CN104803665A - Anti-aging aluminum oxide ceramic and preparation method thereof - Google Patents
Anti-aging aluminum oxide ceramic and preparation method thereof Download PDFInfo
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- CN104803665A CN104803665A CN201510145003.9A CN201510145003A CN104803665A CN 104803665 A CN104803665 A CN 104803665A CN 201510145003 A CN201510145003 A CN 201510145003A CN 104803665 A CN104803665 A CN 104803665A
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- oxide
- ageing
- hydroxyapatite
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- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000003712 anti-aging effect Effects 0.000 title abstract 2
- 239000011224 oxide ceramic Substances 0.000 title abstract 2
- 229910052574 oxide ceramic Inorganic materials 0.000 title abstract 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 40
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims abstract description 26
- -1 polybutylene succinate Polymers 0.000 claims abstract description 26
- 230000032683 aging Effects 0.000 claims abstract description 24
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 20
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 20
- 229920002961 polybutylene succinate Polymers 0.000 claims abstract description 20
- 239000004631 polybutylene succinate Substances 0.000 claims abstract description 20
- 239000011787 zinc oxide Substances 0.000 claims abstract description 20
- 229910000480 nickel oxide Inorganic materials 0.000 claims abstract description 14
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 14
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 11
- 238000006243 chemical reaction Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 20
- 229960004643 cupric oxide Drugs 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 11
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 229960001866 silicon dioxide Drugs 0.000 claims description 9
- 229940024548 aluminum oxide Drugs 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 229910052733 gallium Inorganic materials 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 229960001296 zinc oxide Drugs 0.000 claims description 6
- 229910052786 argon Inorganic materials 0.000 claims description 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000919 ceramic Substances 0.000 abstract description 7
- 238000005245 sintering Methods 0.000 abstract description 4
- 238000002425 crystallisation Methods 0.000 abstract description 2
- 230000008025 crystallization Effects 0.000 abstract description 2
- 239000005751 Copper oxide Substances 0.000 abstract 2
- 229910000431 copper oxide Inorganic materials 0.000 abstract 2
- 239000011521 glass Substances 0.000 abstract 2
- 239000011261 inert gas Substances 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 description 4
- 239000012620 biological material Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000011173 biocomposite Substances 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- NKCVNYJQLIWBHK-UHFFFAOYSA-N carbonodiperoxoic acid Chemical compound OOC(=O)OO NKCVNYJQLIWBHK-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000012890 simulated body fluid Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
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- Materials For Medical Uses (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
The invention discloses anti-aging aluminum oxide ceramic and a preparation method thereof. The ceramic comprises raw materials in parts by weight as follows: 80-140 parts of aluminum oxide, 10-20 parts of zinc oxide, 1-6 parts of silicon dioxide, 10-20 parts of copper oxide, 10-40 parts of nickel oxide, 10-20 parts of hydroxyapatite and 10-20 parts of polybutylene succinate. The preparation method comprises the following steps: aluminum oxide, zinc oxide, silicon dioxide, copper oxide, nickel oxide, hydroxyapatite and polybutylene succinate are added to a reaction still, an inert gas is introduced, and the mixture reacts for 3-4 h at the temperature of 1,000-1,500 DEG C and is cooled naturally. The inert gas is adopted to serve as a sintering atmosphere, a glass phase can be placed in a crystallization position, and the glass phase is prevented from degradation and ageing in a body.
Description
Technical field
The present invention relates to biological technical field, particularly relate to a kind of ageing-resistant alumina-ceramic and preparation method thereof.
Background technology
Biomaterial, comprises bio-vitric, biological ceramics, Biocomposite material, biological coating etc., is that a class can repair through row skin tissue, substitute and regeneration, has the material of specific function.Because it has higher biological activity, biocompatibility and chemical stability, research is in recent years very active.At present, increasing biological ceramics is used to the displacement of tissue.Bone Defect Repari perplexed by materialogy always, relates generally to the soundness of material and the consistency of its biology.Biological ceramics is the biomaterial of a class excellent property, and it has good biological activity and biocompatibility.By the circulation of body fluid, at biological ceramics, there is close ion-exchange between soft tissue and bone, this ion-exchange has caused mineralization, final formation hydroxycarbonate apatite layer, it is the same with the mineral substance form of normal bone tissues, can induce Bone Defect Repari and regeneration.Biomaterial various aspects of performance is all good, but easily agingly becomes fragile, and causes detrimentally affect.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of ageing-resistant alumina-ceramic and preparation method thereof, ageing-resistant performance is good, and proterties can be kept steady in a long-term.
The present invention is by the following technical solutions:
Ageing-resistant alumina-ceramic, comprises the raw material of following parts by weight: 80 ~ 140 parts, aluminum oxide, 10 ~ 20 parts, zinc oxide, silica 1 ~ 6 part, cupric oxide 10 ~ 20 parts, nickel oxide 10 ~ 40 parts, hydroxyapatite 10 ~ 20 parts, polybutylene succinate 10 ~ 20 parts.
As preferably, the particle diameter of zinc oxide is 100-300nm.
As preferably, in hydroxyapatite, the ratio of Ga and P is 1:1.67.
As preferably, the relative molecular mass of polybutylene succinate is 10000 ~ 60000.
The preparation method of above-mentioned ageing-resistant alumina-ceramic, comprise the following steps: aluminum oxide, zinc oxide, silicon-dioxide, cupric oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, be filled with rare gas element, at 1000 ~ 1500 DEG C of reaction 3 ~ 4h, naturally cooling.
As preferably, rare gas element is nitrogen or argon gas.
The present invention adopts rare gas element as sintering atmosphere, can prevent glassy phase from appearing at crystallization place, avoids glassy phase that degraded occurs in vivo aging.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described in detail.
embodiment 1
Ageing-resistant alumina-ceramic, comprises the raw material of following parts by weight: 80 parts, aluminum oxide, 10 parts, zinc oxide, silica 1 part, cupric oxide 10 parts, nickel oxide 10 parts, hydroxyapatite 10 parts, polybutylene succinate 10 parts.
The particle diameter of zinc oxide is 100nm.
In hydroxyapatite, the ratio of Ga and P is 1:1.67.
The relative molecular mass of polybutylene succinate is 10000.
The preparation method of above-mentioned ageing-resistant alumina-ceramic, comprise the following steps: aluminum oxide, zinc oxide, silicon-dioxide, cupric oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, is filled with nitrogen, at 1000 DEG C of reaction 3h, naturally cooling.
embodiment 2
Ageing-resistant alumina-ceramic, comprises the raw material of following parts by weight: 140 parts, aluminum oxide, 20 parts, zinc oxide, silicon-dioxide 6 parts, cupric oxide 20 parts, nickel oxide 40 parts, hydroxyapatite 20 parts, polybutylene succinate 20 parts.
The particle diameter of zinc oxide is 300nm.
In hydroxyapatite, the ratio of Ga and P is 1:1.67.
The relative molecular mass of polybutylene succinate is 60000.
The preparation method of above-mentioned ageing-resistant alumina-ceramic, comprise the following steps: aluminum oxide, zinc oxide, silicon-dioxide, cupric oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, is filled with nitrogen or argon gas, at 1500 DEG C of reaction 4h, naturally cooling.
embodiment 3
Ageing-resistant alumina-ceramic, comprises the raw material of following parts by weight: 100 parts, aluminum oxide, 15 parts, zinc oxide, silicon-dioxide 4 parts, cupric oxide 15 parts, nickel oxide 30 parts, hydroxyapatite 15 parts, polybutylene succinate 15 parts.
The particle diameter of zinc oxide is 200nm.
In hydroxyapatite, the ratio of Ga and P is 1:1.67.
The relative molecular mass of polybutylene succinate is 40000.
The preparation method of above-mentioned ageing-resistant alumina-ceramic, comprise the following steps: aluminum oxide, zinc oxide, silicon-dioxide, cupric oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, is filled with nitrogen or argon gas, at 1200 DEG C of reaction 3.5h, naturally cooling.
embodiment 4
Ageing-resistant alumina-ceramic, comprises the raw material of following parts by weight: 130 parts, aluminum oxide, 12 parts, zinc oxide, silicon-dioxide 2 parts, cupric oxide 12 parts, nickel oxide 20 parts, hydroxyapatite 12 parts, polybutylene succinate 18 parts.
The particle diameter of zinc oxide is 230nm.
In hydroxyapatite, the ratio of Ga and P is 1:1.67.
The relative molecular mass of polybutylene succinate is 40000.
The preparation method of above-mentioned ageing-resistant alumina-ceramic, comprise the following steps: aluminum oxide, zinc oxide, silicon-dioxide, cupric oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, is filled with nitrogen or argon gas, at 1200 DEG C of reaction 3.4h, naturally cooling.
comparative example 1
Identical with embodiment 1, difference is: be not filled with rare gas element and sinter, and utilizes air as sintering atmosphere.
performance test
The pottery of the alumina-ceramic of comparative example 1 and embodiment 1 ~ 4 is placed on after soaking 30 days in simulated body fluid, observes ceramic surface.The Surface Edge embrittlement of comparative example 1 is yellow, and the ceramic surface of embodiment 1 ~ 4 is all unchanged.
Illustrate that the present invention has good ageing-resistant performance, this is because low oxygen pressure can reduce in sintering process produce glassy phase, prevent degraded aging.
Be only wherein several specific embodiments of the application above, but the application is not limited thereto, the changes that any person skilled in the art can think of, all should drops in the protection domain of the application.
Claims (6)
1. ageing-resistant alumina-ceramic, it is characterized in that, comprise the raw material of following parts by weight: 80 ~ 140 parts, aluminum oxide, 10 ~ 20 parts, zinc oxide, silica 1 ~ 6 part, cupric oxide 10 ~ 20 parts, nickel oxide 10 ~ 40 parts, hydroxyapatite 10 ~ 20 parts, polybutylene succinate 10 ~ 20 parts.
2. ageing-resistant alumina-ceramic according to claim 1, is characterized in that, the particle diameter of zinc oxide is 100-300nm.
3. ageing-resistant alumina-ceramic according to claim 1, is characterized in that, in hydroxyapatite, the ratio of Ga and P is 1:1.67.
4. ageing-resistant alumina-ceramic according to claim 1, is characterized in that, the relative molecular mass of polybutylene succinate is 10000 ~ 60000.
5. based on the preparation method of ageing-resistant alumina-ceramic according to claim 1, it is characterized in that, comprise the following steps: aluminum oxide, zinc oxide, silicon-dioxide, cupric oxide, nickel oxide, hydroxyapatite, polybutylene succinate are added in reactor, be filled with rare gas element, at 1000 ~ 1500 DEG C of reaction 3 ~ 4h, naturally cooling.
6. the preparation method of ageing-resistant alumina-ceramic according to claim 5, is characterized in that, rare gas element is nitrogen or argon gas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510145003.9A CN104803665B (en) | 2015-03-31 | 2015-03-31 | Anti-aging aluminum oxide ceramic and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510145003.9A CN104803665B (en) | 2015-03-31 | 2015-03-31 | Anti-aging aluminum oxide ceramic and preparation method thereof |
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| Publication Number | Publication Date |
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| CN104803665A true CN104803665A (en) | 2015-07-29 |
| CN104803665B CN104803665B (en) | 2017-02-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106316370A (en) * | 2016-08-18 | 2017-01-11 | 景德镇瓷玉研究所 | Novel jade ceramic material and preparation method and application of novel jade ceramic |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106316370A (en) * | 2016-08-18 | 2017-01-11 | 景德镇瓷玉研究所 | Novel jade ceramic material and preparation method and application of novel jade ceramic |
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| CN104803665B (en) | 2017-02-08 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Qiu Caijun Inventor before: Pan Lingen Inventor before: Liu Daxue Inventor before: Guo Yuqin |
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Effective date of registration: 20160905 Address after: 312400, Zhejiang Province, Shaoxing City, Shengzhou Province town, Keng Keng Village, Jin Heng 68 Applicant after: Shengzhou Bona Hardware Machinery Plant Address before: Wuzhong District town Suzhou city Jiangsu province 215101 gold Jinchang Road No. 360 Applicant before: Suzhou Vivotide Biotechnologies Co., Ltd. |
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Effective date of registration: 20181108 Address after: 313009 286, Shuikou Town, Shuikou village, Nanxun Town, Huzhou City, Zhejiang Patentee after: Zhejiang Hanguang Environmental Protection Technology Co., Ltd. Address before: 312400 Zhejiang, Shaoxing, Shengzhou, Gan Lin Town, small Hang Village, Jin Heng No. 68 Patentee before: Shengzhou Bona Hardware Machinery Plant |
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Effective date of registration: 20190418 Address after: 362599 Pengxiang Industrial Zone, Longxun Town, Dehua County, Quanzhou City, Fujian Province Patentee after: Fujian Dehua Chengyi Ceramics Co.,Ltd. Address before: 313009 286, Shuikou Town, Shuikou village, Nanxun Town, Huzhou City, Zhejiang Patentee before: Zhejiang Hanguang Environmental Protection Technology Co., Ltd. |