CN104971420B - A kind of heart situ perfusion conduit - Google Patents

Abstract

The invention discloses a heart perfusion catheter in situ, which belongs to the technical field of cardiac treatment devices. The perfusion catheter includes an outer coating layer and two inner tubes inside the outer coating layer, and the two inner tubes are covered by the outer coating layer. Its overall shape is composed of a straight section and a hook section, the hook section is composed of an arc section and a straight section, and the arc section is connected with the straight section; one of the two inner tubes corresponding to the straight section is The end is closed and the side is open, and the other is the end and the side is open. The opening of the inner tube penetrates the outer cladding layer. The cardiac in situ perfusion catheter of the present invention is used in conjunction with a hydraulic pump, a physiological signal collector, a signal discriminator and an infusion pump), the inner tube with an open end transmits a pressure signal to the physiological signal collector through the open end, and the pressure signal passes through the signal discriminator After processing, start and stop signals are sent to the infusion pump, and the infusion pump delivers liquid to the heart through the inner tube with the side opening. The invention is helpful to realize long-term cardiac targeted perfusion and has high safety.

Description

A Catheter for In Situ Cardiac Perfusion

technical field

The invention relates to a perfusion catheter, in particular to a catheter applied to cardiac in situ perfusion, and belongs to the technical field of medical devices.

Background technique

Ischemic heart disease is a common disease that seriously threatens human health. Current conventional treatments have limited curative effect. Stem cell transplantation and cytokine infusion have shown great potential in the treatment of ischemic heart disease, but it is necessary for therapeutic drugs to play a therapeutic role in situ in the heart to avoid uptake and utilization of peripheral non-target tissues.

At present, a number of clinical trials on the treatment of ischemic heart disease with cytokine drugs have been carried out at home and abroad. These two methods are combined with subcutaneous injection for continuous administration. Due to the high price of cytokine protein preparations, the half-life in vivo is usually very short (several minutes), and when administered intravenously or subcutaneously, most of them have been degraded or combined with non-target cells when they reach the target organ through the absorption cycle; while the first dose is administered through the coronary artery Drugs infused within the heart are quickly washed out to extracardiac tissues along with the blood flow. Therefore, the problem of the current drug administration method is that the therapeutic effect on the target organ of the heart is not obvious. , Body fluid penetration, edema performance is obvious. Finding a new route of administration is of great significance to improving the therapeutic effect.

At present, the existing route of drug administration for heart disease is to use a microcatheter or a balloon to enter the target vessel through the coronary artery combined with continuous intravenous or subcutaneous administration. The problems with this method are: ①. However, the drug quickly spreads to the peripheral tissue due to blood flow washing; ②. The catheter cannot be left in the coronary artery for a long time.

The intracoronary perfusion method is implemented according to the coronary intervention technique, guiding the catheter into the coronary artery, the guide wire enters the target blood vessel along the guiding catheter, and then releases the microcatheter or balloon to the target position along the guidewire, and finally injects the fluid along the microcatheter target vessel. Since the guiding catheter needs to enter the coronary artery, it is easy to damage the blood vessel or the catheter is left in the coronary artery for a long time to cause thrombosis in the coronary artery.

Contents of the invention

In view of this, the present invention provides a cardiac perfusion catheter in situ, which is not easy to pop into the coronary artery opening and has high safety, which is helpful to realize long-term cardiac targeted perfusion.

A cardiac perfusion catheter in situ, the perfusion catheter includes an outer cladding layer and two inner tubes inside the outer cladding layer, the outer surfaces of the two inner tubes are completely covered by the outer cladding layer, and its overall shape It is composed of a straight section and a hook section. The hook section is composed of an arc section and a straight section. The arc section connects with the straight section; The side is open, the other is an end opening, the opening of the side opening inner tube runs through the outer cladding layer, and the ends of the two inner tubes corresponding to the straight section are open structures.

Further, the outer cladding layer is vulcanized by polyethylene material and steel wire mesh, the polyethylene material determines the hardness, shape and friction with the intima of the blood vessel, and the steel wire mesh forms the skeleton of the perfusion catheter, so that the perfusion catheter The lumen will not collapse and has anti-fracture effect.

Further, the length of the straight portion of the perfusion catheter is 105-110 cm, and the outer diameter of the catheter is 5F-7F.

Further, the arc radius of the arc section of the hook portion of the perfusion catheter is 3-5mm, and the length of the straight section is 8-12mm.

Working principle: the cardiac in situ perfusion catheter of the present invention is used in conjunction with a physiological signal collector, a signal discriminator and an infusion pump. The side opening on the straight section of the part corresponds to the position of the coronary sinus ostium, the two inner tubes corresponding to the straight section are respectively connected to the physiological signal collector and the infusion pump through the infusion tube, and the inner tube with the end opening on the straight section of the hook part The pressure at the position is sensed through the opening, and the pressure signal is transmitted to the physiological signal collector. The pressure signal is processed by the signal discriminator to obtain the diastolic time course. The signal discriminator controls the infusion pump to start according to the rule of the diastolic time course. Fluid is delivered to the heart through an inner tube that opens on the side.

Beneficial effect:

1. The end of the catheter of the present invention is straight and does not have an upwardly tilted hook, which prevents the catheter from bouncing into the coronary artery opening during the release process, which can prevent damage and has high safety.

2. The interior of the present invention adopts a double-chamber structure. The catheter only needs to be released at the ostium of the coronary artery and does not enter the coronary artery. The input liquid enters the ostium of the sinus through the chamber of the side opening, which can avoid damage to blood vessels or Long-term indwelling catheters in coronary arteries can cause intracoronary thrombosis.

Description of drawings

Fig. 1 is the outline structure schematic diagram of the present invention;

Fig. 2 is the structural representation of the straight section part of the present invention;

Fig. 3 is a schematic diagram of the application of the present invention.

Among them, 1-outer cladding layer, 2-end opening, 3-inner tube I, 4-side opening, 5-inner tube II, 6-straight part, 7-hook part.

Detailed ways

The present invention will be described in detail below with reference to the accompanying drawings and examples.

As shown in accompanying drawings 1 and 2, the present invention provides a kind of heart in situ perfusion catheter, and described perfusion catheter comprises outer cladding layer 1 and inner tube I3 and inner tube II5 inside the outer cladding layer, the outer cladding layer It is made of polyethylene material and steel wire mesh vulcanized; the outer surface of the inner pipe I3 and inner pipe II5 is completely covered by the outer cladding layer 1, and its overall shape is composed of a straight section 6 and a hook section 7. The hook part 7 is composed of an arc segment and a straight segment, and the arc segment connects with the straight segment 6; the end of the inner tube I3 corresponding to the straight segment is closed and has a side opening 4, and the end of the inner tube II5 is open , the side opening of the inner tube I3 runs through the outer cladding layer 1, and the ends of the inner tube I3 and the inner tube II5 corresponding to the straight section are open structures.

The length of the straight section of the perfusion catheter is 110cm, the outer diameter of the catheter is 6F, the arc radius of the arc section of the hook part of the perfusion catheter is 4mm, and the length of the straight section is 10mm.

Working principle: the cardiac in situ perfusion catheter of the present invention is used in conjunction with a physiological signal collector, a signal discriminator and an infusion pump. Corresponding parts of the heart, the end of the straight section of the hook part 7 corresponds to the sinus ostium, the inner tube II 5 transmits the pressure signal to the physiological signal collector through the open end, the pressure signal is processed by the signal discriminator, and the signal discriminator detects a pressure wave unit When the position in the center (corresponding to the diastolic period of the heart), a start signal is sent to the infusion pump, and the fluid is delivered to the heart through the side opening of the inner tube I3; before the rising branch of the next pressure wave (corresponding to the systolic period of the heart), a stop Signal.

To sum up, the above are only preferred embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (4)

1. A heart perfusion catheter in situ, characterized in that the perfusion catheter comprises an outer coating and two inner tubes inside the outer coating, the outer surfaces of the two inner tubes are completely covered by the outer coating. Covering, its overall shape is composed of a straight section and a hook section, the hook section is composed of an arc section and a straight section, and the arc section is connected with the straight section; the two inner rods corresponding to the straight section One of the tubes is closed at the end and open at the side, and the other is open at the end. The opening of the inner tube with the side opening runs through the outer cladding layer, and the ends of the two inner tubes corresponding to the straight section are open ends. 2. The cardiac in situ perfusion catheter according to claim 1, wherein the outer cladding layer is vulcanized from polyethylene material and steel wire mesh. 3. The cardiac in situ perfusion catheter according to claim 1 or 2, wherein the length of the straight part of the perfusion catheter is 105-110cm, and the outer diameter of the perfusion catheter is 5F-7F. 4. The cardiac in situ perfusion catheter according to claim 1 or 2, characterized in that, the arc radius of the arc section of the hook portion of the perfusion catheter is 3-5mm, and the length of the straight section is 8-12mm.