CN104857107B - A kind of fat reducing preparation method of composition and fitness reducing agent - Google Patents
A kind of fat reducing preparation method of composition and fitness reducing agent Download PDFInfo
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- CN104857107B CN104857107B CN201510282957.4A CN201510282957A CN104857107B CN 104857107 B CN104857107 B CN 104857107B CN 201510282957 A CN201510282957 A CN 201510282957A CN 104857107 B CN104857107 B CN 104857107B
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Abstract
The invention provides a kind of preparation method of fat reducing composition, comprise the following steps：The first component and the second component are configured, wherein the percentage that each material for forming the first component accounts for first, second component weight is：Safflower 8 10%；Myrrh 15 30%；Levisticum 4 6%；Selfheal 3 5%；Hawthorn 3 5%；Frankincense 5 8%；Big fruit gamboge 5 7%；Semen brassicae 2 3%；Marine alga 3 4%；Peppermint 2 5%；Each material for forming the second component accounts for the percentage of first, second component weight and is：Azone 1 2%；Borneol 0.2 3%；1.3 butanediols 4 6%；Glycerine 1 3%；Carbomer 0.1 0.5%；Sodium hydroxide 0.1 0.5%；Ethanol 2 5%；Phenoxyethanol 0.2 0.8%；Surplus is deionized water；Then the first component is well mixed after decocting, concentrate, separate, sterilize with the second component.Gained fat reducing composition of the invention has significant fat-reducing effect.
Description
Technical field
The present invention relates to a kind of composition with fat reducing function, more particularly to the preparation method of said composition.
Background technology
Simple obesity refers to the mainly obesity as caused by inherent cause and overnutrition, and simple obesity is all kinds of obesities
In most common one kind, account for 95% of obese people or so, the distribution of people's body fat with simple obesity than more uniform,
There is no endocrine disturbance phenomenon, often have fat medical history without dysbolism disease, its family yet.
At present, simple obesity is the highly developed national social concern of modern economy.In some national obesity
The incidence of disease is up to 20~30%.China is because social stability, people's living standard improve, and dietary structure and custom are inadequate in addition
Rationally, the simple obesity incidence of disease is also in rising trend.According to China in recent years, neonate accounts for 70%, and children 4~9.5%,
Puberty 21%, manhood 18~32%, senescence phase all suffer from obesity up to 28%, but existing diet products its effects is often
It is not obvious enough.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of fat reducing composition with notable fat-reducing effect and provided
A kind of fitness reducing agent prepared using the fat reducing composition.
In order to solve the above technical problems, the present invention adopts the following technical scheme that：
A kind of preparation method of fat reducing composition, comprises the following steps：
1) the first component and the second component are configured, wherein each material for forming the first component accounts for first, second component gross weight
The percentage of amount is：Safflower 8-10%；Myrrh 15-30%；Levisticum 4-6%；Selfheal 3-5%；Hawthorn 3-5%；Frankincense 5-
8%；Big fruit gamboge 5-7%；Semen brassicae 2-3%；Marine alga 3-4%；Peppermint 2-5%；Each material for forming the second component accounts for first,
The percentage of second component weight is：Azone 1-2%；Borneol 0.2-3%；1.3 butanediol 4-6%；Glycerine 1-3%；Card ripple
Nurse 0.1-0.5%；Sodium hydroxide 0.1-0.5%；Ethanol 1-5%；Phenoxyethanol 0.2-0.8%；Surplus is deionized water；
2) the first component is added water to cook, takes its decoction, it is standby after concentrated, separation, sterilizing；
3) the second component is well mixed, and the first component is added into the second component and stirred obtained fat reducing composition.
In inventive formulation：
Safflower, Classification system：Carthamustinctorius L., alias：Red blue flower, thorn safflower, composite family, safflower category are planted
Thing, there is the effect of promoting blood circulation and removing blood stasis, dissipate wet effect going to swell.
Myrrh, also known as myrrh, cure mainly chest and abdomen stasis caused pain, dysmenorrhoea, Amenorrhea, abdominal mass, traumatic injury, carbuncle swells sore, acute appendicitis, hot eyes
Swelling and pain, there is promoting blood circulation and stopping pain, detumescence and promoting granulation and other effects.
Levisticum, alias houseleek, solely slide, archangel, there is dispelling wind and eliminating dampness, arthritis analgesic efficacy.
Selfheal, scientific name：Prunella vulgaris L, alias：Wheat head selfheal, red eye, swell pain, headache etc. can be controlled,
Clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.
Hawthorn, (Crataeguspinnatifida Bunge), also known as hawthorn, rose family May, have it is aid digestion,
The effect of reducing blood lipid, antiatherosclerosis.
Frankincense, Boswellia, there is the effect of blood-activating and qi-promoting analgesic, detumescence and promoting granulation.It is usually used in treating chest impediment and cardialgia, pain of gastric cavity
Bitterly, dysmenorrhoea Amenorrhea, postpartum stasis, abdominal mass stomachache, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore etc..
Big fruit gamboge (Garciniapedunculata Roxb.), also known as weight reducing fruit, fat-reducing fruit, have weight reducing, invigorating the spleen disappears
Food, relax bowel, the effect such as reducing pharyngeal swelling, extra-nutrition, cancer-resisting.
Semen brassicae, alias hot food, Latin literary fame Semen sinapis. have warm lung slit phlegm profit gas, and dissipating bind is removed obstruction in channels to relieve pain
Effect.
Marine alga nature and flavor are salty-cold, have the effect of heat-clearing, softening and resolving hard mass.
Peppermint, it is pungent cool property sweating antipyretic medicine, is usually used in treating influenza, headache, hot eyes, body heat, throat, gum
The diseases such as swelling and pain.
Azone, molecular formula C18H35NO, can be used as bleeding agent,
Borneol, also known as orange slices, it is to be laid equal stress on by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves through steam distillation
Crystallize and obtain.Card coma, red eye, swell pain are closed available for treatment, and larynx numbness aphtha, for sore swell and ache curative is not held back after bursting.
Carbomer, English name Carbomer, it is the macromolecule that acrylic acid is bonded allyl sucrose or pentaerythrite allyl ether
Polymer.
The main pharmacological of this formula is to adjust body fat and the activity of metabolic enzyme, promotes body fat to decompose, makes
Body is issued to the purpose of fat-reducing in normal physiological condition.
Preferably, the mass ratio of the component of step 2) first and water is 1:4-6, decoct 1 to 3 time, merge the medicine decocted every time
Liquid.
Preferably, the first component is decocted 3 times, wherein the water decocted for the first time is 6 times of the first component, second and third
The water of secondary decoction is 4 times.More specifically, bubble 4-6 hours are invaded before decocting for the first time, boiling is decocted and continues 30 minutes.
Preferably, the first component of the invention crosses 60 mesh sieves.
Preferably, step 2) is concentrated using film decoction being concentrated into 0.5-0.9g/ml.Specifically, before being concentrated to decoction
The ethanol with decoction identical weight is added into decoction, through filtering to take its decoction after sedimentation.
For step 2) of the present invention using centrifuging, rotating speed is 3000 revs/min, and centrifugation time is 30 minutes.
Step 2) sterilising temp of the present invention is 105 DEG C, and sterilization time is 30 minutes.
Present invention also offers a kind of fitness reducing agent with fat reducing effect, by above-mentioned gained fat reducing composition and Transparent soap base
Composition, wherein fat reducing composition and the mass ratio of Transparent soap base are 20:80.
The present invention takes full advantage of the advantageous natural resources of Chinese medicinal materials in China, and safflower is filtered out from over one hundred kind of Chinese herbal medicine, is not had
The multi-flavor traditional Chinese medicine of medicine, levisticum, hawthorn etc. ten, the extraction process by strict scientific composition and uniqueness extract fat reducing combination
Thing.Soaps due to the active ingredient and as carrier, it is entirely natural materials, transdermal stimulation is tested, to human body skin
Any irritative response is not produced.
Confirmed by modern medical research methods, the main pharmacological of this formula is adjustment body fat and metabolic enzyme
Activity, promote body fat to decompose, body is issued to the purpose of fat-reducing in normal physiological condition, this anti-obesity mechanism ratio uses
Anorectic effect Alcohol class medicine, lead let out class medicine, hormone medicine fat-reducing is more beneficial for health, realize fat-reducing and do not force and go on a diet, no
Subtract muscle power, do not cause the beneficial effect of metabolic disorder.
Embodiment
Below by embodiment to the further specific descriptions of the present invention.The present invention design philosophy or allied substances it is simple
Replacement belongs to protection scope of the present invention.If experimental method is that the art is existing without specified otherwise used in following
Conventional method, used dispensing or material, are by the available dispensing of commercial sources or material unless otherwise specified
Material.
Embodiment 1
Fitness reducing agent of the present invention is prepared by following steps：
1) the first component and the second component are configured, wherein each material for forming the first component accounts for first, second component gross weight
The percentage of amount is：Safflower 7%；Myrrh 20%；Levisticum 6%；Selfheal 5%；Hawthorn 4%；Frankincense 5%；Big fruit gamboge 7%；
Semen brassicae 3%；Marine alga 4%；Peppermint 5%；
Each material for forming the second component accounts for the percentage of first, second component weight and is：Azone 2%；Borneol
0.2%；1.3 butanediols 4%；Glycerine 3%；Carbomer 0.1% (production of Hubei Kang Baotai fine chemistry industries company)；Sodium hydroxide
0.1%；Ethanol 2%；Phenoxyethanol 0.2%；Surplus is deionized water；
2) the first component is proceeded as follows：
Pretreatment
The Chinese medicine of first component is prepared in proportion, 60 mesh sieves is crossed, removes soil；
Decoct
The Chinese medicine of first component is put into storage tank, soaked 4-6 hours, the matter of the first component drug quality and water
Amount is than being 1:6, then decoct at ambient pressure to boiling, and boiling 30 minutes is kept, last vertical centrifugal goes out what is decocted for the first time
Decoction.
After taking out decoction, then add into medicine the water of 4 times of the first component drug quality and carry out second and decoct, be centrifuged out
Second of decoction, equally, then add into medicine the water of 4 times of the first component drug quality and carry out third time decoction, be centrifuged out the
Decoction three times, the decoction decocted three times by more than merge.
Concentration and alcohol precipitation
By above-mentioned medicine, according to traditional liquid film concentration, (one kind that film concentration refers to be carried out with thin film evaporator depressurizes dense
Contracting mode, prior art, the present invention are not described in detail) mode is concentrated into 0.5-0.6g crude drugs/ml, and normal pressure is dense after taking-up
It is reduced to 0.9g crude drugs/ml；Cooling sedimentation, decoction room temperature is placed 1 hour, until equilibrium at room temperature；Add and decoction 1：1 second
Alcohol, settled 1 hour after stirring evenly, filtering precipitate to clear liquid, film is concentrated into 0.9g crude drugs/ml；
Separation
Decoction after concentration is centrifuged, centrifugal rotational speed is 3000 revs/min, and centrifugation time is 30 minutes；Pour out supernatant
Liquid, load in sterilizing bottle and sterilize, sterilising temp is 105 DEG C, and sterilization time is 30 minutes.
3) the second component is fully dissolved, be well mixed, and the first component is added the second component and stirs to be made and is subtracted
Oil/fat composition.
4) by fat reducing composition obtained by step 3) pour into Transparent soap base (Ba Sha daily chemical products Co., Ltd of Shenzhen produces,
Model 1008) in, stir, pour into fat-reducing perfumed soap, the mass ratio of fat reducing composition and Transparent soap base is 20:80.
The application method of fat-reducing perfumed soap obtained by the present embodiment：When taking a shower body is wiped as using general perfumed soap i.e.
Can.
Through toxotest, by oral 4 months of three dosage groups of rat point, to its body weight, food-intake, liver function, renal function,
Blood, the discovery without exception of routine urinalysis and each tissue pathology checking.
Salmonella reversion test and CHL cell tests system results show that mutagenicity is not presented.
Test 1 fat-reducing effect
This experiment carries out survey for simple obesity patient, in the patient using the gained fitness reducing agent of embodiment 1
In, the user for selecting 100 16 years old the present embodiment fat-reducing soap surroundings used above at random is investigated, statistical result such as table 1
Shown, fat-reducing effect is divided into Three Estate by this experiment, is effective, effective and minor effect respectively, as it can be seen from table 1 this implementation
Example fitness reducing agent is respectively provided with remarkable result on the fat-reducing effect of body weight, abdominal circumference and hip circumference, it is particularly possible to is obviously reduced abdominal circumference size.
The subject's fat-reducing effect statistical form of table 1
Experiment 2
This experiment carries out survey for simple obesity patient, in the patient using the gained fitness reducing agent of embodiment 1
In, 20 are selected at random and is investigated using the user of surrounding within 8~14 years old, and statistical result is as shown in table 2 to table 4, as a result table
Bright, the present embodiment fitness reducing agent equally has significant fat-reducing effect to teenager.
Test result of the table 2 to teenager's body weight
Test result of the table 3 to teenager's abdominal circumference
Test result of the table 4 to teenager's hip circumference
Embodiment 2
Fitness reducing agent of the present invention is prepared by following steps：
1) the first component and the second component are configured, wherein each material for forming the first component accounts for first, second component gross weight
The percentage of amount is：Safflower 10%；Myrrh 30%；Levisticum 6%；Selfheal 5%；Hawthorn 5%；Frankincense 5%；Big fruit gamboge 5%；
Semen brassicae 2%；Marine alga 3%；Peppermint 3%；
Each material for forming the second component accounts for the percentage of first, second component weight and is：Azone 1%；Borneol 3%；
1.3 butanediols 6%；Glycerine 1%；Carbomer 0.5%；Sodium hydroxide 0.5%；Ethanol 5%；Phenoxyethanol 0.8%；Surplus is to go
Ionized water；
2) the first component is proceeded as follows：
Pretreatment
The Chinese medicine of first component is prepared in proportion, 60 mesh sieves is crossed, removes soil；
Decoct
The Chinese medicine of first component is put into storage tank, soaked 4-6 hours, the matter of the first component drug quality and water
Amount is than being 1:6, then decoct at ambient pressure to boiling, and boiling 30 minutes is kept, last vertical centrifugal goes out what is decocted for the first time
Decoction.
After taking out decoction, then add into medicine the water of 4 times of the first component drug quality and carry out second and decoct, be centrifuged out
Second of decoction, equally, then add into medicine the water of 4 times of the first component drug quality and carry out third time decoction, be centrifuged out the
Decoction three times, the decoction decocted three times by more than merge.
Concentration
Above-mentioned decoction film is concentrated into 0.5-0.6g crude drugs/ml, normal pressure is concentrated into 0.9g crude drugs/ml after taking-up；Cooling
Sedimentation, decoction room temperature is placed 1 hour, until equilibrium at room temperature；Add and decoction 1：1 ethanol, settled 1 hour after stirring evenly, mistake
Sediment is filtered to clear liquid, film is concentrated into 0.9g crude drugs/ml；
Separation
Decoction after concentration is centrifuged, centrifugal rotational speed is 3000 revs/min, and centrifugation time is 30 minutes；Pour out supernatant
Liquid, load in sterilizing bottle and sterilize, sterilising temp is 105 DEG C, and sterilization time is 30 minutes.
3) the second component is well mixed, and the first component is added into the second component and stirred obtained fitness reducing agent.
The present embodiment anoretic is actually a kind of fat-reducing cream, can Direct Uniform be applied on skin and use.
Through toxotest, by oral 4 months of three dosage groups of rat point, to its body weight, food-intake, liver function, renal function,
Blood, the discovery without exception of routine urinalysis and each tissue pathology checking.
Salmonella reversion test and CHL cell tests system results show that mutagenicity is not presented.
Experiment 3
This experiment carries out survey for simple obesity patient, in the patient using the gained fitness reducing agent of embodiment 1
In, the user for selecting 100 16 years old surroundings used above at random is investigated, and statistical result is as shown in table 5, and this experiment will subtract
Fertilizer efficiency fruit is divided into Three Estate, is effective, effective and minor effect respectively.As can be seen from Table 5, the present embodiment fitness reducing agent body weight,
Remarkable result is respectively provided with abdominal circumference and the fat-reducing effect of hip circumference, it is particularly possible to is obviously reduced abdominal circumference size.
The subject's fat-reducing effect statistical form of table 5
Experiment 4
This experiment carries out survey for simple obesity patient, in the patient using the gained fitness reducing agent of embodiment 1
In, 20 are selected at random and is investigated using the user of surrounding within 8~14 years old, and statistical result is as shown in table 6 to table 8, as a result table
Bright, the present embodiment fitness reducing agent equally has significant fat-reducing effect to teenager.
Test result of the table 6 to teenager's body weight
Test result of the table 7 to teenager's abdominal circumference
Test result of the table 8 to teenager's hip circumference
Embodiment 3
Fitness reducing agent of the present invention is prepared by following steps：
1) the first component and the second component are configured, wherein each material for forming the first component accounts for first, second component gross weight
The percentage of amount is：Safflower 8%；Myrrh 15%；Levisticum 4%；Selfheal 3%；Hawthorn 3%；Frankincense 8%；Big fruit gamboge 5%；
Semen brassicae 2%；Marine alga 3%；Peppermint 2%；
Each material for forming the second component accounts for the percentage of first, second component weight and is：Azone 1%；Borneol 3%；
1.3 butanediols 6%；Glycerine 1%；Carbomer 0.5%；Sodium hydroxide 0.5%；Ethanol 5%；Phenoxyethanol 0.8%；Surplus is to go
Ionized water；
2) the first component is proceeded as follows：
Pretreatment
The Chinese medicine of first component is prepared in proportion, 60 mesh sieves is crossed, removes soil；
Decoct
The Chinese medicine of first component is put into storage tank, soaked 4-6 hours, the matter of the first component drug quality and water
Amount is than being 1:6, then decoct at ambient pressure to boiling, and boiling 30 minutes is kept, last vertical centrifugal goes out what is decocted for the first time
Decoction.
After taking out decoction, then add into medicine the water of 4 times of the first component drug quality and carry out second and decoct, be centrifuged out
Second of decoction, equally, then add into medicine the water of 4 times of the first component drug quality and carry out third time decoction, be centrifuged out the
Decoction three times, the decoction decocted three times by more than merge.
Concentration
Above-mentioned decoction film is concentrated into 0.5-0.6g crude drugs/ml, normal pressure is concentrated into 0.9g crude drugs/ml after taking-up；Cooling
Sedimentation, decoction room temperature is placed 1 hour, until equilibrium at room temperature；Add and decoction 1：1 ethanol, settled 1 hour after stirring evenly, mistake
Sediment is filtered to clear liquid, film is concentrated into 0.9g crude drugs/ml；
Separation
Decoction after concentration is centrifuged, centrifugal rotational speed is 3000 revs/min, and centrifugation time is 30 minutes；Pour out supernatant
Liquid, load in sterilizing bottle and sterilize, sterilising temp is 105 DEG C, and sterilization time is 30 minutes.
3) the second component is well mixed, and the first component is added into the second component and stirred obtained fitness reducing agent.
4) fat reducing composition obtained by step 3) is poured into Transparent soap base, stirs, pour into fat-reducing perfumed soap, fat reducing group
Compound and the mass ratio of Transparent soap base are 5:95.
Through toxotest, by oral 4 months of three dosage groups of rat point, to its body weight, food-intake, liver function, renal function,
Blood, the discovery without exception of routine urinalysis and each tissue pathology checking.
Salmonella reversion test and CHL cell tests system results show that mutagenicity is not presented.
Experiment 5
This experiment carries out survey for simple obesity patient, in the patient using the gained fitness reducing agent of embodiment 1
In, the user for selecting 100 16 years old surroundings used above at random is investigated, and statistical result is as shown in table 9, and this experiment will subtract
Fertilizer efficiency fruit is divided into Three Estate, is effective, effective and minor effect respectively.As can be seen from Table 9, the present embodiment fitness reducing agent body weight,
Remarkable result is respectively provided with abdominal circumference and the fat-reducing effect of hip circumference, it is particularly possible to is obviously reduced abdominal circumference size.
The subject's fat-reducing effect statistical form of table 9
Experiment 6
This experiment carries out survey for simple obesity patient, in the patient using the gained fitness reducing agent of embodiment 1
In, 20 are selected at random and is investigated using the user of surrounding within 8~14 years old, and statistical result is as shown in table 10 to table 12, as a result
Show, the present embodiment fitness reducing agent equally has significant fat-reducing effect to teenager.
Test result of the table 10 to teenager's body weight
Test result of the table 11 to teenager's abdominal circumference
Test result of the table 12 to teenager's hip circumference
Claims (10)
1. a kind of preparation method of fat reducing composition, comprises the following steps：
1）The first component and the second component are configured, wherein each material for forming the first component accounts for first, second component weight
Percentage is：Safflower 8-10%；Myrrh 15-30%；Levisticum 4-6%；Selfheal 3-5%；Hawthorn 3-5%；Frankincense 5-8%；Big fruit gamboge
5-7%；Semen brassicae 2-3%；Marine alga 3-4%；Peppermint 2-5%；Each material for forming the second component accounts for first, second component weight
Percentage is：Azone 1-2%；Borneol 0.2-3%；1.3 butanediol 4-6%；Glycerine 1-3%；Carbomer 0.1-0.5%；Sodium hydroxide
0.1-0.5%；Ethanol 2-5%；Phenoxyethanol 0.2-0.8%；Surplus is deionized water；
2）First component is added water to cook, takes its decoction, it is standby after concentrated, separation, sterilizing；
3）Second component is well mixed, and the first component is added into the second component and stirred obtained fat reducing composition.
2. fat reducing preparation method of composition according to claim 1, it is characterised in that step 2）The matter of first component and water
Amount is than being 1:4-6, decoct 1 to 3 time, merge the decoction decocted every time.
3. fat reducing preparation method of composition according to claim 2, it is characterised in that the first component is decocted 3 times, wherein
The water decocted for the first time is 6 times of the first component, and the water of second and third decoction is 4 times.
4. fat reducing preparation method of composition according to claim 3, it is characterised in that immersion 4-6 is small before decocting for the first time
When, decoct boiling and continue 30 minutes.
5. fat reducing preparation method of composition according to claim 4, it is characterised in that the first component crosses 60 mesh sieves.
6. fat reducing preparation method of composition according to any one of claims 1 to 5, it is characterised in that step 2）Using film
Decoction is concentrated into 0.5-0.9g/ml by concentration.
7. fat reducing preparation method of composition according to claim 6, it is characterised in that add before being concentrated to decoction into decoction
Enter the ethanol with decoction identical weight, through filtering to take its decoction after sedimentation.
8. fat reducing preparation method of composition according to claim 7, it is characterised in that step 2）Using centrifugation, turn
Speed is 3000 revs/min, and centrifugation time is 30 minutes.
9. fat reducing preparation method of composition according to claim 6, it is characterised in that step 2）Sterilising temp is 105 DEG C,
Sterilization time is 30 minutes.
10. a kind of fitness reducing agent, be made up of claim 1 to 9 gained fat reducing composition and Transparent soap base, wherein fat reducing composition with
The mass ratio of Transparent soap base is 5~20:80~95.
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