CN104784539A - 一种用于治疗慢性牙周炎的中药 - Google Patents
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Abstract
本发明涉及一种用于治疗慢性牙周炎的中药，它是由以下重量配比的原料药材制备而成：忍冬藤15份、升麻15份、鱼腥草12份、黄连15份、牡丹皮12份、芦根10份、生地10份、当归6份。临床实验证明，本发明能够安全有效治疗慢性牙周炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种用于治疗慢性牙周炎的中药。
背景技术
慢性牙周炎是常见口腔疾病之一，其不仅可引起口腔异味、牙龈出血等症状影响患者生活、工作，且易迁延不愈，反复发作进而导致牙槽骨吸收，牙齿脱落。现代医学对其多以抗菌素联合牙周基础治疗，疗效佳但抗菌素长期应用不良反应较多，易产生耐药性，疗效逐渐降低。慢性牙周炎多因厌氧菌、牙龈类杆菌、产黑色素杆菌等致病菌因牙石、食物嵌塞、牙菌斑等原因长期滞留、附着，细菌大量繁殖，出现局部牙龈炎症反应，缓慢进展，反复发作，菌斑从龈上向龈下进展，破坏牙周胶原、上皮细胞，导致牙龈附着丧失，形成牙周袋，破坏牙槽骨，严重影响患者生活、工作，最终造成牙齿脱落，影响发音、咀嚼功能。消除致病菌滞留环境，抑制局部炎性反应，是有效抑制慢性牙周炎进展的关键。牙周基础治疗是消除致病菌滞留环境的最主要措施，其通过局部刮治清除牙周袋内异常增生组织，对牙槽骨进行适当修整，以利于牙周再附着，减轻牙周损伤，逐步消除牙周袋，但其疼痛较为剧烈，需在良好镇痛下进行，避免加重患者心理负担。
本发明所涉及药材研究现状如下：
忍冬藤【别名】忍冬、银花藤、金银藤。【来源】本品为忍冬科植物忍冬的干燥茎枝。秋、冬二季采割，晒干。【性味】甘，寒。【归经】归肺、胃经。【功能主治】清热解毒，疏风通络。用于温病发热，热毒血痢，痈肿疮疡，风湿热痹，关节红肿热痛。【用法用量】内服：煎汤，9～30g。【注意】脾胃虚寒，泄泻不止者禁用。【摘录】《中华本草》。
升麻【别名】龙眼根、窟窿牙根。【来源】中药升麻为毛茛科多年生草本植物三叶升麻或兴安升麻或升麻的根茎。【性味】辛、甘，微寒。【归经】归肺、脾、大肠、胃经。【功能主治】发表透疹、清热解毒，升举阳气。用于风热头痛，麻疹不畅，齿痛口疮，咽喉肿痛，脏器下垂。【用法用量】内服：煎汤，3～10g。【注意】阳虚阳浮，喘满气逆及麻疹已透者忌用。升举阳气宜用炙升麻。【摘录】《中华本草》。
鱼腥草【别名】侧耳根、猪鼻孔、臭草、鱼鳞草。【来源】本品为三白草科植物蕺菜的干燥地上部分。夏季茎叶茂盛花穗多时采割，除去杂质，晒干。【性味】辛，微寒。【归经】归肺经。【功能主治】清热解毒，消痈排脓，利尿通淋。用于肺痈吐脓，痰热喘咳，热痢，热淋，痈肿疮毒。【用法用量】内服：煎汤，15～25g，不宜久煎。【注意】虚寒症及阴性外疡忌服。【摘录】《中华本草》。
黄连【别名】川连、姜连、川黄连。【来源】多年生草本植物，喜冷凉、湿润之处，属毛莨科黄连属。【性味】(根)苦，寒，无毒。【归经】归心、脾、胃、肝、胆、大肠经。【功能主治】清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。酒黄连善清上焦火热。用于目赤，口疮。姜黄连清胃和胃止呕。用于寒热互结，湿热中阻，痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和，呕吐吞酸。【用法用量】内服：煎汤，2～5g。【注意】本品大苦大寒，过服久服易伤脾胃，脾胃虚寒者忌用。苦燥伤津，阴虚津伤者慎用。【摘录】《中华本草》。
牡丹皮【别名】丹皮、粉丹皮、木芍药、条丹皮、洛阳花。【来源】本品为毛茛科植物牡丹的干燥根皮。秋季采挖根部，除去细根，剥取根皮，晒干。【性味】苦、辛，微寒。【归经】归心、肝、肾经。【功能主治】清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。【用法用量】内服：煎汤，6-12g。【注意】血虚有寒，孕妇及月经过多者慎服。【摘录】《中华本草》。
芦根【别名】苇根、芦头。【来源】本品为禾本科植物芦苇的新鲜或干燥根茎。全年均可采挖，除去芽、须根及膜状叶，鲜用或晒干。【性味】甘，寒。【归经】归肺、胃经。【功能主治】清热生津，除烦，止呕，利尿。用于热病烦渴，胃热呕哕，肺热咳嗽，肺痈吐脓，热淋涩痛。【用法用量】内服：煎汤，15～30g。【注意】因寒霍乱阼胀，因寒呕吐勿服。【摘录】《中华本草》。
生地【别名】地黄、地髓、阳精、苄根，牛奶子根、狗奶子根、婆婆奶根、山烟根，山旱烟生地药材根，山烟根，山白菜根、酒壶花根、酒盅盅花根、甜酒棵根、蜜罐棵根、生地、大生地、小生地、干生地、怀生地、地黄根。【来源】为玄参科植物地黄的干燥块根。【性味】味甘、苦，性微寒。【归经】归心、肝、肾经。质润降泄。【功能主治】清热凉血，用于温热病热入营血，壮热神昏，口干舌绛。治温病后期，余热未尽，阴液已伤，夜热早凉，舌红脉数者。可用于治温热病热入营血，血热毒盛，吐血衄血，斑疹紫黑。养阴生津功效用于津伤口渴，内热消渴。治温病伤阴，肠燥便秘。【用法用量】内服：煎汤，10～30g。【注意】性寒而滞，脾虚湿滞腹满便溏者，不宜使用。【摘录】《中华本草》。
当归【别名】干归。【来源】本品为伞形科植物当归的干燥根。秋末采挖，除去须根及泥沙，待水分稍蒸发后，捆成小把，上棚，用烟火慢慢熏干。【性味】甘、辛，温。【归经】归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。【用法用量】内服：煎汤，10～25g。【注意】湿阻中满及大便溏泄者慎服。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗慢性牙周炎的中药，通过选择合适的药材及其配比，达到安全有效治愈慢性牙周炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗慢性牙周炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：忍冬藤15份、升麻15份、鱼腥草12份、黄连15份、牡丹皮12份、芦根10份、生地10份、当归6份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院慢性牙周炎患者130例，随机分为治疗组65例与对照组65例，治疗组男39例，女26例，年龄43～67岁，平均年龄53岁；对照组男41例，女24例，年龄42～68岁，平均年龄60岁，病程1～9年。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国慢性牙周炎临床专业会议的诊断标准：(1)有口腔异味、牙龈疼痛、出血等症状；(2)牙周检查可发现牙龈炎性水肿、溢脓，龈乳头退缩，牙齿松动、移位；(3)探诊发现附着丧失，深度＞3mill；(4)x线片有牙槽骨吸收影像学改变；(5)口气热臭，舌红苔黄，喜冷恶热，口干舌燥，脉滑数，辨证属胃热炽盛。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程一个月。
对照组口服替硝唑片0.5g/次，2次/天，疗程一个月。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：口腔异味、牙龈疼痛、出血、红肿、溢脓等临床症状均消失，牙齿松动度改善I度以上，牙龈萎缩未进展；
有效：牙龈疼痛消失，出血、红肿、溢脓等症状明显减轻，牙齿松动度有所改善，牙龈萎缩未进展；
无效：未满足上述条件。
3.2治疗结果见表1。
表1两组疗效比较
可见，本发明制得的药物能够安全有效治疗慢性牙周炎，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：忍冬藤15克、升麻15克、鱼腥草12克、黄连15克、牡丹皮12克、芦根10克、生地10克、当归6克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗慢性牙周炎。口服，每日分早午晚三次服用。
实施例2
称取：忍冬藤15克、升麻15克、鱼腥草12克、黄连15克、牡丹皮12克、芦根10克、生地10克、当归6克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗慢性牙周炎。口服，每日分早午晚三次服用。
实施例3
称取：忍冬藤15克、升麻15克、鱼腥草12克、黄连15克、牡丹皮12克、芦根10克、生地10克、当归6克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗慢性牙周炎。口服，每日分早午晚三次服用。
Claims (4)
1.一种用于治疗慢性牙周炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：忍冬藤15份、升麻15份、鱼腥草12份、黄连15份、牡丹皮12份、芦根10份、生地10份、当归6份。
2.如权利要求1所述的一种用于慢性牙周炎的中药，其特征在于，其制备方法为：称取：忍冬藤15份、升麻15份、鱼腥草12份、黄连15份、牡丹皮12份、芦根10份、生地10份、当归6份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
3.如权利要求1所述的一种用于治疗慢性牙周炎的中药，其特征在于，其制备方法为：称取：忍冬藤15份、升麻15份、鱼腥草12份、黄连15份、牡丹皮12份、芦根10份、生地10份、当归6份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
4.如权利要求1所述的一种用于治疗慢性牙周炎的中药，其特征在于，其制备方法为：称取：忍冬藤15份、升麻15份、鱼腥草12份、黄连15份、牡丹皮12份、芦根10份、生地10份、当归6份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654056A (zh) * | 2004-02-10 | 2005-08-17 | 湖北丽益医药科技有限公司 | 一种治疗牙周炎的中药组合物及其制备方法 |
| CN102423428A (zh) * | 2011-12-13 | 2012-04-25 | 赵丹 | 一种治疗牙周炎的中药组合物 |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654056A (zh) * | 2004-02-10 | 2005-08-17 | 湖北丽益医药科技有限公司 | 一种治疗牙周炎的中药组合物及其制备方法 |
| CN102423428A (zh) * | 2011-12-13 | 2012-04-25 | 赵丹 | 一种治疗牙周炎的中药组合物 |
Non-Patent Citations (3)
| Title |
|---|
| 李元聪: "清胃散加味治疗急性牙源性感染204例报告", 《中国中医急症》 * |
| 温映萍等: "自拟清胃汤加减治疗成人牙周炎临床观察", 《中医药学刊》 * |
| 罗芳国: "辨证分型治疗牙周病268例疗效观察", 《湖南中医杂志》 * |
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