CN104922395A

CN104922395A - Traditional Chinese medicine composition and nursing method for treating osteoporotic thoracolumbar vertebral compression fractures

Info

Publication number: CN104922395A
Application number: CN201510329322.5A
Authority: CN
Inventors: 赵冰芝
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-07
Filing date: 2015-06-07
Publication date: 2015-09-23

Abstract

The invention discloses a traditional Chinese medicine composition for treating osteoporotic thoracolumbar vertebral compression fractures. According to the traditional Chinese medical science, osteoporosis is mainly caused by spleen and kidney deficiency and especially takes kidney deficiency as the main cause and spleen deficiency as the secondary cause. The pathogenesis of osteoporosis mainly is kidney deficiency and blood stasis. Accordingly, according to the traditional Chinese medicine composition, the traditional Chinese medicine of orobanche coerulescens, wallich swallowwort roots, shrubberry rhodiola roots, adina rubella hance, ficus lyrata, caragana franchetiana, smilax riparia, cibotium barometz, parasitic loranthus, crisped tinospora stems, gumi roots and Chinese begonia rhizome is selected and decocted with water into a decoction; through the clinical trials, the total effective rate is 97.9 percent which is obviously superior to the control group, the treatment effect is remarkable, and the composition is worthy of clinical application and popularization.

Description

A kind of Chinese medicine composition and care method for the treatment of osteoporotic thoracolumbar vertebral compression fracture

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of osteoporotic thoracolumbar vertebral compression fracture.

Background technology

Compressed fracture of thoracic vertebra and lumber vertebra is comparatively common clinically, and be one of common complication of patients with osteoporosis, be more common in postmenopausal women, case fatality rate is up to 12%-20%.Osteoporotic fracture is because bone resorption strengthens, and bone loss minimizing causes osteoporosis, destroys the fine structure of bone, thus the fragility of bone is increased, slight external force just can cause easily fracture, sickness rate and disability rate high, especially common with compressed fracture of thoracic vertebra and lumber vertebra.In recent years, along with the development of social population's aging, osteoporotic thoracolumbar vertebral compression fracture patient is in ascendant trend year by year, and the pain brought of fracturing and the inconvenient activity caused have had a strong impact on the quality of life of patient.Costly, wound is large, and long-term bed can increase the weight of sclerotin injury degree in addition for traditional operation treatment, and fracture is difficult to healing and then forms vicious cycle, has a strong impact on treatment rate; The Western medicine drug expectant treatment cycle is long, onset is slow, curative effect is not good enough.In the past few years, inventor utilizes treatment by Chinese herbs, and this is sick, receives good curative effect, Chinese medicine scalable organism endocrine function, suppresses bone resorption, reduces the conversion ratio of bone, reduces bone loss, increases bone density, effective protect against osteoporosis.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of osteoporotic thoracolumbar vertebral compression fracture.The traditional Chinese medical science is thought, bone withers primarily of caused by deficiency of spleen and stomach, and especially to suffer from a deficiency of the kidney, insufficiency of the spleen is auxiliary.The pathogenesis of primary disease is mainly " suffering from a deficiency of the kidney " " blood stasis ", should adopt the method for blood-activating bone-strengthening of tonifying Qi of the kidney.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment osteoporotic thoracolumbar vertebral compression fracture is made up of the Chinese medicine of following weight portion: Herba Orobanches 4.5-9 part, Radix cynanchi wallichii 30-60 part, Radix Rhodiolae Dumulosae 9-12 part, Fructus Adinae 9-15 part, Caulis et Folium Fici beecheyanae 30-60 part, Yunnan caragana 3-9 part, Radix et Rhizoma Smilacis Ripariae 9-15 part, Rhizoma Cibotii 4.5-9 part, Herba Taxilli 9-18 part, Caulis Tinosporae crispae 9-15 part, Radix Elaeagni Multiflorae 9-24 part, Rhizoma Begoniae Sinensis 15-30 part.

Preferably, Herba Orobanches 6 parts, Radix cynanchi wallichii 45 parts, Radix Rhodiolae Dumulosae 10.5 parts, Fructus Adinae 12 parts, Caulis et Folium Fici beecheyanae 45 parts, Yunnan caragana 6 parts, Radix et Rhizoma Smilacis Ripariae 12 parts, Rhizoma Cibotii 6 parts, Herba Taxilli 13 parts, Caulis Tinosporae crispae 12 parts, Radix Elaeagni Multiflorae 16 parts, Rhizoma Begoniae Sinensis 23 parts.

Above-mentioned Chinese medicine decocting is made decoction by preparation method.

Fang Zhong: Herba Orobanches the kidney invigorating, strong; Radix cynanchi wallichii Bu Shen Zhuang waist, bone and muscle strengthening; Radix Rhodiolae Dumulosae the kidney invigorating, invigorate blood circulation, regulating menstruation; Fructus Adinae tonify deficiency kidney tonifying, to invigorate blood circulation; Caulis et Folium Fici beecheyanae invigorating the spleen and replenishing QI, bone and muscle strengthening; Yunnan caragana QI invigorating kidney tonifying; Radix et Rhizoma Smilacis Ripariae QI invigorating, active, invigorate blood circulation; Rhizoma Cibotii invigorating the liver and kidney; Herba Taxilli invigorating the liver and kidney, beneficial blood, bone and muscle strengthening; Caulis Tinosporae crispae restores menstrual flow and invigorates blood circulation; Radix Elaeagni Multiflorae is invigorated blood circulation, circulation of qi promoting, tonifying deficiency; Rhizoma Begoniae Sinensis is invigorated blood circulation.

Clinical data

1, physical data is chosen and is carried out my institute's orthopaedics because of serious waist chest and back pain in JIUYUE, 2010 to 2013 year March and connect subject osteoporotic thoracolumbar vertebral compression fracture patient 96 example, is divided into observation group at random, each 48 examples of matched group by hospital order.Man 19 example in matched group, female 29 example; Year mean age (69.8 ± 1.8); In observation group man 18 example, female 30 example, the mean age (70.1 ± 1.6) year.Be fresh vertebral compression fracture, wherein simple thoracic vertebra compression fracture 39 example, simple lumbar vertebra compression fracture 21 example, thoracolumbar vertebral compression fracture 36 example; Single vertebral fracture 56 example, many vertebral fracture 40 examples; Totally 169 vertebral bodys, T _7,8each 8, T ₉20, T ₁₀25, T ₁₁41, T ₁₂26, L ₁12, L ₂17, L ₃8, L ₄4,2 groups of Genders, age, vertebral fracture position and fracture physical data comparing difference not statistically significant such as quantity, degree (P > 0.05), have comparability.

2, diagnostic criteria makes a definite diagnosis pathological changes vertebral body through position, positive side X-ray film, MRI; Spiral CT scan pathological changes vertebral body rear wall is complete, without obvious spinal canal stenosis; Laboratory and general physical checkup are without obvious surgical contraindication.

3, Therapeutic Method matched group: all patients are 3 days expert PVP after being admitted to hospital, concrete operation method: patient gets ventricumbent position, row local anaesthesia or epidural anesthesia, pedicle approach punctures.The entry point that punctures is determined under C arm X-ray machine perspective, with the special medullo-puncture needle of PVP through skin, pedicle of vertebral arch center slopes inwardly 10-15 °, slowly evenly thrust, pierce parallel with soleplate for puncture needle from the outer upper limb of pedicle of vertebral under normotopia perspective, when needle point reaches pedicle of vertebral 1/2 place, puncture needle is positioned at pedicle of vertebral midline, proof inserting needle is correct, continue puncture until needle point reaches 1/3 place in before vertebral body, extract puncture needle core, the sticky shape bone cement prepared in advance is sucked with special syringe, inject pathological changes vertebral body under fluoroscopy, when having larger resistance sense or bone cement to expand to vertebral body trailing edge in injection process, stop injection, there is lower limb pain and the symptom such as uncomfortable in chest if occur in vertebral body seepage or injection process, injection should be stopped immediately.Injection rate is about 3-6mL, and injection terminates rear stop 5-10 minute, and after waiting bone cement to solidify, rotate puncture needle and pull out, pin mouth gauze is wrapped up.If single injection < 50%, feasible same vertebral body offside vertebral pedicle puncture injection.In art, the vital sign of strict monitoring patient, lies in bed and can wear waistline out-of-bed activity after 24 hours.Observation group: apply Chinese medicine and treat on the basis of operative treatment.Take Herba Orobanches 6g, Radix cynanchi wallichii 45g, Radix Rhodiolae Dumulosae 10.5g, Fructus Adinae 12g, Caulis et Folium Fici beecheyanae 45g, Yunnan caragana 6g, Radix et Rhizoma Smilacis Ripariae 12g, Rhizoma Cibotii 6g, Herba Taxilli 13g, Caulis Tinosporae crispae 12g, Radix Elaeagni Multiflorae 16g, Rhizoma Begoniae Sinensis 23g, decocting divides 2 decoction being taken warmly, 1 dose/d, within 1 month, be 1 course for the treatment of, treat 3 courses for the treatment of altogether.

4, criterion of therapeutical effect pain relief degree standard: with reference to WHO pain relief degree standard.Complete incidence graph (CR): completely painless after treatment; Partial rcsponse (PR): pain obviously alleviates before comparatively treating, and does not substantially affect sleep, can orthobiosis; Minor responses (MR): pain alleviates before comparatively treating to some extent, but still obviously, sleep influenced; Invalid (NR): before and after treatment, pain degree is unchanged.

5, therapeutic outcome observation group patient 48 example, complete incidence graph 25 example (52.1%), partial rcsponse 20 example (41.7%), minor responses 2 example (4.1%), invalid 1 example (2.1%), total effective rate is 97.9%; Matched group patient 48 example, complete incidence graph 12 example (25%), partial rcsponse 18 example (37.5%), minor responses 11 example (22.9%), invalid 7 examples (14.6%).Total effective rate is 85.4%.Two groups of contrasts, significant difference.

Detailed description of the invention

Embodiment one: take Herba Orobanches 6g, Radix cynanchi wallichii 45g, Radix Rhodiolae Dumulosae 10.5g, Fructus Adinae 12g, Caulis et Folium Fici beecheyanae 45g, Yunnan caragana 6g, Radix et Rhizoma Smilacis Ripariae 12g, Rhizoma Cibotii 6g, Herba Taxilli 13g, Caulis Tinosporae crispae 12g, Radix Elaeagni Multiflorae 16g, Rhizoma Begoniae Sinensis 23g, above-mentioned Chinese medicine decocting is made decoction.

Embodiment two: Herba Orobanches 9g, Radix cynanchi wallichii 60g, Radix Rhodiolae Dumulosae 12g, Fructus Adinae 15g, Caulis et Folium Fici beecheyanae 60g, Yunnan caragana 9g, Radix et Rhizoma Smilacis Ripariae 15g, Rhizoma Cibotii 9g, Herba Taxilli 18g, Caulis Tinosporae crispae 15g, Radix Elaeagni Multiflorae 24g, Rhizoma Begoniae Sinensis 30g, makes decoction by above-mentioned Chinese medicine decocting.

Embodiment three: Herba Orobanches 4.5g, Radix cynanchi wallichii 30g, Radix Rhodiolae Dumulosae 9g, Fructus Adinae 9g, Caulis et Folium Fici beecheyanae 30g, Yunnan caragana 3g, Radix et Rhizoma Smilacis Ripariae 9g, Rhizoma Cibotii 4.5g, Herba Taxilli 9g, Caulis Tinosporae crispae 9g, Radix Elaeagni Multiflorae 9g, Rhizoma Begoniae Sinensis 15g, makes decoction by above-mentioned Chinese medicine decocting.

Claims

1. treat a Chinese medicine composition for osteoporotic thoracolumbar vertebral compression fracture, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba Orobanches 4.5-9 part, Radix cynanchi wallichii 30-60 part, Radix Rhodiolae Dumulosae 9-12 part, Fructus Adinae 9-15 part, Caulis et Folium Fici beecheyanae 30-60 part, Yunnan caragana 3-9 part, Radix et Rhizoma Smilacis Ripariae 9-15 part, Rhizoma Cibotii 4.5-9 part, Herba Taxilli 9-18 part, Caulis Tinosporae crispae 9-15 part, Radix Elaeagni Multiflorae 9-24 part, Rhizoma Begoniae Sinensis 15-30 part.

2. a kind of Chinese medicine composition for the treatment of osteoporotic thoracolumbar vertebral compression fracture as claimed in claim 1, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: preferential, Herba Orobanches 6 parts, Radix cynanchi wallichii 45 parts, Radix Rhodiolae Dumulosae 10.5 parts, Fructus Adinae 12 parts, Caulis et Folium Fici beecheyanae 45 parts, Yunnan caragana 6 parts, Radix et Rhizoma Smilacis Ripariae 12 parts, Rhizoma Cibotii 6 parts, Herba Taxilli 13 parts, Caulis Tinosporae crispae 12 parts, Radix Elaeagni Multiflorae 16 parts, Rhizoma Begoniae Sinensis 23 parts.