate, one kind of Cocoamidopropyl betaine or potassium lauroyl sarcosine or two
Kind is mixed above；
Described NMF is one or more kinds of mixing of sorbierite, propane diols, glycerine, polyethylene glycol or xylitol；
Described thickener is cellulose gum, HPG, carragheen, xanthans, hydroxyethyl cellulose or carbomer
One or more mixing；
Described sweetener is one or more kinds of mixing of saccharin sodium, aspartame or stevioside glycosides.
2. the preparation method of toothpaste described in a kind of claim 1, it is characterised in that it is more that thickener is distributed to formation in NMF
First alcohol phase, sweetener, bamboo salt are dissolved in water and NMF and form aqueous phase, homogeneous 5 is ground after aqueous phase and polyalcohol are mixed
Minute, obtain homogeneous glue；Then rubbing agent, zinc citrate and methyl vinyl ether-maleic acid copolymer are added, grinding is equal
Matter 20 minutes；Foaming agent is added, is stirred under vacuum 10 minutes, adds essence, stirring is closed after being stirred under vacuum 10 minutes, is broken true
Sky, filling after inspection by sampling is qualified is toothpaste finished product.
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| CN107362064B (en) * | 2017-07-27 | 2018-05-11 | 安徽省银锂子生物科技发展有限公司 | It is a kind of can effectively antibacterial, brilliant white, the toothpaste of repairing dental enamel |
| CN107648062A (en) * | 2017-09-18 | 2018-02-02 | 广州星业科技股份有限公司 | A kind of amino acid toothpaste of no added laruyl alcohol sodium sulfovinate and preparation method thereof |
| CN113827506B (en) * | 2021-10-20 | 2023-06-09 | 安徽克菱保健科技有限公司 | An oral care mousse for antibacterial, anti-caries, whitening teeth, anti-allergic and deodorizing |
| CN115998651B (en) * | 2022-06-17 | 2024-04-19 | 广州舒客实业有限公司 | Composition for removing breath and preventing dental plaque comprising persimmon extract and oral care product containing same |
| CN115944572A (en) * | 2023-02-07 | 2023-04-11 | 湖南天华医药生物科技有限公司 | Toothpaste based on nutgall extract and preparation method thereof |
| CN118105324B (en) * | 2024-03-05 | 2024-07-26 | 广州冰泉化妆品科技有限公司 | Whitening antibacterial toothpaste and preparation method thereof |
| CN117982361A (en) * | 2024-04-03 | 2024-05-07 | 广州悦创实业有限公司 | Submicron whitening toothpaste for inhibiting dental plaque and preparation method thereof |
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