CN104958525A - Traditional Chinese medicine composition for treating chronic infectious arthritis and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating chronic infectious arthritis and preparation method of traditional Chinese medicine composition Download PDFInfo
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- 239000003814 drug Substances 0.000 title 2
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- 238000002360 preparation method Methods 0.000 title 1
- 201000001223 septic arthritis Diseases 0.000 title 1
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating chronic infectious arthritis. The traditional Chinese medicine composition is prepared from the following raw materials: astragalus membranaceus, codonopsis pilosula, coptis chinensis, rhizoma curculiginis, semen cuscutae, achyranthes aspera, fructus psoraleae, Chinese yam, rhizoma anemarrhenae, rhizoma atractylodis, spina gleditsiae, lycopodium clavatum, liquidambar formosana hance, asarum, kadsura pepper stem and liquorice. The traditional Chinese medicine composition has significant treatment advantages of being good in treatment effect and not easy to recur, is capable of treating both symptoms and root causes, and combining conditioning with treatment, and also has the technical advantages of being simple in preparation technology, stable in medicine effect, high in universality, and easy to popularize and apply.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of rheumatoid arthritis.
Background technology
Rheumatoid arthritis is a kind of common based on joint and periarticular non-infectious inflammation, can cause the chronic generalized autoimmune disease of joint severe deformities.
The traditional Chinese medical science is thought: rheumatoid arthritis feelings are repeatedly touching, and its course of disease is long, and its pathological factor is empty from the beginning of being mainly natural endowment element, caused by liver and kidney deficiency, YANG QI deficiency, interspaces of skin and muscles being loose, weakened defensive QI, so that wind, cold, wet heresy is taken advantage of a weak point, multiple abscess meridians, joint, hinder QI-blood circulation and fall ill.Kidney governing bones, liver governing tendons, muscles and bones joint all relies Liver and kidney essence and blood to moisten foster.Evil objective muscles and bones, muscle damage liver, bone injury kidney, lesions of liver and kidney then muscles and bones mistake is supported, and muscle does not fill, and causes joint contracture dragging pain, joint stuffiness, very then causes flesh to wither, Jinsuo, bone damage, joint deformity is stiff, the function serious hindrance such as difficult of taking action.Spleen governing muscles, transmitting and distributing the fluids, raw in insufficiency of the spleen then phlegm-damp, damp-phlegm is tied mutually, wreaks havoc and haunts, and flows that excessive muscle passages through which vital energy circulates visible body weight joint is swollen, hydrarthrosis etc., so Liver and kidney spleen deficiency of qi and blood is the main intrinsic factor of primary disease.Again because the state of an illness is touching, recurrent exerbation, must have exopathogen priming for it, the invasion and attack repeatedly of the heresy that wind and cold is damp and hot, go deep into channel tunnel, bone joint, passages through which vital energy circulates is unfavorable forms blood stasis, and turbid damp viscous forms phlegm retention, and the expectorant stasis of blood hands over resistance then to keep joint, stasis blocking meridians, form the stiff swelling of joint, deformity, with the passing of time difficult multiple.Therefore say primary disease with liver deficiency of spleen and stomach for it, the wind and cold wet hot phlegm stasis of blood is its mark, unfavorable through BI-syndrome involved the blood vessels resistance, qi and blood stagnation is obstructed be its pathomechanism, pathological changes mechanism can be summarized as " void, heresy, the stasis of blood " three.
Because rheumatoid arthritis is obstinate, the course of disease is permanent, the cause of disease with liver deficiency of spleen and stomach for disease this, the wind and cold wet hot phlegm stasis of blood is its mark, unfavorable through BI-syndrome involved the blood vessels resistance, qi and blood stagnation is obstructed is its pathology, therefore treatment is upper based on nourishing the liver and kidney, invigorating qi and benefiting blood, harmonizing the spleen and stomach, help, blood stasis dispelling blood turbid with heat clearing away poison, damp eliminating, reduce phlegm turbid, search wind and pick heresy, declare the principle for the treatment of of numbness analgesic therapy.
Chinese patent 201110370097.1 discloses a kind of Chinese medicine for the treatment of rheumatoid arthritis, this Chinese medicine comprises following raw material: Cortex Acanthopancis, Caulis Akebiae, Scorpio, thorn fossilia dentis mastodi, Radix Achyranthis Bidentatae, Fructus Lycii, Caulis Spatholobi, Herba Epimedii, Radix Saposhnikoviae, Herba Lycopodii, Cortex erythrinae, Stigma Croci, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Clematidis, Semen Strychni and Rhizoma Atractylodis, and this Chinese medicine has the effect for the treatment of rheumatoid arthritis.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of rheumatoid arthritis, this Chinese medicine composition has effect of blood circulation promoting and blood stasis dispelling, mass dissipating and swelling eliminating, anti-inflammatory analgesic, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight:
Radix Astragali 6-15 part, Radix Codonopsis 9-30 part, Rhizoma Coptidis 1-5 part, Rhizoma Curculiginis 3-9 part, Semen Cuscutae 6-12 part, Radix Achyranthis 9-15 part, Fructus Psoraleae 6-9 part, Rhizoma Dioscoreae 3-15 part, Rhizoma Anemarrhenae 6-12 part, Rhizoma Atractylodis 3-9 part, Spina Gleditsiae 3-9 part, Herba Lycopodii 3-12 part, Fructus Liquidambaris 5-9 part, Herba Asari 1-3 part, Caulis Piperis Kadsurae 6-12 part and Radix Glycyrrhizae 1-10 part.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 6 parts, Radix Codonopsis 9 parts, Rhizoma Coptidis 1 part, Rhizoma Curculiginis 3 parts, Semen Cuscutae 6 parts, Radix Achyranthis 9 parts, Fructus Psoraleae 6 parts, Rhizoma Dioscoreae 3 parts, the Rhizoma Anemarrhenae 6 parts, Rhizoma Atractylodis 3 parts, Spina Gleditsiae 3 parts, Herba Lycopodii 3 parts, Fructus Liquidambaris 5 parts, Herba Asari 1 part, Caulis Piperis Kadsurae 6 parts and 1 part, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 30 parts, Rhizoma Coptidis 5 parts, Rhizoma Curculiginis 9 parts, Semen Cuscutae 12 parts, Radix Achyranthis 15 parts, Fructus Psoraleae 9 parts, Rhizoma Dioscoreae 15 parts, the Rhizoma Anemarrhenae 12 parts, Rhizoma Atractylodis 9 parts, Spina Gleditsiae 9 parts, Herba Lycopodii 12 parts, Fructus Liquidambaris 9 parts, Herba Asari 3 parts, Caulis Piperis Kadsurae 12 parts and 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Codonopsis 20 parts, Rhizoma Coptidis 3 parts, Rhizoma Curculiginis 6 parts, Semen Cuscutae 9 parts, Radix Achyranthis 12 parts, Fructus Psoraleae 7 parts, Rhizoma Dioscoreae 9 parts, the Rhizoma Anemarrhenae 9 parts, Rhizoma Atractylodis 6 parts, Spina Gleditsiae 6 parts, Herba Lycopodii 8 parts, Fructus Liquidambaris 7 parts, Herba Asari 2 parts, Caulis Piperis Kadsurae 9 parts and 5 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is oral formulations.
Again further, described oral formulations is tablet, capsule, drop pill, granule, powder or oral liquid.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
Step one: take the Radix Astragali, Radix Codonopsis, Rhizoma Coptidis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, Fructus Psoraleae, Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Herba Asari, Caulis Piperis Kadsurae and Radix Glycyrrhizae;
Step 2: the Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Herba Asari are pulverized respectively, the concentration adding 7-10 times of weight after mixing is the ethanol of 60-70%, soaks 6-12 hour, and backflow decocts, extract 1-3 time, each 2-4 hour, filters, and retains filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55-60 DEG C of relative density be the concentrated solution of 1.20-1.25, for subsequent use;
Step 3: Rhizoma Coptidis, Fructus Psoraleae, Rhizoma Dioscoreae, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Caulis Piperis Kadsurae and Radix Glycyrrhizae are pulverized respectively, with the purified water adding 6-8 times of weight after the filtering residue mixing of step 2, backflow decocts 1-3 time, each 1-3 hour, filter, merging filtrate, being concentrated into 55-60 DEG C of relative density is the concentrated solution of 1.20-1.25, for subsequent use;
Step 4: merged by concentrated solution obtained in step 2 and step 3, mix homogeneously, continuing to be evaporated to 55-60 DEG C of relative density is the thick paste of 1.30-1.35, obtains Chinese medicine composition of the present invention.
Source, the nature and flavor of the present invention's component used, return through and effect:
The Radix Astragali: this product is the root of leguminous plant Radix Hedysari multijugi; Sweet in the mouth, warm in nature; GUIXIN, lung, spleen, kidney channel; Invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.
Radix Codonopsis: this product is the dry root of Campanulaceae Radix Codonopsis; Sweet in the mouth, property is put down; Return spleen, lung meridian; Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis; Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
Rhizoma Curculiginis: this product is the dry rhizome of amrallid Rhizoma Curculiginis; Acrid in the mouth, hot in nature; Return kidney,liver,spleen warp; Kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant; Sweet in the mouth, warm in nature; Return liver,kidney,spleen warp; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
Radix Achyranthis: for Amaranthaceae Achyranthes plant soil Radix Achyranthis Bidentatae is used as medicine with root (Radix Achyranthis) or herb (Radix achyranthis asperae (Herba Achyranthis Asperae)); Mildly bitter flavor, cool in nature; Return liver, kidney channel; Blood circulation promoting and blood stasis dispelling, eliminating fire and detoxication, inducing diuresis for treating stranguria syndrome.
Fructus Psoraleae: this product is the dry mature fruit of legumes psoraleae; Acrid in the mouth, hardship, warm in nature; Return kidney, spleen channel; Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae; Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.
The Rhizoma Anemarrhenae: this product is the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae; Bitter in the mouth, sweet, cold in nature; Return lung, stomach, kidney channel; Clearing away heat-fire, promotes the production of body fluid and moisturizes.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC.; Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Spina Gleditsiae: this product is the dry Spina jujubae of leguminous plant Fructus Gleditsia; Acrid in the mouth, warm in nature; Return liver, stomach warp; Detumescence poison holding, evacuation of pus, parasite killing.
Herba Lycopodii: this product is the dry herb of lycopsid Lycopodium clavatum; Mildly bitter flavor, pungent, warm in nature; Return liver,spleen,kidney warp; Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.
Fructus Liquidambaris: this product is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum; Bitter in the mouth, property is put down; Return liver, kidney channel; Dispelling, collateral-activating, diuretic stimulates the menstrual flow.
Herba Asari: this product is the dry herb of aristolochiaceae plant Herba Asari, Seoul Herba Asari or magnificent Herba Asari; Acrid in the mouth, warm in nature; GUIXIN, lung, kidney channel; Expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.
Caulis Piperis Kadsurae: this product is the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii; Acrid in the mouth, hardship, slightly warm in nature; Return Liver Channel; Wind-damp dispelling, the meridian dredging, stopping numbness pain.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, Chinese medicine composition of the present invention has following technical advantage:
1, shown by clinical trial, Chinese medicine composition of the present invention has significant treatment advantage in treatment rheumatoid arthritis, and the clinical symptoms effect especially for rheumatoid arthritis such as liver deficiency of spleen and stomach, the wind and cold wet hot phlegm stasis of bloods is particularly remarkable.
2, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, and medication effect is better.
3, Chinese medicine composition compatibility science of the present invention, by the synergism between each component, better in curative effect, and in addition, the preparation technology of said composition is simple, is conducive to large-scale production, makes various oral formulations and facilitate patient to take.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1: the preparation of drop pill
The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 6 parts, Radix Codonopsis 9 parts, Rhizoma Coptidis 1 part, Rhizoma Curculiginis 3 parts, Semen Cuscutae 6 parts, Radix Achyranthis 9 parts, Fructus Psoraleae 6 parts, Rhizoma Dioscoreae 3 parts, the Rhizoma Anemarrhenae 6 parts, Rhizoma Atractylodis 3 parts, Spina Gleditsiae 3 parts, Herba Lycopodii 3 parts, Fructus Liquidambaris 5 parts, Herba Asari 1 part, Caulis Piperis Kadsurae 6 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: take the Radix Astragali, Radix Codonopsis, Rhizoma Coptidis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, Fructus Psoraleae, Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Herba Asari, Caulis Piperis Kadsurae and Radix Glycyrrhizae;
Step 2: the Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Herba Asari are pulverized respectively, the concentration adding 7 times of weight after mixing is 60% ethanol, soaks 6 hours, and backflow decocts, extract 2 times, each 2 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be the concentrated solution of 1.20, for subsequent use;
Step 3: Rhizoma Coptidis, Fructus Psoraleae, Rhizoma Dioscoreae, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Caulis Piperis Kadsurae and Radix Glycyrrhizae are pulverized respectively, with the purified water adding 6 times of weight after the filtering residue mixing of step 2, backflow decoction 2 times, each 1 hour, filter, merging filtrate, being concentrated into 55 DEG C of relative densities is the concentrated solution of 1.20, for subsequent use;
Step 4: merged by concentrated solution obtained in step 2 and step 3, mix homogeneously, continuing to be evaporated to 55 DEG C of relative densities is the thick paste of 1.30, obtains the embodiment of the present invention 1 Chinese medicine composition;
Step 5: the thick paste of step 4 is dry, be ground into fine powder, cross No. five sieves, remove thick fine powder, then the water-soluble base gelatin of fine powder weight 6 times is added, mix homogeneously, heating, emulsifying obtains medicinal liquid, put into pill dripping machine and make drop, add the condensed fluid dimethicone of fine powder weight 1/8, obtained pellet, wherein, condensed fluid and substrate are not miscible, after drop pill molding, removing dimethicone, and dry arrangement, carry out quality inspection, after qualified on inspection, packaging, obtains the drop pill of the embodiment of the present invention 1 Chinese medicine composition.
embodiment 2: the preparation of drop pill
The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 30 parts, Rhizoma Coptidis 5 parts, Rhizoma Curculiginis 9 parts, Semen Cuscutae 12 parts, Radix Achyranthis 15 parts, Fructus Psoraleae 9 parts, Rhizoma Dioscoreae 15 parts, the Rhizoma Anemarrhenae 12 parts, Rhizoma Atractylodis 9 parts, Spina Gleditsiae 9 parts, Herba Lycopodii 12 parts, Fructus Liquidambaris 9 parts, Herba Asari 3 parts, Caulis Piperis Kadsurae 12 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3: the preparation of drop pill
The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Codonopsis 20 parts, Rhizoma Coptidis 3 parts, Rhizoma Curculiginis 6 parts, Semen Cuscutae 9 parts, Radix Achyranthis 12 parts, Fructus Psoraleae 7 parts, Rhizoma Dioscoreae 9 parts, the Rhizoma Anemarrhenae 9 parts, Rhizoma Atractylodis 6 parts, Spina Gleditsiae 6 parts, Herba Lycopodii 8 parts, Fructus Liquidambaris 7 parts, Herba Asari 2 parts, Caulis Piperis Kadsurae 9 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 4: the preparation of dispersible tablet
The embodiment of the present invention 4 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 6 parts, Radix Codonopsis 9 parts, Rhizoma Coptidis 1 part, Rhizoma Curculiginis 3 parts, Semen Cuscutae 6 parts, Radix Achyranthis 9 parts, Fructus Psoraleae 6 parts, Rhizoma Dioscoreae 3 parts, the Rhizoma Anemarrhenae 6 parts, Rhizoma Atractylodis 3 parts, Spina Gleditsiae 3 parts, Herba Lycopodii 3 parts, Fructus Liquidambaris 5 parts, Herba Asari 1 part, Caulis Piperis Kadsurae 6 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: take the Radix Astragali, Radix Codonopsis, Rhizoma Coptidis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, Fructus Psoraleae, Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Herba Asari, Caulis Piperis Kadsurae and Radix Glycyrrhizae;
Step 2: the Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Herba Asari are pulverized respectively, the concentration adding 10 times of weight after mixing is 70% ethanol, soaks 12 hours, and backflow decocts, extract 3 times, each 4 hours, filter, retain filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.25, for subsequent use;
Step 3: Rhizoma Coptidis, Fructus Psoraleae, Rhizoma Dioscoreae, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Caulis Piperis Kadsurae and Radix Glycyrrhizae are pulverized respectively, with the purified water adding 8 times of weight after the filtering residue mixing of step 2, backflow decoction 3 times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.25, for subsequent use;
Step 4: merged by concentrated solution obtained in step 2 and step 3, mix homogeneously, continuing to be evaporated to 60 DEG C of relative densities is the thick paste of 1.35, obtains the embodiment of the present invention 4 Chinese medicine composition;
Step 5: the thick paste of step 4 is dry, be ground into fine powder, cross 100 mesh sieves, add filler calcium sulfate, mix homogeneously, then add disintegrating agent 5%PVP-K30 ethanol solution to granulate in right amount, drying, then add binding agent microcrystalline Cellulose, the amount ratio of fine powder and filler, disintegrating agent, binding agent is 1:0.8:0.5:0.5, tabletting, obtains the dispersible tablet of the embodiment of the present invention 4.
embodiment 5: the preparation of dispersible tablet
The embodiment of the present invention 5 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 30 parts, Rhizoma Coptidis 5 parts, Rhizoma Curculiginis 9 parts, Semen Cuscutae 12 parts, Radix Achyranthis 15 parts, Fructus Psoraleae 9 parts, Rhizoma Dioscoreae 15 parts, the Rhizoma Anemarrhenae 12 parts, Rhizoma Atractylodis 9 parts, Spina Gleditsiae 9 parts, Herba Lycopodii 12 parts, Fructus Liquidambaris 9 parts, Herba Asari 3 parts, Caulis Piperis Kadsurae 12 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
embodiment 6: the preparation of dispersible tablet
The embodiment of the present invention 6 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Codonopsis 20 parts, Rhizoma Coptidis 3 parts, Rhizoma Curculiginis 6 parts, Semen Cuscutae 9 parts, Radix Achyranthis 12 parts, Fructus Psoraleae 7 parts, Rhizoma Dioscoreae 9 parts, the Rhizoma Anemarrhenae 9 parts, Rhizoma Atractylodis 6 parts, Spina Gleditsiae 6 parts, Herba Lycopodii 8 parts, Fructus Liquidambaris 7 parts, Herba Asari 2 parts, Caulis Piperis Kadsurae 9 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
clinical observation on the therapeutic effect
1, case selection: in 400 routine rheumatoid arthritis clinical volunteers patients, male patient 280 example, female patient 120 example, age bracket be 30-70 year, the mean age is 50 years old, and all patients are no difference of science of statistics in sex, age, the course of disease.
2, diagnostic criteria:
(1) Western medicine diagnose standard: 1. morning is stiff; 2. more than 3 or 3 arthroncuss (soft tissue); 3. joints of hand swelling (proximal interphalangeal joint, metacarpophalangeal joints or carpal joint); 4. symmetrical swelling (soft tissue); 5. subcutaneous nodule; 6. serum rheumatoid factor (SRF) is positive; 7. osteoarthrosis X line sheet shows hands or carpal joint aggressivity defect and (or) periarticular osteoporosis.Continue 6 weeks or more, possess 4 in above-listed 7 standards, can diagnostics classes rheumatic arthritis.
(2) tcm diagnosis standard: limbs local swelling, joint cold type of pain, joint stuffiness, or sore spot migration is indefinite, and the pain increased in weather drastic change, pain increase in intensity under coldness, obtains warm alleviation of pain, tastelessness and no thirst or thirsty for hot drink, and pale tongue with white fur, tense pulse or string delay.
3, exclusion standard: meet following wherein 1 person, namely give eliminating: be not 1. inconsistent with inclusive criteria person or merge other rheumatism patient; 2. gestation or women breast-feeding their children, allergic constitution or those who are allergic to this drug, merge intentionally, cerebrovascular, liver, kidney, the severe primary disease such as hemopoietic system, psychotic; 3. not by regulation medication, the infull person of curative effect or data cannot be judged.
4, efficacy assessment standard:
Effective: overall improvement rate >=75% of cardinal symptom sign;
Progressive: overall improvement rate >=50% of cardinal symptom sign;
Effective: overall improvement rate >=30% of cardinal symptom sign;
Invalid: the overall improvement rate < 30% of cardinal symptom sign;
Total effective rate=(effective number+progress number+efficiently individual quantity)/total number of cases × 100%.
5, instructions of taking: 400 patients are divided into 4 groups at random, often organize 100 people, be respectively treatment A group, treatment B group, treatment C group and matched group, the dispersible tablet (0.1g*100 sheet/bottle) that the oral embodiment of the present invention 4 for the treatment of A group prepares, every day 2 times, each 6; The dispersible tablet (0.1g*100 sheet/bottle) that the oral embodiment of the present invention 5 for the treatment of B group prepares, every day 2 times, each 6; The dispersible tablet (0.1g*100 sheet/bottle) that the oral embodiment of the present invention 6 for the treatment of C group prepares, every day 2 times, each 6; Matched group takes the rheumatalgia sheet of commercial type, one time 6,2 times on the one, take 3 months respectively.
6, therapeutic outcome: as shown in table 1.
table 1 therapeutic outcome
This test adopts rheumatalgia sheet as a control group, the main component of rheumatalgia sheet comprises 21 tastes such as Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae, Ramulus Cinnamomi, Herba Taxilli, Radix Clematidis, the Radix Astragali, Radix Aconiti Lateralis Preparata, Cornu Cervi Pantotrichum, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, there is expelling wind and cold, dehumidify active, effect of nourishing the liver and kidney.As shown in Table 1, the obvious effective rate of Chinese medicine composition of the present invention reaches more than 75.0%, total effective rate reaches more than 85.0%, higher than obvious effective rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, visible, the good effect of Chinese medicine composition of the present invention, obvious effective rate is high, can be used as the drug use for the treatment of rheumatoid arthritis.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (7)
1. treat the Chinese medicine composition of rheumatoid arthritis for one kind, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Astragali 6-15 part, Radix Codonopsis 9-30 part, Rhizoma Coptidis 1-5 part, Rhizoma Curculiginis 3-9 part, Semen Cuscutae 6-12 part, Radix Achyranthis 9-15 part, Fructus Psoraleae 6-9 part, Rhizoma Dioscoreae 3-15 part, Rhizoma Anemarrhenae 6-12 part, Rhizoma Atractylodis 3-9 part, Spina Gleditsiae 3-9 part, Herba Lycopodii 3-12 part, Fructus Liquidambaris 5-9 part, Herba Asari 1-3 part, Caulis Piperis Kadsurae 6-12 part and Radix Glycyrrhizae 1-10 part.
2. the Chinese medicine composition for the treatment of rheumatoid arthritis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 6 parts, Radix Codonopsis 9 parts, Rhizoma Coptidis 1 part, Rhizoma Curculiginis 3 parts, Semen Cuscutae 6 parts, Radix Achyranthis 9 parts, Fructus Psoraleae 6 parts, Rhizoma Dioscoreae 3 parts, the Rhizoma Anemarrhenae 6 parts, Rhizoma Atractylodis 3 parts, Spina Gleditsiae 3 parts, Herba Lycopodii 3 parts, Fructus Liquidambaris 5 parts, Herba Asari 1 part, Caulis Piperis Kadsurae 6 parts and 1 part, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of rheumatoid arthritis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 30 parts, Rhizoma Coptidis 5 parts, Rhizoma Curculiginis 9 parts, Semen Cuscutae 12 parts, Radix Achyranthis 15 parts, Fructus Psoraleae 9 parts, Rhizoma Dioscoreae 15 parts, the Rhizoma Anemarrhenae 12 parts, Rhizoma Atractylodis 9 parts, Spina Gleditsiae 9 parts, Herba Lycopodii 12 parts, Fructus Liquidambaris 9 parts, Herba Asari 3 parts, Caulis Piperis Kadsurae 12 parts and 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of rheumatoid arthritis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Codonopsis 20 parts, Rhizoma Coptidis 3 parts, Rhizoma Curculiginis 6 parts, Semen Cuscutae 9 parts, Radix Achyranthis 12 parts, Fructus Psoraleae 7 parts, Rhizoma Dioscoreae 9 parts, the Rhizoma Anemarrhenae 9 parts, Rhizoma Atractylodis 6 parts, Spina Gleditsiae 6 parts, Herba Lycopodii 8 parts, Fructus Liquidambaris 7 parts, Herba Asari 2 parts, Caulis Piperis Kadsurae 9 parts and 5 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment rheumatoid arthritis as described in as arbitrary in claim 1-4, is characterized in that: described Chinese medicine composition is oral formulations.
6. the Chinese medicine composition for the treatment of rheumatoid arthritis as claimed in claim 5, it is characterized in that, described oral formulations is tablet, capsule, drop pill, granule, powder or oral liquid.
7. prepare as arbitrary in claim 1-4 as described in the method for Chinese medicine composition for the treatment of rheumatoid arthritis, it is characterized in that comprising the steps:
Step one: take the Radix Astragali, Radix Codonopsis, Rhizoma Coptidis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, Fructus Psoraleae, Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Herba Asari, Caulis Piperis Kadsurae and Radix Glycyrrhizae;
Step 2: the Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Semen Cuscutae, Radix Achyranthis, the Rhizoma Anemarrhenae, Rhizoma Atractylodis, Herba Asari are pulverized respectively, the concentration adding 7-10 times of weight after mixing is the ethanol of 60-70%, soaks 6-12 hour, and backflow decocts, extract 1-3 time, each 2-4 hour, filters, and retains filtering residue, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55-60 DEG C of relative density be the concentrated solution of 1.20-1.25, for subsequent use;
Step 3: Rhizoma Coptidis, Fructus Psoraleae, Rhizoma Dioscoreae, Spina Gleditsiae, Herba Lycopodii, Fructus Liquidambaris, Caulis Piperis Kadsurae and Radix Glycyrrhizae are pulverized respectively, with the purified water adding 6-8 times of weight after the filtering residue mixing of step 2, backflow decocts 1-3 time, each 1-3 hour, filter, merging filtrate, being concentrated into 55-60 DEG C of relative density is the concentrated solution of 1.20-1.25, for subsequent use;
Step 4: merged by concentrated solution obtained in step 2 and step 3, mix homogeneously, continuing to be evaporated to 55-60 DEG C of relative density is the thick paste of 1.30-1.35, obtains Chinese medicine composition of the present invention.
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| CN201510469951.8A CN104958525A (en) | 2015-08-04 | 2015-08-04 | Traditional Chinese medicine composition for treating chronic infectious arthritis and preparation method of traditional Chinese medicine composition |
| CN201610338444.5A CN105998582A (en) | 2015-08-04 | 2015-08-04 | Preparation method of traditional Chinese medicinal composition for treating rheumatoid arthritis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596594A (en) * | 2016-03-04 | 2016-05-25 | 济南正骐生物科技有限公司 | Traditional Chinese medicine for treating rheumatoid arthritis and preparation method thereof |
| CN108379435A (en) * | 2018-04-08 | 2018-08-10 | 李树锋 | A kind of extract oral agent for treating rheumatoid arthritis |
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| CN1257715A (en) * | 1998-12-21 | 2000-06-28 | 任岩东 | Tincture for treating rheumatoid arthritis and its preparing process |
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| CN101380453A (en) * | 2008-07-21 | 2009-03-11 | 刘翠侠 | Oral powder and external plaster for treating hyperosteogeny and atrophic arthritis and production method thereof |
| CN101380367A (en) * | 2008-09-18 | 2009-03-11 | 何官平 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
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| CN101406646A (en) * | 2008-11-26 | 2009-04-15 | 路敦祥 | Chinese medicinal liquor for treating arthritis |
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- 2015-08-04 CN CN201610338444.5A patent/CN105998582A/en not_active Withdrawn
- 2015-08-04 CN CN201510469951.8A patent/CN104958525A/en not_active Withdrawn
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| CN1257715A (en) * | 1998-12-21 | 2000-06-28 | 任岩东 | Tincture for treating rheumatoid arthritis and its preparing process |
| CN1432381A (en) * | 2002-01-15 | 2003-07-30 | 卢忠 | Chinese medicine for treating various rheumarthritis |
| CN1559496A (en) * | 2004-03-08 | 2005-01-05 | 马艳峰 | Chinese medicine preparation of removing obstruction in the channels for treating atrophic arthritis |
| CN101380453A (en) * | 2008-07-21 | 2009-03-11 | 刘翠侠 | Oral powder and external plaster for treating hyperosteogeny and atrophic arthritis and production method thereof |
| CN101380367A (en) * | 2008-09-18 | 2009-03-11 | 何官平 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
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| CN105596594A (en) * | 2016-03-04 | 2016-05-25 | 济南正骐生物科技有限公司 | Traditional Chinese medicine for treating rheumatoid arthritis and preparation method thereof |
| CN108379435A (en) * | 2018-04-08 | 2018-08-10 | 李树锋 | A kind of extract oral agent for treating rheumatoid arthritis |
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| CN105998582A (en) | 2016-10-12 |
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