CN104905405B - The cigarette of the essence containing plant flavone mouth stick preparation method and application - Google Patents

Abstract

The invention discloses a preparation method and application of a tobacco mouth stick containing plant flavonoid essence. kaempferol, 10% to 30% naringin, after mixing, the ethanol solution is used as the extraction solvent for reflux extraction, and the extract is filtered to obtain the extract; 2) the extract is evenly sprayed in the tow; 3) then the extract in step 2) drying the tow; 4) wrapping the dried tow with molding paper and tipping paper in turn to prepare a cigarette tip containing plant flavonoid essence. The cigarette mouthpiece containing plant flavonoid essence brings comfortable smelling feeling to the cigarette. When the cigarette is smoked, these substances are burned and cracked to produce aroma components that can increase the amount and quality of aroma; and the tobacco with plant flavonoid essence The active ingredient in the mouth stick enters the oral cavity of the human body along with the smoke in the cigarette, and can directly act on the larynx to improve the comfort of the larynx.

Description

Preparation method and application of cigarette mouthpiece containing plant flavonoid essence

technical field

The invention belongs to the technical field of cigarettes, and in particular relates to a preparation method and application of a cigarette mouthpiece containing plant flavonoid essence.

Background technique

Natural plants are widely used in tobacco flavors, many of which contain flavonoids. According to the molecular structure characteristics of flavonoids and the strength of the interaction between electrons, preliminary studies have found that such substances will produce furan substances and their derivatives after combustion and cracking. These substances are the main aroma components in smoke. It will bring caramel, sweet and roasted aroma to the smoke, and increase the amount and quality of aroma. Therefore, in the deployment of flavors and fragrances for tobacco, there are many flavonoid flavor raw materials used.

Many studies have also shown that flavonoids have a variety of biological activities. In addition to their antibacterial, anti-inflammatory, anti-mutation, blood pressure, heat-clearing and detoxifying, sedative, diuretic and other effects, flavonoids have anti-oxidation, anti-cancer, anti-cancer, and inhibition of lipase. There are also significant effects in other aspects. It is a scavenger for most oxygen free radicals, so it can increase the activity of SOD (superoxide dismutase), reduce the activity of MDA (lipid peroxide malondialdehyde) and OX-LDL (oxidized low-density lipoprotein) generate. It can increase coronary flow, has antagonizing effect on experimental myocardial infarction; has protective effect on acute myocardial ischemia; has significant effect on treating coronary heart disease, angina pectoris, hypertension, etc.; reduces diastolic blood pressure, prevents arrhythmia, cardiovascular Disease and promoting blood circulation and removing blood stasis also play an important role.

A large number of scientific studies have proved from different perspectives that tobacco smoke is an important risk factor for the occurrence of chronic respiratory diseases, coronary heart disease and other diseases. Long-term smokers generally have symptoms of cough, phlegm, and sore throat, which seriously affect human health and quality of life. In addition, passive smoking is also harmful to women's health. In order to reduce the harm of smoke in tobacco to the human body, while actively promoting that smoking is harmful to health and persuading smoking cessation, it is also necessary to actively develop harm-reducing cigarettes with functions such as soothing the throat.

The larynx is an important part of the respiratory tract, located at the junction of the trachea and esophagus, and is also an important organ for human pronunciation. When a smoker is smoking, the throat is most susceptible to the harmful substances in the smoke. The tar in the smoke is easily trapped in the smoker's body, condenses into a viscous substance in the lungs, and adheres to the surface of the smoker's trachea, bronchi and alveoli, causing physical and chemical stimulation and affecting the breathing of the human body; smoking for a long time will reduce the The defense function of the mucous membrane of the throat will cause dry cough, throat tingling and other sensations, or the throat will be uncomfortable due to excessive anger caused by smoking; so smoking is more harmful to the human respiratory tract, especially the throat. May cause laryngeal lesions for a long time.

A large number of related studies have found that the respiratory tract, as the organ directly exposed to external gas stimulation, is the main recipient of tobacco damage. Respiratory epithelial cells, as the first line of defense against external stimuli, suffer particularly serious damage. Previous studies have shown that cigarette stimulation can regulate alveolar epithelium and bronchial epithelium urokinase type plasminogen activator (uPA), urokinase type plasminogen activator receptor (urokinase type plasminogen activator receptor, uPAR) The expression of the system changed, and the levels of uPA and uPAR in the alveolar epithelial cells were more significantly up-regulated, showing the dominant state of uPA, which was conducive to proteolysis. The bronchial epithelial cells present a dominant state of urokinase-type plasminogen activator inhibitor-1 (plasminogen activator inhibitor-1, PAI-1), which is conducive to the formation of fibrosis. The different expression status of the uPA system in the two cells may partly explain the cause of the two different pathological changes of emphysema and small airway fibrosis in COPD patients. Another literature has reported that co-incubation of rat lung tissue slices with cigarette smoke extracts can increase the leakage of lactate dehydrogenase (lactatec dehydrogenate, LDH) and the release of nitrite NO2- in rat lung tissue, and stimulate inducible nitric oxide synthase. (induced nitric oxide synthase, iNOS) activity increases, leading to lung damage. It can be seen that long-term smoke exposure can cause damage to the morphology and function of respiratory epithelial cells, thereby affecting the normal physiological functions of the upper and lower respiratory tracts, causing smokers to feel uncomfortable, and even seriously affecting the quality of life (QOF) and life. Safety. Starting from safeguarding the interests of consumers, taking the road of reducing tar and harm is the development direction of Chinese cigarettes. On the premise of meeting the physiological and psychological needs of consumers, reducing its adverse effects on the throat of consumers and improving the comfort of the throat are problems that researchers in the tobacco industry need to solve urgently.

Good throat comfort refers to the smooth and delicate smoke experienced by consumers when smoking cigarettes, no residue in the mouth, no irritation to the nose and throat, and a sweet aftertaste. Laryngeal reaction is mainly concentrated in the mouth and respiratory system during cigarette smoking, which is reflected in the improvement of puncture reduction, phlegm reduction, body fluid production, etc., and can better experience the comfort of smoking.

Prick reduction: Irritation refers to the impact of smoke on the senses. In terms of feelings, it is divided into three types: oral stimulation, nasal cavity stimulation and throat stimulation. The highly irritating ones seem to have a "spicy" taste in the mouth, cause tears or a sense of tears in the nasal cavity, and constrict the throat and cause coughing in the throat.

The irritation of smoke is mainly caused by excessive acidity and alkalinity in cigarettes, and is also related to the moisture and tightness of cigarettes. Spicy thorns are due to too much alkaline substances; choking thorns are due to too many small molecule particles; sharp thorns (burrs) are due to too much acidic substances.

Flavonoids have the effect of relaxing bronchial smooth muscle. When added to cigarettes, they can weaken the shrinking effect of smoke and relieve the discomfort caused by the impact of smoke on the throat.

Resolving phlegm: Long-term smokers generally have a certain degree of pharyngitis, which is manifested by excessive and frequent phlegm. Harmful substances in the smoke frequently accumulate in the respiratory tract, which accelerates the peristalsis of fluff fibers.

Flavonoids can reduce phlegm-producing substances in smoke, which is bound to reduce the accumulation of such components in the respiratory system. In addition, flavonoids can accelerate the peristalsis of tracheal villi fibers, so that harmful substances can be quickly excreted from the body with secretions, which to a certain extent has the effect of reducing phlegm.

Shengjin: Jin is saliva, and Shengjin means to secrete saliva from the mouth. Modern medicine also believes that saliva contains a variety of ingredients that are beneficial to the body, and the production of body fluid in the mouth can quench thirst and comfort.

A variety of flavonoids have the effects of nourishing yin and promoting body fluid, moistening lungs and clearing fire, and quenching thirst due to internal heat. Added in cigarettes, it can stimulate the taste buds in the mouth and have the effect of promoting body fluids. The smoke is more mellow, accompanied by a sense of sweetness, and reduces the sense of dryness.

Many tobacco flavors contain flavonoids, but there are no reports on flavor formulas that are specifically aimed at improving throat comfort, cough, phlegm, and asthma, and further research is needed.

Contents of the invention

Aiming at the deficiencies of the prior art, the present invention provides a preparation method and application of a cigarette mouthpiece containing plant flavonoid essence, which has the effects of relieving cough, reducing phlegm, and relieving asthma. The plant flavonoid essence is added to the tow of the mouthpiece, and the During the smoking process of cigarettes, it exerts its excellent anti-inflammation and throat sharpening effects, thereby improving the throat comfort of cigarette smoking and improving the quality of cigarette smoking.

The technical solution adopted by the present invention to solve the above-mentioned technical problems is to provide a method for preparing a cigarette mouthpiece containing plant flavonoid essence, comprising the following steps:

1) Weigh 20% to 60% of luteolin, 20% to 60% of baicalin, 10% to 30% of kaempferol and 10% to 30% of naringin by weight percentage, and mix the ethanol solution as The extraction solvent is refluxed for extraction, and filtered to obtain the extract;

2) Spray the extract evenly in the tow;

3) then the tow in step 2) is dried;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

Further, the mass percent concentration of the ethanol solution is 70%-90%.

Further, in the step 1), the reflux extraction is carried out 2 to 4 times, and each reflux extraction takes 2 to 4 hours.

Further, the drying temperature in the step 3) is 25°C-40°C.

A cigarette, comprising a mouthpiece for tobacco and shredded tobacco, the mouthpiece for tobacco is the mouthpiece for tobacco containing plant flavonoid essence prepared by the method described above.

The present invention has the following advantages:

1. The cigarette mouthpiece containing plant flavonoid essence of the present invention has an excellent natural smell, which brings a comfortable smelling feeling to the cigarette. When the cigarette is smoked, these substances are burned and cracked to produce a fragrance that can increase the amount of aroma and the quality of the aroma. Fragrance components further improve the smoking quality of cigarettes;

2. The active ingredients in the cigarette mouthpiece containing plant flavonoid essence of the present invention enter the oral cavity of the human body along with the smoke in the cigarette, and can directly act on the throat, playing a good role in improving the comfort of the throat;

3. The plant flavonoid flavor raw materials of the present invention come from a wide range of sources, are low in cost, and are convenient for popularization and application.

Detailed ways

In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. The specific embodiments described here are only used to explain the present invention, not to limit the present invention.

Example 1

1) Mix the plant flavonoid essence according to the ratio in Table 1, dissolve it in an ethanol solution with a mass percentage concentration of 70%, reflux and extract twice, extract for 3 hours each time, filter and mix to obtain an extract;

2) evenly spraying the extract in step 1) in the tow;

3) then drying the tow in step 2) at 25°C;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

Table 1

Types of flavonoids Luteolin Baicalin Kaempferol Naringin weight percentage 30% 20% 30% 20%

Example 2

1) Mix the plant flavonoid essence according to the ratio in Table 1, dissolve it in an ethanol solution with a mass percentage concentration of 70%, reflux and extract twice, extract for 4 hours each time, filter and mix to obtain the extract;

2) evenly spraying the extract in step 1) in the tow;

3) then drying the tow in step 2) at 35°C;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

Table 2

Types of flavonoids Luteolin Baicalin Kaempferol Naringin weight percentage 30% 30% 20% 20%

Example 3

1) Mix the plant flavonoid essence according to the ratio in Table 1, dissolve it in an ethanol solution with a mass percentage concentration of 80%, reflux extraction 4 times, extract for 2 hours each time, filter and mix to obtain the extract;

2) evenly spraying the extract in step 1) in the tow;

3) then drying the tow in step 2) at 35°C;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

table 3

Types of flavonoids Luteolin Baicalin Kaempferol Naringin weight percentage 40% 30% 15% 15%

Example 4

1) Mix the plant flavonoid essence according to the ratio in Table 1, dissolve it in an ethanol solution with a mass percentage concentration of 80%, reflux and extract twice, extract for 4 hours each time, filter and mix to obtain the extract;

2) evenly spraying the extract in step 1) in the tow;

3) then drying the tow in step 2) at 35°C;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

Table 4

Types of flavonoids Luteolin Baicalin Kaempferol Naringin weight percentage 40% 40% 10% 10%

Example 5

1) Mix the plant flavonoid essence according to the ratio in Table 1, dissolve it in an ethanol solution with a mass percentage concentration of 90%, reflux and extract twice, extract for 2 hours each time, filter and mix to obtain an extract;

2) evenly spraying the extract in step 1) in the tow;

3) then drying the tow in step 2) at 40°C;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

table 5

Types of flavonoids Luteolin Baicalin Kaempferol Naringin weight percentage 20% 20% 30% 30%

Example 6

1) Mix the plant flavonoid essence according to the ratio in Table 1, dissolve it in an ethanol solution with a mass percentage concentration of 90%, reflux extraction 4 times, extract for 2 hours each time, filter and mix to obtain an extract;

2) evenly spraying the extract in step 1) in the tow;

3) then drying the tow in step 2) at 40°C;

4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence.

Table 6

Types of flavonoids Luteolin Baicalin Kaempferol Naringin weight percentage 25% 25% 25% 25%

Aiming at the three major symptoms of "cough, phlegm, and wheezing" caused by smoking, on the basis of referring to the classic pharmacodynamic evaluation methods of respiratory antitussive, expectorant, and antiasthmatic, a variety of different biological models were screened to establish applicable Based on the method of evaluating the respiratory protection effect of natural plant extracts, the antitussive effect was evaluated by the ammonia water induction method in mice, the expectorant effect was evaluated by the phenol red excretion method in mice, and the antiasthmatic effect was evaluated by the guinea pig isolated trachea spiral strip method.

The cigarette mouthpieces containing plant flavonoid essence prepared in the above 6 examples are joined with shredded tobacco to make cigarettes, and the smoke components of the cigarettes are tested, and the phenol reduction rate is compared, as shown in the following table 7

Table 7

*P<0.05, **P<0.01 compared with blank cigarette group with the same count

The mouth sticks for cigarettes containing plant flavonoid essence prepared in the examples of the above 6 examples are joined with shredded tobacco to make cigarettes, and the cigarettes are subjected to sensory evaluation, and the results are shown in Table 8

Table 8

The above is only a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto, any changes or substitutions that can be easily imagined by those skilled in the art within the technical scope disclosed in the present invention, All should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.

Claims (4)

1. a method for preparing a cigarette mouthpiece containing plant flavonoid essence, characterized in that: the preparation method comprises the steps: 1) Weigh 20% to 40% of luteolin, 20% to 40% of baicalin, 10% to 30% of kaempferol and 10% to 30% of naringin by weight percentage, and mix the ethanol solution as The extraction solvent is refluxed for extraction, and the extract is obtained by filtration; the mass percent concentration of the ethanol solution is 70% to 90%; 2) Spray the extract evenly in the tow; 3) then the tow in step 2) is dried; 4) Wrapping the dried tow with molding paper and tipping paper successively to prepare a cigarette tip containing plant flavonoid essence. 2 . The method for preparing tobacco mouthpieces containing plant flavonoid essence according to claim 1 , characterized in that: in the step 1), reflux extraction is carried out 2 to 4 times, and each reflux extraction takes 2 to 4 hours. 3. The method for preparing tobacco mouthpiece containing plant flavonoid essence according to claim 1, characterized in that: the drying temperature in the step 3) is 25°C-40°C. 4. A cigarette, comprising a tobacco mouthpiece and shredded tobacco, characterized in that: the tobacco mouthpiece is the tobacco mouthpiece containing plant flavonoid essence prepared by the method according to any one of claims 1-3.